Brian Aguado

Title(s)	Assistant Professor, Bioengineering
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Investigating sex differences in persistent valvular myofibroblast activation using hydrogel culture substrates
NIH R00HL148542Sep 5, 2021 - Aug 31, 2024
Role: Principal Investigator

Investigating sex differences in persistent valvular myofibroblast activation using hydrogel culture substrates
NIH K99HL148542Aug 1, 2019 - Jul 31, 2021
Role: Principal Investigator

Development of a nanotherapy for aortic valve stenosis
NIH F32HL137256Jul 1, 2017 - Jun 30, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues. bioRxiv. 2024 May 14. Gorashi RM, Baddour T, Chittle SJ, Vélez NEF, Wenning MA, Anseth KS, Mestroni L, Peña B, Guo P, Aguado BA. PMID: 38798394; PMCID: PMC11118428.

View in: PubMed Mentions:
The future of sex and gender in research. Cell. 2024 Mar 14; 187(6):1354-1357. Aguado BA, Jeffries DL, Jordan-Young R, Klein SL, Lett E, Stachenfeld N, Tollkuhn J, Xu X. PMID: 38490178.

View in: PubMed Mentions: Fields:
Cel Cell Biology
Translation:Humans
Human fetal tissue is critical for biomedical research. Stem Cell Reports. 2023 12 12; 18(12):2300-2312. Brumbaugh J, Aguado BA, Lysaght T, Goldstein LSB. PMID: 37977142; PMCID: PMC10724055.

View in: PubMed Mentions: Fields:
Cel Cell Biology
Translation:Humans
Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype. Am J Physiol Heart Circ Physiol. 2024 01 01; 326(1):H61-H73. Felisbino MB, Rubino M, Travers JG, Schuetze KB, Lemieux ME, Anseth KS, Aguado BA, McKinsey TA. PMID: 37889253; PMCID: PMC11213481.

View in: PubMed Mentions: 2 Fields:
Car Cardiology Phy Physiology
Translation:Cells
Equitable hiring strategies towards a diversified faculty. Nat Biomed Eng. 2023 08; 7(8):961-968. Cosgriff-Hernandez EM, Aguado BA, Akpa B, Fleming GC, Moore E, Porras AM, Boyle PM, Chan DD, Chesler N, Christman KL, Desai TA, Harley BAC, Hudalla GA, Killian ML, Maisel K, Maitland KC, Peyton SR, Pruitt BL, Stabenfeldt SE, Stevens KR, Bowden AK. PMID: 37580521.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering
Translation:Humans
Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation. Biomater Sci. 2022 Nov 08; 10(22):6341-6353. Vogt BJ, Peters DK, Anseth KS, Aguado BA. PMID: 36226463; PMCID: PMC9741081.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering The Therapeutics
Translation:Humans Cells
Correction: Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation. Biomater Sci. 2022 Nov 08; 10(22):6627. Vogt BJ, Anseth KS, Aguado BA. PMID: 36281803; PMCID: PMC9641928.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering The Therapeutics
Chemical and molecular tools to probe biological sex differences at multiple length scales. J Mater Chem B. 2022 09 28; 10(37):7089-7098. Félix Vélez NE, Gorashi RM, Aguado BA. PMID: 36043366; PMCID: PMC9632480.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biotechnology Nan Nanotechnology
Translation:Humans
Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling. Bioeng Transl Med. 2022 Sep; 7(3):e10394. Walker CJ, Batan D, Bishop CT, Ramirez D, Aguado BA, Schroeder ME, Crocini C, Schwisow J, Moulton K, Macdougall L, Weiss RM, Allen MA, Dowell R, Leinwand LA, Anseth KS. PMID: 36176599; PMCID: PMC9472021.

View in: PubMed Mentions: 9
Osteopontin activity modulates sex-specific calcification in engineered valve tissue mimics. Bioeng Transl Med. 2023 Jan; 8(1):e10358. Schroeder ME, Batan D, Gonzalez Rodriguez A, Speckl KF, Peters DK, Kirkpatrick BE, Hach GK, Walker CJ, Grim JC, Aguado BA, Weiss RM, Anseth KS. PMID: 36684107; PMCID: PMC9842038.

