Lilia Iakoucheva

Title(s)Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-4542-5219 Additional info
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Dr. Lilia Iakoucheva is a Professor of Psychiatry at the University of California San Diego. She obtained her B.S. in genetics from Kiev State University in Ukraine, and her Ph.D. from the Institute of Immunology in Russia. After completing postdoctoral training in protein biochemistry at the Pacific Northwest National Laboratory (PNNL), she joined Washington State University to study Intrinsically Disordered Proteins. During that time, she made a series of fundamental discoveries about disordered proteins, including their role in cell signaling and cancer. Several of her papers on disordered proteins are highly cited, and accumulated over a 1500 citations each. Lilia then joined the Rockefeller University studying protein interaction networks and pathways underlying human diseases. She joined Psychiatry Department of UCSD in 2010, and her current research focuses on understanding of the molecular basis of neurodevelopmental diseases, with the focus on autism spectrum disorders. Dr. Iakoucheva has been the Principal Investigator on numerous research grants from NSF, NCI, NICHD, NIGRI, NIEHS and NIMH. She is a Member of the UCSD Bioinformatics and Systems Biology Graduate Program, Biomedical Sciences graduate Program, and an UCSD Institute for Genomic Medicine. She serves as an Associate Editor of PLOS Computational Biology Journal, and has received multiple awards, such as student-nominated Outstanding Faculty Mentor Award, and Outstanding Dedication to Undergraduates award for mentoring high school and undergraduate students.

    Collapse Research 
    Collapse Research Activities and Funding
    Effects of acetaminophen on prenatal brain development: an organoid model
    NIH R21HD109616Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigat
    Rescue of Cul3 haploinsufficiency phenotypes with CRISPR-mediated Cul3 activation
    NIH R21MH128827Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigator
    Cortical organoid models to study autism-associated 16p.11.2.CNV
    NIH R56MH128365Mar 1, 2022 - Feb 28, 2023
    Role: Principal Investigator
    Investigating neurodevelopmental toxicity of perfluoroalkyl acids and their derivatives in human brain organoids models
    NIH R01ES033636Feb 7, 2022 - Nov 30, 2026
    Role: Principal Investigator
    Integrative functional genomic study of pathways impacted by recurrent autism CNV
    NIH R01MH108528Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Evaluating the effect of splicing mutations on isoform networks in autism
    NIH R01MH109885May 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    A computational framework for predicting the impact of mutations in autism
    NIH R01MH105524Sep 25, 2014 - May 31, 2018
    Role: Principal Investigator
    Protein network of high risk copy number variants for psychiatric disorders
    NIH R21MH104766Jul 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Schizophrenia interactome mapping and global discovery of brain splice variants
    NIH R01MH091350May 20, 2010 - Mar 31, 2015
    Role: Principal Investigator
    A systems biology approach to unravel theunderlying functional modules of ASD
    NIH R01HD065288Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Protein structural disorder and ubiquitination
    NIH R21CA113711Aug 2, 2007 - Jul 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain. J Mol Biol. 2023 Nov 05; 168354. Jang H, Chen J, Iakoucheva LM, Nussinov R. PMID: 37935253.
      View in: PubMed   Mentions:    Fields:    
    2. Correction to: Therapeutic strategies for autism: targeting three levels of the central dogma of molecular biology. Transl Psychiatry. 2023 Mar 07; 13(1):80. Hong D, Iakoucheva LM. PMID: 36882413; PMCID: PMC9992495.
      View in: PubMed   Mentions:    Fields:    
    3. Therapeutic strategies for autism: targeting three levels of the central dogma of molecular biology. Transl Psychiatry. 2023 02 16; 13(1):58. Hong D, Iakoucheva LM. PMID: 36792602; PMCID: PMC9931756.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Author Correction: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2023 Feb 02; 14(1):569. Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Wanamaker SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM. PMID: 36732511; PMCID: PMC9895433.
      View in: PubMed   Mentions:    Fields:    
    5. How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain. bioRxiv. 2023 Jan 27. Jang H, Chen J, Iakoucheva LM, Nussinov R. PMID: 36747841; PMCID: PMC9900933.
      View in: PubMed   Mentions:
    6. Multi-objective prioritization of genes for high-throughput functional assays towards improved clinical variant classification. Pac Symp Biocomput. 2023; 28:323-334. Chen Y, Jain S, Zeiberg D, Iakoucheva LM, Mooney SD, Radivojac P, Pejaver V. PMID: 36540988; PMCID: PMC10042589.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nat Genet. 2022 Aug; 54(8):1259. Antaki D, Guevara J, Maihofer AX, Klein M, Gujral M, Grove J, Carey CE, Hong O, Arranz MJ, Hervas A, Corsello C, Vaux KK, Muotri AR, Iakoucheva LM, Courchesne E, Pierce K, Gleeson JG, Robinson EB, Nievergelt CM, Sebat J. PMID: 35768728.
      View in: PubMed   Mentions: 2     Fields:    
    8. A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nat Genet. 2022 09; 54(9):1284-1292. Antaki D, Guevara J, Maihofer AX, Klein M, Gujral M, Grove J, Carey CE, Hong O, Arranz MJ, Hervas A, Corsello C, Vaux KK, Muotri AR, Iakoucheva LM, Courchesne E, Pierce K, Gleeson JG, Robinson EB, Nievergelt CM, Sebat J. PMID: 35654974; PMCID: PMC9474668.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    9. Correction: Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry. 2021 Dec; 26(12):7581. Urresti J, Zhang P, Moran-Losada P, Yu NK, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates Iii JR, Muotri AR, Iakoucheva LM. PMID: 34548630; PMCID: PMC9119232.
      View in: PubMed   Mentions: 5     Fields:    
    10. Prioritizing de novo autism risk variants with calibrated gene- and variant-scoring models. Hum Genet. 2022 Oct; 141(10):1595-1613. Jiang Y, Urresti J, Pagel KA, Pramod AB, Iakoucheva LM, Radivojac P. PMID: 34549350; PMCID: PMC8938308.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Full-length isoform transcriptome of the developing human brain provides further insights into autism. Cell Rep. 2021 08 31; 36(9):109631. Chau KK, Zhang P, Urresti J, Amar M, Pramod AB, Chen J, Thomas A, Corominas R, Lin GN, Iakoucheva LM. PMID: 34469739; PMCID: PMC8437376.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry. 2021 12; 26(12):7560-7580. Urresti J, Zhang P, Moran-Losada P, Yu NK, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates Iii JR, Muotri AR, Iakoucheva LM. PMID: 34433918; PMCID: PMC8873019.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    13. Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling. Mol Psychiatry. 2021 07; 26(7):3586-3613. Amar M, Pramod AB, Yu NK, Herrera VM, Qiu LR, Moran-Losada P, Zhang P, Trujillo CA, Ellegood J, Urresti J, Chau K, Diedrich J, Chen J, Gutierrez J, Sebat J, Ramanathan D, Lerch JP, Yates JR, Muotri AR, Iakoucheva LM. PMID: 33727673; PMCID: PMC8443683.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    14. Inferring the molecular and phenotypic impact of amino acid variants with MutPred2. Nat Commun. 2020 11 20; 11(1):5918. Pejaver V, Urresti J, Lugo-Martinez J, Pagel KA, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 33219223; PMCID: PMC7680112.
      View in: PubMed   Mentions: 174     Fields:    Translation:Humans
    15. Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development. Cell Rep. 2019 09 24; 28(13):3320-3328.e4. Qiu Y, Arbogast T, Lorenzo SM, Li H, Tang SC, Richardson E, Hong O, Cho S, Shanta O, Pang T, Corsello C, Deutsch CK, Chevalier C, Davis EE, Iakoucheva LM, Herault Y, Katsanis N, Messer K, Sebat J. PMID: 31553903; PMCID: PMC6988705.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    16. Getting to the Cores of Autism. Cell. 2019 09 05; 178(6):1287-1298. Iakoucheva LM, Muotri AR, Sebat J. PMID: 31491383; PMCID: PMC7039308.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    17. Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome. PLoS Comput Biol. 2019 06; 15(6):e1007112. Pagel KA, Antaki D, Lian A, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 31199787; PMCID: PMC6594643.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    18. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018 12 14; 362(6420). Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE, PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH. PMID: 30545856; PMCID: PMC6443102.
      View in: PubMed   Mentions: 410     Fields:    Translation:HumansCells
    19. Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 04 20; 360(6386):327-331. Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. PMID: 29674594; PMCID: PMC6449150.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    20. When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants. Bioinformatics. 2017 Jul 15; 33(14):i389-i398. Pagel KA, Pejaver V, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 28882004; PMCID: PMC5870554.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    21. Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases. Methods Mol Biol. 2017; 1613:371-402. Lin GN, Corominas R, Nam HJ, Urresti J, Iakoucheva LM. PMID: 28849569; PMCID: PMC5699888.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 07; 98(4):667-79. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. PMID: 27018473; PMCID: PMC4833290.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    23. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 02 11; 164(4):805-17. Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Wanamaker SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M. PMID: 26871637; PMCID: PMC4882190.
      View in: PubMed   Mentions: 248     Fields:    Translation:HumansAnimalsCells
    24. Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases. Neuron. 2015 Feb 18; 85(4):742-54. Lin GN, Corominas R, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM. PMID: 25695269; PMCID: PMC4335356.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    25. A proteome-scale map of the human interactome network. Cell. 2014 11 20; 159(5):1212-1226. Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Wanamaker SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M. PMID: 25416956; PMCID: PMC4266588.
      View in: PubMed   Mentions: 610     Fields:    Translation:HumansAnimals
    26. Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev. 2014 Jul 09; 114(13):6844-79. Uversky VN, Davé V, Iakoucheva LM, Malaney P, Metallo SJ, Pathak RR, Joerger AC. PMID: 24830552; PMCID: PMC4100540.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    27. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2014 Apr 11; 5:3650. Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Wanamaker SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM. PMID: 24722188; PMCID: PMC3996537.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    28. Predicted disorder-to-order transition mutations in IκBα disrupt function. Phys Chem Chem Phys. 2014 Apr 14; 16(14):6480-5. Dembinski H, Wismer K, Balasubramaniam D, Gonzalez HA, Alverdi V, Iakoucheva LM, Komives EA. PMID: 24605363; PMCID: PMC4040282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell. 2012 Dec 21; 151(7):1431-42. Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, Corominas R, Peoples A, Koren A, Gore A, Kang S, Lin GN, Estabillo J, Gadomski T, Singh B, Zhang K, Akshoomoff N, Corsello C, McCarroll S, Iakoucheva LM, Li Y, Wang J, Sebat J. PMID: 23260136; PMCID: PMC3712641.
      View in: PubMed   Mentions: 282     Fields:    Translation:HumansAnimalsCells
    30. Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder. PLoS Comput Biol. 2012; 8(10):e1002709. Vacic V, Markwick PR, Oldfield CJ, Zhao X, Haynes C, Uversky VN, Iakoucheva LM. PMID: 23055912; PMCID: PMC3464192.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    31. Disease mutations in disordered regions--exception to the rule? Mol Biosyst. 2012 Jan; 8(1):27-32. Vacic V, Iakoucheva LM. PMID: 22080206; PMCID: PMC3307532.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    32. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 2011 Mar 24; 471(7339):499-503. Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, Craig D, Kelsoe JR, Gershon ES, Leal SM, Dell Aquila M, Morris DW, Gill M, Corvin A, Insel PA, McClellan J, King MC, Karayiorgou M, Levy DL, DeLisi LE, Sebat J. PMID: 21346763; PMCID: PMC3351382.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansCells
    33. Mapping copy number variation by population-scale genome sequencing. Nature. 2011 Feb 03; 470(7332):59-65. Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HY, Leng J, Li R, Li Y, Lin CY, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, Stütz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE, Gerstein MB, Hurles ME, Lee C, McCarroll SA, Korbel JO, 1000 Genomes Project. PMID: 21293372; PMCID: PMC3077050.
      View in: PubMed   Mentions: 600     Fields:    Translation:Humans
    34. Identification, analysis, and prediction of protein ubiquitination sites. Proteins. 2010 Feb 01; 78(2):365-80. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. PMID: 19722269; PMCID: PMC3006176.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    35. Graphlet kernels for prediction of functional residues in protein structures. J Comput Biol. 2010 Jan; 17(1):55-72. Vacic V, Iakoucheva LM, Lonardi S, Radivojac P. PMID: 20078397; PMCID: PMC2921594.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    36. Loss of post-translational modification sites in disease. Pac Symp Biocomput. 2010; 337-47. Li S, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 19908386; PMCID: PMC2813771.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    37. Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet. 2009 Nov; 41(11):1223-7. McCarthy SE, Makarov V, Kirov G, Addington AM, McClellan J, Yoon S, Perkins DO, Dickel DE, Kusenda M, Krastoshevsky O, Krause V, Kumar RA, Grozeva D, Malhotra D, Walsh T, Zackai EH, Kaplan P, Ganesh J, Krantz ID, Spinner NB, Roccanova P, Bhandari A, Pavon K, Lakshmi B, Leotta A, Kendall J, Lee YH, Vacic V, Gary S, Iakoucheva LM, Crow TJ, Christian SL, Lieberman JA, Stroup TS, Lehtimäki T, Puura K, Haldeman-Englert C, Pearl J, Goodell M, Willour VL, Derosse P, Steele J, Kassem L, Wolff J, Chitkara N, McMahon FJ, Malhotra AK, Potash JB, Schulze TG, Nöthen MM, Cichon S, Rietschel M, Leibenluft E, Kustanovich V, Lajonchere CM, Sutcliffe JS, Skuse D, Gill M, Gallagher L, Mendell NR, Wellcome Trust Case Control Consortium, Craddock N, Owen MJ, O'Donovan MC, Shaikh TH, Susser E, Delisi LE, Sullivan PF, Deutsch CK, Rapoport J, Levy DL, King MC, Sebat J. PMID: 19855392; PMCID: PMC2951180.
      View in: PubMed   Mentions: 340     Fields:    Translation:HumansCells
    38. Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics. 2009 Jul 07; 10 Suppl 1:S7. Uversky VN, Oldfield CJ, Midic U, Xie H, Xue B, Vucetic S, Iakoucheva LM, Obradovic Z, Dunker AK. PMID: 19594884; PMCID: PMC2709268.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    39. A protein domain-based interactome network for C. elegans early embryogenesis. Cell. 2008 Aug 08; 134(3):534-45. Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, de Lichtervelde L, Mul JD, van de Peut D, Devos M, Simonis N, Yildirim MA, Cokol M, Kao HL, de Smet AS, Wang H, Schlaitz AL, Hao T, Milstein S, Fan C, Tipsword M, Drew K, Galli M, Rhrissorrakrai K, Drechsel D, Koller D, Roth FP, Iakoucheva LM, Dunker AK, Bonneau R, Gunsalus KC, Hill DE, Piano F, Tavernier J, van den Heuvel S, Hyman AA, Vidal M. PMID: 18692475; PMCID: PMC2596478.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    40. Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics. 2008; 9 Suppl 1:S1. Oldfield CJ, Meng J, Yang JY, Yang MQ, Uversky VN, Dunker AK. PMID: 18366598; PMCID: PMC2386051.
      View in: PubMed   Mentions: 257     Fields:    Translation:Cells
    41. RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins. Biochim Biophys Acta. 2008 Feb; 1780(2):214-25. Nikolakaki E, Drosou V, Sanidas I, Peidis P, Papamarcaki T, Iakoucheva LM, Giannakouros T. PMID: 18022399.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    42. Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res. 2007 May; 6(5):1917-32. Xie H, Vucetic S, Iakoucheva LM, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN. PMID: 17391016; PMCID: PMC2588348.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    43. Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res. 2007 May; 6(5):1882-98. Xie H, Vucetic S, Iakoucheva LM, Oldfield CJ, Dunker AK, Uversky VN, Obradovic Z. PMID: 17391014; PMCID: PMC2543138.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansAnimalsCells
    44. Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res. 2007 May; 6(5):1899-916. Vucetic S, Xie H, Iakoucheva LM, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN. PMID: 17391015; PMCID: PMC2588346.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    45. Prediction of intrinsic disorder and its use in functional proteomics. Methods Mol Biol. 2007; 408:69-92. Uversky VN, Radivojac P, Iakoucheva LM, Obradovic Z, Dunker AK. PMID: 18314578.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    46. Intrinsic disorder and functional proteomics. Biophys J. 2007 Mar 01; 92(5):1439-56. Radivojac P, Iakoucheva LM, Oldfield CJ, Obradovic Z, Uversky VN, Dunker AK. PMID: 17158572; PMCID: PMC1796814.
