Utpal Das

Title(s)	Associate Project Scientist, Neurosciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. Elife. 2024 Jul 19; 12. Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MCQ, Franco ML, Özcan B, Gomes Moreira D, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L. PMID: 39027984; PMCID: PMC11259434.

View in: PubMed Mentions: 1 Fields:
Bio Biology
Translation:Humans Animals Cells
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. bioRxiv. 2024 Apr 23. Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MC, Franco ML, Özcan B, Moreira DG, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L. PMID: 37577527; PMCID: PMC10418207.

View in: PubMed Mentions:
Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function. Neuron. 2023 Dec 20; 111(24):4006-4023.e10. Parra-Rivas LA, Madhivanan K, Aulston BD, Wang L, Prakashchand DD, Boyer NP, Saia-Cereda VM, Branes-Guerrero K, Pizzo DP, Bagchi P, Sundar VS, Tang Y, Das U, Scott DA, Rangamani P, Ogawa Y. PMID: 38128479; PMCID: PMC10766085.

View in: PubMed Mentions: 40 Fields:
Neu Neurology
Translation:Humans Cells
Clathrin packets move in slow axonal transport and deliver functional payloads to synapses. Neuron. 2021 09 15; 109(18):2884-2901.e7. Ganguly A, Sharma R, Boyer NP, Wernert F, Phan S, Boassa D, Parra L, Das U, Caillol G, Han X, Yates JR, Ellisman MH, Leterrier C, Roy S. PMID: 34534453; PMCID: PMC8457040.

View in: PubMed Mentions: 9 Fields:
Neu Neurology
Translation:Animals Cells
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. Alzheimers Res Ther. 2021 03 10; 13(1):59. Chen XQ, Das U, Park G, Mobley WC. PMID: 33691783; PMCID: PMC7945332.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Translation:Animals
Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization. Mol Biol Cell. 2021 02 01; 32(3):247-259. Langness VF, van der Kant R, Das U, Wang L, Chaves RDS, Goldstein LSB. PMID: 33296223; PMCID: PMC8098827.

View in: PubMed Mentions: 22 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention? Prog Mol Biol Transl Sci. 2021; 177:109-122. Goldstein LSB, Das U. PMID: 33453937.

View in: PubMed Mentions: 2 Fields:
Mol Molecular Biology
Translation:Humans Cells
Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11113-11115. Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. PMID: 31110017; PMCID: PMC6561242.

View in: PubMed Mentions: 94 Fields:
Sci Science
Translation:Humans Cells
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019 01 03; 10(1):53. Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. PMID: 30604771; PMCID: PMC6318289.

View in: PubMed Mentions: 51 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory. J Neurosci. 2017 07 19; 37(29):6926-6937. Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. PMID: 28626017; PMCID: PMC5518421.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Translation:Animals
Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 07 03; 216(7):2059-2074. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR, Roy S. PMID: 28559423; PMCID: PMC5496608.

View in: PubMed Mentions: 14 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089; PMCID: PMC4782935.

View in: PubMed Mentions: 97 Fields:
Neu Neurology
Translation:Animals Cells
α-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol. 2014 Oct 06; 24(19):2319-26. Wang L, Das U, Scott DA, Tang Y, McLean PJ, Roy S. PMID: 25264250; PMCID: PMC4190006.

View in: PubMed Mentions: 142 Fields:
Bio Biology
Translation:Humans Animals Cells
Fast vesicle transport is required for the slow axonal transport of synapsin. J Neurosci. 2013 Sep 25; 33(39):15362-75. Tang Y, Scott D, Das U, Gitler D, Ganguly A, Roy S. PMID: 24068803; PMCID: PMC3782618.

View in: PubMed Mentions: 26 Fields:
Neu Neurology
Translation:Animals Cells
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. PMID: 23931995; PMCID: PMC3741682.

View in: PubMed Mentions: 127 Fields:
Neu Neurology
Translation:Animals Cells
The slow axonal transport of alpha-synuclein--mechanistic commonalities amongst diverse cytosolic cargoes. Cytoskeleton (Hoboken). 2012 Jul; 69(7):506-13. Tang Y, Das U, Scott DA, Roy S. PMID: 22344896; PMCID: PMC3376189.

View in: PubMed Mentions: 19 Fields:
Cel Cell Biology
Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic. 2012 May; 13(5):681-93. Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S. PMID: 22309053; PMCID: PMC3593673.

View in: PubMed Mentions: 32 Fields:
Phy Physiology
Translation:Animals Cells
Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron. 2011 May 12; 70(3):441-54. Scott DA, Das U, Tang Y, Roy S. PMID: 21555071; PMCID: PMC3096075.

View in: PubMed Mentions: 52 Fields:
Neu Neurology
Domain organization and function in GluK2 subtype kainate receptors. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8463-8. Das U, Kumar J, Mayer ML, Plested AJ. PMID: 20404149; PMCID: PMC2889583.

View in: PubMed Mentions: 19 Fields:
Sci Science
Translation:Humans Animals Cells
Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key. PLoS One. 2007 Nov 14; 2(11):e1176. Das U, Hariprasad G, Ethayathulla AS, Manral P, Das TK, Pasha S, Mann A, Ganguli M, Verma AK, Bhat R, Chandrayan SK, Ahmed S, Sharma S, Kaur P, Singh TP, Srinivasan A. PMID: 18000547; PMCID: PMC2064962.

View in: PubMed Mentions: 50 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Interface peptide of Alzheimer's amyloid beta: application in purification. Biochem Biophys Res Commun. 2007 Oct 19; 362(2):538-42. Das U, Hariprasad G, Pasha S, Mann A, Ganguli M, Sharma S, Kaur P, Singh TP, Srinivasan A. PMID: 17707778.

View in: PubMed Mentions: Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Crystal structure of a secretory signalling glycoprotein from sheep at 2.0A resolution. J Struct Biol. 2006 Dec; 156(3):505-16. Srivastava DB, Ethayathulla AS, Kumar J, Singh N, Sharma S, Das U, Srinivasan A, Singh TP. PMID: 16859926.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells