Celsa Spina

Title(s)Associate Adjunct Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Use of Protein Biomarkers to Identify Latent/Persistent HIV Infected Cell Reservoirs Without Induced Reactivation
    NIH R21AI122389Aug 15, 2016 - Jan 31, 2019
    Role: Principal Investigator
    Synthetic Molecular Sensors to Target Latently Infected Cells for HIV Eradication
    NIH R33AI104282Feb 1, 2013 - Jun 30, 2020
    Role: Principal Investigator
    Control of Latent/Persistent HIV Infection in Primary CD4 T Cells
    NIH I01BX001160Jul 1, 2011 - Jun 30, 2015
    Role: Principal Investigator
    MoFlo XDP High Speed Cell Sorter
    NIH S10RR027933May 20, 2010 - May 19, 2011
    Role: Principal Investigator
    Global Gene Regulation in CD4 T Cell Signaling
    NIH R21AI055388Apr 15, 2003 - Mar 31, 2006
    Role: Principal Investigator
    LYMPHOCYTE RESPONSE AND REGULATION IN HERPES INFECTION
    NIH R23AI019952Jun 1, 1983 - Jul 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Micro RNA Targets in HIV Latency: Insights into Novel Layers of Latency Control. AIDS Res Hum Retroviruses. 2021 02; 37(2):109-121. Heinson AI, Woo J, Mukim A, White CH, Moesker B, Bosque A, Spina CA, Woelk CH, Macarthur BD, Beliakova-Bethell N. PMID: 33045840.
      View in: PubMed   Mentions: 1     Fields:    
    2. Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal. PLoS One. 2019; 14(11):e0224879. Trypsteen W, White CH, Mukim A, Spina CA, De Spiegelaere W, Lefever S, Planelles V, Bosque A, Woelk CH, Vandekerckhove L, Beliakova-Bethell N. PMID: 31710657.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    3. Subclinical Cytomegalovirus DNA Is Associated with CD4 T Cell Activation and Impaired CD8 T Cell CD107a Expression in People Living with HIV despite Early Antiretroviral Therapy. J Virol. 2019 07 01; 93(13). Christensen-Quick A, Massanella M, Frick A, Rawlings SA, Spina C, Vargas-Meneses M, Schrier R, Nakazawa M, Anderson C, Gianella S. PMID: 31019052.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    4. Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation. J Biol Chem. 2019 04 05; 294(14):5576-5589. Beliakova-Bethell N, Mukim A, White CH, Deshmukh S, Abewe H, Richman DD, Spina CA. PMID: 30745362.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    5. Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment. Front Immunol. 2018; 9:603. White CH, Beliakova-Bethell N, Lada SM, Breen MS, Hurst TP, Spina CA, Richman DD, Frater J, Magiorkinis G, Woelk CH. PMID: 29706951.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 08; 508:127-133. Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA. PMID: 28527342.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    7. HIV viral kinetics and T cell dynamics in antiretroviral naïve persons starting an integrase strand transfer inhibitor and protease inhibitor regimen. HIV Clin Trials. 2017 03; 18(2):67-74. Karris MY, Jain S, Day TR, Pérez-Santiago J, Goicoechea M, Dubé MP, Sun X, Spina C, Daar ES, Haubrich RH, Morris S, California Collaborative Treatment Group (CCTG) 589 Study Team . PMID: 28134057.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    8. Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. PLoS Pathog. 2016 Nov; 12(11):e1006026. White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina CA, Margolis DM, Richman DD, Planelles V, Bosque A, Woelk CH. PMID: 27898737.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    9. Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART. . 2016 06 01; 72(2):133-7. Dan JM, Massanella M, Smith DM, Spina CA, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S. PMID: 26818740.
      View in: PubMed   Mentions:
    10. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015 Dec 16; 90(5):2486-502. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina CA, Guatelli J. PMID: 26676780.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. AIDS. 2015 Nov; 29(17):2235-44. Reardon B, Beliakova-Bethell N, Spina CA, Singhania A, Margolis DM, Richman DR, Woelk CH. PMID: 26258524.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Res. 2015 Nov; 123:78-85. White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman DD, Spina CA, Garbis SD, Woelk CH, Beliakova-Bethell N. PMID: 26343910.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    13. Cerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND). PLoS One. 2015; 10(2):e0116526. Schrier RD, Hong S, Crescini M, Ellis R, Pérez-Santiago J, Spina C, Letendre S, HNRP Group . PMID: 25719800.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    14. Sulfonation pathway inhibitors block reactivation of latent HIV-1. Virology. 2014 Dec; 471-473:1-12. Murry JP, Godoy J, Mukim A, Swann J, Bruce JW, Ahlquist P, Bosque A, Planelles V, Spina CA, Young JA. PMID: 25310595.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment. J Virol. 2014 Jul; 88(14):7818-27. Gianella S, Massanella M, Richman DD, Little SJ, Spina CA, Vargas MV, Lada SM, Daar ES, Dube MP, Haubrich RH, Morris SR, Smith DM, California Collaborative Treatment Group 592 Team . PMID: 24789781.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    16. Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression. Antiviral Res. 2014 Jul; 107:42-9. Beliakova-Bethell N, Jain S, Woelk CH, Witt MD, Sun X, Lada SM, Spina CA, Goicoechea M, Rought SE, Haubrich R, Dubé MP. PMID: 24769244.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog. 2014 Apr; 10(4):e1004071. Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry JP, Stepan G, Stray KM, Tsai A, Yu H, Spindler J, Kearney M, Spina CA, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T. PMID: 24722454.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansCellsCTClinical Trials
    18. Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. AIDS. 2014 Mar 27; 28(6):841-9. Karris MY, Kao YT, Patel D, Dawson M, Woods SP, Vaida F, Spina C, Richman D, Little S, Smith DM. PMID: 24401640.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog. 2013; 9(12):e1003834. Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. PMID: 24385908.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansCells
    20. The effect of cell subset isolation method on gene expression in leukocytes. Cytometry A. 2014 Jan; 85(1):94-104. Beliakova-Bethell N, Massanella M, White C, Lada S, Du P, Vaida F, Blanco J, Spina CA, Woelk CH. PMID: 24115734.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    21. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013 Jul 31; 27(12):1921-31. Pérez-Santiago J, Gianella S, Massanella M, Spina CA, Karris MY, Var SR, Patel D, Jordan PS, Young JA, Little SJ, Richman DD, Smith DM. PMID: 24180001.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    22. Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One. 2013; 8(4):e55943. Strain MC, Lada SM, Luong T, Rought SE, Gianella S, Terry VH, Spina CA, Woelk CH, Richman DD. PMID: 23573183.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansCells
    23. Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS. 2013 Jan 02; 27(1):29-37. Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman DD, Spina CA, Woelk CH. PMID: 23221426.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    24. Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. AIDS. 2013 Jan 02; 27(1):39-47. Gianella S, Morris SR, Anderson C, Spina CA, Vargas MV, Young JA, Richman DD, Little SJ, Smith DM. PMID: 22739399.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    25. Increased toll-like receptor signaling pathways characterize CD8+ cells in rapidly progressive SIV infection. Biomed Res Int. 2013; 2013:796014. Marcondes MC, Spina C, Bustamante E, Fox H. PMID: 23484159.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab Chip. 2012 Nov 07; 12(21):4305-12. Razooky BS, Gutierrez E, Terry VH, Spina CA, Groisman A, Weinberger LS. PMID: 22976503.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med (Berl). 2013 Feb; 91(2):261-70. Soto PC, Karris MY, Spina CA, Richman DD, Varki A. PMID: 22945238.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. Associations between virologic and immunologic dynamics in blood and in the male genital tract. J Virol. 2012 Feb; 86(3):1307-15. Gianella S, Strain MC, Rought SE, Vargas MV, Little SJ, Richman DD, Spina CA, Smith DM. PMID: 22114342.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    29. Flow cytometric screening for anti-leishmanials in a human macrophage cell line. Exp Parasitol. 2010 Dec; 126(4):617-20. Mehta SR, Zhang XQ, Badaro R, Spina C, Day J, Chang KP, Schooley RT. PMID: 20540940.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    30. Prevalence and T-cell phenotype of slow HIV disease progressors with robust HIV replication. . 2009 Oct 01; 52(2):299-301. Goicoechea M, Smith D, May S, Mathews C, Spina C. PMID: 20118679.
      View in: PubMed   Mentions:
    31. CD44 microbeads accelerate HIV-1 infection in T cells. Virology. 2009 Jun 05; 388(2):294-304. Terry VH, Johnston IC, Spina CA. PMID: 19394995.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. J Infect Dis. 2008 Feb 01; 197(3):411-9. Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, Spina CA, Richman DD, Wong JK. PMID: 18248304.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    33. Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clin Vaccine Immunol. 2006 Nov; 13(11):1223-30. Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS. PMID: 16988005.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    34. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines. J Virol. 2006 Feb; 80(4):1762-72. Stone GW, Barzee S, Snarsky V, Kee K, Spina CA, Yu XF, Kornbluth RS. PMID: 16439533.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    35. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet. 2005 Aug 13-19; 366(9485):549-55. Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM. PMID: 16099290.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansCells
    36. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J Infect Dis. 2005 May 01; 191(9):1410-8. Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina CA, Richman DD, Wong JK. PMID: 15809898.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansCells
    37. HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med. 2004 Dec 20; 200(12):1547-57. Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, Jones EY, Rowland-Jones SL. PMID: 15596521.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    38. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004 Feb; 2(2):E20. Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, Dong T, Chesney G, Waters A, Easterbrook P, Dunbar PR, Shepherd D, Cerundolo V, Emery V, Griffiths P, Conlon C, McMichael AJ, Richman DD, Rowland-Jones SL, Appay V. PMID: 14966528.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    39. Dynamics of T cell responses in HIV infection. J Immunol. 2002 Apr 01; 168(7):3660-6. Appay V, Papagno L, Spina CA, Hansasuta P, King A, Jones L, Ogg GS, Little S, McMichael AJ, Richman DD, Rowland-Jones SL. PMID: 11907132.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    40. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002 Apr; 8(4):379-85. Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, Ogg GS, King A, Lechner F, Spina CA, Little S, Havlir DV, Richman DD, Gruener N, Pape G, Waters A, Easterbrook P, Salio M, Cerundolo V, McMichael AJ, Rowland-Jones SL. PMID: 11927944.
      View in: PubMed   Mentions: 509     Fields:    Translation:HumansCells
    41. Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression. AIDS. 2002 Jan 25; 16(2):161-70. Appay V, Hansasuta P, Sutton J, Schrier RD, Wong JK, Furtado M, Havlir DV, Wolinsky SM, McMichael AJ, Richman DD, Rowland-Jones SL, Spina CA. PMID: 11807299.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    42. Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. J Clin Invest. 1997 Apr 01; 99(7):1774-85. Spina CA, Prince HE, Richman DD. PMID: 9120023.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
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