View in: PubMed Mentions: 2
Hydrogel cultures reveal Transient Receptor Potential Vanilloid 4 regulation of myofibroblast activation and proliferation in valvular interstitial cells. FASEB J. 2022 05; 36(5):e22306. Batan D, Peters DK, Schroeder ME, Aguado BA, Young MW, Weiss RM, Anseth KS. PMID: 35385164; PMCID: PMC9009405.

View in: PubMed Mentions: 6 Fields:
Bio Biology Phy Physiology
Translation:Animals Cells
Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). Rogers JD, Aguado BA, Watts KM, Anseth KS, Richardson WJ. PMID: 35181609; PMCID: PMC8872767.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Humans Cells
Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts. Circulation. 2022 02 15; 145(7):513-530. Aguado BA, Walker CJ, Grim JC, Schroeder ME, Batan D, Vogt BJ, Rodriguez AG, Schwisow JA, Moulton KS, Weiss RM, Heistad DD, Leinwand LA, Anseth KS. PMID: 35000411; PMCID: PMC8844107.

View in: PubMed Mentions: 24 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals Cells
Author Correction: Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts. Nat Biomed Eng. 2021 Dec; 5(12):1517-1518. Walker CJ, Crocini C, Ramirez D, Killaars AR, Grim JC, Aguado BA, Clark K, Allen MA, Dowell RD, Leinwand LA, Anseth KS. PMID: 34050334.

View in: PubMed Mentions: 5 Fields:
Bio Biomedical Engineering
Matters of the heart: Cellular sex differences. J Mol Cell Cardiol. 2021 11; 160:42-55. Walker CJ, Schroeder ME, Aguado BA, Anseth KS, Leinwand LA. PMID: 34166708; PMCID: PMC8571046.

View in: PubMed Mentions: 30 Fields:
Car Cardiology Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts. Nat Biomed Eng. 2021 12; 5(12):1485-1499. Walker CJ, Crocini C, Ramirez D, Killaars AR, Grim JC, Aguado BA, Clark K, Allen MA, Dowell RD, Leinwand LA, Anseth KS. PMID: 33875841; PMCID: PMC9102466.

View in: PubMed Mentions: 42 Fields:
Bio Biomedical Engineering
Translation:Humans Animals Cells
Building a virtual community to support and celebrate the success of Latinx scientists. Nat Rev Mater. 2020; 5(12):862-864. Aguado BA, Porras AM. PMID: 33101711; PMCID: PMC7574393.

View in: PubMed Mentions: 3
Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):e296-e308. Grim JC, Aguado BA, Vogt BJ, Batan D, Andrichik CL, Schroeder ME, Gonzalez-Rodriguez A, Yavitt FM, Weiss RM, Anseth KS. PMID: 32938214; PMCID: PMC7578003.

View in: PubMed Mentions: 27 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments. Adv Funct Mater. 2020 Sep 10; 30(37). Caldwell AS, Aguado BA, Anseth KS. PMID: 33841061; PMCID: PMC8026140.

View in: PubMed Mentions: 31
Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med. 2019 09 11; 11(509). Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. PMID: 31511425; PMCID: PMC6754739.

View in: PubMed Mentions: 28 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications. ACS Appl Mater Interfaces. 2019 May 22; 11(20):18671-18680. Peña B, Maldonado M, Bonham AJ, Aguado BA, Dominguez-Alfaro A, Laughter M, Rowland TJ, Bardill J, Farnsworth NL, Alegret Ramon N, Taylor MRG, Anseth KS, Prato M, Shandas R, McKinsey TA, Park D, Mestroni L. PMID: 31021594; PMCID: PMC6764451.

View in: PubMed Mentions: 11 Fields:
Bio Biomedical Engineering Bio Biotechnology
Translation:Animals Cells
A Reversible and Repeatable Thiol-Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels. ACS Cent Sci. 2018 Jul 25; 4(7):909-916. Grim JC, Brown TE, Aguado BA, Chapnick DA, Viert AL, Liu X, Anseth KS. PMID: 30062120; PMCID: PMC6062832.

View in: PubMed Mentions: 50
Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment. Adv Healthc Mater. 2018 05; 7(10):e1700903. Aguado BA, Hartfield RM, Bushnell GG, Decker JT, Azarin SM, Nanavati D, Schipma MJ, Rao SS, Oakes RS, Zhang Y, Jeruss JS, Shea LD. PMID: 29521008; PMCID: PMC6014830.

