Jared Young

Title(s)Professor In Residence, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. Young received his BSc. (Hons) in Psychology with Biology and his Ph.D. in Psychopharmacology in the Department of Neuroscience, at the University of Edinburgh, sponsored by the Fujisawa Institute for Neuroscience in Edinburgh. He worked for a year at Organon Laboratories in Scotland prior to his arrival at UCSD to conduct his Post-Doctoral training in 2006. This training was primarily with Profs. Mark Geyer and Dilip Jeste at the Consortium for Translational Research in Neuropsychopharmacology (www.ctrin.org), MIRECC San Diego VA (http://www.mirecc.va.gov/visn22), and the Stein Institute for Research on Aging (www.sira.ucsd.edu) respectively. Dr. Young became a Faculty member in 2009.

    Research Interests

    Dr. Young investigates the molecular biology and neural circuitry underlying behavioral abnormalities occurring in major neuropsychiatric disorders. Debilitating forms of mental illness are prevalent but treatment options for these disorders remain limited. For example, despite the fact that cognitive deficits are a major determinant of impaired function in these patients, there are no approved treatments. Despite molecular and genetic advances, treatment development has not kept pace. One major roadblock for treatment development has been the scarcity of effective cross-species models. Dr. Young uses cutting-edge neuroscience to develop novel and sophisticated cross-species models to identify targetable mechanisms to treat mental illnesses.

    Clinical Focus

    In order to examine the molecular biology and neural circuitry underlying behavioral abnormalities occurring in major neuropsychiatric disorders, we characterize such abnormalities using reverse-translated paradigms. For example, using the human 5-choice continuous performance task (originally developed for mice), we have characterized EEG and fMRI abnormalities that occur in patients with bipolar disorder and schizophrenia, the impact smoking, and smoking cessation, has on attentive properties. By identifying neural mechanisms in patients and healthy subjects, these mechanisms can then be investigated in greater depth using the corresponding animal models.

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    Immunometabolicgene expression profiles associated with depressed mood and behavioral domains inpeople with HIV
    NIH R01MH128869Sep 15, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Translational Studies of Cannabis Administration, Cognition, and the Endocannabinoid System in HIV
    NIH R01DA051295May 1, 2021 - Jan 31, 2026
    Role: Co-Principal Investigator
    Promoting Diversity, Inclusion, and Professional Development in the International Behavioral Neuroscience Society
    NIH R13MH126604Apr 20, 2021 - Mar 31, 2023
    Role: Principal Investigator
    Cannabis use and the endocannabinoid system in bipolar disorder
    NIH R01DA043535May 1, 2018 - Feb 28, 2023
    Role: Co-Principal Investigator
    Cross-species studies of smoking effects on cognition and neuroinflammation in HIV
    NIH R01DA044909Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Neurophysiological biomarkers of behavioral dimensions from cross-species paradigms
    NIH UH3MH109168Apr 1, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Neurophysiological biomarkers of behavioral dimensions from cross-species paradigms
    NIH UH2MH109168Apr 1, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Oxytocin as a therapeutic target for Schizophrenia
    NIH R01MH103421Apr 1, 2015 - Mar 31, 2021
    Role: Principal Investigator
    A model organism of brain circuitry and behavioral switching for bipolar disorder
    NIH R01MH104344Jul 1, 2014 - May 31, 2019
    Role: Principal Investigator
    Alpha 7 nicotinic receptor-mediated enhancement of reinforcement learning
    NIH R21MH101579Apr 1, 2014 - Mar 31, 2017
    Role: Principal Investigator
    Visuospatial priming in rats: A novel animal model for Tourette Syndrome
    NIH R21MH091571Jul 21, 2010 - Apr 30, 2013
    Role: Principal Investigator
    The rodent continuous performance task: Filling the vigilance translational gap
    NIH R21MH085221Jul 7, 2009 - Jun 30, 2012
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Decision-making for delaying punishment? A commentary to Minnes et al. (2024). Cogn Affect Behav Neurosci. 2024 Mar 08. Young JW, Roberts BZ. PMID: 38459405.
      View in: PubMed   Mentions:    Fields:    
    2. Sex differences in risk-based decision-making and the modulation of risk preference by dopamine-2 like receptors in rats. Neuropharmacology. 2024 Feb 05; 109851. Ayoub SM, Libster AM, Barnes SA, Dulawa SC, Young JW. PMID: 38325772.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Amphetamine increases motivation of humans and mice as measured by breakpoint, but does not affect an Electroencephalographic biomarker. Cogn Affect Behav Neurosci. 2024 Jan 02. Noback M, Bhakta SG, Talledo JA, Kotz JE, Benster L, Roberts BZ, Nungaray JA, Light GA, Swerdlow NR, Brigman JL, Cavanagh JF, Young JW. PMID: 38168850.
      View in: PubMed   Mentions:    Fields:    
    4. 30 years of the International Behavioral Neuroscience Society: Perspectives on progress from Past Presidents. Neurosci Biobehav Rev. 2023 Dec; 155:105457. Young JW. PMID: 37925092.
      View in: PubMed   Mentions:    Fields:    
    5. Daily mood and cognitive performance of women with and without bipolar disorder: role of menopausal status. Arch Womens Ment Health. 2023 12; 26(6):863-868. Liu Y, Ng HX, Klaus F, Young JW, Eyler LT. PMID: 37667089; PMCID: PMC10632205.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The Role of Cannabis and The Endocannabinoid System in Sleep Regulation and Cognition: A Review of Human and Animal Studies. Behav Sleep Med. 2024 Mar 03; 22(2):217-233. Miranda A, Peek E, Ancoli-Israel S, Young JW, Perry W, Minassian A. PMID: 37401160; PMCID: PMC10761597.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Impaired cognitive control after moderate prenatal alcohol exposure corresponds to altered EEG power during a rodent touchscreen continuous performance task. Neuropharmacology. 2023 Sep 15; 236:109599. Olguin SL, Cavanagh JF, Young JW, Brigman JL. PMID: 37217074; PMCID: PMC10330662.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    8. CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Transl Psychiatry. 2023 05 12; 13(1):167. Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA. PMID: 37173343; PMCID: PMC10182097.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    9. Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making. Cereb Cortex. 2023 05 09; 33(10):5783-5796. Barnes SA, Dillon DG, Young JW, Thomas ML, Faget L, Yoo JH, Der-Avakian A, Hnasko TS, Geyer MA, Ramanathan DS. PMID: 36472411; PMCID: PMC10183731.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Perspective on equitable translational studies and clinical support for an unbiased inclusion of the LGBTQIA2S+community. Neuropsychopharmacology. 2023 05; 48(6):852-856. Goetz TG, Aghi K, Anacker C, Ehrensaft D, Eshel N, Marrocco J, Young JW, Roepke TA. PMID: 36928352; PMCID: PMC10156811.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Development of cross-species translational paradigms for psychiatric research in the Research Domain Criteria era. Neurosci Biobehav Rev. 2023 05; 148:105119. Young JW. PMID: 36889561.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. Short-active gestational photoperiod reduces effortful choice behavior in mice, partial normalization by d-amphetamine. Psychopharmacology (Berl). 2023 Nov; 240(11):2303-2315. Roberts BZ, O'Connor MA, Kenton JA, Barnes SA, Young JW. PMID: 36806900.
