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David Karow

TitleAssociate Clinical Professor
InstitutionUniversity of California San Diego
DepartmentRadiology
Address9500 Gilman Drive #0841
La Jolla CA 92093
Phone858-534-8447
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los AngelesFellowship2012Abdominal Imaging
    University of California, San DiegoResidency2011Diagnostic Radiology
    University of California, IrvineInternship2006Internal Medicine
    University of MichiganM.D./Ph.D.2005Medicine
    University of MichiganB.S1994Cellular and Molecular Biology
    Collapse Awards and Honors
    University of California, San Diego Department of Radiology2014Excellence in Clinical Innovation Award
    University of California, San Diego Department of Radiology Alumni Association2011Elliott C. Lasser Award for Excellence in Research
    Radiology2010Original research selected as the cover for the September 2010 issue
    American Roentgen Ray Society2009Executive Council Award
    Radiology Society of North America2008RSNA Trainee Research Prize
    University of California, Irvine, Department of Internal Medicine2005Letter of Commendation
    University of Michigan Medical School2005Recipient of the Dean’s Award for Research Excellence
    University of Michigan Medical School, Medical Scientist Training Program2005Recipient of the MSTP (M.D./Ph.D.) Excellence in Research Award
    University of Michigan Medical School2005Selected to graduate with Distinction in Research
    Nominated by Dr. Jonathan Gleadle, Ph.D., of the Wellcome Trust Centre for Human Genetics2004Gray, Karow et al. Nature publication was selected by Faculty 1000 as an important recent pub.
    National Institutes of Health1997  - 2005MSTP Training Grant NIGMS T32 GM07863
    University of Michigan1994Order of Omega Scholarship, Leadership and Service Award Recipient
    Kilmer Scholarship1990  - 1994Undergraduate students pursuing medical careers scholarship recipient

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc Natl Acad Sci U S A. 2018 Apr 03; 115(14):3686-3691. PMID: 29555771.
      View in: PubMed
    2. Seibert TM, Fan CC, Wang Y, Zuber V, Karunamuni R, Parsons JK, Eeles RA, Easton DF, Kote-Jarai Z, Al Olama AA, Garcia SB, Muir K, Grönberg H, Wiklund F, Aly M, Schleutker J, Sipeky C, Tammela TL, Nordestgaard BG, Nielsen SF, Weischer M, Bisbjerg R, Røder MA, Iversen P, Key TJ, Travis RC, Neal DE, Donovan JL, Hamdy FC, Pharoah P, Pashayan N, Khaw KT, Maier C, Vogel W, Luedeke M, Herkommer K, Kibel AS, Cybulski C, Wokolorczyk D, Kluzniak W, Cannon-Albright L, Brenner H, Cuk K, Saum KU, Park JY, Sellers TA, Slavov C, Kaneva R, Mitev V, Batra J, Clements JA, Spurdle A, Teixeira MR, Paulo P, Maia S, Pandha H, Michael A, Kierzek A, Karow DS, Mills IG, Andreassen OA, Dale AM. Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. BMJ. 2018 01 10; 360:j5757. PMID: 29321194.
      View in: PubMed
    3. Karunamuni RA, Kuperman J, Seibert TM, Schenker N, Rakow-Penner R, Sundar VS, Teruel JR, Goa PE, Karow DS, Dale AM, White NS. Relationship between kurtosis and bi-exponential characterization of high b-value diffusion-weighted imaging: application to prostate cancer. Acta Radiol. 2018 Jan 01; 284185118770889. PMID: 29665707.
      View in: PubMed
    4. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258. PMID: 28323831.
      View in: PubMed
    5. Brunsing RL, Schenker-Ahmed NM, White NS, Parsons JK, Kane C, Kuperman J, Bartsch H, Kader AK, Rakow-Penner R, Seibert TM, Margolis D, Raman SS, McDonald CR, Farid N, Kesari S, Hansel D, Shabaik A, Dale AM, Karow DS. Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI. J Magn Reson Imaging. 2017 Feb; 45(2):323-336. PMID: 27527500.
      View in: PubMed
    6. Yamin G, Schenker-Ahmed NM, Shabaik A, Adams D, Bartsch H, Kuperman J, White NS, Rakow-Penner RA, McCammack K, Parsons JK, Kane CJ, Dale AM, Karow DS. Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index with Gleason Grade in Prostate Cancer. Clin Cancer Res. 2016 Jun 01; 22(11):2668-74. PMID: 27250935; PMCID: PMC4896066 [Available on 06/01/17].
    7. McCammack KC, Schenker-Ahmed NM, White NS, Best SR, Marks RM, Heimbigner J, Kane CJ, Parsons JK, Kuperman JM, Bartsch H, Desikan RS, Rakow-Penner RA, Liss MA, Margolis DJ, Raman SS, Shabaik A, Dale AM, Karow DS. Restriction spectrum imaging improves MRI-based prostate cancer detection. Abdom Radiol (NY). 2016 05; 41(5):946-53. PMID: 26910114.
      View in: PubMed
    8. Liss MA, DeConde R, Caovan D, Hofler J, Gabe M, Palazzi KL, Patel ND, Lee HJ, Ideker T, Van Poppel H, Karow D, Aertsen M, Casola G, Derweesh IH. Parenchymal Volumetric Assessment as a Predictive Tool to Determine Renal Function Benefit of Nephron-Sparing Surgery Compared with Radical Nephrectomy. J Endourol. 2016 Jan; 30(1):114-21. PMID: 26192380; PMCID: PMC4841003 [Available on 01/01/17].
    9. Rakow-Penner RA, White NS, Margolis DJA, Parsons JK, Schenker-Ahmed N, Kuperman JM, Bartsch H, Choi HW, Bradley WG, Shabaik A, Huang J, Liss MA, Marks L, Kane CJ, Reiter RE, Raman SS, Karow DS, Dale AM. Prostate diffusion imaging with distortion correction. Magn Reson Imaging. 2015 Nov; 33(9):1178-1181. PMID: 26220859; PMCID: PMC4594204 [Available on 11/01/16].
    10. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. PMID: 25862742.
      View in: PubMed
    11. Liss MA, White NS, Parsons JK, Schenker-Ahmed NM, Rakow-Penner R, Kuperman JM, Bartsch H, Choi HW, Mattrey RF, Bradley WG, Shabaik A, Huang J, Margolis DJ, Raman SS, Marks LS, Kane CJ, Reiter RE, Dale AM, Karow DS. MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens. Front Oncol. 2015; 5:30. PMID: 25741473; PMCID: PMC4330697.
    12. White NS, McDonald C, McDonald CR, Farid N, Kuperman J, Karow D, Schenker-Ahmed NM, Bartsch H, Rakow-Penner R, Holland D, Shabaik A, Bjørnerud A, Hope T, Hattangadi-Gluth J, Liss M, Parsons JK, Chen CC, Raman S, Margolis D, Reiter RE, Marks L, Kesari S, Mundt AJ, Kane CJ, Kaine CJ, Carter BS, Bradley WG, Dale AM. Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging. Cancer Res. 2014 Sep 01; 74(17):4638-52. PMID: 25183788; PMCID: PMC4155409.
    13. Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Brewer JB, Hoh CK, Dale AM. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010 Sep; 256(3):932-42. PMID: 20720076; PMCID: PMC2923729.
    14. Fennema-Notestine C, Hagler DJ, McEvoy LK, Fleisher AS, Wu EH, Karow DS, Dale AM. Structural MRI biomarkers for preclinical and mild Alzheimer's disease. Hum Brain Mapp. 2009 Oct; 30(10):3238-53. PMID: 19277975; PMCID: PMC2951116.
    15. Zimmer M, Gray JM, Pokala N, Chang AJ, Karow DS, Marletta MA, Hudson ML, Morton DB, Chronis N, Bargmann CI. Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron. 2009 Mar 26; 61(6):865-79. PMID: 19323996; PMCID: PMC2760494.
    16. McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ, Holland D, Karow DS, Pung CJ, Brewer JB, Dale AM. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology. 2009 Apr; 251(1):195-205. PMID: 19201945; PMCID: PMC2663582.
    17. Chang AJ, Chronis N, Karow DS, Marletta MA, Bargmann CI. A distributed chemosensory circuit for oxygen preference in C. elegans. PLoS Biol. 2006 Sep; 4(9):e274. PMID: 16903785; PMCID: PMC1540710.
    18. Boon EM, Davis JH, Tran R, Karow DS, Huang SH, Pan D, Miazgowicz MM, Mathies RA, Marletta MA. Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain. J Biol Chem. 2006 Aug 04; 281(31):21892-902. PMID: 16728401.
      View in: PubMed
    19. Karow DS, Pan D, Davis JH, Behrends S, Mathies RA, Marletta MA. Characterization of functional heme domains from soluble guanylate cyclase. Biochemistry. 2005 Dec 13; 44(49):16266-74. PMID: 16331987; PMCID: PMC2572136.
    20. Pellicena P, Karow DS, Boon EM, Marletta MA, Kuriyan J. Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12854-9. PMID: 15326296; PMCID: PMC516465.
    21. Karow DS, Pan D, Tran R, Pellicena P, Presley A, Mathies RA, Marletta MA. Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis. Biochemistry. 2004 Aug 10; 43(31):10203-11. PMID: 15287748.
      View in: PubMed
    22. Gray JM, Karow DS, Lu H, Chang AJ, Chang JS, Ellis RE, Marletta MA, Bargmann CI. Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature. 2004 Jul 15; 430(6997):317-22. PMID: 15220933.
      View in: PubMed