Wolfgang Junger

Title(s)Professor, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic and purinergic immune regulation
    NIH R35GM136429Apr 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Role of purinergic signaling in pediatric multi-organ failure
    NIH R01HD098363Mar 20, 2019 - Feb 29, 2024
    Role: Principal Investigator
    Harvard Trauma Inflammation Training Program
    NIH T32GM103702Jul 1, 2013 - Jun 30, 2019
    Role: Principal Investigator
    Autocrine regulation of neutrophil chemotaxis
    NIH R01GM116162Jun 15, 2009 - Apr 30, 2020
    Role: Principal Investigator
    Purinergic receptors in inflammation
    NIH R01AI080582Jun 15, 2009 - May 31, 2014
    Role: Principal Investigator
    Autocrine control of neutrophil chemotaxis
    NIH R01AI072287May 15, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Neutrophil activation and trauma
    NIH R01GM060475Dec 1, 1999 - Nov 30, 2017
    Role: Principal Investigator
    Purinergic regulation of T cells
    NIH R01GM051477Jun 1, 1996 - Jul 31, 2018
    Role: Principal Investigator
    HYPERTONIC SALINE AND IMMUNE FUNCTION
    NIH R29GM051477Jun 1, 1996 - May 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Editorial overview: "Purinergic immune cell regulation reveals novel pharmacological targets". Curr Opin Pharmacol. 2024 Apr; 75:102435. Junger W, Ledderose C. PMID: 38277943.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. ATP release from influenza-infected lungs enhances neutrophil activation and promotes disease progression. J Infect Dis. 2023 Oct 06. Ledderose C, Valsami EA, Elevado M, Junger WG. PMID: 37804120.
      View in: PubMed   Mentions:    Fields:    
    3. P2X1 and P2X7 Receptor Overexpression Is a Negative Predictor of Survival in Muscle-Invasive Bladder Cancer. Cancers (Basel). 2023 Apr 16; 15(8). Ledderose S, Rodler S, Eismann L, Ledderose G, Rudelius M, Junger WG, Ledderose C. PMID: 37190249; PMCID: PMC10136747.
      View in: PubMed   Mentions: 3  
    4. ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils. Purinergic Signal. 2023 Dec; 19(4):651-662. Ledderose C, Valsami EA, Newhams M, Elevado MJ, Novak T, Randolph AG, Junger WG. PMID: 36596963; PMCID: PMC10754799.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Optimized flow cytometry assays to monitor neutrophil activation in human and mouse whole blood samples. J Immunol Methods. 2023 01; 512:113403. Ledderose C, Hashiguchi N, Valsami EA, Rusu C, Junger WG. PMID: 36502881.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Correction: Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2022 Oct 19; 13:1153-1154. de Andrade Mello P, Bian S, Savio LEB, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. PMID: 36264079; PMCID: PMC9584421.
      View in: PubMed   Mentions:    Fields:    
    7. Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39. Thorax. 2023 02; 78(2):151-159. Tiwari-Heckler S, Lee GR, Harbison J, Ledderose C, Csizmadia E, Melton D, Zhang Q, Junger W, Chen G, Hauser CJ, Otterbein LE, Longhi MS, Robson SC. PMID: 35613855; PMCID: PMC9691787.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood. Purinergic Signal. 2022 06; 18(2):223-239. Ledderose C, Valsami EA, Junger WG. PMID: 35132577; PMCID: PMC9123122.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C15-C29. Zhong EH, Ledderose C, De Andrade Mello P, Enjyoji K, Lunderberg JM, Junger W, Robson SC. PMID: 33052071; PMCID: PMC7846972.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. Negative feedback control of neuronal activity by microglia. Nature. 2020 10; 586(7829):417-423. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. PMID: 32999463; PMCID: PMC7577179.
