Laura Crotty Alexander

Title(s)Associate Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-5091-2660 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Duke UniversityBS1997
    Duke UniversityMD2003School of Medicine
    Massachusetts General HospitalResidency2006Internal Medicine
    HarvardFellowship2010Pulmonary and Critical Care Medicine
    University of California San DiegoPostdoctoral Fellowship2011Pediatric Infectious Disease (Nizet Lab)
    Collapse Awards and Honors
    UCSD School of Pharmacy2020  - 2021Professor of the Year, Excellence in Teaching Award
    American Lung Association 2020  - 2020Lung Healthcare Provider of the Year
    ATS2018  - 2018ATS Fellow
    ATS2017  - 2017Emerging Leaders Program
    ATS2015  - 2016Presidential Commendation
    ATS2015  - 2016Rising Star, Respiratory Cell and Molecular Biology (RCMB) Assembly
    ATS2015  - 2016Young Investigator Award
    ATS, DDD Committee (Building Education to Advance Research (BEAR))2014  - 2015BEAR Cage Competition Finalist
    UCSD2013  - 2014National Centers for Leadership in Academic Medicine (NCLAM)
    NIH2009  - 2011Loan Repayment Program Recipient

    Collapse Overview 
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Research and Advocacy Training in Conventional and Electronic Forms of Tobacco
    TRDRP Smoke and Vape Free Scholars Initiative T32SR5359Mar 1, 2022 - Feb 28, 2026
    Role: PI
    Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When Vaped
    NIH/NHLBI K24HL155884Aug 1, 2021 - Jul 31, 2026
    Role: PI
    Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways disease
    NIH I01BX004767Oct 1, 2019 - Sep 30, 2023
    Role: Principal Investigator
    Impact of JUUL use on lung physiologic and immune health and systemic inflammation
    TRDRP T30IP0965Sep 1, 2019 - Aug 31, 2022
    Role: PI
    Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways disease
    Veterans Affairs VA MeritApr 19, 2019 - Apr 18, 2023
    Role: PI
    Inflammatory and organ injury effects of daily e-cigarette use
    California National Primate Research Center (CNPRC) Pilot Award May 1, 2018 - Apr 30, 2019
    Role: PI
    Alterations in pulmonary physiology in response to e-cigs, fibrosis, and acute lung injury
    UCSD Health Sciences Research Grant RS169RDec 1, 2017 - Dec 31, 2018
    Role: PI
    San Diego Team Asthma Management using Phenotypes (STAMP); PrecISE Network
    NIH/NHLBI Clinical Research Cooperative Agreement UG1 HL139117Oct 1, 2017 - Sep 28, 2022
    Role: Co-Investigator
    Inflammatory cardiovascular disease induced by autonomic effects of e-cigs
    TRDRP 26IP-0040Aug 1, 2017 - Jul 31, 2019
    Role: Co-Investigator
    Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory Pathways
    NIH R01HL137052Apr 1, 2017 - Dec 31, 2021
    Role: Principal Investigator
    Description: Now in no cost extension (NCE) until 12/31/2022.
    E-cigarette vapor decreases host defenses and promotes inflammatory pathways
    American Thoracic Society (ATS) Foundation Award for Outstanding Early Career Investigators ATS001Jan 1, 2017 - Dec 31, 2017
    Sleep, Hypoxia and Tumorigenesis Pilot Award
    ResMed ResMed001Jul 1, 2016 - Jun 30, 2018
    Role: Co-PI
    E-Cigarettes Promote Bacterial Virulence and are Toxic to Airway and Host Defense Cells
    AHA 16BGIA27790079Jan 1, 2016 - Dec 31, 2017
    Role: PI
    Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    NIH IK2BX001313Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Beware, vaping e-cigarettes around children is adversely impacting their lung health. Thorax. 2022 07; 77(7):638-639. Fuentes AL, Crotty Alexander LE. PMID: 35012999.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Just When We Thought Nothing Could Be Worse Than Smoking Tobacco, Vaping e-Hookah Proves Us Wrong. Chest. 2022 01; 161(1):13-15. Masso-Silva JA, Crotty Alexander LE. PMID: 35000699.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. A census of the lung: CellCards from LungMAP. Dev Cell. 2022 01 10; 57(1):112-145.e2. Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Masso-Silva JA, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE, NHLBI LungMAP Consortium. PMID: 34936882; PMCID: PMC9202574.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    4. Deleterious Association of Inhalant Use on Sleep Quality during the COVID-19 Pandemic. Int J Environ Res Public Health. 2021 12 15; 18(24). Gunge D, Marganski J, Advani I, Boddu S, Chen YJE, Mehta S, Merz W, Fuentes AL, Malhotra A, Banks SJ, Crotty Alexander LE. PMID: 34948812; PMCID: PMC8703610.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    5. E-liquids and vaping devices: public policy regarding their effects on young people and health. Med J Aust. 2022 01 17; 216(1):23-24. Advani IN, Perez M, Crotty Alexander LE. PMID: 34863086; PMCID: PMC8862754.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 02; 149(2):488-516.e9. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P, PrecISE Study Team. PMID: 34848210; PMCID: PMC8821377.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. Vaping and Lung Inflammation and Injury. Annu Rev Physiol. 2022 02 10; 84:611-629. Park JA, Crotty Alexander LE, Christiani DC. PMID: 34724436.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Assessing the potential impact of age and inhalant use on sleep in adolescents. J Clin Sleep Med. 2021 11 01; 17(11):2233-2239. Malhotra CK, Gunge D, Advani I, Boddu S, Nilaad S, Crotty Alexander LE. PMID: 34027889; PMCID: PMC8636377.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Inflammatory phenotype modulation in the respiratory tract and systemic circulation of e-cigarette users: a pilot study. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1134-L1146. Sayed IM, Masso-Silva JA, Mittal A, Patel A, Lin E, Moshensky A, Shin J, Bojanowski CM, Das S, Akuthota P, Crotty Alexander LE. PMID: 34704852; PMCID: PMC8715026.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Mental Health Symptoms Among US Medical School Applicants During the COVID-19 Pandemic. Prim Care Companion CNS Disord. 2021 09 30; 23(5). Light MP, Gunge D, LaBuzetta JN, Advani I, Crotty Alexander LE, Kamdar BB. PMID: 34592797; PMCID: PMC9011921.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    11. Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19. bioRxiv. 2021 Aug 24. Lam MTY, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. PMID: 34462742; PMCID: PMC8404884.
      View in: PubMed   Mentions: 2  
    12. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv. 2021 08; 7(34). Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. PMID: 34407940; PMCID: PMC8373124.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    13. Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19. Elife. 2021 08 13; 10. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar GD, Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das S. PMID: 34463615; PMCID: PMC8463074.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    14. Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex. ERJ Open Res. 2021 Jul; 7(3). Moshensky A, Du M, Shin J, Advani I, Gunge D, Mathew D, Alkolla R, Du A, Javier C, Ma L, Tran A, Nguyen N, Olay J, Nilaad S, Ding J, Najhawan M, Watrous JD, Bojanowksi CM, Jain M, Christiani DC, Crotty Alexander LE. PMID: 34262972; PMCID: PMC8273396.
      View in: PubMed   Mentions: 2  
    15. Compositional Differences in the Oral Microbiome of E-cigarette Users. Front Microbiol. 2021; 12:599664. Chopyk J, Bojanowski CM, Shin J, Moshensky A, Fuentes AL, Bonde SS, Chuki D, Pride DT, Crotty Alexander LE. PMID: 34135868; PMCID: PMC8200533.
      View in: PubMed   Mentions: 9  
    16. Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2. Front Physiol. 2021; 12:649604. Masso-Silva JA, Moshensky A, Shin J, Olay J, Nilaad S, Advani I, Bojanowski CM, Crotty S, Li WT, Ongkeko WM, Singla S, Crotty Alexander LE. PMID: 34122126; PMCID: PMC8194307.
      View in: PubMed   Mentions: 10  
    17. Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19. bioRxiv. 2021 May 05. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar G, Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das S. PMID: 33106807; PMCID: PMC7587781.
      View in: PubMed   Mentions: 1  
    18. An International Virtual COVID-19 Critical Care Training Forum for Healthcare Workers. ATS Sch. 2021 Jun; 2(2):278-286. Cypro A, McGuire WC, Rolfsen M, Jones N, Shah NG, Cribbs SK, Kaul V, Bojanowski CM, Pedraza I, Lynch L, Guzman L, Larsson E, Crotty Alexander LE. PMID: 34409421; PMCID: PMC8362763.
      View in: PubMed   Mentions: 2  
    19. Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L821-L831. Hepokoski M, Wang J, Li K, Li Y, Gupta P, Mai T, Moshensky A, Alotaibi M, Crotty Alexander LE, Malhotra A, Singh P. PMID: 33565357; PMCID: PMC8174821.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    20. E-cigarettes compromise the gut barrier and trigger inflammation. iScience. 2021 Feb 19; 24(2):102035. Sharma A, Lee J, Fonseca AG, Moshensky A, Kothari T, Sayed IM, Ibeawuchi SR, Pranadinata RF, Ear J, Sahoo D, Crotty-Alexander LE, Ghosh P, Das S. PMID: 33537654; PMCID: PMC7841355.
      View in: PubMed   Mentions: 16  
    21. Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2021 01; 64(1):89-99. Zeng Z, Chen W, Moshensky A, Shakir Z, Khan R, Crotty Alexander LE, Ware LB, Aldaz CM, Jacobson JR, Dudek SM, Natarajan V, Machado RF, Singla S. PMID: 33058734; PMCID: PMC7780991.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Development of a National Academic Boot Camp to Improve Fellowship Readiness. ATS Sch. 2020 Dec 22; 2(1):49-65. Drake MG, Shah NG, Lee M, Brady A, Connors GR, Clark BJ, Kritek PA, McCallister JW, Burkart KM, Pedraza I, Jamieson D, Ingram JL, Lynch L, Makani SS, Siegel-Gasiewski J, Larsson EM, Zemanick ET, Liptzin DR, Good R, Crotty Alexander LE. PMID: 33870323; PMCID: PMC8043273.
      View in: PubMed   Mentions:
    23. E-cigarettes and health risks: more to the flavor than just the name. Am J Physiol Lung Cell Mol Physiol. 2021 04 01; 320(4):L600-L614. Ween MP, Moshensky A, Thredgold L, Bastian NA, Hamon R, Badiei A, Nguyen PT, Herewane K, Jersmann H, Bojanowski CM, Shin J, Reynolds PN, Crotty Alexander LE, Hodge SJ. PMID: 33295836; PMCID: PMC8424560.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. Critical Care Education in a Pandemic through Tele-ICU. ATS Sch. 2020 Dec 03; 2(1):29-33. Leverone NA, Ramnath VR, Munce D, Raphelson JR, Ma J, Akuthota P, Tomaszewski C, Sell RE, Crotty Alexander LE, Akrami KM, Malhotra A. PMID: 33870321; PMCID: PMC8043279.
      View in: PubMed   Mentions: 2  
    25. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Chem Biol Interact. 2021 Jan 05; 333:109308. Alasmari F, Crotty Alexander LE, Hammad AM, Horton A, Alhaddad H, Schiefer IT, Shin J, Moshensky A, Sari Y. PMID: 33242460; PMCID: PMC7752837.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. Bleomycin-induced lung injury treated with venovenous extracorporeal membrane oxygenation (ECMO) and ultra-protective ventilator settings. BMJ Case Rep. 2020 Nov 23; 13(11). Odish MF, McGuire WC, Thistlethwaite P, Crotty Alexander LE. PMID: 33229479; PMCID: PMC7684647.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Vaping disrupts ventilation-perfusion matching in asymptomatic users. J Appl Physiol (1985). 2021 02 01; 130(2):308-317. Kizhakke Puliyakote AS, Elliott AR, Sá RC, Anderson KM, Crotty Alexander LE, Hopkins SR. PMID: 33180648; PMCID: PMC7948111.
      View in: PubMed   Mentions: 3     Fields:    
    28. Vaping and e-cigarette use. Mysterious lung manifestations and an epidemic. Curr Opin Immunol. 2020 10; 66:143-150. Casey AM, Muise ED, Crotty Alexander LE. PMID: 33186869; PMCID: PMC7755270.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Effects of 3-Month Exposure to E-Cigarette Aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice. Toxics. 2020 Oct 29; 8(4). Alhaddad H, Wong W, Sari AT, Crotty Alexander LE, Sari Y. PMID: 33137879; PMCID: PMC7712012.
      View in: PubMed   Mentions: 5  
    30. Vaping-related lung injury. Virchows Arch. 2021 Jan; 478(1):81-88. Smith ML, Gotway MB, Crotty Alexander LE, Hariri LP. PMID: 33106908; PMCID: PMC7590536.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Cigarette Smoke Exposure Promotes Virulence of Pseudomonas aeruginosa and Induces Resistance to Neutrophil Killing. Infect Immun. 2020 10 19; 88(11). Chien J, Hwang JH, Nilaad S, Masso-Silva JA, Jeong Ahn S, McEachern EK, Moshensky A, Byun MK, Crotty Alexander LE. PMID: 32868344; PMCID: PMC7573448.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. Effects of e-cigarettes and vaping devices on cardiac and pulmonary physiology. J Physiol. 2020 11; 598(22):5039-5062. Tsai M, Byun MK, Shin J, Crotty Alexander LE. PMID: 32975834.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    33. E-Cigarette or Vaping Product Use-associated Lung Injury: Developing a Research Agenda. An NIH Workshop Report. Am J Respir Crit Care Med. 2020 09 15; 202(6):795-802. Crotty Alexander LE, Ware LB, Calfee CS, Callahan SJ, Eissenberg T, Farver C, Goniewicz ML, Jaspers I, Kheradmand F, King TE, Meyer NJ, Mikheev VB, Shields PG, Shihadeh A, Strongin R, Tarran R. PMID: 32243764; PMCID: PMC7491408.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    34. Response. Chest. 2020 08; 158(2):836-837. Chapman DG, Larcombe AN, Bozier J, Chivers EK, Crotty Alexander LE, Ween MP. PMID: 32768076.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Reply: E-Cigarette, or Vaping, Product Use-associated Lung Injury: A Response to Perez and Crotty Alexander. Ann Am Thorac Soc. 2020 07; 17(7):908. Perez MF, Crotty Alexander LE. PMID: 32320261; PMCID: PMC7328184.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    36. Is Increased Sleep Responsible for Reductions in Myocardial Infarction During the COVID-19 Pandemic? Am J Cardiol. 2020 09 15; 131:128-130. Advani I, Gunge D, Banks S, Mehta S, Park K, Patel M, Malhotra A, Crotty Alexander LE. PMID: 32703526; PMCID: PMC7305870.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    37. Why Is Vaping Going Up in Flames? Ann Am Thorac Soc. 2020 05; 17(5):545-549. Perez MF, Crotty Alexander LE. PMID: 31944819; PMCID: PMC7263393.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    38. Reply to Letter to the Editor: "Comment on 'E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation'". Am J Physiol Cell Physiol. 2020 03 01; 318(3):C706. Crotty Alexander LE, Meier A. PMID: 32150454.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. The Evolving Landscape of e-Cigarettes: A Systematic Review of Recent Evidence. Chest. 2020 05; 157(5):1362-1390. Bozier J, Chivers EK, Chapman DG, Larcombe AN, Bastian NA, Masso-Silva JA, Byun MK, McDonald CF, Crotty Alexander LE, Ween MP. PMID: 32006591.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansPHPublic Health
    40. Use of Electronic Cigarettes with Conventional Tobacco Is Associated with Decreased Sleep Quality in Women. Am J Respir Crit Care Med. 2019 12 01; 200(11):1431-1434. Boddu SA, Bojanowski CM, Lam MT, Advani IN, Scholten EL, Sun X, Montgrain P, Malhotra A, Jain S, Alexander LEC. PMID: 31314572; PMCID: PMC6884046.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    41. E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation. Am J Physiol Cell Physiol. 2020 01 01; 318(1):C205-C214. Corriden R, Moshensky A, Bojanowski CM, Meier A, Chien J, Nelson RK, Crotty Alexander LE. PMID: 31664858; PMCID: PMC6985828.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    42. Design and Implementation of a Peer-Reviewed Medical Education Video Competition: The Best of American Thoracic Society Video Lecture Series. J Grad Med Educ. 2019 Oct; 11(5):592-596. Seam N, Richards JB, Kritek PA, Khemasuwan D, McCallister JW, Santhosh L, Prasad B, Bhargava S, Clay AS, Crotty Alexander LE. PMID: 31636831; PMCID: PMC6795340.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. ATS Health Alert-Vaping-associated Pulmonary Illness (VAPI). Am J Respir Crit Care Med. 2019 10 01; 200(7):P15-P16. Carlos WG, Crotty Alexander LE, Gross JE, Dela Cruz CS, Keller JM, Pasnick S, Jamil S. PMID: 31532698.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    44. Effects of Chronic Inhalation of Electronic Cigarette Vapor Containing Nicotine on Neurotransmitters in the Frontal Cortex and Striatum of C57BL/6 Mice. Front Pharmacol. 2019; 10:885. Alasmari F, Crotty Alexander LE, Hammad AM, Bojanowski CM, Moshensky A, Sari Y. PMID: 31456684; PMCID: PMC6699083.
      View in: PubMed   Mentions: 18  
    45. Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF. J Immunol. 2019 07 15; 203(2):329-337. Nelson RK, Brickner H, Panwar B, Ramírez-Suástegui C, Herrera-de la Mata S, Liu N, Diaz D, Alexander LEC, Ay F, Vijayanand P, Seumois G, Akuthota P. PMID: 31175163; PMCID: PMC6616007.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    46. Recommendations for the Appropriate Structure, Communication, and Investigation of Tobacco Harm Reduction Claims. An Official American Thoracic Society Policy Statement. Am J Respir Crit Care Med. 2018 10 15; 198(8):e90-e105. Leone FT, Carlsen KH, Chooljian D, Crotty Alexander LE, Detterbeck FC, Eakin MN, Evers-Casey S, Farber HJ, Folan P, Kathuria H, Latzka K, McDermott S, McGrath-Morrow S, Moazed F, Munzer A, Neptune E, Pakhale S, Sachs DPL, Samet J, Sufian B, Upson D. PMID: 30320525; PMCID: PMC6943880.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    47. Ventilator-Induced Kidney Injury: Are Novel Biomarkers the Key to Prevention? Nephron. 2018; 140(2):90-93. Hepokoski ML, Malhotra A, Singh P, Crotty Alexander LE. PMID: 29996132; PMCID: PMC6165693.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    48. Otolaryngology in Critical Care. Ann Am Thorac Soc. 2018 06; 15(6):643-654. Joshua J, Scholten E, Schaerer D, Mafee MF, Alexander TH, Crotty Alexander LE. PMID: 29565639; PMCID: PMC6207134.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. A computerized exposure system for animal models to optimize nicotine delivery into the brain through inhalation of electronic cigarette vapors or cigarette smoke. Saudi Pharm J. 2018 Jul; 26(5):622-628. Alasmari F, Crotty Alexander LE, Drummond CA, Sari Y. PMID: 29989025; PMCID: PMC6035328.
      View in: PubMed   Mentions: 10  
    50. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. PMID: 29384700; PMCID: PMC6032308.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimals
    51. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017 07 03; 77:1-8. Alasmari F, Crotty Alexander LE, Nelson JA, Schiefer IT, Breen E, Drummond CA, Sari Y. PMID: 28347687; PMCID: PMC5466499.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    52. Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 03; 176:94-99. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander LE. PMID: 28093362.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    53. Hypothesis: may e-cigarette smoking boost the allergic epidemic? Clin Transl Allergy. 2016; 6:40. Bousquet J, Bachert C, Alexander LC, Leone FT. PMID: 27891215; PMCID: PMC5111212.
      View in: PubMed   Mentions: 4  
    54. Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F654-F660. Hepokoski M, Englert JA, Baron RM, Crotty-Alexander LE, Fuster MM, Beitler JR, Malhotra A, Singh P. PMID: 28365585; PMCID: PMC5407070.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    55. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. Physiol Genomics. 2016 12 01; 48(12):950-960. Drummond CA, Crotty Alexander LE, Haller ST, Fan X, Xie JX, Kennedy DJ, Liu J, Yan Y, Hernandez DA, Mathew DP, Cooper CJ, Shapiro JI, Tian J. PMID: 27789733; PMCID: PMC5206391.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    56. Spontaneous Pneumothorax Complicating Chronic Hepatic Hydrothorax: Successful Treatment by Small Bore Chest Tube. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):e43-e45. Hepokoski M, Makani SS, Lerner AD, Crotty Alexander LE. PMID: 27764014.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. HIF2α-arginase axis is essential for the development of pulmonary hypertension. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8801-6. Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS. PMID: 27432976; PMCID: PMC4978263.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    58. Global state of tobacco use: summary from the American Thoracic Society International Conference 2016. J Thorac Dis. 2016 Jul; 8(Suppl 7):S582-5. Shin S, Crotty Alexander LE. PMID: 27606101; PMCID: PMC4990678.
