Tatum Simonson

Title(s)Assistant Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Utah, Salt Lake City, UTPhD12/2011Human Genetics
    Collapse Awards and Honors
    National Geographic2018Explorer Award
    American Physiological Society2017Giles F. Filley Memorial Award
    Francis Family Foundation2013Parker B. Francis Fellowship
    American Physiological Society2012Physiological Genomics Fellowship
    University of Utah2012James W. Prahl Award, Outstanding PhD in Biomedical Sciences, School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Respiratory and genomic contributions to adaptive/maladaptive hypoxia responses
    NIH R01HL145470May 10, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Integrating Physiology and Genomics to Reveal Functional Adaptation in High-Altitude Tibetans
    NIH R00HL118215Jan 17, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Integrating physiology and genomics to reveal functional adaptation in high-altit
    NIH K99HL118215Jan 17, 2014 - Jan 18, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021 Mar 10. Jain PP, Zhao T, Xiong M, Song S, Lai N, Zheng Q, Chen J, Carr SG, Babicheva A, Izadi A, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Simonson T, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Makino A, Yuan JX. PMID: 33694155.
      View in: PubMed   Mentions:    Fields:    
    2. Impacts of Changes in Atmospheric O2 on Human Physiology. Is There a Basis for Concern? Front Physiol. 2021; 12:571137. Keeling RF, Powell FL, Shaffer G, Robbins PA, Simonson TS. PMID: 33737880.
      View in: PubMed   Mentions:
    3. Silent hypoxaemia in COVID-19 patients. J Physiol. 2021 02; 599(4):1057-1065. Simonson TS, Baker TL, Banzett RB, Bishop T, Dempsey JA, Feldman JL, Guyenet PG, Hodson EJ, Mitchell GS, Moya EA, Nokes BT, Orr JE, Owens RL, Poulin M, Rawling JM, Schmickl CN, Watters JJ, Younes M, Malhotra A. PMID: 33347610.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    4. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020968531. Romanoski CE, Qi X, Sangam S, Vanderpool RR, Stearman RS, Conklin A, Gonzalez-Garay M, Rischard F, Ayon RJ, Wang J, Simonson T, Babicheva A, Shi Y, Tang H, Makino A, Kanthi Y, Geraci MW, Garcia JGN, Yuan JX, Desai AA. PMID: 33343881.
      View in: PubMed   Mentions:
    5. Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension. Pulm Circ. 2020 Jul-Sep; 10(3):2045894020948470. Wu K, Tang H, Lin R, Carr SG, Wang Z, Babicheva A, Ayon RJ, Jain PP, Xiong M, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Valdez-Jasso D, Simonson TS, Desai AA, Garcia JGN, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 33294172.
      View in: PubMed   Mentions:
    6. Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia. Front Physiol. 2020; 11:886. Tift MS, Alves de Souza RW, Weber J, Heinrich EC, Villafuerte FC, Malhotra A, Otterbein LE, Simonson TS. PMID: 32792988.
      View in: PubMed   Mentions:
    7. Cross-Species Insights Into Genomic Adaptations to Hypoxia. Front Genet. 2020; 11:743. Pamenter ME, Hall JE, Tanabe Y, Simonson TS. PMID: 32849780.
      View in: PubMed   Mentions:
    8. Seq-ing Higher Ground: Functional Investigation of Adaptive Variation Associated With High-Altitude Adaptation. Front Genet. 2020; 11:471. Hall JE, Lawrence ES, Simonson TS, Fox K. PMID: 32528523.
      View in: PubMed   Mentions:
    9. Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women. Front Physiol. 2020; 11:437. Heinrich EC, Orr JE, Gilbertson D, Anza-Ramirez C, DeYoung PN, Djokic MA, Corante N, Vizcardo-Galindo G, Macarlupu JL, Gaio E, Powell FL, Malhotra A, Villafuerte FC, Simonson TS. PMID: 32435207.
      View in: PubMed   Mentions:
    10. Variability in hypoxic response: Could genetics play a role? J Physiol. 2020 05; 598(10):1805-1806. Simonson TS, Malhotra A. PMID: 32281106.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Neuronal HIF-1a in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia. J Physiol. 2020 05; 598(10):2021-2034. Moya EA, Go A, Kim CB, Fu Z, Simonson TS, Powell FL. PMID: 32026480.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. PLoS One. 2019; 14(6):e0217089. Heinrich EC, Djokic MA, Gilbertson D, DeYoung PN, Bosompra NO, Wu L, Anza-Ramirez C, Orr JE, Powell FL, Malhotra A, Simonson TS. PMID: 31188839.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. Genetic variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans. Ann Hum Genet. 2019 05; 83(3):171-176. Heinrich EC, Wu L, Lawrence ES, Cole AM, Anza-Ramirez C, Villafuerte FC, Simonson TS. PMID: 30719713.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. Giants in Chest Medicine: Emeritus Professor Peter D. Wagner, MD. Chest. 2019 01; 155(1):9-11. Simonson TS. PMID: 30616739.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals. High Alt Med Biol. 2018 06; 19(2):178-184. Orr JE, Heinrich EC, Djokic M, Gilbertson D, Deyoung PN, Anza-Ramirez C, Villafuerte FC, Powell FL, Malhotra A, Simonson T. PMID: 29641294.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Evolutionary history of Tibetans inferred from whole-genome sequencing. PLoS Genet. 2017 04; 13(4):e1006675. Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD. PMID: 28448578.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    17. Measurement of the distribution of ventilation-perfusion ratios in the human lung with proton MRI: comparison with the multiple inert-gas elimination technique. J Appl Physiol (1985). 2017 Jul 01; 123(1):136-146. Sá RC, Henderson AC, Simonson T, Arai TJ, Wagner H, Theilmann RJ, Wagner PD, Prisk GK, Hopkins SR. PMID: 28280105.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Oxygen transport adaptations to exercise in native highland populations. Exp Physiol. 2015 Nov; 100(11):1231-2. Simonson TS, Wagner PD. PMID: 26575339.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Metabolic aspects of high-altitude adaptation in Tibetans. Exp Physiol. 2015 Nov; 100(11):1247-55. Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA. PMID: 26053282.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    20. Altitude Adaptation: A Glimpse Through Various Lenses. High Alt Med Biol. 2015 Jun; 16(2):125-37. Simonson TS. PMID: 26070057.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    21. Reply: To PMID 25172885. Exp Physiol. 2015 Mar; 100(3):342. Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL. PMID: 25720665.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m. Exp Physiol. 2014 Dec 01; 99(12):1624-35. Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL. PMID: 25172885.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet. 2014 Sep; 46(9):951-6. Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG, Koivunen P, Prchal JT. PMID: 25129147.
      View in: PubMed   Mentions: 132     Fields:    Translation:Humans
    24. Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations. PLoS One. 2014; 9(3):e88252. Wuren T, Simonson TS, Qin G, Xing J, Huff CD, Witherspoon DJ, Jorde LB, Ge RL. PMID: 24642866.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    25. Less is more: blunted responses to hypoxia revealed in sea-level Tibetans. J Appl Physiol (1985). 2014 Apr 01; 116(7):711-2. Simonson TS, Powell FL. PMID: 24114703.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians. PLoS Genet. 2013; 9(7):e1003634. Xing J, Wuren T, Simonson TS, Watkins WS, Witherspoon DJ, Wu W, Qin G, Huff CD, Jorde LB, Ge RL. PMID: 23874230.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    27. Metabolic insight into mechanisms of high-altitude adaptation in Tibetans. Mol Genet Metab. 2012 Jun; 106(2):244-7. Ge RL, Simonson TS, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA. PMID: 22503288.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    28. Genetic determinants of Tibetan high-altitude adaptation. Hum Genet. 2012 Apr; 131(4):527-33. Simonson TS, McClain DA, Jorde LB, Prchal JT. PMID: 22068265.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    29. Crohn's disease and genetic hitchhiking at IBD5. Mol Biol Evol. 2012 Jan; 29(1):101-11. Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL. PMID: 21816865.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    30. Signatures of the preagricultural peopling processes in sub-Saharan Africa as revealed by the phylogeography of early Y chromosome lineages. Mol Biol Evol. 2011 Sep; 28(9):2603-13. Batini C, Ferri G, Destro-Bisol G, Brisighelli F, Luiselli D, Sánchez-Diz P, Rocha J, Simonson T, Brehm A, Montano V, Elwali NE, Spedini G, D'Amato ME, Myres N, Ebbesen P, Comas D, Capelli C. PMID: 21478374.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    31. Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res. 2011 May; 21(5):768-74. Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB. PMID: 21324875.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    32. Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes. PLoS One. 2011 Jan 31; 6(1):e16338. Simonson TS, Xing J, Barrett R, Jerah E, Loa P, Zhang Y, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B, Jorde LB. PMID: 21305013.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    33. Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping. Genomics. 2010 Oct; 96(4):199-210. Xing J, Watkins WS, Shlien A, Walker E, Huff CD, Witherspoon DJ, Zhang Y, Simonson TS, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB. PMID: 20643205.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    34. Genetic evidence for high-altitude adaptation in Tibet. Science. 2010 Jul 02; 329(5987):72-5. Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R. PMID: 20466884.
      View in: PubMed   Mentions: 397     Fields:    Translation:HumansCells
    35. Limited distribution of a cardiomyopathy-associated variant in India. Ann Hum Genet. 2010 Mar; 74(2):184-8. Simonson TS, Zhang Y, Huff CD, Xing J, Watkins WS, Witherspoon DJ, Woodward SR, Jorde LB. PMID: 20201939.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    36. Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family. Blood Cells Mol Dis. 2009 Nov-Dec; 43(3):221-5. Lorenzo VF, Yang Y, Simonson TS, Nussenzveig R, Jorde LB, Prchal JT, Ge RL. PMID: 19481479.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    37. Bacillus anthracis in China and its relationship to worldwide lineages. BMC Microbiol. 2009 Apr 15; 9:71. Simonson TS, Okinaka RT, Wang B, Easterday WR, Huynh L, U'Ren JM, Dukerich M, Zanecki SR, Kenefic LJ, Beaudry J, Schupp JM, Pearson T, Wagner DM, Hoffmaster A, Ravel J, Keim P. PMID: 19368722.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    38. Global genetic population structure of Bacillus anthracis. PLoS One. 2007 May 23; 2(5):e461. Van Ert MN, Easterday WR, Huynh LY, Okinaka RT, Hugh-Jones ME, Ravel J, Zanecki SR, Pearson T, Simonson TS, U'Ren JM, Kachur SM, Leadem-Dougherty RR, Rhoton SD, Zinser G, Farlow J, Coker PR, Smith KL, Wang B, Kenefic LJ, Fraser-Liggett CM, Wagner DM, Keim P. PMID: 17520020.
      View in: PubMed   Mentions: 142     Fields:    Translation:Cells
    39. Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain. J Clin Microbiol. 2007 Jan; 45(1):47-53. Van Ert MN, Easterday WR, Simonson TS, U'Ren JM, Pearson T, Kenefic LJ, Busch JD, Huynh LY, Dukerich M, Trim CB, Beaudry J, Welty-Bernard A, Read T, Fraser CM, Ravel J, Keim P. PMID: 17093023.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    40. Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol. 2005 Nov; 43(11):5771-4. U'Ren JM, Van Ert MN, Schupp JM, Easterday WR, Simonson TS, Okinaka RT, Pearson T, Keim P. PMID: 16272516.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    41. Use of single nucleotide polymorphisms in the plcR gene for specific identification of Bacillus anthracis. J Clin Microbiol. 2005 Apr; 43(4):1995-7. Easterday WR, Van Ert MN, Simonson TS, Wagner DM, Kenefic LJ, Allender CJ, Keim P. PMID: 15815042.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    42. Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis. Biotechniques. 2004 Oct; 37(4):642-4, 646, 648 passim. Van Ert MN, Hofstadler SA, Jiang Y, Busch JD, Wagner DM, Drader JJ, Ecker DJ, Hannis JC, Huynh LY, Schupp JM, Simonson TS, Keim P. PMID: 15517976.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    43. Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13536-41. Pearson T, Busch JD, Ravel J, Read TD, Rhoton SD, U'Ren JM, Simonson TS, Kachur SM, Leadem RR, Cardon ML, Van Ert MN, Huynh LY, Fraser CM, Keim P. PMID: 15347815.
      View in: PubMed   Mentions: 126     Fields:    Translation:Cells
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