Dr. Aladdin H. Shadyab is an Assistant Professor of Epidemiology in the Herbert Wertheim School of Public Health and Human Longevity Science at the University of California, San Diego. Dr. Shadyab’s research focuses on the epidemiology of aging. His research interests include: aging biomarkers, geroscience, leveraging multi-omics data (e.g., epigenomics) to understand the role of biological aging in the etiology of chronic diseases of aging, identifying determinants of longevity and healthy aging, and conducting observational and intervention studies in Alzheimer's disease and related dementias.
Dr. Shadyab's robust research program is funded by the National Institute on Aging (NIA). He is Principal Investigator on an NIA-funded R01 (RF1AG074345) to identify epigenetic biomarkers of biological aging for mild cognitive impairment, Alzheimer's disease and related dementias, cognitively healthy longevity, and brain aging. In addition, Dr. Shadyab has served as a long-term investigator of the Women's Health Initiative, the largest longitudinal cohort study of women's health ever conducted in the country. Dr. Shadyab has expertise in the recruitment of patients with mild cognitive impairment or Alzheimer's disease into pharmacologic and lifestyle intervention clinical trials, including both industry-sponsored and NIH-funded trials, and has published papers on the most effective approaches for recruitment of patients across the spectrum of Alzheimer's disease into clinical trials.
Dr. Shadyab has authored more than 150 scientific publications in prestigious, high-impact journals, including Alzheimer's & Dementia, Neurology, JAMA, Annals of Internal Medicine, American Journal of Public Health, and American Journal of Epidemiology. He mentors and trains doctoral students and post-doctoral fellows in the epidemiology of aging. Dr. Shadyab is a member of the Gerontological Society of America and serves in several local and national leadership positions, including Chair of the Women's Health Initiative COVID-19 Scientific Interest Group.