      View in: PubMed   Mentions: 4  
    59. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J Mol Med (Berl). 2016 06; 94(6):667-79. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E, Mathew DP, Das S, Moshensky A, Bapat S, Pride DT, Ongkeko WM, Crotty Alexander LE. PMID: 26804311.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    60. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016 Jan; 52:58-65. Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander LE, Brumund KT, Wang-Rodriguez J, Ongkeko WM. PMID: 26547127; PMCID: PMC4891196.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    61. Inflammatory Diseases of the Lung Induced by Conventional Cigarette Smoke: A Review. Chest. 2015 Nov; 148(5):1307-1322. Crotty Alexander LE, Shin S, Hwang JH. PMID: 26135024.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    62. The Need for More E-Cigarette Data: A Call to Action. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):275-6. Crotty Alexander L, Fuster M, Montgrain P, Malhotra A. PMID: 26230232.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    63. Electronic cigarettes: the new face of nicotine delivery and addiction. J Thorac Dis. 2015 Aug; 7(8):E248-51. Crotty Alexander LE, Vyas A, Schraufnagel DE, Malhotra A. PMID: 26380791; PMCID: PMC4561260.
      View in: PubMed   Mentions: 13  
    64. The Civil Liberty of Smoking Cigarettes. Chest. 2015 Jul; 148(1):6-8. Crotty Alexander LE, Malhotra A. PMID: 26149548.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    65. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun. 2015 Jun; 83(6):2443-52. McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander LE. PMID: 25824841; PMCID: PMC4432760.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    66. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J Mol Med (Berl). 2014 Dec; 92(12):1305-17. Vega VL, Crotty Alexander LE, Charles W, Hwang JH, Nizet V, De Maio A. PMID: 25163764.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    67. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One. 2013; 8(12):e84481. Crotty Alexander LE, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V. PMID: 24386389; PMCID: PMC3873454.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    68. Epidermal deletion of HIF-2α stimulates wound closure. J Invest Dermatol. 2014 Mar; 134(3):801-808. Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS. PMID: 24037341; PMCID: PMC3877686.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    69. Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model. Clin Immunol. 2013 Apr; 147(1):27-37. Baek KJ, Cho JY, Rosenthal P, Alexander LEC, Nizet V, Broide DH. PMID: 23499929; PMCID: PMC3812068.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    70. Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. PMID: 23250618; PMCID: PMC3646920.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    71. Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications. Cell Stress Chaperones. 2011 Sep; 16(5):573-81. Vega VL, Charles W, Crotty Alexander LE, Alexander LE. PMID: 21626279; PMCID: PMC3156255.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    72. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010 Jan 05; 5(1):e8557. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. PMID: 20052280; PMCID: PMC2796718.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    73. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med (Berl). 2010 Apr; 88(4):371-81. Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Köckritz-Blickwede M, Nizet V. PMID: 19960175; PMCID: PMC2843839.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    74. Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. J Biol Chem. 2005 Jan 21; 280(3):1882-92. Laugel B, Boulter JM, Lissin N, Vuidepot A, Li Y, Gostick E, Crotty LE, Douek DC, Hemelaar J, Price DA, Jakobsen BK, Sewell AK. PMID: 15531581.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    75. Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. Clin Cancer Res. 2003 Sep 15; 9(11):4247-54. Heimberger AB, Crotty LE, Archer GE, Hess KR, Wikstrand CJ, Friedman AH, Friedman HS, Bigner DD, Sampson JH. PMID: 14519652.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    76. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003 Apr 01; 101(7):2711-20. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. PMID: 12433688.
      View in: PubMed   Mentions: 446     Fields:    Translation:HumansCells
    77. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery. 2002 Jan; 50(1):158-64; discussion 164-6. Heimberger AB, Archer GE, Crotty LE, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Sampson JH. PMID: 11844246.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    78. Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system. Cancer Immunol Immunother. 2002 Feb; 50(12):639-52. Wikstrand CJ, Cole VR, Crotty LE, Sampson JH, Bigner DD. PMID: 11862416.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    79. Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7503-8. Sampson JH, Crotty LE, Lee S, Archer GE, Ashley DM, Wikstrand CJ, Hale LP, Small C, Dranoff G, Friedman AH, Friedman HS, Bigner DD. PMID: 10852962; PMCID: PMC16575.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    80. Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma. J Neuroimmunol. 2000 Feb 01; 103(1):16-25. Heimberger AB, Crotty LE, Archer GE, McLendon RE, Friedman A, Dranoff G, Bigner DD, Sampson JH. PMID: 10674985.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCellsPHPublic Health
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