Laura Crotty Alexander

Title(s)Associate Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-5091-2660 Additional info
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    Collapse Biography 
    Collapse education and training
    Duke UniversityBS1997
    Duke UniversityMD2003School of Medicine
    Massachusetts General HospitalResidency2006Internal Medicine
    HarvardFellowship2010Pulmonary and Critical Care Medicine
    University of California San DiegoPostdoctoral Fellowship2011Pediatric Infectious Disease (Nizet Lab)
    Collapse awards and honors
    UCSD Department of Medicine2023  - 2024Excellence in Faculty Mentoring in Research
    AAMC2022  - 2023Mid-Career Women Faculty Professional Development Seminar
    UCSD School of Pharmacy2020  - 2021Professor of the Year, Excellence in Teaching Award
    American Lung Association 2020  - 2020Lung Healthcare Provider of the Year
    ATS2018  - 2018ATS Fellow
    ATS2017  - 2017Emerging Leaders Program
    ATS2015  - 2016Presidential Commendation
    ATS Respiratory Cell and Molecular Biology (RCMB) Assembly2015  - 2016Rising Star
    ATS2015  - 2016Young Investigator Award
    ATS, DDD Committee (Building Education to Advance Research (BEAR))2014  - 2015BEAR Cage Competition Finalist
    UCSD2013  - 2014National Centers for Leadership in Academic Medicine (NCLAM)
    NIH2009  - 2011Loan Repayment Program Recipient
    Department of Veterans Affairs2024  - 2028Senior Clinician Scientist Investigator Award (SCSI)
    UCSD Academic Senate2025  - 2026Distinguished Teaching Award

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Immunomodulation and Inflammation Caused by 4th-generation E-cigarettes in the Setting of Asthma
    NIH I01BX006447Oct 1, 2024 - Sep 30, 2028
    Role: Principal Investigator
    Cigarette Smoking-induced miR-483 Transversion Aggravates Pulmonary Hypertension
    TRDRP T34IP8179Jul 1, 2024 - Jun 30, 2026
    Role: Co-Investigator
    Cannabis, vaping, and lung structural abnormalities in asymptomatic users
    TRDRP T33IR6633Jul 1, 2023 - Jun 30, 2026
    Role: Co-Investigator
    Developing a Diverse Next Generation of Leaders in Respiratory Science
    NIH T32HL166127Jun 1, 2023 - May 31, 2028
    Role: Co-Investigator
    Research and Advocacy Training in Conventional and Electronic Forms of Tobacco
    TRDRP Smoke and Vape Free Scholars Initiative T32SR5359Mar 1, 2022 - Feb 28, 2026
    Role: PI
    Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When Vaped
    NIH/NHLBI K24HL155884Aug 1, 2021 - Jul 31, 2026
    Role: PI
    Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways disease
    NIH I01BX004767Oct 1, 2019 - Sep 30, 2023
    Role: Principal Investigator
    Impact of JUUL use on lung physiologic and immune health and systemic inflammation
    TRDRP T30IP0965Sep 1, 2019 - Aug 31, 2022
    Role: PI
    Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways disease
    Veterans Affairs VA MeritApr 19, 2019 - Apr 18, 2023
    Role: PI
    Inflammatory and organ injury effects of daily e-cigarette use
    California National Primate Research Center (CNPRC) Pilot Award May 1, 2018 - Apr 30, 2019
    Role: PI
    Alterations in pulmonary physiology in response to e-cigs, fibrosis, and acute lung injury
    UCSD Health Sciences Research Grant RS169RDec 1, 2017 - Dec 31, 2018
    Role: PI
    San Diego Team Asthma Management using Phenotypes (STAMP); PrecISE Network
    NIH/NHLBI Clinical Research Cooperative Agreement UG1 HL139117Oct 1, 2017 - Sep 28, 2022
    Role: Co-Investigator
    Inflammatory cardiovascular disease induced by autonomic effects of e-cigs
    TRDRP 26IP-0040Aug 1, 2017 - Jul 31, 2019
    Role: Co-Investigator
    Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory Pathways
    NIH R01HL137052Apr 1, 2017 - Dec 31, 2021
    Role: Principal Investigator
    Description: Now in no cost extension (NCE) until 12/31/2022.
    E-cigarette vapor decreases host defenses and promotes inflammatory pathways
    American Thoracic Society (ATS) Foundation Award for Outstanding Early Career Investigators ATS001Jan 1, 2017 - Dec 31, 2017
    Sleep, Hypoxia and Tumorigenesis Pilot Award
    ResMed ResMed001Jul 1, 2016 - Jun 30, 2018
    Role: Co-PI
    E-Cigarettes Promote Bacterial Virulence and are Toxic to Airway and Host Defense Cells
    AHA 16BGIA27790079Jan 1, 2016 - Dec 31, 2017
    Role: PI
    Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    NIH IK2BX001313Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Forecasting the global economic and health burden of chronic obstructive pulmonary disease from 2025 through 2050. Chest. 2025 Apr 18. Boers E, Allen A, Barrett M, Benjafield AV, Rice MB, Wedzicha JA, Kaye L, Zar HJ, Sinha S, Ozoh O, Crotty Alexander LE, Malhotra A. PMID: 40254152.
      View in: PubMed   Mentions:    Fields:    
    2. Cannabis consumption conundrum: weighing the risks of vaping and smoking. Am J Physiol Lung Cell Mol Physiol. 2025 May 01; 328(5):L698-L699. Perryman A, Crotty Alexander LE. PMID: 40185106.
      View in: PubMed   Mentions:    Fields:    
    3. Factors driving switching from vaping of e-cigarettes to smoking tobacco and initiation of multi-inhalant use. medRxiv. 2025 Mar 05. Banjo E, Ahadian Z, Kasaraneni N, Chang H, Perera S, Emory K, Crotty Alexander LE. PMID: 40093245; PMCID: PMC11908271.
      View in: PubMed   Mentions:
    4. E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model. Arch Toxicol. 2025 Mar; 99(3):1223-1236. Sayed IM, Chakraborty A, Inouye K, Dugan L, Tocci S, Advani I, Park K, Gaboyan S, Kasaraneni N, Ma B, Hazra TK, Das S, Crotty Alexander LE. PMID: 39786590.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. E-cigarette-induced changes in cell stress and mitochondrial function. Free Radic Biol Med. 2025 Feb 16; 228:329-338. Chitteti R, Zuniga-Hertz JP, Masso-Silva JA, Shin J, Niesman I, Bojanowski CM, Kumar AJ, Hepokoski M, Crotty Alexander LE, Patel HH, Roth DM. PMID: 39756490.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. E-cigarette vapor extract alters human eosinophil gene expression in an effect mediated by propylene glycol, glycerin, and nicotine. J Leukoc Biol. 2024 Nov 27; 116(6):1420-1431. Hogan NT, Castaneda-Castro FE, Logandha Ramamoorthy Premlal A, Brickner H, Mondal M, Herrera-De La Mata S, Vijayanand P, Crotty Alexander LE, Seumois G, Akuthota P. PMID: 39136235.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. B cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort. medRxiv. 2024 Oct 08. Moll M, Xu Z, Boueiz A, Ryu MH, Silverman EK, Cho MH, Hersh CP, Sauler M, Polverino F, Kinney GL, Curtis JL, Crotty-Alexander LE, Vollmers C, Castaldi PJ. PMID: 39417147; PMCID: PMC11483011.
      View in: PubMed   Mentions:
    8. E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model. bioRxiv. 2024 Aug 26. Sayed IM, Chakraborty A, Inouye K, Dugan L, Tocci S, Advani I, Park K, Hazra TK, Das S, Crotty Alexander LE. PMID: 39253444; PMCID: PMC11383026.
      View in: PubMed   Mentions:
    9. Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 10 03; 31(10):1465-1483.e6. Xu L, Tan C, Barr J, Talaba N, Verheyden J, Chin JS, Gaboyan S, Kasaraneni N, Elgamal RM, Gaulton KJ, Lin G, Afshar K, Golts E, Meier A, Crotty Alexander LE, Borok Z, Shen Y, Chung WK, McCulley DJ, Sun X. PMID: 39181129.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Dual Use of Cannabis with Tobacco Is Associated with Increased Sugary Food and Drink Intake in Young People. Int J Environ Res Public Health. 2024 Aug 02; 21(8). Malhotra N, Kasaraneni N, Ahadian Z, Chang H, Advani I, McDermott J, Truong C, Gaboyan S, Mittal A, Perryman A, Masso-Silva JA, Steeger CM, Bowler RP, Castaldi PJ, Sharma S, Crotty Alexander LE. PMID: 39200627; PMCID: PMC11354211.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Sci Transl Med. 2024 07 03; 16(754):eadi6887. Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, Crotty Alexander LE, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. PMID: 38959328; PMCID: PMC11272418.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. The paradox of the safer cigarette: understanding the pulmonary effects of electronic cigarettes. Eur Respir J. 2024 Jun; 63(6). Allbright K, Villandre J, Crotty Alexander LE, Zhang M, Benam KH, Evankovich J, Königshoff M, Chandra D. PMID: 38609098.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Through the Looking Glass: Revisiting Smoking and Health. NEJM Evid. 2024 Mar; 3(3):EVIDe2400020. Perryman A, Crotty Alexander LE. PMID: 38411446; PMCID: PMC12068506.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection. Nat Commun. 2023 Dec 09; 14(1):8169. Tapryal N, Chakraborty A, Saha K, Islam A, Pan L, Hosoki K, Sayed IM, Duran JM, Alcantara J, Castillo V, Tindle C, Sarker AH, Wakamiya M, Cardenas VJ, Sharma G, Crotty Alexander LE, Sur S, Sahoo D, Ghosh G, Das S, Ghosh P, Boldogh I, Hazra TK. PMID: 38071370; PMCID: PMC10710473.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Implementing Holistic Review Practices in a Pulmonary and Critical Care Fellowship. ATS Sch. 2023 Dec; 4(4):528-537. Bailey J, Desai B, Wang A, Sunwoo B, Kerr K, Mandel J, Crouch DR, Crotty Alexander LE. PMID: 38196677; PMCID: PMC10773494.
      View in: PubMed   Mentions: 6  
    16. Duration of intermittent hypoxia impacts metabolic outcomes and severity of murine NAFLD. Front Sleep. 2023; 2. Barnes LA, Xu Y, Sanchez-Azofra A, Moya EA, Zhang MP, Crotty Alexander LE, Malhotra A, Mesarwi O. PMID: 38077744; PMCID: PMC10704994.
      View in: PubMed   Mentions: 2  
    17. Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome. J Clin Sleep Med. 2023 08 01; 19(8):1447-1456. Sanchez-Azofra A, Gu W, Masso-Silva JA, Sanz-Rubio D, Marin-Oto M, Cubero P, Gil AV, Moya EA, Barnes LA, Mesarwi OA, Marin T, Simonson TS, Crotty Alexander LE, Marin JM, Malhotra A. PMID: 37082823; PMCID: PMC10394367.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Transcriptomic responses in the blood and sputum of cigarette smokers compared to e-cigarette vapers. Respir Res. 2023 May 18; 24(1):134. Perez MF, Yurieva M, Poddutoori S, Mortensen EM, Crotty Alexander LE, Williams A. PMID: 37208747; PMCID: PMC10196320.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Assessing Barriers to Implementation of Machine Learning and Artificial Intelligence-Based Tools in Critical Care: Web-Based Survey Study. JMIR Perioper Med. 2023 Jan 27; 6:e41056. Mlodzinski E, Wardi G, Viglione C, Nemati S, Crotty Alexander L, Malhotra A. PMID: 36705960; PMCID: PMC10013679.
      View in: PubMed   Mentions: 6  
    20. Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients. Cell Rep Med. 2023 02 21; 4(2):100935. Lam MTY, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. PMID: 36758547; PMCID: PMC9874047.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 01; 20(1):1-17. Rebuli ME, Rose JJ, Noël A, Croft DP, Benowitz NL, Cohen AH, Goniewicz ML, Larsen BT, Leigh N, McGraw MD, Melzer AC, Penn AL, Rahman I, Upson D, Crotty Alexander LE, Ewart G, Jaspers I, Jordt SE, Kligerman S, Loughlin CE, McConnell R, Neptune ER, Nguyen TB, Pinkerton KE, Witek TJ. PMID: 36584985; PMCID: PMC9819258.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansPHPublic Health
    22. A Problem for Generations: Impact of E-Cigarette Type on Immune Homeostasis. Am J Respir Crit Care Med. 2022 11 15; 206(10):1195-1197. Sullivan L, Crotty Alexander LE. PMID: 35816433; PMCID: PMC9746835.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    23. Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin. Front Immunol. 2022; 13:993720. Masso-Silva JA, Sakoulas G, Olay J, Groysberg V, Geriak M, Nizet V, Crotty Alexander LE, Meier A. PMID: 36341409; PMCID: PMC9632428.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Learning Outcomes in a Live Virtual versus In-Person Curriculum for Medical and Pharmacy Students. ATS Sch. 2022 Oct; 3(3):399-412. Nilaad SD, Lin E, Bailey J, Truong C, Gaboyan S, Mittal A, Best BM, Guluma K, Iglewicz A, Lander L, Evans S, Goldberg C, Crotty Alexander LE. PMID: 36312802; PMCID: PMC9585697.
      View in: PubMed   Mentions: 6  
    25. Electronic Cigarettes: A Pro-Con Review of the Current Literature. J Allergy Clin Immunol Pract. 2022 11; 10(11):2843-2851. Giovacchini CX, Crotty Alexander LE, Que LG. PMID: 35872217.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansPHPublic Health
    26. Electronic cigarette use and perceptions during COVID-19. Respir Med. 2022 Aug-Sep; 200:106925. Merz W, Magraner J, Gunge D, Advani I, Crotty Alexander LE, Oren E. PMID: 35797927; PMCID: PMC9250168.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    27. Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association. Circ Res. 2022 07 22; 131(3):e70-e82. Wold LE, Tarran R, Crotty Alexander LE, Hamburg NM, Kheradmand F, St Helen G, Wu JC, American Heart Association Council on Basic Cardiovascular Sciences; Council on Arteriosclerosis, Th. PMID: 35726609.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    28. Daily E-cigarette Use and the Surge in JUUL Sales: 2017-2019. Pediatrics. 2022 Jun 01; 149(6). Pierce JP, Zhang J, Crotty Alexander LE, Leas EC, Kealey S, White MM, Strong DR, Trinidad DR, McMenamin SB, Chen R, Benmarhnia T, Messer K. PMID: 35634883; PMCID: PMC9647987.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    29. Correction to: Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 Patients: A Case Series and Review of the Literature. Clin Infect Dis. 2022 May 30; 74(10):1889-1890. Masso-Silva JA, Moshensky A, Lam MTY, Odish M, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott R, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Crotty Alexander LE. PMID: 35416961; PMCID: PMC9327099.
      View in: PubMed   Mentions: 5     Fields:    
    30. Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice. Elife. 2022 04 12; 11. Moshensky A, Brand CS, Alhaddad H, Shin J, Masso-Silva JA, Advani I, Gunge D, Sharma A, Mehta S, Jahan A, Nilaad S, Olay J, Gu W, Simonson T, Almarghalani D, Pham J, Perera S, Park K, Al-Kolla R, Moon H, Das S, Byun MK, Shah Z, Sari Y, Heller Brown J, Crotty Alexander LE. PMID: 35411847; PMCID: PMC9005188.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    31. Impulsivity-Related Personality Traits as Predictors of E-Cigarette Use among Young Adults over Time. Subst Use Misuse. 2022; 57(7):1007-1013. Mittal A, Du A, Merz W, Myers MG, Crotty Alexander LE, Doran N. PMID: 35382679; PMCID: PMC9214665.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 04; 604(7905):337-342. Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. PMID: 35355021; PMCID: PMC9165753.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    33. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022 04 11; 57(7):839-853.e6. Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. PMID: 35303432; PMCID: PMC9137452.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    34. Pulmonary and Critical Care Considerations for e-Cigarette, or Vaping, Product Use-Associated Lung Injury. Chest. 2022 07; 162(1):256-264. Hayes D, Board A, Calfee CS, Ellington S, Pollack LA, Kathuria H, Eakin MN, Weissman DN, Callahan SJ, Esper AM, Crotty Alexander LE, Sharma NS, Meyer NJ, Smith LS, Novosad S, Evans ME, Goodman AB, Click ES, Robinson RT, Ewart G, Twentyman E. PMID: 35257738.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Dual use of e-cigarettes with conventional tobacco is associated with increased sleep latency in cross-sectional Study. Sci Rep. 2022 02 15; 12(1):2536. Advani I, Gunge D, Boddu S, Mehta S, Park K, Perera S, Pham J, Nilaad S, Olay J, Ma L, Masso-Silva J, Sun X, Jain S, Malhotra A, Crotty Alexander LE. PMID: 35169234; PMCID: PMC8847556.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature. Clin Infect Dis. 2022 02 11; 74(3):479-489. Masso-Silva JA, Moshensky A, Lam MTY, Odish MF, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott RK, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Crotty Alexander LE. PMID: 33988226; PMCID: PMC8241438.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    37. Beware, vaping e-cigarettes around children is adversely impacting their lung health. Thorax. 2022 07; 77(7):638-639. Fuentes AL, Crotty Alexander LE. PMID: 35012999.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Just When We Thought Nothing Could Be Worse Than Smoking Tobacco, Vaping e-Hookah Proves Us Wrong. Chest. 2022 01; 161(1):13-15. Masso-Silva JA, Crotty Alexander LE. PMID: 35000699.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. A census of the lung: CellCards from LungMAP. Dev Cell. 2022 01 10; 57(1):112-145.e2. Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Masso-Silva JA, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE, NHLBI LungMAP Consortium. PMID: 34936882; PMCID: PMC9202574.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    40. Deleterious Association of Inhalant Use on Sleep Quality during the COVID-19 Pandemic. Int J Environ Res Public Health. 2021 12 15; 18(24). Gunge D, Marganski J, Advani I, Boddu S, Chen YJE, Mehta S, Merz W, Fuentes AL, Malhotra A, Banks SJ, Crotty Alexander LE. PMID: 34948812; PMCID: PMC8703610.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    41. E-liquids and vaping devices: public policy regarding their effects on young people and health. Med J Aust. 2022 01 17; 216(1):23-24. Advani IN, Perez M, Crotty Alexander LE. PMID: 34863086; PMCID: PMC8862754.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 02; 149(2):488-516.e9. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P, PrecISE Study Team. PMID: 34848210; PMCID: PMC8821377.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    43. Vaping and Lung Inflammation and Injury. Annu Rev Physiol. 2022 02 10; 84:611-629. Park JA, Crotty Alexander LE, Christiani DC. PMID: 34724436; PMCID: PMC10228557.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    44. Assessing the potential impact of age and inhalant use on sleep in adolescents. J Clin Sleep Med. 2021 11 01; 17(11):2233-2239. Malhotra CK, Gunge D, Advani I, Boddu S, Nilaad S, Crotty Alexander LE. PMID: 34027889; PMCID: PMC8636377.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    45. Inflammatory phenotype modulation in the respiratory tract and systemic circulation of e-cigarette users: a pilot study. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1134-L1146. Sayed IM, Masso-Silva JA, Mittal A, Patel A, Lin E, Moshensky A, Shin J, Bojanowski CM, Das S, Akuthota P, Crotty Alexander LE. PMID: 34704852; PMCID: PMC8715026.
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    46. Mental Health Symptoms Among US Medical School Applicants During the COVID-19 Pandemic. Prim Care Companion CNS Disord. 2021 09 30; 23(5). Light MP, Gunge D, LaBuzetta JN, Advani I, Crotty Alexander LE, Kamdar BB. PMID: 34592797; PMCID: PMC9011921.
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    47. Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19. bioRxiv. 2021 Aug 24. Lam MTY, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. PMID: 34462742; PMCID: PMC8404884.
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    48. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv. 2021 08; 7(34). Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. PMID: 34407940; PMCID: PMC8373124.
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    49. Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19. Elife. 2021 08 13; 10. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar GD, Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das S. PMID: 34463615; PMCID: PMC8463074.
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    50. Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex. ERJ Open Res. 2021 Jul; 7(3). Moshensky A, Du M, Shin J, Advani I, Gunge D, Mathew D, Alkolla R, Du A, Javier C, Ma L, Tran A, Nguyen N, Olay J, Nilaad S, Ding J, Najhawan M, Watrous JD, Bojanowksi CM, Jain M, Christiani DC, Crotty Alexander LE. PMID: 34262972; PMCID: PMC8273396.
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    51. Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2. Front Physiol. 2021; 12:649604. Masso-Silva JA, Moshensky A, Shin J, Olay J, Nilaad S, Advani I, Bojanowski CM, Crotty S, Li WT, Ongkeko WM, Singla S, Crotty Alexander LE. PMID: 34122126; PMCID: PMC8194307.
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    52. Compositional Differences in the Oral Microbiome of E-cigarette Users. Front Microbiol. 2021; 12:599664. Chopyk J, Bojanowski CM, Shin J, Moshensky A, Fuentes AL, Bonde SS, Chuki D, Pride DT, Crotty Alexander LE. PMID: 34135868; PMCID: PMC8200533.
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    53. Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19. bioRxiv. 2021 May 05. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar G, Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das S. PMID: 33106807; PMCID: PMC7587781.
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    54. An International Virtual COVID-19 Critical Care Training Forum for Healthcare Workers. ATS Sch. 2021 Jun; 2(2):278-286. Cypro A, McGuire WC, Rolfsen M, Jones N, Shah NG, Cribbs SK, Kaul V, Bojanowski CM, Pedraza I, Lynch L, Guzman L, Larsson E, Crotty Alexander LE. PMID: 34409421; PMCID: PMC8362763.
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    55. Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L821-L831. Hepokoski M, Wang J, Li K, Li Y, Gupta P, Mai T, Moshensky A, Alotaibi M, Crotty Alexander LE, Malhotra A, Singh P. PMID: 33565357; PMCID: PMC8174821.
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    56. E-cigarettes compromise the gut barrier and trigger inflammation. iScience. 2021 Feb 19; 24(2):102035. Sharma A, Lee J, Fonseca AG, Moshensky A, Kothari T, Sayed IM, Ibeawuchi SR, Pranadinata RF, Ear J, Sahoo D, Crotty-Alexander LE, Ghosh P, Das S. PMID: 33537654; PMCID: PMC7841355.
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    57. Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2021 01; 64(1):89-99. Zeng Z, Chen W, Moshensky A, Shakir Z, Khan R, Crotty Alexander LE, Ware LB, Aldaz CM, Jacobson JR, Dudek SM, Natarajan V, Machado RF, Singla S. PMID: 33058734; PMCID: PMC7780991.
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    58. Development of a National Academic Boot Camp to Improve Fellowship Readiness. ATS Sch. 2020 Dec 22; 2(1):49-65. Drake MG, Shah NG, Lee M, Brady A, Connors GR, Clark BJ, Kritek PA, McCallister JW, Burkart KM, Pedraza I, Jamieson D, Ingram JL, Lynch L, Makani SS, Siegel-Gasiewski J, Larsson EM, Zemanick ET, Liptzin DR, Good R, Crotty Alexander LE. PMID: 33870323; PMCID: PMC8043273.
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    59. E-cigarettes and health risks: more to the flavor than just the name. Am J Physiol Lung Cell Mol Physiol. 2021 04 01; 320(4):L600-L614. Ween MP, Moshensky A, Thredgold L, Bastian NA, Hamon R, Badiei A, Nguyen PT, Herewane K, Jersmann H, Bojanowski CM, Shin J, Reynolds PN, Crotty Alexander LE, Hodge SJ. PMID: 33295836; PMCID: PMC8424560.
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    60. Critical Care Education in a Pandemic through Tele-ICU. ATS Sch. 2020 Dec 03; 2(1):29-33. Leverone NA, Ramnath VR, Munce D, Raphelson JR, Ma J, Akuthota P, Tomaszewski C, Sell RE, Crotty Alexander LE, Akrami KM, Malhotra A. PMID: 33870321; PMCID: PMC8043279.
