Mark Hepokoski

Title(s)	Associate Professor Of Clinical, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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E-cigarette-induced changes in cell stress and mitochondrial function. Free Radic Biol Med. 2025 Feb 16; 228:329-338. Chitteti R, Zuniga-Hertz JP, Masso-Silva JA, Shin J, Niesman I, Bojanowski CM, Kumar AJ, Hepokoski M, Crotty Alexander LE, Patel HH, Roth DM. PMID: 39756490.

View in: PubMed Mentions: Fields:
Bio Biochemistry Med Medicine (General)
Translation:Humans Cells
Human pulmonary microvascular endothelial cells respond to DAMPs from injured renal tubular cells. Pulm Circ. 2024 Jul; 14(3):e12379. DeWolf SE, Hawkes AA, Kurian SM, Gorial DE, Hepokoski ML, Almeida SS, Posner IR, McKay DB. PMID: 38962184; PMCID: PMC11220341.

View in: PubMed Mentions: 2
Bidirectional pressure: a mini review of ventilator-lung-kidney interactions. Front Physiol. 2024; 15:1428177. Kumar A, Epler K, DeWolf S, Barnes L, Hepokoski M. PMID: 38966229; PMCID: PMC11222611.

View in: PubMed Mentions:
Multicentre, randomised, double-blind, placebo-controlled, proof of concept study of LSALT peptide as prevention of acute respiratory distress syndrome and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19). BMJ Open. 2024 03 15; 14(3):e076142. Somayaji R, Luke DR, Lau A, Guner R, Tabak OF, Hepokoski M, Gardetto N, Conrad SA, Kumar SD, Ghosh K, Robbins SM, Senger DL, Sun D, Lim RKS, Liu J, Eser F, Karaali R, Tremblay A, Muruve D. PMID: 38490660; PMCID: PMC10946381.

View in: PubMed Mentions: 1 Fields:
Med Medicine (General)
Translation:Humans Cells
Energy Metabolism Dysregulation in Chronic Kidney Disease. Kidney360. 2023 08 01; 4(8):1080-1094. Li Y, Gu W, Hepokoski M, Pham H, Tham R, Kim YC, Simonson TS, Singh P. PMID: 37222594; PMCID: PMC10476685.

View in: PubMed Mentions: 8 Fields:
Nep Nephrology
Translation:Humans
Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients. Cell Rep Med. 2023 02 21; 4(2):100935. Lam MTY, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. PMID: 36758547; PMCID: PMC9874047.

View in: PubMed Mentions: 7 Fields:
Med Medicine (General)
Translation:Humans Cells
Very Low Driving-Pressure Ventilation in Patients With COVID-19 Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation: A Physiologic Study. J Cardiothorac Vasc Anesth. 2023 03; 37(3):423-431. Odish M, Pollema T, Meier A, Hepokoski M, Yi C, Spragg R, Patel HH, Alexander LEC, Sun XS, Jain S, Simonson TS, Malhotra A, Owens RL. PMID: 36567221; PMCID: PMC9701579.

View in: PubMed Mentions: Fields:
Ane Anesthesiology Car Cardiology Pul Pulmonary Medicine
Translation:Humans
Association Between Acute Kidney Injury During Invasive Mechanical Ventilation and ICU Outcomes and Respiratory System Mechanics. Crit Care Explor. 2022 Jul; 4(7):e0720. Vemuri SV, Rolfsen ML, Sykes AV, Takiar PG, Leonard AJ, Malhotra A, Spragg RG, Macedo E, Hepokoski ML. PMID: 35782295; PMCID: PMC9246080.

View in: PubMed Mentions: 8
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L84-L92. Hepokoski ML, Odish M, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, Jepsen K, Cutter G, Gillespie MN, Spragg RG, Sasik R, Ix JH. PMID: 35699291; PMCID: PMC9273271.

