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Adam Halberstadt

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolHealth Sciences
Phone619-471-0525
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    Collapse Biography 
    Collapse Education and Training
    University of California San DiegoPost-doc2012Psychopharmacology
    University of PittsburghPh.D.2006Neurobiology
    University of DelawareB.A.1998Biology, Psychology
    Collapse Awards and Honors
    NIDA2009  - 2012F32 NRSA post-doctoral fellowship
    NIDCD2004  - 2006Individual F31 NRSA predoctoral fellowship
    NIMH2014  - 2016K01 Career Development Award
    International Society for Serotonin Research2013  - 2020Associate Councilor
    Serotonin Club2008Travel Award
    American College of Neuropsychopharmacology2011Travel Award
    American College of Neuropsychopharmacology2018Associate Member

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The Next Generation of Hallucinogens: A New Class of Synthetic Psychoactive Drugs
    NIH/NIDA R01DA041336Feb 15, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Role of the prefrontal cortex in serotonergic modulation of interval timing
    NIH/NIMH K01MH100644Jan 9, 2014 - Dec 31, 2016
    Role: Principal Investigator
    Mechanisms of hallucinogen effects on exploratory behavior in rats and mice
    NIH/NIDA F32DA025412May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Raphe Nuclei Projections to Vestibular Nuclei
    NIH/NIDCD F31DC006772Jul 4, 2004 - Jul 3, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD. Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). Neuropharmacology. 2019 Nov 19; 107856. PMID: 31756337.
      View in: PubMed
    2. Poulie CBM, Jensen AA, Halberstadt A, Kristensen JL. Dark Classics in Chemical Neuroscience: NBOMes. ACS Chem Neurosci. 2019 Oct 28. PMID: 31657895.
      View in: PubMed
    3. Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Dowling G, Wallach J, Halberstadt AL. Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD). Drug Test Anal. 2019 Aug; 11(8):1122-1133. PMID: 31083768.
      View in: PubMed
    4. Wallach J, Colestock T, Agramunt J, Claydon MDB, Dybek M, Filemban N, Chatha M, Halberstadt AL, Brandt SD, Lodge D, Bortolotto ZA, Adejare A. Pharmacological characterizations of the 'legal high' fluorolintane and isomers. Eur J Pharmacol. 2019 Aug 15; 857:172427. PMID: 31152702.
      View in: PubMed
    5. Young JW, Geyer MA, Halberstadt AL, van Enkhuizen J, Minassian A, Khan A, Perry W, Eyler LT. Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT. Bipolar Disord. 2019 Apr 26. PMID: 31025493.
      View in: PubMed
    6. Halberstadt AL, Brandt SD, Walther D, Baumann MH. 2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and a2-adrenergic receptors. Psychopharmacology (Berl). 2019 Mar; 236(3):989-999. PMID: 30904940.
      View in: PubMed
    7. Halberstadt AL, Chatha M, Chapman SJ, Brandt SD. Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice. J Psychopharmacol. 2019 Mar; 33(3):406-414. PMID: 30789291.
      View in: PubMed
    8. Halberstadt AL, Klein LM, Chatha M, Valenzuela LB, Stratford A, Wallach J, Nichols DE, Brandt SD. Correction to: Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA). Psychopharmacology (Berl). 2019 02; 236(2):809. PMID: 30443792.
      View in: PubMed
    9. Halberstadt AL, van der Zee JVF, Chatha M, Geyer MA, Powell SB. Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen. Psychopharmacology (Berl). 2019 Feb; 236(2):821-830. PMID: 30448990.
      View in: PubMed
    10. Halberstadt AL, Chatha M, Stratford A, Grill M, Brandt SD. Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran ("FLY") and benzodifuran ("DragonFLY") analogs. Neuropharmacology. 2019 01; 144:368-376. PMID: 30385253.
      View in: PubMed
    11. Halberstadt AL, Klein LM, Chatha M, Valenzuela LB, Stratford A, Wallach J, Nichols DE, Brandt SD. Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA). Psychopharmacology (Berl). 2019 02; 236(2):799-808. PMID: 30298278.
      View in: PubMed
    12. Hussong AM, Langley HA, Thomas T, Coffman J, Halberstadt A, Costanzo P, Rothenberg WA. Measuring Gratitude in Children. J Posit Psychol. 2019; 14(5):563-575. PMID: 31467585.
      View in: PubMed
    13. Klein LM, Cozzi NV, Daley PF, Brandt SD, Halberstadt AL. Receptor binding profiles and behavioral pharmacology of ring-substituted N,N-diallyltryptamine analogs. Neuropharmacology. 2018 11; 142:231-239. PMID: 29499272.
      View in: PubMed
    14. Halberstadt AL, Geyer MA. Effect of Hallucinogens on Unconditioned Behavior. Curr Top Behav Neurosci. 2018; 36:159-199. PMID: 28224459.
      View in: PubMed
    15. Brandt SD, Kavanagh PV, Twamley B, Westphal F, Elliott SP, Wallach J, Stratford A, Klein LM, McCorvy JD, Nichols DE, Halberstadt AL. Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775). Drug Test Anal. 2018 Feb; 10(2):310-322. PMID: 28585392.
      View in: PubMed
    16. Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Stratford A, Nichols DE, Halberstadt AL. Return of the lysergamides. Part III: Analytical characterization of N6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD). Drug Test Anal. 2017 Oct; 9(10):1641-1649. PMID: 28342178.
      View in: PubMed
    17. Halberstadt AL. Hallucinogenic Drugs: A New Study Answers Old Questions about LSD. Curr Biol. 2017 02 20; 27(4):R156-R158. PMID: 28222297.
      View in: PubMed
    18. Halberstadt AL. Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens. Curr Top Behav Neurosci. 2017; 32:283-311. PMID: 28097528.
      View in: PubMed
    19. Cope ZA, Halberstadt AL, van Enkhuizen J, Flynn AD, Breier M, Swerdlow NR, Geyer MA, Young JW. Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges. Psychopharmacology (Berl). 2016 Oct; 233(19-20):3513-25. PMID: 27534540.
      View in: PubMed
    20. Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, Lodge D, Halberstadt AL, Brandt SD, Adejare A. Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues. PLoS One. 2016; 11(6):e0157021. PMID: 27314670.
      View in: PubMed
    21. Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Colestock T, Burrow TE, Chapman SJ, Stratford A, Nichols DE, Halberstadt AL. Return of the lysergamides. Part II: Analytical and behavioural characterization of N6 -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ). Drug Test Anal. 2017 Jan; 9(1):38-50. PMID: 27265891.
      View in: PubMed
    22. Halberstadt AL, Hyun J, Ruderman MA, Powell SB. Effects of the psychotomimetic benzomorphan N-allylnormetazocine (SKF 10,047) on prepulse inhibition of startle in mice. Pharmacol Biochem Behav. 2016 09; 148:69-75. PMID: 27236030.
      View in: PubMed
    23. Brandt SD, Kavanagh PV, Dowling G, Talbot B, Westphal F, Meyer MR, Maurer HH, Halberstadt AL. Analytical characterization of N,N-diallyltryptamine (DALT) and 16 ring-substituted derivatives. Drug Test Anal. 2017 Jan; 9(1):115-126. PMID: 27100373.
      View in: PubMed
    24. Manning EE, Halberstadt AL, van den Buuse M. BDNF-Deficient Mice Show Reduced Psychosis-Related Behaviors Following Chronic Methamphetamine. Int J Neuropsychopharmacol. 2016 Apr; 19(4). PMID: 26453694.
      View in: PubMed
    25. Halberstadt AL, Sindhunata IS, Scheffers K, Flynn AD, Sharp RF, Geyer MA, Young JW. Effect of 5-HT2A and 5-HT2C receptors on temporal discrimination by mice. Neuropharmacology. 2016 08; 107:364-375. PMID: 27020041.
      View in: PubMed
    26. Halberstadt AL. Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine. Pharmacol Biochem Behav. 2016 Apr; 143:1-10. PMID: 26780349.
      View in: PubMed
    27. Halberstadt AL, Slepak N, Hyun J, Buell MR, Powell SB. The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents. Psychopharmacology (Berl). 2016 Apr; 233(7):1215-25. PMID: 26758284.
      View in: PubMed
    28. Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Hoang K, Wallach J, Halberstadt AL. Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD). Drug Test Anal. 2016 Sep; 8(9):891-902. PMID: 26456305.
      View in: PubMed
    29. Nichols DE, Sassano MF, Halberstadt AL, Klein LM, Brandt SD, Elliott SP, Fiedler WJ. N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues. ACS Chem Neurosci. 2015 Jul 15; 6(7):1165-75. PMID: 25547199.
      View in: PubMed
    30. Halberstadt AL. Recent advances in the neuropsychopharmacology of serotonergic hallucinogens. Behav Brain Res. 2015 Jan 15; 277:99-120. PMID: 25036425.
      View in: PubMed
    31. Greer GR, Grob CS, Halberstadt AL. PTSD symptom reports of patients evaluated for the New Mexico Medical Cannabis Program. J Psychoactive Drugs. 2014 Jan-Mar; 46(1):73-7. PMID: 24830188.
      View in: PubMed
    32. van Enkhuizen J, Geyer MA, Halberstadt AL, Zhuang X, Young JW. Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder. J Affect Disord. 2014 Feb; 155:247-54. PMID: 24287168.
      View in: PubMed
    33. Halberstadt AL, Geyer MA. Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response. Neuropharmacology. 2014 Feb; 77:200-7. PMID: 24012658.
      View in: PubMed
    34. Adams WK, Halberstadt AL, van den Buuse M. Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses. Front Pharmacol. 2013; 4:109. PMID: 24009584.
      View in: PubMed
    35. Halberstadt AL, Geyer MA. Serotonergic hallucinogens as translational models relevant to schizophrenia. Int J Neuropsychopharmacol. 2013 Nov; 16(10):2165-80. PMID: 23942028.
      View in: PubMed
    36. Toth M, Gresack JE, Hauger RL, Halberstadt AL, Risbrough VB. The role of PKC signaling in CRF-induced modulation of startle. Psychopharmacology (Berl). 2013 Oct; 229(4):579-89. PMID: 23722830.
      View in: PubMed
    37. Halberstadt AL, Geyer MA. Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement. Psychopharmacology (Berl). 2013 Jun; 227(4):727-39. PMID: 23407781.
      View in: PubMed
    38. Halberstadt AL, Powell SB, Geyer MA. Role of the 5-HT2A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice. Neuropharmacology. 2013 Jul; 70:218-27. PMID: 23376711.
      View in: PubMed
    39. Amitai N, Weber M, Swerdlow NR, Sharp RF, Breier MR, Halberstadt AL, Young JW. A novel visuospatial priming task for rats with relevance to Tourette syndrome and modulation of dopamine levels. Neurosci Biobehav Rev. 2013 Jul; 37(6):1139-49. PMID: 23010529.
      View in: PubMed
    40. Tanaka S, Young JW, Halberstadt AL, Masten VL, Geyer MA. Four factors underlying mouse behavior in an open field. Behav Brain Res. 2012 Jul 15; 233(1):55-61. PMID: 22569582.
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    41. Halberstadt AL, Buell MR, Price DL, Geyer MA. Differences in the locomotor-activating effects of indirect serotonin agonists in habituated and non-habituated rats. Pharmacol Biochem Behav. 2012 Jul; 102(1):88-94. PMID: 22487771.
      View in: PubMed
    42. Halberstadt AL, Nichols DE, Geyer MA. Behavioral effects of a,a,ß,ß-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor. Psychopharmacology (Berl). 2012 Jun; 221(4):709-18. PMID: 22222861.
      View in: PubMed
    43. van den Buuse M, Ruimschotel E, Martin S, Risbrough VB, Halberstadt AL. Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia. Neuropharmacology. 2011 Jul-Aug; 61(1-2):209-16. PMID: 21501627.
      View in: PubMed
    44. Halberstadt AL, Geyer MA. Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens. Neuropharmacology. 2011 Sep; 61(3):364-81. PMID: 21256140.
      View in: PubMed
    45. Halberstadt AL, Lehmann-Masten VD, Geyer MA, Powell SB. Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice. Psychopharmacology (Berl). 2011 May; 215(1):81-92. PMID: 21153406.
      View in: PubMed
    46. Halberstadt AL, Koedood L, Powell SB, Geyer MA. Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J Psychopharmacol. 2011 Nov; 25(11):1548-61. PMID: 21148021.
      View in: PubMed
    47. Grob CS, Danforth AL, Chopra GS, Hagerty M, McKay CR, Halberstadt AL, Greer GR. Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry. 2011 Jan; 68(1):71-8. PMID: 20819978.
      View in: PubMed
    48. Halberstadt AL, Nichols DE.(Muller CP, Jacobs B Eds.), Handbook of the Behavioral Neurobiology of Serotonin. Serotonin and serotonin receptors in hallucinogen action. 2010; 585-620.
    49. Quednow BB, Geyer MA, Halberstadt AL .. (Muller CP, Jacobs B Eds.), Handbook of the Behavioral Neurobiology of Serotonin. Serotonin and schizophrenia. 2010; 621-636.
    50. Halberstadt AL, Geyer MA. LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor. Psychopharmacology (Berl). 2010 Feb; 208(2):179-89. PMID: 19937319.
      View in: PubMed
    51. Halberstadt AL, van der Heijden I, Ruderman MA, Risbrough VB, Gingrich JA, Geyer MA, Powell SB. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul; 34(8):1958-67. PMID: 19322172.
      View in: PubMed
    52. Halberstadt AL, Geyer MA. Habituation and sensitization of acoustic startle: opposite influences of dopamine D1 and D2-family receptors. Neurobiol Learn Mem. 2009 Sep; 92(2):243-8. PMID: 18644244.
      View in: PubMed
    53. Halberstadt AL, Buell MR, Masten VL, Risbrough VB, Geyer MA. Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors. Psychopharmacology (Berl). 2008 Nov; 201(1):55-66. PMID: 18604652.
      View in: PubMed
    54. Cuccurazzu B, Halberstadt AL. Projections from the vestibular nuclei and nucleus prepositus hypoglossi to dorsal raphe nucleus in rats. Neurosci Lett. 2008 Jul 04; 439(1):70-4. PMID: 18511198.
      View in: PubMed
    55. Halberstadt AL, Balaban CD. Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala. J Chem Neuroanat. 2008 Jul; 35(4):317-25. PMID: 18434087.
      View in: PubMed
    56. Halberstadt AL, Balaban CD. Selective anterograde tracing of the individual serotonergic and nonserotonergic components of the dorsal raphe nucleus projection to the vestibular nuclei. Neuroscience. 2007 Jun 15; 147(1):207-23. PMID: 17507165.
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    57. Halberstadt AL, Balaban CD. Anterograde tracing of projections from the dorsal raphe nucleus to the vestibular nuclei. Neuroscience. 2006 Dec 01; 143(2):641-54. PMID: 16989955.
      View in: PubMed
    58. Halberstadt AL, Balaban CD. Serotonergic and nonserotonergic neurons in the dorsal raphe nucleus send collateralized projections to both the vestibular nuclei and the central amygdaloid nucleus. Neuroscience. 2006 Jul 07; 140(3):1067-77. PMID: 16600519.
      View in: PubMed
    59. Halberstadt AL, Balaban CD. Organization of projections from the raphe nuclei to the vestibular nuclei in rats. Neuroscience. 2003; 120(2):573-94. PMID: 12890525.
      View in: PubMed
    60. Halberstadt AL. The phencyclidine-glutamate model of schizophrenia. Clin Neuropharmacol. 1995 Jun; 18(3):237-49. PMID: 8635182.
      View in: PubMed