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Kathleen Curtius

Title(s)Assistant Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-2678-0960 Additional info
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    Collapse Biography 
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    University of Washington, Seattle, WAPhD08/2015Applied Mathematics
    University of Washington, Seattle, WAMS06/2011Applied Mathematics
    University of California Los Angeles, Los Angeles, CABS06/2010Mathematics

    Collapse Overview 
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    In July 2020, Dr. Kathleen (Kit) Curtius joined UCSD as an Assistant Professor in the Division for Biomedical Informatics, Department of Medicine. She is also an Associate Member of the Cancer Control Program at UCSD Moores Cancer Center. She previously held a Medical Research Council Rutherford Fellowship at Barts Cancer Institute in London UK, where she began as a postdoc in Prof Trevor Graham’s Evolution and Cancer lab in 2016. Before moving to the UK, Dr. Curtius was a Gastroenterology Research Fellow in the University of Washington (UW) Department of Medicine working with Dr. John Inadomi. She received her PhD in Applied Mathematics from UW in 2015, working with advisor Dr. Georg Luebeck at the Fred Hutchinson Cancer Research Center, and obtained a BS in Mathematics from UCLA in 2010.

    The research aim of her interdisciplinary group, the Quantitative Cancer Control laboratory, is to improve the ability to detect and prevent cancer at the earliest stages. To achieve this, the team develops ways to use mathematical reasoning to better understand the correlations between multi-scale cancer data arising from the underlying process of somatic evolution. Their translational work requires integration with screening guideline committees, clinicians, geneticists, molecular and computational biologists, and other areas that are primed for novel informatics and modeling approaches in cancer control efforts.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma. Cancer Res. 2020 Nov 15; 80(22):4946-4959. Tamura N, Shaikh N, Muliaditan D, Soliman TN, McGuinness JR, Maniati E, Moralli D, Durin MA, Green CM, Balkwill FR, Wang J, Curtius K, McClelland SE. PMID: 32998996.
      View in: PubMed   Mentions:    Fields:    
    2. A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples. NAR Genom Bioinform. 2020 Mar; 2(1):lqz017. Saunderson EA, Baker AM, Williams M, Curtius K, Jones JL, Graham TA, Ficz G. PMID: 31867579.
      View in: PubMed   Mentions:
    3. The 2019 mathematical oncology roadmap. Phys Biol. 2019 06 19; 16(4):041005. Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth DA, Jarrett AM, Lima EABF, Tinsley Oden J, Biros G, Yankeelov TE, Curtius K, Al Bakir I, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley SD, Enderling H, Caudell J, Moros EG, Anderson ARA, Gatenby RA, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG. PMID: 30991381.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    4. From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology. Front Immunol. 2018; 9:2368. Al Bakir I, Curtius K, Graham TA. PMID: 30386335.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. Implications of Epigenetic Drift in Colorectal Neoplasia. Cancer Res. 2019 02 01; 79(3):495-504. Luebeck GE, Hazelton WD, Curtius K, Maden SK, Yu M, Carter KT, Burke W, Lampe PD, Li CI, Ulrich CM, Newcomb PA, Westerhoff M, Kaz AM, Luo Y, Inadomi JM, Grady WM. PMID: 30291105.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. Evolutionary history of human colitis-associated colorectal cancer. Gut. 2019 06; 68(6):985-995. Baker AM, Cross W, Curtius K, Al Bakir I, Choi CR, Davis HL, Temko D, Biswas S, Martinez P, Williams MJ, Lindsay JO, Feakins R, Vega R, Hayes SJ, Tomlinson IPM, McDonald SAC, Moorghen M, Silver A, East JE, Wright NA, Wang LM, Rodriguez-Justo M, Jansen M, Hart AL, Leedham SJ, Graham TA. PMID: 29991641.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    7. An evolutionary perspective on field cancerization. Nat Rev Cancer. 2018 Jan; 18(1):19-32. Curtius K, Wright NA, Graham TA. PMID: 29217838.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    8. Evolution of Premalignant Disease. Cold Spring Harb Perspect Med. 2017 Dec 01; 7(12). Curtius K, Wright NA, Graham TA. PMID: 28490542.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    9. Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma. Clin Epigenetics. 2017; 9:113. Luebeck EG, Curtius K, Hazelton WD, Maden S, Yu M, Thota PN, Patil DT, Chak A, Willis JE, Grady WM. PMID: 29046735.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Radiofrequency Ablation of Barrett's Esophagus Reduces Esophageal Adenocarcinoma Incidence and Mortality in a Comparative Modeling Analysis. Clin Gastroenterol Hepatol. 2017 09; 15(9):1471-1474. Kroep S, Heberle CR, Curtius K, Kong CY, Lansdorp-Vogelaar I, Ali A, Wolf WA, Shaheen NJ, Spechler SJ, Rubenstein JH, Nishioka NS, Meltzer SJ, Hazelton WD, van Ballegooijen M, Tramontano AC, Gazelle GS, Luebeck EG, Inadomi JM, Hur C. PMID: 28089850.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. PLoS Comput Biol. 2016 05; 12(5):e1004919. Curtius K, Wong CJ, Hazelton WD, Kaz AM, Chak A, Willis JE, Grady WM, Luebeck EG. PMID: 27168458.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    12. A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus. PLoS Comput Biol. 2015 May; 11(5):e1004272. Curtius K, Hazelton WD, Jeon J, Luebeck EG. PMID: 26001209.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    13. The Role of Gastroesophageal Reflux and Other Factors during Progression to Esophageal Adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2015 Jul; 24(7):1012-23. Hazelton WD, Curtius K, Inadomi JM, Vaughan TL, Meza R, Rubenstein JH, Hur C, Luebeck EG. PMID: 25931440.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    14. Exploring the recent trend in esophageal adenocarcinoma incidence and mortality using comparative simulation modeling. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):997-1006. Kong CY, Kroep S, Curtius K, Hazelton WD, Jeon J, Meza R, Heberle CR, Miller MC, Choi SE, Lansdorp-Vogelaar I, van Ballegooijen M, Feuer EJ, Inadomi JM, Hur C, Luebeck EG. PMID: 24692500.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    15. Impact of tumor progression on cancer incidence curves. Cancer Res. 2013 Feb 01; 73(3):1086-96. Luebeck EG, Curtius K, Jeon J, Hazelton WD. PMID: 23054397.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
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