View in: PubMed Mentions: 19 Fields:
Bio Biomedical Engineering Tec Technology
Translation:Humans Animals Cells
Engineering precision biomaterials for personalized medicine. Sci Transl Med. 2018 01 17; 10(424). Aguado BA, Grim JC, Rosales AM, Watson-Capps JJ, Anseth KS. PMID: 29343626; PMCID: PMC6079507.

View in: PubMed Mentions: 61 Fields:
Med Medicine (General)Sci Science
Translation:Humans
Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation. ACS Appl Mater Interfaces. 2017 Sep 20; 9(37):31645-31656. Peña B, Bosi S, Aguado BA, Borin D, Farnsworth NL, Dobrinskikh E, Rowland TJ, Martinelli V, Jeong M, Taylor MRG, Long CS, Shandas R, Sbaizero O, Prato M, Anseth KS, Park D, Mestroni L. PMID: 28895403; PMCID: PMC5672802.

View in: PubMed Mentions: 22 Fields:
Bio Biomedical Engineering Bio Biotechnology
Translation:Animals Cells
Engineering the pre-metastatic niche. Nat Biomed Eng. 2017; 1. Aguado BA, Bushnell GG, Rao SS, Jeruss JS, Shea LD. PMID: 28989814; PMCID: PMC5628747.

View in: PubMed Mentions: 63 Fields:
Bio Biomedical Engineering
Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. Cancer Res. 2016 09 15; 76(18):5209-18. Rao SS, Bushnell GG, Azarin SM, Spicer G, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Shea LD, Jeruss JS. PMID: 27635043; PMCID: PMC5027988.

View in: PubMed Mentions: 40 Fields:
Neo Neoplasms
Translation:Animals
Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. J Cell Biol. 2016 Feb 15; 212(4):425-38. Dubash AD, Kam CY, Aguado BA, Patel DM, Delmar M, Shea LD, Green KJ. PMID: 26858265; PMCID: PMC4754716.

View in: PubMed Mentions: 57 Fields:
Cel Cell Biology
Translation:Animals Cells
Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche. Acta Biomater. 2016 Mar; 33:13-24. Aguado BA, Caffe JR, Nanavati D, Rao SS, Bushnell GG, Azarin SM, Shea LD. PMID: 26844426; PMCID: PMC4777643.

View in: PubMed Mentions: 35 Fields:
Bio Biomedical Engineering
Translation:Humans Animals Cells
Secretome identification of immune cell factors mediating metastatic cell homing. Sci Rep. 2015 Dec 04; 5:17566. Aguado BA, Wu JJ, Azarin SM, Nanavati D, Rao SS, Bushnell GG, Medicherla CB, Shea LD. PMID: 26634905; PMCID: PMC4669442.

View in: PubMed Mentions: 15 Fields:
Sci Science
Translation:Humans Animals Cells
In vivo capture and label-free detection of early metastatic cells. Nat Commun. 2015 Sep 08; 6:8094. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. PMID: 26348915; PMCID: PMC4563812.

View in: PubMed Mentions: 62 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Osteogenic potential of BMP-2-releasing self-assembled membranes. Tissue Eng Part A. 2013 Dec; 19(23-24):2664-73. Chung EJ, Chien KB, Aguado BA, Shah RN. PMID: 23790163; PMCID: PMC3856670.

View in: PubMed Mentions: 9 Fields:
Bio Biotechnology His Histology
Translation:Humans Animals Cells
In vivo acute and humoral response to three-dimensional porous soy protein scaffolds. Acta Biomater. 2013 Nov; 9(11):8983-90. Chien KB, Aguado BA, Bryce PJ, Shah RN. PMID: 23851173.

View in: PubMed Mentions: 11 Fields:
Bio Biomedical Engineering
Translation:Animals
Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Tissue Eng Part A. 2012 Apr; 18(7-8):806-15. Aguado BA, Mulyasasmita W, Su J, Lampe KJ, Heilshorn SC. PMID: 22011213; PMCID: PMC3313609.

View in: PubMed Mentions: 233 Fields:
Bio Biotechnology His Histology
Translation:Humans Cells