Mark Hepokoski

Title(s)Assistant Professor Of Clinical, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 14. Hepokoski ML, Odish MF, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, Jepsen K, Cutter G, Gillespie MN, Spragg RG, Sasik R, Ix JH. PMID: 35699291.
      View in: PubMed   Mentions:
    2. Correction to: Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 Patients: A Case Series and Review of the Literature. Clin Infect Dis. 2022 May 30; 74(10):1889-1890. Masso-Silva JA, Moshensky A, Lam MTY, Odish M, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott R, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Crotty Alexander LE. PMID: 35416961.
      View in: PubMed   Mentions:
    3. Mitochondria as mediators of systemic inflammation and organ cross talk in acute kidney injury. Am J Physiol Renal Physiol. 2022 Jun 01; 322(6):F589-F596. Hepokoski M, Singh P. PMID: 35379000.
      View in: PubMed   Mentions:
    4. Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature. Clin Infect Dis. 2022 02 11; 74(3):479-489. Masso-Silva JA, Moshensky A, Lam MTY, Odish MF, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott RK, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Crotty Alexander LE. PMID: 33988226; PMCID: PMC8241438.
      View in: PubMed   Mentions: 2     Fields:    
    5. Inpatient use of metformin and acarbose is associated with reduced mortality of COVID-19 patients with type 2 diabetes mellitus. Endocrinol Diabetes Metab. 2022 01; 5(1):e00301. Li J, Wei Q, McCowen KC, Xiong W, Liu J, Jiang W, Thomas RL, Hepokoski M, He M, Shyy JYJ, Malhotra A, Xiong N, Li WX. PMID: 34585841; PMCID: PMC8646242.
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    6. The State of Morning Report in the Current Healthcare Landscape: a National Survey of Internal Medicine Program Directors. J Gen Intern Med. 2021 Sep 28. Lessing JN, McGarry K, Schiffman F, Austin M, Hepokoski M, Keniston A, Tammaro D, Finn KM. PMID: 34585310; PMCID: PMC8477724.
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    7. Targeting Mitochondria and Metabolism in Acute Kidney Injury. J Clin Med. 2021 Sep 03; 10(17). Li Y, Hepokoski M, Gu W, Simonson T, Singh P. PMID: 34501442; PMCID: PMC8432487.
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    8. Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19. bioRxiv. 2021 Aug 24. Lam MTY, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. PMID: 34462742; PMCID: PMC8404884.
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    9. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circ Res. 2021 04 30; 128(9):1323-1326. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33784827; PMCID: PMC8091897.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    10. Inpatient Use of Metformin and Acarbose Is Associated with Reduced Mortality of COVID-19 Patients with Type 2 Diabetes Mellitus. Res Sq. 2021 Mar 26. Li W, Li J, Wei Q, McCowen K, Xiong W, Liu J, Jiang W, Thomas R, Hepokoski M, He M, Shyy J, Malhotra A, Xiong N. PMID: 33791691; PMCID: PMC8010742.
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    11. Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L821-L831. Hepokoski M, Wang J, Li K, Li Y, Gupta P, Mai T, Moshensky A, Alotaibi M, Crotty Alexander LE, Malhotra A, Singh P. PMID: 33565357; PMCID: PMC8174821.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. bioRxiv. 2020 Dec 04. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33300001; PMCID: PMC7724674.
      View in: PubMed   Mentions: 3  
    13. Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. Endocr Pract. 2020 Oct; 26(10):1166-1172. Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, Jiang W, Marin T, Thomas RL, He M, Gongol B, Hepokoski M, Yuan JX, Shyy JY, Xiong N, Malhotra A. PMID: 33471718; PMCID: PMC7834011.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. ACE2, Metformin, and COVID-19. iScience. 2020 Jul 31; 23(9):101425. Malhotra A, Hepokoski M, McCowen KC, Y-J Shyy J. PMID: 32818905; PMCID: PMC7452173.
      View in: PubMed   Mentions: 14  
    15. Mitochondrial transplantation: respiration rescue in respiratory failure. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L76-L77. Hepokoski M. PMID: 31774303.
      View in: PubMed   Mentions: Translation:AnimalsCells
    16. Can We DAMPen the Cross-Talk between the Lung and Kidney in the ICU? Am J Respir Crit Care Med. 2018 Nov 01; 198(9):1220-1222. Hepokoski ML, Bellinghausen AL, Bojanowski CM, Malhotra A. PMID: 30153048; PMCID: PMC6221576.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Ventilator-Induced Kidney Injury: Are Novel Biomarkers the Key to Prevention? Nephron. 2018; 140(2):90-93. Hepokoski ML, Malhotra A, Singh P, Crotty Alexander LE. PMID: 29996132; PMCID: PMC6165693.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Prone positioning in acute respiratory distress syndrome: why aren't we using it more? J Thorac Dis. 2018 Apr; 10(Suppl 9):S1020-S1024. Hepokoski ML, Odish M, Malhotra A. PMID: 29849212; PMCID: PMC5949405.
      View in: PubMed   Mentions: 5  
    19. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. PMID: 29384700; PMCID: PMC6032308.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    20. Renal Oxygenation and Hemodynamics in Kidney Injury. Nephron. 2017; 137(4):260-263. Bullen A, Liu ZZ, Hepokoski M, Li Y, Singh P. PMID: 28614837; PMCID: PMC5732093.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Update in Critical Care Medicine: Evidence Published in 2016. Ann Intern Med. 2017 04 04; 166(7):W20-W26. Hepokoski M, Malhotra A. PMID: 28358929; PMCID: PMC5483325.
      View in: PubMed   Mentions:    Fields:    
    22. Prediction of human core temperature rise and moisture loss in refuge alternatives for underground coal mines. Trans Soc Min Metall Explor Inc. 2017 Jan; 342:29-35. Klein M, Yantek DS, Hepokoski M, Yan L. PMID: 29545729; PMCID: PMC5849269.
      View in: PubMed   Mentions: 1  
    23. Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F654-F660. Hepokoski M, Englert JA, Baron RM, Crotty-Alexander LE, Fuster MM, Beitler JR, Malhotra A, Singh P. PMID: 28365585; PMCID: PMC5407070.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Spontaneous Pneumothorax Complicating Chronic Hepatic Hydrothorax: Successful Treatment by Small Bore Chest Tube. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):e43-e45. Hepokoski M, Makani SS, Lerner AD, Crotty Alexander LE. PMID: 27764014.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Mechanical ventilation in acute respiratory distress syndrome at ATS 2016: the search for a patient-specific strategy. J Thorac Dis. 2016 Jul; 8(Suppl 7):S550-2. Hepokoski M, Owens RL, Malhotra A, Beitler JR. PMID: 27606091; PMCID: PMC4990680.
      View in: PubMed   Mentions: 3  
    26. Mechanisms and implications of the link between sleep apnoea and chronic kidney disease. Respirology. 2016 May; 21(4):578-9. Hepokoski ML, Wali AR, Sarmiento KF. PMID: 27030604.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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