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William Freeman

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentOphthalmology
Address9500 Gilman Drive #0946
La Jolla CA 92093
Phone858-534-3513
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    Collapse Research 
    Collapse Research Activities and Funding
    P30 - CENTER CORE GRANT FOR VISION RESEARCH
    NIH/NEI P30EY022589Jul 1, 2012 - Jun 30, 2018
    Role: Co-Investigator
    Crystalline Antiproliferative Drugs for Intraocular Diseases
    NIH/NEI R01EY018589Sep 30, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Studies of Retinopathy of AIDS in the HAART Era
    NIH/NEI R01EY007366Dec 1, 1987 - Mar 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Warther D, Xiao Y, Li F, Wang Y, Huffman K, Freeman WR, Sailor M, Cheng L. Porous silicon based intravitreal platform for dual-drug loading and controlled release towards synergistic therapy. Drug Deliv. 2018 Nov; 25(1):1537-1545. PMID: 29996687.
      View in: PubMed
    2. Meshi A, Camacho N, Lin T, Muftuoglu IK, Arcinue CA, Gaber R, You QS, Freeman WR. Correlates of Good Vision in Eyes With Subfoveal Scars From Neovascular Age-Related Macular Degeneration. Ophthalmic Surg Lasers Imaging Retina. 2018 Oct 01; 49(10):765-774. PMID: 30395662.
      View in: PubMed
    3. Muftuoglu IK, Lin T, Freeman WR. Inner retinal thickening in newly diagnosed choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2018 Aug 09. PMID: 30094716.
      View in: PubMed
    4. Lin T, Dans K, Meshi A, Muftuoglu IK, Amador-Patarroyo MJ, Chen KC, Cheng L, Freeman WR. AGE-RELATED MACULAR DEGENERATION-ASSOCIATED PERIPAPILLARY CHOROIDAL NEOVASCULARIZATION IN THE ERA OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY. Retina. 2018 Jul 17. PMID: 30028411.
      View in: PubMed
    5. Meshi A, Chen KC, You QS, Dans K, Lin T, Bartsch DU, Cheng L, Amador-Patarroyo MJ, Muftuoglu IK, Gomez ML, Nudleman E, Freeman WR. ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions. Retina. 2018 Jul 13. PMID: 30015764.
      View in: PubMed
    6. Freeman WR, Chen KC, Ho J, Chao DL, Ferreyra HA, Tripathi AB, Nudleman E, Bartsch DU. RESOLUTION, DEPTH OF FIELD, AND PHYSICIAN SATISFACTION DURING DIGITALLY ASSISTED VITREORETINAL SURGERY. Retina. 2018 Jun 27. PMID: 29965938.
      View in: PubMed
    7. Kilic Muftuoglu I, Gomez ML, Afshari N, Uwe DB, Meshi A, Gaber R, You Q, Freeman WR. Tear film evaluation by scanning laser ophthalmoscopy during retinal imaging. Eur J Ophthalmol. 2018 May 01; 1120672117747039. PMID: 29726278.
      View in: PubMed
    8. Meshi A, Lin T, Dans K, Chen KC, Amador M, Hasenstab K, Muftuoglu IK, Nudleman E, Chao D, Bartsch DU, Freeman WR. COMPARISON OF RETINAL PATHOLOGY VISUALIZATION IN MULTISPECTRAL SCANNING LASER IMAGING. Retina. 2018 Mar 16. PMID: 29554078.
      View in: PubMed
    9. Muftuoglu IK, Alam M, You QS, Gaber R, Ramkumar HL, Mendoza N, Meshi A, Freeman WR. LONG-TERM REMISSION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION WITH AS-NEEDED ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY. Retina. 2018 Mar; 38(3):516-522. PMID: 28221254.
      View in: PubMed
    10. Muftuoglu IK, Gaber R, Bartsch DU, Meshi A, Goldbaum M, Freeman WR. Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions. Graefes Arch Clin Exp Ophthalmol. 2018 Apr; 256(4):643-649. PMID: 29492687.
      View in: PubMed
    11. Kilic Muftuoglu I, Bartsch DU, Barteselli G, Gaber R, Nezgoda J, Freeman WR. VISUALIZATION OF MACULAR PUCKER BY MULTICOLOR SCANNING LASER IMAGING. Retina. 2018 Feb; 38(2):352-358. PMID: 28151841.
      View in: PubMed
    12. Muftuoglu IK, Lin T, Nudleman E, Gaber R, Bartsch DU, Freeman WR. IDENTIFICATION OF FACTORS RELATED TO SUBFOVEAL DETACHMENT SECONDARY TO EPIRETINAL MEMBRANE. Retina. 2018 Jan 31. PMID: 29394236.
      View in: PubMed
    13. Moon SW, Sun Y, Warther D, Huffman K, Freeman WR, Sailor MJ, Cheng L. New model of proliferative vitreoretinopathy in rabbit for drug delivery and pharmacodynamic studies. Drug Deliv. 2018 Jan 01; 25(1):600-610. PMID: 29461171.
      View in: PubMed
    14. Ho J, Dans K, You Q, Nudleman EN, Freeman WR. COMPARISON OF 3 MM × 3 MM VERSUS 6 MM × 6 MM OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY SCAN SIZES IN THE EVALUATION OF NON-PROLIFERATIVE DIABETIC RETINOPATHY. Retina. 2017 Nov 22. PMID: 29190249.
      View in: PubMed
    15. Ramkumar HL, Nguyen B, Bartsch DU, Saunders LJ, Muftuoglu IK, You Q, Freeman WR. REDUCED GANGLION CELL VOLUME ON OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH GEOGRAPHIC ATROPHY. Retina. 2017 Nov 07. PMID: 29117065.
      View in: PubMed
    16. You QS, Meshi A, Muftuoglu IK, Freeman WR. Reply. Retina. 2017 11; 37(11):e141-e143. PMID: 29065081.
      View in: PubMed
    17. Chen M, Hou J, Tan G, Xie P, Freeman WR, Beadle JR, Hostetler KY, Cheng L. A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation. Drug Deliv. 2017 Nov; 24(1):1703-1712. PMID: 29115885.
      View in: PubMed
    18. Muftuoglu IK, Mendoza N, Gaber R, Alam M, You Q, Freeman WR. INTEGRITY OF OUTER RETINAL LAYERS AFTER RESOLUTION OF CENTRAL INVOLVED DIABETIC MACULAR EDEMA. Retina. 2017 Nov; 37(11):2015-2024. PMID: 28092342.
      View in: PubMed
    19. Gaber R, You QS, Muftuoglu IK, Alam M, Tsai FF, Mendoza N, Freeman WR. CHARACTERISTICS OF EPIRETINAL MEMBRANE REMNANT EDGE BY OPTICAL COHERENCE TOMOGRAPHY AFTER PARS PLANA VITRECTOMY. Retina. 2017 Nov; 37(11):2078-2083. PMID: 28590966.
      View in: PubMed
    20. Muftuoglu IK, Alam M, You QS, Gaber R, Ramkumar HL, Mendoza N, Meshi A, Freeman WR. Reply. Retina. 2017 09; 37(9):e110-e112. PMID: 28820853.
      View in: PubMed
    21. Muftuoglu IK, Tsai FF, Lin T, Freeman WR. High-Dose Decanted Triamcinolone for Treatment-Resistant Persistent Macular Edema. Ophthalmic Surg Lasers Imaging Retina. 2017 Sep 01; 48(9):717-726. PMID: 28902332.
      View in: PubMed
    22. Muftuoglu IK, Freeman WR. High-frequency aflibercept injections in persistent neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2017 10; 255(10):2069. PMID: 28780686.
      View in: PubMed
    23. Damle S, Lo YH, Freeman WR. High Visual Acuity Retinal Prosthesis: Understanding Limitations and Advancements Toward Functional Prosthetic Vision. Retina. 2017 08; 37(8):1423-1427. PMID: 28426627.
      View in: PubMed
    24. You Q, Freeman WR, Weinreb RN, Zangwill L, Manalastas PIC, Saunders LJ, Nudleman E. REPRODUCIBILITY OF VESSEL DENSITY MEASUREMENT WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH AND WITHOUT RETINOPATHY. Retina. 2017 Aug; 37(8):1475-1482. PMID: 27930458.
      View in: PubMed
    25. Muftuoglu IK, Tsai FF, Gaber R, Alam M, Meshi A, Freeman WR. Erratum to: High-frequency aflibercept injections in persistent neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2017 07; 255(7):1463. PMID: 28527039.
      View in: PubMed
    26. Muftuoglu IK, Ramkumar HL, Bartsch DU, Meshi A, Gaber R, Freeman WR. QUANTITATIVE ANALYSIS OF THE INNER RETINAL LAYER THICKNESSES IN AGE-RELATED MACULAR DEGENERATION USING CORRECTED OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION. Retina. 2017 Jun 23. PMID: 28650925.
      View in: PubMed
    27. You QS, Gaber R, Meshi A, Ramkumar HL, Alam M, Muftuoglu IK, Freeman WR. HIGH-DOSE HIGH-FREQUENCY AFLIBERCEPT FOR RECALCITRANT NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina. 2017 Jun 09. PMID: 28604541.
      View in: PubMed
    28. Muftuoglu IK, Tsai FF, Gaber R, Alam M, Meshi A, Freeman WR. High-frequency aflibercept injections in persistent neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2017 Apr; 255(4):709-717. PMID: 27878592.
      View in: PubMed
    29. Muftuoglu IK, Arcinue CA, Tsai FF, Alam M, Gaber R, Camacho N, Freeman WR. Reply. Am J Ophthalmol. 2017 Jan; 173:146. PMID: 27842697.
      View in: PubMed
    30. Muftuoglu IK, Arcinue CA, Alam M, Gaber R, Camacho N, You Q, Tsai FF, Freeman WR. Reply. Am J Ophthalmol. 2016 Oct; 170:247-248. PMID: 27646165.
      View in: PubMed
    31. Bartsch DU, Muftuoglu IK, Freeman WR. Laser Pointers Revisited. Retina. 2016 Sep; 36(9):1611-3. PMID: 27533775; PMCID: PMC4993644 [Available on 09/01/17].
    32. Ha S, Khraiche ML, Akinin A, Jing Y, Damle S, Kuang Y, Bauchner S, Lo YH, Freeman WR, Silva GA, Cauwenberghs G. Towards high-resolution retinal prostheses with direct optical addressing and inductive telemetry. J Neural Eng. 2016 10; 13(5):056008. PMID: 27529371.
      View in: PubMed
    33. Alam MR, Arcinue CA, Mendoza NB, Freeman WR. RECALCITRANT CYSTOID MACULAR EDEMA AFTER PARS PLANA VITRECTOMY. Retina. 2016 Jul; 36(7):1244-51. PMID: 26655611.
      View in: PubMed
    34. You QS, Bartsch DU, Espina M, Alam M, Camacho N, Mendoza N, Freeman WR. REPRODUCIBILITY OF MACULAR PIGMENT OPTICAL DENSITY MEASUREMENT BY TWO-WAVELENGTH AUTOFLUORESCENCE IN A CLINICAL SETTING. Retina. 2016 Jul; 36(7):1381-7. PMID: 26655614; PMCID: PMC4903092 [Available on 07/01/17].
    35. Barteselli G, Bartsch DU, Weinreb RN, Camacho N, Nezgoda JT, Marvasti AH, Freeman WR. REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography. Retina. 2016 Jun; 36(6):1153-61. PMID: 26562563; PMCID: PMC4864215 [Available on 06/01/17].
    36. Muftuoglu IK, Arcinue CA, Tsai FF, Alam M, Gaber R, Camacho N, You Q, Freeman WR. Long-Term Results of Pro Re Nata Regimen of Aflibercept Treatment in Persistent Neovascular Age-Related Macular Degeneration. Am J Ophthalmol. 2016 Jul; 167:1-9. PMID: 27049000.
      View in: PubMed
    37. Hou H, Wang C, Nan K, Freeman WR, Sailor MJ, Cheng L. Controlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):557-66. PMID: 26882530; PMCID: PMC4758302.
    38. Espina MP, Arcinue CA, Ma F, Camacho N, Bartsch DU, Freeman WR. ANALYSIS OF A CONFOCAL SCANNING LASER OPHTHALMOSCOPE NONCONTACT ULTRA-WIDE FIELD LENS SYSTEM IN RETINAL AND CHOROIDAL DISEASE. Retina. 2015 Dec; 35(12):2664-8. PMID: 26584439; PMCID: PMC4699305 [Available on 12/01/16].
    39. Klingenstein A, Schaumberger MM, Freeman WR, Folberg R, Mueller AJ, Schaller UC. MuSIC report III: tumour microcirculation patterns and development of metastasis in long-term follow-up of melanocytic uveal tumours. Acta Ophthalmol. 2016 Mar; 94(2):175-81. PMID: 26426375.
      View in: PubMed
    40. Espina M, Arcinue CA, Ma F, Camacho N, Barteselli G, Mendoza N, Ferrara N, Freeman WR. Outer retinal tubulations response to anti-VEGF treatment. Br J Ophthalmol. 2016 06; 100(6):819-23. PMID: 26423451.
      View in: PubMed
    41. Ramkumar HL, Khatibi A, Freeman WR, Barteselli G, Ezon IC, Amini P, Sharpsten L, Arcinue CA, Nezgoda JT, Ferreyra HA, Goldbaum MH. Visual phenomena perceived during pars plana vitrectomy under peribulbar block and monitored anaesthesia care. Br J Ophthalmol. 2016 06; 100(6):777-81. PMID: 26385093.
      View in: PubMed
    42. Hartmann KI, Oster SF, Amini P, Bartsch DU, Cheng L, Freeman WR. SLO-Microperimetry in Wet Age-Related Macular Degeneration During Anti-VEGF Therapy. Ophthalmic Surg Lasers Imaging Retina. 2015 Sep; 46(8):824-30. PMID: 26431297.
      View in: PubMed
    43. Bartsch DU, Kozak I, Grant I, Knudsen VL, Weinreb RN, Lee BR, Freeman WR. Retinal Nerve Fiber and Optic Disc Morphology in Patients with Human Immunodeficiency Virus Using the Heidelberg Retina Tomography 3. PLoS One. 2015; 10(8):e0133144. PMID: 26258547; PMCID: PMC4530938.
    44. Arcinue CA, Bartsch DU, El-Emam SY, Ma F, Doede A, Sharpsten L, Gomez ML, Freeman WR. Retinal Thickening and Photoreceptor Loss in HIV Eyes without Retinitis. PLoS One. 2015; 10(8):e0132996. PMID: 26244973; PMCID: PMC4526563.
    45. Hou H, Nieto A, Belghith A, Nan K, Li Y, Freeman WR, Sailor MJ, Cheng L. A sustained intravitreal drug delivery system with remote real time monitoring capability. Acta Biomater. 2015 Sep; 24:309-21. PMID: 26087110; PMCID: PMC4560601.
    46. Arcinue CA, Ma F, Barteselli G, Sharpsten L, Gomez ML, Freeman WR. Reply: To PMID 25461263. Am J Ophthalmol. 2015 May; 159(5):997. PMID: 25867596.
      View in: PubMed
    47. Hou H, Huffman K, Rios S, Freeman WR, Sailor MJ, Cheng L. A Novel Approach of Daunorubicin Application on Formation of Proliferative Retinopathy Using a Porous Silicon Controlled Delivery System: Pharmacodynamics. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2755-63. PMID: 25829415; PMCID: PMC4416660.
    48. Camacho N, Barteselli G, Nezgoda JT, El-Emam S, Cheng L, Bartsch DU, Freeman WR. Significance of the hyperautofluorescent ring associated with choroidal neovascularisation in eyes undergoing anti-VEGF therapy for wet age-related macular degeneration. Br J Ophthalmol. 2015 Sep; 99(9):1277-83. PMID: 25777818.
      View in: PubMed
    49. Nieto A, Hou H, Moon SW, Sailor MJ, Freeman WR, Cheng L. Surface engineering of porous silicon microparticles for intravitreal sustained delivery of rapamycin. Invest Ophthalmol Vis Sci. 2015 Jan 22; 56(2):1070-80. PMID: 25613937; PMCID: PMC4329946.
    50. Barteselli G, Amini P, Ezon IC, Nezgoda JT, Cheng L, Freeman WR. Impact on intraocular pressure after 20-mg decanted triamcinolone acetonide (kenalog) injection when using prophylactic antiglaucoma therapy. Retina. 2015 Jan; 35(1):75-81. PMID: 25077534; PMCID: PMC4276472.
    51. Tsai FF, Freeman WR. Correspondence. Retina. 2015 Jan; 35(1):e10-1. PMID: 25473791.
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    52. Ma F, Nan K, Lee S, Beadle JR, Hou H, Freeman WR, Hostetler KY, Cheng L. Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system. Eur J Pharm Biopharm. 2015 Jan; 89:271-9. PMID: 25513956; PMCID: PMC4355386.
    53. Arcinue CA, Ma F, Barteselli G, Sharpsten L, Gomez ML, Freeman WR. One-year outcomes of aflibercept in recurrent or persistent neovascular age-related macular degeneration. Am J Ophthalmol. 2015 Mar; 159(3):426-36.e2. PMID: 25461263; PMCID: PMC4329256.
    54. Wang C, Hou H, Nan K, Sailor MJ, Freeman WR, Cheng L. Intravitreal controlled release of dexamethasone from engineered microparticles of porous silicon dioxide. Exp Eye Res. 2014 Dec; 129:74-82. PMID: 25446320; PMCID: PMC4259850.
    55. Kozak I, El-Emam SY, Cheng L, Bartsch DU, Chhablani J, Freeman WR, Arevalo JF. Fluorescein angiography versus optical coherence tomography-guided planning for macular laser photocoagulation in diabetic macular edema. Retina. 2014 Aug; 34(8):1600-5. PMID: 24695064; PMCID: PMC4695978.
    56. Ezon IC, Barteselli G, Rosenberg J, Freeman WR. Concurrent primary vitreoretinal and spinal cord lymphoma: a unique entity. JAMA Ophthalmol. 2014 Jul; 132(7):902-4. PMID: 25010176.
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    57. Barteselli G, Chhablani J, Gomez ML, Doede AL, Dustin L, Kozak I, Bartsch DU, Azen SP, Letendre SL, Freeman WR. Visual function assessment in simulated real-life situations in HIV-infected subjects. PLoS One. 2014; 9(5):e97023. PMID: 24809827; PMCID: PMC4014600.
    58. Nan K, Ma F, Hou H, Freeman WR, Sailor MJ, Cheng L. Porous silicon oxide-PLGA composite microspheres for sustained ocular delivery of daunorubicin. Acta Biomater. 2014 Aug; 10(8):3505-12. PMID: 24793657; PMCID: PMC4106702.
    59. Barteselli G, Lee SN, El-Emam S, Hou H, Ma F, Chhablani J, Conner L, Cheng L, Bartsch DU, Freeman WR. Macular choroidal volume variations in highly myopic eyes with myopic traction maculopathy and choroidal neovascularization. Retina. 2014 May; 34(5):880-9. PMID: 24217703.
      View in: PubMed
    60. Barteselli G, Kozak I, El-Emam S, Chhablani J, Cortes MA, Freeman WR. 12-month results of the standardised combination therapy for diabetic macular oedema: intravitreal bevacizumab and navigated retinal photocoagulation. Br J Ophthalmol. 2014 Aug; 98(8):1036-41. PMID: 24723616; PMCID: PMC4112433.
    61. Hartmann KI, Schuster AK, Bartsch DU, Kim JS, Chhablani J, Freeman WR. Restoration of retinal layers after epiretinal membrane peeling. Retina. 2014 Apr; 34(4):647-54. PMID: 24077089; PMCID: PMC3968227.
    62. Ma F, Arcinue CA, Barteselli G, Cheng L, Ezon I, Lee SN, Freeman WR. Optical coherence tomography findings of the vitreoretinal interface in asymptomatic fellow eyes of patients with acute posterior vitreous detachment. Retina. 2014 Mar; 34(3):447-54. PMID: 24136409.
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    63. Hou H, Nieto A, Ma F, Freeman WR, Sailor MJ, Cheng L. Tunable sustained intravitreal drug delivery system for daunorubicin using oxidized porous silicon. J Control Release. 2014 Mar 28; 178:46-54. PMID: 24424270; PMCID: PMC3951847.
    64. Wang H, Barteselli G, Freeman WR, Lee SN, Chhablani J, El-Emam S, Cheng L. Temporal pattern of resolution/recurrence of choroidal neovascularization during bevacizumab therapy for wet age-related macular degeneration. Int J Ophthalmol. 2013; 6(5):600-5. PMID: 24195033; PMCID: PMC3808905.
    65. Kozak I, Sasik R, Freeman WR, Sprague LJ, Gomez ML, Cheng L, El-Emam S, Mojana F, Bartsch DU, Bosten J, Ayyagari R, Hardiman G. A degenerative retinal process in HIV-associated non-infectious retinopathy. PLoS One. 2013; 8(9):e74712. PMID: 24069333.
      View in: PubMed
    66. Nieto A, Hou H, Sailor MJ, Freeman WR, Cheng L. Ocular silicon distribution and clearance following intravitreal injection of porous silicon microparticles. Exp Eye Res. 2013 Nov; 116:161-8. PMID: 24036388; PMCID: PMC3873878.
    67. Barteselli G, Chhablani J, Lee SN, Wang H, El Emam S, Kozak I, Cheng L, Bartsch DU, Azen S, Freeman WR. Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography. Retina. 2013 Sep; 33(8):1574-83. PMID: 23584697; PMCID: PMC3804067.
    68. Barteselli G, Bartsch DU, Viola F, Mojana F, Pellegrini M, Hartmann KI, Benatti E, Leicht S, Ratiglia R, Staurenghi G, Weinreb RN, Freeman WR. Accuracy of the Heidelberg Spectralis in the alignment between near-infrared image and tomographic scan in a model eye: a multicenter study. Am J Ophthalmol. 2013 Sep; 156(3):588-92. PMID: 23769196; PMCID: PMC3748183.
    69. El-Emam S, Chhablani J, Barteselli G, Wang H, Lee SN, Kozak I, Cheng L, Freeman WR. Correlation of spectral domain optical coherence tomography characteristics with visual acuity in eyes with subfoveal scarring after treatment for wet age-related macular degeneration. Retina. 2013 Jun; 33(6):1249-57. PMID: 23446655.
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    70. Chhablani J, Bartsch DU, Cheng L, Gomez L, Alshareef RA, Rezeq SS, Garg SJ, Burgansky-Eliash Z, Freeman WR. Segmental reproducibility of retinal blood flow velocity measurements using retinal function imager. Graefes Arch Clin Exp Ophthalmol. 2013 Dec; 251(12):2665-70. PMID: 23700326; PMCID: PMC3865139.
    71. Hartmann KI, Nieto A, Wu EC, Freeman WR, Kim JS, Chhablani J, Sailor MJ, Cheng L. Hydrosilylated porous silicon particles function as an intravitreal drug delivery system for daunorubicin. J Ocul Pharmacol Ther. 2013 Jun; 29(5):493-500. PMID: 23448595; PMCID: PMC3669596.
    72. Chhablani J, Kim JS, Freeman WR, Kozak I, Wang HY, Cheng L. Predictors of visual outcome in eyes with choroidal neovascularization secondary to age related macular degeneration treated with intravitreal bevacizumab monotherapy. Int J Ophthalmol. 2013; 6(1):62-6. PMID: 23549041; PMCID: PMC3580252.
    73. Lee SN, Chhablani J, Chan CK, Wang H, Barteselli G, El-Emam S, Gomez ML, Kozak I, Cheng L, Freeman WR. Characterization of microaneurysm closure after focal laser photocoagulation in diabetic macular edema. Am J Ophthalmol. 2013 May; 155(5):905-12. PMID: 23394906; PMCID: PMC3627831.
    74. Chhablani J, Nieto A, Hou H, Wu EC, Freeman WR, Sailor MJ, Cheng L. Oxidized porous silicon particles covalently grafted with daunorubicin as a sustained intraocular drug delivery system. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):1268-79. PMID: 23322571; PMCID: PMC3576052.
    75. Neubauer AS, Langer J, Liegl R, Haritoglou C, Wolf A, Kozak I, Seidensticker F, Ulbig M, Freeman WR, Kampik A, Kernt M. Navigated macular laser decreases retreatment rate for diabetic macular edema: a comparison with conventional macular laser. Clin Ophthalmol. 2013; 7:121-8. PMID: 23345966; PMCID: PMC3551463.
    76. Barteselli G, Bartsch DU, Freeman WR. Combined depth imaging using optical coherence tomography as a novel imaging technique to visualize vitreoretinal choroidal structures. Retina. 2013 Jan; 33(1):247-8. PMID: 23138345; PMCID: PMC3808243.
    77. Khraiche ML, El Emam S, Akinin A, Cauwenberghs G, Freeman W, Silva GA. Visual evoked potential characterization of rabbit animal model for retinal prosthesis research. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:3539-42. PMID: 24110493.
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    78. Barteselli G, Bartsch DU, El-Emam S, Gomez ML, Chhablani J, Lee SN, Conner L, Freeman WR. Combined depth imaging technique on spectral-domain optical coherence tomography. Am J Ophthalmol. 2013 Apr; 155(4):727-32, 732.e1. PMID: 23253912; PMCID: PMC3608846.
    79. Chhablani J, Barteselli G, Bartsch DU, Kozak I, Wang H, El-Emam S, Doede AL, Cheng L, Freeman WR. Influence of scanning density on macular choroidal volume measurement using spectral-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2013 May; 251(5):1303-9. PMID: 23142990; PMCID: PMC3593737.
    80. Chhablani J, Kozak IR, Mojana F, Cheng L, Morrison VL, Wang H, Kim JS, Dustin L, Azen S, Freeman WR. Fundus autofluorescence not predictive of treatment response to intravitreal bevacizumab in exudative age-related macular degeneration. Retina. 2012 Sep; 32(8):1465-70. PMID: 22466489.
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    81. Hartmann KI, Gomez ML, Bartsch DU, Schuster AK, Freeman WR. Effect of change in drusen evolution on photoreceptor inner segment/outer segment junction. Retina. 2012 Sep; 32(8):1492-9. PMID: 22481478; PMCID: PMC3792858.
    82. Witkin AJ, Alshareef RA, Rezeq SS, Sampat KM, Chhablani J, Bartsch DU, Freeman WR, Haller JA, Garg SJ. Comparative analysis of the retinal microvasculature visualized with fluorescein angiography and the retinal function imager. Am J Ophthalmol. 2012 Nov; 154(5):901-907.e2. PMID: 22935597.
      View in: PubMed
    83. Barteselli G, Chhablani J, El-Emam S, Wang H, Chuang J, Kozak I, Cheng L, Bartsch DU, Freeman WR. Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis. Ophthalmology. 2012 Dec; 119(12):2572-8. PMID: 22921388.
      View in: PubMed
    84. Kim JS, Beadle JR, Freeman WR, Hostetler KY, Hartmann K, Valiaeva N, Kozak I, Conner L, Trahan J, Aldern KA, Cheng L. A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy. Mol Vis. 2012; 18:1907-17. PMID: 22876115; PMCID: PMC3413433.
    85. Kozak I, Ahuja A, Gangaputra S, Van Natta ML, Thorne JE, Freeman WR. Optic nerve head morphology and visual field function in patients with AIDS and without infectious retinitis. Ocul Immunol Inflamm. 2012 Oct; 20(5):342-8. PMID: 22697270; PMCID: PMC4164231.
    86. Kozak I, Kim JS, Oster SF, Chhablani J, Freeman WR. Focal navigated laser photocoagulation in retinovascular disease: clinical results in initial case series. Retina. 2012 May; 32(5):930-5. PMID: 21886017.
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    87. Chhablani J, Barteselli G, Wang H, El-Emam S, Kozak I, Doede AL, Bartsch DU, Cheng L, Freeman WR. Repeatability and reproducibility of manual choroidal volume measurements using enhanced depth imaging optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2274-80. PMID: 22427584; PMCID: PMC3995568.
    88. Taylor SR, Lightman SL, Sugar EA, Jaffe GJ, Freeman WR, Altaweel MM, Kozak I, Holbrook JT, Jabs DA, Kempen JH. The impact of macular edema on visual function in intermediate, posterior, and panuveitis. Ocul Immunol Inflamm. 2012 Jun; 20(3):171-81. PMID: 22530874; PMCID: PMC3643807.
    89. Chan CK, Chhablani J, Freeman WR. Prognostic indicators for no light perception after open-globe injury: eye injury vitrectomy study. Am J Ophthalmol. 2012 Apr; 153(4):777; author reply 778. PMID: 22445633.
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    90. Chhablani JK, Kim JS, Cheng L, Kozak I, Freeman W. External limiting membrane as a predictor of visual improvement in diabetic macular edema after pars plana vitrectomy. Graefes Arch Clin Exp Ophthalmol. 2012 Oct; 250(10):1415-20. PMID: 22354371.
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    91. Singer MA, Awh CC, Sadda S, Freeman WR, Antoszyk AN, Wong P, Tuomi L. HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology. 2012 Jun; 119(6):1175-83. PMID: 22306121.
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    92. Wang H, Chhablani J, Freeman WR, Chan CK, Kozak I, Bartsch DU, Cheng L. Characterization of diabetic microaneurysms by simultaneous fluorescein angiography and spectral-domain optical coherence tomography. Am J Ophthalmol. 2012 May; 153(5):861-867.e1. PMID: 22300473; PMCID: PMC3331899.
    93. Wang H, Chhablani J, Freeman WR, Beadle JR, Hostetler KY, Hartmann K, Conner L, Aldern KA, Pearson L, Cheng L. Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug. Invest Ophthalmol Vis Sci. 2011 Dec 09; 52(13):9391-6. PMID: 22058340; PMCID: PMC3250264.
    94. Kim JS, Chhablani J, Chan CK, Cheng L, Kozak I, Hartmann K, Freeman WR. Retinal adherence and fibrillary surface changes correlate with surgical difficulty of epiretinal membrane removal. Am J Ophthalmol. 2012 Apr; 153(4):692-7, 697.e1-2. PMID: 22137206; PMCID: PMC3297697.
    95. Chhablani JK, Freeman W. Predictors of visual acuity in macular edema. Invest Ophthalmol Vis Sci. 2011 Nov 29; 52(12):9287. PMID: 22127431.
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    96. Freeman WR, Kozak I, Yuson RM, Nigam N, Cheng L, Mojana F. Prognosti implications of pigment epithelial detachment in bevacizumab (avastin)-treated eyes with age-related macular degeneration and choroidal neovascularization. Retina. 2011 Oct; 31(9):1812-8. PMID: 21866073.
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    97. Oster SF, Mojana F, Freeman WR. Spectral-domain optical coherence tomography imaging of postoperative scleral buckles. Retina. 2011 Sep; 31(8):1493-9. PMID: 21386759.
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    98. Kozak I, Freeman WR. Infectious retinitis and retinal disease in human immunodeficiency virus-infected individuals: a photographic atlas. Retina. 2011 Aug; 31(7 Suppl):S1-42. PMID: 21836419.
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    99. Cheng S, Klein H, Bartsch DU, Kozak I, Marcotte TD, Freeman WR. Relationship between retinal nerve fiber layer thickness and driving ability in patients with human immunodeficiency virus infection. Graefes Arch Clin Exp Ophthalmol. 2011 Nov; 249(11):1643-7. PMID: 21732109; PMCID: PMC4144406.
    100. Kim JS, Maheshwary AS, Bartsch DU, Cheng L, Gomez ML, Hartmann K, Freeman WR. The microperimetry of resolved cotton-wool spots in eyes of patients with hypertension and diabetes mellitus. Arch Ophthalmol. 2011 Jul; 129(7):879-84. PMID: 21746978.
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    101. Hartmann KI, Bartsch DU, Cheng L, Kim JS, Gomez ML, Klein H, Freeman WR. Scanning laser ophthalmoscope imaging stabilized microperimetry in dry age-related macular degeneration. Retina. 2011 Jul-Aug; 31(7):1323-31. PMID: 21540764.
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    102. Vosganian GS, Boisot S, Hartmann KI, Freeman WR, Sharpe RW, Tripuraneni P, Saven A. Primary intraocular lymphoma: a review. J Neurooncol. 2011 Nov; 105(2):127-34. PMID: 21626069.
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    103. Chhablani JK, Bartsch DU, Freeman W. Association between the macular volume and visual acuity was found to be weak. Retina. 2011 Apr; 31(4):815; author reply 815-6. PMID: 21394056.
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    104. Hou J, Li Y, Zhou Z, Valiaeva N, Beadle JR, Hostetler K, Freeman WR, Hu DN, Chen H, Cheng L. Antiproliferative property of hexadecyloxypropyl 9-[2-(phosphonomethoxy) ethyl] guanine (HDP-PMEG) for unwanted ocular proliferation. Mol Vis. 2011 Mar 02; 17:627-37. PMID: 21386925; PMCID: PMC3049735.
    105. Chen Y, Zeng J, Zhao C, Wang K, Trood E, Buehler J, Weed M, Kasuga D, Bernstein PS, Hughes G, Fu V, Chin J, Lee C, Crocker M, Bedell M, Salasar F, Yang Z, Goldbaum M, Ferreyra H, Freeman WR, Kozak I, Zhang K. Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. Arch Ophthalmol. 2011 Mar; 129(3):344-51. PMID: 21402993; PMCID: PMC4134685.
    106. Cheng L, Beadle JR, Tammewar A, Hostetler KY, Hoh C, Freeman WR. Intraocular pharmacokinetics of a crystalline lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis. J Ocul Pharmacol Ther. 2011 Apr; 27(2):157-62. PMID: 21351867; PMCID: PMC3078534.
    107. Mojana F, Brar M, Cheng L, Bartsch DU, Freeman WR. Long-term SD-OCT/SLO imaging of neuroretina and retinal pigment epithelium after subthreshold infrared laser treatment of drusen. Retina. 2011 Feb; 31(2):235-42. PMID: 21157398; PMCID: PMC3530923.
    108. Kozak I, Oster SF, Cortes MA, Dowell D, Hartmann K, Kim JS, Freeman WR. Clinical evaluation and treatment accuracy in diabetic macular edema using navigated laser photocoagulator NAVILAS. Ophthalmology. 2011 Jun; 118(6):1119-24. PMID: 21269701.
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    109. Khraiche ML, Lo Y, Wang D, Cauwenberghs G, Freeman W, Silva GA. Ultra-high photosensitivity silicon nanophotonics for retinal prosthesis: electrical characteristics. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:2933-6. PMID: 22254955.
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    110. Wu EC, Andrew JS, Cheng L, Freeman WR, Pearson L, Sailor MJ. Real-time monitoring of sustained drug release using the optical properties of porous silicon photonic crystal particles. Biomaterials. 2011 Mar; 32(7):1957-66. PMID: 21122914; PMCID: PMC3025697.
    111. Brar M, Cheng L, Yuson R, Mojana F, Freeman WR, Gill PS. Ocular safety profile and intraocular pharmacokinetics of an antagonist of EphB4/EphrinB2 signalling. Br J Ophthalmol. 2010 Dec; 94(12):1668-73. PMID: 20934994.
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    112. Goldbaum MH, Kozak I, Hao J, Sample PA, Lee T, Grant I, Freeman WR. Pattern recognition can detect subtle field defects in eyes of HIV individuals without retinitis under HAART. Graefes Arch Clin Exp Ophthalmol. 2011 Apr; 249(4):491-8. PMID: 20865422; PMCID: PMC3070878.
    113. Andrew JS, Anglin EJ, Wu EC, Chen MY, Cheng L, Freeman WR, Sailor MJ. Sustained Release of a Monoclonal Antibody from Electrochemically Prepared Mesoporous Silicon Oxide. Adv Funct Mater. 2010 Sep 08; 20(23):4168-4174. PMID: 21274422.
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    114. Brar M, Kozak I, Freeman WR, Oster SF, Mojana F, Yuson RM. Vitreoretinal interface abnormalities in healed cytomegalovirus retinitis. Retina. 2010 Sep; 30(8):1262-6. PMID: 20517176.
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    115. Falkenstein IA, Cheng L, Jones TR, Freeman WR, Babson B, Kozak I, Tammewar AM, Barron EC. Intraocular properties of a repository urokinase receptor antagonist a36 Peptide in rabbits. Curr Eye Res. 2010 Aug; 35(8):742-50. PMID: 20673051.
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    116. Oster SF, Mojana F, Bartsch DU, Goldbaum M, Freeman WR. Dynamics of the macular hole-silicone oil tamponade interface with patient positioning as imaged by spectral domain-optical coherence tomography. Retina. 2010 Jun; 30(6):924-9. PMID: 20531144; PMCID: PMC2883797.
    117. Kozak I, Cheng L, Rought S, Woelk C, Hardiman G, Barron E, Schrier RD, Corbeil J, Freeman WR. Characterization of cytokine gene expression associated with noninfectious human immunodeficiency virus retinopathy in human autopsy eyes. Retina. 2010 Jun; 30(6):952-7. PMID: 20084053.
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    118. Maheshwary AS, Oster SF, Yuson RM, Cheng L, Mojana F, Freeman WR. The association between percent disruption of the photoreceptor inner segment-outer segment junction and visual acuity in diabetic macular edema. Am J Ophthalmol. 2010 Jul; 150(1):63-67.e1. PMID: 20451897; PMCID: PMC2900476.
    119. Oster SF, Mojana F, Brar M, Yuson RM, Cheng L, Freeman WR. Disruption of the photoreceptor inner segment/outer segment layer on spectral domain-optical coherence tomography is a predictor of poor visual acuity in patients with epiretinal membranes. Retina. 2010 May; 30(5):713-8. PMID: 20038861.
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    120. Shah AM, Oster SF, Freeman WR. Viral retinitis after intravitreal triamcinolone injection in patients with predisposing medical comorbidities. Am J Ophthalmol. 2010 Mar; 149(3):433-40.e1. PMID: 20172069; PMCID: PMC2905234.
    121. Brar M, Yuson R, Kozak I, Mojana F, Cheng L, Bartsch DU, Oster SF, Freeman WR. Correlation between morphologic features on spectral-domain optical coherence tomography and angiographic leakage patterns in macular edema. Retina. 2010 Mar; 30(3):383-9. PMID: 20216291; PMCID: PMC2870721.
    122. Freeman SR, Kozak I, Cheng L, Bartsch DU, Mojana F, Nigam N, Brar M, Yuson R, Freeman WR. Optical coherence tomography-raster scanning and manual segmentation in determining drusen volume in age-related macular degeneration. Retina. 2010 Mar; 30(3):431-5. PMID: 19952989.
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    123. Mojana F, Kozak I, Oster SF, Cheng L, Bartsch DU, Brar M, Yuson RM, Freeman WR. Observations by spectral-domain optical coherence tomography combined with simultaneous scanning laser ophthalmoscopy: imaging of the vitreous. Am J Ophthalmol. 2010 Apr; 149(4):641-50. PMID: 20138610.
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    124. Nigam N, Bartsch DU, Cheng L, Brar M, Yuson RM, Kozak I, Mojana F, Freeman WR. Spectral domain optical coherence tomography for imaging ERM, retinal edema, and vitreomacular interface. Retina. 2010 Feb; 30(2):246-53. PMID: 19940804.
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    125. Friberg TR, Brennen PM, Freeman WR, Musch DC. Prophylactic treatment of age-related macular degeneration report number 2: 810-nanometer laser to eyes with drusen: bilaterally eligible patients. Ophthalmic Surg Lasers Imaging. 2009 Nov-Dec; 40(6):530-8. PMID: 19928717.
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    126. Gomez ML, Mojana F, Bartsch DU, Freeman WR. Imaging of long-term retinal damage after resolved cotton wool spots. Ophthalmology. 2009 Dec; 116(12):2407-14. PMID: 19815278; PMCID: PMC4172325.
    127. Lee BR, Bartsch DU, Kozak I, Cheng L, Freeman WR. Comparison of a novel confocal scanning laser ophthalmoscopy algorithm with optical coherence tomography in measurement of macular thickness and volume. Retina. 2009 Oct; 29(9):1328-34. PMID: 19934823.
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    128. Bessho K, Bartsch DU, Gomez L, Cheng L, Koh HJ, Freeman WR. Ocular wavefront aberrations in patients with macular diseases. Retina. 2009 Oct; 29(9):1356-63. PMID: 19574950; PMCID: PMC3711882.
    129. Yuson RM, Nigam N, Mojana F, Brar M, Oster SF, Freeman WR. The use of intraoperative indocyanine green dye to assist in epiretinal membrane removal: a novel application of indocyanine green surgical use. Retina. 2009 Oct; 29(9):1367-70. PMID: 19934827.
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    130. Cheng L, Hostetler K, Valiaeva N, Tammewar A, Freeman WR, Beadle J, Bartsch DU, Aldern K, Falkenstein I. Intravitreal crystalline drug delivery for intraocular proliferation diseases. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):474-81. PMID: 19696179; PMCID: PMC2869063.
    131. Pathak S, Tolentino R, Nguyen K, D'Amico L, Barron E, Cheng L, Freeman WR, Silva GA. Quantum dot labeling and imaging of glial fibrillary acidic protein intermediate filaments and gliosis in the rat neural retina and dissociated astrocytes. J Nanosci Nanotechnol. 2009 Aug; 9(8):5047-54. PMID: 19928184.
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    132. Brar M, Kozak I, Cheng L, Bartsch DU, Yuson R, Nigam N, Oster SF, Mojana F, Freeman WR. Correlation between spectral-domain optical coherence tomography and fundus autofluorescence at the margins of geographic atrophy. Am J Ophthalmol. 2009 Sep; 148(3):439-44. PMID: 19541290; PMCID: PMC2731819.
    133. Cheng L, Banker AS, Martin M, Kozak I, Freeman WR. Triamcinolone acetonide concentration of aqueous humor after decanted 20-mg intravitreal injection. Ophthalmology. 2009 Jul; 116(7):1356-9. PMID: 19450879.
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    134. Lipson J, Bernhardt J, Block U, Freeman WR, Hofmeister R, Hristakeva M, Lenosky T, McNamara R, Petrasek D, Veltkamp D, Waydo S. Requirements for calibration in noninvasive glucose monitoring by Raman spectroscopy. J Diabetes Sci Technol. 2009 Mar 01; 3(2):233-41. PMID: 20144354; PMCID: PMC2771519.
    135. Chung EJ, Freeman WR, Azen SP, Lee H, Koh HJ. Comparison of combination posterior sub-tenon triamcinolone and modified grid laser treatment with intravitreal triamcinolone treatment in patients with diffuse diabetic macular edema. Yonsei Med J. 2008 Dec 31; 49(6):955-64. PMID: 19108019; PMCID: PMC2628026.
    136. Hedaya J, Nigam N, Freeman WR. Scleral Buckling versus Vitrectomy. Ophthalmology. 2008 Sep; 115(9):1634-5; author reply 1635. PMID: 18762077.
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    137. Falkenstein IA, Cheng L, Wong-Staal F, Tammewar AM, Barron EC, Silva GA, Li QX, Yu D, Hysell M, Liu G, Ke N, Macdonald JE, Freeman WR. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul; 33(7):599-609. PMID: 18600493; PMCID: PMC2664073.
    138. Mojana F, Cheng L, Bartsch DU, Silva GA, Kozak I, Nigam N, Freeman WR. The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol. 2008 Aug; 146(2):218-227. PMID: 18538742; PMCID: PMC2735863.
    139. Hedaya J, Freeman WR. The effect of treatments given to patients before initiation of anti-vascular endothelial growth factor treatment. Retina. 2008 Jun; 28(6):911-2; author reply 912. PMID: 18536615.
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    140. Anglin EJ, Cheng L, Freeman WR, Sailor MJ. Porous silicon in drug delivery devices and materials. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1266-77. PMID: 18508154; PMCID: PMC2710886.
    141. Kozak I, Morrison VL, Clark TM, Bartsch DU, Lee BR, Falkenstein I, Tammewar AM, Mojana F, Freeman WR. Discrepancy between fluorescein angiography and optical coherence tomography in detection of macular disease. Retina. 2008 Apr; 28(4):538-44. PMID: 18398354; PMCID: PMC2666014.
    142. Falkenstein IA, Bartsch DU, Azen SP, Dustin L, Sadun AA, Freeman WR. Multifocal electroretinography in HIV-positive patients without infectious retinitis. Am J Ophthalmol. 2008 Oct; 146(4):579-88. PMID: 18280451; PMCID: PMC2614872.
    143. Chung EJ, Freeman WR, Koh HJ. Visual acuity and multifocal electroretinographic changes after arteriovenous crossing sheathotomy for macular edema associated with branch retinal vein occlusion. Retina. 2008 Feb; 28(2):220-5. PMID: 18301026; PMCID: PMC2674764.
    144. Freeman WR, Van Natta ML, Jabs D, Sample PA, Sadun AA, Thorne J, Shah KH, Holland GN. Vision function in HIV-infected individuals without retinitis: report of the Studies of Ocular Complications of AIDS Research Group. Am J Ophthalmol. 2008 Mar; 145(3):453-462. PMID: 18191094; PMCID: PMC2359724.
    145. Kozak I, Bartsch DU, Freeman WR. Use of coronal simultaneous optical coherence tomography/scanning laser ophthalmoscopy to demonstrate cystoid macular edema secondary to extrafoveal retinal hole. Retin Cases Brief Rep. 2008; 2(2):91-3. PMID: 19759837.
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    146. Goldbaum MH, Falkenstein I, Kozak I, Hao J, Bartsch DU, Sejnowski T, Freeman WR. Analysis with support vector machine shows HIV-positive subjects without infectious retinitis have mfERG deficiencies compared to normal eyes. Trans Am Ophthalmol Soc. 2008; 106:196-204; discussion 204-5. PMID: 19277235; PMCID: PMC2646437.
    147. Lee J, Freeman WR, Azen SP, Chung EJ, Koh HJ. Prospective, randomized clinical trial of intravitreal triamcinolone treatment of neovascular age-related macular degeneration: one-year results. Retina. 2007 Nov-Dec; 27(9):1205-13. PMID: 18046226.
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    148. Kozak I, Cheng L, Silva GA, Freeman WR. Testing of intraocular drugs for clinical use. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):4861-3. PMID: 17962431.
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    149. Kozak I, Bartsch DU, Cheng L, McCutchan A, Weinreb RN, Freeman WR. Scanning laser polarimetry demonstration of retinal nerve fiber layer damage in human immunodeficiency virus-positive patients without infectious retinitis. Retina. 2007 Nov-Dec; 27(9):1267-73. PMID: 18046236.
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    150. Kozak I, Robbins SL, Freeman WR. Bilateral papillitis associated with bilateral anterior uveitis in a child. J Pediatr Ophthalmol Strabismus. 2007 Nov-Dec; 44(6):374-6. PMID: 18062496.
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    151. Tammewar AM, Cheng L, Hostetler KY, Falkenstein I, Beadle JR, Barron EC, Kozak I, Freeman WR. Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig. J Ocul Pharmacol Ther. 2007 Oct; 23(5):433-44. PMID: 17900229.
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    152. Falkenstein IA, Cheng L, Freeman WR. Changes of intraocular pressure after intravitreal injection of bevacizumab (avastin). Retina. 2007 Oct; 27(8):1044-7. PMID: 18040242.
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    153. Falkenstein IA, Cochran DE, Azen SP, Dustin L, Tammewar AM, Kozak I, Freeman WR. Comparison of visual acuity in macular degeneration patients measured with snellen and early treatment diabetic retinopathy study charts. Ophthalmology. 2008 Feb; 115(2):319-23. PMID: 17706288; PMCID: PMC2709293.
    154. Falkenstein IA, Cheng L, Morrison VL, Kozak I, Tammewar AM, Freeman WR. Standardized visual acuity results associated with primary versus secondary bevacizumab (avastin) treatment for choroidal neovascularization in age-related macular degeneration. Retina. 2007 Jul-Aug; 27(6):701-6. PMID: 17621178; PMCID: PMC2752060.
    155. Koh HJ, Cheng L, Kosobucki B, Freeman WR. Prophylactic intraoperative 360 degrees laser retinopexy for prevention of retinal detachment. Retina. 2007 Jul-Aug; 27(6):744-9. PMID: 17621184.
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    156. Kozak I, Bartsch DU, Cheng L, Freeman WR. Hyperreflective sign in resolved cotton wool spots using high-resolution optical coherence tomography and optical coherence tomography ophthalmoscopy. Ophthalmology. 2007 Mar; 114(3):537-43. PMID: 17324696.
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    157. Kozak I, Cheng L, Falkenstein I, Tammewar AM, Freeman WR. Evaluation of subretinal triamcinolone acetonide in patients with exudative age-related macular degeneration. J Ocul Pharmacol Ther. 2007 Feb; 23(1):46-53. PMID: 17341150.
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    158. Morrison VL, Kozak I, LaBree LD, Azen SP, Kayicioglu OO, Freeman WR. Intravitreal triamcinolone acetonide for the treatment of immune recovery uveitis macular edema. Ophthalmology. 2007 Feb; 114(2):334-9. PMID: 17270681.
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    159. Kozak I, Sample PA, Hao J, Freeman WR, Weinreb RN, Lee TW, Goldbaum MH. Machine learning classifiers detect subtle field defects in eyes of HIV individuals. Trans Am Ophthalmol Soc. 2007; 105:111-8; discussion 119-20. PMID: 18427600; PMCID: PMC2258123.
    160. Bessho K, Schrier RD, Freeman WR. Immune recovery uveitis in a CMV retinitis patient without hiv infection. Retin Cases Brief Rep. 2007; 1(1):52-3. PMID: 25390240.
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    161. Kayikcioglu OR, Mendez T, Morrison V, Freeman WR. A new technique for the subretinal injection of small volumes by using a modified viscous fluid injector system. Retina. 2006 Nov-Dec; 26(9):1089-90. PMID: 16622393.
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    162. Falkenstein I, Kozak I, Kayikcioglu O, Cheng L, Bartsch DU, Azen SP, Labree LD, Freeman WR. Assessment of retinal function in patients with HIV without infectious retinitis by multifocal electroretinogram and automated perimetry. Retina. 2006 Oct; 26(8):928-34. PMID: 17031295.
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    163. Kozak I, Kayikcioglu OR, Cheng L, Falkenstein I, Silva GA, Yu DX, Freeman WR. The effect of recombinant human hyaluronidase on dexamethasone penetration into the posterior segment of the eye after sub-Tenon's injection. J Ocul Pharmacol Ther. 2006 Oct; 22(5):362-9. PMID: 17076631.
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    164. Freeman WR, Falkenstein I. Avastin and new treatments for AMD: where are we? Retina. 2006 Oct; 26(8):853-8. PMID: 17031283.
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    165. Kozak I, Cheng L, Mendez T, Davidson MC, Freeman WR. Evaluation of the toxicity of subretinal triamcinolone acetonide in the rabbit. Retina. 2006 Sep; 26(7):811-7. PMID: 16963856.
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    166. Kozak I, Dean A, Clark TM, Falkenstein I, Freeman WR. Prefilled syringe needles versus standard removable needles for intravitreous injection. Retina. 2006 Jul-Aug; 26(6):679-83. PMID: 16829812.
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    167. Kozak I, Bartsch DU, Cheng L, Freeman WR. In vivo histology of cotton-wool spots using high-resolution optical coherence tomography. Am J Ophthalmol. 2006 Apr; 141(4):748-50. PMID: 16564817.
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    168. Kempen JH, Min YI, Freeman WR, Holland GN, Friedberg DN, Dieterich DT, Jabs DA. Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis. Ophthalmology. 2006 Apr; 113(4):684-94. PMID: 16581429.
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    169. Kozak I, Freeman WR. Nonprogressive extrafoveal retinal hole after foveal epiretinal membrane removal. Am J Ophthalmol. 2006 Apr; 141(4):769-71. PMID: 16564828.
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    170. Friberg TR, Musch DC, Lim JI, Morse L, Freeman W, Sinclair S. Prophylactic treatment of age-related macular degeneration report number 1: 810-nanometer laser to eyes with drusen. Unilaterally eligible patients. Ophthalmology. 2006 Apr; 113(4):622.e1. PMID: 16581422.
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    171. Morrison VL, Koh HJ, Cheng L, Bessho K, Davidson MC, Freeman WR. Intravitreal toxicity of the kenalog vehicle (benzyl alcohol) in rabbits. Retina. 2006 Mar; 26(3):339-44. PMID: 16508436.
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    172. Kozak I, LaBree L, Azen SP, Cheng L, Reagan NL, Freeman WR. Long-term study of intraocular pressure changes in patients with human immunodeficiency virus treated with highly active antiretroviral therapy. Ophthalmology. 2006 Mar; 113(3):451-5. PMID: 16513459.
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    173. Kayikcioglu OR, Falkenstein I, Cheng L, Kozak I, La Bree L, Azen SP, Wong-Staal F, Paoni NF, Freeman WR. Therapy with ribozyme to the proliferating cell nuclear antigen-ribozyme and 5-fluorouracil of experimental choroidal neovascularization in rats. J Ocul Pharmacol Ther. 2006 Feb; 22(1):1-9. PMID: 16503769.
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    174. Schrier RD, Song MK, Smith IL, Karavellas MP, Bartsch DU, Torriani FJ, Garcia CR, Freeman WR. Intraocular viral and immune pathogenesis of immune recovery uveitis in patients with healed cytomegalovirus retinitis. Retina. 2006 Feb; 26(2):165-9. PMID: 16467672.
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    175. Koh HJ, Freeman WR, Azen SP, Flaxel CJ, Labree LD, Cheng L, Wills M, Jones TR. Effect of a novel octapeptide urokinase fragment, A6, on experimental choroidal neovascularization in the monkey. Retina. 2006 Feb; 26(2):202-9. PMID: 16467679.
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    176. Lai WW, Zhou YS, Lam DS, Freeman WR, Chow DR, Murray TG. Diagnostic and therapeutic challenges. Retina. 2006 Jan; 26(1):96-101. PMID: 16395146.
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    177. Bessho K, Rodanant N, Bartsch DU, Cheng L, Koh HJ, Freeman WR. Effect of subthreshold infrared laser treatment for drusen regression on macular autofluorescence in patients with age-related macular degeneration. Retina. 2005 Dec; 25(8):981-8. PMID: 16340527.
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    178. Kozak I, Cheng L, Freeman WR. Lidocaine gel anesthesia for intravitreal drug administration. Retina. 2005 Dec; 25(8):994-8. PMID: 16340529.
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    179. Morrison VL, Labree LD, Azen SP, Goldberg DE, Freeman WR. Results of silicone oil removal in patients with cytomegalovirus retinitis related retinal detachments. Am J Ophthalmol. 2005 Nov; 140(5):786-793. PMID: 16214100.
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    180. Freeman WR. Control of data, authorship, and responsibility for clinical trials publications. Ophthalmology. 2005 Sep; 112(9):1485-6. PMID: 16139664.
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    181. Goldberg DE, Smithen LM, Angelilli A, Freeman WR. HIV-associated retinopathy in the HAART era. Retina. 2005 Jul-Aug; 25(5):633-49; quiz 682-3. PMID: 16077362.
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    182. Kozak I, Bartsch DU, Cheng L, Kosobucki BR, Freeman WR. Objective analysis of retinal damage in HIV-positive patients in the HAART era using OCT. Am J Ophthalmol. 2005 Feb; 139(2):295-301. PMID: 15733991; PMCID: PMC3757251.
    183. Cheng L, Toyoguchi M, Looney DJ, Lee J, Davidson MC, Freeman WR. Efficient gene transfer to retinal pigment epithelium cells with long-term expression. Retina. 2005 Feb-Mar; 25(2):193-201. PMID: 15689811; PMCID: PMC1382166.
    184. Freeman WR, El-Bradey M, Plummer DJ. Scanning laser entoptic perimetry for the detection of age-related macular degeneration. Arch Ophthalmol. 2004 Nov; 122(11):1647-51. PMID: 15534125; PMCID: PMC1367991.
    185. Cheng L, Hostetler KY, Lee J, Koh HJ, Beadle JR, Bessho K, Toyoguchi M, Aldern K, Bovet JM, Freeman WR. Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4138-44. PMID: 15505067; PMCID: PMC2666013.
    186. Koh HJ, Cheng L, Bessho K, Jones TR, Davidson MC, Freeman WR. Intraocular properties of urokinase-derived antiangiogenic A6 peptide in rabbits. J Ocul Pharmacol Ther. 2004 Oct; 20(5):439-49. PMID: 15650519.
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    187. Tabandeh H, Smiddy WE, Sullivan PM, Monshizadeh R, Rafiei N, Cheng L, Freeman W. Characteristics and outcomes of choroidal neovascularization occurring after macular hole surgery. Retina. 2004 Oct; 24(5):714-20. PMID: 15492624.
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    188. El-Bradey MH, Cheng L, Bartsch DU, Niessman M, El-Musharaf A, Freeman WR. The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinase, on a new animal model of epiretinal membrane. Retina. 2004 Oct; 24(5):783-9. PMID: 15492635.
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    189. El-Bradey MH, Cheng L, Song MK, Torriani FJ, Freeman WR. Long-term results of treatment of macular complications in eyes with immune recovery uveitis using a graded treatment approach. Retina. 2004 Jun; 24(3):376-82. PMID: 15187659; PMCID: PMC1378115.
    190. El Bradey M, Cheng L, Bartsch DU, Appelt K, Rodanant N, Bergeron-Lynn G, Freeman WR. Preventive versus treatment effect of AG3340, a potent matrix metalloproteinase inhibitor in a rat model of choroidal neovascularization. J Ocul Pharmacol Ther. 2004 Jun; 20(3):217-36. PMID: 15279727; PMCID: PMC1360230.
    191. Kosobucki BR, Goldberg DE, Bessho K, Koh HJ, Rodanant N, Labree L, Cheng L, Schrier RD, Azen SP, Freeman WR. Valganciclovir therapy for immune recovery uveitis complicated by macular edema. Am J Ophthalmol. 2004 Apr; 137(4):636-8. PMID: 15059701.
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    192. Freeman WR, McCutchan JA, Arevalo JF, Wolfson T, Marcotte TD, Heaton RK, Grant I. The relationship between AIDS retinal cotton wool spots and neuropsychological impairment in HIV-positive individuals in the pre-highly active antiretroviral therapy era. Ocul Immunol Inflamm. 2004 Mar; 12(1):25-33. PMID: 15209461; PMCID: PMC1378132.
    193. Koh HJ, Bessho K, Cheng L, Bartsch DU, Jones TR, Bergeron-Lynn G, Freeman WR. Inhibition of choroidal neovascularization in rats by the urokinase-derived peptide A6. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):635-40. PMID: 14744908; PMCID: PMC1378117.
    194. Song MK, Azen SP, Buley A, Torriani F, Cheng L, Chaidhawangul S, Ozerdem U, Scholz B, Freeman WR. Effect of anti-cytomegalovirus therapy on the incidence of immune recovery uveitis in AIDS patients with healed cytomegalovirus retinitis. Am J Ophthalmol. 2003 Oct; 136(4):696-702. PMID: 14516810.
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    195. Bartsch DU, Aurora A, Rodanant N, Cheng L, Freeman WR. Volumetric analysis of macular edema by scanning laser tomography in immune recovery uveitis. Arch Ophthalmol. 2003 Sep; 121(9):1246-51. PMID: 12963607.
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    196. Rodanant N, Bartsch DU, Bessho K, Freeman WR. Autofluorescence image in ocular albinism. Retina. 2003 Apr; 23(2):265-6. PMID: 12707618.
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    197. Cheng L, Hostetler KY, Toyoguchi M, Beadle JR, Rodanant N, Gardner MF, Aldern KA, Bergeron-Lynn G, Freeman WR. Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir. J Ocul Pharmacol Ther. 2003 Apr; 19(2):161-9. PMID: 12804061.
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    198. Bartsch DU, Elmusharaf A, El-Bradey M, Freeman WR. Oral fluorescein angiography in patients with choroidal neovascularization and macular degeneration. Ophthalmic Surg Lasers Imaging. 2003 Jan-Feb; 34(1):17-24. PMID: 12570000.
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    199. Blanchard JN, Powell HC, Freeman WR, Letendre S, Blanchard D, Shimizu C, Burns JC. Recurrent Kawasaki disease-like syndrome in a patient with acquired immunodeficiency syndrome. Clin Infect Dis. 2003 Jan 01; 36(1):105-11. PMID: 12491210.
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    200. Mueller AJ, Freeman WR, Schaller UC, Kampik A, Folberg R. Complex microcirculation patterns detected by confocal indocyanine green angiography predict time to growth of small choroidal melanocytic tumors: MuSIC Report II. Ophthalmology. 2002 Dec; 109(12):2207-14. PMID: 12466160.
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    201. Seaberg RR, Freeman WR, Goldbaum MH, Manecke GR. Permanent postoperative vision loss associated with expansion of intraocular gas in the presence of a nitrous oxide-containing anesthetic. Anesthesiology. 2002 Nov; 97(5):1309-10. PMID: 12411820.
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    202. Rodanant N, Friberg TR, Cheng L, Aurora A, Bartsch D, Toyoguchi M, Corbin PS, El-Bradey MH, Freeman WR. Predictors of drusen reduction after subthreshold infrared (810 nm) diode laser macular grid photocoagulation for nonexudative age-related macular degeneration. Am J Ophthalmol. 2002 Oct; 134(4):577-85. PMID: 12383815.
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    203. Mueller AJ, Maniotis AJ, Freeman WR, Bartsch DU, Schaller UC, Bergeron-Lynn G, Cheng L, Taskintuna I, Chen X, Kan-Mitchell J, Folberg R. An orthotopic model for human uveal melanoma in SCID mice. Microvasc Res. 2002 Sep; 64(2):207-13. PMID: 12204644.
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    204. Goldberg DE, Freeman WR. Uveitic angle closure glaucoma in a patient with inactive cytomegalovirus retinitis and immune recovery uveitis. Ophthalmic Surg Lasers. 2002 Sep-Oct; 33(5):421-5. PMID: 12358297.
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    205. Cheng L, Azen SP, El-Bradey MH, Toyoguchi M, Chaidhawangul S, Rivero ME, Scholz BM, Freeman WR. Effects of preoperative and postoperative epiretinal membranes on macular hole closure and visual restoration. Ophthalmology. 2002 Aug; 109(8):1514-20. PMID: 12153804.
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    206. Bartsch DU, Zhu L, Sun PC, Fainman S, Freeman WR. Retinal imaging with a low-cost micromachined membrane deformable mirror. J Biomed Opt. 2002 Jul; 7(3):451-6. PMID: 12175296.
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    207. Song MK, Schrier RD, Smith IL, Plummer DJ, Freeman WR. Paradoxical activity of CMV retinitis in patients receiving highly active antiretroviral therapy. Retina. 2002 Jun; 22(3):262-7. PMID: 12055457.
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    208. Bartsch DU, Freeman WR, Lopez AM. A false use of "true color". Arch Ophthalmol. 2002 May; 120(5):675-6; author reply 676. PMID: 12003634.
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    209. Rodanant N, Thompson C, Freeman WR. A compact, inexpensive face-down positioning device. Retina. 2002 Apr; 22(2):242-4. PMID: 11927869.
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    210. Cheng L, Chaidhawangul S, Wong-Staal F, Gilbert J, Poeschla E, Toyoguchi M, El-Bradey M, Bergeron-Lynn G, Soules KA, Freeman WR. Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res. 2002 Mar; 24(3):196-201. PMID: 12221527.
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    211. Ozerdem U, Mach-Hofacre B, Varki N, Folberg R, Mueller AJ, Ochabski R, Pham T, Appelt K, Freeman WR. The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on uveal melanoma rabbit model. Curr Eye Res. 2002 Feb; 24(2):86-91. PMID: 12187478.
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    212. Cheng L, Hostetler KY, Chaidhawangul S, Gardner MF, Beadle JR, Toyoguchi M, Bergeron-Lynn G, Freeman WR. Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):515-21. PMID: 11818399.
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    213. Garcia C, Bartsch DU, Rivero ME, Hagedorn M, McDermott CD, Bergeron-Lynn G, Cheng L, Appelt K, Freeman WR. Efficacy of Prinomastat) (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization. Curr Eye Res. 2002 Jan; 24(1):33-8. PMID: 12187492.
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