Celsa Spina

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0679
La Jolla CA 92093
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    Collapse Research 
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    Use of Protein Biomarkers to Identify Latent/Persistent HIV Infected Cell Reservoirs Without Induced Reactivation
    NIH/NIAID R21AI122389Aug 15, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Synthetic Molecular Sensors to Target Latently Infected Cells for HIV Eradication
    NIH/NIAID R33AI104282Feb 1, 2013 - Jun 30, 2019
    Role: Principal Investigator
    Control of Latent/Persistent HIV Infection in Primary CD4 T Cells
    VA I01BX001160Jul 1, 2011 - Jun 30, 2015
    Role: Principal Investigator
    MoFlo XDP High Speed Cell Sorter
    NIH/NCRR S10RR027933May 20, 2010 - May 19, 2011
    Role: Principal Investigator
    Global Gene Regulation in CD4 T Cell Signaling
    NIH/NIAID R21AI055388Apr 15, 2003 - Mar 31, 2006
    Role: Principal Investigator
    NIH/NIAID R23AI019952Jun 1, 1983 - Jul 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. White CH, Beliakova-Bethell N, Lada SM, Breen MS, Hurst TP, Spina C, Richman DD, Frater J, Magiorkinis G, Woelk CH. Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment. Front Immunol. 2018; 9:603. PMID: 29706951.
      View in: PubMed
    2. Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina C. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 08; 508:127-133. PMID: 28527342.
      View in: PubMed
    3. Karris MY, Jain S, Day TR, Pérez-Santiago J, Goicoechea M, Dubé MP, Sun X, Spina C, Daar ES, Haubrich RH, Morris S. HIV viral kinetics and T cell dynamics in antiretroviral naïve persons starting an integrase strand transfer inhibitor and protease inhibitor regimen. HIV Clin Trials. 2017 03; 18(2):67-74. PMID: 28134057.
      View in: PubMed
    4. White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina C, Margolis DM, Richman DD, Planelles V, Bosque A, Woelk CH. Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. PLoS Pathog. 2016 Nov; 12(11):e1006026. PMID: 27898737.
      View in: PubMed
    5. Dan JM, Massanella M, Smith DM, Spina C, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S. Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART. J Acquir Immune Defic Syndr. 2016 06 01; 72(2):133-7. PMID: 26818740.
      View in: PubMed
    6. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina C, Guatelli J. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015 Dec 16; 90(5):2486-502. PMID: 26676780; PMCID: PMC4810708.
    7. Reardon B, Beliakova-Bethell N, Spina C, Singhania A, Margolis DM, Richman DR, Woelk CH. Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. AIDS. 2015 Nov; 29(17):2235-44. PMID: 26258524; PMCID: PMC4917679 [Available on 11/01/16].
    8. White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman DD, Spina C, Garbis SD, Woelk CH, Beliakova-Bethell N. Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Res. 2015 Nov; 123:78-85. PMID: 26343910.
      View in: PubMed
    9. Schrier RD, Hong S, Crescini M, Ellis R, Pérez-Santiago J, Spina C, Letendre S. Cerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND). PLoS One. 2015; 10(2):e0116526. PMID: 25719800.
      View in: PubMed
    10. Murry JP, Godoy J, Mukim A, Swann J, Bruce JW, Ahlquist P, Bosque A, Planelles V, Spina C, Young JA. Sulfonation pathway inhibitors block reactivation of latent HIV-1. Virology. 2014 Dec; 471-473:1-12. PMID: 25310595; PMCID: PMC4392775.
    11. Gianella S, Massanella M, Richman DD, Little SJ, Spina C, Vargas MV, Lada SM, Daar ES, Dube MP, Haubrich RH, Morris SR, Smith DM. Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment. J Virol. 2014 Jul; 88(14):7818-27. PMID: 24789781; PMCID: PMC4097769.
    12. Beliakova-Bethell N, Jain S, Woelk CH, Witt MD, Sun X, Lada SM, Spina C, Goicoechea M, Rought SE, Haubrich R, Dubé MP. Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression. Antiviral Res. 2014 Jul; 107:42-9. PMID: 24769244; PMCID: PMC4116489.
    13. Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry JP, Stepan G, Stray KM, Tsai A, Yu H, Spindler J, Kearney M, Spina C, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog. 2014 Apr; 10(4):e1004071. PMID: 24722454; PMCID: PMC3983056.
    14. Karris MY, Kao YT, Patel D, Dawson M, Woods SP, Vaida F, Spina C, Richman D, Little S, Smith DM. Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. AIDS. 2014 Mar 27; 28(6):841-9. PMID: 24401640; PMCID: PMC4049563.
    15. Spina C, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog. 2013; 9(12):e1003834. PMID: 24385908; PMCID: PMC3873446.
    16. Beliakova-Bethell N, Massanella M, White C, Lada S, Du P, Vaida F, Blanco J, Spina C, Woelk CH. The effect of cell subset isolation method on gene expression in leukocytes. Cytometry A. 2014 Jan; 85(1):94-104. PMID: 24115734; PMCID: PMC3975050.
    17. Pérez-Santiago J, Gianella S, Massanella M, Spina C, Karris MY, Var SR, Patel D, Jordan PS, Young JA, Little SJ, Richman DD, Smith DM. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013 Jul 31; 27(12):1921-31. PMID: 24180001; PMCID: PMC3816380.
    18. Strain MC, Lada SM, Luong T, Rought SE, Gianella S, Terry VH, Spina C, Woelk CH, Richman DD. Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One. 2013; 8(4):e55943. PMID: 23573183; PMCID: PMC3616050.
    19. Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman DD, Spina C, Woelk CH. Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS. 2013 Jan 02; 27(1):29-37. PMID: 23221426; PMCID: PMC3752851.
    20. Gianella S, Morris SR, Anderson C, Spina C, Vargas MV, Young JA, Richman DD, Little SJ, Smith DM. Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. AIDS. 2013 Jan 02; 27(1):39-47. PMID: 22739399; PMCID: PMC3769229.
    21. Marcondes MC, Spina C, Bustamante E, Fox H. Increased toll-like receptor signaling pathways characterize CD8+ cells in rapidly progressive SIV infection. Biomed Res Int. 2013; 2013:796014. PMID: 23484159; PMCID: PMC3591242.
    22. Razooky BS, Gutierrez E, Terry VH, Spina C, Groisman A, Weinberger LS. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab Chip. 2012 Nov 07; 12(21):4305-12. PMID: 22976503; PMCID: PMC3589574.
    23. Soto PC, Karris MY, Spina C, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med (Berl). 2013 Feb; 91(2):261-70. PMID: 22945238; PMCID: PMC3558668.
    24. Gianella S, Strain MC, Rought SE, Vargas MV, Little SJ, Richman DD, Spina C, Smith DM. Associations between virologic and immunologic dynamics in blood and in the male genital tract. J Virol. 2012 Feb; 86(3):1307-15. PMID: 22114342; PMCID: PMC3264378.
    25. Mehta SR, Zhang XQ, Badaro R, Spina C, Day J, Chang KP, Schooley RT. Flow cytometric screening for anti-leishmanials in a human macrophage cell line. Exp Parasitol. 2010 Dec; 126(4):617-20. PMID: 20540940; PMCID: PMC2939291.
    26. Goicoechea M, Smith D, May S, Mathews C, Spina C. Prevalence and T-cell phenotype of slow HIV disease progressors with robust HIV replication. J Acquir Immune Defic Syndr. 2009 Oct 01; 52(2):299-301. PMID: 20118679; PMCID: PMC2818087.
    27. Terry VH, Johnston IC, Spina C. CD44 microbeads accelerate HIV-1 infection in T cells. Virology. 2009 Jun 05; 388(2):294-304. PMID: 19394995; PMCID: PMC2699902.
    28. Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, Spina C, Richman DD, Wong JK. Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. J Infect Dis. 2008 Feb 01; 197(3):411-9. PMID: 18248304.
      View in: PubMed
    29. Stone GW, Barzee S, Snarsky V, Spina C, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS. Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clin Vaccine Immunol. 2006 Nov; 13(11):1223-30. PMID: 16988005; PMCID: PMC1656546.
    30. Stone GW, Barzee S, Snarsky V, Kee K, Spina C, Yu XF, Kornbluth RS. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines. J Virol. 2006 Feb; 80(4):1762-72. PMID: 16439533; PMCID: PMC1367159.
    31. Lehrman G, Hogue IB, Palmer S, Jennings C, Spina C, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet. 2005 Aug 13-19; 366(9485):549-55. PMID: 16099290; PMCID: PMC1894952.
    32. Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina C, Richman DD, Wong JK. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J Infect Dis. 2005 May 01; 191(9):1410-8. PMID: 15809898.
      View in: PubMed
    33. Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, Jones EY, Rowland-Jones SL. HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med. 2004 Dec 20; 200(12):1547-57. PMID: 15596521; PMCID: PMC2212004.
    34. Papagno L, Spina C, Marchant A, Salio M, Rufer N, Little S, Dong T, Chesney G, Waters A, Easterbrook P, Dunbar PR, Shepherd D, Cerundolo V, Emery V, Griffiths P, Conlon C, McMichael AJ, Richman DD, Rowland-Jones SL, Appay V. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004 Feb; 2(2):E20. PMID: 14966528; PMCID: PMC340937.
    35. Appay V, Papagno L, Spina C, Hansasuta P, King A, Jones L, Ogg GS, Little S, McMichael AJ, Richman DD, Rowland-Jones SL. Dynamics of T cell responses in HIV infection. J Immunol. 2002 Apr 01; 168(7):3660-6. PMID: 11907132.
      View in: PubMed
    36. Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, Ogg GS, King A, Lechner F, Spina C, Little S, Havlir DV, Richman DD, Gruener N, Pape G, Waters A, Easterbrook P, Salio M, Cerundolo V, McMichael AJ, Rowland-Jones SL. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002 Apr; 8(4):379-85. PMID: 11927944.
      View in: PubMed
    37. Appay V, Hansasuta P, Sutton J, Schrier RD, Wong JK, Furtado M, Havlir DV, Wolinsky SM, McMichael AJ, Richman DD, Rowland-Jones SL, Spina C. Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression. AIDS. 2002 Jan 25; 16(2):161-70. PMID: 11807299.
      View in: PubMed
    38. Spina C, Prince HE, Richman DD. Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. J Clin Invest. 1997 Apr 01; 99(7):1774-85. PMID: 9120023; PMCID: PMC507999.
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