Julie Law

Title(s)	Associate Adjunct Professor, Cell and Developmental Biology
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Establishment and Modulation of DNA Methylation Patterns in Arabidopsis
NIH R01GM112966Feb 15, 2015 - Jul 31, 2025
Role: Principal Investigator

Genetic Analysis of RNA-directed DNA Methylation
NIH F32GM082045Sep 1, 2007 - Aug 31, 2010
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation. Curr Opin Genet Dev. 2024 Feb; 84:102147. Xu G, Law JA. PMID: 38176333; PMCID: PMC10922829.

View in: PubMed Mentions: Fields:
Gen Genetics
Translation:Cells
CLSY docking to Pol IV requires a conserved domain critical for small RNA biogenesis and transposon silencing. bioRxiv. 2023 Dec 26. Felgines L, Rymen B, Martins LM, Xu G, Matteoli C, Himber C, Zhou M, Eis J, Coruh C, Böhrer M, Kuhn L, Chicher J, Pandey V, Hammann P, Wohlschlegel J, Waltz F, Law JA, Blevins T. PMID: 38234754; PMCID: PMC10793415.

View in: PubMed Mentions:
Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change. bioRxiv. 2023 Dec 13. Dehkordi SR, Wong IT, Ni J, Luebeck J, Zhu K, Prasad G, Krockenberger L, Xu G, Chowdhury B, Rajkumar U, Caplin A, Muliaditan D, Coruh C, Jin Q, Turner K, Teo SX, Pang AWC, Alexandrov LB, Chua CEL, Furnari FB, Paulson TG, Law JA, Chang HY, Yue F, DasGupta R, Zhao J, Mischel PS, Bafna V. PMID: 38168210; PMCID: PMC10760206.

View in: PubMed Mentions:
Moving targets: Mechanisms regulating siRNA production and DNA methylation during plant development. Curr Opin Plant Biol. 2023 10; 75:102435. Martins LM, Law JA. PMID: 37598540; PMCID: PMC10581331.

View in: PubMed Mentions: 1 Fields:
Bot Botany
Translation:Cells
Therapy for insomnia with chronic obstructive pulmonary disease: a randomized trial of components. J Clin Sleep Med. 2022 12 01; 18(12):2763-2774. Kapella M, Steffen A, Prasad B, Laghi F, Vispute S, Kemner G, Teixeira C, Peters T, Jun J, Law J, Carley D. PMID: 35946416; PMCID: PMC9713922.

View in: PubMed Mentions: 3 Fields:
Neu Neurology Psy Psychophysiology
Translation:Humans
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. Nat Genet. 2022 11; 54(11):1746-1754. Hung KL, Luebeck J, Dehkordi SR, Colón CI, Li R, Wong IT, Coruh C, Dharanipragada P, Lomeli SH, Weiser NE, Moriceau G, Zhang X, Bailey C, Houlahan KE, Yang W, González RC, Swanton C, Curtis C, Jamal-Hanjani M, Henssen AG, Law JA, Greenleaf WJ, Lo RS, Mischel PS, Bafna V, Chang HY. PMID: 36253572; PMCID: PMC9649439.

View in: PubMed Mentions: 23 Fields:
Gen Genetics
Translation:Humans
Chemoenzymatic labeling of DNA methylation patterns for single-molecule epigenetic mapping. Nucleic Acids Res. 2022 09 09; 50(16):e92. Gabrieli T, Michaeli Y, Avraham S, Torchinsky D, Margalit S, Schütz L, Juhasz M, Coruh C, Arbib N, Zhou ZS, Law JA, Weinhold E, Ebenstein Y. PMID: 35657088; PMCID: PMC9458417.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis. Nat Commun. 2022 01 11; 13(1):244. Zhou M, Coruh C, Xu G, Martins LM, Bourbousse C, Lambolez A, Law JA. PMID: 35017514; PMCID: PMC8752594.

View in: PubMed Mentions: 23 Fields:
Bio Biology Sci Science
Translation:Animals Cells
AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications. Nat Commun. 2020 09 01; 11(1):4374. Luebeck J, Coruh C, Dehkordi SR, Lange JT, Turner KM, Deshpande V, Pai DA, Zhang C, Rajkumar U, Law JA, Mischel PS, Bafna V. PMID: 32873787; PMCID: PMC7463033.

View in: PubMed Mentions: 36 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 11; 575(7784):699-703. Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. PMID: 31748743; PMCID: PMC7094777.

View in: PubMed Mentions: 196 Fields:
Sci Science
Translation:Humans Cells
Directions for research and training in plant omics: Big Questions and Big Data. Plant Direct. 2019 Apr; 3(4):e00133. Argueso CT, Assmann SM, Birnbaum KD, Chen S, Dinneny JR, Doherty CJ, Eveland AL, Friesner J, Greenlee VR, Law JA, Marshall-Colón A, Mason GA, O'Lexy R, Peck SC, Schmitz RJ, Song L, Stern D, Varagona MJ, Walley JW, Williams CM. PMID: 31245771; PMCID: PMC6589541.

View in: PubMed Mentions: 10
SOG1 activator and MYB3R repressors regulate a complex DNA damage network in Arabidopsis. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12453-E12462. Bourbousse C, Vegesna N, Law JA. PMID: 30541889; PMCID: PMC6310815.

View in: PubMed Mentions: 57 Fields:
Sci Science
Translation:Animals Cells
Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family. Nat Genet. 2018 06; 50(6):865-873. Zhou M, Palanca AMS, Law JA. PMID: 29736015; PMCID: PMC6317521.

View in: PubMed Mentions: 58 Fields:
Gen Genetics
Translation:Animals Cells
The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. Elife. 2017 04 28; 6. Li D, Palanca AMS, Won SY, Gao L, Feng Y, Vashisht AA, Liu L, Zhao Y, Liu X, Wu X, Li S, Le B, Kim YJ, Yang G, Li S, Liu J, Wohlschlegel JA, Guo H, Mo B, Chen X, Law JA. PMID: 28452714; PMCID: PMC5462541.

View in: PubMed Mentions: 5 Fields:
Bio Biology
Translation:Animals Cells
RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules. Curr Opin Plant Biol. 2015 Oct; 27:154-64. Zhou M, Law JA. PMID: 26344361; PMCID: PMC4618083.

View in: PubMed Mentions: 42 Fields:
Bot Botany
Translation:Animals Cells
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 2013 Jun 20; 498(7454):385-9. Law JA, Du J, Hale CJ, Feng S, Krajewski K, Palanca AM, Strahl BD, Patel DJ, Jacobsen SE. PMID: 23636332; PMCID: PMC4119789.

View in: PubMed Mentions: 175 Fields:
Sci Science
Translation:Animals Cells
DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. Nat Struct Mol Biol. 2012 Sep; 19(9):870-5. Zhong X, Hale CJ, Law JA, Johnson LM, Feng S, Tu A, Jacobsen SE. PMID: 22864289; PMCID: PMC3443314.

View in: PubMed Mentions: 107 Fields:
Mol Molecular Biology
Translation:Animals Cells
Cognitive behavioral therapy for insomnia comorbid with COPD is feasible with preliminary evidence of positive sleep and fatigue effects. Int J Chron Obstruct Pulmon Dis. 2011; 6:625-35. Kapella MC, Herdegen JJ, Perlis ML, Shaver JL, Larson JL, Law JA, Carley DW. PMID: 22162648; PMCID: PMC3232169.

View in: PubMed Mentions: 31 Fields:
Pul Pulmonary Medicine
Translation:Humans
SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. PLoS Genet. 2011 Jul; 7(7):e1002195. Law JA, Vashisht AA, Wohlschlegel JA, Jacobsen SE. PMID: 21811420; PMCID: PMC3141008.

View in: PubMed Mentions: 105 Fields:
Gen Genetics
Translation:Animals Cells
Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics. 2011 Mar; 6(3):344-54. Greenberg MV, Ausin I, Chan SW, Cokus SJ, Cuperus JT, Feng S, Law JA, Chu C, Pellegrini M, Carrington JC, Jacobsen SE. PMID: 21150311; PMCID: PMC3092683.

View in: PubMed Mentions: 44 Fields:
Gen Genetics
Translation:Animals Cells
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev. 2011 Jan 15; 25(2):137-52. Rajakumara E, Law JA, Simanshu DK, Voigt P, Johnson LM, Reinberg D, Patel DJ, Jacobsen SE. PMID: 21245167; PMCID: PMC3022260.

View in: PubMed Mentions: 63 Fields:
Mol Molecular Biology
Translation:Animals Cells
SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18557-62. Guo L, Yu Y, Law JA, Zhang X. PMID: 20937886; PMCID: PMC2972934.

View in: PubMed Mentions: 61 Fields:
Sci Science
Translation:Animals Cells
A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol. 2010 May 25; 20(10):951-6. Law JA, Ausin I, Johnson LM, Vashisht AA, Zhu JK, Wohlschlegel JA, Jacobsen SE. PMID: 20409711; PMCID: PMC2972704.

View in: PubMed Mentions: 114 Fields:
Bio Biology
Translation:Animals Cells
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet. 2010 Mar; 11(3):204-20. Law JA, Jacobsen SE. PMID: 20142834; PMCID: PMC3034103.

View in: PubMed Mentions: 1584 Fields:
Gen Genetics
Translation:Animals Cells
Molecular biology. Dynamic DNA methylation. Science. 2009 Mar 20; 323(5921):1568-9. Law JA, Jacobsen SE. PMID: 19299607.

View in: PubMed Mentions: 16 Fields:
Sci Science
Translation:Animals Cells
SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet. 2008 Nov; 4(11):e1000280. Johnson LM, Law JA, Khattar A, Henderson IR, Jacobsen SE. PMID: 19043555; PMCID: PMC2582956.

View in: PubMed Mentions: 83 Fields:
Gen Genetics
Translation:Animals Cells
Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion. RNA. 2008 Jun; 14(6):1187-200. Law JA, O'Hearn SF, Sollner-Webb B. PMID: 18441050; PMCID: PMC2390806.

View in: PubMed Mentions: 17 Fields:
Mol Molecular Biology
Translation:Animals Cells
In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. Mol Cell Biol. 2007 Jan; 27(2):777-87. Law JA, O'Hearn S, Sollner-Webb B. PMID: 17101787; PMCID: PMC1800803.

View in: PubMed Mentions: 17 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
T. brucei RNA editing: action of the U-insertional TUTase within a U-deletion cycle. RNA. 2006 Mar; 12(3):476-87. Zhelonkina AG, O'Hearn SF, Law JA, Cruz-Reyes J, Huang CE, Alatortsev VS, Sollner-Webb B. PMID: 16495238; PMCID: PMC1383585.

View in: PubMed Mentions: 6 Fields:
Mol Molecular Biology
Translation:Animals Cells
In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle. Mol Cell Biol. 2005 Apr; 25(7):2785-94. Law JA, Huang CE, O'Hearn SF, Sollner-Webb B. PMID: 15767682; PMCID: PMC1061641.

View in: PubMed Mentions: 15 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells