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Sidney Zisook

Title(s)Professor, Psychiatry
SchoolHealth Sciences
Phone858-249-1371
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    Biography
    Sidney Zisook, M.D., is director of the University of California, San Diego Residency Training Program, and a Distinguished Professor of Psychiatry at UCSD. Dr. Zisook received his Bachelor of Arts from the University of California at Berkeley and his medical degree from Stritch-Loyola, Chicago. He completed his residency in Psychiatry at Massachusetts General Hospital in Boston and was a clinical fellow of Harvard Medical School.

    Research Interests
    Dr. Zisook’s research centers around mood as both a primary and secondary manifestation/disorder. Much of his research has been focused on the natural history, differentiation from depression and treatment of grief and bereavement. Current research projects include: 1) treatment of bereavement – associated depression; 2) interventions for traumatic (aka complicated) grief; 3) interventions for treatment resistant depression; 4) predicting antidepressant response; 5) preventing physician suicide. Dr. Zisook also is Director of the Operation Core of the Advanced Interventions Center for Older Persons with Psychotic Disorders.

    Clinical Focus
    Dr. Zisook’s major clinical focus is treatment of adult patients with grief, mood and anxiety disorders. Using an integrated approach which combines various psychotherapeutic modalities with pharmacotherapy, Dr. Zisook provides consultation for patients with particularly chronic and refractory conditions, individuals with complicated bereavement reactions, and older persons with mood and/or anxiety disorders.

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    Collapse Research Activities and Funding
    4/4-Optimizing Treatment of Complicated Grief
    NIH/NIMH R01MH085297Aug 15, 2009 - Feb 28, 2015
    Role: Principal Investigator
    Teaching Scholarly Activity in Psychiatric Training
    NIH/NIMH R13MH074298May 1, 2005 - Nov 30, 2015
    Role: Principal Investigator
    Citalopram Augmentation in Older Schizophrenia Patients
    NIH/NIMH R01MH063931Sep 1, 2001 - Aug 31, 2007
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tyree GA, Vaida F, Zisook S, Mathews WC, Grelotti DJ. Clinical correlates of depression chronicity among people living with HIV: What is the role of suicidal ideation? J Affect Disord. 2019 Nov 01; 258:163-171. PMID: 31426014.
      View in: PubMed
    2. Pospos S, Tal I, Iglewicz A, Newton IG, Tai-Seale M, Downs N, Jong P, Lee D, Davidson JE, Lee SY, Rubanovich CK, Ho EV, Sanchez C, Zisook S. Gender differences among medical students, house staff, and faculty physicians at high risk for suicide: A HEAR report. Depress Anxiety. 2019 May 17. PMID: 31102314.
      View in: PubMed
    3. Zisook S, Johnson GR, Tal I, Hicks P, Chen P, Davis L, Thase M, Zhao Y, Vertrees J, Mohamed S. General Predictors and Moderators of Depression Remission: A VAST-D Report. Am J Psychiatry. 2019 May 01; 176(5):348-357. PMID: 30947531.
      View in: PubMed
    4. Cozza SJ, Shear MK, Reynolds CF, Fisher JE, Zhou J, Maercker A, Simon N, Mauro C, Skritskaya N, Zisook S, Lebowitz B, Bloom CG, Fullerton CS, Ursano RJ. Optimizing the clinical utility of four proposed criteria for a persistent and impairing grief disorder by emphasizing core, rather than associated symptoms. Psychol Med. 2019 Mar 04; 1-8. PMID: 30829195.
      View in: PubMed
    5. Holoshitz Y, Brodsky B, Zisook S, Bernanke J, Stanley B. Application of the Zero Suicide Model in Residency Training. Acad Psychiatry. 2019 Jan 23. PMID: 30674005.
      View in: PubMed
    6. Yoon J, Zisook S, Park A, Johnson GR, Scrymgeour A, Mohamed S. Comparing Cost-Effectiveness of Aripiprazole Augmentation With Other "Next-Step" Depression Treatment Strategies: A Randomized Clinical Trial. J Clin Psychiatry. 2018 Dec 18; 80(1). PMID: 30695291.
      View in: PubMed
    7. McClure JR, Tal I, Macera CA, Ji M, Nievergelt CM, Lee SY, Kayman J, Zisook S. Agreement between self and psychiatrist reporting of suicidal ideation at a Veterans Administration psychiatric emergency clinic. Depress Anxiety. 2018 11; 35(11):1114-1121. PMID: 30102445.
      View in: PubMed
    8. Mauro C, Reynolds CF, Maercker A, Skritskaya N, Simon N, Zisook S, Lebowitz B, Cozza SJ, Shear MK. Prolonged grief disorder: clinical utility of ICD-11 diagnostic guidelines. Psychol Med. 2019 Apr; 49(5):861-867. PMID: 29909789.
      View in: PubMed
    9. Davidson JE, Stuck AR, Zisook S, Proudfoot J. Testing a Strategy to Identify Incidence of Nurse Suicide in the United States. J Nurs Adm. 2018 May; 48(5):259-265. PMID: 29672372.
      View in: PubMed
    10. Goetter EM, Mauro CM, Qiu X, Skritskaya NA, Reynolds CF, Zisook S, Shear MK, Simon NM. Treatment expectancy and working alliance in pharmacotherapy as predictors of outcomes in complicated grief. J Consult Clin Psychol. 2018 04; 86(4):367-371. PMID: 29648856.
      View in: PubMed
    11. Zisook S, Shear MK, Reynolds CF, Simon NM, Mauro C, Skritskaya NA, Lebowitz B, Wang Y, Tal I, Glorioso D, Wetherell JL, Iglewicz A, Robinaugh D, Qiu X. Treatment of Complicated Grief in Survivors of Suicide Loss: A HEAL Report. J Clin Psychiatry. 2018 Mar/Apr; 79(2). PMID: 29617064.
      View in: PubMed
    12. Davidson JE, Zisook S, Kirby B, DeMichele G, Norcross W. Suicide Prevention: A Healer Education and Referral Program for Nurses. J Nurs Adm. 2018 Feb; 48(2):85-92. PMID: 29300216.
      View in: PubMed
    13. Pospos S, Young IT, Downs N, Iglewicz A, Depp C, Chen JY, Newton I, Lee K, Light GA, Zisook S. Web-Based Tools and Mobile Applications To Mitigate Burnout, Depression, and Suicidality Among Healthcare Students and Professionals: a Systematic Review. Acad Psychiatry. 2018 Feb; 42(1):109-120. PMID: 29256033.
      View in: PubMed
    14. Robbins-Welty G, Stahl S, Zhang J, Anderson S, Schenker Y, Shear MK, Simon NM, Zisook S, Skritskaya N, Mauro C, Lebowitz BD, Reynolds CF. Medical comorbidity in complicated grief: Results from the HEAL collaborative trial. J Psychiatr Res. 2018 01; 96:94-99. PMID: 28987981.
      View in: PubMed
    15. Mohamed S, Johnson GR, Chen P, Hicks PB, Davis LL, Yoon J, Gleason TC, Vertrees JE, Weingart K, Tal I, Scrymgeour A, Lawrence DD, Planeta B, Thase ME, Huang GD, Zisook S, Rao SD, Pilkinton PD, Wilcox JA, Iranmanesh A, Sapra M, Jurjus G, Michalets JP, Aslam M, Beresford T, Anderson KD, Fernando R, Ramaswamy S, Kasckow J, Westermeyer J, Yoon G, D'Souza DC, Larson G, Anderson WG, Klatt M, Fareed A, Thompson SI, Carrera CJ, Williams SS, Juergens TM, Albers LJ, Nasdahl CS, Villarreal G, Winston JL, Nogues CA, Connolly KR, Tapp A, Jones KA, Khatkhate G, Marri S, Suppes T, LaMotte J, Hurley R, Mayeda AR, Niculescu AB, Fischer BA, Loreck DJ, Rosenlicht N, Lieske S, Finkel MS, Little JT. Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial. JAMA. 2017 Jul 11; 318(2):132-145. PMID: 28697253.
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    16. Davidson JE, Zisook S. Implementing Family-Centered Care Through Facilitated Sensemaking. AACN Adv Crit Care. 2017; 28(2):200-209. PMID: 28592480.
      View in: PubMed
    17. Tal I, Mauro C, Reynolds CF, Shear MK, Simon N, Lebowitz B, Skritskaya N, Wang Y, Qiu X, Iglewicz A, Glorioso D, Avanzino J, Wetherell JL, Karp JF, Robinaugh D, Zisook S. Complicated grief after suicide bereavement and other causes of death. Death Stud. 2017 May-Jun; 41(5):267-275. PMID: 27892842.
      View in: PubMed
    18. Mauro C, Shear MK, Reynolds CF, Simon NM, Zisook S, Skritskaya N, Wang Y, Lebowitz B, Duan N, First MB, Ghesquiere A, Gribbin C, Glickman K. Performance characteristics and clinical utility of diagnostic criteria proposals in bereaved treatment-seeking patients. Psychol Med. 2017 Mar; 47(4):608-615. PMID: 27821201.
      View in: PubMed
    19. Skritskaya NA, Mauro C, Olonoff M, Qiu X, Duncan S, Wang Y, Duan N, Lebowitz B, Reynolds CF, Simon NM, Zisook S, Shear MK. Measuring Maladaptive Cognitions in Complicated Grief: Introducing the Typical Beliefs Questionnaire. Am J Geriatr Psychiatry. 2017 May; 25(5):541-550. PMID: 27793576.
      View in: PubMed
    20. Zisook S, Tal I, Weingart K, Hicks P, Davis LL, Chen P, Yoon J, Johnson GR, Vertrees JE, Rao S, Pilkinton PD, Wilcox JA, Sapra M, Iranmanesh A, Huang GD, Mohamed S. Characteristics of U.S. Veteran Patients with Major Depressive Disorder who require "next-step" treatments: A VAST-D report. J Affect Disord. 2016 Dec; 206:232-240. PMID: 27479536.
      View in: PubMed
    21. Atkinson JH, Slater MA, Capparelli EV, Patel SM, Wolfson T, Gamst A, Abramson IS, Wallace MS, Funk SD, Rutledge TR, Wetherell JL, Matthews SC, Zisook S, Garfin SR. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016 07; 157(7):1499-507. PMID: 26963844.
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    22. Shear MK, Reynolds CF, Simon NM, Zisook S, Wang Y, Mauro C, Duan N, Lebowitz B, Skritskaya N. Optimizing Treatment of Complicated Grief: A Randomized Clinical Trial. JAMA Psychiatry. 2016 Jul 01; 73(7):685-94. PMID: 27276373.
      View in: PubMed
    23. Martinez S, Tal I, Norcross W, Newton IG, Downs N, Seay K, McGuire T, Kirby B, Chidley B, Tiamson-Kassab M, Lee D, Hadley A, Doran N, Jong P, Lee K, Moutier C, Norman M, Zisook S. Alcohol use in an academic medical school environment: A UC San Diego Healer Education Assessment and Referral (HEAR) Report. Ann Clin Psychiatry. 2016 05; 28(2):85-94. PMID: 27285389.
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    24. Baker AW, Keshaviah A, Horenstein A, Goetter EM, Mauro C, Reynolds C, Zisook S, Shear MK, Simon NM. The role of avoidance in complicated grief: A detailed examination of the Grief-Related Avoidance Questionnaire (GRAQ) in a large sample of individuals with complicated grief. J Loss Trauma. 2016; 21(6):533-547. PMID: 28649184.
      View in: PubMed
    25. Mohamed S, Johnson GR, Vertrees JE, Guarino PD, Weingart K, Young IT, Yoon J, Gleason TC, Kirkwood KA, Kilbourne AM, Gerrity M, Marder S, Biswas K, Hicks P, Davis LL, Chen P, Kelada A, Huang GD, Lawrence DD, LeGwin M, Zisook S. The VA augmentation and switching treatments for improving depression outcomes (VAST-D) study: Rationale and design considerations. Psychiatry Res. 2015 Oct 30; 229(3):760-70. PMID: 26279130.
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    26. Bui E, Mauro C, Robinaugh DJ, Skritskaya NA, Wang Y, Gribbin C, Ghesquiere A, Horenstein A, Duan N, Reynolds C, Zisook S, Simon NM, Shear MK. THE STRUCTURED CLINICAL INTERVIEW FOR COMPLICATED GRIEF: RELIABILITY, VALIDITY, AND EXPLORATORY FACTOR ANALYSIS. Depress Anxiety. 2015 Jul; 32(7):485-92. PMID: 26061724.
      View in: PubMed
    27. Mills PJ, Wilson K, Iqbal N, Iqbal F, Alvarez M, Pung MA, Wachmann K, Rutledge T, Maglione J, Zisook S, Dimsdale JE, Lunde O, Greenberg BH, Maisel A, Raisinghani A, Natarajan L, Jain S, Hufford DJ, Redwine L. Depressive symptoms and spiritual wellbeing in asymptomatic heart failure patients. J Behav Med. 2015 Jun; 38(3):407-15. PMID: 25533643.
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    28. Zisook S, Iglewicz A, Avanzino J, Maglione J, Glorioso D, Zetumer S, Seay K, Vahia I, Young I, Lebowitz B, Pies R, Reynolds C, Simon N, Shear MK. Bereavement: course, consequences, and care. Curr Psychiatry Rep. 2014 Oct; 16(10):482. PMID: 25135781.
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    29. McClure JR, Criqui MH, Macera CA, Ji M, Nievergelt CM, Zisook S. Prevalence of suicidal ideation and other suicide warning signs in veterans attending an urgent care psychiatric clinic. Compr Psychiatry. 2015 Jul; 60:149-55. PMID: 25799463.
      View in: PubMed
    30. Bui E, Horenstein A, Shah R, Skritskaya NA, Mauro C, Wang Y, Duan N, Reynolds CF, Zisook S, Shear MK, Simon NM. Grief-related panic symptoms in Complicated Grief. J Affect Disord. 2015 Jan 01; 170:213-6. PMID: 25254619.
      View in: PubMed
    31. Zetumer S, Young I, Shear MK, Skritskaya N, Lebowitz B, Simon N, Reynolds C, Mauro C, Zisook S. The impact of losing a child on the clinical presentation of complicated grief. J Affect Disord. 2015 Jan 01; 170:15-21. PMID: 25217759.
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    32. Hall CA, Reynolds CF, Butters M, Zisook S, Simon N, Corey-Bloom J, Lebowitz BD, Begley A, Mauro C, Shear MK. Cognitive functioning in complicated grief. J Psychiatr Res. 2014 Nov; 58:20-5. PMID: 25088285.
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    33. Downs N, Feng W, Kirby B, McGuire T, Moutier C, Norcross W, Norman M, Young I, Zisook S. Listening to depression and suicide risk in medical students: the Healer Education Assessment and Referral (HEAR) Program. Acad Psychiatry. 2014 Oct; 38(5):547-53. PMID: 24705825.
      View in: PubMed
    34. Prabhakar D, Balon R, Anzia JM, Gabbard GO, Lomax JW, Bandstra BS, Eisen J, Figueroa S, Theresa G, Ruble M, Seritan AL, Zisook S. Helping psychiatry residents cope with patient suicide. Acad Psychiatry. 2014 Oct; 38(5):593-7. PMID: 24664605.
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    35. Warden D, Trivedi MH, Carmody T, Toups M, Zisook S, Lesser I, Myers A, Kurian KR, Morris D, Rush AJ. Adherence to antidepressant combinations and monotherapy for major depressive disorder: a CO-MED report of measurement-based care. J Psychiatr Pract. 2014 Mar; 20(2):118-32. PMID: 24638046.
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    36. Montross Thomas LP, Palinkas LA, Meier EA, Iglewicz A, Kirkland T, Zisook S. Yearning to be heard: what veterans teach us about suicide risk and effective interventions. Crisis. 2014; 35(3):161-7. PMID: 24698725.
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    37. Lee H, Iglewicz A, Golshan S, Zisook S. A tale of two veterans: homeless vs domiciled veterans presenting to a psychiatric urgent care clinic. Ann Clin Psychiatry. 2013 Nov; 25(4):275-82. PMID: 24199218.
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    38. Prabhakar D, Anzia JM, Balon R, Gabbard G, Gray E, Hatzis N, Lanouette NM, Lomax JW, Puri P, Zisook S. "Collateral damages": preparing residents for coping with patient suicide. Acad Psychiatry. 2013 Nov; 37(6):429-30. PMID: 23653109.
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    39. Iglewicz A, Seay K, Zetumer SD, Zisook S. The removal of the bereavement exclusion in the DSM-5: exploring the evidence. Curr Psychiatry Rep. 2013 Nov; 15(11):413. PMID: 24136623.
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    40. Zisook S, Pies R, Iglewicz A. Grief, depression, and the DSM-5. J Psychiatr Pract. 2013 Sep; 19(5):386-96. PMID: 24042244.
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    41. Wetherell JL, Petkus AJ, White KS, Nguyen H, Kornblith S, Andreescu C, Zisook S, Lenze EJ. Antidepressant medication augmented with cognitive-behavioral therapy for generalized anxiety disorder in older adults. Am J Psychiatry. 2013 Jul; 170(7):782-9. PMID: 23680817.
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    42. McGuire T, Moutier C, Downs N, Zisook S. In response to "Details on suicide among US physicians: data from the National Violent Death Reporting System". Gen Hosp Psychiatry. 2013 Jul-Aug; 35(4):448. PMID: 23567072.
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    43. Vahia IV, Lanouette NM, Golshan S, Fellows I, Mohamed S, Kasckow JW, Zisook S. Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms. Indian J Psychiatry. 2013 Apr; 55(2):144-8. PMID: 23825848.
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    44. Glick ID, Zisook S, Rapaport MH. Teaching the teacher: a report from the third annual American Society of Clinical Psychopharmacology teaching session. J Clin Psychiatry. 2013 Mar; 74(3):262-4. PMID: 23561232.
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    45. Zisook S, Boland R, Cowley D, Cyr RL, Pato MT, Thrall G. Teaching scholarly activity in psychiatric training: years 6 and 7. Acad Psychiatry. 2013 Mar 01; 37(2):82-6. PMID: 23475234.
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    46. Kasckow J, Golshan S, Zisook S. Does age moderate the relationship between depressive symptoms and suicidal ideation in middle-aged and older patients with schizophrenia and subthreshold depression? Am J Geriatr Psychiatry. 2014 May; 22(5):437-41. PMID: 23567374.
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    47. Zisook S, Shuchter SR. Major Depression Associated With Widowhood. Am J Geriatr Psychiatry. 1993 Autumn; 1(4):316-326. PMID: 28530910.
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    48. Cook IA, Hunter AM, Gilmer WS, Iosifescu DV, Zisook S, Burgoyne KS, Howland RH, Trivedi MH, Jain R, Greenwald S, Leuchter AF. Quantitative electroencephalogram biomarkers for predicting likelihood and speed of achieving sustained remission in major depression: a report from the biomarkers for rapid identification of treatment effectiveness in major depression (BRITE-MD) trial. J Clin Psychiatry. 2013 Jan; 74(1):51-6. PMID: 23419226.
      View in: PubMed
    49. Sung SC, Wisniewski SR, Balasubramani GK, Zisook S, Kurian B, Warden D, Trivedi MH, Rush AJ. Does early-onset chronic or recurrent major depression impact outcomes with antidepressant medications? A CO-MED trial report. Psychol Med. 2013 May; 43(5):945-60. PMID: 23228340.
      View in: PubMed
    50. Corruble E, Pies R, Zisook S. Grief in health care professionals: when screening for major depression is needed. Arch Intern Med. 2012 Dec 10; 172(22):1768; author reply 1768-9. PMID: 23229939.
      View in: PubMed
    51. Papakostas GI, Shelton RC, Zajecka JM, Etemad B, Rickels K, Clain A, Baer L, Dalton ED, Sacco GR, Schoenfeld D, Pencina M, Meisner A, Bottiglieri T, Nelson E, Mischoulon D, Alpert JE, Barbee JG, Zisook S, Fava M. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry. 2012 Dec; 169(12):1267-74. PMID: 23212058.
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    52. Prabhakar D, Balon R, Zisook S. Assessing the need for a multi-modal curriculum in psychopharmacology education. Acad Psychiatry. 2012 Nov 01; 36(6):497-9. PMID: 23154707.
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    53. Zisook S, Anzia J, Atri A, Baroni A, Clayton P, Haller E, Lomax JW, Mann JJ, Oquendo MA, Pato M, Perez-Rodriguez MM, Prabhakar D, Sen S, Thrall G, Yaseen ZS. Teaching evidence-based approaches to suicide risk assessment and prevention that enhance psychiatric training. Compr Psychiatry. 2013 Apr; 54(3):201-8. PMID: 22995449.
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    54. Deligiannidis KM, Girgis RR, Lau A, Balon R, Zisook S. Psychiatry resident/fellow-initiated and -designed multi-modal psychopharmacology curriculum for major depression. Acad Psychiatry. 2012 Sep 01; 36(5):414-8. PMID: 22983477.
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    55. Bourgeois JA, Yager J, Chisolm MS, Zisook S, Riba M, Levy BR, Newmark T, Aggarwal NK, Caplan JP, Balon R, Munro S, Pato MT. Why I like being an academic psychiatrist. Acad Psychiatry. 2012 Sep 01; 36(5):422-7. PMID: 22983479.
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    56. Tal Young I, Iglewicz A, Glorioso D, Lanouette N, Seay K, Ilapakurti M, Zisook S. Suicide bereavement and complicated grief. Dialogues Clin Neurosci. 2012 Jun; 14(2):177-86. PMID: 22754290.
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    57. Farabaugh A, Bitran S, Nyer M, Holt DJ, Pedrelli P, Shyu I, Hollon SD, Zisook S, Baer L, Busse W, Petersen TJ, Pender M, Tucker DD, Fava M. Depression and suicidal ideation in college students. Psychopathology. 2012; 45(4):228-34. PMID: 22627683.
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    58. Zisook S, Pies R, Corruble E. When is grief a disease? Lancet. 2012 Apr 28; 379(9826):1590. PMID: 22541582.
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    59. Zisook S, Corruble E, Duan N, Iglewicz A, Karam EG, Lanouette N, Lanuoette N, Lebowitz B, Pies R, Reynolds C, Seay K, Katherine Shear M, Simon N, Young IT. The bereavement exclusion and DSM-5. Depress Anxiety. 2012 May; 29(5):425-43. PMID: 22495967.
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    60. Dawes SE, Palmer BW, Meeks T, Golshan S, Kasckow J, Mohamed S, Zisook S. Does antidepressant treatment improve cognition in older people with schizophrenia or schizoaffective disorder and comorbid subsyndromal depression? Neuropsychobiology. 2012; 65(3):168-72. PMID: 22456094.
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    61. Moutier C, Norcross W, Jong P, Norman M, Kirby B, McGuire T, Zisook S. The suicide prevention and depression awareness program at the University of California, San Diego School of Medicine. Acad Med. 2012 Mar; 87(3):320-6. PMID: 22373625.
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    62. Fang DZ, Young CB, Golshan S, Moutier C, Zisook S. Erratum to Burnout in Premedical Undergraduate Students. Acad Psychiatry. 2012 Mar; 36(2):103. PMID: 27517451.
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    63. Davis LL, Pilkinton P, Wisniewski SR, Trivedi MH, Gaynes BN, Howland RH, Zisook S, Balasubramani GK, Fava M, Rush AJ. Effect of concurrent substance use disorder on the effectiveness of single and combination antidepressant medications for the treatment of major depression: an exploratory analysis of a single-blind randomized trial. Depress Anxiety. 2012 Feb; 29(2):111-22. PMID: 22495941.
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    64. Fang DZ, Fang D, Young CB, Young C, Golshan S, Moutier C, Zisook S. Burnout in premedical undergraduate students. Acad Psychiatry. 2012 Jan 01; 36(1):11-6. PMID: 22362430.
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    65. Zisook S, Downs N, Moutier C, Clayton P. College students and suicide risk: prevention and the role of academic psychiatry. Acad Psychiatry. 2012 Jan 01; 36(1):1-6. PMID: 22362428.
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    66. Rush AJ, Wisniewski SR, Zisook S, Fava M, Sung SC, Haley CL, Chan HN, Gilmer WS, Warden D, Nierenberg AA, Balasubramani GK, Gaynes BN, Trivedi MH, Hollon SD. Is prior course of illness relevant to acute or longer-term outcomes in depressed out-patients? A STAR*D report. Psychol Med. 2012 Jun; 42(6):1131-49. PMID: 22008447.
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    67. Lesser IM, Zisook S, Gaynes BN, Wisniewski SR, Luther JF, Fava M, Khan A, McGrath P, Warden D, Rush AJ, Trivedi M. Effects of race and ethnicity on depression treatment outcomes: the CO-MED trial. Psychiatr Serv. 2011 Oct; 62(10):1167-79. PMID: 21969643.
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    68. Zisook S, Lesser IM, Lebowitz B, Rush AJ, Kallenberg G, Wisniewski SR, Nierenberg AA, Fava M, Luther JF, Morris DW, Trivedi MH. Effect of antidepressant medication treatment on suicidal ideation and behavior in a randomized trial: an exploratory report from the Combining Medications to Enhance Depression Outcomes Study. J Clin Psychiatry. 2011 Oct; 72(10):1322-32. PMID: 22075098.
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    69. Friedman ES, Davis LL, Zisook S, Wisniewski SR, Trivedi MH, Fava M, Rush AJ. Baseline depression severity as a predictor of single and combination antidepressant treatment outcome: results from the CO-MED trial. Eur Neuropsychopharmacol. 2012 Mar; 22(3):183-99. PMID: 21920711.
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    70. Trivedi MH, Wisniewski SR, Morris DW, Fava M, Gollan JK, Warden D, Nierenberg AA, Gaynes BN, Husain MM, Luther JF, Zisook S, Rush AJ. Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk. J Clin Psychiatry. 2011 Jun; 72(6):757-64. PMID: 21733476.
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    71. Kasckow J, Montross L, Prunty L, Fox L, Zisook S. Suicidal behavior in the older patient with schizophrenia. Aging health. 2011 Jun; 7(3):379-393. PMID: 22028735.
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    72. Lanouette NM, Calabrese C, Sciolla AF, Bitner R, Mustata G, Haak J, Zisook S, Dunn LB. Do psychiatry residents identify as psychotherapists? A multisite survey. Ann Clin Psychiatry. 2011 Feb; 23(1):30-9. PMID: 21318194.
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    73. Kasckow J, Felmet K, Zisook S. Managing suicide risk in patients with schizophrenia. CNS Drugs. 2011 Feb; 25(2):129-43. PMID: 21254789.
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    74. Shear MK, Simon N, Wall M, Zisook S, Neimeyer R, Duan N, Reynolds C, Lebowitz B, Sung S, Ghesquiere A, Gorscak B, Clayton P, Ito M, Nakajima S, Konishi T, Melhem N, Meert K, Schiff M, O'Connor MF, First M, Sareen J, Bolton J, Skritskaya N, Mancini AD, Keshaviah A. Complicated grief and related bereavement issues for DSM-5. Depress Anxiety. 2011 Feb; 28(2):103-17. PMID: 21284063.
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    75. Zisook S, McQuaid JR, Sciolla A, Lanouette N, Calabrese C, Dunn LB. Psychiatric residents' interest in psychotherapy and training stage: a multi-site survey. Am J Psychother. 2011; 65(1):47-59. PMID: 21488519.
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    76. Felmet K, Zisook S, Kasckow JW. Elderly patients with schizophrenia and depression: diagnosis and treatment. Clin Schizophr Relat Psychoses. 2011 Jan; 4(4):239-50. PMID: 21177241.
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    77. Osatuke K, Reid M, Stiles WB, Kasckow JW, Zisook S, Mohamed S. Narrative evolution and assimilation of problematic experiences in a case of pharmacotherapy for schizophrenia. Psychother Res. 2011 Jan; 21(1):41-53. PMID: 20845225.
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    153. Summers J, Robinson R, Capps L, Zisook S, Atkinson JH, McCutchan E, McCutchan JA, Deutsch R, Patterson T, Grant I. The influence of HIV-related support groups on survival in women who lived with HIV. A pilot study. Psychosomatics. 2000 May-Jun; 41(3):262-8. PMID: 10849459.
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    158. Symonds LL, Archibald SL, Grant I, Zisook S, Jernigan TL. Does an increase in sulcal or ventricular fluid predict where brain tissue is lost? J Neuroimaging. 1999 Oct; 9(4):201-9. PMID: 10540599.
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    171. Fava M, Nierenberg AA, Quitkin FM, Zisook S, Pearlstein T, Stone A, Rosenbaum JF. A preliminary study on the efficacy of sertraline and imipramine on anger attacks in atypical depression and dysthymia. Psychopharmacol Bull. 1997; 33(1):101-3. PMID: 9133758.
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    172. Zisook S. Depression in late life. Diagnosis, course, and consequences. Postgrad Med. 1996 Oct; 100(4):143-8, 150, 156. PMID: 8858088.
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    174. Schneider DS, Sledge PA, Shuchter SR, Zisook S. Dating and remarriage over the first two years of widowhood. Ann Clin Psychiatry. 1996 Jun; 8(2):51-7. PMID: 8807029.
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    175. Rapaport MH, Zisook S, Frevert T, Seymour S, Kelsoe JR, Judd LL. A comparison of descriptive variables for clinical patients and symptomatic volunteers with depressive disorders. J Clin Psychopharmacol. 1996 Jun; 16(3):242-6. PMID: 8784657.
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    176. Rapaport MH, Frevert T, Babior S, Seymour S, Zisook S, Kelsoe J, Judd LL. Comparison of descriptive variables for symptomatic volunteers and clinical patients with anxiety disorders. Anxiety. 1996; 2(3):117-22. PMID: 9160612.
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    177. Zisook S, Byrd D, Kuck J, Jeste DV. Command hallucinations in outpatients with schizophrenia. J Clin Psychiatry. 1995 Oct; 56(10):462-5. PMID: 7559372.
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    178. Andia AM, Zisook S, Heaton RK, Hesselink J, Jernigan T, Kuck J, Morganville J, Braff DL. Gender differences in schizophrenia. J Nerv Ment Dis. 1995 Aug; 183(8):522-8. PMID: 7643064.
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    179. Summers J, Zisook S, Atkinson JH, Sciolla A, Whitehall W, Brown S, Patterson T, Grant I. Psychiatric morbidity associated with acquired immune deficiency syndrome-related grief resolution. J Nerv Ment Dis. 1995 Jun; 183(6):384-9. PMID: 7798087.
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    180. Rapaport MH, Frevert T, Babior S, Zisook S, Judd LL. A comparison of demographic variables, symptom profiles, and measurements of functioning in symptomatic volunteers and an outpatient clinical population. Psychopharmacol Bull. 1995; 31(1):111-4. PMID: 7675974.
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    181. Paulsen JS, Heaton RK, Sadek JR, Perry W, Delis DC, Braff D, Kuck J, Zisook S, Jeste DV. The nature of learning and memory impairments in schizophrenia. J Int Neuropsychol Soc. 1995 Jan; 1(1):88-99. PMID: 9375213.
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    182. Heaton R, Paulsen JS, McAdams LA, Kuck J, Zisook S, Braff D, Harris J, Jeste DV. Neuropsychological deficits in schizophrenics. Relationship to age, chronicity, and dementia. Arch Gen Psychiatry. 1994 Jun; 51(6):469-76. PMID: 8192549.
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    183. Clementz BA, McDowell JE, Zisook S. Saccadic system functioning among schizophrenia patients and their first-degree biological relatives. J Abnorm Psychol. 1994 May; 103(2):277-87. PMID: 8040497.
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    184. Zisook S, Shuchter SR, Irwin M, Darko DF, Sledge P, Resovsky K. Bereavement, depression, and immune function. Psychiatry Res. 1994 Apr; 52(1):1-10. PMID: 8047615.
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    185. Zisook S, Shuchter SR, Sledge PA, Paulus M, Judd LL. The spectrum of depressive phenomena after spousal bereavement. J Clin Psychiatry. 1994 Apr; 55 Suppl:29-36. PMID: 8077167.
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    186. Zisook S, Goff A, Sledge P, Shuchter SR. Reported suicidal behavior and current suicidal ideation in a psychiatric outpatient clinic. Ann Clin Psychiatry. 1994 Mar; 6(1):27-31. PMID: 7951642.
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    187. Alexopoulos G, Caine ED, Katz I, Lyness JM, Merikangas KR, Pearson JL, Prigerson H, Reynolds CF, Schneider LS, Zisook S, Zubenko GS, Lebowitz BD, Kupfer DJ. Participants in the workshop. Am J Geriatr Psychiatry. 1994; 2(1):4-8. PMID: 21629001.
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    188. Zisook S, Shuchter SR. Uncomplicated bereavement. J Clin Psychiatry. 1993 Oct; 54(10):365-72. PMID: 8262878.
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    189. Zisook S, Shuchter SR, Sledge P, Mulvihill M. Aging and bereavement. J Geriatr Psychiatry Neurol. 1993 Jul-Sep; 6(3):137-43. PMID: 8397757.
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    190. Swerdlow NR, Benbow CH, Zisook S, Geyer MA, Braff DL. A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder. Biol Psychiatry. 1993 Feb 15; 33(4):298-301. PMID: 8471686.
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    191. Kuck J, Zisook S, Moranville JT, Heaton RK, Braff DL. Negative symptomatology in schizophrenic outpatients. J Nerv Ment Dis. 1992 Aug; 180(8):510-5. PMID: 1500933.
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    192. Zisook S, Heaton R, Moranville J, Kuck J, Jernigan T, Braff D. Past substance abuse and clinical course of schizophrenia. Am J Psychiatry. 1992 Apr; 149(4):552-3. PMID: 1554046.
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    193. Zisook S, Shuchter SR. Early psychological reaction to the stress of widowhood. Psychiatry. 1991 Nov; 54(4):320-33. PMID: 1788363.
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    194. Braff DL, Heaton R, Kuck J, Cullum M, Moranville J, Grant I, Zisook S. The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test results. Arch Gen Psychiatry. 1991 Oct; 48(10):891-8. PMID: 1929758.
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    195. Jernigan TL, Zisook S, Heaton RK, Moranville JT, Hesselink JR, Braff DL. Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Arch Gen Psychiatry. 1991 Oct; 48(10):881-90. PMID: 1929757.
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    196. Zisook S, Shuchter SR. Depression through the first year after the death of a spouse. Am J Psychiatry. 1991 Oct; 148(10):1346-52. PMID: 1897615.
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    197. Davidson JR, Giller EL, Zisook S, Helms MJ. Predictors of response to monoamine oxidase inhibitors: do they exist? Eur Arch Psychiatry Clin Neurosci. 1991; 241(3):181-6. PMID: 1824048.
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    198. Hintz S, Kuck J, Peterkin JJ, Volk DM, Zisook S. Depression in the context of human immunodeficiency virus infection: implications for treatment. J Clin Psychiatry. 1990 Dec; 51(12):497-501. PMID: 2258363.
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    199. Zisook S, Mulvihill M, Shuchter SR. Widowhood and anxiety. Psychiatr Med. 1990; 8(4):99-116. PMID: 1982370.
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    200. Zisook S, Schneider D, Shuchter SR. Anxiety and bereavement. Psychiatr Med. 1990; 8(2):83-96. PMID: 2185504.
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    201. Davidson JR, Woodbury MA, Zisook S, Giller EL. Classification of depression by grade of membership: a confirmation study. Psychol Med. 1989 Nov; 19(4):987-98. PMID: 2594894.
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    202. Davidson J, Zisook S, Giller E, Helms M. Symptoms of interpersonal sensitivity in depression. Compr Psychiatry. 1989 Sep-Oct; 30(5):357-68. PMID: 2676337.
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    203. Ornish SA, Zisook S, McAdams LA. Effects of transdermal clonidine treatment on withdrawal symptoms associated with smoking cessation. A randomized, controlled trial. Arch Intern Med. 1988 Sep; 148(9):2027-31. PMID: 3046542.
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    204. Shuchter SR, Zisook S. Widowhood. The continuing relationship with the dead spouse. Bull Menninger Clin. 1988 May; 52(3):269-79. PMID: 3382825.
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    205. Braff DL, Glick ID, Johnson MH, Zisook S. The clinical significance of thought disorder across time in psychiatric patients. J Nerv Ment Dis. 1988 Apr; 176(4):213-20. PMID: 3351500.
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    206. Rockwell E, Lam RW, Zisook S. Antidepressant drug studies in the elderly. Psychiatr Clin North Am. 1988 Mar; 11(1):215-33. PMID: 2898134.
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    207. Ruegg RG, Zisook S, Swerdlow NR. Depression in the aged. An overview. Psychiatr Clin North Am. 1988 Mar; 11(1):83-99. PMID: 3288982.
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    208. Davidson JR, Giller EL, Zisook S, Overall JE. An efficacy study of isocarboxazid and placebo in depression, and its relationship to depressive nosology. Arch Gen Psychiatry. 1988 Feb; 45(2):120-7. PMID: 3276281.
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    209. Rapaport MH, Zisook S, Lyons LE. Factors influencing outpatient attrition. Psychiatr Med. 1988; 6(4):41-54. PMID: 3238027.
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    210. Zisook S. Delirium. Psychiatr Med. 1988; 6(4):8-22. PMID: 3238030.
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    211. Zisook S. Cyclic 48-hour unipolar depression. J Nerv Ment Dis. 1988 Jan; 176(1):53-6. PMID: 3121783.
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    212. Zisook S, Ricketts JE. Psychopharmacologic approaches to the borderline patient. Hillside J Clin Psychiatry. 1988; 10(1):55-70. PMID: 2900799.
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    213. Jacobs SC, Nelson JC, Zisook S. Treating depressions of bereavement with antidepressants. A pilot study. Psychiatr Clin North Am. 1987 Sep; 10(3):501-10. PMID: 3684751.
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    214. Zisook S, Shuchter SR, Lyons LE. Predictors of psychological reactions during the early stages of widowhood. Psychiatr Clin North Am. 1987 Sep; 10(3):355-68. PMID: 3684745.
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    215. Zisook S, Schuckit MA. Male primary alcoholics with and without family histories of affective disorder. J Stud Alcohol. 1987 Jul; 48(4):337-44. PMID: 3613585.
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    216. Rapaport MH, Zisook S. Requests by walk-in and scheduled patients at an outpatient clinic. Walk-in needs more varied and greater in number. Psychosomatics. 1987 Mar; 28(3):129-32, 141-2. PMID: 3432531.
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    217. Zisook S, Mendels J, Janowsky D, Feighner J, Lee JC, Fritz A. Efficacy and safety of fezolamine in depressed patients. Neuropsychobiology. 1987; 17(3):133-8. PMID: 3683802.
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    218. Shuchter SR, Zisook S, Kirkorowicz C, Risch C. The dexamethasone suppression test in acute grief. Am J Psychiatry. 1986 Jul; 143(7):879-81. PMID: 3717428.
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    219. Zisook S, Braff DL. Delirium: recognition and management in the older patient. Geriatrics. 1986 Jun; 41(6):67-7O, 72-3, 77-8. PMID: 2872139.
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    220. Shuchter S, Zisook S. Group crisis intervention following the PSA crash. Psychiatr Med. 1986; 4(1):93-101. PMID: 3432574.
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    221. Schuckit MA, Zisook S, Mortola J. Clinical implications of DSM-III diagnoses of alcohol abuse and alcohol dependence. Am J Psychiatry. 1985 Dec; 142(12):1403-8. PMID: 4073301.
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    222. Zisook S, Janowsky DS, Overall JE, Risch SC. The dexamethasone suppression test and unipolar/bipolar distinctions. J Clin Psychiatry. 1985 Nov; 46(11):461-5. PMID: 4055705.
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    223. Zisook S, Braff DL, Click MA. Monoamine oxidase inhibitors in the treatment of atypical depression. J Clin Psychopharmacol. 1985 Jun; 5(3):131-7. PMID: 3889078.
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    224. Zisook S, Shuchter S, Schuckit M. Factors in the persistence of unresolved grief among psychiatric outpatients. Psychosomatics. 1985 Jun; 26(6):497-9, 503. PMID: 4011815.
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    225. Zisook S, Shuchter SR. Time course of spousal bereavement. Gen Hosp Psychiatry. 1985 Apr; 7(2):95-100. PMID: 3996909.
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    226. Zisook S. A clinical overview of monoamine oxidase inhibitors. Psychosomatics. 1985 Mar; 26(3):240-6, 251. PMID: 3887453.
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    227. Zisook S, DeVaul R. Unresolved grief. Am J Psychoanal. 1985; 45(4):370-9. PMID: 4083364.
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    228. Zisook S. A multiple site psychiatry clinical clerkship. Psychiatr Med. 1984 Dec; 2(4):355-69. PMID: 6599907.
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    229. Zisook S. Side effects of isocarboxazid. J Clin Psychiatry. 1984 Jul; 45(7 Pt 2):53-8. PMID: 6376485.
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    230. Zisook S, DeVaul R. Measuring acute grief. Psychiatr Med. 1984 Jun; 2(2):169-76. PMID: 6571620.
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    231. Janowsky D, Curtis G, Zisook S, Kuhn K, Resovsky K, Le Winter M. Trazodone-aggravated ventricular arrhythmias. J Clin Psychopharmacol. 1983 Dec; 3(6):372-6. PMID: 6196381.
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    232. Janowsky D, Curtis G, Zisook S, Kuhn K, Resovsky K, Le Winter M. Ventricular arrhythmias possibly aggravated by trazodone. Am J Psychiatry. 1983 Jun; 140(6):796-7. PMID: 6189410.
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    233. Zisook S. Isocarboxazid in the treatment of depression. Am J Psychiatry. 1983 Jun; 140(6):792-4. PMID: 6342428.
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    234. Zisook S, DeVaul RA. Grief, unresolved grief, and depression. Psychosomatics. 1983 Mar; 24(3):247-56. PMID: 6844538.
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    235. Zisook S, Devaul RA, Click MA. Measuring symptoms of grief and bereavement. Am J Psychiatry. 1982 Dec; 139(12):1590-3. PMID: 7149059.
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    236. Click MA, Zisook S. Amoxapine and amitriptyline: serum levels and clinical response in patients with primary unipolar depression. J Clin Psychiatry. 1982 Sep; 43(9):369-71. PMID: 6749828.
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    237. Zisook S, Overall JE, Click MA. Treatment validity of different diagnostic concepts of depression. Psychiatry Res. 1981 Aug; 5(1):77-85. PMID: 7025075.
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    238. Lloyd C, Zisook S, Click M, Jaffe KE. Life events and response to antidepressants. J Human Stress. 1981 Mar; 7(1):2-15. PMID: 7204956.
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    239. Hall RC, Zisook S. Paradoxical reactions to benzodiazepines. Br J Clin Pharmacol. 1981; 11 Suppl 1:99S-104S. PMID: 6133541.
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    240. Overall JE, Zisook S. Diagnosis and the phenomenology of depressive disorders. J Consult Clin Psychol. 1980 Oct; 48(5):626-34. PMID: 7410661.
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    241. Overall JE, Zisook S. Diagnosis and the phenomenology of depressive disorder. Psychopharmacol Bull. 1980 Jul; 16(3):25-7. PMID: 7403393.
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    242. Zisook S, Hall RC, Gammon E. Drug treatment of depression: a classification system for agent selection. Postgrad Med. 1980 May; 67(5):153-6, 159, 161. PMID: 6103532.
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    243. Gammon E, Zisook S. Student evaluations of a required sex education course. J Med Educ. 1980 Apr; 55(4):372-4. PMID: 7365779.
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    244. Zisook S, Click M, Jaffe K, Overall JE. Research criteria for the diagnosis of depression. Psychiatry Res. 1980 Mar; 2(1):13-23. PMID: 6932052.
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    245. Zisook S, Click MA. Evaluations of loxapine succinate in the ambulatory treatment of acute schizophrenic episodes. Int Pharmacopsychiatry. 1980; 15(6):365-78. PMID: 7028656.
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    246. Zisook S, Gammon E. Medical noncompliance. Int J Psychiatry Med. 1980-1981; 10(4):291-301. PMID: 7009458.
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    247. DeVaul RA, Zisook S, Faschingbauer TR. Clinical aspects of grief and bereavement. Prim Care. 1979 Jun; 6(2):391-402. PMID: 258819.
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    248. Zisook S, Lloyd C, Click M. Teaching and evaluating interviewing. J Med Educ. 1979 Feb; 54(2):117-9. PMID: 762691.
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    249. Zisook S, DeVaul RA, Gammon E. The hysterical facade. Am J Psychoanal. 1979; 39(2):113-23. PMID: 495816.
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    250. Zisook S, DeVaul RA. The hysterical personality--I. The healthy hysteric. Br J Med Psychol. 1978 Dec; 51(4):363-8. PMID: 737148.
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    251. Jaffe K, Zisook S. Galactorrhea in a patient treated with amoxapine. J Clin Psychiatry. 1978 Nov; 39(11):821. PMID: 569147.
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    252. Zisook S, Rogers PJ, Faschingbauer TR, Devaul RA. Absence of hostility in outpatients after administration of halazepam--a new benzodiazepine. J Clin Psychiatry. 1978 Aug; 39(8):683-5. PMID: 681309.
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    253. DeVaul RA, Zisook S. Chronic pain: the psychiatrist's role. Psychosomatics. 1978 Jul; 19(7):417-21. PMID: 684141.
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    254. Zisook S, Hammond R, Jaffe K, Gammon E. Outpatient requests, initial sessions and attrition. Int J Psychiatry Med. 1978-1979; 9(3-4):339-50. PMID: 757223.
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    255. Zisook S, DeVaul RA. Adverse behavioral effects of benzodiazepines. J Fam Pract. 1977 Dec; 5(6):963-6. PMID: 22578.
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    256. DeVaul RA, Zisook S. Reversible organic brain syndrome: clues to quick recognition. Med Times. 1977 Aug; 105(8):(80)9d-(80)15d. PMID: 886938.
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    257. Zisook S, DeVaul RA. Emotional factors in inflammatory bowel disease. South Med J. 1977 Jun; 70(6):716-9. PMID: 877623.
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    258. Faschingbauer TR, Devaul RA, Zisook S. Development of the Texas Inventory of Grief. Am J Psychiatry. 1977 Jun; 134(6):696-8. PMID: 869041.
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    259. De Vaul RA, Zisook S, Stuart HJ. Patients with psychogenic pain. J Fam Pract. 1977 Jan; 4(1):53-5. PMID: 833561.
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    260. DeVaul RA, Zisook S. Psychiatry: unresolved grief. Clinical considerations. Postgrad Med. 1976 May; 59(5):267-71. PMID: 1264920.
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    261. Zisook S, de Vaul RA. Grief-related facsimile illness. Int J Psychiatry Med. 1976-1977; 7(4):329-36. PMID: 1052207.
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    262. Lazare A, Cohen F, Jacobson AM, Williams MW, Mignone RJ, Zisook S. The walk-in patient as a 'customer': a key dimension in evaluation and treatment. Am J Orthopsychiatry. 1972 Oct; 42(5):872-83. PMID: 4653323.
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    263. Zisook S. Ulcerative colitis: case responding to treatment with lithium carbonate. JAMA. 1972 Feb; 219(6):755. PMID: 5066706.
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