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Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. Alzheimers Res Ther. 2021 03 10; 13(1):59.
Chen XQ, Das U, Park G, Mobley WC. PMID: 33691783.
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Animals
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Cholesterol-lowering drugs reduce APP processing to Aß by inducing APP dimerization. Mol Biol Cell. 2021 02 01; 32(3):247-259.
Langness VF, van der Kant R, Das U, Wang L, Chaves RDS, Goldstein LSB. PMID: 33296223.
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PubMed Mentions:
3 Fields:
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HumansCells
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The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention? Prog Mol Biol Transl Sci. 2021; 177:109-122.
Goldstein LSB, Das U. PMID: 33453937.
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Functional cooperation of a-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11113-11115.
Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. PMID: 31110017.
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PubMed Mentions:
31 Fields:
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HumansCells
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CRISPR/Cas9 editing of APP C-terminus attenuates ß-cleavage and promotes a-cleavage. Nat Commun. 2019 01 03; 10(1):53.
Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. PMID: 30604771.
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PubMed Mentions:
21 Fields:
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HumansAnimalsCells
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Amyloid-ß Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory. J Neurosci. 2017 07 19; 37(29):6926-6937.
Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. PMID: 28626017.
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PubMed Mentions:
7 Fields:
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Animals
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Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 07 03; 216(7):2059-2074.
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR, Roy S. PMID: 28559423.
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PubMed Mentions:
8 Fields:
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HumansAnimalsCells
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Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64.
Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089.
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PubMed Mentions:
69 Fields:
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AnimalsCells
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a-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol. 2014 Oct 06; 24(19):2319-26.
Wang L, Das U, Scott DA, Tang Y, McLean PJ, Roy S. PMID: 25264250.
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PubMed Mentions:
98 Fields:
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HumansAnimalsCells
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Fast vesicle transport is required for the slow axonal transport of synapsin. J Neurosci. 2013 Sep 25; 33(39):15362-75.
Tang Y, Scott D, Das U, Gitler D, Ganguly A, Roy S. PMID: 24068803.
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PubMed Mentions:
18 Fields:
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AnimalsCells
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Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60.
Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. PMID: 23931995.
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PubMed Mentions:
88 Fields:
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AnimalsCells
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The slow axonal transport of alpha-synuclein--mechanistic commonalities amongst diverse cytosolic cargoes. Cytoskeleton (Hoboken). 2012 Jul; 69(7):506-13.
Tang Y, Das U, Scott DA, Roy S. PMID: 22344896.
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PubMed Mentions:
13 Fields:
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AnimalsCells
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Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid ß-protein oligomers. Traffic. 2012 May; 13(5):681-93.
Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S. PMID: 22309053.
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PubMed Mentions:
31 Fields:
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AnimalsCells
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Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron. 2011 May 12; 70(3):441-54.
Scott DA, Das U, Tang Y, Roy S. PMID: 21555071.
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PubMed Mentions:
48 Fields:
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AnimalsCells
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Domain organization and function in GluK2 subtype kainate receptors. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8463-8.
Das U, Kumar J, Mayer ML, Plested AJ. PMID: 20404149.
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PubMed Mentions:
24 Fields:
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HumansAnimalsCells
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Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key. PLoS One. 2007 Nov 14; 2(11):e1176.
Das U, Hariprasad G, Ethayathulla AS, Manral P, Das TK, Pasha S, Mann A, Ganguli M, Verma AK, Bhat R, Chandrayan SK, Ahmed S, Sharma S, Kaur P, Singh TP, Srinivasan A. PMID: 18000547.
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PubMed Mentions:
41 Fields:
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AnimalsCells
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Interface peptide of Alzheimer's amyloid beta: application in purification. Biochem Biophys Res Commun. 2007 Oct 19; 362(2):538-42.
Das U, Hariprasad G, Pasha S, Mann A, Ganguli M, Sharma S, Kaur P, Singh TP, Srinivasan A. PMID: 17707778.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Crystal structure of a secretory signalling glycoprotein from sheep at 2.0A resolution. J Struct Biol. 2006 Dec; 156(3):505-16.
Srivastava DB, Ethayathulla AS, Kumar J, Singh N, Sharma S, Das U, Srinivasan A, Singh TP. PMID: 16859926.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells