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Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain. J Mol Biol. 2023 12 15; 435(24):168354.
Jang H, Chen J, Iakoucheva LM, Nussinov R. PMID: 37935253; PMCID: PMC10842829.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Correction to: Therapeutic strategies for autism: targeting three levels of the central dogma of molecular biology. Transl Psychiatry. 2023 Mar 07; 13(1):80.
Hong D, Iakoucheva LM. PMID: 36882413; PMCID: PMC9992495.
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PubMed Mentions: Fields:
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Therapeutic strategies for autism: targeting three levels of the central dogma of molecular biology. Transl Psychiatry. 2023 02 16; 13(1):58.
Hong D, Iakoucheva LM. PMID: 36792602; PMCID: PMC9931756.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Author Correction: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2023 Feb 02; 14(1):569.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Wanamaker SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM. PMID: 36732511; PMCID: PMC9895433.
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PubMed Mentions: Fields:
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How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain. bioRxiv. 2023 Jan 27.
Jang H, Chen J, Iakoucheva LM, Nussinov R. PMID: 36747841; PMCID: PMC9900933.
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Multi-objective prioritization of genes for high-throughput functional assays towards improved clinical variant classification. Pac Symp Biocomput. 2023; 28:323-334.
Chen Y, Jain S, Zeiberg D, Iakoucheva LM, Mooney SD, Radivojac P, Pejaver V. PMID: 36540988; PMCID: PMC10042589.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nat Genet. 2022 Aug; 54(8):1259.
Antaki D, Guevara J, Maihofer AX, Klein M, Gujral M, Grove J, Carey CE, Hong O, Arranz MJ, Hervas A, Corsello C, Vaux KK, Muotri AR, Iakoucheva LM, Courchesne E, Pierce K, Gleeson JG, Robinson EB, Nievergelt CM, Sebat J. PMID: 35768728.
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PubMed Mentions:
3 Fields:
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A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nat Genet. 2022 09; 54(9):1284-1292.
Antaki D, Guevara J, Maihofer AX, Klein M, Gujral M, Grove J, Carey CE, Hong O, Arranz MJ, Hervas A, Corsello C, Vaux KK, Muotri AR, Iakoucheva LM, Courchesne E, Pierce K, Gleeson JG, Robinson EB, Nievergelt CM, Sebat J. PMID: 35654974; PMCID: PMC9474668.
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PubMed Mentions:
74 Fields:
Translation:
Humans
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Correction: Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry. 2021 Dec; 26(12):7581.
Urresti J, Zhang P, Moran-Losada P, Yu NK, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates Iii JR, Muotri AR, Iakoucheva LM. PMID: 34548630; PMCID: PMC9119232.
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PubMed Mentions:
3 Fields:
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Prioritizing de novo autism risk variants with calibrated gene- and variant-scoring models. Hum Genet. 2022 Oct; 141(10):1595-1613.
Jiang Y, Urresti J, Pagel KA, Pramod AB, Iakoucheva LM, Radivojac P. PMID: 34549350; PMCID: PMC8938308.
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Humans
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Full-length isoform transcriptome of the developing human brain provides further insights into autism. Cell Rep. 2021 08 31; 36(9):109631.
Chau KK, Zhang P, Urresti J, Amar M, Pramod AB, Chen J, Thomas A, Corominas R, Lin GN, Iakoucheva LM. PMID: 34469739; PMCID: PMC8437376.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry. 2021 12; 26(12):7560-7580.
Urresti J, Zhang P, Moran-Losada P, Yu NK, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates Iii JR, Muotri AR, Iakoucheva LM. PMID: 34433918; PMCID: PMC8873019.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling. Mol Psychiatry. 2021 07; 26(7):3586-3613.
Amar M, Pramod AB, Yu NK, Herrera VM, Qiu LR, Moran-Losada P, Zhang P, Trujillo CA, Ellegood J, Urresti J, Chau K, Diedrich J, Chen J, Gutierrez J, Sebat J, Ramanathan D, Lerch JP, Yates JR, Muotri AR, Iakoucheva LM. PMID: 33727673; PMCID: PMC8443683.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Inferring the molecular and phenotypic impact of amino acid variants with MutPred2. Nat Commun. 2020 11 20; 11(1):5918.
Pejaver V, Urresti J, Lugo-Martinez J, Pagel KA, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 33219223; PMCID: PMC7680112.
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PubMed Mentions:
328 Fields:
Translation:
Humans
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Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development. Cell Rep. 2019 09 24; 28(13):3320-3328.e4.
Qiu Y, Arbogast T, Lorenzo SM, Li H, Tang SC, Richardson E, Hong O, Cho S, Shanta O, Pang T, Corsello C, Deutsch CK, Chevalier C, Davis EE, Iakoucheva LM, Herault Y, Katsanis N, Messer K, Sebat J. PMID: 31553903; PMCID: PMC6988705.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Getting to the Cores of Autism. Cell. 2019 09 05; 178(6):1287-1298.
Iakoucheva LM, Muotri AR, Sebat J. PMID: 31491383; PMCID: PMC7039308.
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PubMed Mentions:
120 Fields:
Translation:
HumansAnimalsCells
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Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome. PLoS Comput Biol. 2019 06; 15(6):e1007112.
Pagel KA, Antaki D, Lian A, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 31199787; PMCID: PMC6594643.
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PubMed Mentions:
29 Fields:
Translation:
Humans
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Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018 12 14; 362(6420).
Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE, PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH. PMID: 30545856; PMCID: PMC6443102.
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PubMed Mentions:
527 Fields:
Translation:
HumansCells
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Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 04 20; 360(6386):327-331.
Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. PMID: 29674594; PMCID: PMC6449150.
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PubMed Mentions:
102 Fields:
Translation:
HumansCells
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When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants. Bioinformatics. 2017 Jul 15; 33(14):i389-i398.
Pagel KA, Pejaver V, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 28882004; PMCID: PMC5870554.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases. Methods Mol Biol. 2017; 1613:371-402.
Lin GN, Corominas R, Nam HJ, Urresti J, Iakoucheva LM. PMID: 28849569; PMCID: PMC5699888.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 07; 98(4):667-79.
Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. PMID: 27018473; PMCID: PMC4833290.
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PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 02 11; 164(4):805-17.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Wanamaker SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M. PMID: 26871637; PMCID: PMC4882190.
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PubMed Mentions:
278 Fields:
Translation:
HumansAnimalsCells
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Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases. Neuron. 2015 Feb 18; 85(4):742-54.
Lin GN, Corominas R, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM. PMID: 25695269; PMCID: PMC4335356.
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PubMed Mentions:
98 Fields:
Translation:
HumansCells
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A proteome-scale map of the human interactome network. Cell. 2014 11 20; 159(5):1212-1226.
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Wanamaker SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M. PMID: 25416956; PMCID: PMC4266588.
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PubMed Mentions:
669 Fields:
Translation:
HumansAnimals
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Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev. 2014 Jul 09; 114(13):6844-79.
Uversky VN, Davé V, Iakoucheva LM, Malaney P, Metallo SJ, Pathak RR, Joerger AC. PMID: 24830552; PMCID: PMC4100540.
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PubMed Mentions:
108 Fields:
Translation:
HumansCells
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Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2014 Apr 11; 5:3650.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Wanamaker SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM. PMID: 24722188; PMCID: PMC3996537.
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PubMed Mentions:
76 Fields:
Translation:
HumansCells
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Predicted disorder-to-order transition mutations in IκBα disrupt function. Phys Chem Chem Phys. 2014 Apr 14; 16(14):6480-5.
Dembinski H, Wismer K, Balasubramaniam D, Gonzalez HA, Alverdi V, Iakoucheva LM, Komives EA. PMID: 24605363; PMCID: PMC4040282.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell. 2012 Dec 21; 151(7):1431-42.
Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, Corominas R, Peoples A, Koren A, Gore A, Kang S, Lin GN, Estabillo J, Gadomski T, Singh B, Zhang K, Akshoomoff N, Corsello C, McCarroll S, Iakoucheva LM, Li Y, Wang J, Sebat J. PMID: 23260136; PMCID: PMC3712641.
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PubMed Mentions:
305 Fields:
Translation:
HumansAnimalsCells
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Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder. PLoS Comput Biol. 2012; 8(10):e1002709.
Vacic V, Markwick PR, Oldfield CJ, Zhao X, Haynes C, Uversky VN, Iakoucheva LM. PMID: 23055912; PMCID: PMC3464192.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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Disease mutations in disordered regions--exception to the rule? Mol Biosyst. 2012 Jan; 8(1):27-32.
Vacic V, Iakoucheva LM. PMID: 22080206; PMCID: PMC3307532.
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PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
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Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 2011 Mar 24; 471(7339):499-503.
Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, Craig D, Kelsoe JR, Gershon ES, Leal SM, Dell Aquila M, Morris DW, Gill M, Corvin A, Insel PA, McClellan J, King MC, Karayiorgou M, Levy DL, DeLisi LE, Sebat J. PMID: 21346763; PMCID: PMC3351382.
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PubMed Mentions:
159 Fields:
Translation:
HumansCells
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Mapping copy number variation by population-scale genome sequencing. Nature. 2011 Feb 03; 470(7332):59-65.
Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HY, Leng J, Li R, Li Y, Lin CY, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, Stütz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE, Gerstein MB, Hurles ME, Lee C, McCarroll SA, Korbel JO, 1000 Genomes Project. PMID: 21293372; PMCID: PMC3077050.
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PubMed Mentions:
622 Fields:
Translation:
Humans
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Identification, analysis, and prediction of protein ubiquitination sites. Proteins. 2010 Feb 01; 78(2):365-80.
Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. PMID: 19722269; PMCID: PMC3006176.
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PubMed Mentions:
263 Fields:
Translation:
HumansAnimalsCells
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Graphlet kernels for prediction of functional residues in protein structures. J Comput Biol. 2010 Jan; 17(1):55-72.
Vacic V, Iakoucheva LM, Lonardi S, Radivojac P. PMID: 20078397; PMCID: PMC2921594.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Loss of post-translational modification sites in disease. Pac Symp Biocomput. 2010; 337-47.
Li S, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 19908386; PMCID: PMC2813771.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet. 2009 Nov; 41(11):1223-7.
McCarthy SE, Makarov V, Kirov G, Addington AM, McClellan J, Yoon S, Perkins DO, Dickel DE, Kusenda M, Krastoshevsky O, Krause V, Kumar RA, Grozeva D, Malhotra D, Walsh T, Zackai EH, Kaplan P, Ganesh J, Krantz ID, Spinner NB, Roccanova P, Bhandari A, Pavon K, Lakshmi B, Leotta A, Kendall J, Lee YH, Vacic V, Gary S, Iakoucheva LM, Crow TJ, Christian SL, Lieberman JA, Stroup TS, Lehtimäki T, Puura K, Haldeman-Englert C, Pearl J, Goodell M, Willour VL, Derosse P, Steele J, Kassem L, Wolff J, Chitkara N, McMahon FJ, Malhotra AK, Potash JB, Schulze TG, Nöthen MM, Cichon S, Rietschel M, Leibenluft E, Kustanovich V, Lajonchere CM, Sutcliffe JS, Skuse D, Gill M, Gallagher L, Mendell NR, Wellcome Trust Case Control Consortium, Craddock N, Owen MJ, O'Donovan MC, Shaikh TH, Susser E, Delisi LE, Sullivan PF, Deutsch CK, Rapoport J, Levy DL, King MC, Sebat J. PMID: 19855392; PMCID: PMC2951180.
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PubMed Mentions:
344 Fields:
Translation:
HumansCells
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Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics. 2009 Jul 07; 10 Suppl 1:S7.
Uversky VN, Oldfield CJ, Midic U, Xie H, Xue B, Vucetic S, Iakoucheva LM, Obradovic Z, Dunker AK. PMID: 19594884; PMCID: PMC2709268.
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PubMed Mentions:
105 Fields:
Translation:
HumansCells
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A protein domain-based interactome network for C. elegans early embryogenesis. Cell. 2008 Aug 08; 134(3):534-45.
Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, de Lichtervelde L, Mul JD, van de Peut D, Devos M, Simonis N, Yildirim MA, Cokol M, Kao HL, de Smet AS, Wang H, Schlaitz AL, Hao T, Milstein S, Fan C, Tipsword M, Drew K, Galli M, Rhrissorrakrai K, Drechsel D, Koller D, Roth FP, Iakoucheva LM, Dunker AK, Bonneau R, Gunsalus KC, Hill DE, Piano F, Tavernier J, van den Heuvel S, Hyman AA, Vidal M. PMID: 18692475; PMCID: PMC2596478.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics. 2008; 9 Suppl 1:S1.
Oldfield CJ, Meng J, Yang JY, Yang MQ, Uversky VN, Dunker AK. PMID: 18366598; PMCID: PMC2386051.
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PubMed Mentions:
269 Fields:
Translation:
Cells
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RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins. Biochim Biophys Acta. 2008 Feb; 1780(2):214-25.
Nikolakaki E, Drosou V, Sanidas I, Peidis P, Papamarcaki T, Iakoucheva LM, Giannakouros T. PMID: 18022399.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res. 2007 May; 6(5):1917-32.
Xie H, Vucetic S, Iakoucheva LM, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN. PMID: 17391016; PMCID: PMC2588348.
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PubMed Mentions:
170 Fields:
Translation:
HumansAnimalsCells
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Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res. 2007 May; 6(5):1882-98.
Xie H, Vucetic S, Iakoucheva LM, Oldfield CJ, Dunker AK, Uversky VN, Obradovic Z. PMID: 17391014; PMCID: PMC2543138.
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PubMed Mentions:
235 Fields:
Translation:
HumansAnimalsCells
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Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res. 2007 May; 6(5):1899-916.
Vucetic S, Xie H, Iakoucheva LM, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN. PMID: 17391015; PMCID: PMC2588346.
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PubMed Mentions:
107 Fields:
Translation:
HumansAnimalsCells
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Prediction of intrinsic disorder and its use in functional proteomics. Methods Mol Biol. 2007; 408:69-92.
Uversky VN, Radivojac P, Iakoucheva LM, Obradovic Z, Dunker AK. PMID: 18314578.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Intrinsic disorder and functional proteomics. Biophys J. 2007 Mar 01; 92(5):1439-56.
Radivojac P, Iakoucheva LM, Oldfield CJ, Obradovic Z, Uversky VN, Dunker AK. PMID: 17158572; PMCID: PMC1796814.
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PubMed Mentions:
302 Fields:
Translation:
HumansAnimalsCells
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Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol. 2006 Aug 04; 2(8):e100.
Haynes C, Oldfield CJ, Ji F, Klitgord N, Cusick ME, Radivojac P, Uversky VN, Vidal M, Iakoucheva LM. PMID: 16884331; PMCID: PMC1526461.
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PubMed Mentions:
259 Fields:
Translation:
HumansAnimalsCells
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Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments. Bioinformatics. 2006 Jun 15; 22(12):1536-7.
Vacic V, Iakoucheva LM, Radivojac P. PMID: 16632492.
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PubMed Mentions:
222 Fields:
Translation:
HumansCells
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Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Res. 2006; 34(1):305-12.
