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Praveen Akuthota

Title(s)Associate Clinical Professor, Medicine
SchoolHealth Sciences
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    Dr. Akuthota’s research efforts range from basic scientific investigations of human eosinophil biology and eosinophilic inflammation to clinical and translational efforts in asthma and eosinophilic pulmonary disease. He is the corresponding Principal Investigator for the UCSD Clinical Center in the National Heart, Lung, and Blood Institute’s PrecISE Network that will be studying precision interventions in severe asthma. He is a co-investigator on a study published in the New England Journal of Medicine showing the efficacy of anti-IL-5 therapy in the treatment of the eosinophilic disease EGPA (Churg Strauss syndrome). His research group is involved in other multicenter studies in eosinophilic disease and asthma. Basic science investigations from Dr. Akuthota focus on ex vivo studies of human eosinophils and include published work studying eosinophil trafficking and work studying microparticle release by eosinophils. He has written several reviews and chapters discussing eosinophil immunobiology and clinical considerations in eosinophilic diseases. Dr. Akuthota is an At-Large Member of the Board of Directors of the International Eosinophil Society (http://www.eosinophil-society.org/).

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    Collapse Research Activities and Funding
    San Diego Team Asthma Management using Phenotypes (STAMP)
    NIH/NHLBI UG1HL139117Sep 23, 2017 - Jun 30, 2023
    Role: Principal Investigator
    CC Chemokine-Mediated Differential Immunoregulation by Human Eosinophils
    NIH/NHLBI K08HL116429Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Tetraspanins in Asthma and Eosinophilic Lung Disease
    NIH/NIAID F32AI081513Jul 17, 2009 - Jul 16, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Akuthota P, Neves JS, Ueki S. Editorial: Severe Eosinophilic Disorders: Mechanisms and Clinical Management. Front Immunol. 2019; 10:2118. PMID: 31552048.
      View in: PubMed
    2. Nelson RK, Brickner H, Panwar B, Ramírez-Suástegui C, Herrera-de la Mata S, Liu N, Diaz D, Alexander LEC, Ay F, Vijayanand P, Seumois G, Akuthota P. Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common ß-Chain Cytokines IL-5 and GM-CSF. J Immunol. 2019 Jul 15; 203(2):329-337. PMID: 31175163.
      View in: PubMed
    3. Kurten RC, Rawson R, Shoda T, Duong LD, Adejumobi D, Levy R, Newbury RO, Rothenberg ME, Akuthota P, Wright BL, Dohil R, Jones SM, Aceves SS. Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. Sci Rep. 2019 Apr 17; 9(1):6206. PMID: 30996235.
      View in: PubMed
    4. Siddiqui S, Denlinger LC, Fowler SJ, Akuthota P, Shaw DE, Heaney LG, Brown L, Castro M, Winders TA, Kraft M, Wagers S, Peters MC, Pavord ID, Walker S, Jarjour NN. Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives. Am J Respir Crit Care Med. 2019 Apr 01; 199(7):823-829. PMID: 30726120.
      View in: PubMed
    5. Steinfeld J, Bradford ES, Brown J, Mallett S, Yancey SW, Akuthota P, Cid MC, Gleich GJ, Jayne D, Khoury P, Langford CA, Merkel PA, Moosig F, Specks U, Weller PF, Wechsler ME. Evaluation of clinical benefit from treatment with mepolizumab for patients with eosinophilic granulomatosis with polyangiitis. J Allergy Clin Immunol. 2019 Jun; 143(6):2170-2177. PMID: 30578883.
      View in: PubMed
    6. Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD. Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD). J Leukoc Biol. 2018 07; 104(1):69-83. PMID: 29672914.
      View in: PubMed
    7. Marshall DC, Salciccioli JD, Shea BS, Akuthota P. Trends in mortality from idiopathic pulmonary fibrosis in the European Union: an observational study of the WHO mortality database from 2001-2013. Eur Respir J. 2018 01; 51(1). PMID: 29348182.
      View in: PubMed
    8. Wechsler ME, Akuthota P, Khoury P. Novel Treatments for Airway Disease. N Engl J Med. 2017 08 10; 377(6):597-8. PMID: 28812971.
      View in: PubMed
    9. Wechsler ME, Akuthota P, Khoury P. Novel Treatments for Airway Disease. N Engl J Med. 2017 08 10; 377(6):597-8. PMID: 28792869.
      View in: PubMed
    10. Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ. Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. N Engl J Med. 2017 05 18; 376(20):1921-1932. PMID: 28514601.
      View in: PubMed
    11. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander LE. Hypoxia-inducible factor-1a inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 03; 176:94-99. PMID: 28093362.
      View in: PubMed
    12. Wang HB, Akuthota P, Kanaoka Y, Weller PF. Airway eosinophil migration into lymph nodes in mice depends on leukotriene C4. Allergy. 2017 Jun; 72(6):927-936. PMID: 27874209.
      View in: PubMed
    13. Akuthota P, Carmo LA, Bonjour K, Murphy RO, Silva TP, Gamalier JP, Capron KL, Tigges J, Toxavidis V, Camacho V, Ghiran I, Ueki S, Weller PF, Melo RC. Extracellular Microvesicle Production by Human Eosinophils Activated by "Inflammatory" Stimuli. Front Cell Dev Biol. 2016; 4:117. PMID: 27833910.
      View in: PubMed
    14. Michaud GC, Channick CL, Law AC, McCannon JB, Antkowiak M, Garrison G, Sayah D, Huynh RH, Brady AK, Adamson R, DuBrock H, Akuthota P, Marion C, Dela Cruz C, Town JA, Çoruh B, Thomson CC. ATS Core Curriculum 2016. Part IV. Adult Pulmonary Medicine Core Curriculum. Ann Am Thorac Soc. 2016 07; 13(7):1160-9. PMID: 27388404.
      View in: PubMed
    15. Crouch DR, Akuthota P. Asthma at the 2016 American Thoracic Society International Conference. J Thorac Dis. 2016 Jul; 8(Suppl 7):S556-8. PMID: 27606093.
      View in: PubMed
    16. Danielson KM, Estanislau J, Tigges J, Toxavidis V, Camacho V, Felton EJ, Khoory J, Kreimer S, Ivanov AR, Mantel PY, Jones J, Akuthota P, Das S, Ghiran I. Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry. PLoS One. 2016; 11(1):e0144678. PMID: 26745887.
      View in: PubMed
    17. Akuthota P, Weller PF. Spectrum of Eosinophilic End-Organ Manifestations. Immunol Allergy Clin North Am. 2015 Aug; 35(3):403-11. PMID: 26209892.
      View in: PubMed
    18. Akuthota P, Capron K, Weller PF. Eosinophil purification from peripheral blood. Methods Mol Biol. 2014; 1178:13-20. PMID: 24986603.
      View in: PubMed
    19. Akuthota P. Eosinophil interactions: antigen presentation. Methods Mol Biol. 2014; 1178:251-5. PMID: 24986622.
      View in: PubMed
    20. Akuthota P, Ueki S, Estanislau J, Weller PF. Human eosinophils express functional CCR7. Am J Respir Cell Mol Biol. 2013 Jun; 48(6):758-64. PMID: 23449735.
      View in: PubMed
    21. Akuthota P, Weller PF. Eosinophilic pneumonias. Clin Microbiol Rev. 2012 Oct; 25(4):649-60. PMID: 23034324.
      View in: PubMed
    22. Akuthota P, Shamri R, Weller PF. Isolation of human eosinophils. Curr Protoc Immunol. 2012 Aug; Chapter 7:Unit 7.31. PMID: 22855360.
      View in: PubMed
    23. Akuthota P, Litmanovich D, Zutler M, Boiselle PM, Bankier AA, Roberts DH, Celli BR, DeCamp MM, Berger RL. An evidence-based estimate on the size of the potential patient pool for lung volume reduction surgery. Ann Thorac Surg. 2012 Jul; 94(1):205-11. PMID: 22571881.
      View in: PubMed
    24. Akuthota P, Weller PF. Eosinophils and disease pathogenesis. Semin Hematol. 2012 Apr; 49(2):113-9. PMID: 22449621.
      View in: PubMed
    25. Cocchi MN, Giberson B, Berg K, Salciccioli JD, Naini A, Buettner C, Akuthota P, Gautam S, Donnino MW. Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation. 2012 Aug; 83(8):991-5. PMID: 22465806.
      View in: PubMed
    26. Theisen-Toupal J, Rosenthal ES, Kelly E, Zwicker JI, Akuthota P, Roberts DH. Pulmonary zygomycosis in a non-neutropenic patient with myelodysplastic syndrome on lenalidomide. Respir Care. 2012 Jul; 57(7):1175-7. PMID: 22369887.
      View in: PubMed
    27. Akuthota P, Melo RC, Spencer LA, Weller PF. MHC Class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):188-95. PMID: 21885678.
      View in: PubMed
    28. Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini AB, Buettner C, Akuthota P. Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. Crit Care. 2011 Aug 09; 15(4):R189. PMID: 21827677.
      View in: PubMed
    29. Akuthota P, Xenakis JJ, Weller PF. Eosinophils: offenders or general bystanders in allergic airway disease and pulmonary immunity? J Innate Immun. 2011; 3(2):113-9. PMID: 21228563.
      View in: PubMed
    30. Akuthota P, Wang H, Weller PF. Eosinophils as antigen-presenting cells in allergic upper airway disease. Curr Opin Allergy Clin Immunol. 2010 Feb; 10(1):14-9. PMID: 19949323.
      View in: PubMed
    31. Akuthota P, Wang HB, Spencer LA, Weller PF. Immunoregulatory roles of eosinophils: a new look at a familiar cell. Clin Exp Allergy. 2008 Aug; 38(8):1254-63. PMID: 18727793.
      View in: PubMed
    32. Rebeck GW, Cheung BS, Growdon WB, Deng A, Akuthota P, Locascio J, Greenberg SM, Hyman BT. Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease. Neurosci Lett. 1999 Sep 17; 272(3):155-8. PMID: 10505604.
      View in: PubMed