Praveen Akuthota

Title(s)Associate Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-6655-7520 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    UCSD2020Internal Medicine Graduating Housestaff Teaching Award
    UCSD2018Internal Medicine Chief Residents' Teaching Award
    UCSD2017Internal Medicine Graduating Housestaff Teaching Award
    2020San Diego Magazine "Top Docs"

    Collapse Overview 
    Collapse Overview
    Dr. Akuthota’s research efforts range from basic scientific investigations of human eosinophil biology and eosinophilic inflammation to clinical and translational efforts in asthma and eosinophilic pulmonary disease. He is the corresponding Principal Investigator for the UCSD Clinical Center in the National Heart, Lung, and Blood Institute’s PrecISE Network that will be studying precision interventions in severe asthma. He is a co-investigator on a study published in the New England Journal of Medicine showing the efficacy of anti-IL-5 therapy in the treatment of the eosinophilic disease EGPA (Churg Strauss syndrome). His research group is involved in other multicenter studies in eosinophilic disease and asthma. Basic science investigations from Dr. Akuthota focus on ex vivo studies of human eosinophils and include published work studying eosinophil trafficking and work studying microparticle release by eosinophils. He has written several reviews and chapters discussing eosinophil immunobiology and clinical considerations in eosinophilic diseases. Dr. Akuthota is an At-Large Member of the Board of Directors of the International Eosinophil Society (http://www.eosinophil-society.org/).

    Collapse Research 
    Collapse Research Activities and Funding
    San Diego Team Asthma Management using Phenotypes (STAMP)
    NIH UG1HL139117Sep 23, 2017 - Jun 30, 2023
    Role: Principal Investigator
    CC Chemokine-Mediated Differential Immunoregulation by Human Eosinophils
    NIH K08HL116429Aug 1, 2014 - Jul 31, 2020
    Role: Principal Investigator
    Tetraspanins in Asthma and Eosinophilic Lung Disease
    NIH F32AI081513Jul 17, 2009 - Jul 16, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Introducing the Severe Asthma Series of Invited Reviews. Chest. 2021 Oct; 160(4):1151-1152. Akuthota P, Jackson DJ, Wechsler ME. PMID: 34625156.
      View in: PubMed   Mentions:    Fields:    
    2. Diagnoses associated with peripheral blood eosinophilia: A 5-year review. Ann Allergy Asthma Immunol. 2021 Aug 13. Leverone N, Tran S, Barry J, Akuthota P. PMID: 34391899.
      View in: PubMed   Mentions:    Fields:    
    3. Atypical eosinophilic granulomatosis with polyangiitis with spontaneous aspirin reactivity and immunoglobulin E-mediated anaphylaxis. Ann Allergy Asthma Immunol. 2021 Oct; 127(4):506-507. Ball LL, Velasquez SA, Al Jammal OM, White AA, Akuthota P. PMID: 34273484.
      View in: PubMed   Mentions:    Fields:    
    4. Eosinophil-mediated inflammation in the absence of eosinophilia. Asia Pac Allergy. 2021 Jul; 11(3):e30. Miyabe Y, Kobayashi Y, Fukuchi M, Saga A, Moritoki Y, Saga T, Akuthota P, Ueki S. PMID: 34386406.
      View in: PubMed   Mentions:
    5. Defining a Severe Asthma Super-Responder: Findings from a Delphi Process. J Allergy Clin Immunol Pract. 2021 Jul 13. Upham JW, Le Lievre C, Jackson DJ, Masoli M, Wechsler ME, Price DB, Delphi Panel . PMID: 34271216.
      View in: PubMed   Mentions:    Fields:    
    6. PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment. J Allergy Clin Immunol. 2021 05; 147(5):1594-1601. Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A. PMID: 33667479.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Type 2 Biomarkers in Asthma: Yet Another Reflection of Heterogeneity. J Allergy Clin Immunol Pract. 2021 03; 9(3):1276-1277. Lugogo NL, Akuthota P. PMID: 33685610.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies. Annu Rev Immunol. 2021 04 26; 39:719-757. Jacobsen EA, Jackson DJ, Heffler E, Mathur SK, Bredenoord AJ, Pavord ID, Akuthota P, Roufosse F, Rothenberg ME. PMID: 33646859.
      View in: PubMed   Mentions: 6     Fields:    
    9. Critical Care Education in a Pandemic through Tele-ICU. ATS Sch. 2020 Dec 03; 2(1):29-33. Leverone NA, Ramnath VR, Munce D, Raphelson JR, Ma J, Akuthota P, Tomaszewski C, Sell RE, Crotty Alexander LE, Akrami KM, Malhotra A. PMID: 33870321.
      View in: PubMed   Mentions:
    10. Hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis and other eosinophilic lung diseases. Curr Opin Immunol. 2020 10; 66:129-135. Barry J, Gadre A, Akuthota P. PMID: 33166785.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. How Sex and Age of Asthma Onset Influence Difficult Asthma Heterogeneity. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3407-3408. Akuthota P, Busse WW. PMID: 33161965.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations. J Biopharm Stat. 2020 11 01; 30(6):1026-1037. Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR. PMID: 32941098.
      View in: PubMed   Mentions: 5     Fields:    
    13. Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype. Gastroenterology. 2020 11; 159(5):1778-1792.e13. Manresa MC, Chiang AWT, Kurten RC, Dohil R, Brickner H, Dohil L, Herro R, Akuthota P, Lewis NE, Croft M, Aceves SS. PMID: 32712105.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Two pediatric cases of ANCA-negative eosinophilic granulomatosis with polyangiitis successfully treated with dupilumab. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3643-3646.e1. Galant-Swafford J, Geng B, Leibel S, Akuthota P, Tucker S, Cernelc-Kohan M, Sheets R, Nation J, Jefferson AA. PMID: 32668296.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features. Am J Pathol. 2020 07; 190(7):1438-1448. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Dong ZM, Lin E, Wechsler ME, Weller PF, Klion AD, Bochner BS, Delker DA, Hazel MW, Fairfax K, Khoury P, Akuthota P, Merkel PA, Dyer AM, Langford C, Specks U, Gleich GJ, Chinchilli VM, Raby B, Yandell M, Clayton F. PMID: 32251643; PMCID: PMC7322366.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. Estimated Ventricular Size: A New Predictor of Asthma Severity and Exacerbation Rate? Chest. 2020 02; 157(2):243-244. Barry JR, Akuthota P. PMID: 32033641.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Eosinophilic Asthma. J Allergy Clin Immunol Pract. 2020 02; 8(2):465-473. Nelson RK, Bush A, Stokes J, Nair P, Akuthota P. PMID: 31786254.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    18. Editorial: Severe Eosinophilic Disorders: Mechanisms and Clinical Management. Front Immunol. 2019; 10:2118. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Akuthota P, Neves JS, Ueki S. PMID: 31552048; PMCID: PMC6737462.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF. J Immunol. 2019 07 15; 203(2):329-337. Nelson RK, Brickner H, Panwar B, Ramírez-Suástegui C, Herrera-de la Mata S, Liu N, Diaz D, Alexander LEC, Ay F, Vijayanand P, Seumois G, Akuthota P. PMID: 31175163.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. Sci Rep. 2019 04 17; 9(1):6206. Kurten RC, Rawson R, Shoda T, Duong LD, Adejumobi D, Levy R, Newbury RO, Rothenberg ME, Akuthota P, Wright BL, Dohil R, Jones SM, Aceves SS. PMID: 30996235.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives. Am J Respir Crit Care Med. 2019 04 01; 199(7):823-829. Siddiqui S, Denlinger LC, Fowler SJ, Akuthota P, Shaw DE, Heaney LG, Brown L, Castro M, Winders TA, Kraft M, Wagers S, Peters MC, Pavord ID, Walker S, Jarjour NN. PMID: 30726120.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. Evaluation of clinical benefit from treatment with mepolizumab for patients with eosinophilic granulomatosis with polyangiitis. J Allergy Clin Immunol. 2019 06; 143(6):2170-2177. Steinfeld J, Bradford ES, Brown J, Mallett S, Yancey SW, Akuthota P, Cid MC, Gleich GJ, Jayne D, Khoury P, Langford CA, Merkel PA, Moosig F, Specks U, Weller PF, Wechsler ME. PMID: 30578883.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
    23. Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD). J Leukoc Biol. 2018 07; 104(1):69-83. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD. PMID: 29672914; PMCID: PMC6171343.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. Trends in mortality from idiopathic pulmonary fibrosis in the European Union: an observational study of the WHO mortality database from 2001-2013. Eur Respir J. 2018 01; 51(1). Marshall DC, Salciccioli JD, Shea BS, Akuthota P. PMID: 29348182.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    25. Novel Treatments for Airway Disease. N Engl J Med. 2017 08 10; 377(6):597-8. Wechsler ME, Akuthota P, Khoury P. PMID: 28792869.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. N Engl J Med. 2017 05 18; 376(20):1921-1932. Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ, EGPA Mepolizumab Study Team . PMID: 28514601.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCellsCTClinical Trials
    27. Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 03; 176:94-99. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander LE. PMID: 28093362.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Airway eosinophil migration into lymph nodes in mice depends on leukotriene C4. Allergy. 2017 Jun; 72(6):927-936. Wang HB, Akuthota P, Kanaoka Y, Weller PF. PMID: 27874209.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    29. Extracellular Microvesicle Production by Human Eosinophils Activated by "Inflammatory" Stimuli. Front Cell Dev Biol. 2016; 4:117. Akuthota P, Carmo LA, Bonjour K, Murphy RO, Silva TP, Gamalier JP, Capron KL, Tigges J, Toxavidis V, Camacho V, Ghiran I, Ueki S, Weller PF, Melo RC. PMID: 27833910.
      View in: PubMed   Mentions:
    30. ATS Core Curriculum 2016. Part IV. Adult Pulmonary Medicine Core Curriculum. Ann Am Thorac Soc. 2016 07; 13(7):1160-9. Michaud GC, Channick CL, Law AC, McCannon JB, Antkowiak M, Garrison G, Sayah D, Huynh RH, Brady AK, Adamson R, DuBrock H, Akuthota P, Marion C, Dela Cruz C, Town JA, Çoruh B, Thomson CC. PMID: 27388404.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Asthma at the 2016 American Thoracic Society International Conference. J Thorac Dis. 2016 Jul; 8(Suppl 7):S556-8. Crouch DR, Akuthota P. PMID: 27606093.
      View in: PubMed   Mentions:
    32. Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry. PLoS One. 2016; 11(1):e0144678. Danielson KM, Estanislau J, Tigges J, Toxavidis V, Camacho V, Felton EJ, Khoory J, Kreimer S, Ivanov AR, Mantel PY, Jones J, Akuthota P, Das S, Ghiran I. PMID: 26745887.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    33. Spectrum of Eosinophilic End-Organ Manifestations. Immunol Allergy Clin North Am. 2015 Aug; 35(3):403-11. Akuthota P, Weller PF. PMID: 26209892.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. Eosinophil purification from peripheral blood. Methods Mol Biol. 2014; 1178:13-20. Akuthota P, Capron K, Weller PF. PMID: 24986603.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Eosinophil interactions: antigen presentation. Methods Mol Biol. 2014; 1178:251-5. Akuthota P. PMID: 24986622.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    36. Human eosinophils express functional CCR7. Am J Respir Cell Mol Biol. 2013 Jun; 48(6):758-64. Akuthota P, Ueki S, Estanislau J, Weller PF. PMID: 23449735.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. Eosinophilic pneumonias. Clin Microbiol Rev. 2012 Oct; 25(4):649-60. Akuthota P, Weller PF. PMID: 23034324.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    38. Isolation of human eosinophils. Curr Protoc Immunol. 2012 Aug; Chapter 7:Unit 7.31. Akuthota P, Shamri R, Weller PF. PMID: 22855360.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. An evidence-based estimate on the size of the potential patient pool for lung volume reduction surgery. Ann Thorac Surg. 2012 Jul; 94(1):205-11. Akuthota P, Litmanovich D, Zutler M, Boiselle PM, Bankier AA, Roberts DH, Celli BR, DeCamp MM, Berger RL. PMID: 22571881.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. Eosinophils and disease pathogenesis. Semin Hematol. 2012 Apr; 49(2):113-9. Akuthota P, Weller PF. PMID: 22449621.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation. 2012 Aug; 83(8):991-5. Cocchi MN, Giberson B, Berg K, Salciccioli JD, Naini A, Buettner C, Akuthota P, Gautam S, Donnino MW. PMID: 22465806.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    42. Pulmonary zygomycosis in a non-neutropenic patient with myelodysplastic syndrome on lenalidomide. Respir Care. 2012 Jul; 57(7):1175-7. Theisen-Toupal J, Rosenthal ES, Kelly E, Zwicker JI, Akuthota P, Roberts DH. PMID: 22369887.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. MHC Class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):188-95. Akuthota P, Melo RC, Spencer LA, Weller PF. PMID: 21885678.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    44. Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. Crit Care. 2011 Aug 09; 15(4):R189. Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini AB, Buettner C, Akuthota P. PMID: 21827677.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    45. Eosinophils: offenders or general bystanders in allergic airway disease and pulmonary immunity? J Innate Immun. 2011; 3(2):113-9. Akuthota P, Xenakis JJ, Weller PF. PMID: 21228563.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    46. Eosinophils as antigen-presenting cells in allergic upper airway disease. Curr Opin Allergy Clin Immunol. 2010 Feb; 10(1):14-9. Akuthota P, Wang H, Weller PF. PMID: 19949323.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    47. Immunoregulatory roles of eosinophils: a new look at a familiar cell. Clin Exp Allergy. 2008 Aug; 38(8):1254-63. Akuthota P, Wang HB, Spencer LA, Weller PF. PMID: 18727793.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    48. Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease. Neurosci Lett. 1999 Sep 17; 272(3):155-8. Rebeck GW, Cheung BS, Growdon WB, Deng A, Akuthota P, Locascio J, Greenberg SM, Hyman BT. PMID: 10505604.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
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