View in: PubMed Mentions: 8 Fields:
Cel Cell Biology Mol Molecular Biology Phy Physiology Pul Pulmonary Medicine
Translation:Humans
Correction to: Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 Patients: A Case Series and Review of the Literature. Clin Infect Dis. 2022 May 30; 74(10):1889-1890. Masso-Silva JA, Moshensky A, Lam MTY, Odish M, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott R, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Crotty Alexander LE. PMID: 35416961; PMCID: PMC9327099.

View in: PubMed Mentions: 5 Fields:
Com Communicable Diseases
Mitochondria as mediators of systemic inflammation and organ cross talk in acute kidney injury. Am J Physiol Renal Physiol. 2022 06 01; 322(6):F589-F596. Hepokoski M, Singh P. PMID: 35379000; PMCID: PMC9054254.

View in: PubMed Mentions: 9 Fields:
Nep Nephrology Phy Physiology
Translation:Humans Cells
Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature. Clin Infect Dis. 2022 02 11; 74(3):479-489. Masso-Silva JA, Moshensky A, Lam MTY, Odish MF, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott RK, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Crotty Alexander LE. PMID: 33988226; PMCID: PMC8241438.

View in: PubMed Mentions: 64 Fields:
Com Communicable Diseases
Translation:Humans Cells
Inpatient use of metformin and acarbose is associated with reduced mortality of COVID-19 patients with type 2 diabetes mellitus. Endocrinol Diabetes Metab. 2022 01; 5(1):e00301. Li J, Wei Q, McCowen KC, Xiong W, Liu J, Jiang W, Thomas RL, Hepokoski M, He M, Shyy JYJ, Malhotra A, Xiong N, Li WX. PMID: 34585841; PMCID: PMC8646242.

View in: PubMed Mentions: 14 Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells
The State of Morning Report in the Current Healthcare Landscape: a National Survey of Internal Medicine Program Directors. J Gen Intern Med. 2022 05; 37(7):1665-1672. Lessing JN, McGarry K, Schiffman F, Austin M, Hepokoski M, Keniston A, Tammaro D, Finn KM. PMID: 34585310; PMCID: PMC8477724.

View in: PubMed Mentions: 5 Fields:
Int Internal Medicine
Translation:Humans
Targeting Mitochondria and Metabolism in Acute Kidney Injury. J Clin Med. 2021 Sep 03; 10(17). Li Y, Hepokoski M, Gu W, Simonson T, Singh P. PMID: 34501442; PMCID: PMC8432487.

View in: PubMed Mentions: 13
Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19. bioRxiv. 2021 Aug 24. Lam MTY, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. PMID: 34462742; PMCID: PMC8404884.

View in: PubMed Mentions: 3
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circ Res. 2021 04 30; 128(9):1323-1326. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33784827; PMCID: PMC8091897.

View in: PubMed Mentions: 239 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals Cells
Inpatient Use of Metformin and Acarbose Is Associated with Reduced Mortality of COVID-19 Patients with Type 2 Diabetes Mellitus. Res Sq. 2021 Mar 26. Li W, Li J, Wei Q, McCowen K, Xiong W, Liu J, Jiang W, Thomas R, Hepokoski M, He M, Shyy J, Malhotra A, Xiong N. PMID: 33791691; PMCID: PMC8010742.

View in: PubMed Mentions:
Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L821-L831. Hepokoski M, Wang J, Li K, Li Y, Gupta P, Mai T, Moshensky A, Alotaibi M, Crotty Alexander LE, Malhotra A, Singh P. PMID: 33565357; PMCID: PMC8174821.

View in: PubMed Mentions: 29 Fields:
Cel Cell Biology Mol Molecular Biology Phy Physiology Pul Pulmonary Medicine
Translation:Animals Cells
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. bioRxiv. 2020 Dec 04. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. PMID: 33300001; PMCID: PMC7724674.

View in: PubMed Mentions: 4
Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. Endocr Pract. 2020 Oct; 26(10):1166-1172. Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, Jiang W, Marin T, Thomas RL, He M, Gongol B, Hepokoski M, Yuan JX, Shyy JY, Xiong N, Malhotra A. PMID: 33471718; PMCID: PMC7834011.

View in: PubMed Mentions: 22 Fields:
End Endocrinology
Translation:Humans Cells
ACE2, Metformin, and COVID-19. iScience. 2020 Jul 31; 23(9):101425. Malhotra A, Hepokoski M, McCowen KC, Y-J Shyy J. PMID: 32818905; PMCID: PMC7452173.

View in: PubMed Mentions: 34
Mitochondrial transplantation: respiration rescue in respiratory failure. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L76-L77. Hepokoski M. PMID: 31774303.

View in: PubMed Mentions: Fields:
Cel Cell Biology Mol Molecular Biology Phy Physiology Pul Pulmonary Medicine
Translation:Animals Cells
Can We DAMPen the Cross-Talk between the Lung and Kidney in the ICU? Am J Respir Crit Care Med. 2018 Nov 01; 198(9):1220-1222. Hepokoski ML, Bellinghausen AL, Bojanowski CM, Malhotra A. PMID: 30153048; PMCID: PMC6221576.

View in: PubMed Mentions: 4 Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans
Ventilator-Induced Kidney Injury: Are Novel Biomarkers the Key to Prevention? Nephron. 2018; 140(2):90-93. Hepokoski ML, Malhotra A, Singh P, Crotty Alexander LE. PMID: 29996132; PMCID: PMC6165693.

View in: PubMed Mentions: 20 Fields:
Nep Nephrology
Translation:Humans
Prone positioning in acute respiratory distress syndrome: why aren't we using it more? J Thorac Dis. 2018 Apr; 10(Suppl 9):S1020-S1024. Hepokoski ML, Odish M, Malhotra A. PMID: 29849212; PMCID: PMC5949405.

View in: PubMed Mentions: 7
Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. PMID: 29384700; PMCID: PMC6032308.

View in: PubMed Mentions: 101 Fields:
Phy Physiology
Translation:Humans Animals
Renal Oxygenation and Hemodynamics in Kidney Injury. Nephron. 2017; 137(4):260-263. Bullen A, Liu ZZ, Hepokoski M, Li Y, Singh P. PMID: 28614837; PMCID: PMC5732093.

View in: PubMed Mentions: 21 Fields:
Nep Nephrology
Translation:Humans
Update in Critical Care Medicine: Evidence Published in 2016. Ann Intern Med. 2017 04 04; 166(7):W20-W26. Hepokoski M, Malhotra A. PMID: 28358929; PMCID: PMC5483325.

View in: PubMed Mentions: Fields:
Int Internal Medicine
Prediction of human core temperature rise and moisture loss in refuge alternatives for underground coal mines. Trans Soc Min Metall Explor Inc. 2017 Jan; 342:29-35. Klein M, Yantek DS, Hepokoski M, Yan L. PMID: 29545729; PMCID: PMC5849269.

View in: PubMed Mentions:
Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F654-F660. Hepokoski M, Englert JA, Baron RM, Crotty-Alexander LE, Fuster MM, Beitler JR, Malhotra A, Singh P. PMID: 28365585; PMCID: PMC5407070.

View in: PubMed Mentions: 34 Fields:
Nep Nephrology Phy Physiology
Translation:Animals Cells
Spontaneous Pneumothorax Complicating Chronic Hepatic Hydrothorax: Successful Treatment by Small Bore Chest Tube. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):e43-e45. Hepokoski M, Makani SS, Lerner AD, Crotty Alexander LE. PMID: 27764014.

View in: PubMed Mentions: Fields:
Pul Pulmonary Medicine
Translation:Humans
Mechanical ventilation in acute respiratory distress syndrome at ATS 2016: the search for a patient-specific strategy. J Thorac Dis. 2016 Jul; 8(Suppl 7):S550-2. Hepokoski M, Owens RL, Malhotra A, Beitler JR. PMID: 27606091; PMCID: PMC4990680.

View in: PubMed Mentions: 4
Mechanisms and implications of the link between sleep apnoea and chronic kidney disease. Respirology. 2016 May; 21(4):578-9. Hepokoski ML, Wali AR, Sarmiento KF. PMID: 27030604.

View in: PubMed Mentions: Fields:
Pul Pulmonary Medicine
Translation:Humans