David Karow

Title(s)Associate Physician Diplomate, Radiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los AngelesFellowship2012Abdominal Imaging
    University of California, San DiegoResidency2011Diagnostic Radiology
    University of California, IrvineInternship2006Internal Medicine
    University of MichiganM.D./Ph.D.2005Medicine
    University of MichiganB.S1994Cellular and Molecular Biology
    Collapse Awards and Honors
    University of California, San Diego Department of Radiology2014Excellence in Clinical Innovation Award
    University of California, San Diego Department of Radiology Alumni Association2011Elliott C. Lasser Award for Excellence in Research
    Radiology2010Original research selected as the cover for the September 2010 issue
    American Roentgen Ray Society2009Executive Council Award
    Radiology Society of North America2008RSNA Trainee Research Prize
    University of California, Irvine, Department of Internal Medicine2005Letter of Commendation
    University of Michigan Medical School2005Recipient of the Dean’s Award for Research Excellence
    University of Michigan Medical School, Medical Scientist Training Program2005Recipient of the MSTP (M.D./Ph.D.) Excellence in Research Award
    University of Michigan Medical School2005Selected to graduate with Distinction in Research
    Nominated by Dr. Jonathan Gleadle, Ph.D., of the Wellcome Trust Centre for Human Genetics2004Gray, Karow et al. Nature publication was selected by Faculty 1000 as an important recent pub.
    National Institutes of Health1997  - 2005MSTP Training Grant NIGMS T32 GM07863
    University of Michigan1994Order of Omega Scholarship, Leadership and Service Award Recipient
    Kilmer Scholarship1990  - 1994Undergraduate students pursuing medical careers scholarship recipient

    Collapse Overview 

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Multicompartmental Diffusion Model for Improved Assessment of Whole-Body Diffusion-weighted Imaging Data and Evaluation of Prostate Cancer Bone Metastases. Radiol Imaging Cancer. 2023 01; 5(1):e210115. Conlin CC, Feng CH, Digma LA, Rodríguez-Soto AE, Kuperman JM, Rakow-Penner R, Karow DS, White NS, Seibert TM, Hahn ME, Dale AM. PMID: 36705559; PMCID: PMC9896230.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Oncologically Relevant Findings Reporting and Data System (ONCO-RADS): Guidelines for the Acquisition, Interpretation, and Reporting of Whole-Body MRI for Cancer Screening. Radiology. 2021 06; 299(3):494-507. Petralia G, Koh DM, Attariwala R, Busch JJ, Eeles R, Karow D, Lo GG, Messiou C, Sala E, Vargas HA, Zugni F, Padhani AR. PMID: 33904776.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    3. Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):3053-3062. Hou YC, Yu HC, Martin R, Cirulli ET, Schenker-Ahmed NM, Hicks M, Cohen IV, Jönsson TJ, Heister R, Napier L, Swisher CL, Dominguez S, Tang H, Li W, Perkins BA, Barea J, Rybak C, Smith E, Duchicela K, Doney M, Brar P, Hernandez N, Kirkness EF, Kahn AM, Venter JC, Karow DS, Caskey CT. PMID: 31980526; PMCID: PMC7022190.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    4. An unsupervised learning approach to identify novel signatures of health and disease from multimodal data. Genome Med. 2020 01 10; 12(1):7. Shomorony I, Cirulli ET, Huang L, Napier LA, Heister RR, Hicks M, Cohen IV, Yu HC, Swisher CL, Schenker-Ahmed NM, Li W, Nelson KE, Brar P, Kahn AM, Spector TD, Caskey CT, Venter JC, Karow DS, Kirkness EF, Shah N. PMID: 31924279; PMCID: PMC6953286.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    5. Utility of Restriction Spectrum Imaging Among Men Undergoing First-Time Biopsy for Suspected Prostate Cancer. AJR Am J Roentgenol. 2019 08; 213(2):365-370. Felker ER, Raman SS, Shakeri S, Mirak SA, Bajgiran AM, Kwan L, Khoshnoodi P, ElKhoury FF, Margolis DJA, Karow D, Lu DSK, White N, Marks LS. PMID: 31039011; PMCID: PMC6666387.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    6. Relationship between kurtosis and bi-exponential characterization of high b-value diffusion-weighted imaging: application to prostate cancer. Acta Radiol. 2018 Dec; 59(12):1523-1529. Karunamuni RA, Kuperman J, Seibert TM, Schenker N, Rakow-Penner R, Sundar VS, Teruel JR, Goa PE, Karow DS, Dale AM, White NS. PMID: 29665707.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc Natl Acad Sci U S A. 2018 04 03; 115(14):3686-3691. Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC. PMID: 29555771; PMCID: PMC5889622.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    8. Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. BMJ. 2018 01 10; 360:j5757. Seibert TM, Fan CC, Wang Y, Zuber V, Karunamuni R, Parsons JK, Eeles RA, Easton DF, Kote-Jarai Z, Al Olama AA, Garcia SB, Muir K, Grönberg H, Wiklund F, Aly M, Schleutker J, Sipeky C, Tammela TL, Nordestgaard BG, Nielsen SF, Weischer M, Bisbjerg R, Røder MA, Iversen P, Key TJ, Travis RC, Neal DE, Donovan JL, Hamdy FC, Pharoah P, Pashayan N, Khaw KT, Maier C, Vogel W, Luedeke M, Herkommer K, Kibel AS, Cybulski C, Wokolorczyk D, Kluzniak W, Cannon-Albright L, Brenner H, Cuk K, Saum KU, Park JY, Sellers TA, Slavov C, Kaneva R, Mitev V, Batra J, Clements JA, Spurdle A, Teixeira MR, Paulo P, Maia S, Pandha H, Michael A, Kierzek A, Karow DS, Mills IG, Andreassen OA, Dale AM, PRACTICAL Consortium*. PMID: 29321194; PMCID: PMC5759091.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    9. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 03; 14(3):e1002258. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. PMID: 28323831; PMCID: PMC5360219.
      View in: PubMed   Mentions: 195     Fields:    Translation:Humans
    10. Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI. J Magn Reson Imaging. 2017 02; 45(2):323-336. Brunsing RL, Schenker-Ahmed NM, White NS, Parsons JK, Kane C, Kuperman J, Bartsch H, Kader AK, Rakow-Penner R, Seibert TM, Margolis D, Raman SS, McDonald CR, Farid N, Kesari S, Hansel D, Shabaik A, Dale AM, Karow DS. PMID: 27527500; PMCID: PMC5222783.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    11. Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index with Gleason Grade in Prostate Cancer. Clin Cancer Res. 2016 06 01; 22(11):2668-74. Yamin G, Schenker-Ahmed NM, Shabaik A, Adams D, Bartsch H, Kuperman J, White NS, Rakow-Penner RA, McCammack K, Parsons JK, Kane CJ, Dale AM, Karow DS. PMID: 27250935; PMCID: PMC4896066.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    12. Restriction spectrum imaging improves MRI-based prostate cancer detection. Abdom Radiol (NY). 2016 05; 41(5):946-53. McCammack KC, Schenker-Ahmed NM, White NS, Best SR, Marks RM, Heimbigner J, Kane CJ, Parsons JK, Kuperman JM, Bartsch H, Desikan RS, Rakow-Penner RA, Liss MA, Margolis DJ, Raman SS, Shabaik A, Dale AM, Karow DS. PMID: 26910114; PMCID: PMC5386962.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    13. In vivo prostate cancer detection and grading using restriction spectrum imaging-MRI. Prostate Cancer Prostatic Dis. 2016 06; 19(2):168-73. McCammack KC, Kane CJ, Parsons JK, White NS, Schenker-Ahmed NM, Kuperman JM, Bartsch H, Desikan RS, Rakow-Penner RA, Adams D, Liss MA, Mattrey RF, Bradley WG, Margolis DJ, Raman SS, Shabaik A, Dale AM, Karow DS. PMID: 26754261; PMCID: PMC5340721.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    14. Parenchymal Volumetric Assessment as a Predictive Tool to Determine Renal Function Benefit of Nephron-Sparing Surgery Compared with Radical Nephrectomy. J Endourol. 2016 Jan; 30(1):114-21. Liss MA, DeConde R, Caovan D, Hofler J, Gabe M, Palazzi KL, Patel ND, Lee HJ, Ideker T, Van Poppel H, Karow D, Aertsen M, Casola G, Derweesh IH. PMID: 26192380; PMCID: PMC4841003.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    15. Prostate diffusion imaging with distortion correction. Magn Reson Imaging. 2015 Nov; 33(9):1178-1181. Rakow-Penner RA, White NS, Margolis DJA, Parsons JK, Schenker-Ahmed N, Kuperman JM, Bartsch H, Choi HW, Bradley WG, Shabaik A, Huang J, Liss MA, Marks L, Kane CJ, Reiter RE, Raman SS, Karow DS, Dale AM. PMID: 26220859; PMCID: PMC4594204.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    16. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM, Inflammation working group, IGAP and DemGene Investigators. PMID: 25862742; PMCID: PMC4677995.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    17. MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens. Front Oncol. 2015; 5:30. Liss MA, White NS, Parsons JK, Schenker-Ahmed NM, Rakow-Penner R, Kuperman JM, Bartsch H, Choi HW, Mattrey RF, Bradley WG, Shabaik A, Huang J, Margolis DJ, Raman SS, Marks LS, Kane CJ, Reiter RE, Dale AM, Karow DS. PMID: 25741473; PMCID: PMC4330697.
      View in: PubMed   Mentions: 13  
    18. Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension. Prostate Cancer Prostatic Dis. 2015 Mar; 18(1):81-5. Rakow-Penner RA, White NS, Parsons JK, Choi HW, Liss MA, Kuperman JM, Schenker-Ahmed N, Bartsch H, Mattrey RF, Bradley WG, Shabaik A, Huang J, Margolis DJ, Raman SS, Marks L, Kane CJ, Reiter RE, Karow DS, Dale AM. PMID: 25559097.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging. Cancer Res. 2014 Sep 01; 74(17):4638-52. White NS, McDonald C, McDonald CR, Farid N, Kuperman J, Karow D, Schenker-Ahmed NM, Bartsch H, Rakow-Penner R, Holland D, Shabaik A, Bjørnerud A, Hope T, Hattangadi-Gluth J, Liss M, Parsons JK, Chen CC, Raman S, Margolis D, Reiter RE, Marks L, Kesari S, Mundt AJ, Kane CJ, Kaine CJ, Carter BS, Bradley WG, Dale AM. PMID: 25183788; PMCID: PMC4155409.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    20. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010 Sep; 256(3):932-42. Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Brewer JB, Hoh CK, Dale AM, Alzheimer's Disease Neuroimaging Initiative. PMID: 20720076; PMCID: PMC2923729.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    21. Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 2010 Feb; 31(2):347-54. Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Karow D, Dale AM, Alzheimer's Disease Neuroimaging Initiative. PMID: 20075088; PMCID: PMC2821467.
      View in: PubMed   Mentions: 137     Fields:    Translation:Humans
    22. Structural MRI biomarkers for preclinical and mild Alzheimer's disease. Hum Brain Mapp. 2009 Oct; 30(10):3238-53. Fennema-Notestine C, Hagler DJ, McEvoy LK, Fleisher AS, Wu EH, Karow DS, Dale AM, Alzheimer's Disease Neuroimaging Initiative. PMID: 19277975; PMCID: PMC2951116.
      View in: PubMed   Mentions: 127     Fields:    Translation:Humans
    23. Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron. 2009 Mar 26; 61(6):865-79. Zimmer M, Gray JM, Pokala N, Chang AJ, Karow DS, Marletta MA, Hudson ML, Morton DB, Chronis N, Bargmann CI. PMID: 19323996; PMCID: PMC2760494.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    24. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology. 2009 Apr; 251(1):195-205. McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ, Holland D, Karow DS, Pung CJ, Brewer JB, Dale AM, Alzheimer's Disease Neuroimaging Initiative. PMID: 19201945; PMCID: PMC2663582.
      View in: PubMed   Mentions: 158     Fields:    Translation:Humans
    25. Multi-modal imaging predicts memory performance in normal aging and cognitive decline. Neurobiol Aging. 2010 Jul; 31(7):1107-21. Walhovd KB, Fjell AM, Dale AM, McEvoy LK, Brewer J, Karow DS, Salmon DP, Fennema-Notestine C, Alzheimer's Disease Neuroimaging Initiative. PMID: 18838195; PMCID: PMC3947581.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    26. A distributed chemosensory circuit for oxygen preference in C. elegans. PLoS Biol. 2006 Sep; 4(9):e274. Chang AJ, Chronis N, Karow DS, Marletta MA, Bargmann CI. PMID: 16903785; PMCID: PMC1540710.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    27. Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain. J Biol Chem. 2006 Aug 04; 281(31):21892-21902. Boon EM, Davis JH, Tran R, Karow DS, Huang SH, Pan D, Miazgowicz MM, Mathies RA, Marletta MA. PMID: 16728401.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    28. Characterization of functional heme domains from soluble guanylate cyclase. Biochemistry. 2005 Dec 13; 44(49):16266-74. Karow DS, Pan D, Davis JH, Behrends S, Mathies RA, Marletta MA. PMID: 16331987; PMCID: PMC2572136.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    29. Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12854-9. Pellicena P, Karow DS, Boon EM, Marletta MA, Kuriyan J. PMID: 15326296; PMCID: PMC516465.
      View in: PubMed   Mentions: 112     Fields:    Translation:Cells
    30. Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis. Biochemistry. 2004 Aug 10; 43(31):10203-11. Karow DS, Pan D, Tran R, Pellicena P, Presley A, Mathies RA, Marletta MA. PMID: 15287748.
      View in: PubMed   Mentions: 77     Fields:    Translation:Cells
    31. Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature. 2004 Jul 15; 430(6997):317-22. Gray JM, Karow DS, Lu H, Chang AJ, Chang JS, Ellis RE, Marletta MA, Bargmann CI. PMID: 15220933.
      View in: PubMed   Mentions: 280     Fields:    Translation:AnimalsCells
    32. RNA polymerase II-dependent positional effects on mRNA 3' end processing in the adenovirus major late transcription unit. J Biol Chem. 2001 Nov 09; 276(45):41825-31. Ahuja D, Karow DS, Kilpatrick JE, Imperiale MJ. PMID: 11551915.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
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