Christopher Schmickl

Title(s)	Assistant Clinical Professor, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
ORCID	0000-0001-5417-9980
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Biography

Education and Training

University Witten/Herdecke, Germany	MD/PhD	5/2012	MD 5/2012; Dr. med 9/2016 (formally recognized as PhD equivalent)
Harvard School of Public Health, Boston, MA	MPH	05/2013	Epidemiology/Biostatistics
Mayo Clinic, METRIC, Rochester, MN		05/2014	Post-doctoral Fellowship (Critical Care)
Boston University Medical Center, Boston, MA		06/2017	Internal Medicine Residency
Harvard Combined Program: Beth Israel Deaconess Medical Center/Massachusetts General Hospital, Boston, MA		06/2018	Sleep Medicine Fellowship
University of California, San Diego, CA		08/2021	T32-Postdoctoral Fellowship (Sleep Medicine)

ORNG Applications

Clinical Trials

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Pathogenesis of sleep-disordered breathing in the setting of opioid use: a multiple mediation analysis using physiology. Sleep. 2024 Nov 08; 47(11). Orr JE, Malhotra A, Gruenberg E, Marin T, Sands SA, Alex RM, Owens RL, Schmickl CN. PMID: 38605676.

View in: PubMed Mentions: 1 Fields:
Psy Psychophysiology
Translation:Humans
Combination Drug Therapy with Acetazolamide, Eszopiclone +/- Venlafaxine for Obstructive Sleep Apnea (RESCUE-Combo): A Randomized, Double-blind, Placebo-controlled Trial. Ann Am Thorac Soc. 2024 Nov 08. Schmickl CN, Orr JE, Alex RM, Gruenberg E, Parra G, White S, Spenceley A, DeSarkar T, Kong M, DeYoung PN, Sands SA, Owens RL, Malhotra A. PMID: 39514000.

View in: PubMed Mentions: Fields:
Pul Pulmonary Medicine
Endotypic Trait Differences in Class 2/3 Obese Patients with and without Obstructive Sleep Apnea: A Preliminary Analysis of Preoperative Bariatric Surgery Patients. Ann Am Thorac Soc. 2024 Nov; 21(11):1616-1619. Nokes B, Schmickl CN, Alex R, Grunvald E, Orr JE, Harding CD, Sands SA, Owens RL, Malhotra A. PMID: 39041883; PMCID: PMC11568511.

View in: PubMed Mentions: Fields:
Pul Pulmonary Medicine
Sleep, Sleep Apnea, and Fatigue in People Living With HIV. J Acquir Immune Defic Syndr. 2024 Oct 01; 97(2):192-201. Orr JE, Velazquez J, Schmickl CN, Bosompra NO, DeYoung PN, Gilbertson D, Malhotra A, Grant I, Ancoli-Israel S, Karris MY, Owens RL. PMID: 39250653.

View in: PubMed Mentions: Fields:
Acq Acquired Immunodeficiency Synd
Translation:Humans
The Impact of Obesity on Cardiorespiratory Fitness and Weight Changes in a Cardiac Rehabilitation Program. J Cardiopulm Rehabil Prev. 2024 Jul 01; 44(4):E9-E11. Mittal N, Sonners C, Raphelson J, Sykes A, Roberts E, Swiatkiewicz I, Taub PR, Malhotra A, Schmickl CN. PMID: 38836700; PMCID: PMC11222021.

View in: PubMed Mentions: Fields:
Car Cardiology Phy Physical and Rehabilitation Me Pul Pulmonary Medicine
Translation:Humans
Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort. J Appl Physiol (1985). 2024 Jun 01; 136(6):1516-1525. Nokes B, Orr JE, White S, Luu S, Chen Z, Alex R, Sands SA, Wojeck BS, Owens RL, Malhotra A, Schmickl CN. PMID: 38660729; PMCID: PMC11368527.

View in: PubMed Mentions: 2 Fields:
Phy Physiology
Translation:Humans
Treatment of Sleep Apnea and Reduction in Blood Pressure: The Role of Heart Rate Response and Hypoxic Burden. Hypertension. 2024 May; 81(5):1106-1114. Messineo L, Sands SA, Schmickl C, Labarca G, Hu WH, Esmaeili N, Vena D, Gell L, Calianese N, Malhotra A, Gottlieb DJ, Wellman A, Redline S, Azarbarzin A. PMID: 38506074; PMCID: PMC11056868.

View in: PubMed Mentions: 1 Fields:
Vas Vascular Diseases
Translation:Humans
Loop Gain as a Predictor of Blood Pressure Response in Patients Treated for Obstructive Sleep Apnea: Secondary Analysis of a Clinical Trial. Ann Am Thorac Soc. 2024 Feb; 21(2):296-307. Schmickl CN, Orr JE, Sands SA, Alex RM, Azarbarzin A, McGinnis L, White S, Mazzotti DR, Nokes B, Owens RL, Gottlieb DJ, Malhotra A. PMID: 37938917; PMCID: PMC10848904.

View in: PubMed Mentions: 3 Fields:
Pul Pulmonary Medicine
Translation:Humans
Effectiveness of long-term noninvasive ventilation measured by remote monitoring in neuromuscular disease. ERJ Open Res. 2023 Sep; 9(5). Orr JE, Chen K, Vaida F, Schmickl CN, Laverty CG, Ravits J, Lesser D, Bhattacharjee R, Malhotra A, Owens RL. PMID: 37753280; PMCID: PMC10518857.

View in: PubMed Mentions: 2
International Consensus Statement on Obstructive Sleep Apnea. Int Forum Allergy Rhinol. 2023 07; 13(7):1061-1482. Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, Cahali MB, Cai Y, Cao M, Capasso R, Caples SM, Chahine LM, Chang CP, Chang KW, Chaudhary N, Cheong CSJ, Chowdhuri S, Cistulli PA, Claman D, Collen J, Coughlin KC, Creamer J, Davis EM, Dupuy-McCauley KL, Durr ML, Dutt M, Ali ME, Elkassabany NM, Epstein LJ, Fiala JA, Freedman N, Gill K, Gillespie MB, Golisch L, Gooneratne N, Gottlieb DJ, Green KK, Gulati A, Gurubhagavatula I, Hayward N, Hoff PT, Hoffmann OMG, Holfinger SJ, Hsia J, Huntley C, Huoh KC, Huyett P, Inala S, Ishman SL, Jella TK, Jobanputra AM, Johnson AP, Junna MR, Kado JT, Kaffenberger TM, Kapur VK, Kezirian EJ, Khan M, Kirsch DB, Kominsky A, Kryger M, Krystal AD, Kushida CA, Kuzniar TJ, Lam DJ, Lettieri CJ, Lim DC, Lin HC, Liu SYC, MacKay SG, Magalang UJ, Malhotra A, Mansukhani MP, Maurer JT, May AM, Mitchell RB, Mokhlesi B, Mullins AE, Nada EM, Naik S, Nokes B, Olson MD, Pack AI, Pang EB, Pang KP, Patil SP, Van de Perck E, Piccirillo JF, Pien GW, Piper AJ, Plawecki A, Quigg M, Ravesloot MJL, Redline S, Rotenberg BW, Ryden A, Sarmiento KF, Sbeih F, Schell AE, Schmickl CN, Schotland HM, Schwab RJ, Seo J, Shah N, Shelgikar AV, Shochat I, Soose RJ, Steele TO, Stephens E, Stepnowsky C, Strohl KP, Sutherland K, Suurna MV, Thaler E, Thapa S, Vanderveken OM, de Vries N, Weaver EM, Weir ID, Wolfe LF, Woodson BT, Won CHJ, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu JL, Zeidler M, Rosen IM. PMID: 36068685; PMCID: PMC10359192.

View in: PubMed Mentions: 54 Fields:
All Allergy and Immunology Oto Otolaryngology
Translation:Humans
POINT:: Are OSA Phenotypes Clinically Useful? Yes. Chest. 2023 01; 163(1):25-28. Edwards BA, Jordan AS, Schmickl CN, Owens RL. PMID: 36628670.