      View in: PubMed   Mentions:    Fields:    
    13. A Pilot Assessment of the Effects of HIV and Methamphetamine Dependence on Socially Dysregulated Behavior in the Human Behavioral Pattern Monitor. AIDS Behav. 2023 Aug; 27(8):2617-2628. Miranda A, Perry W, Umlauf A, Young JW, Morgan EE, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC). PMID: 36738342; PMCID: PMC9898694.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Reinforcement learning deficits exhibited by postnatal PCP-treated rats enable deep neural network classification. Neuropsychopharmacology. 2023 08; 48(9):1377-1385. Tranter MM, Aggarwal S, Young JW, Dillon DG, Barnes SA. PMID: 36509858; PMCID: PMC10354061.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression. Pharmacol Biochem Behav. 2023 01; 222:173499. Ayoub S, Kenton JA, Milienne-Petiot M, Deben DS, Achim C, Geyer MA, Perry W, Grant IE, Young JW, Minassian A, TMARC. PMID: 36462584; PMCID: PMC10014034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    16. Translational cognitive systems: focus on attention. Emerg Top Life Sci. 2022 Nov 21. Roberts BZ, Young JW. PMID: 36408755.
      View in: PubMed   Mentions: 4     Fields:    
    17. The interplay of daily affect and impulsivity measured by mobile surveys in bipolar disorder. Int J Bipolar Disord. 2022 Oct 31; 10(1):25. Titone MK, Depp C, Klaus F, Carrasco J, Young JW, Eyler LT. PMID: 36310294; PMCID: PMC9618470.
      View in: PubMed   Mentions:
    18. Chronic methamphetamine exposure exerts few effects on the iTat mouse model of HIV, but blocks Tat expression-induced slowed reward retrieval. Behav Brain Res. 2023 02 02; 437:114109. Young JW, Kenton JA, Milienne-Petiot M, Deben D, Achim C, Geyer MA, Perry W, Grant IE, Minassian A, TMARC. PMID: 36108778; PMCID: PMC10878174.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    19. The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor. Psychiatry Res. 2022 10; 316:114776. Minassian A, Kelsoe JR, Miranda A, Young JW, Perry W. PMID: 35964417; PMCID: PMC9885942.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. The 2020 International Behavioral Neuroscience Society (IBNS) meeting - Troubles & progress. Neurosci Biobehav Rev. 2022 Dec; 143:104819. Young JW, Byrnes EM. PMID: 35940308; PMCID: PMC9354388.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Correction to: Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms. Transl Psychiatry. 2022 Jul 21; 12(1):290. Cavanagh JF, Gregg D, Light GA, Olguin SL, Sharp RF, Bismark AW, Bhakta SG, Swerdlow NR, Brigman JL, Young JW. PMID: 35864090; PMCID: PMC9304120.
      View in: PubMed   Mentions:    Fields:    
    22. Combined prior chronic methamphetamine treatment and gp120 expression reduce PPI in aged male but not female mice. Neurosci Lett. 2022 05 29; 780:136639. Jordan Walter T, Minassian A, Perry W, Young JW, Translational Methamphetamine AIDS Research Center (TMARC). PMID: 35452766.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    23. Amphetamine alters an EEG marker of reward processing in humans and mice. Psychopharmacology (Berl). 2022 Mar; 239(3):923-933. Cavanagh JF, Olguin SL, Talledo JA, Kotz JE, Roberts BZ, Nungaray JA, Sprock J, Gregg D, Bhakta SG, Light GA, Swerdlow NR, Young JW, Brigman JL. PMID: 35132440; PMCID: PMC8891070.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    24. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Res Neuroimaging. 2022 04; 321:111445. Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. PMID: 35101828.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    25. EEG reveals that dextroamphetamine improves cognitive control through multiple processes in healthy participants. Neuropsychopharmacology. 2022 04; 47(5):1029-1036. Bhakta SG, Cavanagh JF, Talledo JA, Kotz JE, Benster L, Roberts BZ, Nungaray JA, Brigman JL, Light GA, Swerdlow NR, Young JW. PMID: 35042948; PMCID: PMC8938448.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Preclinical Evaluation of Attention and Impulsivity Relevant to Determining ADHD Mechanisms and Treatments. Curr Top Behav Neurosci. 2022; 57:291-320. Kenton JA, Young JW. PMID: 35606639.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    27. HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits. Int J Neuropsychopharmacol. 2021 11 12; 24(11):894-906. Roberts BZ, Minassian A, Halberstadt AL, He YV, Chatha M, Geyer MA, Grant I, Young JW. PMID: 34338765; PMCID: PMC8598295.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    28. Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms. Transl Psychiatry. 2021 09 17; 11(1):482. Cavanagh JF, Gregg D, Light GA, Olguin SL, Sharp RF, Bismark AW, Bhakta SG, Swerdlow NR, Brigman JL, Young JW. PMID: 34535625; PMCID: PMC8448772.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    29. HIV Transgenic Rats Demonstrate Superior Task Acquisition and Intact Reversal Learning in the Within-Session Probabilistic Reversal Learning Task. Cogn Affect Behav Neurosci. 2021 12; 21(6):1207-1221. Roberts BZ, He YV, Chatha M, Minassian A, Grant I, Young JW. PMID: 34312815.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    30. The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review. Arch Clin Neuropsychol. 2021 Jul 19; 36(5):673-685. Pocuca N, Walter TJ, Minassian A, Young JW, Geyer MA, Perry W. PMID: 33159510; PMCID: PMC8296849.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    31. The Relationships between HIV-1 Infection, History of Methamphetamine Use Disorder, and Soluble Biomarkers in Blood and Cerebrospinal Fluid. Viruses. 2021 07 01; 13(7). Walter TJ, Iudicello J, Cookson DR, Franklin D, Tang B, Young JW, Perry W, Ellis R, Heaton RK, Grant I, Minassian A, Letendre S. PMID: 34372493; PMCID: PMC8310127.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    32. Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice. Behav Brain Res. 2021 05 07; 405:113167. Cope ZA, Kenton JA, Minassian A, Martin MV, Perry W, Bundgaard C, Arnt J, van Enkhuizen J, Geyer MA, Young JW. PMID: 33577882; PMCID: PMC10729608.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    33. Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a D1 but not nicotinic agonist. Psychopharmacology (Berl). 2021 Apr; 238(4):979-990. Grottick AJ, MacQueen DL, Barnes SA, Carroll C, Sanabria EK, Bobba V, Young JW. PMID: 33404734.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. The relationship between cannabis use and cognition in people with bipolar disorder: A systematic scoping review. Psychiatry Res. 2021 03; 297:113695. Jordan Walter T, Pocuca N, Young JW, Geyer MA, Minassian A, Perry W. PMID: 33545431; PMCID: PMC7914198.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus. Cogn Affect Behav Neurosci. 2020 12; 20(6):1173-1183. Cope ZA, Lavadia ML, Joosen AJM, van de Cappelle CJA, Lara JC, Huval A, Kwiatkowski MK, Picciotto MR, Mineur YS, Dulcis D, Young JW. PMID: 32794101; PMCID: PMC7718303.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    36. Chronic nicotine, but not suramin or resveratrol, partially remediates the mania-like profile of dopamine transporter knockdown mice. Eur Neuropsychopharmacol. 2021 01; 42:75-86. Kwiatkowski MA, Roberts BZ, van Enkhuizen J, Ji B, Zhou X, Young JW. PMID: 33191077; PMCID: PMC8853461.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    37. Both HIV and Tat expression decrease prepulse inhibition with further impairment by methamphetamine. Prog Neuropsychopharmacol Biol Psychiatry. 2021 03 02; 106:110089. Walter TJ, Young JW, Milienne-Petiot M, Deben DS, Heaton RK, Letendre S, Grelotti DJ, Perry W, Grant I, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC). PMID: 32891668; PMCID: PMC7750302.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    38. Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence. Drug Alcohol Depend. 2020 10 01; 215:108245. Pocuca N, Young JW, MacQueen DA, Letendre S, Heaton RK, Geyer MA, Perry W, Grant I, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC). PMID: 32871507; PMCID: PMC7811354.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. Short-active photoperiod gestation induces psychiatry-relevant behavior in healthy mice but a resiliency to such effects are seen in mice with reduced dopamine transporter expression. Sci Rep. 2020 06 23; 10(1):10217. Kwiatkowski MA, Cope ZA, Lavadia ML, van de Cappelle CJA, Dulcis D, Young JW. PMID: 32576854; PMCID: PMC7311429.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    40. Amphetamine improves rat 5-choice continuous performance test (5C-CPT) irrespective of concurrent low-dose haloperidol treatment. Psychopharmacology (Berl). 2020 Jul; 237(7):1959-1972. Young JW, Roberts BZ, Breier M, Swerdlow NR. PMID: 32318751.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    41. Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task. Genes Brain Behav. 2021 01; 20(1):e12652. Olguin SL, Thompson SM, Young JW, Brigman JL. PMID: 32144885; PMCID: PMC8128045.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    42. The D2-family receptor agonist bromocriptine but, not nicotine, reverses NMDA receptor antagonist-induced working memory deficits in the radial arm maze in mice. Neurobiol Learn Mem. 2020 02; 168:107159. MacQueen DA, Young JW. PMID: 31911198.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Transl Psychiatry. 2019 09 09; 9(1):222. Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. PMID: 31501410; PMCID: PMC6733800.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    44. Reconsidering the Latent Structure of Negative Symptoms in Schizophrenia: A Review of Evidence Supporting the 5 Consensus Domains. Schizophr Bull. 2019 06 18; 45(4):725-729. Strauss GP, Ahmed AO, Young JW, Kirkpatrick B. PMID: 30541136; PMCID: PMC6581128.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    45. Current status of the neurobiology of aggression and impulsivity. Neuropharmacology. 2019 09 15; 156:107665. Slattery DA, Young JW. PMID: 31176758.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    46. Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT. Bipolar Disord. 2020 02; 22(1):46-58. Young JW, Geyer MA, Halberstadt AL, van Enkhuizen J, Minassian A, Khan A, Perry W, Eyler LT. PMID: 31025493; PMCID: PMC6815232.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    47. Oxytocin improves probabilistic reversal learning but not effortful motivation in Brown Norway rats. Neuropharmacology. 2019 05 15; 150:15-26. Roberts BZ, Young JW, He YV, Cope ZA, Shilling PD, Feifel D. PMID: 30844406; PMCID: PMC6500730.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    48. The importance and depth of reproducibility in rodent models of psychiatric diseases. Pharmacol Biochem Behav. 2019 03; 178:1-2. Young JW, Einat H. PMID: 30777154.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    49. Evidence for light-entrainment-induced switching between depression- & mania-relevant behaviors in mice. Neuropsychopharmacology. 2019 09; 44(10):1679-1680. Young JW, Cope ZA, Romoli B, Schrurs E, Joosen A, van Enkhuizen J, Sharp RF, Dulcis D. PMID: 30787425; PMCID: PMC6784984.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    50. Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning. Eur Neuropsychopharmacol. 2018 11; 28(11):1217-1231. Milienne-Petiot M, Higa KK, Grim A, Deben D, Groenink L, Twamley EW, Geyer MA, Young JW. PMID: 30213668; PMCID: PMC6344043.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    51. Amphetamine improves mouse and human attention in the 5-choice continuous performance test. Neuropharmacology. 2018 08; 138:87-96. MacQueen DA, Minassian A, Kenton JA, Geyer MA, Perry W, Brigman JL, Young JW. PMID: 29859849; PMCID: PMC6340711.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    52. Correction to: The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task. Psychopharmacology (Berl). 2018 05; 235(5):1621. Barnes SA, Young JW, Markou A, Adham N, Gyertyán I, Kiss B. PMID: 29564481; PMCID: PMC6713673.
      View in: PubMed   Mentions: 1     Fields:    
    53. Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia. Transl Psychiatry. 2018 04 12; 8(1):80. Bismark AW, Thomas ML, Tarasenko M, Shiluk AL, Rackelmann SY, Young JW, Light GA. PMID: 29643355; PMCID: PMC5895589.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder. Neuropsychopharmacology. 2018 07; 43(8):1721-1731. Young JW, Cope ZA, Romoli B, Schrurs E, van Enkhuizen J, Sharp RF, Dulcis D. PMID: 29520059; PMCID: PMC6006292.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    55. The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task. Psychopharmacology (Berl). 2018 05; 235(5):1403-1414. Barnes SA, Young JW, Markou A, Adham N, Gyertyán I, Kiss B. PMID: 29473089; PMCID: PMC5920008.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    56. Cross-Species Neurophysiological Biomarkers of Attentional Dysfunction in Schizophrenia: Bridging the Translational Gap. Neuropsychopharmacology. 2018 01; 43(1):230-231. Young JW, Light GA. PMID: 29192660; PMCID: PMC5719116.
      View in: PubMed   Mentions: 2     Fields:    
    57. Cognitive Phenotypes for Biomarker Identification in Mental Illness: Forward and Reverse Translation. Curr Top Behav Neurosci. 2018; 40:111-166. MacQueen DA, Young JW, Cope ZA. PMID: 29858983.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    58. Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors. Pharmacol Biochem Behav. 2019 03; 178:42-50. Kwiatkowski MA, Hellemann G, Sugar CA, Cope ZA, Minassian A, Perry W, Geyer MA, Young JW. PMID: 29289701; PMCID: PMC10014035.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    59. Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors. Int J Neuropsychopharmacol. 2017 12 01; 20(12):979-987. Bhakta SG, Light GA, Talledo JA, Balvaneda B, Hughes E, Alvarez A, Rana BK, Young JW, Swerdlow NR. PMID: 29020372; PMCID: PMC5716101.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    60. Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia. Behav Brain Res. 2019 05 17; 364:413-422. Amitai N, Powell SB, Young JW. PMID: 29175446.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    61. The COMT Val158Met Polymorphism and Exploratory Behavior in Bipolar Mania. Mol Neuropsychiatry. 2018 Feb; 3(3):151-156. Minassian A, Young JW, Geyer MA, Kelsoe JR, Perry W. PMID: 29594134; PMCID: PMC5836247.
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    62. Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol. 2018 04; 24(2):156-167. Thaney VE, Sanchez AB, Fields JA, Minassian A, Young JW, Maung R, Kaul M. PMID: 29075998; PMCID: PMC5911244.
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    63. Amphetamine Modestly Improves Conners' Continuous Performance Test Performance in Healthy Adults. J Int Neuropsychol Soc. 2018 03; 24(3):283-293. MacQueen DA, Minassian A, Henry BL, Geyer MA, Young JW, Perry W. PMID: 29032769; PMCID: PMC5820221.
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    64. Blockade of dopamine D1-family receptors attenuates the mania-like hyperactive, risk-preferring, and high motivation behavioral profile of mice with low dopamine transporter levels. J Psychopharmacol. 2017 10; 31(10):1334-1346. Milienne-Petiot M, Groenink L, Minassian A, Young JW. PMID: 28950781; PMCID: PMC10773978.
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    65. Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species. Neuropharmacology. 2017 Oct; 125:254-262. Cope ZA, Minassian A, Kreitner D, MacQueen DA, Milienne-Petiot M, Geyer MA, Perry W, Young JW. PMID: 28774856; PMCID: PMC6472902.
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    66. The 5 choice continuous performance test (5C-CPT): A novel tool to assess cognitive control across species. J Neurosci Methods. 2017 Dec 01; 292:53-60. Bhakta SG, Young JW. PMID: 28754432; PMCID: PMC5813688.
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    67. Preclinical Models to Investigate Mechanisms of Negative Symptoms in Schizophrenia. Schizophr Bull. 2017 07 01; 43(4):706-711. Barnes SA, Der-Avakian A, Young JW. PMID: 28586462; PMCID: PMC5472160.
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    68. Relationship between effortful motivation and neurocognition in schizophrenia. Schizophr Res. 2018 03; 193:69-76. Bismark AW, Thomas ML, Tarasenko M, Shiluk AL, Rackelmann SY, Young JW, Light GA. PMID: 28673753; PMCID: PMC5754266.
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    69. Introduction to the special issue from the 2015 meeting of the International Behavioral Neuroscience Society. Neurosci Biobehav Rev. 2017 05; 76(Pt B):185-186. Pletnikov M, Young JW, Hall FS, Kent S. PMID: 28300550.
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    70. Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania. Psychopharmacology (Berl). 2017 Mar; 234(6):1017-1028. Milienne-Petiot M, Geyer MA, Arnt J, Young JW. PMID: 28160035; PMCID: PMC5391249.
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    71. Striatal dopamine D1 receptor suppression impairs reward-associative learning. Behav Brain Res. 2017 04 14; 323:100-110. Higa KK, Young JW, Ji B, Nichols DE, Geyer MA, Zhou X. PMID: 28143767.
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    72. The Five-Choice Continuous Performance Task (5C-CPT): A Cross-Species Relevant Paradigm for Assessment of Vigilance and Response Inhibition in Rodents. Curr Protoc Neurosci. 2017 01 03; 78:9.56.1-9.56.18. Cope ZA, Young JW. PMID: 28046200; PMCID: PMC6472906.
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    73. Neurophysiological Characterization of Attentional Performance Dysfunction in Schizophrenia Patients in a Reverse-Translated Task. Neuropsychopharmacology. 2017 May; 42(6):1338-1348. Young JW, Bismark AW, Sun Y, Zhang W, McIlwain M, Grootendorst I, Light GA. PMID: 27917869; PMCID: PMC5437886.
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    74. Adolescent GBR12909 exposure induces oxidative stress, disrupts parvalbumin-positive interneurons, and leads to hyperactivity and impulsivity in adult mice. Neuroscience. 2017 03 14; 345:166-175. Khan A, de Jong LA, Kamenski ME, Higa KK, Lucero JD, Young JW, Behrens MM, Powell SB. PMID: 27890827; PMCID: PMC5316310.
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    75. Research Domain Criteria versus DSM V: How does this debate affect attempts to model corticostriatal dysfunction in animals? Neurosci Biobehav Rev. 2017 05; 76(Pt B):301-316. Young JW, Winstanley CA, Brady AM, Hall FS. PMID: 27826070.
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    76. The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania. Neuropharmacology. 2017 02; 113(Pt A):260-270. Milienne-Petiot M, Kesby JP, Graves M, van Enkhuizen J, Semenova S, Minassian A, Markou A, Geyer MA, Young JW. PMID: 27732870; PMCID: PMC5148687.
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    77. Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges. Psychopharmacology (Berl). 2016 Oct; 233(19-20):3513-25. Cope ZA, Halberstadt AL, van Enkhuizen J, Flynn AD, Breier M, Swerdlow NR, Geyer MA, Young JW. PMID: 27534540; PMCID: PMC5023490.
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    78. Perseveration by NK1R-/- ('knockout') mice is blunted by doses of methylphenidate that affect neither other aspects of their cognitive performance nor the behaviour of wild-type mice in the 5-Choice Continuous Performance Test. J Psychopharmacol. 2016 09; 30(9):837-47. Pillidge K, Porter AJ, Young JW, Stanford SC. PMID: 27097734; PMCID: PMC4994704.
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    79. The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms. Neuropharmacology. 2016 08; 107:262-270. Landgraf D, Joiner WJ, McCarthy MJ, Kiessling S, Barandas R, Young JW, Cermakian N, Welsh DK. PMID: 27033596.
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    80. Effect of 5-HT2A and 5-HT2C receptors on temporal discrimination by mice. Neuropharmacology. 2016 08; 107:364-375. Halberstadt AL, Sindhunata IS, Scheffers K, Flynn AD, Sharp RF, Geyer MA, Young JW. PMID: 27020041; PMCID: PMC5403251.
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    81. Wet or dry: translatable "water mazes" for mice and humans. J Clin Invest. 2016 Feb; 126(2):477-9. Higa KK, Young JW, Geyer MA. PMID: 26784538; PMCID: PMC4731183.
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    82. Locomotor Profiling from Rodents to the Clinic and Back Again. Curr Top Behav Neurosci. 2016; 28:287-303. Young JW, Minassian A, Geyer MA. PMID: 27418071.
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    83. Dispatches from the International Behavioral Neuroscience Society meeting 2014. Introduction. Behav Brain Res. 2015 Dec 15; 295:1-2. Brigman JL, Young JW, Pletnikov M, Kent S. PMID: 26549148.
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    84. Negative visuospatial priming in isolation-reared rats: Evidence of resistance to the disruptive effects of amphetamine. Cogn Affect Behav Neurosci. 2015 Dec; 15(4):901-14. Amitai N, Powell S, Weber M, Swerdlow NR, Young JW. PMID: 26220402; PMCID: PMC4641795.
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    85. Differences in the performance of NK1R-/- ('knockout') and wildtype mice in the 5‑Choice Continuous Performance Test. Behav Brain Res. 2016 Feb 01; 298(Pt B):268-77. Porter AJ, Pillidge K, Stanford SC, Young JW. PMID: 26522842; PMCID: PMC4683099.
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    86. Introduction to the special issue from the 2014 meeting of the International Behavioral Neuroscience Society. Neurosci Biobehav Rev. 2015 Nov; 58:1-3. Young JW, Hall FS, Pletnikov M, Kent S. PMID: 26672720.
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    87. Amphetamine increases activity but not exploration in humans and mice. Psychopharmacology (Berl). 2016 Jan; 233(2):225-33. Minassian A, Young JW, Cope ZA, Henry BL, Geyer MA, Perry W. PMID: 26449721; PMCID: PMC4703551.
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    88. Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies. Neurosci Biobehav Rev. 2015 Nov; 58:4-18. van Enkhuizen J, Geyer MA, Minassian A, Perry W, Henry BL, Young JW. PMID: 26297513; PMCID: PMC4684462.
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    89. Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 2—External Validity and Correlates. Schizophr Bull. 2015 Sep; 41(5):1055-65. Horan WP, Reddy LF, Barch DM, Buchanan RW, Dunayevich E, Gold JM, Marder SR, Wynn JK, Young JW, Green MF. PMID: 26209546; PMCID: PMC4535650.
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    90. Translational Rodent Paradigms to Investigate Neuromechanisms Underlying Behaviors Relevant to Amotivation and Altered Reward Processing in Schizophrenia. Schizophr Bull. 2015 Sep; 41(5):1024-34. Young JW, Markou A. PMID: 26194891; PMCID: PMC4535652.
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    91. Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features. Psychopharmacology (Berl). 2015 Sep; 232(18):3455-67. van Enkhuizen J, Milienne-Petiot M, Geyer MA, Young JW. PMID: 26141192; PMCID: PMC4537820.
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    92. Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 1—Psychometric Characteristics of 5 Paradigms. Schizophr Bull. 2015 Sep; 41(5):1045-54. Reddy LF, Horan WP, Barch DM, Buchanan RW, Dunayevich E, Gold JM, Lyons N, Marder SR, Treadway MT, Wynn JK, Young JW, Green MF. PMID: 26142081; PMCID: PMC4535649.
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    93. Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models. Neurosci Biobehav Rev. 2015 Nov; 58:147-67. Orsini CA, Moorman DE, Young JW, Setlow B, Floresco SB. PMID: 26072028; PMCID: PMC7913606.
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    94. Negative affective states and cognitive impairments in nicotine dependence. Neurosci Biobehav Rev. 2015 Nov; 58:168-85. Hall FS, Der-Avakian A, Gould TJ, Markou A, Shoaib M, Young JW. PMID: 26054790; PMCID: PMC4670824.
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    95. Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice. Int J Neuropsychopharmacol. 2015 Jun 02; 18(11):pyv063. Higa KK, Ji B, Buell MR, Risbrough VB, Powell SB, Young JW, Geyer MA, Zhou X. PMID: 26037489; PMCID: PMC4756721.
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    96. Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats. Dev Neurosci. 2015; 37(3):253-62. Powell SB, Khan A, Young JW, Scott CN, Buell MR, Caldwell S, Tsan E, de Jong LA, Acheson DT, Lucero J, Geyer MA, Behrens MM. PMID: 26022788; PMCID: PMC4644772.
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    97. GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders. Neuropsychopharmacology. 2015 Nov; 40(12):2715-26. Young JW, Kamenski ME, Higa KK, Light GA, Geyer MA, Zhou X. PMID: 25907107; PMCID: PMC4864647.
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    98. Investigating the mechanism(s) underlying switching between states in bipolar disorder. Eur J Pharmacol. 2015 Jul 15; 759:151-62. Young JW, Dulcis D. PMID: 25814263; PMCID: PMC4437855.
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    99. Translational and Early Phase Strategies for Treatment Development: Report of ISCTM Autumn 2013 Symposium. Innov Clin Neurosci. 2015 Mar-Apr; 12(3-4):5S-10S. Young JW, Potter WZ, Riley S, Groeneveld GJ, Kinon BJ, Egan MF, Feltner DE. PMID: 25977839; PMCID: PMC4571292.
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    100. Methamphetamine Exposure Combined with HIV-1 Disease or gp120 Expression: Comparison of Learning and Executive Functions in Humans and Mice. Neuropsychopharmacology. 2015 Jul; 40(8):1899-909. Kesby JP, Heaton RK, Young JW, Umlauf A, Woods SP, Letendre SL, Markou A, Grant I, Semenova S. PMID: 25652249; PMCID: PMC4839513.
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    101. Developing treatments for cognitive deficits in schizophrenia: the challenge of translation. J Psychopharmacol. 2015 Feb; 29(2):178-96. Young JW, Geyer MA. PMID: 25516372; PMCID: PMC4670265.
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    102. The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. Eur J Pharmacol. 2015 Apr 15; 753:114-26. van Enkhuizen J, Janowsky DS, Olivier B, Minassian A, Perry W, Young JW, Geyer MA. PMID: 25107282; PMCID: PMC4318788.
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    103. Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder. Neuropsychopharmacology. 2014 Dec; 39(13):3112-22. van Enkhuizen J, Henry BL, Minassian A, Perry W, Milienne-Petiot M, Higa KK, Geyer MA, Young JW. PMID: 25005251; PMCID: PMC4229584.
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    104. Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet. 2014 Nov 01; 23(21):5683-705. Ji B, Higa KK, Kim M, Zhou L, Young JW, Geyer MA, Zhou X. PMID: 24908665; PMCID: PMC4189903.
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    105. Altered exploration and sensorimotor gating of the chakragati mouse model of schizophrenia. Behav Neurosci. 2014 Aug; 128(4):460-7. Young JW, Ratty A, Dawe GS, Geyer MA. PMID: 24708299; PMCID: PMC4107138.
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    106. Isolation rearing effects on probabilistic learning and cognitive flexibility in rats. Cogn Affect Behav Neurosci. 2014 Mar; 14(1):388-406. Amitai N, Young JW, Higa K, Sharp RF, Geyer MA, Powell SB. PMID: 23943516; PMCID: PMC3923850.
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    107. Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine. Behav Pharmacol. 2014 Feb; 25(1):12-22. Henry BL, Geyer MA, Buell MR, Perry W, Young JW, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 24281153; PMCID: PMC3926694.
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    108. Sleep deprivation impairs performance in the 5-choice continuous performance test: similarities between humans and mice. Behav Brain Res. 2014 Mar 15; 261:40-8. van Enkhuizen J, Acheson D, Risbrough V, Drummond S, Geyer MA, Young JW. PMID: 24333377; PMCID: PMC3937379.
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    109. Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder. J Affect Disord. 2014 Feb; 155:247-54. van Enkhuizen J, Geyer MA, Halberstadt AL, Zhuang X, Young JW. PMID: 24287168; PMCID: PMC3924859.
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    110. Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia. Biochem Pharmacol. 2013 Oct 15; 86(8):1122-32. Young JW, Geyer MA. PMID: 23856289; PMCID: PMC3797190.
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    111. Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development. Front Neurosci. 2013; 7:103. Acheson DT, Twamley EW, Young JW. PMID: 23785309; PMCID: PMC3684768.
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    112. Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia. PLoS One. 2013; 8(6):e66327. Ji B, Wang X, Pinto-Duarte A, Kim M, Caldwell S, Young JW, Behrens MM, Sejnowski TJ, Geyer MA, Zhou X. PMID: 23823008; PMCID: PMC3688895.
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    113. Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor. J Affect Disord. 2013 Sep 25; 150(3):948-54. Henry BL, Minassian A, Patt VM, Hua J, Young JW, Geyer MA, Perry W. PMID: 23759280; PMCID: PMC3759601.
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    114. Further evidence for ClockΔ19 mice as a model for bipolar disorder mania using cross-species tests of exploration and sensorimotor gating. Behav Brain Res. 2013 Jul 15; 249:44-54. van Enkhuizen J, Minassian A, Young JW. PMID: 23623885; PMCID: PMC3672322.
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    115. Bridging the bench to bedside gap: validation of a reverse-translated rodent continuous performance test using functional magnetic resonance imaging. Psychiatry Res. 2013 Jun 30; 212(3):183-91. McKenna BS, Young JW, Dawes SE, Asgaard GL, Eyler LT. PMID: 23570915.
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    116. Demand and modality of directed attention modulate "pre-attentive" sensory processes in schizophrenia patients and nonpsychiatric controls. Schizophr Res. 2013 May; 146(1-3):326-35. Rissling AJ, Park SH, Young JW, Rissling MB, Sugar CA, Sprock J, Mathias DJ, Pela M, Sharp RF, Braff DL, Light GA. PMID: 23490760; PMCID: PMC3622836.
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    117. Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats. Behav Brain Res. 2013 Apr 01; 242:47-53. Turner KM, Young JW, McGrath JJ, Eyles DW, Burne TH. PMID: 23275047.
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    118. Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test. Behav Brain Res. 2013 Mar 01; 240:119-33. Young JW, Meves JM, Geyer MA. PMID: 23201359; PMCID: PMC3538919.
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    119. Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice. Int J Neuropsychopharmacol. 2013 Jun; 16(5):1021-31. van Enkhuizen J, Geyer MA, Kooistra K, Young JW. PMID: 23164454; PMCID: PMC3920978.
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    120. Consideration of species differences in developing novel molecules as cognition enhancers. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt B):2181-93. Young JW, Jentsch JD, Bussey TJ, Wallace TL, Hutcheson DM. PMID: 23064177; PMCID: PMC3594426.
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    121. A novel visuospatial priming task for rats with relevance to Tourette syndrome and modulation of dopamine levels. Neurosci Biobehav Rev. 2013 Jul; 37(6):1139-49. Amitai N, Weber M, Swerdlow NR, Sharp RF, Breier MR, Halberstadt AL, Young JW. PMID: 23010529; PMCID: PMC3556379.
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    122. Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania. Psychopharmacology (Berl). 2013 Feb; 225(3):661-74. van Enkhuizen J, Geyer MA, Young JW. PMID: 22945515; PMCID: PMC3537839.
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    123. Behavioral effects of chronic methamphetamine treatment in HIV-1 gp120 transgenic mice. Behav Brain Res. 2013 Jan 01; 236(1):210-220. Henry BL, Geyer MA, Buell M, Perry W, Young JW, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 22960458; PMCID: PMC3482284.
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    124. The 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy: summaries of oral sessions. Schizophr Res. 2012 Oct; 141(1):e1-e24. Abbs B, Achalia RM, Adelufosi AO, Aktener AY, Beveridge NJ, Bhakta SG, Blackman RK, Bora E, Byun MS, Cabanis M, Carrion R, Castellani CA, Chow TJ, Dmitrzak-Weglarz M, Gayer-Anderson C, Gomes FV, Haut K, Hori H, Kantrowitz JT, Kishimoto T, Lee FH, Lin A, Palaniyappan L, Quan M, Rubio MD, Ruiz de Azúa S, Sahoo S, Strauss GP, Szczepankiewicz A, Thompson AD, Trotta A, Tully LM, Uchida H, Velthorst E, Young JW, O'Shea A, Delisi LE. PMID: 22910407; PMCID: PMC3877922.
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    125. Four factors underlying mouse behavior in an open field. Behav Brain Res. 2012 Jul 15; 233(1):55-61. Tanaka S, Young JW, Halberstadt AL, Masten VL, Geyer MA. PMID: 22569582; PMCID: PMC3866095.
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    126. Attentional processing in C57BL/6J mice exposed to developmental vitamin D deficiency. PLoS One. 2012; 7(4):e35896. Harms LR, Turner KM, Eyles DW, Young JW, McGrath JJ, Burne TH. PMID: 22563415; PMCID: PMC3338544.
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    127. Measuring the construct of executive control in schizophrenia: defining and validating translational animal paradigms for discovery research. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt B):2125-40. Gilmour G, Arguello A, Bari A, Brown VJ, Carter C, Floresco SB, Jentsch DJ, Tait DS, Young JW, Robbins TW. PMID: 22548905.
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    128. Hippocampal calbindin-1 immunoreactivity correlate of recognition memory performance in aged mice. Neurosci Lett. 2012 May 10; 516(1):161-5. Soontornniyomkij V, Risbrough VB, Young JW, Soontornniyomkij B, Jeste DV, Achim CL. PMID: 22503902; PMCID: PMC3338865.
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    129. Examining the genetic and neural components of cognitive flexibility using mice. Physiol Behav. 2012 Dec 05; 107(5):666-9. Brigman JL, Powell EM, Mittleman G, Young JW. PMID: 22234243; PMCID: PMC3337351.
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    130. Behavioral animal models to assess pro-cognitive treatments for schizophrenia. Handb Exp Pharmacol. 2012; (213):39-79. Young JW, Amitai N, Geyer MA. PMID: 23027412.
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    131. Predictive animal models of mania: hits, misses and future directions. Br J Pharmacol. 2011 Oct; 164(4):1263-84. Young JW, Henry BL, Geyer MA. PMID: 21410454; PMCID: PMC3229761.
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    132. D₁ receptor activation improves vigilance in rats as measured by the 5-choice continuous performance test. Psychopharmacology (Berl). 2012 Mar; 220(1):129-41. Barnes SA, Young JW, Neill JC. PMID: 21901319; PMCID: PMC5870138.
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    133. Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals. PLoS One. 2011; 6(8):e24185. Minassian A, Henry BL, Young JW, Masten V, Geyer MA, Perry W. PMID: 21912623; PMCID: PMC3166173.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    134. Factor analysis of attentional set-shifting performance in young and aged mice. Behav Brain Funct. 2011 Aug 12; 7:33. Tanaka S, Young JW, Gresack JE, Geyer MA, Risbrough VB. PMID: 21838910; PMCID: PMC3174878.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    135. Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice. Genes Brain Behav. 2011 Oct; 10(7):720-33. Young JW, Meves JM, Tarantino IS, Caldwell S, Geyer MA. PMID: 21679297; PMCID: PMC3918170.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    136. Mouse pharmacological models of cognitive disruption relevant to schizophrenia. Neuropharmacology. 2012 Mar; 62(3):1381-90. Young JW, Powell SB, Geyer MA. PMID: 21726569; PMCID: PMC3217063.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    137. Rats tested after a washout period from sub-chronic PCP administration exhibited impaired performance in the 5-Choice Continuous Performance Test (5C-CPT) when the attentional load was increased. Neuropharmacology. 2012 Mar; 62(3):1432-41. Barnes SA, Young JW, Neill JC. PMID: 21569782; PMCID: PMC5870141.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    138. The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding. Behav Brain Res. 2011 Sep 12; 222(1):183-92. Young JW, Powell SB, Scott CN, Zhou X, Geyer MA. PMID: 21458500; PMCID: PMC3531561.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    139. Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice. Age (Dordr). 2012 Apr; 34(2):305-16. Soontornniyomkij V, Risbrough VB, Young JW, Soontornniyomkij B, Jeste DV, Achim CL. PMID: 21431350; PMCID: PMC3312638.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    140. Increased risk-taking behavior in dopamine transporter knockdown mice: further support for a mouse model of mania. J Psychopharmacol. 2011 Jul; 25(7):934-43. Young JW, van Enkhuizen J, Winstanley CA, Geyer MA. PMID: 21421642; PMCID: PMC3568506.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    141. Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil. Neuropsychopharmacology. 2011 Jun; 36(7):1385-96. Young JW, Kooistra K, Geyer MA. PMID: 21412225; PMCID: PMC3096808.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    142. Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm. Psychopharmacology (Berl). 2011 Jun; 215(4):697-707. Henry BL, Minassian A, van Rhenen M, Young JW, Geyer MA, Perry W, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 21279333; PMCID: PMC3102201.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    143. Working memory span capacity improved by a D2 but not D1 receptor family agonist. Behav Brain Res. 2011 Jun 01; 219(2):181-8. Tarantino IS, Sharp RF, Geyer MA, Meves JM, Young JW. PMID: 21232557; PMCID: PMC3073724.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    144. Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice. Brain Res. 2011 Jan 12; 1368:65-70. Ali SS, Young JW, Wallace CK, Gresack J, Jeste DV, Geyer MA, Dugan LL, Risbrough VB. PMID: 21075081; PMCID: PMC3018762.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    145. Evaluation of the clinical efficacy of asenapine in schizophrenia. Expert Opin Pharmacother. 2010 Aug; 11(12):2107-15. Minassian A, Young JW. PMID: 20642375; PMCID: PMC2924192.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    146. Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm. Psychiatry Res. 2010 Jun 30; 178(1):84-91. Perry W, Minassian A, Henry B, Kincaid M, Young JW, Geyer MA. PMID: 20471103; PMCID: PMC2914139.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    147. The mouse attentional-set-shifting task: a method for assaying successful cognitive aging? Cogn Affect Behav Neurosci. 2010 May; 10(2):243-51. Young JW, Powell SB, Geyer MA, Jeste DV, Risbrough VB. PMID: 20498348; PMCID: PMC2877277.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    148. Short-term recognition memory impairment is associated with decreased expression of FK506 binding protein 51 in the aged mouse brain. Age (Dordr). 2010 Sep; 32(3):309-22. Soontornniyomkij V, Risbrough VB, Young JW, Wallace CK, Soontornniyomkij B, Jeste DV, Achim CL. PMID: 20422297; PMCID: PMC2926850.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    149. Cross-species assessments of motor and exploratory behavior related to bipolar disorder. Neurosci Biobehav Rev. 2010 Jul; 34(8):1296-306. Henry BL, Minassian A, Young JW, Paulus MP, Geyer MA, Perry W. PMID: 20398694; PMCID: PMC2900445.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    150. The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration. Pharmacol Biochem Behav. 2010 Jul; 96(1):7-15. Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA. PMID: 20363246; PMCID: PMC2878916.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    151. Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors? Biol Psychiatry. 2010 Apr 15; 67(8):784-7. Young JW, Geyer MA. PMID: 20132929; PMCID: PMC2849918.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    152. Age-associated improvements in cross-modal prepulse inhibition in mice. Behav Neurosci. 2010 Feb; 124(1):133-140. Young JW, Wallace CK, Geyer MA, Risbrough VB. PMID: 20141288; PMCID: PMC3088993.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    153. The quantitative assessment of motor activity in mania and schizophrenia. J Affect Disord. 2010 Jan; 120(1-3):200-6. Minassian A, Henry BL, Geyer MA, Paulus MP, Young JW, Perry W. PMID: 19435640; PMCID: PMC2795051.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    154. Animal models of schizophrenia. Curr Top Behav Neurosci. 2010; 4:391-433. Young JW, Zhou X, Geyer MA. PMID: 21312408.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    155. GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior. Psychopharmacology (Berl). 2010 Feb; 208(3):443-54. Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA. PMID: 20020109; PMCID: PMC2806531.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    156. A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch Gen Psychiatry. 2009 Oct; 66(10):1072-80. Perry W, Minassian A, Paulus MP, Young JW, Kincaid MJ, Ferguson EJ, Henry BL, Zhuang X, Masten VL, Sharp RF, Geyer MA. PMID: 19805697; PMCID: PMC2897252.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimals
    157. Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacology (Berl). 2009 Nov; 206(4):699-714. Marston HM, Young JW, Martin FD, Serpa KA, Moore CL, Wong EH, Gold L, Meltzer LT, Azar MR, Geyer MA, Shahid M. PMID: 19462162; PMCID: PMC2755103.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    158. Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther. 2009 May; 122(2):150-202. Young JW, Powell SB, Risbrough V, Marston HM, Geyer MA. PMID: 19269307; PMCID: PMC2688712.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimals
    159. Dopamine D1 and D2 receptor family contributions to modafinil-induced wakefulness. J Neurosci. 2009 Mar 04; 29(9):2663-5. Young JW. PMID: 19261860; PMCID: PMC2697968.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    160. The 5-choice continuous performance test: evidence for a translational test of vigilance for mice. PLoS One. 2009; 4(1):e4227. Young JW, Light GA, Marston HM, Sharp R, Geyer MA. PMID: 19156216; PMCID: PMC2626630.
      View in: PubMed   Mentions: 92     Fields:    Translation:Animals
    161. Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. Behav Pharmacol. 2008 Sep; 19(5-6):562-5. Powell SB, Young JW, Ong JC, Caron MG, Geyer MA. PMID: 18690110; PMCID: PMC2693185.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    162. Progressive impairment in olfactory working memory in a mouse model of Mild Cognitive Impairment. Neurobiol Aging. 2009 Sep; 30(9):1430-43. Young JW, Sharkey J, Finlayson K. PMID: 18242780.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    163. A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern Monitor. Neurosci Biobehav Rev. 2007; 31(6):882-96. Young JW, Minassian A, Paulus MP, Geyer MA, Perry W. PMID: 17706782; PMCID: PMC2025688.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    164. The odour span task: a novel paradigm for assessing working memory in mice. Neuropharmacology. 2007 Feb; 52(2):634-45. Young JW, Kerr LE, Kelly JS, Marston HM, Spratt C, Finlayson K, Sharkey J. PMID: 17097694.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    165. Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol. 2007 Jan 15; 17(2):145-55. Young JW, Crawford N, Kelly JS, Kerr LE, Marston HM, Spratt C, Finlayson K, Sharkey J. PMID: 16650968.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    166. Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Neuropsychopharmacology. 2004 May; 29(5):891-900. Young JW, Finlayson K, Spratt C, Marston HM, Crawford N, Kelly JS, Sharkey J. PMID: 14970827.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
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