Haynes C, Iakoucheva LM. PMID: 16407336; PMCID: PMC1326245.
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PubMed Mentions:
62 Fields:
Translation:
HumansCells
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Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J. 2005 Oct; 272(20):5129-48.
Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN. PMID: 16218947.
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PubMed Mentions:
508 Fields:
Translation:
HumansAnimalsCells
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Combining prediction, computation and experiment for the characterization of protein disorder. Curr Opin Struct Biol. 2004 Oct; 14(5):570-6.
Bracken C, Iakoucheva LM, Romero PR, Dunker AK. PMID: 15465317.
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PubMed Mentions:
37 Fields:
Translation:
Cells
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DisProt: a database of protein disorder. Bioinformatics. 2005 Jan 01; 21(1):137-40.
Vucetic S, Obradovic Z, Vacic V, Radivojac P, Peng K, Iakoucheva LM, Cortese MS, Lawson JD, Brown CJ, Sikes JG, Newton CD, Dunker AK. PMID: 15310560.
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PubMed Mentions:
87 Fields:
Translation:
Cells
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The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res. 2004; 32(3):1037-49.
Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes JG, Obradovic Z, Dunker AK. PMID: 14960716; PMCID: PMC373391.
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PubMed Mentions:
658 Fields:
Translation:
AnimalsCells
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Order, disorder, and flexibility: prediction from protein sequence. Structure. 2003 Nov; 11(11):1316-7.
Iakoucheva LM, Dunker AK. PMID: 14604521.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Intrinsic disorder in cell-signaling and cancer-associated proteins. J Mol Biol. 2002 Oct 25; 323(3):573-84.
Iakoucheva LM, Brown CJ, Lawson JD, Obradovic Z, Dunker AK. PMID: 12381310.
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PubMed Mentions:
511 Fields:
Translation:
HumansCells
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Intrinsic disorder and protein function. Biochemistry. 2002 May 28; 41(21):6573-82.
Dunker AK, Brown CJ, Lawson JD, Iakoucheva LM, Obradovic Z. PMID: 12022860.
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PubMed Mentions:
681 Fields:
Translation:
Cells
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Equilibrium and stop-flow kinetic studies of fluorescently labeled DNA substrates with DNA repair proteins XPA and replication protein A. Biochemistry. 2002 Jan 08; 41(1):131-43.
Iakoucheva LM, Walker RK, van Houten B, Ackerman EJ. PMID: 11772010.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Single-molecule conformational dynamics of fluctuating noncovalent DNA-protein interactions in DNA damage recognition. J Am Chem Soc. 2001 Sep 19; 123(37):9184-5.
Lu HP, Iakoucheva LM, Ackerman EJ. PMID: 11552836.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Aberrant mobility phenomena of the DNA repair protein XPA. Protein Sci. 2001 Jul; 10(7):1353-62.
Iakoucheva LM, Kimzey AL, Masselon CD, Smith RD, Dunker AK, Ackerman EJ. PMID: 11420437; PMCID: PMC2374115.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Identification of intrinsic order and disorder in the DNA repair protein XPA. Protein Sci. 2001 Mar; 10(3):560-71.
Iakoucheva LM, Kimzey AL, Masselon CD, Bruce JE, Garner EC, Brown CJ, Dunker AK, Smith RD, Ackerman EJ. PMID: 11344324; PMCID: PMC2374143.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Nucleotide excision repair in oocyte nuclear extracts from Xenopus laevis. Methods. 2000 Oct; 22(2):188-93.
Ackerman EJ, Iakoucheva LM. PMID: 11020334.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Extended X-ray absorption fine structure evidence for a single metal binding domain in Xenopus laevis nucleotide excision repair protein XPA. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):109-13.
Buchko GW, Iakoucheva LM, Kennedy MA, Ackerman EJ, Hess NJ. PMID: 9920741.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells