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Laura Crotty Alexander

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #9111J
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Duke UniversityBS1997
    Duke UniversityMD2003School of Medicine
    Massachusetts General HospitalResidency2006Internal Medicine
    HarvardFellowship2010Pulmonary and Critical Care Medicine
    University of California San DiegoPostdoctoral Fellowship2011Pediatric Infectious Disease (Nizet Lab)
    Collapse Awards and Honors
    Massachusetts General Hospital (MGH)2005  - 2006Humanities Award
    NIH2009  - 2011Loan Repayment Program Recipient
    ATS, MTPI Assembly2008  - 2009Travel Award
    UCSD2013  - 2014National Centers for Leadership in Academic Medicine (NCLAM)
    AAMC2013  - 2014Early Career Women Faculty Professional Development Seminar
    ATS, DDD Committee (Building Education to Advance Research (BEAR))2014  - 2015BEAR Cage Competition Finalist
    ATS2015  - 2016Young Investigator Award
    ATS2015  - 2016Presidential Commendation
    ATS2015  - 2016Rising Star, Respiratory Cell and Molecular Biology (RCMB) Assembly

    Collapse Research 
    Collapse Research Activities and Funding
    Alterations in pulmonary physiology in response to e-cigs, fibrosis, and acute lung injury
    UCSD Health Sciences Research Grant RS169RDec 1, 2017 - Dec 31, 2018
    Role: PI
    San Diego Team Asthma Management using Phenotypes (STAMP); PrecISE Network
    NIH/NHLBI Clinical Research Cooperative Agreement UG1 HL139117Oct 1, 2017 - Sep 28, 2022
    Role: Co-Investigator
    Inflammatory cardiovascular disease induced by autonomic effects of e-cigs
    TRDRP 26IP-0040Aug 1, 2017 - Jul 31, 2019
    Role: Co-Investigator
    Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory Pathways
    NIH/NHLBI R01HL137052Apr 1, 2017 - Dec 31, 2021
    Role: Principal Investigator
    E-cigarette vapor decreases host defenses and promotes inflammatory pathways
    American Thoracic Society (ATS) Foundation Award for Outstanding Early Career Investigators ATS001Jan 1, 2017 - Dec 31, 2017
    Sleep, Hypoxia and Tumorigenesis Pilot Award
    ResMed ResMed001Jul 1, 2016 - Jun 30, 2018
    Role: Co-PI
    E-Cigarettes Promote Bacterial Virulence and are Toxic to Airway and Host Defense Cells
    AHA 16BGIA27790079Jan 1, 2016 - Dec 31, 2017
    Role: PI
    Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    VA IK2BX001313Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Joshua J, Scholten E, Schaerer D, Mafee MF, Alexander TH, Crotty Alexander L. Otolaryngology in Critical Care. Ann Am Thorac Soc. 2018 Mar 22. PMID: 29565639.
      View in: PubMed
    2. Crotty Alexander L, Drummond CA, Hepokoski M, Mathew DP, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. Chronic Inhalation of E-Cigarette Vapor Containing Nicotine Disrupts Airway Barrier Function and Induces Systemic Inflammation and Multi-Organ Fibrosis in Mice. Am J Physiol Regul Integr Comp Physiol. 2018 Jan 31. PMID: 29384700.
      View in: PubMed
    3. Alasmari F, Crotty Alexander L, Nelson JA, Schiefer IT, Breen E, Drummond CA, Sari Y. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and a-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 03; 77:1-8. PMID: 28347687.
      View in: PubMed
    4. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander L. Hypoxia-inducible factor-1a inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 03; 176:94-99. PMID: 28093362.
      View in: PubMed
    5. Drummond CA, Crotty Alexander L, Haller ST, Fan X, Xie JX, Kennedy DJ, Liu J, Yan Y, Hernandez DA, Mathew DP, Cooper CJ, Shapiro JI, Tian J. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. Physiol Genomics. 2016 Dec 01; 48(12):950-960. PMID: 27789733.
      View in: PubMed
    6. Hepokoski M, Makani SS, Lerner AD, Crotty Alexander L. Spontaneous Pneumothorax Complicating Chronic Hepatic Hydrothorax: Successful Treatment by Small Bore Chest Tube. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):e43-e45. PMID: 27764014.
      View in: PubMed
    7. Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander L, Morrell NW, Chilvers ER, Johnson RS. HIF2a-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8801-6. PMID: 27432976; PMCID: PMC4978263.
    8. Shin S, Crotty Alexander L. Global state of tobacco use: summary from the American Thoracic Society International Conference 2016. J Thorac Dis. 2016 Jul; 8(Suppl 7):S582-5. PMID: 27606101; PMCID: PMC4990678.
    9. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E, Mathew DP, Das S, Moshensky A, Bapat S, Pride DT, Ongkeko WM, Crotty Alexander L. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J Mol Med (Berl). 2016 06; 94(6):667-79. PMID: 26804311.
      View in: PubMed
    10. Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander L, Brumund KT, Wang-Rodriguez J, Ongkeko WM. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016 Jan; 52:58-65. PMID: 26547127; PMCID: PMC4891196 [Available on 01/01/17].
    11. Crotty Alexander L, Shin S, Hwang JH. Inflammatory Diseases of the Lung Induced by Conventional Cigarette Smoke: A Review. Chest. 2015 Nov; 148(5):1307-1322. PMID: 26135024.
      View in: PubMed
    12. Crotty Alexander L, Vyas A, Schraufnagel DE, Malhotra A. Electronic cigarettes: the new face of nicotine delivery and addiction. J Thorac Dis. 2015 Aug; 7(8):E248-51. PMID: 26380791; PMCID: PMC4561260.
    13. Crotty Alexander L, Fuster M, Montgrain P, Malhotra A. The Need for More E-Cigarette Data: A Call to Action. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):275-6. PMID: 26230232.
      View in: PubMed
    14. Crotty Alexander L, Malhotra A. The Civil Liberty of Smoking Cigarettes. Chest. 2015 Jul; 148(1):6-8. PMID: 26149548.
      View in: PubMed
    15. McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander L. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun. 2015 Jun; 83(6):2443-52. PMID: 25824841; PMCID: PMC4432760.
    16. Vega VL, Crotty Alexander L, Charles W, Hwang JH, Nizet V, De Maio A. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J Mol Med (Berl). 2014 Dec; 92(12):1305-17. PMID: 25163764.
      View in: PubMed
    17. Crotty Alexander L, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One. 2013; 8(12):e84481. PMID: 24386389; PMCID: PMC3873454.
    18. Crotty Alexander L, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. Myeloid cell HIF-1a regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. PMID: 23250618.
      View in: PubMed
    19. Vega VL, Charles W, Crotty Alexander L, Alexander LE. Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications. Cell Stress Chaperones. 2011 Sep; 16(5):573-81. PMID: 21626279; PMCID: PMC3156255.
    20. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010 Jan 05; 5(1):e8557. PMID: 20052280; PMCID: PMC2796718.
    21. Crotty Alexander L, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Köckritz-Blickwede M, Nizet V. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med (Berl). 2010 Apr; 88(4):371-81. PMID: 19960175; PMCID: PMC2843839.