      View in: PubMed   Mentions: 285     Fields:    Translation:HumansAnimalsCells
    11. Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function. Front Immunol. 2020; 11:549889. Ledderose C, Junger WG. PMID: 33133068; PMCID: PMC7550529.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes. Sci Signal. 2020 09 29; 13(651). Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Aytan D, Shen Y, Junger WG. PMID: 32994212; PMCID: PMC8826773.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    13. Adenosine 5'-Monophosphate Protects from Hypoxia by Lowering Mitochondrial Metabolism and Oxygen Demand. Shock. 2020 08; 54(2):237-244. Kondo Y, Sueyoshi K, Zhang J, Bao Y, Li X, Fakhari M, Slubowski CJ, Bahrami S, Ledderose C, Junger WG. PMID: 31460871; PMCID: PMC7044067.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse. J Leukoc Biol. 2021 03; 109(3):497-508. Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Junger WG. PMID: 32531829; PMCID: PMC8772287.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Author Correction: NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2020 06 10; 11(1):3036. Bai A, Moss A, Rothweiler S, Longhi MS, Wu Y, Junger WG, Robson SC. PMID: 32522986; PMCID: PMC7287065.
      View in: PubMed   Mentions:    Fields:    
    16. RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. J Allergy Clin Immunol. 2020 06; 145(6):1673-1680.e11. Novak T, Hall MW, McDonald DR, Newhams MM, Mistry AJ, Panoskaltsis-Mortari A, Mourani PM, Loftis LL, Weiss SL, Tarquinio KM, Markovitz B, Hartman ME, Schwarz A, Junger WG, Randolph AG, PALISI Pediatric Intensive Care Influenza (PICFLU) Network Investigators. PMID: 32035159; PMCID: PMC7323584.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020 01 17; 5(43). Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG. PMID: 31953256; PMCID: PMC7176051.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    18. Frontline Science: Escherichia coli use LPS as decoy to impair neutrophil chemotaxis and defeat antimicrobial host defense. J Leukoc Biol. 2019 12; 106(6):1211-1219. Kondo Y, Ledderose C, Slubowski CJ, Fakhari M, Sumi Y, Sueyoshi K, Bezler AK, Aytan D, Arbab M, Junger WG. PMID: 31392789; PMCID: PMC6883117.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Purinergic P2Y2 receptors modulate endothelial sprouting. Cell Mol Life Sci. 2020 Mar; 77(5):885-901. Mühleder S, Fuchs C, Basílio J, Szwarc D, Pill K, Labuda K, Slezak P, Siehs C, Pröll J, Priglinger E, Hoffmann C, Junger WG, Redl H, Holnthoner W. PMID: 31278420.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    20. Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality. Shock. 2019 06; 51(6):698-705. Sumi Y, Ledderose C, Li L, Inoue Y, Okamoto K, Kondo Y, Sueyoshi K, Junger WG, Tanaka H. PMID: 30052576; PMCID: PMC6347542.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    21. Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation. Purinergic Signal. 2019 06; 15(2):127-137. Woehrle T, Ledderose C, Rink J, Slubowski C, Junger WG. PMID: 30919205; PMCID: PMC6635541.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors. J Biol Chem. 2019 04 19; 294(16):6283-6293. Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG. PMID: 30787105; PMCID: PMC6484120.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1β Production, and the Host Immune Response to Infection. Crit Care Med. 2018 12; 46(12):e1183-e1189. Lee AH, Ledderose C, Li X, Slubowski CJ, Sueyoshi K, Staudenmaier L, Bao Y, Zhang J, Junger WG. PMID: 30247270; PMCID: PMC6239954.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    24. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 08 01; 128(8):3583-3594. Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG. PMID: 29894310; PMCID: PMC6063471.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    25. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017 Sep 15; 8(40):67254-67268. de Andrade Mello P, Bian S, Savio LEB, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. PMID: 28978031; PMCID: PMC5620171.
      View in: PubMed   Mentions: 23     Fields:    
    26. Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis. Crit Care Med. 2017 Jan; 45(1):e97-e104. Li X, Kondo Y, Bao Y, Staudenmaier L, Lee A, Zhang J, Ledderose C, Junger WG. PMID: 27548819; PMCID: PMC5546305.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    27. Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate. J Exp Clin Cancer Res. 2016 10 03; 35(1):161. Qi B, Yu T, Wang C, Wang T, Yao J, Zhang X, Deng P, Xia Y, Junger WG, Sun D. PMID: 27716441; PMCID: PMC5048460.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016 12; 12(4):673-685. Ledderose C, Hefti MM, Chen Y, Bao Y, Seier T, Li L, Woehrle T, Zhang J, Junger WG. PMID: 27577957; PMCID: PMC5124008.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Purinergic Signaling and the Immune Response in Sepsis: A Review. Clin Ther. 2016 05; 38(5):1054-65. Ledderose C, Bao Y, Kondo Y, Fakhari M, Slubowski C, Zhang J, Junger WG. PMID: 27156007; PMCID: PMC4875817.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    30. Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling? Purinergic Signal. 2016 09; 12(3):439-51. Ledderose C, Woehrle T, Ledderose S, Strasser K, Seist R, Bao Y, Zhang J, Junger WG. PMID: 27020575; PMCID: PMC5023625.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    31. NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2015 Nov 09; 6:8819. Bai A, Moss A, Rothweiler S, Serena Longhi M, Wu Y, Junger WG, Robson SC. PMID: 26549640; PMCID: PMC4667632.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    32. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. PMID: 26485519; PMCID: PMC4618999.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    33. mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis. J Cell Biol. 2015 Sep 28; 210(7):1153-64. Bao Y, Ledderose C, Graf AF, Brix B, Birsak T, Lee A, Zhang J, Junger WG. PMID: 26416965; PMCID: PMC4586745.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    34. Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases. Shock. 2015 Sep; 44(3):221-7. Chen Y, Bao Y, Zhang J, Woehrle T, Sumi Y, Ledderose S, Li X, Ledderose C, Junger WG. PMID: 26009814; PMCID: PMC4537693.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    35. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. PMID: 26150546; PMCID: PMC4704665.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    36. Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis. Shock. 2015 Jul; 44(1):25-31. Delano MJ, Rizoli SB, Rhind SG, Cuschieri J, Junger W, Baker AJ, Dubick MA, Hoyt DB, Bulger EM. PMID: 25784523; PMCID: PMC4607051.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    37. Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation. J Biol Chem. 2014 Sep 26; 289(39):27090-27104. Weihs AM, Fuchs C, Teuschl AH, Hartinger J, Slezak P, Mittermayr R, Redl H, Junger WG, Sitte HH, Rünzler D. PMID: 25118288; PMCID: PMC4175346.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    38. Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling. J Biol Chem. 2014 Sep 26; 289(39):26794-26803. Bao Y, Ledderose C, Seier T, Graf AF, Brix B, Chong E, Junger WG. PMID: 25104353; PMCID: PMC4175322.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCellsCTClinical Trials
    39. Plasma ATP is required for neutrophil activation in a mouse sepsis model. Shock. 2014 Aug; 42(2):142-7. Sumi Y, Woehrle T, Chen Y, Bao Y, Li X, Yao Y, Inoue Y, Tanaka H, Junger WG. PMID: 24675414; PMCID: PMC4107005.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    40. Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem. 2014 Sep 12; 289(37):25936-45. Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG. PMID: 25070895; PMCID: PMC4162192.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    41. Abandon the mouse research ship? Not just yet! Shock. 2014 Jun; 41(6):463-75. Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH. PMID: 24569509; PMCID: PMC4139038.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    42. Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury. Shock. 2013 Nov; 40(5):366-74. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Baker AJ, Shek PN, Hoyt DB, Bulger EM. PMID: 24088993; PMCID: PMC3913169.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    43. Monocyte human leukocyte antigen-DR expression-a tool to distinguish intestinal bacterial infections from inflammatory bowel disease? Shock. 2013 Aug; 40(2):89-94. Tillinger W, Jilch R, Waldhoer T, Reinisch W, Junger W. PMID: 23860582; PMCID: PMC4243300.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    44. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013 Aug 02; 288(31):22650-7. Bao Y, Chen Y, Ledderose C, Li L, Junger WG. PMID: 23798685; PMCID: PMC3829350.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    45. Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors. Stem Cells. 2013 Jun; 31(6):1170-80. Sun D, Junger WG, Yuan C, Zhang W, Bao Y, Qin D, Wang C, Tan L, Qi B, Zhu D, Zhang X, Yu T. PMID: 23404811; PMCID: PMC4243484.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    46. Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):601-9. Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC. PMID: 23349052; PMCID: PMC3707383.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    47. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS One. 2013; 8(4):e60184. Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, Junger WG, Robson SC, Wu Y. PMID: 23565201; PMCID: PMC3615040.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    48. CD39 modulates hematopoietic stem cell recruitment and promotes liver regeneration in mice and humans after partial hepatectomy. Ann Surg. 2013 Apr; 257(4):693-701. Schmelzle M, Duhme C, Junger W, Salhanick SD, Chen Y, Wu Y, Toxavidis V, Csizmadia E, Han L, Bian S, Fürst G, Nowak M, Karp SJ, Knoefel WT, Esch JSA, Robson SC. PMID: 23474584; PMCID: PMC4243517.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    49. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology. 2013 Jan; 57(1):205-16. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC. PMID: 22859060; PMCID: PMC3505255.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    50. Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation. Shock. 2012 Oct; 38(4):341-50. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, Li L, Shek PN, Hoyt DB, Bulger EM. PMID: 22777113; PMCID: PMC3455119.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    51. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol. 2012 Oct; 92(4):787-94. Manohar M, Hirsh MI, Chen Y, Woehrle T, Karande AA, Junger WG. PMID: 22753954; PMCID: PMC3441317.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    52. Measurement of oxidative burst in neutrophils. Methods Mol Biol. 2012; 844:115-24. Chen Y, Junger WG. PMID: 22262438; PMCID: PMC4214271.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    53. Bacterial DNA induces pulmonary damage via TLR-9 through cross-talk with neutrophils. Shock. 2011 Dec; 36(6):548-52. Itagaki K, Adibnia Y, Sun S, Zhao C, Sursal T, Chen Y, Junger W, Hauser CJ. PMID: 21937948; PMCID: PMC3220777.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    54. Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients. Shock. 2011 Nov; 36(5):435-9. Bulger EM, Tower CM, Warner KJ, Garland T, Cuschieri J, Rizoli S, Rhind S, Junger WG. PMID: 21841534; PMCID: PMC3204900.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    55. Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol. 2011 Mar; 11(3):201-12. Junger WG. PMID: 21331080; PMCID: PMC4209705.
      View in: PubMed   Mentions: 376     Fields:    Translation:HumansAnimalsCells
    56. A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation. Shock. 2011 Feb; 35(2):178-83. Inoue Y, Tanaka H, Sumi Y, Woehrle T, Chen Y, Hirsh MI, Junger WG. PMID: 20661181; PMCID: PMC3038630.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    57. Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors. J Leukoc Biol. 2010 Dec; 88(6):1181-9. Woehrle T, Yip L, Manohar M, Sumi Y, Yao Y, Chen Y, Junger WG. PMID: 20884646; PMCID: PMC2996895.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    58. Adrenergic receptor activation involves ATP release and feedback through purinergic receptors. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1118-26. Sumi Y, Woehrle T, Chen Y, Yao Y, Li A, Junger WG. PMID: 20668211; PMCID: PMC2980303.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    59. Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood. 2010 Nov 04; 116(18):3475-84. Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG. PMID: 20660288; PMCID: PMC2981474.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    60. Purinergic signaling: a fundamental mechanism in neutrophil activation. Sci Signal. 2010 Jun 08; 3(125):ra45. Chen Y, Yao Y, Sumi Y, Li A, To UK, Elkhal A, Inoue Y, Woehrle T, Zhang Q, Hauser C, Junger WG. PMID: 20530802; PMCID: PMC4209711.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    61. Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology. 2010 May; 51(5):1702-11. Beldi G, Banz Y, Kroemer A, Sun X, Wu Y, Graubardt N, Rellstab A, Nowak M, Enjyoji K, Li X, Junger WG, Candinas D, Robson SC. PMID: 20146261; PMCID: PMC2903010.
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    62. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010 Mar 04; 464(7285):104-7. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. PMID: 20203610; PMCID: PMC2843437.
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    63. Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C457-64. Yu T, Junger WG, Yuan C, Jin A, Zhao Y, Zheng X, Zeng Y, Liu J. PMID: 19889958; PMCID: PMC4631534.
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    64. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J. 2009 Jun; 23(6):1685-93. Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG. PMID: 19211924; PMCID: PMC2718802.
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    65. Hypertonic saline increases gammadeltaT cell-mediated killing of activated neutrophils. Crit Care Med. 2008 Dec; 36(12):3220-5. Hirsh MI, Hashiguchi N, Junger WG. PMID: 18936699; PMCID: PMC4212635.
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    66. Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis. Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6):R1839-45. Tillinger W, McCole DF, Keely SJ, Bertelsen LS, Wolf PL, Junger WG, Barrett KE. PMID: 18832091; PMCID: PMC2685287.
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    67. Hypertonic saline up-regulates A3 adenosine receptor expression of activated neutrophils and increases acute lung injury after sepsis. Crit Care Med. 2008 Sep; 36(9):2569-75. Inoue Y, Chen Y, Pauzenberger R, Hirsh MI, Junger WG. PMID: 18679117; PMCID: PMC2643471.
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    68. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17; 283(42):28480-6. Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. PMID: 18713747; PMCID: PMC2568933.
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    69. A3 and P2Y2 receptors control the recruitment of neutrophils to the lungs in a mouse model of sepsis. Shock. 2008 Aug; 30(2):173-7. Inoue Y, Chen Y, Hirsh MI, Yip L, Junger WG. PMID: 18091570; PMCID: PMC4212521.
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    70. Roles of heat shock proteins and gamma delta T cells in inflammation. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):509-13. Hirsh MI, Junger WG. PMID: 18566334; PMCID: PMC2574523.
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    71. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1420-5. Corriden R, Insel PA, Junger WG. PMID: 17699635.
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    72. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J. 2007 Nov; 21(13):3717-26. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. PMID: 17575258.
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    73. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine. Shock. 2007 Mar; 27(3):242-50. Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. PMID: 17304104.
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    74. Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients. J Trauma. 2007 Feb; 62(2):299-306. Hashiguchi N, Lum L, Romeril E, Chen Y, Yip L, Hoyt DB, Junger WG. PMID: 17297316.
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    75. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. PMID: 17170310.
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    76. Small-volume fluid resuscitation with hypertonic saline prevents inflammation but not mortality in a rat model of hemorrhagic shock. Shock. 2006 Mar; 25(3):283-9. Bahrami S, Zimmermann K, Szelényi Z, Hamar J, Scheiflinger F, Redl H, Junger WG. PMID: 16552361.
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    77. Surface expression of HSP72 by LPS-stimulated neutrophils facilitates gammadeltaT cell-mediated killing. Eur J Immunol. 2006 Mar; 36(3):712-21. Hirsh MI, Hashiguchi N, Chen Y, Yip L, Junger WG. PMID: 16482515.
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    78. Hypertonic saline enhances neutrophil elastase release through activation of P2 and A3 receptors. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1051-9. Chen Y, Hashiguchi N, Yip L, Junger WG. PMID: 16282197.
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    79. Osmotic regulation of cell function and possible clinical applications. Shock. 2004 May; 21(5):391-400. Shukla A, Hashiguchi N, Chen Y, Coimbra R, Hoyt DB, Junger WG. PMID: 15087814.
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    80. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol. 2004 Jul; 76(1):245-53. Chen Y, Shukla A, Namiki S, Insel PA, Junger WG. PMID: 15107462.
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    81. Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock. J Trauma. 2004 Mar; 56(3):501-10; discussion 510-1. Doucet JJ, Hoyt DB, Coimbra R, Schmid-Schönbein GW, Junger WG, Paul L W, Loomis WH, Hugli TE. PMID: 15128119.
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    82. Pentoxifylline reduces acute lung injury in chronic endotoxemia. J Surg Res. 2003 Nov; 115(1):92-9. Michetti C, Coimbra R, Hoyt DB, Loomis W, Junger W, Wolf P. PMID: 14572778.
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    83. Pancreatic enzymes sustain systemic inflammation after an initial endotoxin challenge. Surgery. 2003 Sep; 134(3):446-56. Fitzal F, Delano FA, Young C, Rosario HS, Junger WG, Schmid-Schönbein GW. PMID: 14555932.
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    84. Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Shock. 2003 Jul; 20(1):23-8. Murao Y, Hata M, Ohnishi K, Okuchi K, Nakajima Y, Hiasa Y, Junger WG, Hoyt DB, Ohnishi T. PMID: 12813364.
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    85. Effect of dose of hypertonic saline on its potential to prevent lung tissue damage in a mouse model of hemorrhagic shock. Shock. 2003 Jul; 20(1):29-34. Murao Y, Loomis W, Wolf P, Hoyt DB, Junger WG. PMID: 12813365.
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    86. Hypertonicity promotes survival of corticospinal motoneurons via mitogen-activated protein kinase p38 signaling. J Mol Neurosci. 2003; 21(2):111-20. Junger H, Edelman DB, Junger WG. PMID: 14593211.
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    87. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem. 2003 Feb 14; 278(7):4590-6. Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. PMID: 12464620.
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    88. Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1261-9. Orlic T, Loomis WH, Shreve A, Namiki S, Junger WG. PMID: 11997240.
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