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    Tatum Simonson

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0623A
    CA La Jolla 92093
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      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Integrating Physiology and Genomics to Reveal Functional Adaptation in High-Altitude Tibetans
      NIH/NHLBI R00HL118215Jan 17, 2014 - Aug 31, 2018
      Role: Principal Investigator
      Integrating physiology and genomics to reveal functional adaptation in high-altit
      NIH/NHLBI K99HL118215Jan 17, 2014 - Jan 18, 2015
      Role: Principal Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson T, Huff CD. Evolutionary history of Tibetans inferred from whole-genome sequencing. PLoS Genet. 2017 Apr; 13(4):e1006675. PMID: 28448578.
        View in: PubMed
      2. Sá RC, Henderson AC, Simonson T, Arai TJ, Wagner H, Theilmann RJ, Wagner PD, Prisk GK, Hopkins SR. Measurement of the distribution of ventilation-perfusion ratios in the human lung with proton MRI: comparison with the multiple inert-gas elimination technique. J Appl Physiol (1985). 2017 Jul 01; 123(1):136-146. PMID: 28280105.
        View in: PubMed
      3. Wagner PD, Simonson T, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Ge RL. Sea-level haemoglobin concentration is associated with greater exercise capacity in Tibetan males at 4200 m. Exp Physiol. 2015 Nov; 100(11):1256-62. PMID: 26454003.
        View in: PubMed
      4. Ge RL, Simonson T, Gordeuk V, Prchal JT, McClain DA. Metabolic aspects of high-altitude adaptation in Tibetans. Exp Physiol. 2015 Nov; 100(11):1247-55. PMID: 26053282.
        View in: PubMed
      5. Simonson T, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Wagner PD, Ge RL. Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity. J Physiol. 2015 Jul 15; 593(14):3207-18. PMID: 25988759; PMCID: PMC4532538.
      6. Simonson T. Altitude Adaptation: A Glimpse Through Various Lenses. High Alt Med Biol. 2015 Jun; 16(2):125-37. PMID: 26070057; PMCID: PMC4490743.
      7. Simonson T, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL. Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m. Exp Physiol. 2014 Dec 01; 99(12):1624-35. PMID: 25172885; PMCID: PMC4272572.
      8. Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson T, Jorde LB, Kaelin WG, Koivunen P, Prchal JT. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet. 2014 Sep; 46(9):951-6. PMID: 25129147; PMCID: PMC4473257.
      9. Wuren T, Simonson T, Qin G, Xing J, Huff CD, Witherspoon DJ, Jorde LB, Ge RL. Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations. PLoS One. 2014; 9(3):e88252. PMID: 24642866; PMCID: PMC3958363.
      10. Simonson T, Powell FL. Less is more: blunted responses to hypoxia revealed in sea-level Tibetans. J Appl Physiol (1985). 2014 Apr 01; 116(7):711-2. PMID: 24114703.
        View in: PubMed
      11. Xing J, Wuren T, Simonson T, Watkins WS, Witherspoon DJ, Wu W, Qin G, Huff CD, Jorde LB, Ge RL. Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians. PLoS Genet. 2013; 9(7):e1003634. PMID: 23874230; PMCID: PMC3715426.
      12. Ge RL, Simonson T, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA. Metabolic insight into mechanisms of high-altitude adaptation in Tibetans. Mol Genet Metab. 2012 Jun; 106(2):244-7. PMID: 22503288; PMCID: PMC3437309.
      13. Simonson T, McClain DA, Jorde LB, Prchal JT. Genetic determinants of Tibetan high-altitude adaptation. Hum Genet. 2012 Apr; 131(4):527-33. PMID: 22068265.
        View in: PubMed
      14. Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson T, Jorde LB, Guthery SL. Crohn's disease and genetic hitchhiking at IBD5. Mol Biol Evol. 2012 Jan; 29(1):101-11. PMID: 21816865; PMCID: PMC3245542.
      15. Batini C, Ferri G, Destro-Bisol G, Brisighelli F, Luiselli D, Sánchez-Diz P, Rocha J, Simonson T, Brehm A, Montano V, Elwali NE, Spedini G, D'Amato ME, Myres N, Ebbesen P, Comas D, Capelli C. Signatures of the preagricultural peopling processes in sub-Saharan Africa as revealed by the phylogeography of early Y chromosome lineages. Mol Biol Evol. 2011 Sep; 28(9):2603-13. PMID: 21478374.
        View in: PubMed
      16. Huff CD, Witherspoon DJ, Simonson T, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB. Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res. 2011 May; 21(5):768-74. PMID: 21324875; PMCID: PMC3083094.
      17. Simonson T, Xing J, Barrett R, Jerah E, Loa P, Zhang Y, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B, Jorde LB. Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes. PLoS One. 2011 Jan 31; 6(1):e16338. PMID: 21305013; PMCID: PMC3031551.
      18. Xing J, Watkins WS, Shlien A, Walker E, Huff CD, Witherspoon DJ, Zhang Y, Simonson T, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB. Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping. Genomics. 2010 Oct; 96(4):199-210. PMID: 20643205; PMCID: PMC2945611.
      19. Simonson T, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R. Genetic evidence for high-altitude adaptation in Tibet. Science. 2010 Jul 02; 329(5987):72-5. PMID: 20466884.
        View in: PubMed
      20. Simonson T, Zhang Y, Huff CD, Xing J, Watkins WS, Witherspoon DJ, Woodward SR, Jorde LB. Limited distribution of a cardiomyopathy-associated variant in India. Ann Hum Genet. 2010 Mar; 74(2):184-8. PMID: 20201939; PMCID: PMC2901538.
      21. Lorenzo VF, Yang Y, Simonson T, Nussenzveig R, Jorde LB, Prchal JT, Ge RL. Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family. Blood Cells Mol Dis. 2009 Nov-Dec; 43(3):221-5. PMID: 19481479; PMCID: PMC3506116.
      22. Simonson T, Okinaka RT, Wang B, Easterday WR, Huynh L, U'Ren JM, Dukerich M, Zanecki SR, Kenefic LJ, Beaudry J, Schupp JM, Pearson T, Wagner DM, Hoffmaster A, Ravel J, Keim P. Bacillus anthracis in China and its relationship to worldwide lineages. BMC Microbiol. 2009 Apr 15; 9:71. PMID: 19368722; PMCID: PMC2674057.
      23. Van Ert MN, Easterday WR, Huynh LY, Okinaka RT, Hugh-Jones ME, Ravel J, Zanecki SR, Pearson T, Simonson T, U'Ren JM, Kachur SM, Leadem-Dougherty RR, Rhoton SD, Zinser G, Farlow J, Coker PR, Smith KL, Wang B, Kenefic LJ, Fraser-Liggett CM, Wagner DM, Keim P. Global genetic population structure of Bacillus anthracis. PLoS One. 2007 May 23; 2(5):e461. PMID: 17520020; PMCID: PMC1866244.
      24. Van Ert MN, Easterday WR, Simonson T, U'Ren JM, Pearson T, Kenefic LJ, Busch JD, Huynh LY, Dukerich M, Trim CB, Beaudry J, Welty-Bernard A, Read T, Fraser CM, Ravel J, Keim P. Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain. J Clin Microbiol. 2007 Jan; 45(1):47-53. PMID: 17093023; PMCID: PMC1828967.
      25. U'Ren JM, Van Ert MN, Schupp JM, Easterday WR, Simonson T, Okinaka RT, Pearson T, Keim P. Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol. 2005 Nov; 43(11):5771-4. PMID: 16272516; PMCID: PMC1287822.
      26. Easterday WR, Van Ert MN, Simonson T, Wagner DM, Kenefic LJ, Allender CJ, Keim P. Use of single nucleotide polymorphisms in the plcR gene for specific identification of Bacillus anthracis. J Clin Microbiol. 2005 Apr; 43(4):1995-7. PMID: 15815042; PMCID: PMC1081367.
      27. Van Ert MN, Hofstadler SA, Jiang Y, Busch JD, Wagner DM, Drader JJ, Ecker DJ, Hannis JC, Huynh LY, Schupp JM, Simonson T, Keim P. Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis. Biotechniques. 2004 Oct; 37(4):642-4, 646, 648 passim. PMID: 15517976.
        View in: PubMed
      28. Pearson T, Busch JD, Ravel J, Read TD, Rhoton SD, U'Ren JM, Simonson T, Kachur SM, Leadem RR, Cardon ML, Van Ert MN, Huynh LY, Fraser CM, Keim P. Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13536-41. PMID: 15347815; PMCID: PMC518758.