Alexander Kleschevnikov

Title(s)Assistant Adjunct Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Preventing cognitive impairment in mouse genetic models of Down syndrome by early postnatal suppression of Kir3.2 channel signaling
    NIH R01HD100607Sep 1, 2020 - Aug 31, 2023
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:434-450. Wang S, Leem JS, Podvin S, Hook V, Kleschevnikov N, Savchenko P, Dhanani M, Zhou K, Kelly IC, Zhang T, Miyanohara A, Nguyen P, Kleschevnikov A, Wagner SL, Trojanowski JQ, Roth DM, Patel HH, Patel PM, Head BP. PMID: 33981778.
      View in: PubMed   Mentions:
    2. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2021 02; 17(2):271-292. Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. PMID: 32975365.
      View in: PubMed   Mentions: 6     Fields:    
    3. Down syndrome. Handb Clin Neurol. 2019; 167:321-336. Rafii MS, Kleschevnikov AM, Sawa M, Mobley WC. PMID: 31753140.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    4. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2018 09 01; 28(9):3255-3266. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. PMID: 28981594.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. Graphene biointerfaces for optical stimulation of cells. Sci Adv. 2018 05; 4(5):eaat0351. Savchenko A, Cherkas V, Liu C, Braun GB, Kleschevnikov A, Miller YI, Molokanova E. PMID: 29795786.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    6. Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome. Neurobiol Dis. 2018 07; 115:1-8. Lysenko LV, Kim J, Madamba F, Tyrtyshnaia AA, Ruparelia A, Kleschevnikov AM. PMID: 29550538.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2017 Jul; 103:1-10. Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zeng Z, Yu YE, Mobley WC. PMID: 28342823.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Acute neuroinflammation provokes intracellular acidification in mouse hippocampus. J Neuroinflammation. 2016 11 03; 13(1):283. Tyrtyshnaia AA, Lysenko LV, Madamba F, Manzhulo IV, Khotimchenko MY, Kleschevnikov AM. PMID: 27809864.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    9. GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. 2016 12; 26(12):1641-1654. Mojabi FS, Fahimi A, Moghadam S, Moghadam S, Windy McNerneny M, Ponnusamy R, Kleschevnikov A, Mobley WC, Salehi A. PMID: 27701794.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. An Anti-ß-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One. 2016; 11(3):e0152471. Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC. PMID: 27023444.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    11. Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015 Nov 15; 24(22):6540-51. Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Kleschevnikov AM, Pao A, Peresie J, Wie S, Mobley WC, Yu YE. PMID: 26374847.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    12. Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. PLoS One. 2015; 10(7):e0134861. Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC. PMID: 26230397.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    13. Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. PLoS One. 2014; 9(12):e114521. Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RA, Kleschevnikov AM. PMID: 25474204.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    14. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014 Mar 03; 11:39. Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, Cui W, Voong A, Krajewski S, Ali SS, Roth DM, Patel HH, Patel PM, Head BP. PMID: 24593993.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    15. Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol Genet. 2014 Feb 01; 23(3):578-89. Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE. PMID: 24041763.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci. 2012 Jul 04; 32(27):9217-27. Kleschevnikov AM, Belichenko PV, Faizi M, Jacobs LF, Htun K, Shamloo M, Mobley WC. PMID: 22764230.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    17. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs. 2012 Jan 01; 3(1):8-12. Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE. PMID: 22126738.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Discoveries in Down syndrome: moving basic science to clinical care. Prog Brain Res. 2012; 197:199-221. Kleschevnikov AM, Belichenko PV, Salehi A, Wu C. PMID: 22541294.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    19. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2012 Feb; 45(2):683-91. Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC. PMID: 22062771.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    20. Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci. 2011; 33(5):404-13. Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE. PMID: 21865664.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    21. Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome. J Comp Neurol. 2011 May 01; 519(7):1338-54. Popov VI, Kleschevnikov AM, Klimenko OA, Stewart MG, Belichenko PV. PMID: 21452200.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    22. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of ß1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis. 2011 Aug; 43(2):397-413. Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M. PMID: 21527343.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    23. Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res. 2010 Dec 17; 1366:162-71. Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE. PMID: 20932954.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    24. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med. 2009 Nov 18; 1(7):7ra17. Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC. PMID: 20368182.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    25. The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci. 2009 May 06; 29(18):5938-48. Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC. PMID: 19420260.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    26. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol. 2009 Feb 01; 512(4):453-66. Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC. PMID: 19034952.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    27. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol. 2007 Oct 01; 504(4):329-45. Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC. PMID: 17663443.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    28. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. PMID: 16815330.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimalsCells
    29. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol. 2004 Dec 13; 480(3):281-98. Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC. PMID: 15515178.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    30. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci. 2004 Sep 15; 24(37):8153-60. Kleschevnikov AM, Belichenko PV, Villar AJ, Epstein CJ, Malenka RC, Mobley WC. PMID: 15371516.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    31. Long-term potentiation recruits a trisynaptic excitatory associative network within the mouse dentate gyrus. Eur J Neurosci. 2003 Jun; 17(12):2690-702. Kleschevnikov AM, Routtenberg A. PMID: 12823476.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. PKC activation rescues LTP from NMDA receptor blockade. Hippocampus. 2001; 11(2):168-75. Kleschevnikov AM, Routtenberg A. PMID: 11345123.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Afferent high strength tetanizations favour potentiation of the NMDA vs. AMPA receptor-mediated component of field EPSP in CA1 hippocampal slices of rats. Brain Res. 2000 Jun 02; 866(1-2):188-96. Bayazitov I, Kleschevnikov A. PMID: 10825494.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. Changes in paired-pulse facilitation correlate with induction of long-term potentiation in area CA1 of rat hippocampal slices. Neuroscience. 1997 Feb; 76(3):829-43. Kleschevnikov AM, Sokolov MV, Kuhnt U, Dawe GS, Stephenson JD, Voronin LL. PMID: 9135055.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    35. Atropine suppresses associative LTP in the CA1 region of rat hippocampal slices. Brain Res. 1995 Feb 20; 672(1-2):281-4. Sokolov MV, Kleschevnikov AM. PMID: 7749748.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    36. Neurophysiological analysis of long-term potentiation in mammalian brain. Behav Brain Res. 1995 Jan 23; 66(1-2):45-52. Voronin L, Byzov A, Kleschevnikov A, Kozhemyakin M, Kuhnt U, Volgushev M. PMID: 7755898.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    37. Fimbria-fornix lesions impair spatial performance and induce epileptic-like activity but do not affect long-term potentiation in the CA1 region of rat hippocampal slices. Brain Res. 1994 Sep 12; 656(2):221-8. Kleschevnikov AM, Sinden JD, Marchbanks R. PMID: 7820582.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    38. The M1 antagonist pirenzepine suppresses heterosynaptic STD in the CA1 region. Neuroreport. 1994 Aug 15; 5(13):1670-2. Kozhemyakin MB, Kleschevnikov AM. PMID: 7819544.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    39. Heterosynaptic short-term depression of population spike amplitude in the pyramidal layer of the CA1 hippocampal region evoked by a theta-like tetanization. Brain Res. 1993 May 21; 611(2):295-9. Kleschevnikov AM, Marchbanks RM. PMID: 8334523.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    40. Behavioral parameters of the spatial memory correlate with the potentiation of the population spike, but not with the population excitatory postsynaptic potential, of the CA1 region in rat hippocampal slices. Neurosci Lett. 1993 Apr 02; 152(1-2):125-8. Kleschevnikov AM, Marchbanks RM. PMID: 7685862.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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