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Susan Hopkins

Title(s)Professor In Residence, Radiology
SchoolHealth Sciences
Phone858-534-2680
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    Collapse Research 
    Collapse Research Activities and Funding
    Imaging Hypoxic Pulmonary Vasoconstriction in the Aging Lung with Proton MRI
    NIH/NHLBI R01HL129990Aug 15, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Imaging Blood Flow, Ventilation, and Density Interactions
    NIH/NHLBI R01HL119201Apr 1, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Imaging regional transit time and pulmonary vascular resistance in the human lung
    NIH/NHLBI R21HL122753Dec 1, 2014 - Nov 30, 2016
    Role: Principal Investigator
    Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRI
    NIH/NHLBI R21HL118539Aug 15, 2013 - May 31, 2015
    Role: Principal Investigator
    Lung Perfusion Heterogeneity and Mechanisms of Edema
    NIH/NHLBI R01HL081171Apr 1, 2006 - Mar 31, 2012
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tedjasaputra V, Sá RC, Anderson KM, Prisk GK, Hopkins SR. Heavy upright exercise increases ventilation-perfusion mismatch in the basal lung: indirect evidence for interstitial pulmonary edema. J Appl Physiol (1985). 2019 Jun 27. PMID: 31246558.
      View in: PubMed
    2. Asadi AK, Sá RC, Arai TJ, Theilmann RJ, Hopkins SR, Buxton RB, Prisk GK. Regional pulmonary perfusion patterns in humans are not significantly altered by inspiratory hypercapnia. J Appl Physiol (1985). 2019 Jun 06. PMID: 31169470.
      View in: PubMed
    3. Sá RC, Henderson AC, Simonson T, Arai TJ, Wagner H, Theilmann RJ, Wagner PD, Prisk GK, Hopkins SR. Measurement of the distribution of ventilation-perfusion ratios in the human lung with proton MRI: comparison with the multiple inert-gas elimination technique. J Appl Physiol (1985). 2017 Jul 01; 123(1):136-146. PMID: 28280105.
      View in: PubMed
    4. Hopkins SR, Elliott AR, Prisk GK, Darquenne C. Ventilation heterogeneity measured by multiple breath inert gas testing is not affected by inspired oxygen concentration in healthy humans. J Appl Physiol (1985). 2017 Jun 01; 122(6):1379-1387. PMID: 28280107.
      View in: PubMed
    5. Patz MD, Sá RC, Darquenne C, Elliott AR, Asadi AK, Theilmann RJ, Dubowitz DJ, Swenson ER, Prisk GK, Hopkins SR. Susceptibility to high-altitude pulmonary edema is associated with a more uniform distribution of regional specific ventilation. J Appl Physiol (1985). 2017 Apr 01; 122(4):844-852. PMID: 28057815.
      View in: PubMed
    6. Hopkins SR, Wagner PD. Case Studies in Physiology: The Case of the Giant Giraffe. J Appl Physiol (1985). 2016 12; 121(6):1379-1380. PMID: 27742805.
      View in: PubMed
    7. Levin DL, Schiebler ML, Hopkins SR. Physiology for the pulmonary functional imager. Eur J Radiol. 2017 Jan; 86:308-312. PMID: 27707586.
      View in: PubMed
    8. Arai TJ, Theilmann RJ, Sá RC, Villongco MT, Hopkins SR. The effect of lung deformation on the spatial distribution of pulmonary blood flow. J Physiol. 2016 11 01; 594(21):6333-6347. PMID: 27273807.
      View in: PubMed
    9. Basaran KE, Villongco M, Ho B, Ellis E, Zarndt R, Antonova J, Hopkins SR, Powell FL. Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans. PLoS One. 2016; 11(1):e0146087. PMID: 26726885; PMCID: PMC4699648.
      View in: PubMed, PubMed Central
    10. Walker SC, Asadi AK, Hopkins SR, Buxton RB, Prisk GK. A statistical clustering approach to discriminating perfusion from conduit vessel signal contributions in a pulmonary ASL MR image. NMR Biomed. 2015 Sep; 28(9):1117-24. PMID: 26182890; PMCID: PMC4537803.
      View in: PubMed, PubMed Central
    11. Asadi AK, Sá RC, Kim NH, Theilmann RJ, Hopkins SR, Buxton RB, Prisk GK. Inhaled nitric oxide alters the distribution of blood flow in the healthy human lung, suggesting active hypoxic pulmonary vasoconstriction in normoxia. J Appl Physiol (1985). 2015 Feb 01; 118(3):331-43. PMID: 25429099; PMCID: PMC4312852.
      View in: PubMed, PubMed Central
    12. Miller GW, Mugler JP, Sá RC, Altes TA, Prisk GK, Hopkins SR. Advances in functional and structural imaging of the human lung using proton MRI. NMR Biomed. 2014 Dec; 27(12):1542-56. PMID: 24990096; PMCID: PMC4515033.
      View in: PubMed, PubMed Central
    13. Sá RC, Asadi AK, Theilmann RJ, Hopkins SR, Prisk GK, Darquenne C. Validating the distribution of specific ventilation in healthy humans measured using proton MR imaging. J Appl Physiol (1985). 2014 Apr 15; 116(8):1048-56. PMID: 24505099; PMCID: PMC4035784.
      View in: PubMed, PubMed Central
    14. Froehle AW, Hopkins SR, Natarajan L, Schoeninger MJ. Moderate to high levels of exercise are associated with higher resting energy expenditure in community-dwelling postmenopausal women. Appl Physiol Nutr Metab. 2013 Nov; 38(11):1147-53. PMID: 24053522; PMCID: PMC3865986.
      View in: PubMed, PubMed Central
    15. Tedjasaputra V, Sá RC, Arai TJ, Holverda S, Theilmann RJ, Chen WT, Wagner PD, Davis CK, Kim Prisk G, Hopkins SR. The heterogeneity of regional specific ventilation is unchanged following heavy exercise in athletes. J Appl Physiol (1985). 2013 Jul 01; 115(1):126-35. PMID: 23640585; PMCID: PMC3727009.
      View in: PubMed, PubMed Central
    16. Henderson AC, Sá RC, Theilmann RJ, Buxton RB, Prisk GK, Hopkins SR. The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung. J Appl Physiol (1985). 2013 Aug 01; 115(3):313-24. PMID: 23620488; PMCID: PMC3743008.
      View in: PubMed, PubMed Central
    17. Stickland MK, Lindinger MI, Olfert IM, Heigenhauser GJ, Hopkins SR. Pulmonary gas exchange and acid-base balance during exercise. Compr Physiol. 2013 Apr; 3(2):693-739. PMID: 23720327.
      View in: PubMed
    18. Asadi AK, Cronin MV, Sá RC, Theilmann RJ, Holverda S, Hopkins SR, Buxton RB, Prisk GK. Spatial-temporal dynamics of pulmonary blood flow in the healthy human lung in response to altered FI(O2). J Appl Physiol (1985). 2013 Jan 01; 114(1):107-18. PMID: 23104691; PMCID: PMC3544514.
      View in: PubMed, PubMed Central
    19. Liang CL, Ances BM, Perthen JE, Moradi F, Liau J, Buracas GT, Hopkins SR, Buxton RB. Luminance contrast of a visual stimulus modulates the BOLD response more than the cerebral blood flow response in the human brain. Neuroimage. 2013 Jan 01; 64:104-11. PMID: 22963855; PMCID: PMC3545642.
      View in: PubMed, PubMed Central
    20. Hopkins SR, Wielpütz MO, Kauczor HU. Imaging lung perfusion. J Appl Physiol (1985). 2012 Jul; 113(2):328-39. PMID: 22604884; PMCID: PMC3404706.
      View in: PubMed, PubMed Central
    21. Arai TJ, Villongco CT, Villongco MT, Hopkins SR, Theilmann RJ. Affine transformation registers small scale lung deformation. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:5298-301. PMID: 23367125.
      View in: PubMed
    22. Casey DP, Imray CH, Wilson MH, Flouris AD, Carrillo AE, Tedjasaputra V, Hopkins SR, Birchard GF, Billat V, West JB, Vagula MC, Nelatury C, Bennet L, Gasier HG, Gunga HC, Egginton S, Kumar P. Comments on point: counterpoint: high altitude is/is not for the birds! J Appl Physiol (1985). 2011 Nov; 111(5):1520-4. PMID: 22096211.
      View in: PubMed
    23. Holverda S, Theilmann RJ, Sá RC, Arai TJ, Hall ET, Dubowitz DJ, Prisk GK, Hopkins SR. Measuring lung water: ex vivo validation of multi-image gradient echo MRI. J Magn Reson Imaging. 2011 Jul; 34(1):220-4. PMID: 21698711; PMCID: PMC3122154.
      View in: PubMed, PubMed Central
    24. Arai TJ, Prisk GK, Holverda S, Sá RC, Theilmann RJ, Henderson AC, Cronin MV, Buxton RB, Hopkins SR. Magnetic resonance imaging quantification of pulmonary perfusion using calibrated arterial spin labeling. J Vis Exp. 2011 May 30; (51). PMID: 21673635; PMCID: PMC3197117.
      View in: PubMed, PubMed Central
    25. Hopkins SR, Prisk GK. Lung perfusion measured using magnetic resonance imaging: New tools for physiological insights into the pulmonary circulation. J Magn Reson Imaging. 2010 Dec; 32(6):1287-301. PMID: 21105135; PMCID: PMC3359842.
      View in: PubMed, PubMed Central
    26. Sá RC, Cronin MV, Henderson AC, Holverda S, Theilmann RJ, Arai TJ, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. Vertical distribution of specific ventilation in normal supine humans measured by oxygen-enhanced proton MRI. J Appl Physiol (1985). 2010 Dec; 109(6):1950-9. PMID: 20930129; PMCID: PMC3006418.
      View in: PubMed, PubMed Central
    27. Hopkins SR, Arai TJ, Henderson AC, Levin DL, Buxton RB, Kim Prisk G. Lung volume does not alter the distribution of pulmonary perfusion in dependent lung in supine humans. J Physiol. 2010 Dec 01; 588(Pt 23):4759-68. PMID: 20921195; PMCID: PMC3010144.
      View in: PubMed, PubMed Central
    28. Hopkins SR. Point: Pulmonary edema does occur in human athletes performing heavy sea-level exercise. J Appl Physiol (1985). 2010 Oct; 109(4):1270-2. PMID: 20056844; PMCID: PMC3774213.
      View in: PubMed, PubMed Central
    29. Henderson AC, Prisk GK, Levin DL, Hopkins SR, Buxton RB. Characterizing pulmonary blood flow distribution measured using arterial spin labeling. NMR Biomed. 2009 Dec; 22(10):1025-35. PMID: 19492332; PMCID: PMC2836845.
      View in: PubMed, PubMed Central
    30. Prisk GK, Olfert IM, Arai TJ, Wagner PD, Hopkins SR. Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lung. J Appl Physiol (1985). 2010 Jan; 108(1):53-9. PMID: 19910335; PMCID: PMC2885074.
      View in: PubMed, PubMed Central
    31. Hopkins SR, Olfert IM, Wagner PD. Last Word on Point:Counterpoint: Exercise-induced intrapulmonary shunting is imaginary vs. real. J Appl Physiol (1985). 2009 Sep; 107(3):1002. PMID: 19713436; PMCID: PMC4073924.
      View in: PubMed, PubMed Central
    32. Theilmann RJ, Arai TJ, Samiee A, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. Quantitative MRI measurement of lung density must account for the change in T(2) (*) with lung inflation. J Magn Reson Imaging. 2009 Sep; 30(3):527-34. PMID: 19630079; PMCID: PMC3354915.
      View in: PubMed, PubMed Central
    33. Dubowitz DJ, Dyer EA, Theilmann RJ, Buxton RB, Hopkins SR. Early brain swelling in acute hypoxia. J Appl Physiol (1985). 2009 Jul; 107(1):244-52. PMID: 19423837.
      View in: PubMed
    34. Hopkins SR, Olfert IM, Wagner PD. Point: Exercise-induced intrapulmonary shunting is imaginary. J Appl Physiol (1985). 2009 Sep; 107(3):993-4. PMID: 19023012; PMCID: PMC2756005.
      View in: PubMed, PubMed Central
    35. Hopkins SR, Prisk GK. Point:Counterpoint: Gravity is/is not the major factor determining the distribution of blood flow in the human lung. J Appl Physiol (1985). 2008 May; 104(5):1537-8. PMID: 18504813.
      View in: PubMed
    36. Dyer EA, Hopkins SR, Perthen JE, Buxton RB, Dubowitz DJ. Regional cerebral blood flow during acute hypoxia in individuals susceptible to acute mountain sickness. Respir Physiol Neurobiol. 2008 Feb 29; 160(3):267-76. PMID: 18088570; PMCID: PMC2387187.
      View in: PubMed, PubMed Central
    37. Hopkins SR, Kleinsasser A, Bernard S, Loeckinger A, Falor E, Neradilek B, Polissar NL, Hlastala MP. Hypoxia has a greater effect than exercise on the redistribution of pulmonary blood flow in swine. J Appl Physiol (1985). 2007 Dec; 103(6):2112-9. PMID: 17872407.
      View in: PubMed
    38. Prisk GK, Yamada K, Henderson AC, Arai TJ, Levin DL, Buxton RB, Hopkins SR. Pulmonary perfusion in the prone and supine postures in the normal human lung. J Appl Physiol (1985). 2007 Sep; 103(3):883-94. PMID: 17569767; PMCID: PMC2399900.
      View in: PubMed, PubMed Central
    39. Kleinsasser A, Olfert IM, Loeckinger A, Prisk GK, Hopkins SR, Wagner PD. Tidal volume dependency of gas exchange in bronchoconstricted pig lungs. J Appl Physiol (1985). 2007 Jul; 103(1):148-55. PMID: 17395763.
      View in: PubMed
    40. Hopkins SR, Henderson AC, Levin DL, Yamada K, Arai T, Buxton RB, Prisk GK. Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect. J Appl Physiol (1985). 2007 Jul; 103(1):240-8. PMID: 17395757; PMCID: PMC2399899.
      View in: PubMed, PubMed Central
    41. Levin DL, Buxton RB, Spiess JP, Arai T, Balouch J, Hopkins SR. Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging. J Appl Physiol (1985). 2007 May; 102(5):2064-70. PMID: 17303711.
      View in: PubMed
    42. Jonk AM, van den Berg IP, Olfert IM, Wray DW, Arai T, Hopkins SR, Wagner PD. Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise. J Physiol. 2007 Mar 15; 579(Pt 3):909-21. PMID: 17218362; PMCID: PMC2151360.
      View in: PubMed, PubMed Central
    43. Hopkins SR, Levin DL, Emami K, Kadlecek S, Yu J, Ishii M, Rizi RR. Advances in magnetic resonance imaging of lung physiology. J Appl Physiol (1985). 2007 Mar; 102(3):1244-54. PMID: 17158249.
      View in: PubMed
    44. Balouch J, Olfert IM, Wagner PD, Hopkins SR. The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Respir Physiol Neurobiol. 2007 Feb 15; 155(2):177-83. PMID: 16714151.
      View in: PubMed
    45. Henderson AC, Levin DL, Hopkins SR, Olfert IM, Buxton RB, Prisk GK. Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow. J Appl Physiol (1985). 2006 Aug; 101(2):583-9. PMID: 16601308; PMCID: PMC3373314.
      View in: PubMed, PubMed Central
    46. Hopkins SR. Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and pulmonary diffusion limitation. Adv Exp Med Biol. 2006; 588:17-30. PMID: 17089876.
      View in: PubMed
    47. Hopkins SR, Levin DL. Heterogeneous pulmonary blood flow in response to hypoxia: a risk factor for high altitude pulmonary edema? Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):217-28. PMID: 16377263.
      View in: PubMed
    48. Hopkins SR. The lung at maximal exercise: insights from comparative physiology. Clin Chest Med. 2005 Sep; 26(3):459-68, vi. PMID: 16140138.
      View in: PubMed
    49. Hopkins SR, Garg J, Bolar DS, Balouch J, Levin DL. Pulmonary blood flow heterogeneity during hypoxia and high-altitude pulmonary edema. Am J Respir Crit Care Med. 2005 Jan 01; 171(1):83-7. PMID: 15486339.
      View in: PubMed
    50. Hopkins SR. Functional magnetic resonance imaging of the lung: a physiological perspective. J Thorac Imaging. 2004 Oct; 19(4):228-34. PMID: 15502609.
      View in: PubMed
    51. Hupperets MD, Hopkins SR, Pronk MG, Tiemessen IJ, Garcia N, Wagner PD, Powell FL. Increased hypoxic ventilatory response during 8 weeks at 3800 m altitude. Respir Physiol Neurobiol. 2004 Sep 15; 142(2-3):145-52. PMID: 15450476.
      View in: PubMed
    52. Hopkins SR, Harms CA. Gender and pulmonary gas exchange during exercise. Exerc Sport Sci Rev. 2004 Apr; 32(2):50-6. PMID: 15064648.
      View in: PubMed
    53. Powell FL, Hopkins SR. Comparative physiology of lung complexity: implications for gas exchange. News Physiol Sci. 2004 Apr; 19:55-60. PMID: 15016903.
      View in: PubMed
    54. Olfert IM, Balouch J, Kleinsasser A, Knapp A, Wagner H, Wagner PD, Hopkins SR. Does gender affect human pulmonary gas exchange during exercise? J Physiol. 2004 Jun 01; 557(Pt 2):529-41. PMID: 14990677; PMCID: PMC1665094.
      View in: PubMed, PubMed Central
    55. Hopkins SR, Bogaard HJ, Niizeki K, Yamaya Y, Ziegler MG, Wagner PD. Beta-adrenergic or parasympathetic inhibition, heart rate and cardiac output during normoxic and acute hypoxic exercise in humans. J Physiol. 2003 Jul 15; 550(Pt 2):605-16. PMID: 12766243; PMCID: PMC2343040.
      View in: PubMed, PubMed Central
    56. Pronk M, Tiemessen I, Hupperets MD, Kennedy BP, Powell FL, Hopkins SR, Wagner PD. Persistence of the lactate paradox over 8 weeks at 3,800 m. High Alt Med Biol. 2003; 4(4):431-43. PMID: 14672546.
      View in: PubMed
    57. Kleinsasser A, Levin DL, Loeckinger A, Hopkins SR. A pig model of high altitude pulmonary edema. High Alt Med Biol. 2003; 4(4):465-74. PMID: 14672549.
      View in: PubMed
    58. Bao X, Kennedy BP, Hopkins SR, Bogaard HJ, Wagner PD, Ziegler MG. Human autonomic activity and its response to acute oxygen supplement after high altitude acclimatization. Auton Neurosci. 2002 Nov 29; 102(1-2):54-9. PMID: 12492136.
      View in: PubMed
    59. Bogaard HJ, Hopkins SR, Yamaya Y, Niizeki K, Ziegler MG, Wagner PD. Role of the autonomic nervous system in the reduced maximal cardiac output at altitude. J Appl Physiol (1985). 2002 Jul; 93(1):271-9. PMID: 12070214.
      View in: PubMed
    60. Yamaya Y, Bogaard HJ, Wagner PD, Niizeki K, Hopkins SR. Validity of pulse oximetry during maximal exercise in normoxia, hypoxia, and hyperoxia. J Appl Physiol (1985). 2002 Jan; 92(1):162-8. PMID: 11744656.
      View in: PubMed
    61. Hopkins SR, Barker RC, Brutsaert TD, Gavin TP, Entin P, Olfert IM, Veisel S, Wagner PD. Pulmonary gas exchange during exercise in women: effects of exercise type and work increment. J Appl Physiol (1985). 2000 Aug; 89(2):721-30. PMID: 10926659.
      View in: PubMed
    62. Hopkins SR, Gavin TP, Siafakas NM, Haseler LJ, Olfert IM, Wagner H, Wagner PD. Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes. J Appl Physiol (1985). 1998 Oct; 85(4):1523-32. PMID: 9760350.
      View in: PubMed
    63. Hopkins SR, Bayly WM, Slocombe RF, Wagner H, Wagner PD. Effect of prolonged heavy exercise on pulmonary gas exchange in horses. J Appl Physiol (1985). 1998 May; 84(5):1723-30. PMID: 9572823.
      View in: PubMed
    64. Hopkins SR, Schoene RB, Henderson WR, Spragg RG, West JB. Sustained submaximal exercise does not alter the integrity of the lung blood-gas barrier in elite athletes. J Appl Physiol (1985). 1998 Apr; 84(4):1185-9. PMID: 9516183.
      View in: PubMed
    65. Hopkins SR, Wang T, Hicks JW. The effect of altering pulmonary blood flow on pulmonary gas exchange in the turtle Trachemys (Pseudemys) scripta. J Exp Biol. 1996 Oct; 199(Pt 10):2207-14. PMID: 8896364.
      View in: PubMed
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