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    Anna Di Nardo

    TitleProfessor Of Clinical
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0869
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Bacterial Mast cell conditioning modulates skin allergic reactions
      NIH/NIAID R21AI123729Aug 20, 2016 - Jul 31, 2018
      Role: Principal Investigator
      The Microbiome Drives Masts Cell Recruitment in the Skin
      NIH/NIAID R01AI106874Nov 1, 2014 - Oct 31, 2019
      Role: Principal Investigator
      The Microbiome Drives Mast Cell Recruitment in the Skin
      NIH/NIAID R56AI106874Jul 18, 2013 - Jun 30, 2014
      Role: Principal Investigator
      Mast cells in skin innate immune defense
      NIH/NIAID R01AI093957Apr 1, 2011 - Mar 31, 2016
      Role: Principal Investigator
      Mast cell controls pathogen entrance by the expression of antimicrobial peptides
      NIH/NIAID R21AI074766Jul 15, 2008 - Jun 30, 2011
      Role: Principal Investigator

      Collapse ORNG Applications 
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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bernard Q, Wang Z, Di Nardo A, Boulanger N. Interaction of primary mast cells with Borrelia burgdorferi (sensu stricto): role in transmission and dissemination in C57BL/6 mice. Parasit Vectors. 2017 Jun 27; 10(1):313. PMID: 28655322.
        View in: PubMed
      2. Igawa S, Di Nardo A. Skin microbiome and mast cells. Transl Res. 2017 Jun; 184:68-76. PMID: 28390799.
        View in: PubMed
      3. Mascarenhas NL, Wang Z, Chang YL, Di Nardo A. TRPV4 Mediates Mast Cell Activation in Cathelicidin-Induced Rosacea Inflammation. J Invest Dermatol. 2017 Apr; 137(4):972-975. PMID: 27908695.
        View in: PubMed
      4. Wang Z, Mascarenhas N, Eckmann L, Miyamoto Y, Sun X, Kawakami T, Di Nardo A. Skin microbiome promotes mast cell maturation by triggering stem cell factor (SCF) production in keratinocytes. J Allergy Clin Immunol. 2016 Oct 13. PMID: 27746235.
        View in: PubMed
      5. Docherty JR, Steinhoff M, Lorton D, Detmar M, Schäfer G, Holmes A, Di Nardo A. Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. Adv Ther. 2016 Nov; 33(11):1885-1895. PMID: 27562835.
        View in: PubMed
      6. Di Nardo A, Holmes AD, Muto Y, Huang EY, Preston N, Winkelman WJ, Gallo RL. Improved clinical outcome and biomarkers in adults with papulopustular rosacea treated with doxycycline modified-release capsules in a randomized trial. J Am Acad Dermatol. 2016 Jun; 74(6):1086-92. PMID: 26951940.
        View in: PubMed
      7. Muto Y, Wang Z, Vanderberghe M, Two A, Gallo RL, Di Nardo A. Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea. J Invest Dermatol. 2014 Nov; 134(11):2728-2736. PMID: 24844861; PMCID: PMC4199909.
      8. Wang Z, MacLeod DT, Di Nardo A. Commensal bacteria lipoteichoic acid increases skin mast cell antimicrobial activity against vaccinia viruses. J Immunol. 2012 Aug 15; 189(4):1551-8. PMID: 22772452; PMCID: PMC3411879.
      9. Breithaupt AD, Di Nardo A, Kempiak SJ. What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). Cutis. 2012 Jul; 90(1):13, 24-5. PMID: 22908727.
        View in: PubMed
      10. Wang Z, Lai Y, Bernard JJ, Macleod DT, Cogen AL, Moss B, Di Nardo A. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides. J Immunol. 2012 Jan 01; 188(1):345-57. PMID: 22140255; PMCID: PMC3244574.
      11. Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, Arai N, Gallo RL, Digiovanni J, Gilliet M. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med. 2010 Dec 20; 207(13):2921-30. PMID: 21115688; PMCID: PMC3005239.
      12. Alexandrescu DT, Ichim TE, Riordan NH, Marincola FM, Di Nardo A, Kabigting FD, Dasanu CA. Immunotherapy for melanoma: current status and perspectives. J Immunother. 2010 Jul-Aug; 33(6):570-90. PMID: 20551839; PMCID: PMC3517185.
      13. Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol. 2010 Sep; 130(9):2211-21. PMID: 20463690; PMCID: PMC2922455.
      14. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009 Dec; 15(12):1377-82. PMID: 19966777; PMCID: PMC2880863.
      15. Park HJ, Cho DH, Kim HJ, Lee JY, Cho BK, Bang SI, Song SY, Yamasaki K, Di Nardo A, Gallo RL. Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37. J Invest Dermatol. 2009 Apr; 129(4):843-50. PMID: 18923445; PMCID: PMC2665190.
      16. Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL. Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J Immunol. 2008 Jun 01; 180(11):7565-73. PMID: 18490758; PMCID: PMC2664112.
      17. Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007 Aug; 13(8):975-80. PMID: 17676051.
        View in: PubMed
      18. Taylor KR, Yamasaki K, Radek KA, Di Nardo A, Goodarzi H, Golenbock D, Beutler B, Gallo RL. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem. 2007 Jun 22; 282(25):18265-75. PMID: 17400552.
        View in: PubMed
      19. Di Nardo A, Braff MH, Taylor KR, Na C, Granstein RD, McInturff JE, Krutzik S, Modlin RL, Gallo RL. Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization. J Immunol. 2007 Feb 01; 178(3):1829-34. PMID: 17237433.
        View in: PubMed
      20. Granstein RD, Ding W, Huang J, Holzer A, Gallo RL, Di Nardo A, Wagner JA. Augmentation of cutaneous immune responses by ATP gamma S: purinergic agonists define a novel class of immunologic adjuvants. J Immunol. 2005 Jun 15; 174(12):7725-31. PMID: 15944274.
        View in: PubMed
      21. Braff MH, Hawkins MA, Di Nardo A, Lopez-Garcia B, Howell MD, Wong C, Lin K, Streib JE, Dorschner R, Leung DY, Gallo RL. Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities. J Immunol. 2005 Apr 01; 174(7):4271-8. PMID: 15778390.
        View in: PubMed
      22. Braff MH, Di Nardo A, Gallo RL. Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies. J Invest Dermatol. 2005 Feb; 124(2):394-400. PMID: 15675959.
        View in: PubMed
      23. Di Nardo A, Vitiello A, Gallo RL. Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide. J Immunol. 2003 Mar 01; 170(5):2274-8. PMID: 12594247.
        View in: PubMed
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