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    61. Bleomycin-induced lung injury treated with venovenous extracorporeal membrane oxygenation (ECMO) and ultra-protective ventilator settings. BMJ Case Rep. 2020 Nov 23; 13(11). Odish MF, McGuire WC, Thistlethwaite P, Crotty Alexander LE. PMID: 33229479; PMCID: PMC7684647.
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    62. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Chem Biol Interact. 2021 Jan 05; 333:109308. Alasmari F, Crotty Alexander LE, Hammad AM, Horton A, Alhaddad H, Schiefer IT, Shin J, Moshensky A, Sari Y. PMID: 33242460; PMCID: PMC7752837.
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    63. Vaping disrupts ventilation-perfusion matching in asymptomatic users. J Appl Physiol (1985). 2021 02 01; 130(2):308-317. Kizhakke Puliyakote AS, Elliott AR, Sá RC, Anderson KM, Crotty Alexander LE, Hopkins SR. PMID: 33180648; PMCID: PMC7948111.
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    64. Vaping and e-cigarette use. Mysterious lung manifestations and an epidemic. Curr Opin Immunol. 2020 10; 66:143-150. Casey AM, Muise ED, Crotty Alexander LE. PMID: 33186869; PMCID: PMC7755270.
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    65. Effects of 3-Month Exposure to E-Cigarette Aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice. Toxics. 2020 Oct 29; 8(4). Alhaddad H, Wong W, Sari AT, Crotty Alexander LE, Sari Y. PMID: 33137879; PMCID: PMC7712012.
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    66. Vaping-related lung injury. Virchows Arch. 2021 Jan; 478(1):81-88. Smith ML, Gotway MB, Crotty Alexander LE, Hariri LP. PMID: 33106908; PMCID: PMC7590536.
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    67. Cigarette Smoke Exposure Promotes Virulence of Pseudomonas aeruginosa and Induces Resistance to Neutrophil Killing. Infect Immun. 2020 10 19; 88(11). Chien J, Hwang JH, Nilaad S, Masso-Silva JA, Jeong Ahn S, McEachern EK, Moshensky A, Byun MK, Crotty Alexander LE. PMID: 32868344; PMCID: PMC7573448.
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    68. Effects of e-cigarettes and vaping devices on cardiac and pulmonary physiology. J Physiol. 2020 11; 598(22):5039-5062. Tsai M, Byun MK, Shin J, Crotty Alexander LE. PMID: 32975834; PMCID: PMC10506663.
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    69. E-Cigarette or Vaping Product Use-associated Lung Injury: Developing a Research Agenda. An NIH Workshop Report. Am J Respir Crit Care Med. 2020 09 15; 202(6):795-802. Crotty Alexander LE, Ware LB, Calfee CS, Callahan SJ, Eissenberg T, Farver C, Goniewicz ML, Jaspers I, Kheradmand F, King TE, Meyer NJ, Mikheev VB, Shields PG, Shihadeh A, Strongin R, Tarran R. PMID: 32243764; PMCID: PMC7491408.
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    70. Response. Chest. 2020 08; 158(2):836-837. Chapman DG, Larcombe AN, Bozier J, Chivers EK, Crotty Alexander LE, Ween MP. PMID: 32768076.
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    71. Reply: E-Cigarette, or Vaping, Product Use-associated Lung Injury: A Response to Perez and Crotty Alexander. Ann Am Thorac Soc. 2020 07; 17(7):908. Perez MF, Crotty Alexander LE. PMID: 32320261; PMCID: PMC7328184.
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    72. Is Increased Sleep Responsible for Reductions in Myocardial Infarction During the COVID-19 Pandemic? Am J Cardiol. 2020 09 15; 131:128-130. Advani I, Gunge D, Banks S, Mehta S, Park K, Patel M, Malhotra A, Crotty Alexander LE. PMID: 32703526; PMCID: PMC7305870.
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    73. Why Is Vaping Going Up in Flames? Ann Am Thorac Soc. 2020 05; 17(5):545-549. Perez MF, Crotty Alexander LE. PMID: 31944819; PMCID: PMC7263393.
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    74. Reply to Letter to the Editor: "Comment on 'E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation'". Am J Physiol Cell Physiol. 2020 03 01; 318(3):C706. Crotty Alexander LE, Meier A. PMID: 32150454.
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    75. The Evolving Landscape of e-Cigarettes: A Systematic Review of Recent Evidence. Chest. 2020 05; 157(5):1362-1390. Bozier J, Chivers EK, Chapman DG, Larcombe AN, Bastian NA, Masso-Silva JA, Byun MK, McDonald CF, Crotty Alexander LE, Ween MP. PMID: 32006591.
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    76. Use of Electronic Cigarettes with Conventional Tobacco Is Associated with Decreased Sleep Quality in Women. Am J Respir Crit Care Med. 2019 12 01; 200(11):1431-1434. Boddu SA, Bojanowski CM, Lam MT, Advani IN, Scholten EL, Sun X, Montgrain P, Malhotra A, Jain S, Alexander LEC. PMID: 31314572; PMCID: PMC6884046.
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    77. E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation. Am J Physiol Cell Physiol. 2020 01 01; 318(1):C205-C214. Corriden R, Moshensky A, Bojanowski CM, Meier A, Chien J, Nelson RK, Crotty Alexander LE. PMID: 31664858; PMCID: PMC6985828.
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    78. Design and Implementation of a Peer-Reviewed Medical Education Video Competition: The Best of American Thoracic Society Video Lecture Series. J Grad Med Educ. 2019 Oct; 11(5):592-596. Seam N, Richards JB, Kritek PA, Khemasuwan D, McCallister JW, Santhosh L, Prasad B, Bhargava S, Clay AS, Crotty Alexander LE. PMID: 31636831; PMCID: PMC6795340.
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    79. Vaping-associated Pulmonary Illness (VAPI). Am J Respir Crit Care Med. 2019 10 01; 200(7):P13-P14. Carlos WG, Crotty Alexander LE, Gross JE, Dela Cruz CS, Keller JM, Pasnick S, Jamil S. PMID: 31532695.
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    80. ATS Health Alert-Vaping-associated Pulmonary Illness (VAPI). Am J Respir Crit Care Med. 2019 10 01; 200(7):P15-P16. Carlos WG, Crotty Alexander LE, Gross JE, Dela Cruz CS, Keller JM, Pasnick S, Jamil S. PMID: 31532698.
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    81. Effects of Chronic Inhalation of Electronic Cigarette Vapor Containing Nicotine on Neurotransmitters in the Frontal Cortex and Striatum of C57BL/6 Mice. Front Pharmacol. 2019; 10:885. Alasmari F, Crotty Alexander LE, Hammad AM, Bojanowski CM, Moshensky A, Sari Y. PMID: 31456684; PMCID: PMC6699083.
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    82. Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF. J Immunol. 2019 07 15; 203(2):329-337. Nelson RK, Brickner H, Panwar B, Ramírez-Suástegui C, Herrera-de la Mata S, Liu N, Diaz D, Alexander LEC, Ay F, Vijayanand P, Seumois G, Akuthota P. PMID: 31175163; PMCID: PMC6616007.
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    83. Recommendations for the Appropriate Structure, Communication, and Investigation of Tobacco Harm Reduction Claims. An Official American Thoracic Society Policy Statement. Am J Respir Crit Care Med. 2018 10 15; 198(8):e90-e105. Leone FT, Carlsen KH, Chooljian D, Crotty Alexander LE, Detterbeck FC, Eakin MN, Evers-Casey S, Farber HJ, Folan P, Kathuria H, Latzka K, McDermott S, McGrath-Morrow S, Moazed F, Munzer A, Neptune E, Pakhale S, Sachs DPL, Samet J, Sufian B, Upson D. PMID: 30320525; PMCID: PMC6943880.
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    84. Ventilator-Induced Kidney Injury: Are Novel Biomarkers the Key to Prevention? Nephron. 2018; 140(2):90-93. Hepokoski ML, Malhotra A, Singh P, Crotty Alexander LE. PMID: 29996132; PMCID: PMC6165693.
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    85. Otolaryngology in Critical Care. Ann Am Thorac Soc. 2018 06; 15(6):643-654. Joshua J, Scholten E, Schaerer D, Mafee MF, Alexander TH, Crotty Alexander LE. PMID: 29565639; PMCID: PMC6207134.
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    86. A computerized exposure system for animal models to optimize nicotine delivery into the brain through inhalation of electronic cigarette vapors or cigarette smoke. Saudi Pharm J. 2018 Jul; 26(5):622-628. Alasmari F, Crotty Alexander LE, Drummond CA, Sari Y. PMID: 29989025; PMCID: PMC6035328.
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    87. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. PMID: 29384700; PMCID: PMC6032308.
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    88. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017 07 03; 77:1-8. Alasmari F, Crotty Alexander LE, Nelson JA, Schiefer IT, Breen E, Drummond CA, Sari Y. PMID: 28347687; PMCID: PMC5466499.
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    89. Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 03; 176:94-99. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander LE. PMID: 28093362.
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    90. Hypothesis: may e-cigarette smoking boost the allergic epidemic? Clin Transl Allergy. 2016; 6:40. Bousquet J, Bachert C, Alexander LC, Leone FT. PMID: 27891215; PMCID: PMC5111212.
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    91. Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F654-F660. Hepokoski M, Englert JA, Baron RM, Crotty-Alexander LE, Fuster MM, Beitler JR, Malhotra A, Singh P. PMID: 28365585; PMCID: PMC5407070.
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    92. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. Physiol Genomics. 2016 12 01; 48(12):950-960. Drummond CA, Crotty Alexander LE, Haller ST, Fan X, Xie JX, Kennedy DJ, Liu J, Yan Y, Hernandez DA, Mathew DP, Cooper CJ, Shapiro JI, Tian J. PMID: 27789733; PMCID: PMC5206391.
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    93. Spontaneous Pneumothorax Complicating Chronic Hepatic Hydrothorax: Successful Treatment by Small Bore Chest Tube. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):e43-e45. Hepokoski M, Makani SS, Lerner AD, Crotty Alexander LE. PMID: 27764014.
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    94. HIF2α-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8801-6. Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS. PMID: 27432976; PMCID: PMC4978263.
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    95. Global state of tobacco use: summary from the American Thoracic Society International Conference 2016. J Thorac Dis. 2016 Jul; 8(Suppl 7):S582-5. Shin S, Crotty Alexander LE. PMID: 27606101; PMCID: PMC4990678.
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    96. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J Mol Med (Berl). 2016 06; 94(6):667-79. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E, Mathew DP, Das S, Moshensky A, Bapat S, Pride DT, Ongkeko WM, Crotty Alexander LE. PMID: 26804311.
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    97. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016 Jan; 52:58-65. Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander LE, Brumund KT, Wang-Rodriguez J, Ongkeko WM. PMID: 26547127; PMCID: PMC4891196.
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    98. Inflammatory Diseases of the Lung Induced by Conventional Cigarette Smoke: A Review. Chest. 2015 Nov; 148(5):1307-1322. Crotty Alexander LE, Shin S, Hwang JH. PMID: 26135024.
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    99. Electronic cigarettes: the new face of nicotine delivery and addiction. J Thorac Dis. 2015 Aug; 7(8):E248-51. Crotty Alexander LE, Vyas A, Schraufnagel DE, Malhotra A. PMID: 26380791; PMCID: PMC4561260.
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    100. The Need for More E-Cigarette Data: A Call to Action. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):275-6. Crotty Alexander L, Fuster M, Montgrain P, Malhotra A. PMID: 26230232.
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    101. The Civil Liberty of Smoking Cigarettes. Chest. 2015 Jul; 148(1):6-8. Crotty Alexander LE, Malhotra A. PMID: 26149548.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    102. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun. 2015 Jun; 83(6):2443-52. McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander LE. PMID: 25824841; PMCID: PMC4432760.
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    103. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J Mol Med (Berl). 2014 Dec; 92(12):1305-17. Vega VL, Crotty Alexander LE, Charles W, Hwang JH, Nizet V, De Maio A. PMID: 25163764.
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    104. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One. 2013; 8(12):e84481. Crotty Alexander LE, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V. PMID: 24386389; PMCID: PMC3873454.
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    105. Epidermal deletion of HIF-2α stimulates wound closure. J Invest Dermatol. 2014 Mar; 134(3):801-808. Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS. PMID: 24037341; PMCID: PMC3877686.
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    106. Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model. Clin Immunol. 2013 Apr; 147(1):27-37. Baek KJ, Cho JY, Rosenthal P, Alexander LEC, Nizet V, Broide DH. PMID: 23499929; PMCID: PMC3812068.
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    107. Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. PMID: 23250618; PMCID: PMC3646920.
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    108. Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications. Cell Stress Chaperones. 2011 Sep; 16(5):573-81. Vega VL, Charles W, Crotty Alexander LE, Alexander LE. PMID: 21626279; PMCID: PMC3156255.
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    109. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010 Jan 05; 5(1):e8557. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. PMID: 20052280; PMCID: PMC2796718.
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    110. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med (Berl). 2010 Apr; 88(4):371-81. Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Köckritz-Blickwede M, Nizet V. PMID: 19960175; PMCID: PMC2843839.
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    111. Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. J Biol Chem. 2005 Jan 21; 280(3):1882-92. Laugel B, Boulter JM, Lissin N, Vuidepot A, Li Y, Gostick E, Crotty LE, Douek DC, Hemelaar J, Price DA, Jakobsen BK, Sewell AK. PMID: 15531581.
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    112. Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. Clin Cancer Res. 2003 Sep 15; 9(11):4247-54. Heimberger AB, Crotty LE, Archer GE, Hess KR, Wikstrand CJ, Friedman AH, Friedman HS, Bigner DD, Sampson JH. PMID: 14519652.
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    113. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003 Apr 01; 101(7):2711-20. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. PMID: 12433688.
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    114. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery. 2002 Jan; 50(1):158-64; discussion 164-6. Heimberger AB, Archer GE, Crotty LE, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Sampson JH. PMID: 11844246.
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    115. Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system. Cancer Immunol Immunother. 2002 Feb; 50(12):639-52. Wikstrand CJ, Cole VR, Crotty LE, Sampson JH, Bigner DD. PMID: 11862416; PMCID: PMC11034303.
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    116. Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7503-8. Sampson JH, Crotty LE, Lee S, Archer GE, Ashley DM, Wikstrand CJ, Hale LP, Small C, Dranoff G, Friedman AH, Friedman HS, Bigner DD. PMID: 10852962; PMCID: PMC16575.
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    117. Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma. J Neuroimmunol. 2000 Feb 01; 103(1):16-25. Heimberger AB, Crotty LE, Archer GE, McLendon RE, Friedman A, Dranoff G, Bigner DD, Sampson JH. PMID: 10674985.
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