David Mcculley

Title(s)	Associate Professor, Pediatrics
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
vCard	Download vCard

Research

Research Activities and Funding

GENETIC AND DEVELOPMENTAL MECHANISMS OF CONGENITAL DIAPHRAGMATIC HERNIA
NIH R01HL146859Apr 4, 2019 - Mar 31, 2024
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

MYRF is Essential in Mesothelial Cells to Promote Lung Development and Maturation. bioRxiv. 2025 Feb 14. Luna G, Verheyden J, Tan C, Kim E, Hwa M, Sahi J, Shen Y, Chung W, McCulley D, Sun X. PMID: 39990361; PMCID: PMC11844445.

View in: PubMed Mentions:
Risk Factors Associated With the Development of Late Pulmonary Artery Hypertension in Extremely Premature Infants. Pediatr Pulmonol. 2025 Feb; 60(2):e27501. Condit PE, Hokanson JS, Balasubramaniam V, McCulley DJ, Lasarev M, Lamers L, McAdams RM, Kaluarachchi DC. PMID: 39945565; PMCID: PMC11823566.

View in: PubMed Mentions: Fields:
Ped Pediatrics Pul Pulmonary Medicine
A Single Early Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung. Am J Respir Cell Mol Biol. 2025 Jan 21. Grayck MR, Smith BJ, Sosa A, Golden E, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Dobrinskikh E, Rincon M, McCulley DJ, Orlicky DJ, Wright CJ. PMID: 39836061.

View in: PubMed Mentions: Fields:
Cel Cell Biology Mol Molecular Biology
Common variants increase risk for congenital diaphragmatic hernia within the context of de novo variants. Am J Hum Genet. 2024 Nov 07; 111(11):2362-2381. Qiao L, Welch CL, Hernan R, Wynn J, Krishnan US, Zalieckas JM, Buchmiller T, Khlevner J, De A, Farkouh-Karoleski C, Wagner AJ, Heydweiller A, Mueller AC, de Klein A, Warner BW, Maj C, Chung D, McCulley DJ, Schindel D, Potoka D, Fialkowski E, Schulz F, Kipfmuller F, Lim FY, Magielsen F, Mychaliska GB, Aspelund G, Reutter HM, Needelman H, Schnater JM, Fisher JC, Azarow K, Elfiky M, Nöthen MM, Danko ME, Li M, Kosinski P, Wijnen RMH, Cusick RA, Soffer SZ, Cochius-Den Otter SCM, Schaible T, Crombleholme T, Duron VP, Donahoe PK, Sun X, High FA, Bendixen C, Brosens E, Shen Y, Chung WK. PMID: 39332409; PMCID: PMC11568762.

View in: PubMed Mentions: Fields:
Gen Genetics
Translation:Humans
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 10 03; 31(10):1465-1483.e6. Xu L, Tan C, Barr J, Talaba N, Verheyden J, Chin JS, Gaboyan S, Kasaraneni N, Elgamal RM, Gaulton KJ, Lin G, Afshar K, Golts E, Meier A, Crotty Alexander LE, Borok Z, Shen Y, Chung WK, McCulley DJ, Sun X. PMID: 39181129.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology
Rescuing lung development through embryonic inhibition of histone acetylation. Sci Transl Med. 2024 Jan 31; 16(732):eadc8930. Stokes G, Li Z, Talaba N, Genthe W, Brix MB, Pham B, Wienhold MD, Sandok G, Hernan R, Wynn J, Tang H, Tabima DM, Rodgers A, Hacker TA, Chesler NC, Zhang P, Murad R, Yuan JX, Shen Y, Chung WK, McCulley DJ. PMID: 38295182.

View in: PubMed Mentions: 1 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
PLS3 missense variants affecting the actin-binding domains cause X-linked congenital diaphragmatic hernia and body-wall defects. Am J Hum Genet. 2023 10 05; 110(10):1787-1803. Petit F, Longoni M, Wells J, Maser RS, Bogenschutz EL, Dysart MJ, Contreras HTM, Frénois F, Pober BR, Clark RD, Giampietro PF, Ropers HH, Hu H, Loscertales M, Wagner R, Ai X, Brand H, Jourdain AS, Delrue MA, Gilbert-Dussardier B, Devisme L, Keren B, McCulley DJ, Qiao L, Hernan R, Wynn J, Scott TM, Calame DG, Coban-Akdemir Z, Hernandez P, Hernandez-Garcia A, Yonath H, Lupski JR, Shen Y, Chung WK, Scott DA, Bult CJ, Donahoe PK, High FA. PMID: 37751738; PMCID: PMC10577083.

View in: PubMed Mentions: 2 Fields:
Gen Genetics
Translation:Humans Animals
Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated? J Perinatol. 2023 10; 43(10):1230-1237. Wright CJ, McCulley DJ, Mitra S, Jensen EA. PMID: 37169914; PMCID: PMC10626600.

View in: PubMed Mentions: 1 Fields:
Per Perinatology
Translation:Humans
Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L1-L13. McCulley DJ, Jensen EA, Sucre JMS, McKenna S, Sherlock LG, Dobrinskikh E, Wright CJ. PMID: 35503238; PMCID: PMC9208439.

View in: PubMed Mentions: Fields:
Cel Cell Biology Mol Molecular Biology Phy Physiology Pul Pulmonary Medicine
Translation:Humans
Being small for gestational age is not an independent risk factor for mortality in neonates with congenital diaphragmatic hernia: a multicenter study. J Perinatol. 2022 09; 42(9):1183-1188. Zenilman A, Fan W, Hernan R, Wynn J, Abramov A, Farkouh-Karoleski C, Aspelund G, Krishnan US, Khlevner J, Azarow K, Crombleholme T, Cusick R, Chung D, Danko ME, Potoka D, Lim FY, McCulley DJ, Mychaliska GB, Schindel D, Soffer S, Wagner AJ, Warner BW, Chung WK, Duron VP. PMID: 35449444.

View in: PubMed Mentions: 1 Fields:
Per Perinatology
Translation:Humans
Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene. Am J Hum Genet. 2021 10 07; 108(10):1964-1980. Qiao L, Xu L, Yu L, Wynn J, Hernan R, Zhou X, Farkouh-Karoleski C, Krishnan US, Khlevner J, De A, Zygmunt A, Crombleholme T, Lim FY, Needelman H, Cusick RA, Mychaliska GB, Warner BW, Wagner AJ, Danko ME, Chung D, Potoka D, Kosinski P, McCulley DJ, Elfiky M, Azarow K, Fialkowski E, Schindel D, Soffer SZ, Lyon JB, Zalieckas JM, Vardarajan BN, Aspelund G, Duron VP, High FA, Sun X, Donahoe PK, Shen Y, Chung WK. PMID: 34547244; PMCID: PMC8546037.

View in: PubMed Mentions: 15 Fields:
Gen Genetics
Translation:Humans Animals
Neurally-Adjusted Ventilatory Assist Can Facilitate Extubation in Neonates With Congenital Diaphragmatic Hernia. Respir Care. 2021 Jan; 66(1):41-49. Meinen RD, Alali YI, Al-Subu A, Wilhelm M, Wraight CL, McAdams RM, Limjoco JJ, McCulley DJ. PMID: 32753531.

View in: PubMed Mentions: 4 Fields:
Pul Pulmonary Medicine
Translation:Humans
Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes. Genet Med. 2020 12; 22(12):2020-2028. Qiao L, Wynn J, Yu L, Hernan R, Zhou X, Duron V, Aspelund G, Farkouh-Karoleski C, Zygumunt A, Krishnan US, Nees S, Khlevner J, Lim FY, Crombleholme T, Cusick R, Azarow K, Danko ME, Chung D, Warner BW, Mychaliska GB, Potoka D, Wagner AJ, Soffer S, Schindel D, McCulley DJ, Shen Y, Chung WK. PMID: 32719394; PMCID: PMC7710626.

View in: PubMed Mentions: 15 Fields:
Gen Genetics
Translation:Humans
Comparative outcomes of right versus left congenital diaphragmatic hernia: A multicenter analysis. J Pediatr Surg. 2020 Jan; 55(1):33-38. Abramov A, Fan W, Hernan R, Zenilman AL, Wynn J, Aspelund G, Khlevner J, Krishnan U, Lim FY, Mychaliska GB, Warner BW, Cusick R, Crombleholme T, Chung D, Danko ME, Wagner AJ, Azarow K, Schindel D, Potoka D, Soffer S, Fisher J, McCulley D, Farkouh-Karoleski C, Chung WK, Duron V. PMID: 31677822.

View in: PubMed Mentions: 11 Fields:
Gen General Surgery Ped Pediatrics
Translation:Humans
PBX transcription factors drive pulmonary vascular adaptation to birth. J Clin Invest. 2018 02 01; 128(2):655-667. McCulley DJ, Wienhold MD, Hines EA, Hacker TA, Rogers A, Pewowaruk RJ, Zewdu R, Chesler NC, Selleri L, Sun X. PMID: 29251627; PMCID: PMC5785269.

View in: PubMed Mentions: 15 Fields:
Med Medicine (General)
Translation:Animals Cells
Congenital diaphragmatic hernias: from genes to mechanisms to therapies. Dis Model Mech. 2017 08 01; 10(8):955-970. Kardon G, Ackerman KG, McCulley DJ, Shen Y, Wynn J, Shang L, Bogenschutz E, Sun X, Chung WK. PMID: 28768736; PMCID: PMC5560060.

View in: PubMed Mentions: 68 Fields:
Med Medicine (General)
Translation:Humans Animals
Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis. Dev Dyn. 2016 Apr; 245(4):497-507. Hines EA, Verheyden JM, Lashua AJ, Larson SC, Branchfield K, Domyan ET, Gao J, Harvey JF, Herriges JC, Hu L, Mcculley DJ, Throckmorton K, Yokoyama S, Ikeda A, Xu G, Sun X. PMID: 26813283; PMCID: PMC4860343.

View in: PubMed Mentions: 4 Fields:
Ana Anatomy
Translation:Humans Animals
MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. Development. 2016 Mar 01; 143(5):774-9. Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL. PMID: 26811383; PMCID: PMC4813332.

View in: PubMed Mentions: 27 Fields:
Bio Biology Emb Embryology
Translation:Humans Animals Cells
A three-dimensional study of alveologenesis in mouse lung. Dev Biol. 2016 Jan 15; 409(2):429-41. Branchfield K, Li R, Lungova V, Verheyden JM, McCulley D, Sun X. PMID: 26632490; PMCID: PMC4843524.

View in: PubMed Mentions: 82 Fields:
Bio Biology Emb Embryology
Translation:Animals Cells
The pulmonary mesenchyme directs lung development. Curr Opin Genet Dev. 2015 Jun; 32:98-105. McCulley D, Wienhold M, Sun X. PMID: 25796078; PMCID: PMC4763935.

View in: PubMed Mentions: 75 Fields:
Gen Genetics
Translation:Humans Animals
50 years ago in The Journal of Pediatrics: a study of premature infants fed cold formula. J Pediatr. 2012 Oct; 161(4):594. McCulley DJ, Limjoco JJ. PMID: 22999576.

View in: PubMed Mentions: Fields:
Ped Pediatrics
Translation:Humans
Transcription factor pathways and congenital heart disease. Curr Top Dev Biol. 2012; 100:253-77. McCulley DJ, Black BL. PMID: 22449847; PMCID: PMC3684448.

View in: PubMed Mentions: 136 Fields:
Emb Embryology
Translation:Humans Animals Cells
Large-scale discovery of enhancers from human heart tissue. Nat Genet. 2011 Dec 04; 44(1):89-93. May D, Blow MJ, Kaplan T, McCulley DJ, Jensen BC, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Afzal V, Simpson PC, Rubin EM, Black BL, Bristow J, Pennacchio LA, Visel A. PMID: 22138689; PMCID: PMC3246570.

View in: PubMed Mentions: 162 Fields:
Gen Genetics
Translation:Humans Animals Cells
The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development. 2011 Jun; 138(12):2555-65. Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL. PMID: 21610032; PMCID: PMC3100711.

View in: PubMed Mentions: 28 Fields:
Bio Biology Emb Embryology
Translation:Animals Cells
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet. 2010 Sep; 42(9):806-10. Blow MJ, McCulley DJ, Li Z, Zhang T, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Chen F, Afzal V, Bristow J, Ren B, Black BL, Rubin EM, Visel A, Pennacchio LA. PMID: 20729851; PMCID: PMC3138496.

View in: PubMed Mentions: 264 Fields:
Gen Genetics
Translation:Humans Animals Cells
BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn. 2008 Nov; 237(11):3200-9. McCulley DJ, Kang JO, Martin JF, Black BL. PMID: 18924235; PMCID: PMC2728547.

View in: PubMed Mentions: 88 Fields:
Ana Anatomy
Translation:Animals
The transcription factor MEF2C is required for craniofacial development. Dev Cell. 2007 Apr; 12(4):645-52. Verzi MP, Agarwal P, Brown C, McCulley DJ, Schwarz JJ, Black BL. PMID: 17420000; PMCID: PMC1920108.

View in: PubMed Mentions: 67 Fields:
Cel Cell Biology Emb Embryology
Translation:Animals Cells
The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol. 2005 Nov 01; 287(1):134-45. Verzi MP, McCulley DJ, De Val S, Dodou E, Black BL. PMID: 16188249.

View in: PubMed Mentions: 267 Fields:
Bio Biology Emb Embryology
Translation:Animals
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May; 132(10):2451-62. Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. PMID: 15843414.

View in: PubMed Mentions: 97 Fields:
Bio Biology Emb Embryology
Translation:Animals
Subdural empyema and group C Streptococcus. South Med J. 1985 Jan; 78(1):65-6. Layon J, McCulley D. PMID: 2857055.

View in: PubMed Mentions: 1 Fields:
Med Medicine (General)
Translation:Humans Cells
Group A beta-hemolytic streptococcus endocarditis. Am Heart J. 1984 Nov; 108(5):1383-6. Ramirez CA, Naraqi S, McCulley DJ. PMID: 6496302.

View in: PubMed Mentions: 3 Fields:
Car Cardiology
Translation:Humans Cells
Failure of medical therapy in tricuspid endocarditis due to Staphylococcus aureus. Chemotherapy. 1984; 30(6):408-12. Geiseler PJ, Rice TW, McCulley DJ, Lewis SM, Berzins BL. PMID: 6518837.

View in: PubMed Mentions: 1 Fields:
Dru Drug Therapy
Translation:Humans Cells
Increasing incidence of Pseudomonas endocarditis among parenteral drug abusers. Drug Alcohol Depend. 1980 Oct; 6(4):227-30. Rajashekaraiah KR, Dhawan VK, Rice TW, McCulley D, Kallick CA. PMID: 7274000.

View in: PubMed Mentions: 1 Fields:
Sub Substance-Related Disorders
Translation:Humans