Lilia Iakoucheva

Title(s)Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-4542-5219 Additional info
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    Biography

    Dr. Lilia Iakoucheva obtained B.S. in genetics from Kiev State University (Kiev, Ukraine) and Ph.D. in molecular biology and immunology from the Institute of Immunology (Moscow, Russia). After completing postdoctoral training in protein biochemistry at the Pacific Northwest National Laboratory (Richland, WA) she joined the group of Prof. Keith Dunker to study intrinsically disordered proteins. During that time and with active Dr. Iakoucheva’s participation, the group made a series of fundamental discoveries about disordered proteins, including their role in cell signaling and cancer, the importance of disorder for post-translational modifications and for interactions with other proteins and ligands. In 2003, Dr. Iakoucheva joined the Rockefeller University (New York, NY) as a Research Assistant Professor, where she continued to investigate functional properties of disordered proteins, at the same time gradually shifting her interests into disease-oriented field. Rapid advancement in the disease gene discovery in the post-genomic era opened new avenues and opportunities for more detailed investigation of protein interaction networks and pathways underlying many human diseases. Dr. Iakoucheva became especially interested in the molecular basis of psychiatric diseases, which she began to explore using systems biology approaches. She joined the Psychiatry Department of the University of California San Diego (La Jolla, CA) as an Assistant Professor in 2010, where she continues to apply her experience in protein structure, disorder and protein-protein interactions analyses towards investigation of autism and schizophrenia. Dr. Iakoucheva has been the principal investigator on research grants from NSF, NCI, NICHD, and NIMH.

    Research Interests

    Dr. Iakoucheva’s research focuses on understanding of the molecular basis of autism and schizophrenia using systems biology approaches. Our aim is to discover functional protein interaction networks connecting seemingly unrelated candidate genes for psychiatric diseases. We are building comprehensive protein-protein interaction networks for autism and schizophrenia candidate genes and their splicing isoforms. In addition, we are integrating gene expression data with our experimentally derived networks to understand spatio-temporal dynamics of protein interactions in the brain. Our immediate goal is to investigate perturbations of the disease networks by the Copy Number Variants (CNVs) and protein-damaging Single Nucleotide Variants (SNVs) identified in the patients using the Whole Exome Sequencing (WES) studies. Additionally, we are interested in interpreting non-coding genetic variation with relevance to psychiatric diseases. We are investigating functional impact of UTR, promoter and splice site mutations identified in the Whole Genome Sequencing (WGS) studies of autism and schizophrenia using in vitro cellular systems.

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    Collapse Research Activities and Funding
    Effects of acetaminophen on prenatal brain development: an organoid model
    NIH R21HD109616Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigat
    Rescue of Cul3 haploinsufficiency phenotypes with CRISPR-mediated Cul3 activation
    NIH R21MH128827Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigator
    Cortical organoid models to study autism-associated 16p.11.2.CNV
    NIH R56MH128365Mar 1, 2022 - Feb 28, 2023
    Role: Principal Investigator
    Investigating neurodevelopmental toxicity of perfluoroalkyl acids and their derivatives in human brain organoids models
    NIH R01ES033636Feb 7, 2022 - Nov 30, 2026
    Role: Principal Investigator
    Integrative functional genomic study of pathways impacted by recurrent autism CNV
    NIH R01MH108528Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Evaluating the effect of splicing mutations on isoform networks in autism
    NIH R01MH109885May 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    A computational framework for predicting the impact of mutations in autism
    NIH R01MH105524Sep 25, 2014 - May 31, 2018
    Role: Principal Investigator
    Protein network of high risk copy number variants for psychiatric disorders
    NIH R21MH104766Jul 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Schizophrenia interactome mapping and global discovery of brain splice variants
    NIH R01MH091350May 20, 2010 - Mar 31, 2015
    Role: Principal Investigator
    A systems biology approach to unravel theunderlying functional modules of ASD
    NIH R01HD065288Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Protein structural disorder and ubiquitination
    NIH R21CA113711Aug 2, 2007 - Jul 31, 2010
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Correction to: Therapeutic strategies for autism: targeting three levels of the central dogma of molecular biology. Transl Psychiatry. 2023 Mar 07; 13(1):80. Hong D, Iakoucheva LM. PMID: 36882413; PMCID: PMC9992495.
      View in: PubMed   Mentions:
    2. Therapeutic strategies for autism: targeting three levels of the central dogma of molecular biology. Transl Psychiatry. 2023 Feb 16; 13(1):58. Hong D, Iakoucheva LM. PMID: 36792602; PMCID: PMC9931756.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Author Correction: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2023 Feb 02; 14(1):569. Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Wanamaker SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM. PMID: 36732511; PMCID: PMC9895433.
      View in: PubMed   Mentions:    Fields:    
    4. How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain. bioRxiv. 2023 Jan 27. Jang H, Chen J, Iakoucheva LM, Nussinov R. PMID: 36747841; PMCID: PMC9900933.
      View in: PubMed   Mentions:
    5. Multi-objective prioritization of genes for high-throughput functional assays towards improved clinical variant classification. Pac Symp Biocomput. 2023; 28:323-334. Chen Y, Jain S, Zeiberg D, Iakoucheva LM, Mooney SD, Radivojac P, Pejaver V. PMID: 36540988.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nat Genet. 2022 Aug; 54(8):1259. Antaki D, Guevara J, Maihofer AX, Klein M, Gujral M, Grove J, Carey CE, Hong O, Arranz MJ, Hervas A, Corsello C, Vaux KK, Muotri AR, Iakoucheva LM, Courchesne E, Pierce K, Gleeson JG, Robinson EB, Nievergelt CM, Sebat J. PMID: 35768728.
      View in: PubMed   Mentions: 1     Fields:    
    7. A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nat Genet. 2022 09; 54(9):1284-1292. Antaki D, Guevara J, Maihofer AX, Klein M, Gujral M, Grove J, Carey CE, Hong O, Arranz MJ, Hervas A, Corsello C, Vaux KK, Muotri AR, Iakoucheva LM, Courchesne E, Pierce K, Gleeson JG, Robinson EB, Nievergelt CM, Sebat J. PMID: 35654974; PMCID: PMC9474668.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. Correction: Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry. 2021 Dec; 26(12):7581. Urresti J, Zhang P, Moran-Losada P, Yu NK, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates Iii JR, Muotri AR, Iakoucheva LM. PMID: 34548630; PMCID: PMC9119232.
      View in: PubMed   Mentions: 4     Fields:    
    9. Prioritizing de novo autism risk variants with calibrated gene- and variant-scoring models. Hum Genet. 2022 Oct; 141(10):1595-1613. Jiang Y, Urresti J, Pagel KA, Pramod AB, Iakoucheva LM, Radivojac P. PMID: 34549350; PMCID: PMC8938308.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Full-length isoform transcriptome of the developing human brain provides further insights into autism. Cell Rep. 2021 08 31; 36(9):109631. Chau KK, Zhang P, Urresti J, Amar M, Pramod AB, Chen J, Thomas A, Corominas R, Lin GN, Iakoucheva LM. PMID: 34469739; PMCID: PMC8437376.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    11. Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry. 2021 12; 26(12):7560-7580. Urresti J, Zhang P, Moran-Losada P, Yu NK, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates Iii JR, Muotri AR, Iakoucheva LM. PMID: 34433918; PMCID: PMC8873019.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    12. Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling. Mol Psychiatry. 2021 07; 26(7):3586-3613. Amar M, Pramod AB, Yu NK, Herrera VM, Qiu LR, Moran-Losada P, Zhang P, Trujillo CA, Ellegood J, Urresti J, Chau K, Diedrich J, Chen J, Gutierrez J, Sebat J, Ramanathan D, Lerch JP, Yates JR, Muotri AR, Iakoucheva LM. PMID: 33727673; PMCID: PMC8443683.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    13. Inferring the molecular and phenotypic impact of amino acid variants with MutPred2. Nat Commun. 2020 11 20; 11(1):5918. Pejaver V, Urresti J, Lugo-Martinez J, Pagel KA, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 33219223; PMCID: PMC7680112.
      View in: PubMed   Mentions: 104     Fields:    Translation:Humans
    14. Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development. Cell Rep. 2019 09 24; 28(13):3320-3328.e4. Qiu Y, Arbogast T, Lorenzo SM, Li H, Tang SC, Richardson E, Hong O, Cho S, Shanta O, Pang T, Corsello C, Deutsch CK, Chevalier C, Davis EE, Iakoucheva LM, Herault Y, Katsanis N, Messer K, Sebat J. PMID: 31553903; PMCID: PMC6988705.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Getting to the Cores of Autism. Cell. 2019 09 05; 178(6):1287-1298. Iakoucheva LM, Muotri AR, Sebat J. PMID: 31491383; PMCID: PMC7039308.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    16. Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome. PLoS Comput Biol. 2019 06; 15(6):e1007112. Pagel KA, Antaki D, Lian A, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 31199787; PMCID: PMC6594643.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    17. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018 12 14; 362(6420). Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE, PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH. PMID: 30545856; PMCID: PMC6443102.
      View in: PubMed   Mentions: 334     Fields:    Translation:HumansCells
    18. Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 04 20; 360(6386):327-331. Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. PMID: 29674594; PMCID: PMC6449150.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    19. When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants. Bioinformatics. 2017 Jul 15; 33(14):i389-i398. Pagel KA, Pejaver V, Lin GN, Nam HJ, Mort M, Cooper DN, Sebat J, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 28882004; PMCID: PMC5870554.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    20. Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases. Methods Mol Biol. 2017; 1613:371-402. Lin GN, Corominas R, Nam HJ, Urresti J, Iakoucheva LM. PMID: 28849569; PMCID: PMC5699888.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 07; 98(4):667-79. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. PMID: 27018473; PMCID: PMC4833290.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    22. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11; 164(4):805-17. Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M. PMID: 26871637; PMCID: PMC4882190.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    23. Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases. Neuron. 2015 Feb 18; 85(4):742-54. Lin GN, Corominas R, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM. PMID: 25695269; PMCID: PMC4335356.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    24. A proteome-scale map of the human interactome network. Cell. 2014 Nov 20; 159(5):1212-1226. Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barab?si AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M. PMID: 25416956; PMCID: PMC4266588.
      View in: PubMed   Mentions: 585     Fields:    Translation:HumansAnimals
    25. Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases. Chem Rev. 2014 Jul 09; 114(13):6844-79. Uversky VN, Dav? V, Iakoucheva LM, Malaney P, Metallo SJ, Pathak RR, Joerger AC. PMID: 24830552; PMCID: PMC4100540.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    26. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2014 Apr 11; 5:3650. Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM. PMID: 24722188; PMCID: PMC3996537.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    27. Predicted disorder-to-order transition mutations in I?Ba disrupt function. Phys Chem Chem Phys. 2014 Apr 14; 16(14):6480-5. Dembinski H, Wismer K, Balasubramaniam D, Gonzalez HA, Alverdi V, Iakoucheva LM, Komives EA. PMID: 24605363; PMCID: PMC4040282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. Whole-genome sequencing in autism identifies hot spots for de novo germline mutation. Cell. 2012 Dec 21; 151(7):1431-42. Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, Corominas R, Peoples A, Koren A, Gore A, Kang S, Lin GN, Estabillo J, Gadomski T, Singh B, Zhang K, Akshoomoff N, Corsello C, McCarroll S, Iakoucheva LM, Li Y, Wang J, Sebat J. PMID: 23260136; PMCID: PMC3712641.
      View in: PubMed   Mentions: 272     Fields:    Translation:HumansAnimalsCells
    29. Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder. PLoS Comput Biol. 2012; 8(10):e1002709. Vacic V, Markwick PR, Oldfield CJ, Zhao X, Haynes C, Uversky VN, Iakoucheva LM. PMID: 23055912; PMCID: PMC3464192.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    30. Disease mutations in disordered regions--exception to the rule? Mol Biosyst. 2012 Jan; 8(1):27-32. Vacic V, Iakoucheva LM. PMID: 22080206; PMCID: PMC3307532.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    31. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 2011 Mar 24; 471(7339):499-503. Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, Craig D, Kelsoe JR, Gershon ES, Leal SM, Dell Aquila M, Morris DW, Gill M, Corvin A, Insel PA, McClellan J, King MC, Karayiorgou M, Levy DL, DeLisi LE, Sebat J. PMID: 21346763; PMCID: PMC3351382.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCells
    32. Mapping copy number variation by population-scale genome sequencing. Nature. 2011 Feb 03; 470(7332):59-65. Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, Hormozdiari F, Iakoucheva LM, Iqbal Z, Kang S, Kidd JM, Konkel MK, Korn J, Khurana E, Kural D, Lam HY, Leng J, Li R, Li Y, Lin CY, Luo R, Mu XJ, Nemesh J, Peckham HE, Rausch T, Scally A, Shi X, Stromberg MP, St?tz AM, Urban AE, Walker JA, Wu J, Zhang Y, Zhang ZD, Batzer MA, Ding L, Marth GT, McVean G, Sebat J, Snyder M, Wang J, Ye K, Eichler EE, Gerstein MB, Hurles ME, Lee C, McCarroll SA, Korbel JO, 1000 Genomes Project. PMID: 21293372; PMCID: PMC3077050.
      View in: PubMed   Mentions: 584     Fields:    Translation:Humans
    33. Identification, analysis, and prediction of protein ubiquitination sites. Proteins. 2010 Feb 01; 78(2):365-80. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. PMID: 19722269; PMCID: PMC3006176.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansAnimalsCells
    34. Graphlet kernels for prediction of functional residues in protein structures. J Comput Biol. 2010 Jan; 17(1):55-72. Vacic V, Iakoucheva LM, Lonardi S, Radivojac P. PMID: 20078397; PMCID: PMC2921594.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    35. Loss of post-translational modification sites in disease. Pac Symp Biocomput. 2010; 337-47. Li S, Iakoucheva LM, Mooney SD, Radivojac P. PMID: 19908386; PMCID: PMC2813771.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    36. Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet. 2009 Nov; 41(11):1223-7. McCarthy SE, Makarov V, Kirov G, Addington AM, McClellan J, Yoon S, Perkins DO, Dickel DE, Kusenda M, Krastoshevsky O, Krause V, Kumar RA, Grozeva D, Malhotra D, Walsh T, Zackai EH, Kaplan P, Ganesh J, Krantz ID, Spinner NB, Roccanova P, Bhandari A, Pavon K, Lakshmi B, Leotta A, Kendall J, Lee YH, Vacic V, Gary S, Iakoucheva LM, Crow TJ, Christian SL, Lieberman JA, Stroup TS, Lehtimäki T, Puura K, Haldeman-Englert C, Pearl J, Goodell M, Willour VL, Derosse P, Steele J, Kassem L, Wolff J, Chitkara N, McMahon FJ, Malhotra AK, Potash JB, Schulze TG, Nöthen MM, Cichon S, Rietschel M, Leibenluft E, Kustanovich V, Lajonchere CM, Sutcliffe JS, Skuse D, Gill M, Gallagher L, Mendell NR, Wellcome Trust Case Control Consortium, Craddock N, Owen MJ, O'Donovan MC, Shaikh TH, Susser E, Delisi LE, Sullivan PF, Deutsch CK, Rapoport J, Levy DL, King MC, Sebat J. PMID: 19855392; PMCID: PMC2951180.
      View in: PubMed   Mentions: 331     Fields:    Translation:HumansCells
    37. Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics. 2009 Jul 07; 10 Suppl 1:S7. Uversky VN, Oldfield CJ, Midic U, Xie H, Xue B, Vucetic S, Iakoucheva LM, Obradovic Z, Dunker AK. PMID: 19594884; PMCID: PMC2709268.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    38. A protein domain-based interactome network for C. elegans early embryogenesis. Cell. 2008 Aug 08; 134(3):534-45. Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, de Lichtervelde L, Mul JD, van de Peut D, Devos M, Simonis N, Yildirim MA, Cokol M, Kao HL, de Smet AS, Wang H, Schlaitz AL, Hao T, Milstein S, Fan C, Tipsword M, Drew K, Galli M, Rhrissorrakrai K, Drechsel D, Koller D, Roth FP, Iakoucheva LM, Dunker AK, Bonneau R, Gunsalus KC, Hill DE, Piano F, Tavernier J, van den Heuvel S, Hyman AA, Vidal M. PMID: 18692475; PMCID: PMC2596478.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    39. Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics. 2008; 9 Suppl 1:S1. Oldfield CJ, Meng J, Yang JY, Yang MQ, Uversky VN, Dunker AK. PMID: 18366598; PMCID: PMC2386051.
      View in: PubMed   Mentions: 253     Fields:    Translation:Cells
    40. RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins. Biochim Biophys Acta. 2008 Feb; 1780(2):214-25. Nikolakaki E, Drosou V, Sanidas I, Peidis P, Papamarcaki T, Iakoucheva LM, Giannakouros T. PMID: 18022399.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    41. Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. J Proteome Res. 2007 May; 6(5):1917-32. Xie H, Vucetic S, Iakoucheva LM, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN. PMID: 17391016; PMCID: PMC2588348.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    42. Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J Proteome Res. 2007 May; 6(5):1882-98. Xie H, Vucetic S, Iakoucheva LM, Oldfield CJ, Dunker AK, Uversky VN, Obradovic Z. PMID: 17391014; PMCID: PMC2543138.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    43. Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res. 2007 May; 6(5):1899-916. Vucetic S, Xie H, Iakoucheva LM, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN. PMID: 17391015; PMCID: PMC2588346.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    44. Prediction of intrinsic disorder and its use in functional proteomics. Methods Mol Biol. 2007; 408:69-92. Uversky VN, Radivojac P, Iakoucheva LM, Obradovic Z, Dunker AK. PMID: 18314578.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    45. Intrinsic disorder and functional proteomics. Biophys J. 2007 Mar 01; 92(5):1439-56. Radivojac P, Iakoucheva LM, Oldfield CJ, Obradovic Z, Uversky VN, Dunker AK. PMID: 17158572; PMCID: PMC1796814.
      View in: PubMed   Mentions: 297     Fields:    Translation:HumansAnimalsCells
    46. Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol. 2006 Aug 04; 2(8):e100. Haynes C, Oldfield CJ, Ji F, Klitgord N, Cusick ME, Radivojac P, Uversky VN, Vidal M, Iakoucheva LM. PMID: 16884331; PMCID: PMC1526461.
      View in: PubMed   Mentions: 253     Fields:    Translation:HumansAnimalsCells
    47. Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments. Bioinformatics. 2006 Jun 15; 22(12):1536-7. Vacic V, Iakoucheva LM, Radivojac P. PMID: 16632492.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansCells
    48. Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins. Nucleic Acids Res. 2006; 34(1):305-12. Haynes C, Iakoucheva LM. PMID: 16407336; PMCID: PMC1326245.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    49. Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J. 2005 Oct; 272(20):5129-48. Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN. PMID: 16218947.
      View in: PubMed   Mentions: 491     Fields:    Translation:HumansAnimalsCells
    50. Combining prediction, computation and experiment for the characterization of protein disorder. Curr Opin Struct Biol. 2004 Oct; 14(5):570-6. Bracken C, Iakoucheva LM, Romero PR, Dunker AK. PMID: 15465317.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    51. DisProt: a database of protein disorder. Bioinformatics. 2005 Jan 01; 21(1):137-40. Vucetic S, Obradovic Z, Vacic V, Radivojac P, Peng K, Iakoucheva LM, Cortese MS, Lawson JD, Brown CJ, Sikes JG, Newton CD, Dunker AK. PMID: 15310560.
      View in: PubMed   Mentions: 88     Fields:    Translation:Cells
    52. The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res. 2004; 32(3):1037-49. Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes JG, Obradovic Z, Dunker AK. PMID: 14960716; PMCID: PMC373391.
      View in: PubMed   Mentions: 623     Fields:    Translation:AnimalsCells
    53. Order, disorder, and flexibility: prediction from protein sequence. Structure. 2003 Nov; 11(11):1316-7. Iakoucheva LM, Dunker AK. PMID: 14604521.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    54. Intrinsic disorder in cell-signaling and cancer-associated proteins. J Mol Biol. 2002 Oct 25; 323(3):573-84. Iakoucheva LM, Brown CJ, Lawson JD, Obradovic Z, Dunker AK. PMID: 12381310.
      View in: PubMed   Mentions: 486     Fields:    Translation:HumansCells
    55. Intrinsic disorder and protein function. Biochemistry. 2002 May 28; 41(21):6573-82. Dunker AK, Brown CJ, Lawson JD, Iakoucheva LM, Obradovic Z. PMID: 12022860.
      View in: PubMed   Mentions: 676     Fields:    Translation:Cells
    56. Equilibrium and stop-flow kinetic studies of fluorescently labeled DNA substrates with DNA repair proteins XPA and replication protein A. Biochemistry. 2002 Jan 08; 41(1):131-43. Iakoucheva LM, Walker RK, van Houten B, Ackerman EJ. PMID: 11772010.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    57. Single-molecule conformational dynamics of fluctuating noncovalent DNA-protein interactions in DNA damage recognition. J Am Chem Soc. 2001 Sep 19; 123(37):9184-5. Lu HP, Iakoucheva LM, Ackerman EJ. PMID: 11552836.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    58. Aberrant mobility phenomena of the DNA repair protein XPA. Protein Sci. 2001 Jul; 10(7):1353-62. Iakoucheva LM, Kimzey AL, Masselon CD, Smith RD, Dunker AK, Ackerman EJ. PMID: 11420437; PMCID: PMC2374115.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    59. Identification of intrinsic order and disorder in the DNA repair protein XPA. Protein Sci. 2001 Mar; 10(3):560-71. Iakoucheva LM, Kimzey AL, Masselon CD, Bruce JE, Garner EC, Brown CJ, Dunker AK, Smith RD, Ackerman EJ. PMID: 11344324; PMCID: PMC2374143.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    60. Nucleotide excision repair in oocyte nuclear extracts from Xenopus laevis. Methods. 2000 Oct; 22(2):188-93. Ackerman EJ, Iakoucheva LM. PMID: 11020334.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    61. Extended X-ray absorption fine structure evidence for a single metal binding domain in Xenopus laevis nucleotide excision repair protein XPA. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):109-13. Buchko GW, Iakoucheva LM, Kennedy MA, Ackerman EJ, Hess NJ. PMID: 9920741.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
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