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Seth Kligerman

Title(s)Associate Professor Of Clinical, Radiology
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    Massachusetts General Hospital, Boston, MA06/2009Cardiothoracic Radiology
    University of Colorado, Denver, CO06/2008Radiology
    Chicago Medical School, North Chicago, ILMD06/2003Medicine
    Finch University of Health Sciences, North Chicago, ILMS06/1999Physiology
    Amherst College, Amherst, MABA06/1997History
    Collapse Awards and Honors
    RSNA2007Resident Research Award
    ACR2006JT Rutherford Fellowship
    RSNA2005Introduction to Research Scholarship
    ARRS2009Silver Medal Recipient
    Journal of Thoracic Imaging 2014Editors' Recognition Award
    Journal of Thoracic Imaging 2015Editors' Recognition Award

    Collapse Overview 
    Collapse Overview
    Dr. Kligerman is an Associate Professor of Radiology and Section Chief of Cardiothoracic Imaging at the University of California, San Diego. He obtained his BA from Amherst College, MD from Chicago Medical School, and did residency training at the University of Colorado. After fellowship at Massachusetts General Hospital, Dr. Kligerman joined the section of cardiothoracic imaging at the University of Maryland. In less than 9 years since completing his training, he has published over 55 peer-reviewed articles, presented over 30 abstracts, and serves on the research committees of RSNA, STR, and NASCI. Much of his research has been focused on low-dose CT imaging and advanced reconstruction techniques. Dr. Kligerman is a lecturer in both cardiac and thoracic imaging at the American Institute of Radiologic pathology (AIRP) and has been invited to give over 200 lectures nationally and internationally.

    Collapse Research 
    Collapse Research Activities and Funding
    4D Robust Optimization in Intensity-Modulated Proton Therapy
    NIH K25CA168984Aug 13, 2012 - Jul 31, 2016
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Henry TS, Kanne JP, Kligerman SJ. Imaging of Vaping-Associated Lung Disease. N Engl J Med. 2019 Sep 06. PMID: 31491070.
      View in: PubMed
    2. Henry TS, Hammer MM, Little BP, Jensen LE, Kligerman SJ, Kanne JP, Mann H. Smoke: How to Differentiate Flow-related Artifacts From Pathology on Thoracic Computed Tomographic Angiography. J Thorac Imaging. 2019 Jun 14. PMID: 31206454.
      View in: PubMed
    3. Kligerman S. Imaging of Pericardial Disease. Radiol Clin North Am. 2019 Jan; 57(1):179-199. PMID: 30454812.
      View in: PubMed
    4. Jacobs K, Kligerman S. Immune-Mediated Lung Diseases. Semin Ultrasound CT MR. 2019 Jun; 40(3):213-228. PMID: 31200870.
      View in: PubMed
    5. Kligerman SJ, Mitchell JW, Sechrist JW, Meeks AK, Galvin JR, White CS. Radiologist Performance in the Detection of Pulmonary Embolism: Features that Favor Correct Interpretation and Risk Factors for Errors. J Thorac Imaging. 2018 Nov; 33(6):350-357. PMID: 30142136.
      View in: PubMed
    6. Choi W, Riyahi S, Kligerman SJ, Liu CJ, Mechalakos JG, Lu W. Technical Note: Identification of CT Texture Features Robust to Tumor Size Variations for Normal Lung Texture Analysis. Int J Med Phys Clin Eng Radiat Oncol. 2018 Aug; 7(3):330-338. PMID: 31131158.
      View in: PubMed
    7. Jeudy J, White CS, Kligerman SJ, Killam JL, Burke AP, Sechrist JW, Shah AB, Hossain R, Frazier AA. Spectrum of Coronary Artery Aneurysms: From the Radiologic Pathology Archives. Radiographics. 2018 Jan-Feb; 38(1):11-36. PMID: 29320324.
      View in: PubMed
    8. Kalchiem-Dekel O, Paulk A, Kligerman SJ, Burke AP, Shah NG, Dixon RK. Development of pulmonary Langerhans cell histiocytosis in a patient with established adenocarcinoma of the lung. J Thorac Dis. 2017 Dec; 9(12):E1079-E1083. PMID: 29312770.
      View in: PubMed
    9. Babiker A, Jeudy J, Kligerman S, Khambaty M, Shah A, Bagchi S. Risk of Cardiovascular Disease Due to Chronic Hepatitis C Infection: A Review. J Clin Transl Hepatol. 2017 Dec 28; 5(4):343-362. PMID: 29226101.
