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    Laura Crotty Alexander

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #9111J
    CA La Jolla 92093
    Emaillcrotty@ucsd.edu
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      Collapse Biography 
      Collapse Education and Training
      Duke UniversityBS1997
      Duke UniversityMD2003School of Medicine
      Massachusetts General HospitalResidency2006Internal Medicine
      HarvardFellowship2010Pulmonary and Critical Care Medicine
      University of California San DiegoPostdoctoral Fellowship2011Pediatric Infectious Disease (Nizet Lab)
      Collapse Awards and Honors
      Massachusetts General Hospital (MGH)2005  - 2006Humanities Award
      NIH2009  - 2011Loan Repayment Program Recipient
      ATS, MTPI Assembly2008  - 2009Travel Award
      UCSD2013  - 2014National Centers for Leadership in Academic Medicine (NCLAM)
      AAMC2013  - 2014Early Career Women Faculty Professional Development Seminar
      ATS, DDD Committee (Building Education to Advance Research (BEAR))2014  - 2015BEAR Cage Competition Finalist
      ATS2015  - 2016Young Investigator Award
      ATS2015  - 2016Presidential Commendation
      ATS2015  - 2016Rising Star, Respiratory Cell and Molecular Biology (RCMB) Assembly

      Collapse Research 
      Collapse Research Activities and Funding
      Alterations in pulmonary physiology in response to e-cigs, fibrosis, and acute lung injury
      UCSD Health Sciences Research Grant RS169RDec 1, 2017 - Dec 31, 2018
      Role: PI
      San Diego Team Asthma Management using Phenotypes (STAMP); PrecISE Network
      NIH/NHLBI Clinical Research Cooperative Agreement UG1 HL139117Oct 1, 2017 - Sep 28, 2022
      Role: Co-Investigator
      Inflammatory cardiovascular disease induced by autonomic effects of e-cigs
      TRDRP 26IP-0040Aug 1, 2017 - Jul 31, 2019
      Role: Co-Investigator
      Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory Pathways
      NIH/NHLBI R01HL137052Apr 1, 2017 - Dec 31, 2021
      Role: Principal Investigator
      E-cigarette vapor decreases host defenses and promotes inflammatory pathways
      American Thoracic Society (ATS) Foundation Award for Outstanding Early Career Investigators ATS001Jan 1, 2017 - Dec 31, 2017
      Sleep, Hypoxia and Tumorigenesis Pilot Award
      ResMed ResMed001Jul 1, 2016 - Jun 30, 2018
      Role: Co-PI
      E-Cigarettes Promote Bacterial Virulence and are Toxic to Airway and Host Defense Cells
      AHA 16BGIA27790079Jan 1, 2016 - Dec 31, 2017
      Role: PI
      Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
      VA IK2BX001313Aug 1, 2011 - Jul 31, 2016
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Alasmari F, Crotty Alexander L, Nelson JA, Schiefer IT, Breen E, Drummond CA, Sari Y. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and a-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 03; 77:1-8. PMID: 28347687.
        View in: PubMed
      2. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander L. Hypoxia-inducible factor-1a inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 Mar; 176:94-99. PMID: 28093362.
        View in: PubMed
      3. Hepokoski M, Makani SS, Lerner AD, Crotty Alexander L. Spontaneous Pneumothorax Complicating Chronic Hepatic Hydrothorax: Successful Treatment by Small Bore Chest Tube. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):e43-e45. PMID: 27764014.
        View in: PubMed
      4. Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander L, Morrell NW, Chilvers ER, Johnson RS. HIF2a-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci U S A. 2016 Aug 02; 113(31):8801-6. PMID: 27432976; PMCID: PMC4978263.
        View in: PubMed, PubMed Central
      5. Shin S, Crotty Alexander L. Global state of tobacco use: summary from the American Thoracic Society International Conference 2016. J Thorac Dis. 2016 Jul; 8(Suppl 7):S582-5. PMID: 27606101; PMCID: PMC4990678.
        View in: PubMed, PubMed Central
      6. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E, Mathew DP, Das S, Moshensky A, Bapat S, Pride DT, Ongkeko WM, Crotty Alexander L. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J Mol Med (Berl). 2016 Jun; 94(6):667-79. PMID: 26804311.
        View in: PubMed
      7. Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander L, Brumund KT, Wang-Rodriguez J, Ongkeko WM. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016 Jan; 52:58-65. PMID: 26547127; PMCID: PMC4891196 [Available on 01/01/17].
        View in: PubMed, PubMed Central
      8. Crotty Alexander L, Shin S, Hwang JH. Inflammatory Diseases of the Lung Induced by Conventional Cigarette Smoke: A Review. Chest. 2015 Nov; 148(5):1307-1322. PMID: 26135024.
        View in: PubMed
      9. Crotty Alexander L, Fuster M, Montgrain P, Malhotra A. The Need for More E-Cigarette Data: A Call to Action. Am J Respir Crit Care Med. 2015 Aug 1; 192(3):275-6. PMID: 26230232.
        View in: PubMed
      10. Crotty Alexander L, Vyas A, Schraufnagel DE, Malhotra A. Electronic cigarettes: the new face of nicotine delivery and addiction. J Thorac Dis. 2015 Aug; 7(8):E248-51. PMID: 26380791; PMCID: PMC4561260.
        View in: PubMed, PubMed Central
      11. Crotty Alexander L, Malhotra A. The Civil Liberty of Smoking Cigarettes. Chest. 2015 Jul 1; 148(1):6-8. PMID: 26149548.
        View in: PubMed
      12. McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander L. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun. 2015 Jun; 83(6):2443-52. PMID: 25824841; PMCID: PMC4432760.
        View in: PubMed, PubMed Central
      13. Vega VL, Crotty Alexander L, Charles W, Hwang JH, Nizet V, De Maio A. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J Mol Med (Berl). 2014 Dec; 92(12):1305-17. PMID: 25163764.
        View in: PubMed
      14. Crotty Alexander L, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One. 2013; 8(12):e84481. PMID: 24386389; PMCID: PMC3873454.
        View in: PubMed, PubMed Central
      15. Crotty Alexander L, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. Myeloid cell HIF-1a regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. PMID: 23250618; PMCID: PMC3646920.
        View in: PubMed, PubMed Central
      16. Vega VL, Charles W, Crotty Alexander L, Alexander LE. Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications. Cell Stress Chaperones. 2011 Sep; 16(5):573-81. PMID: 21626279; PMCID: PMC3156255.
        View in: PubMed, PubMed Central
      17. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010 Jan 05; 5(1):e8557. PMID: 20052280; PMCID: PMC2796718.
        View in: PubMed, PubMed Central
      18. Crotty Alexander L, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Köckritz-Blickwede M, Nizet V. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med (Berl). 2010 Apr; 88(4):371-81. PMID: 19960175; PMCID: PMC2843839.
        View in: PubMed, PubMed Central
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