      View in: PubMed   Mentions: 300     Fields:    Translation:HumansAnimalsCells
    47. Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol. 2006 Aug 04; 2(8):e100. Haynes C, Oldfield CJ, Ji F, Klitgord N, Cusick ME, Radivojac P, Uversky VN, Vidal M, Iakoucheva LM. PMID: 16884331; PMCID: PMC1526461.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    48. Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments. Bioinformatics. 2006 Jun 15; 22(12):1536-7. Vacic V, Iakoucheva LM, Radivojac P. PMID: 16632492.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansCells
    49. Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Res. 2006; 34(1):305-12. Haynes C, Iakoucheva LM. PMID: 16407336; PMCID: PMC1326245.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    50. Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J. 2005 Oct; 272(20):5129-48. Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN. PMID: 16218947.
      View in: PubMed   Mentions: 501     Fields:    Translation:HumansAnimalsCells
    51. Combining prediction, computation and experiment for the characterization of protein disorder. Curr Opin Struct Biol. 2004 Oct; 14(5):570-6. Bracken C, Iakoucheva LM, Romero PR, Dunker AK. PMID: 15465317.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    52. DisProt: a database of protein disorder. Bioinformatics. 2005 Jan 01; 21(1):137-40. Vucetic S, Obradovic Z, Vacic V, Radivojac P, Peng K, Iakoucheva LM, Cortese MS, Lawson JD, Brown CJ, Sikes JG, Newton CD, Dunker AK. PMID: 15310560.
      View in: PubMed   Mentions: 89     Fields:    Translation:Cells
    53. The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res. 2004; 32(3):1037-49. Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes JG, Obradovic Z, Dunker AK. PMID: 14960716; PMCID: PMC373391.
      View in: PubMed   Mentions: 639     Fields:    Translation:AnimalsCells
    54. Order, disorder, and flexibility: prediction from protein sequence. Structure. 2003 Nov; 11(11):1316-7. Iakoucheva LM, Dunker AK. PMID: 14604521.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    55. Intrinsic disorder in cell-signaling and cancer-associated proteins. J Mol Biol. 2002 Oct 25; 323(3):573-84. Iakoucheva LM, Brown CJ, Lawson JD, Obradovic Z, Dunker AK. PMID: 12381310.
      View in: PubMed   Mentions: 488     Fields:    Translation:HumansCells
    56. Intrinsic disorder and protein function. Biochemistry. 2002 May 28; 41(21):6573-82. Dunker AK, Brown CJ, Lawson JD, Iakoucheva LM, Obradovic Z. PMID: 12022860.
      View in: PubMed   Mentions: 686     Fields:    Translation:Cells
    57. Equilibrium and stop-flow kinetic studies of fluorescently labeled DNA substrates with DNA repair proteins XPA and replication protein A. Biochemistry. 2002 Jan 08; 41(1):131-43. Iakoucheva LM, Walker RK, van Houten B, Ackerman EJ. PMID: 11772010.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    58. Single-molecule conformational dynamics of fluctuating noncovalent DNA-protein interactions in DNA damage recognition. J Am Chem Soc. 2001 Sep 19; 123(37):9184-5. Lu HP, Iakoucheva LM, Ackerman EJ. PMID: 11552836.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    59. Aberrant mobility phenomena of the DNA repair protein XPA. Protein Sci. 2001 Jul; 10(7):1353-62. Iakoucheva LM, Kimzey AL, Masselon CD, Smith RD, Dunker AK, Ackerman EJ. PMID: 11420437; PMCID: PMC2374115.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    60. Identification of intrinsic order and disorder in the DNA repair protein XPA. Protein Sci. 2001 Mar; 10(3):560-71. Iakoucheva LM, Kimzey AL, Masselon CD, Bruce JE, Garner EC, Brown CJ, Dunker AK, Smith RD, Ackerman EJ. PMID: 11344324; PMCID: PMC2374143.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    61. Nucleotide excision repair in oocyte nuclear extracts from Xenopus laevis. Methods. 2000 Oct; 22(2):188-93. Ackerman EJ, Iakoucheva LM. PMID: 11020334.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    62. Extended X-ray absorption fine structure evidence for a single metal binding domain in Xenopus laevis nucleotide excision repair protein XPA. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):109-13. Buchko GW, Iakoucheva LM, Kennedy MA, Ackerman EJ, Hess NJ. PMID: 9920741.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    With one click, see people who:

    Mentor Faculty

    Run Clinical Trials

    See more options in the Advanced Search tab

    Lilia's Networks
    Concepts (264)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (28)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-2-gbbe5f151 on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California