      View in: PubMed
    10. Malik N, Claus PL, Illman JE, Kligerman SJ, Moynagh MR, Levin DL, Woodrum DA, Arani A, Arunachalam SP, Araoz PA. Air embolism: diagnosis and management. Future Cardiol. 2017 07; 13(4):365-378. PMID: 28644058.
      View in: PubMed
    11. Holden VK, Kligerman SJ, Hastings TG, Hines SE. Unabated occupational risk in a patient with rheumatoid pulmonary fibrosis. Occup Med (Lond). 2017 Jun 01; 67(4):311-313. PMID: 28339739.
      View in: PubMed
    12. Kligerman S, Bolster F, Mitchell J, Henry T, Jeudy J, White CS. Use of Model-based Iterative Reconstruction to Improve Detection of Congenital Cardiovascular Anomalies in Infants Undergoing Free-breathing Computed Tomographic Angiography. J Thorac Imaging. 2017 Mar; 32(2):127-135. PMID: 28221263.
      View in: PubMed
    13. Kligerman SJ, Auerbach A, Franks TJ, Galvin JR. Castleman Disease of the Thorax: Clinical, Radiologic, and Pathologic Correlation: From the Radiologic Pathology Archives. Radiographics. 2016 Sep-Oct; 36(5):1309-32. PMID: 27618318.
      View in: PubMed
    14. Kligerman S, Franks TJ, Galvin JR. Clinical-Radiologic-Pathologic Correlation of Smoking-Related Diffuse Parenchymal Lung Disease. Radiol Clin North Am. 2016 Nov; 54(6):1047-1063. PMID: 27719975.
      View in: PubMed
    15. Kligerman SJ, Franks TJ, Galvin JR. Primary Extranodal Lymphoma of the Thorax. Radiol Clin North Am. 2016 Jul; 54(4):673-87. PMID: 27265602.
      View in: PubMed
    16. Mannina A, Chung JH, Swigris JJ, Solomon JJ, Huie TJ, Yunt ZX, Truong TQ, Brown KK, Achcar RD, Olson AL, Cox CW, Kligerman SJ, Curran-Everett D, Fernández Pérez ER. Clinical Predictors of a Diagnosis of Common Variable Immunodeficiency-related Granulomatous-Lymphocytic Interstitial Lung Disease. Ann Am Thorac Soc. 2016 07; 13(7):1042-9. PMID: 27064856.
      View in: PubMed
    17. Illman JE, Maleszewski JJ, Byrne SC, Gotway MB, Kligerman SJ, Foley TA, Young PM, Bois JP, Malik N, Morris JM, Araoz PA. Multimodality imaging of foreign bodies in and around the heart. Future Cardiol. 2016 05; 12(3):351-71. PMID: 27139781.
      View in: PubMed
    18. Hussien AF, Jeudy J, Kligerman SJ, White CS. Thoracic Incidental Findings in Preoperative Computed Tomography Evaluation for Transcatheter Aortic Valve Implantation (TAVI). J Thorac Imaging. 2016 May; 31(3):183-8. PMID: 27082418.
      View in: PubMed
    19. Terpenning S, Deng M, Hong-Zohlman SN, Lin CT, Kligerman SJ, Jeudy J, Ketai LH. CT measurement of central pulmonary arteries to diagnose pulmonary hypertension (PHTN): more reliable than valid? Clin Imaging. 2016 Jul-Aug; 40(4):821-7. PMID: 27131412.
      View in: PubMed
    20. Jonas SN, Kligerman SJ, Burke AP, Frazier AA, White CS. Pulmonary Valve Anatomy and Abnormalities: A Pictorial Essay of Radiography, Computed Tomography (CT), and Magnetic Resonance Imaging (MRI). J Thorac Imaging. 2016 Jan; 31(1):W4-12. PMID: 26656195.
      View in: PubMed
    21. Todd NW, Marciniak ET, Sachdeva A, Kligerman SJ, Galvin JR, Luzina IG, Atamas SP, Burke AP. Organizing pneumonia/non-specific interstitial pneumonia overlap is associated with unfavorable lung disease progression. Respir Med. 2015 Nov; 109(11):1460-8. PMID: 26482523.
      View in: PubMed
    22. Trimble CR, Burke A, Kligerman S. Primary Cardiac Osteosarcoma: AIRP Best Cases in Radiologic-Pathologic Correlation. Radiographics. 2015 Sep-Oct; 35(5):1352-7. PMID: 26371582.
      View in: PubMed
    23. Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR. Mosaic Attenuation: Etiology, Methods of Differentiation, and Pitfalls. Radiographics. 2015 Sep-Oct; 35(5):1360-80. PMID: 26274445.
      View in: PubMed
    24. Li C, Lin CT, Kligerman SJ, Hong SN, White CS. Enhancement Characteristics of the Computed Tomography Pulmonary Angiography Test Bolus Curve and Its Use in Predicting Right Ventricular Dysfunction and Mortality in Patients With Acute Pulmonary Embolism. J Thorac Imaging. 2015 Jul; 30(4):274-81. PMID: 25635705.
      View in: PubMed
    25. Lu W, Tan S, Chen W, Kligerman S, Feigenberg SJ, Zhang H, Suntharalingam M, Kang M, D'Souza WD. Pre-Chemoradiotherapy FDG PET/CT cannot Identify Residual Metabolically-Active Volumes within Individual Esophageal Tumors. J Nucl Med Radiat Ther. 2015 May; 6(3). PMID: 26594591.
      View in: PubMed
    26. Shin T, Kligerman SJ, Crawford RS, Rajagopalan S, Gullapalli RP. Noncontrast-enhanced peripheral venography using velocity-selective magnetization preparation and transient balanced SSFP. Magn Reson Med. 2016 Feb; 75(2):653-64. PMID: 25824323.
      View in: PubMed
    27. Sonoda A, Jeudy J, White CS, Kligerman SJ, Nitta N, Lempel J, Frazier AA. Pleurodesis: indications and radiologic appearance. Jpn J Radiol. 2015 May; 33(5):241-5. PMID: 25791777.
      View in: PubMed
    28. Lin J, Kligerman S, Goel R, Sajedi P, Suntharalingam M, Chuong MD. State-of-the-art molecular imaging in esophageal cancer management: implications for diagnosis, prognosis, and treatment. J Gastrointest Oncol. 2015 Feb; 6(1):3-19. PMID: 25642333.
      View in: PubMed
    29. Kligerman S, Lahiji K, Weihe E, Lin CT, Terpenning S, Jeudy J, Frazier A, Pugatch R, Galvin JR, Mittal D, Kothari K, White CS. Detection of pulmonary embolism on computed tomography: improvement using a model-based iterative reconstruction algorithm compared with filtered back projection and iterative reconstruction algorithms. J Thorac Imaging. 2015 Jan; 30(1):60-8. PMID: 25423129.
      View in: PubMed
    30. White CS, Lim KY, Kligerman S, Lin CT. Reply to "Unexpected lung parenchymal findings on nonenhanced abdominal CT may raise suspicion of PE". AJR Am J Roentgenol. 2014 Dec; 203(6):W746. PMID: 25415744.
      View in: PubMed
    31. Staats P, Kligerman S, Todd N, Tavora F, Xu L, Burke A. A comparative study of honeycombing on high resolution computed tomography with histologic lung remodeling in explants with usual interstitial pneumonia. Pathol Res Pract. 2015 Jan; 211(1):55-61. PMID: 25433993.
      View in: PubMed
    32. Lahiji K, Kligerman S, Jeudy J, White C. Improved accuracy of pulmonary embolism computer-aided detection using iterative reconstruction compared with filtered back projection. AJR Am J Roentgenol. 2014 Oct; 203(4):763-71. PMID: 25247942.
      View in: PubMed
    33. Reed RM, Amoroso A, Hashmi S, Kligerman S, Shuldiner AR, Mitchell BD, Netzer G. Calcified granulomatous disease: occupational associations and lack of familial aggregation. Lung. 2014 Dec; 192(6):841-7. PMID: 25038755.
      View in: PubMed
    34. Ramani GV, Kligerman SJ, Reed RM. A bad shortcut: partial anomalous pulmonary venous return. BMJ Case Rep. 2014 Apr 11; 2014. PMID: 24728898.
      View in: PubMed
    35. Lim KY, Kligerman SJ, Lin CT, White CS. Missed pulmonary embolism on abdominal CT. AJR Am J Roentgenol. 2014 Apr; 202(4):738-43. PMID: 24660700.
      View in: PubMed
    36. Lempel JK, Frazier AA, Jeudy J, Kligerman SJ, Schultz R, Ninalowo HA, Gozansky EK, Griffith B, White CS. Aortic arch dissection: a controversy of classification. Radiology. 2014 Jun; 271(3):848-55. PMID: 24617732.
      View in: PubMed
    37. Kligerman SJ, Lahiji K, Galvin JR, Stokum C, White CS. Missed pulmonary emboli on CT angiography: assessment with pulmonary embolism-computer-aided detection. AJR Am J Roentgenol. 2014 Jan; 202(1):65-73. PMID: 24370130.
      View in: PubMed
    38. Kligerman SJ, White CS. Image quality and feasibility of an ultralow-dose high-pitch helical triple-rule-out computed tomography angiography acquired in the caudocranial direction. J Thorac Imaging. 2014 Jan; 29(1):50-9. PMID: 24247084.
      View in: PubMed
    39. Xue M, Zhang H, Kligerman S, Klahr P, D'Souza W, Lu W. Individually optimized uniform contrast enhancement in CT angiography for the diagnosis of pulmonary thromboembolic disease--a simulation study. Med Phys. 2013 Dec; 40(12):121906. PMID: 24320517.
      View in: PubMed
    40. Zhang H, Tan S, Chen W, Kligerman S, Kim G, D'Souza WD, Suntharalingam M, Lu W. Modeling pathologic response of esophageal cancer to chemoradiation therapy using spatial-temporal 18F-FDG PET features, clinical parameters, and demographics. Int J Radiat Oncol Biol Phys. 2014 Jan 01; 88(1):195-203. PMID: 24189128.
      View in: PubMed
    41. Kligerman SJ, Franks TJ, Galvin JR. From the radiologic pathology archives: organization and fibrosis as a response to lung injury in diffuse alveolar damage, organizing pneumonia, and acute fibrinous and organizing pneumonia. Radiographics. 2013 Nov-Dec; 33(7):1951-75. PMID: 24224590.
      View in: PubMed
    42. Kligerman S. The clinical staging of lung cancer through imaging: a radiologist's guide to the revised staging system and rationale for the changes. Radiol Clin North Am. 2014 Jan; 52(1):69-83. PMID: 24267711.
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    43. Hines SE, Gucer P, Kligerman S, Breyer R, Centeno J, Gaitens J, Oliver M, Engelhardt S, Squibb K, McDiarmid M. Pulmonary health effects in Gulf War I service members exposed to depleted uranium. J Occup Environ Med. 2013 Aug; 55(8):937-44. PMID: 23887699.
      View in: PubMed
    44. Kligerman S, Cai L, White CS. The effect of computer-aided detection on radiologist performance in the detection of lung cancers previously missed on a chest radiograph. J Thorac Imaging. 2013 Jul; 28(4):244-52. PMID: 23059738.
      View in: PubMed
    45. Lempel JK, Jeudy J, Kligerman SJ, White CS. The nubbin sign. J Thorac Imaging. 2013 May; 28(3):W42. PMID: 23571449.
      View in: PubMed
    46. Xu L, Kligerman S, Burke A. End-stage sarcoid lung disease is distinct from usual interstitial pneumonia. Am J Surg Pathol. 2013 Apr; 37(4):593-600. PMID: 23426125.
      View in: PubMed
    47. Kligerman S, Mehta D, Farnadesh M, Jeudy J, Olsen K, White C. Use of a hybrid iterative reconstruction technique to reduce image noise and improve image quality in obese patients undergoing computed tomographic pulmonary angiography. J Thorac Imaging. 2013 Jan; 28(1):49-59. PMID: 22576762.
      View in: PubMed
    48. Tan S, Kligerman S, Chen W, Lu M, Kim G, Feigenberg S, D'Souza WD, Suntharalingam M, Lu W. Spatial-temporal [¹8F]FDG-PET features for predicting pathologic response of esophageal cancer to neoadjuvant chemoradiation therapy. Int J Radiat Oncol Biol Phys. 2013 Apr 01; 85(5):1375-82. PMID: 23219566.
      View in: PubMed
    49. Tan S, Zhang H, Kligerman S, Chen W, Kim G, Feigenberg S, D'Souza W, Suntharalingam M, Lu W. SU-D-BRB-04: FDG-PET Histogram Distances: Novel Predictors of Tumor Response to Chemoradiotherapy. Med Phys. 2012 Jun; 39(6Part3):3615. PMID: 28517413.
      View in: PubMed
    50. Ramani GV, Kligerman S, Lehr E. Multimodality imaging of thrombus in transit crossing a patent foramen ovale. J Am Coll Cardiol. 2012 Mar 06; 59(10):e19. PMID: 22381436.
      View in: PubMed
    51. Kligerman S, White C. Imaging characteristics of lung cancer. Semin Roentgenol. 2011 Jul; 46(3):194-207. PMID: 21726704.
      View in: PubMed
    52. Kligerman S, White C. Assessment of acute chest pain in the emergency department: Evaluation of the Rule Out Myocardial Infarction Using Computer Assisted Tomography (ROMICAT) trial and its future implications. Curr Cardiol Rep. 2011 Feb; 13(1):6-8. PMID: 20890687.
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    53. Kligerman S, White C. Epidemiology of lung cancer in women: risk factors, survival, and screening. AJR Am J Roentgenol. 2011 Feb; 196(2):287-95. PMID: 21257878.
      View in: PubMed
    54. Kligerman S, Abbott G. A radiologic review of the new TNM classification for lung cancer. AJR Am J Roentgenol. 2010 Mar; 194(3):562-73. PMID: 20173129.
      View in: PubMed
    55. Isselbacher EM, Kligerman SJ, Lam KM, Hurtado RM. Case records of the Massachusetts General Hospital. Case 2-2010. A 47-year-old man with abdominal and flank pain. N Engl J Med. 2010 Jan 21; 362(3):254-62. PMID: 20089976.
      View in: PubMed
    56. Kligerman S, Digumarthy S. Staging of non-small cell lung cancer using integrated PET/CT. AJR Am J Roentgenol. 2009 Nov; 193(5):1203-11. PMID: 19843732.
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    57. Kligerman S, Blum A, Abbara S. Persistent fifth aortic arch in a patient with a history of intrauterine thalidomide exposure. J Cardiovasc Comput Tomogr. 2009 Nov-Dec; 3(6):412-4. PMID: 19709946.
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    58. Kligerman SJ, Groshong S, Brown KK, Lynch DA. Nonspecific interstitial pneumonia: radiologic, clinical, and pathologic considerations. Radiographics. 2009 Jan-Feb; 29(1):73-87. PMID: 19168837.
      View in: PubMed
    59. Kligerman S, Sharma A. Radiologic evaluation of the trachea. Semin Thorac Cardiovasc Surg. 2009; 21(3):246-54. PMID: 19942124.
      View in: PubMed
    60. Jonisch AI, Kligerman S, Nagy E, Bhargavan M, Forman HP, Sunshine J. What characterizes academic radiology departments that secure large amounts of external funding for research? Acad Radiol. 2006 Dec; 13(12):1513-6. PMID: 17191360.
      View in: PubMed
    61. Reddy KR, Kligerman S, Levi J, Livingstone A, Molina E, Franceschi D, Badalamenti S, Jeffers L, Tzakis A, Schiff ER. Benign and solid tumors of the liver: relationship to sex, age, size of tumors, and outcome. Am Surg. 2001 Feb; 67(2):173-8. PMID: 11243545.
      View in: PubMed
    62. Reddy KR, Levi J, Livingstone A, Jeffers L, Molina E, Kligerman S, Bernstein D, Kodali VP, Schiff ER. Experience with staging laparoscopy in pancreatic malignancy. Gastrointest Endosc. 1999 Apr; 49(4 Pt 1):498-503. PMID: 10202066.
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    63. KLIGERMAN S. A program of teaching a psychodynamic orientation to resident physicians in medicine. Psychosom Med. 1952 Jul-Aug; 14(4):277-83. PMID: 14949298.
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    64. KLIGERMAN S. A program of teaching a psychodynamic orientation to resident physicians in medicine. J Nerv Ment Dis. 1952 Apr; 115(4):362-4. PMID: 14918019.
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    65. KLIGERMAN S. Program of teaching a psychodynamic orientation to resident physicians in medicine. AMA Arch Neurol Psychiatry. 1951 Nov; 66(5):652-3. PMID: 14868032.
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    66. MURPHY WF, KLIGERMAN S. The associative anamnesis in teaching insight psychotherapy. Dis Nerv Syst. 1950 Oct; 11(10):291-7. PMID: 14793396.
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