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Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage. PLoS One. 2018; 13(9):e0198464.
Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG. PMID: 30248101.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Nerve-targeted probes for fluorescence-guided intraoperative imaging. Theranostics. 2018; 8(15):4226-4237.
Hingorani DV, Whitney MA, Friedman B, Kwon JK, Crisp JL, Xiong Q, Gross L, Kane CJ, Tsien RY, Nguyen QT. PMID: 30128049.
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PubMed Mentions:
13 Fields:
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HumansAnimalsCells
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Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today (Kidlington). 2018 Nov; 21(9):951-959.
Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. PMID: 31156331.
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Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent. Arthritis Rheumatol. 2018 01; 70(1):69-79.
Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. PMID: 29164814.
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Animals
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Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncol. 2017 08; 71:156-162.
Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT. PMID: 28688684.
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PubMed Mentions:
2 Fields:
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Animals
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Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12774-12779.
Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY. PMID: 27791138.
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PubMed Mentions:
6 Fields:
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Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nat Commun. 2016 10 04; 7:13019.
Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. PMID: 27698471.
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PubMed Mentions:
17 Fields:
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HumansAnimalsCells
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Improved facial nerve identification during parotidectomy with fluorescently labeled peptide. Laryngoscope. 2016 12; 126(12):2711-2717.
Hussain T, Nguyen LT, Whitney M, Hasselmann J, Nguyen QT. PMID: 27171862.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. PLoS One. 2015; 10(10):e0139833.
Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA. PMID: 26448434.
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PubMed Mentions:
8 Fields:
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Animals
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Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome. PLoS One. 2015; 10(3):e0119600.
Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT. PMID: 25751149.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncol. 2015 May; 51(5):470-5.
Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT. PMID: 25735654.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngol Head Neck Surg. 2014 Oct; 151(4):612-8.
Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen QT. PMID: 25091190.
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PubMed Mentions:
14 Fields:
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HumansAnimalsCells
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An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS One. 2014; 9(5):e97415.
Levin RA, Felsen CN, Yang J, Lin JY, Whitney MA, Nguyen QT, Tsien RY. PMID: 24816650.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. . 2014 Jun; 13(6):1514-25.
Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY. PMID: 24737028.
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Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb; 75(2):303-8.
Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. PMID: 24740641.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. . 2014 Apr 15; 306(8):L764-74.
Felsen CN, Savariar EN, Whitney M, Tsien RY. PMID: 24508733.
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Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):325-30.
Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen QT, Tsien RY. PMID: 23080482.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci. 2012 May 30; 32(22):7622-31.
Chen B, Friedman B, Whitney MA, Winkle JA, Lei IF, Olson ES, Cheng Q, Pereira B, Zhao L, Tsien RY, Lyden PD. PMID: 22649241.
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PubMed Mentions:
43 Fields:
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Animals
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In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr Biol (Camb). 2012 Jun; 4(6):595-605.
Olson ES, Whitney MA, Friedman B, Aguilera TA, Crisp JL, Baik FM, Jiang T, Baird SM, Tsimikas S, Tsien RY, Nguyen QT. PMID: 22534729.
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PubMed Mentions:
25 Fields:
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HumansAnimalsCells
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Improved facial nerve identification with novel fluorescently labeled probe. Laryngoscope. 2011 Apr; 121(4):805-10.
Wu AP, Whitney MA, Crisp JL, Friedman B, Tsien RY, Nguyen QT. PMID: 21328585.
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PubMed Mentions:
20 Fields:
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AnimalsCells
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Fluorescent peptides highlight peripheral nerves during surgery in mice. Nat Biotechnol. 2011 Apr; 29(4):352-6.
Whitney MA, Crisp JL, Nguyen LT, Friedman B, Gross LA, Steinbach P, Tsien RY, Nguyen QT. PMID: 21297616.
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PubMed Mentions:
77 Fields:
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HumansAnimalsCells
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Diverse small-molecule modulators of SMN expression found by high-throughput compound screening: early leads towards a therapeutic for spinal muscular atrophy. Hum Mol Genet. 2005 Jul 15; 14(14):2003-18.
Jarecki J, Chen X, Bernardino A, Coovert DD, Whitney M, Burghes A, Stack J, Pollok BA. PMID: 15944201.
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PubMed Mentions:
61 Fields:
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HumansCells
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Gain-of-function somatic cell lines for drug discovery applications generated by homologous recombination. Assay Drug Dev Technol. 2003 Dec; 1(6):755-65.
Zeh K, Sanders P, Londo P, Crute JJ, Pollok BA, Whitney MA. PMID: 15090222.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells