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    Wesley Thompson

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    DepartmentFamily Medicine and Public Health
    Address9500 Gilman Drive #0725
    CA La Jolla 92093
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      Dr. Thompson earned his Ph.D. in Statistics from Rutgers University in 2003, with a focus on statistical methods for longitudinal data analysis. He was appointed Assistant Professor of Statistics and Psychiatry at the University of Pittsburgh in 2005, where he received a five year NIH K25 Career Development Award to develop novel methods for studying co-variation in brain function and depression. Dr. Thompson joined the UCSD Department of Psychiatry in 2008. His current work involves Bayesian semi-parametric and mixture models with applications to (i) improving effect size estimation, replication, and prediction in genome-wide association studies, (ii) predicting onset of illness from multivariate biomarker trajectories, (iii) applications of functional data analysis to functional MRI data.

      Research Interests

      Dr. Thompson's research focuses on the development and application of semi-parametric Bayesian hierarchical and mixture models for multivariate data, with applications to diverse areas of biological psychiatry. These applications include: 1) human brain imaging and other biological markers of mental illness; 2) improved replication and polygenic risk score estimation from genome-wide association studies; 3) estimation of developmental trajectories and prediction of outcomes from incomplete longitudinal data; and 4) prediction of clinical outcomes from intensively sampled longitudinal data.

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      Polygenicity, Pleiotrophy and Power: Novel Statistical Methods for Gene Discovery
      NIH/NIGMS R01GM104400Jun 5, 2014 - May 31, 2018
      Role: Principal Investigator
      Modeling Dynamic Covariation of Brain Function, Health and Symptoms in Depression
      NIH/NIMH K25MH076981Apr 1, 2006 - Jul 1, 2011
      Role: Principal Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chen CH, Wang Y, Lo MT, Schork A, Fan CC, Holland D, Kauppi K, Smeland OB, Djurovic S, Sanyal N, Hibar DP, Thompson PM, Thompson W, Andreassen OA, Dale AM. Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure. Sci Rep. 2017 Nov 16; 7(1):15736. PMID: 29147026.
        View in: PubMed
      2. Smeland OB, Frei O, Kauppi K, Hill WD, Li W, Wang Y, Krull F, Bettella F, Eriksen JA, Witoelar A, Davies G, Fan CC, Thompson W, Lam M, Lencz T, Chen CH, Ueland T, Jönsson EG, Djurovic S, Deary IJ, Dale AM, Andreassen OA. Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function. JAMA Psychiatry. 2017 Jul 26. PMID: 28746715.
        View in: PubMed
      3. Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson W, Hernandez DG, Djurovic S, Schork AJ, Bettella F, Ellinghaus D, Franke A, Lie BA, McEvoy LK, Karlsen TH, Lesage S, Morris HR, Brice A, Wood NW, Heutink P, Hardy J, Singleton AB, Dale AM, Gasser T, Andreassen OA, Sharma M. Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. JAMA Neurol. 2017 Jul 01; 74(7):780-792. PMID: 28586827.
        View in: PubMed
      4. Le Hellard S, Wang Y, Witoelar A, Zuber V, Bettella F, Hugdahl K, Espeseth T, Steen VM, Melle I, Desikan R, Schork AJ, Thompson W, Dale AM, Djurovic S, Andreassen OA. Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment. Schizophr Bull. 2017 05 01; 43(3):654-664. PMID: 27338279.
        View in: PubMed
      5. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson W, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258. PMID: 28323831.
        View in: PubMed
      6. Sullivan EV, Brumback T, Tapert SF, Prouty D, Fama R, Thompson W, Brown SA, Cummins K, Colrain IM, Baker FC, Clark DB, Chung T, De Bellis MD, Hooper SR, Nagel BJ, Nichols BN, Chu W, Kwon D, Pohl KM, Pfefferbaum A. Effects of prior testing lasting a full year in NCANDA adolescents: Contributions from age, sex, socioeconomic status, ethnicity, site, family history of alcohol or drug abuse, and baseline performance. Dev Cogn Neurosci. 2017 Apr; 24:72-83. PMID: 28214667.
        View in: PubMed
      7. Srinivasan S, Bettella F, Hassani S, Wang Y, Witoelar A, Schork AJ, Thompson W, Collier DA, Desikan RS, Melle I, Dale AM, Djurovic S, Andreassen OA. Probing the Association between Early Evolutionary Markers and Schizophrenia. PLoS One. 2017; 12(1):e0169227. PMID: 28081145.
        View in: PubMed
      8. Depp CA, Thompson W, Frank E, Swartz HA. Prediction of near-term increases in suicidal ideation in recently depressed patients with bipolar II disorder using intensive longitudinal data. J Affect Disord. 2017 Jan 15; 208:363-368. PMID: 27810719.
        View in: PubMed
      9. Zuber V, Marconett CN, Shi J, Hua X, Wheeler W, Yang C, Song L, Dale AM, Laplana M, Risch A, Witoelar A, Thompson W, Schork AJ, Bettella F, Wang Y, Djurovic S, Zhou B, Borok Z, van der Heijden HF, de Graaf J, Swinkels D, Aben KK, McKay J, Hung RJ, Bikeböller H, Stevens VL, Albanes D, Caporaso NE, Han Y, Wei Y, Panadero MA, Mayordomo JI, Christiani DC, Kiemeney L, Andreassen OA, Houlston R, Amos CI, Chatterjee N, Laird-Offringa IA, Mills IG, Landi MT. Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. J Natl Cancer Inst. 2016 Dec; 108(12). PMID: 27565901.
        View in: PubMed
      10. Thomas ML, Kaufmann CN, Palmer BW, Depp CA, Martin AS, Glorioso DK, Thompson W, Jeste DV. Paradoxical Trend for Improvement in Mental Health With Aging: A Community-Based Study of 1,546 Adults Aged 21-100 Years. J Clin Psychiatry. 2016 Aug; 77(8):e1019-25. PMID: 27561149.
        View in: PubMed
      11. Yokoyama JS, Wang Y, Schork AJ, Thompson W, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 Jun 01; 73(6):691-7. PMID: 27088644; PMCID: PMC4905783.
      12. Falahpour M, Thompson W, Abbott AE, Jahedi A, Mulvey ME, Datko M, Liu TT, Müller RA. Underconnected, But Not Broken? Dynamic Functional Connectivity MRI Shows Underconnectivity in Autism Is Linked to Increased Intra-Individual Variability Across Time. Brain Connect. 2016 Jun; 6(5):403-14. PMID: 26973154; PMCID: PMC4913487 [Available on 06/01/17].
      13. Pohl KM, Sullivan EV, Rohlfing T, Chu W, Kwon D, Nichols BN, Zhang Y, Brown SA, Tapert SF, Cummins K, Thompson W, Brumback T, Colrain IM, Baker FC, Prouty D, De Bellis MD, Voyvodic JT, Clark DB, Schirda C, Nagel BJ, Pfefferbaum A. Harmonizing DTI measurements across scanners to examine the development of white matter microstructure in 803 adolescents of the NCANDA study. Neuroimage. 2016 Apr 15; 130:194-213. PMID: 26872408; PMCID: PMC4808415 [Available on 04/15/17].
      14. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Franz CE, Jak AJ, Lyons MJ, Neale MC, Rinker DA, Thompson W, Tsuang MT, Dale AM, Kremen WS. Is bigger always better? The importance of cortical configuration with respect to cognitive ability. Neuroimage. 2016 Apr 01; 129:356-366. PMID: 26827810; PMCID: PMC4838639 [Available on 04/01/17].
      15. Sullivan EV, Brumback T, Tapert SF, Fama R, Prouty D, Brown SA, Cummins K, Thompson W, Colrain IM, Baker FC, De Bellis MD, Hooper SR, Clark DB, Chung T, Nagel BJ, Nichols BN, Rohlfing T, Chu W, Pohl KM, Pfefferbaum A. Cognitive, emotion control, and motor performance of adolescents in the NCANDA study: Contributions from alcohol consumption, age, sex, ethnicity, and family history of addiction. Neuropsychology. 2016 May; 30(4):449-73. PMID: 26752122.
        View in: PubMed
      16. Thompson W, Wang Y, Schork AJ, Witoelar A, Zuber V, Xu S, Werge T, Holland D, Andreassen OA, Dale AM. An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies. PLoS Genet. 2015 Dec; 11(12):e1005717. PMID: 26714184.
        View in: PubMed
      17. Reppe S, Wang Y, Thompson W, McEvoy LK, Schork AJ, Zuber V, LeBlanc M, Bettella F, Mills IG, Desikan RS, Djurovic S, Gautvik KM, Dale AM, Andreassen OA. Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci. PLoS One. 2015; 10(12):e0144531. PMID: 26695485; PMCID: PMC4687843.
      18. Schork AJ, Wang Y, Thompson W, Dale AM, Andreassen OA. New statistical approaches exploit the polygenic architecture of schizophrenia--implications for the underlying neurobiology. Curr Opin Neurobiol. 2016 Feb; 36:89-98. PMID: 26555806.
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      19. Andreassen OA, Thompson W, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P, Roddey JC, Chen CH, McEvoy L, Desikan RS, Djurovic S, Dale AM. Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genet. 2015 Nov; 11(11):e1005544. PMID: 26540268; PMCID: PMC4634985.
      20. Fjell AM, Grydeland H, Krogsrud SK, Amlien I, Rohani DA, Ferschmann L, Storsve AB, Tamnes CK, Sala-Llonch R, Due-Tønnessen P, Bjørnerud A, Sølsnes AE, Håberg AK, Skranes J, Bartsch H, Chen CH, Thompson W, Panizzon MS, Kremen WS, Dale AM, Walhovd KB. Development and aging of cortical thickness correspond to genetic organization patterns. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15462-7. PMID: 26575625; PMCID: PMC4687601.
      21. Brown SA, Brumback T, Tomlinson K, Cummins K, Thompson W, Nagel BJ, De Bellis MD, Hooper SR, Clark DB, Chung T, Hasler BP, Colrain IM, Baker FC, Prouty D, Pfefferbaum A, Sullivan EV, Pohl KM, Rohlfing T, Nichols BN, Chu W, Tapert SF. The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): A Multisite Study of Adolescent Development and Substance Use. J Stud Alcohol Drugs. 2015 Nov; 76(6):895-908. PMID: 26562597; PMCID: PMC4712659 [Available on 11/01/16].
      22. Srinivasan S, Bettella F, Mattingsdal M, Wang Y, Witoelar A, Schork AJ, Thompson W, Zuber V, Winsvold BS, Zwart JA, Collier DA, Desikan RS, Melle I, Werge T, Dale AM, Djurovic S, Andreassen OA. Genetic Markers of Human Evolution Are Enriched in Schizophrenia. Biol Psychiatry. 2016 Aug 15; 80(4):284-92. PMID: 26681495.
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      23. LeBlanc M, Zuber V, Andreassen BK, Witoelar A, Zeng L, Bettella F, Wang Y, McEvoy LK, Thompson W, Schork AJ, Reppe S, Barrett-Connor E, Ligthart S, Dehghan A, Gautvik KM, Nelson CP, Schunkert H, Samani NJ, Ridker PM, Chasman DI, Aukrust P, Djurovic S, Frigessi A, Desikan RS, Dale AM, Andreassen OA. Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors. Circ Res. 2016 Jan 08; 118(1):83-94. PMID: 26487741.
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      24. Pfefferbaum A, Rohlfing T, Pohl KM, Lane B, Chu W, Kwon D, Nolan Nichols B, Brown SA, Tapert SF, Cummins K, Thompson W, Brumback T, Meloy MJ, Jernigan TL, Dale A, Colrain IM, Baker FC, Prouty D, De Bellis MD, Voyvodic JT, Clark DB, Luna B, Chung T, Nagel BJ, Sullivan EV. Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking. Cereb Cortex. 2016 Oct; 26(10):4101-21. PMID: 26408800.
        View in: PubMed
      25. Newman E, Thompson W, Bartsch H, Hagler DJ, Chen CH, Brown TT, Kuperman JM, McCabe C, Chung Y, Libiger O, Akshoomoff N, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Murray SS, Sowell ER, Schork N, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM, Jernigan TL. Anxiety is related to indices of cortical maturation in typically developing children and adolescents. Brain Struct Funct. 2016 Jul; 221(6):3013-25. PMID: 26183468.
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      26. Max JE, Wilde EA, Bigler ED, Hanten G, Dennis M, Schachar RJ, Saunders AE, Ewing-Cobbs L, Chapman SB, Thompson W, Yang TT, Levin HS. Personality Change Due to Traumatic Brain Injury in Children and Adolescents: Neurocognitive Correlates. J Neuropsychiatry Clin Neurosci. 2015; 27(4):272-9. PMID: 26185905; PMCID: PMC4618043.
      27. Andreassen OA, Desikan RS, Wang Y, Thompson W, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM. Correction: Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms. PLoS One. 2015; 10(5):e0128048. PMID: 25978331; PMCID: PMC4433198.
      28. Jernigan TL, Brown TT, Hagler DJ, Akshoomoff N, Bartsch H, Newman E, Thompson W, Bloss CS, Murray SS, Schork N, Kennedy DN, Kuperman JM, McCabe C, Chung Y, Libiger O, Maddox M, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Sowell ER, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM. The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. Neuroimage. 2016 Jan 01; 124(Pt B):1149-54. PMID: 25937488; PMCID: PMC4628902 [Available on 01/01/17].
      29. Goulart LF, Bettella F, Sønderby IE, Schork AJ, Thompson W, Mattingsdal M, Steen VM, Zuber V, Wang Y, Dale AM, Andreassen OA, Djurovic S. MicroRNAs enrichment in GWAS of complex human phenotypes. BMC Genomics. 2015 Apr 16; 16:304. PMID: 25884492; PMCID: PMC4437677.
      30. Desikan RS, Schork AJ, Wang Y, Thompson W, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. PMID: 25862742; PMCID: PMC4677995.
      31. Andreassen OA, Desikan RS, Wang Y, Thompson W, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Mills I, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM. Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLoS One. 2015; 10(4):e0123057. PMID: 25853426; PMCID: PMC4390360.
      32. Rosen O, Thompson W. Bayesian semiparametric copula estimation with application to psychiatric genetics. Biom J. 2015 May; 57(3):468-84. PMID: 25664559.
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      33. Docherty AR, Hagler DJ, Panizzon MS, Neale MC, Eyler LT, Fennema-Notestine C, Franz CE, Jak A, Lyons MJ, Rinker DA, Thompson W, Tsuang MT, Dale AM, Kremen WS. Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability? Neuroimage. 2015 Feb 01; 106:154-60. PMID: 25433211; PMCID: PMC4313767.
      34. Depp CA, Ceglowski J, Wang VC, Yaghouti F, Mausbach BT, Thompson W, Granholm EL. Augmenting psychoeducation with a mobile intervention for bipolar disorder: a randomized controlled trial. J Affect Disord. 2015 Mar 15; 174:23-30. PMID: 25479050; PMCID: PMC4339469.
      35. Jak AJ, Panizzon MS, Spoon KM, Fennema-Notestine C, Franz CE, Thompson W, Jacobson KC, Xian H, Eyler LT, Vuoksimaa E, Toomey R, Lyons MJ, Neale MC, Tsuang MT, Dale AM, Kremen WS. Hippocampal atrophy varies by neuropsychologically defined MCI among men in their 50s. Am J Geriatr Psychiatry. 2015 May; 23(5):456-65. PMID: 25306196; PMCID: PMC4345132.
      36. Moore RC, Eyler LT, Mausbach BT, Zlatar ZZ, Thompson W, Peavy G, Fazeli PL, Jeste DV. Complex interplay between health and successful aging: role of perceived stress, resilience, and social support. Am J Geriatr Psychiatry. 2015 Jun; 23(6):622-32. PMID: 25217186; PMCID: PMC4329284.
      37. Johnson DC, Thom NJ, Stanley EA, Haase L, Simmons AN, Shih PA, Thompson W, Potterat EG, Minor TR, Paulus MP. Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment. Am J Psychiatry. 2014 Aug; 171(8):844-53. PMID: 24832476; PMCID: PMC4458258.
      38. Thompson W, Gershon A, O'Hara R, Bernert RA, Depp CA. The prediction of study-emergent suicidal ideation in bipolar disorder: a pilot study using ecological momentary assessment data. Bipolar Disord. 2014 Nov; 16(7):669-77. PMID: 24903771; PMCID: PMC4213287.
      39. Andreassen OA, Zuber V, Thompson W, Schork AJ, Bettella F, Djurovic S, Desikan RS, Mills IG, Dale AM. Shared common variants in prostate cancer and blood lipids. Int J Epidemiol. 2014 Aug; 43(4):1205-14. PMID: 24786909; PMCID: PMC4121563.
      40. Moore RC, Martin AS, Kaup AR, Thompson W, Peters ME, Jeste DV, Golshan S, Eyler LT. From suffering to caring: a model of differences among older adults in levels of compassion. Int J Geriatr Psychiatry. 2015 Feb; 30(2):185-91. PMID: 24733732; PMCID: PMC4198513.
      41. Zablocki RW, Schork AJ, Levine RA, Andreassen OA, Dale AM, Thompson W. Covariate-modulated local false discovery rate for genome-wide association studies. Bioinformatics. 2014 Aug 01; 30(15):2098-104. PMID: 24711653; PMCID: PMC4103587.
      42. Kremen WS, Jak AJ, Panizzon MS, Spoon KM, Franz CE, Thompson W, Jacobson KC, Vasilopoulos T, Vuoksimaa E, Xian H, Toomey R, Lyons MJ. Authors' response to: commentary by Johnson et al. Int J Epidemiol. 2014 Apr; 43(2):612-3. PMID: 24760875; PMCID: PMC3997381.
      43. Bartsch H, Thompson W, Jernigan TL, Dale AM. A web-portal for interactive data exploration, visualization, and hypothesis testing. Front Neuroinform. 2014; 8:25. PMID: 24723882; PMCID: PMC3972454.
      44. Wang V, Depp CA, Ceglowski J, Thompson W, Rock D, Jeste DV. Sexual health and function in later life: a population-based study of 606 older adults with a partner. Am J Geriatr Psychiatry. 2015 Mar; 23(3):227-33. PMID: 24840610.
        View in: PubMed
      45. Zlatar ZZ, Moore RC, Palmer BW, Thompson W, Jeste DV. Cognitive complaints correlate with depression rather than concurrent objective cognitive impairment in the successful aging evaluation baseline sample. J Geriatr Psychiatry Neurol. 2014 Sep; 27(3):181-7. PMID: 24614203; PMCID: PMC4255945.
      46. Franz CE, Lyons MJ, Spoon KM, Hauger RL, Jacobson KC, Lohr JB, McKenzie R, Panizzon MS, Thompson W, Tsuang MT, Vasilopoulos T, Vuoksimaa E, Xian H, Kremen WS. Post-traumatic stress symptoms and adult attachment: a 24-year longitudinal study. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1603-12. PMID: 24636844; PMCID: PMC4138283.
      47. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Fischl B, Franz CE, Jak A, Lyons MJ, Neale MC, Rinker DA, Thompson W, Tsuang MT, Dale AM, Kremen WS. The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness. Cereb Cortex. 2015 Aug; 25(8):2127-37. PMID: 24554725; PMCID: PMC4494025.
      48. Desikan RS, Thompson W, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. The role of clusterin in amyloid-ß-associated neurodegeneration. JAMA Neurol. 2014 Feb; 71(2):180-7. PMID: 24378367; PMCID: PMC4118752.
      49. Andreassen OA, McEvoy LK, Thompson W, Wang Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E, Gautvik K, Aukrust P, Karlsen TH, Djurovic S, Desikan RS, Dale AM. Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes. Hypertension. 2014 Apr; 63(4):819-26. PMID: 24396023; PMCID: PMC3984909.
      50. Choi J, Anderson SJ, Richards TJ, Thompson W. Prediction of transplant-free survival in idiopathic pulmonary fibrosis patients using joint models for event times and mixed multivariate longitudinal data. J Appl Stat. 2014 Jan 01; 41(10):2192-2205. PMID: 25214700.
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      51. Kremen WS, Jak AJ, Panizzon MS, Spoon KM, Franz CE, Thompson W, Jacobson KC, Vasilopoulos T, Vuoksimaa E, Xian H, Toomey R, Lyons MJ. Early identification and heritability of mild cognitive impairment. Int J Epidemiol. 2014 Apr; 43(2):600-10. PMID: 24370560; PMCID: PMC3997374.
      52. Andreassen OA, Thompson W, Dale AM. Boosting the power of schizophrenia genetics by leveraging new statistical tools. Schizophr Bull. 2014 Jan; 40(1):13-7. PMID: 24319118; PMCID: PMC3885310.
      53. Eyler LT, Vuoksimaa E, Panizzon MS, Fennema-Notestine C, Neale MC, Chen CH, Jak A, Franz CE, Lyons MJ, Thompson W, Spoon KM, Fischl B, Dale AM, Kremen WS. Conceptual and data-based investigation of genetic influences and brain asymmetry: a twin study of multiple structural phenotypes. J Cogn Neurosci. 2014 May; 26(5):1100-17. PMID: 24283492; PMCID: PMC3999438.
      54. Akshoomoff N, Newman E, Thompson W, McCabe C, Bloss CS, Chang L, Amaral DG, Casey BJ, Ernst TM, Frazier JA, Gruen JR, Kaufmann WE, Kenet T, Kennedy DN, Libiger O, Mostofsky S, Murray SS, Sowell ER, Schork N, Dale AM, Jernigan TL. The NIH Toolbox Cognition Battery: results from a large normative developmental sample (PING). Neuropsychology. 2014 Jan; 28(1):1-10. PMID: 24219608; PMCID: PMC3925365.
      55. Desikan RS, Thompson W, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. Heart fatty acid binding protein and Aß-associated Alzheimer's neurodegeneration. Mol Neurodegener. 2013 Oct 02; 8:39. PMID: 24088526; PMCID: PMC3850652.
      56. Kremen WS, Fennema-Notestine C, Eyler LT, Panizzon MS, Chen CH, Franz CE, Lyons MJ, Thompson W, Dale AM. Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):751-61. PMID: 24132907; PMCID: PMC4754776.
      57. Chen CH, Fiecas M, Gutiérrez ED, Panizzon MS, Eyler LT, Vuoksimaa E, Thompson W, Fennema-Notestine C, Hagler DJ, Jernigan TL, Neale MC, Franz CE, Lyons MJ, Fischl B, Tsuang MT, Dale AM, Kremen WS. Genetic topography of brain morphology. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17089-94. PMID: 24082094; PMCID: PMC3801007.
      58. Vahia IV, Camacho A, Depp CA, Herrera A, Thompson W, Munoz R, Jeste DV, Ng B. To what factors do rural-dwelling hispanics attribute depressive symptoms? Depress Res Treat. 2013; 2013:781986. PMID: 23781333; PMCID: PMC3677663.
      59. Moore RC, Moore DJ, Thompson W, Vahia IV, Grant I, Jeste DV. A case-controlled study of successful aging in older HIV-infected adults. J Clin Psychiatry. 2013 May; 74(5):e417-23. PMID: 23759460; PMCID: PMC3683870.
      60. Thomas ML, Brown GG, Thompson W, Voyvodic J, Greve DN, Turner JA, Mathalon DH, Ford J, Wible CG, Potkin SG. An application of item response theory to fMRI data: prospects and pitfalls. Psychiatry Res. 2013 Jun 30; 212(3):167-74. PMID: 23642468; PMCID: PMC3775707.
      61. Schork AJ, Thompson W, Pham P, Torkamani A, Roddey JC, Sullivan PF, Kelsoe JR, O'Donovan MC, Furberg H, Schork NJ, Andreassen OA, Dale AM. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet. 2013 Apr; 9(4):e1003449. PMID: 23637621; PMCID: PMC3636284.
      62. Andreassen OA, Thompson W, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P, Roddey JC, Chen CH, McEvoy L, Desikan RS, Djurovic S, Dale AM. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet. 2013 Apr; 9(4):e1003455. PMID: 23637625; PMCID: PMC3636100.
      63. Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S, Winkelmann J, Mitrovic M, Braun F, Ponsioen CY, Croucher PJ, Sterneck M, Teufel A, Mason AL, Saarela J, Leppa V, Dorfman R, Alvaro D, Floreani A, Onengut-Gumuscu S, Rich SS, Thompson W, Schork AJ, Næss S, Thomsen I, Mayr G, König IR, Hveem K, Cleynen I, Gutierrez-Achury J, Ricaño-Ponce I, van Heel D, Björnsson E, Sandford RN, Durie PR, Melum E, Vatn MH, Silverberg MS, Duerr RH, Padyukov L, Brand S, Sans M, Annese V, Achkar JP, Boberg KM, Marschall HU, Chazouillères O, Bowlus CL, Wijmenga C, Schrumpf E, Vermeire S, Albrecht M, Rioux JD, Alexander G, Bergquist A, Cho J, Schreiber S, Manns MP, Färkkilä M, Dale AM, Chapman RW, Lazaridis KN, Franke A, Anderson CA, Karlsen TH. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet. 2013 Jun; 45(6):670-5. PMID: 23603763; PMCID: PMC3667736.
      64. Vuoksimaa E, Panizzon MS, Chen CH, Eyler LT, Fennema-Notestine C, Fiecas MJ, Fischl B, Franz CE, Grant MD, Jak AJ, Lyons MJ, Neale MC, Thompson W, Tsuang MT, Xian H, Dale AM, Kremen WS. Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age. Neuropsychologia. 2013 May; 51(6):1124-31. PMID: 23499725; PMCID: PMC3660613.
      65. Jeste DV, Savla GN, Thompson W, Vahia IV, Glorioso DK, Martin AS, Palmer BW, Rock D, Golshan S, Kraemer HC, Depp CA. Association between older age and more successful aging: critical role of resilience and depression. Am J Psychiatry. 2013 Feb; 170(2):188-96. PMID: 23223917; PMCID: PMC3593664.
      66. Andreassen OA, Djurovic S, Thompson W, Schork AJ, Kendler KS, O'Donovan MC, Rujescu D, Werge T, van de Bunt M, Morris AP, McCarthy MI, Roddey JC, McEvoy LK, Desikan RS, Dale AM. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013 Feb 07; 92(2):197-209. PMID: 23375658; PMCID: PMC3567279.
      67. Chou HH, Talledo JA, Lamb SN, Thompson W, Swerdlow NR. Amphetamine effects on MATRICS Consensus Cognitive Battery performance in healthy adults. Psychopharmacology (Berl). 2013 May; 227(1):165-76. PMID: 23314393; PMCID: PMC3624060.
      68. Max JE, Pardo D, Hanten G, Schachar RJ, Saunders AE, Ewing-Cobbs L, Chapman SB, Dennis M, Wilde EA, Bigler ED, Thompson W, Yang TT, Levin HS. Psychiatric disorders in children and adolescents six-to-twelve months after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2013; 25(4):272-82. PMID: 24247854; PMCID: PMC5009904.
      69. Thompson W, Savla GN, Vahia IV, Depp CA, O'Hara R, Jeste DV, Palmer BW. Characterizing trajectories of cognitive functioning in older adults with schizophrenia: does method matter? Schizophr Res. 2013 Jan; 143(1):90-6. PMID: 23218560; PMCID: PMC3540183.
      70. Max JE, Wilde EA, Bigler ED, Thompson W, MacLeod M, Vasquez AC, Merkley TL, Hunter JV, Chu ZD, Yallampalli R, Hotz G, Chapman SB, Yang TT, Levin HS. Neuroimaging correlates of novel psychiatric disorders after pediatric traumatic brain injury. J Am Acad Child Adolesc Psychiatry. 2012 Nov; 51(11):1208-17. PMID: 23101746; PMCID: PMC3511860.
      71. Siegle GJ, Thompson W, Collier A, Berman SR, Feldmiller J, Thase ME, Friedman ES. Toward clinically useful neuroimaging in depression treatment: prognostic utility of subgenual cingulate activity for determining depression outcome in cognitive therapy across studies, scanners, and patient characteristics. Arch Gen Psychiatry. 2012 Sep; 69(9):913-24. PMID: 22945620; PMCID: PMC3951953.
      72. Gershon A, Thompson W, Eidelman P, McGlinchey EL, Kaplan KA, Harvey AG. Restless pillow, ruffled mind: sleep and affect coupling in interepisode bipolar disorder. J Abnorm Psychol. 2012 Nov; 121(4):863-73. PMID: 22845651; PMCID: PMC3612504.
      73. Desikan RS, McEvoy LK, Thompson W, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM. Amyloid-ß--associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol. 2012 Jun; 69(6):709-13. PMID: 22529247; PMCID: PMC3423526.
      74. O'Hara R, Marcus P, Thompson W, Flournoy J, Vahia I, Lin X, Hallmayer J, Depp C, Jeste DV. 5-HTTLPR short allele, resilience, and successful aging in older adults. Am J Geriatr Psychiatry. 2012 May; 20(5):452-6. PMID: 22233775; PMCID: PMC3326186.
      75. Wetherill RR, Bava S, Thompson W, Boucquey V, Pulido C, Yang TT, Tapert SF. Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism. Brain Res. 2012 Jan 13; 1432:66-73. PMID: 22138427; PMCID: PMC3246051.
      76. Vahia IV, Thompson W, Depp CA, Allison M, Jeste DV. Developing a dimensional model for successful cognitive and emotional aging. Int Psychogeriatr. 2012 Apr; 24(4):515-23. PMID: 22050770.
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      77. Desikan RS, McEvoy LK, Thompson W, Holland D, Roddey JC, Blennow K, Aisen PS, Brewer JB, Hyman BT, Dale AM. Amyloid-ß associated volume loss occurs only in the presence of phospho-tau. Ann Neurol. 2011 Oct; 70(4):657-61. PMID: 22002658; PMCID: PMC3368003.
      78. Herrera AP, Smith ML, Ory MG, Rodriguez HP, Warre R, Thompson W, Azcue A, Romero JA. The provision of diabetes-monitoring exams to older Latinos. J Aging Health. 2011 Oct; 23(7):1075-100. PMID: 21948771; PMCID: PMC3378317.
      79. Ichikawa N, Siegle GJ, Jones NP, Kamishima K, Thompson W, Gross JJ, Ohira H. Feeling bad about screwing up: emotion regulation and action monitoring in the anterior cingulate cortex. Cogn Affect Behav Neurosci. 2011 Sep; 11(3):354-71. PMID: 21590316; PMCID: PMC4128506.
      80. Thompson W, Charo L, Vahia IV, Depp C, Allison M, Jeste DV. Association between higher levels of sexual function, activity, and satisfaction and self-rated successful aging in older postmenopausal women. J Am Geriatr Soc. 2011 Aug; 59(8):1503-8. PMID: 21797827; PMCID: PMC4151627.
      81. Thompson W, Hallmayer J, O'Hara R. Design considerations for characterizing psychiatric trajectories across the lifespan: application to effects of APOE-e4 on cerebral cortical thickness in Alzheimer's disease. Am J Psychiatry. 2011 Sep; 168(9):894-903. PMID: 21724665.
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      82. Herrera AP, Meeks TW, Dawes SE, Hernandez DM, Thompson W, Sommerfeld DH, Allison MA, Jeste DV. Emotional and cognitive health correlates of leisure activities in older Latino and Caucasian women. Psychol Health Med. 2011 Dec; 16(6):661-74. PMID: 21391135; PMCID: PMC3134532.
      83. Majid DS, Stoffers D, Sheldon S, Hamza S, Thompson W, Goldstein J, Corey-Bloom J, Aron AR. Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 year. Mov Disord. 2011 Jul; 26(8):1481-8. PMID: 21484871; PMCID: PMC3136652.
      84. Eyler LT, Prom-Wormley E, Panizzon MS, Kaup AR, Fennema-Notestine C, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Stevens A, Pacheco J, Perry ME, Schmitt JE, Seidman LJ, Thermenos HW, Tsuang MT, Chen CH, Thompson W, Jak A, Dale AM, Kremen WS. Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study. Cereb Cortex. 2011 Oct; 21(10):2313-21. PMID: 21378112; PMCID: PMC3169660.
      85. Kavirajan H, Vahia IV, Thompson W, Depp C, Allison M, Jeste DV. Attitude Toward Own Aging and Mental Health in Post-menopausal Women. Asian J Psychiatr. 2011 Mar 01; 4(1):26-30. PMID: 21607197.
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      86. Thompson W, Holland D. Bias in tensor based morphometry Stat-ROI measures may result in unrealistic power estimates. Neuroimage. 2011 Jul 01; 57(1):1-4. PMID: 21349340; PMCID: PMC3471806.
      87. Silk JS, Forbes EE, Whalen DJ, Jakubcak JL, Thompson W, Ryan ND, Axelson DA, Birmaher B, Dahl RE. Daily emotional dynamics in depressed youth: a cell phone ecological momentary assessment study. J Exp Child Psychol. 2011 Oct; 110(2):241-57. PMID: 21112595; PMCID: PMC3061240.
      88. Savla GN, Twamley EW, Thompson W, Delis DC, Jeste DV, Palmer BW. Evaluation of specific executive functioning skills and the processes underlying executive control in schizophrenia. J Int Neuropsychol Soc. 2011 Jan; 17(1):14-23. PMID: 21062522; PMCID: PMC3616491.
      89. Brown GG, Mathalon DH, Stern H, Ford J, Mueller B, Greve DN, McCarthy G, Voyvodic J, Glover G, Diaz M, Yetter E, Ozyurt IB, Jorgensen KW, Wible CG, Turner JA, Thompson W, Potkin SG. Multisite reliability of cognitive BOLD data. Neuroimage. 2011 Feb 01; 54(3):2163-75. PMID: 20932915; PMCID: PMC3009557.
      90. Depp CA, Schkade DA, Thompson W, Jeste DV. Age, affective experience, and television use. Am J Prev Med. 2010 Aug; 39(2):173-8. PMID: 20621265; PMCID: PMC3593658.
      91. Versace A, Almeida JR, Quevedo K, Thompson W, Terwilliger RA, Hassel S, Kupfer DJ, Phillips ML. Right orbitofrontal corticolimbic and left corticocortical white matter connectivity differentiate bipolar and unipolar depression. Biol Psychiatry. 2010 Sep 15; 68(6):560-7. PMID: 20598288; PMCID: PMC3743239.
      92. Versace A, Thompson W, Zhou D, Almeida JR, Hassel S, Klein CR, Kupfer DJ, Phillips ML. Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry. 2010 Mar 01; 67(5):422-31. PMID: 20159144; PMCID: PMC2835157.
      93. Vahia IV, Meeks TW, Thompson W, Depp CA, Zisook S, Allison M, Judd LL, Jeste DV. Subthreshold depression and successful aging in older women. Am J Geriatr Psychiatry. 2010 Mar; 18(3):212-20. PMID: 20224518; PMCID: PMC3937985.
      94. Brown GG, Thompson W. Functional brain imaging in schizophrenia: selected results and methods. Curr Top Behav Neurosci. 2010; 4:181-214. PMID: 21312401.
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      95. Zhou D, Thompson W, Siegle G. MATLAB toolbox for functional connectivity. Neuroimage. 2009 Oct 01; 47(4):1590-607. PMID: 19520177; PMCID: PMC2728136.
      96. Fagiolini A, Frank E, Axelson DA, Birmaher B, Cheng Y, Curet DE, Friedman ES, Gildengers AG, Goldstein T, Grochocinski VJ, Houck PR, Stofko MG, Thase ME, Thompson W, Turkin SR, Kupfer DJ. Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study. Bipolar Disord. 2009 Jun; 11(4):382-90. PMID: 19500091; PMCID: PMC3361715.
      97. Rosen O, Thompson W. A Bayesian regression model for multivariate functional data. Comput Stat Data Anal. 2009 Sep 01; 53(11):3773-3786. PMID: 28936016.
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      98. Thompson W, Siegle G. A stimulus-locked vector autoregressive model for slow event-related fMRI designs. Neuroimage. 2009 Jul 01; 46(3):739-48. PMID: 19236927; PMCID: PMC2674141.
      99. Lenze SN, Cyranowski JM, Thompson W, Anderson B, Frank E. The cumulative impact of nonsevere life events predicts depression recurrence during maintenance treatment with interpersonal psychotherapy. J Consult Clin Psychol. 2008 Dec; 76(6):979-87. PMID: 19045966; PMCID: PMC2597551.
      100. Soreca I, Fagiolini A, Frank E, Houck PR, Thompson W, Kupfer DJ. Relationship of general medical burden, duration of illness and age in patients with bipolar I disorder. J Psychiatr Res. 2008 Sep; 42(11):956-61. PMID: 18076906.
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      101. Monk TH, Begley AE, Billy BD, Fletcher ME, Germain A, Mazumdar S, Moul DE, Shear MK, Thompson W, Zarotney JR. Sleep and circadian rhythms in spousally bereaved seniors. Chronobiol Int. 2008 Feb; 25(1):83-98. PMID: 18293151; PMCID: PMC2806655.
      102. Frank E, Cassano GB, Rucci P, Fagiolini A, Maggi L, Kraemer HC, Kupfer DJ, Pollock B, Bies R, Nimgaonkar V, Pilkonis P, Shear MK, Thompson W, Grochocinski VJ, Scocco P, Buttenfield J, Forgione RN. Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depression. Clin Trials. 2008; 5(3):253-61. PMID: 18559415; PMCID: PMC3387666.
      103. Thompson W, Rosen O. A Bayesian model for sparse functional data. Biometrics. 2008 Mar; 64(1):54-63. PMID: 17573864.
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      104. Monk TH, Thompson W, Buysse DJ, Hall M, Nofzinger EA, Reynolds CF. Sleep in healthy seniors: a diary study of the relation between bedtime and the amount of sleep obtained. J Sleep Res. 2006 Sep; 15(3):256-60. PMID: 16911027.
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      105. Thompson W, Kupfer DJ, Fagiolini A, Scott JA, Frank E. Prevalence and clinical correlates of medical comorbidities in patients with bipolar I disorder: analysis of acute-phase data from a randomized controlled trial. J Clin Psychiatry. 2006 May; 67(5):783-8. PMID: 16841628.
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      106. Monk TH, Buysse DJ, Hall M, Nofzinger EA, Thompson W, Mazumdar SA, Reynolds CF. Age-related differences in the lifestyle regularity of seniors experiencing bereavement, care-giving, insomnia, and advancement into old-old age. Chronobiol Int. 2006; 23(4):831-41. PMID: 16887751.
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      107. Thompson W, Xie M, White HR. Transformations of covariates for longitudinal data. Biostatistics. 2003 Jul; 4(3):353-64. PMID: 12925503.
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