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    Joshua Kuperman

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentRadiology
    Address9500 Gilman Drive #0841
    CA La Jolla 92093
    Phone858-534-4999
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      UCSDPostdoctoral ScholarMR Imaging
      UCSDPh.D.2003Chemistry
      UCSDM.S.1999Chemistry
      Carleton CollegeB.A.1996Chemistry
      University College London1995Neurosciences

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Reas ET, Hagler DJ, White NS, Kuperman J, Bartsch H, Cross K, Loi RQ, Balachandra AR, Meloy MJ, Wierenga CE, Galasko D, Brewer JB, Dale AM, McEvoy LK. Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer's disease. Alzheimers Res Ther. 2017 Aug 02; 9(1):55. PMID: 28764771.
        View in: PubMed
      2. Fan CC, Brown TT, Bartsch H, Kuperman J, Hagler DJ, Schork A, Searcy Y, Bellugi U, Halgren E, Dale AM. Williams syndrome-specific neuroanatomical profile and its associations with behavioral features. Neuroimage Clin. 2017; 15:343-347. PMID: 28560159.
        View in: PubMed
      3. Karunamuni RA, White NS, McDonald CR, Connor M, Pettersson N, Seibert TM, Kuperman J, Farid N, Moiseenko V, Dale AM, Hattangadi-Gluth JA. Multi-component diffusion characterization of radiation-induced white matter damage. Med Phys. 2017 May; 44(5):1747-1754. PMID: 28222217.
        View in: PubMed
      4. Krishnan AP, Karunamuni R, Leyden KM, Seibert TM, Delfanti RL, Kuperman J, Bartsch H, Elbe P, Srikant A, Dale AM, Kesari S, Piccioni DE, Hattangadi-Gluth JA, Farid N, McDonald CR, White NS. Restriction Spectrum Imaging Improves Risk Stratification in Patients with Glioblastoma. AJNR Am J Neuroradiol. 2017 May; 38(5):882-889. PMID: 28279985.
        View in: PubMed
      5. Seibert TM, Karunamuni R, Bartsch H, Kaifi S, Krishnan AP, Dalia Y, Burkeen J, Murzin V, Moiseenko V, Kuperman J, White NS, Brewer JB, Farid N, McDonald CR, Hattangadi-Gluth JA. Radiation Dose-Dependent Hippocampal Atrophy Detected With Longitudinal Volumetric Magnetic Resonance Imaging. Int J Radiat Oncol Biol Phys. 2017 Feb 01; 97(2):263-269. PMID: 28068234.
        View in: PubMed
      6. Connor M, Karunamuni R, McDonald C, White N, Pettersson N, Moiseenko V, Seibert T, Marshall D, Cervino L, Bartsch H, Kuperman J, Murzin V, Krishnan A, Farid N, Dale A, Hattangadi-Gluth J. Dose-dependent white matter damage after brain radiotherapy. Radiother Oncol. 2016 Nov; 121(2):209-216. PMID: 27776747.
        View in: PubMed
      7. Newman E, Jernigan TL, Lisdahl KM, Tamm L, Tapert SF, Potkin SG, Mathalon D, Molina B, Bjork J, Castellanos FX, Swanson J, Kuperman J, Bartsch H, Chen CH, Dale AM, Epstein JN, Group MN. Go/No Go task performance predicts cortical thickness in the caudal inferior frontal gyrus in young adults with and without ADHD. Brain Imaging Behav. 2016 Sep; 10(3):880-92. PMID: 26404018; PMCID: PMC4808505 [Available on 09/01/17].
      8. Brunsing RL, Schenker-Ahmed NM, White NS, Parsons JK, Kane C, Kuperman J, Bartsch H, Kader AK, Rakow-Penner R, Seibert TM, Margolis D, Raman SS, McDonald CR, Farid N, Kesari S, Hansel D, Shabaik A, Dale AM, Karow DS. Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI. J Magn Reson Imaging. 2017 Feb; 45(2):323-336. PMID: 27527500.
        View in: PubMed
      9. Hope TR, White NS, Kuperman J, Chao Y, Yamin G, Bartch H, Schenker-Ahmed NM, Rakow-Penner R, Bussell R, Nomura N, Kesari S, Bjørnerud A, Dale AM. Demonstration of Non-Gaussian Restricted Diffusion in Tumor Cells Using Diffusion Time-Dependent Diffusion-Weighted Magnetic Resonance Imaging Contrast. Front Oncol. 2016; 6:179. PMID: 27532028; PMCID: PMC4970563.
      10. Braddick O, Atkinson J, Newman E, Akshoomoff N, Kuperman J, Bartsch H, Chen CH, Dale AM, Jernigan TL. Global Visual Motion Sensitivity: Associations with Parietal Area and Children's Mathematical Cognition. J Cogn Neurosci. 2016 Dec; 28(12):1897-1908. PMID: 27458748.
        View in: PubMed
      11. Seibert TM, White NS, Kim GY, Moiseenko V, McDonald CR, Farid N, Bartsch H, Kuperman J, Karunamuni R, Marshall D, Holland D, Sanghvi P, Simpson DR, Mundt AJ, Dale AM, Hattangadi-Gluth JA. Distortion inherent to magnetic resonance imaging can lead to geometric miss in radiosurgery planning. Pract Radiat Oncol. 2016 Nov - Dec; 6(6):e319-e328. PMID: 27523440.
        View in: PubMed
      12. Yamin G, Schenker-Ahmed NM, Shabaik A, Adams D, Bartsch H, Kuperman J, White NS, Rakow-Penner RA, McCammack K, Parsons JK, Kane CJ, Dale AM, Karow DS. Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index with Gleason Grade in Prostate Cancer. Clin Cancer Res. 2016 Jun 01; 22(11):2668-74. PMID: 27250935; PMCID: PMC4896066 [Available on 06/01/17].
      13. McCammack KC, Schenker-Ahmed NM, White NS, Best SR, Marks RM, Heimbigner J, Kane CJ, Parsons JK, Kuperman J, Bartsch H, Desikan RS, Rakow-Penner RA, Liss MA, Margolis DJ, Raman SS, Shabaik A, Dale AM, Karow DS. Restriction spectrum imaging improves MRI-based prostate cancer detection. Abdom Radiol (NY). 2016 May; 41(5):946-53. PMID: 26910114.
        View in: PubMed
      14. McDonald CR, Delfanti RL, Krishnan AP, Leyden KM, Hattangadi-Gluth JA, Seibert TM, Karunamuni R, Elbe P, Kuperman J, Bartsch H, Piccioni DE, White NS, Dale AM, Farid N. Restriction spectrum imaging predicts response to bevacizumab in patients with high-grade glioma. Neuro Oncol. 2016 Nov; 18(11):1579-1590. PMID: 27106406.
        View in: PubMed
      15. Eicher JD, Montgomery AM, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman J, Brown TT, Hagler DJ, Dale AM, Jernigan TL, Gruen JR. Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children. Brain Imaging Behav. 2016 Mar; 10(1):272-82. PMID: 25953057; PMCID: PMC4639472.
      16. Karunamuni RA, Moore KL, Seibert TM, Li N, White NS, Bartsch H, Carmona R, Marshall D, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell LK, Brewer J, Dale AM, Moiseenko V, Hattangadi-Gluth JA. Radiation sparing of cerebral cortex in brain tumor patients using quantitative neuroimaging. Radiother Oncol. 2016 Jan; 118(1):29-34. PMID: 26806266; PMCID: PMC4764402 [Available on 01/21/17].
      17. McCammack KC, Kane CJ, Parsons JK, White NS, Schenker-Ahmed NM, Kuperman J, Bartsch H, Desikan RS, Rakow-Penner RA, Adams D, Liss MA, Mattrey RF, Bradley WG, Margolis DJ, Raman SS, Shabaik A, Dale AM, Karow DS. In vivo prostate cancer detection and grading using restriction spectrum imaging-MRI. Prostate Cancer Prostatic Dis. 2016 06; 19(2):168-73. PMID: 26754261.
        View in: PubMed
      18. Karunamuni R, Bartsch H, White NS, Moiseenko V, Carmona R, Marshall DC, Seibert TM, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell L, Brewer JB, Dale AM, Hattangadi-Gluth JA. Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma. Int J Radiat Oncol Biol Phys. 2016 Feb 01; 94(2):297-304. PMID: 26853338; PMCID: PMC4747044 [Available on 02/01/17].
      19. Newman E, Thompson WK, Bartsch H, Hagler DJ, Chen CH, Brown TT, Kuperman J, McCabe C, Chung Y, Libiger O, Akshoomoff N, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Murray SS, Sowell ER, Schork N, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM, Jernigan TL. Anxiety is related to indices of cortical maturation in typically developing children and adolescents. Brain Struct Funct. 2016 Jul; 221(6):3013-25. PMID: 26183468.
        View in: PubMed
      20. Fan CC, Bartsch H, Schork AJ, Chen CH, Wang Y, Lo MT, Brown TT, Kuperman J, Hagler DJ, Schork NJ, Jernigan TL, Dale AM. Modeling the 3D geometry of the cortical surface with genetic ancestry. Curr Biol. 2015 Aug 03; 25(15):1988-92. PMID: 26166778; PMCID: PMC4786069.
      21. Jernigan TL, Brown TT, Hagler DJ, Akshoomoff N, Bartsch H, Newman E, Thompson WK, Bloss CS, Murray SS, Schork N, Kennedy DN, Kuperman J, McCabe C, Chung Y, Libiger O, Maddox M, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Sowell ER, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM. The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. Neuroimage. 2016 Jan 01; 124(Pt B):1149-54. PMID: 25937488; PMCID: PMC4628902 [Available on 01/01/17].
      22. Noble KG, Houston SM, Brito NH, Bartsch H, Kan E, Kuperman J, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Murray SS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Van Zijl P, Mostofsky S, Kaufmann WE, Kenet T, Dale AM, Jernigan TL, Sowell ER. Family income, parental education and brain structure in children and adolescents. Nat Neurosci. 2015 May; 18(5):773-8. PMID: 25821911; PMCID: PMC4414816.
      23. Liss MA, White NS, Parsons JK, Schenker-Ahmed NM, Rakow-Penner R, Kuperman J, Bartsch H, Choi HW, Mattrey RF, Bradley WG, Shabaik A, Huang J, Margolis DJ, Raman SS, Marks LS, Kane CJ, Reiter RE, Dale AM, Karow DS. MRI-Derived Restriction Spectrum Imaging Cellularity Index is Associated with High Grade Prostate Cancer on Radical Prostatectomy Specimens. Front Oncol. 2015; 5:30. PMID: 25741473; PMCID: PMC4330697.
      24. Rakow-Penner RA, White NS, Parsons JK, Choi HW, Liss MA, Kuperman J, Schenker-Ahmed N, Bartsch H, Mattrey RF, Bradley WG, Shabaik A, Huang J, Margolis DJ, Raman SS, Marks L, Kane CJ, Reiter RE, Karow DS, Dale AM. Novel technique for characterizing prostate cancer utilizing MRI restriction spectrum imaging: proof of principle and initial clinical experience with extraprostatic extension. Prostate Cancer Prostatic Dis. 2015 Mar; 18(1):81-5. PMID: 25559097.
        View in: PubMed
      25. Holland D, Chang L, Ernst TM, Curran M, Buchthal SD, Alicata D, Skranes J, Johansen H, Hernandez A, Yamakawa R, Kuperman J, Dale AM. Structural growth trajectories and rates of change in the first 3 months of infant brain development. JAMA Neurol. 2014 Oct; 71(10):1266-74. PMID: 25111045; PMCID: PMC4940157.
      26. White NS, McDonald C, McDonald CR, Farid N, Kuperman J, Karow D, Schenker-Ahmed NM, Bartsch H, Rakow-Penner R, Holland D, Shabaik A, Bjørnerud A, Hope T, Hattangadi-Gluth J, Liss M, Parsons JK, Chen CC, Raman S, Margolis D, Reiter RE, Marks L, Kesari S, Mundt AJ, Kane CJ, Kaine CJ, Carter BS, Bradley WG, Dale AM. Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging. Cancer Res. 2014 Sep 01; 74(17):4638-52. PMID: 25183788; PMCID: PMC4155409.
      27. Farid N, Almeida-Freitas DB, White NS, McDonald CR, Kuperman J, Almutairi AA, Muller KA, VandenBerg SR, Kesari S, Dale AM. Combining diffusion and perfusion differentiates tumor from bevacizumab-related imaging abnormality (bria). J Neurooncol. 2014 Dec; 120(3):539-46. PMID: 25135423.
        View in: PubMed
      28. Eicher JD, Powers NR, Miller LL, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman J, Brown TT, Hagler DJ, Dale AM, Jernigan TL, St Pourcain B, Davey Smith G, Ring SM, Gruen JR. Genome-wide association study of shared components of reading disability and language impairment. Genes Brain Behav. 2013 Nov; 12(8):792-801. PMID: 24024963; PMCID: PMC3904347.
      29. McDonald CR, White NS, Farid N, Lai G, Kuperman J, Bartsch H, Hagler DJ, Kesari S, Carter BS, Chen CC, Dale AM. Recovery of white matter tracts in regions of peritumoral FLAIR hyperintensity with use of restriction spectrum imaging. AJNR Am J Neuroradiol. 2013 Jun-Jul; 34(6):1157-63. PMID: 23275591; PMCID: PMC3928241.
      30. Walhovd KB, Fjell AM, Brown TT, Kuperman J, Chung Y, Hagler DJ, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst TM, Frazier J, Gruen JR, Kaufmann WE, Murray SS, van Zijl P, Mostofsky S, Dale AM. Long-term influence of normal variation in neonatal characteristics on human brain development. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):20089-94. PMID: 23169628; PMCID: PMC3523836.
      31. Fjell AM, Walhovd KB, Brown TT, Kuperman J, Chung Y, Hagler DJ, Venkatraman V, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Darst BF, Schork NJ, Casey BJ, Chang L, Ernst TM, Gruen JR, Kaufmann WE, Kenet T, Frazier J, Murray SS, Sowell ER, van Zijl P, Mostofsky S, Jernigan TL, Dale AM. Multimodal imaging of the self-regulating developing brain. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19620-5. PMID: 23150548; PMCID: PMC3511748.
      32. White NS, McDonald CR, Farid N, Kuperman J, Kesari S, Dale AM. Improved conspicuity and delineation of high-grade primary and metastatic brain tumors using "restriction spectrum imaging": quantitative comparison with high B-value DWI and ADC. AJNR Am J Neuroradiol. 2013 May; 34(5):958-64, S1. PMID: 23139079; PMCID: PMC4146398.
      33. Brown TT, Kuperman J, Chung Y, Erhart M, McCabe C, Hagler DJ, Venkatraman VK, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kaufmann WE, Kenet T, Kennedy DN, Murray SS, Sowell ER, Jernigan TL, Dale AM. Neuroanatomical assessment of biological maturity. Curr Biol. 2012 Sep 25; 22(18):1693-8. PMID: 22902750; PMCID: PMC3461087.
      34. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM, Weiner M, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Liu E, Montine T, Gamst A, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Harvey D, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe RA, Foster N, Reiman EM, Chen K, Mathis C, Cairns NJ, Taylor-Reinwald L, Trojanowki JQ, Shaw L, Lee VM, Korecka M, Crawford K, Neu S, Foroud TM, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder PJ, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider LS, Pawluczyk S, Spann BM, Brewer J, Vanderswag H, Heidebrink JL, Lord JL, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig LS, Bell KL, Morris JC, Ances B, Carroll M, Leon S, Mintun MA, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah RC, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon MJ, Glodzik L, De Santi S, Doraiswamy PM, Petrella JR, Coleman RE, Arnold SE, Karlawish JH, Wolk D, Smith CD, Jicha G, Hardy P, Lopez OL, Oakley M, Simpson DM, Porsteinsson AP, Goldstein BS, Martin K, Makino KM, Ismail MS, Brand C, Mulnard RA, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Swerdlow RH, Apostolova L, Lu PH, Bartzokis G, Silverman DH, Graff-Radford NR, Parfitt F, Johnson H, Farlow MR, Hake AM, Matthews BR, Herring S, van Dyck CH, Carson RE, MacAvoy MG, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung R, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam MM, Lipowski K, Wu CK, Johnson N, Sadowsky C, Martinez W, Villena T, Turner RS, Johnson K, Reynolds B, Sperling RA, Johnson KA, Marshall G, Frey M, Yesavage J, Taylor JL, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson AE, Norbash A, Johnson PL, Obisesan TO, Wolday S, Bwayo SK, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, Kittur S, Borrie M, Lee TY, Bartha R, Johnson S, Asthana S, Carlsson CM, Potkin SG, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre DW, Kataki M, Zimmerman EA, Celmins D, Brown AD, Pearlson GD, Blank K, Anderson K, Santulli RB, Schwartz ES, Sink KM, Williamson JD, Garg P, Watkins F, Ott BR, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen HJ, Miller BL, Mintzer J, Longmire CF, Spicer K, Finger E, Rachinsky I, Drost D, Jernigan T, McCabe C, Grant E, Ernst T, Kuperman J, Chung Y, Murray S, Bloss C, Darst B, Pritchett L, Saito A, Amaral D, DiNino M, Eyngorina B, Sowell E, Houston S, Soderberg L, Kaufmann W, van Zijl P, Rizzo-Busack H, Javid M, Mehta N, Ruberry E, Powers A, Rosen B, Gebhard N, Manigan H, Frazier J, Kennedy D, Yakutis L, Hill M, Gruen J, Bosson-Heenan J, Carlson H. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3985-90. PMID: 22343285; PMCID: PMC3309762.
      35. Kuperman J, Brown TT, Ahmadi ME, Erhart MJ, White NS, Roddey JC, Shankaranarayanan A, Han ET, Rettmann D, Dale AM. Prospective motion correction improves diagnostic utility of pediatric MRI scans. Pediatr Radiol. 2011 Dec; 41(12):1578-82. PMID: 21779892; PMCID: PMC3933373.
      36. Brown TT, Kuperman J, Erhart M, White NS, Roddey JC, Shankaranarayanan A, Han ET, Rettmann D, Dale AM. Prospective motion correction of high-resolution magnetic resonance imaging data in children. Neuroimage. 2010 Oct 15; 53(1):139-45. PMID: 20542120; PMCID: PMC3146240.
      37. Rizk-Jackson A, Stoffers D, Sheldon S, Kuperman J, Dale A, Goldstein J, Corey-Bloom J, Poldrack RA, Aron AR. Evaluating imaging biomarkers for neurodegeneration in pre-symptomatic Huntington's disease using machine learning techniques. Neuroimage. 2011 May 15; 56(2):788-96. PMID: 20451620.
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      38. White N, Roddey C, Shankaranarayanan A, Han E, Rettmann D, Santos J, Kuperman J, Dale A. PROMO: Real-time prospective motion correction in MRI using image-based tracking. Magn Reson Med. 2010 Jan; 63(1):91-105. PMID: 20027635; PMCID: PMC2892665.
      39. Holland D, Kuperman J, Dale AM. Efficient correction of inhomogeneous static magnetic field-induced distortion in Echo Planar Imaging. Neuroimage. 2010 Mar; 50(1):175-83. PMID: 19944768; PMCID: PMC2819607.
      40. Perry ME, McDonald CR, Hagler DJ, Gharapetian L, Kuperman J, Koyama AK, Dale AM, McEvoy LK. White matter tracts associated with set-shifting in healthy aging. Neuropsychologia. 2009 Nov; 47(13):2835-42. PMID: 19540862; PMCID: PMC2749901.
      41. Hagler DJ, Ahmadi ME, Kuperman J, Holland D, McDonald CR, Halgren E, Dale AM. Automated white-matter tractography using a probabilistic diffusion tensor atlas: Application to temporal lobe epilepsy. Hum Brain Mapp. 2009 May; 30(5):1535-47. PMID: 18671230; PMCID: PMC2754725.
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