View in: PubMed Mentions: 1 Fields:
Pul Pulmonary Medicine
Translation:Humans
Rebuttal From Dr Edwards et al. Chest. 2023 01; 163(1):32-33. Edwards BA, Jordan AS, Schmickl CN, Owens RL. PMID: 36628673.

View in: PubMed Mentions: Fields:
Pul Pulmonary Medicine
The Impact of Underlying Obstructive Sleep Apnea Treatment on Exercise Capacity in Patients With Pulmonary Hypertension Undergoing a Cardiac Rehabilitation Program. J Cardiopulm Rehabil Prev. 2023 05 01; 43(3):186-191. Sykes AV, Sonners C, Schmickl CN, Raphelson J, Swiatkiewicz I, Roberts E, Feldman E, Malhotra A, Taub PR. PMID: 36729594; PMCID: PMC10148900.

View in: PubMed Mentions: 2 Fields:
Car Cardiology Phy Physical and Rehabilitation Me Pul Pulmonary Medicine
Translation:Humans
The impact of obstructive sleep apnea on exercise capacity in a cardiac rehabilitation program. Sleep Breath. 2023 08; 27(4):1269-1277. Sonners C, Schmickl CN, Raphelson J, Sykes AV, Roberts EG, Swiatkiewicz I, Malhotra A, Taub PR. PMID: 36173506; PMCID: PMC10050218.

View in: PubMed Mentions: 2 Fields:
Psy Psychophysiology Pul Pulmonary Medicine
Translation:Humans
Diagnostic performance of screening tools for the detection of obstructive sleep apnea in people living with HIV. J Clin Sleep Med. 2022 07 01; 18(7):1797-1804. Schmickl CN, Bosompra NO, DeYoung PN, Gilbertson D, Orr JE, Malhotra A, Grant I, Ancoli-Israel S, Young MK, Owens RL. PMID: 35383569; PMCID: PMC9243280.

View in: PubMed Mentions: Fields:
Neu Neurology Psy Psychophysiology
Translation:Humans PHPublic Health
Drug Therapy for Obstructive Sleep Apnea: Are We There Yet? Am J Respir Crit Care Med. 2022 06 15; 205(12):1379-1381. Schmickl CN, Edwards BA, Malhotra A. PMID: 35320066; PMCID: PMC9875900.

View in: PubMed Mentions: 3 Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans
The impact of daytime transoral neuromuscular stimulation on upper airway physiology - A mechanistic clinical investigation. Physiol Rep. 2022 06; 10(12):e15360. Nokes B, Schmickl CN, Brena R, Bosompra NN, Gilbertson D, Sands SA, Bhattacharjee R, Mann DL, Owens RL, Malhotra A, Orr JE. PMID: 35748091; PMCID: PMC9226850.

View in: PubMed Mentions: 4 Fields:
Phy Physiology
Translation:Humans
Obesity Hypoventilation Syndrome and Postsurgical Outcomes in a Bariatric Surgery Cohort. Obes Surg. 2022 07; 32(7):1-7. Raphelson JR, Schmickl CN, Sonners C, Kreitinger K, Grunvald E, Horgan S, Malhotra A. PMID: 35538187; PMCID: PMC9276616.

View in: PubMed Mentions: 1 Fields:
Gen General Surgery Met Metabolism
Translation:Humans
Point-of-care prediction model of loop gain in patients with obstructive sleep apnea: development and validation. BMC Pulm Med. 2022 Apr 25; 22(1):158. Schmickl CN, Orr JE, Kim P, Nokes B, Sands S, Manoharan S, McGinnis L, Parra G, DeYoung P, Owens RL, Malhotra A. PMID: 35468829; PMCID: PMC9036750.

View in: PubMed Mentions: 3 Fields:
Pul Pulmonary Medicine
Translation:Humans
Pathogenesis of obstructive sleep apnea in people living with HIV. J Appl Physiol (1985). 2021 12 01; 131(6):1671-1678. Orr JE, Edwards BA, Schmickl CN, Karris M, DeYoung PN, Darquenne C, Theilmann R, Jain S, Malhotra A, Hicks CB, Owens RL. PMID: 34672765; PMCID: PMC8714978.

View in: PubMed Mentions: 5 Fields:
Phy Physiology
Translation:Humans
Effects of acetazolamide on control of breathing in sleep apnea patients: Mechanistic insights using meta-analyses and physiological model simulations. Physiol Rep. 2021 10; 9(20):e15071. Schmickl CN, Landry S, Orr JE, Nokes B, Edwards BA, Malhotra A, Owens RL. PMID: 34699135; PMCID: PMC8547551.

View in: PubMed Mentions: 11 Fields:
Phy Physiology
Translation:Humans
Silent hypoxaemia in COVID-19 patients. J Physiol. 2021 02; 599(4):1057-1065. Simonson TS, Baker TL, Banzett RB, Bishop T, Dempsey JA, Feldman JL, Guyenet PG, Hodson EJ, Mitchell GS, Moya EA, Nokes BT, Orr JE, Owens RL, Poulin M, Rawling JM, Schmickl CN, Watters JJ, Younes M, Malhotra A. PMID: 33347610; PMCID: PMC7902403.

View in: PubMed Mentions: 47 Fields:
Phy Physiology
Translation:Humans Cells
ATS Core Curriculum 2020. Adult Sleep Medicine. ATS Sch. 2020 Dec 30; 1(4):476-494. Jamil SM, Owens RL, Lipford MC, Shafazand S, Marron RM, Vega Sanchez ME, Lam MT, Sunwoo BY, Schmickl C, Orr JE, Sharma S, Sankari A, Javaheri S, Bertisch S, Dupuy-McCauley K, Kolla B, Imayama I, Prasad B, Guzman E, Hayes MM, Wang T. PMID: 33870314; PMCID: PMC8015760.

View in: PubMed Mentions:
The Arousal Threshold as a Drug Target to Improve Continuous Positive Airway Pressure Adherence: Secondary Analysis of a Randomized Trial. Am J Respir Crit Care Med. 2020 12 01; 202(11):1592-1595. Schmickl CN, Lettieri CJ, Orr JE, DeYoung P, Edwards BA, Owens RL, Malhotra A. PMID: 32673496; PMCID: PMC7706152.

View in: PubMed Mentions: 12 Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans
Screening for Obstructive Sleep Apnea in a Diverse Bariatric Surgery Population. Obesity (Silver Spring). 2020 11; 28(11):2028-2034. Kreitinger KY, Lui MMS, Owens RL, Schmickl CN, Grunvald E, Horgan S, Raphelson JR, Malhotra A. PMID: 33150742; PMCID: PMC7760780.

View in: PubMed Mentions: 8 Fields:
Met Metabolism Nut Nutritional Sciences Phy Physiology
Translation:Humans PHPublic Health
Acetazolamide for OSA and Central Sleep Apnea: A Comprehensive Systematic Review and Meta-Analysis. Chest. 2020 12; 158(6):2632-2645. Schmickl CN, Landry SA, Orr JE, Chin K, Murase K, Verbraecken J, Javaheri S, Edwards BA, Owens RL, Malhotra A. PMID: 32768459; PMCID: PMC7768933.

View in: PubMed Mentions: 30 Fields:
Pul Pulmonary Medicine
Translation:Humans
Effect of Venlafaxine on Apnea-Hypopnea Index in Patients With Sleep Apnea: A Randomized, Double-Blind Crossover Study. Chest. 2020 08; 158(2):765-775. Schmickl CN, Li Y, Orr JE, Jen R, Sands SA, Edwards BA, DeYoung P, Owens RL, Malhotra A. PMID: 32278781; PMCID: PMC7417375.

View in: PubMed Mentions: 6 Fields:
Pul Pulmonary Medicine
Translation:Humans
Side effects of acetazolamide: a systematic review and meta-analysis assessing overall risk and dose dependence. BMJ Open Respir Res. 2020 04; 7(1). Schmickl CN, Owens RL, Orr JE, Edwards BA, Malhotra A. PMID: 32332024; PMCID: PMC7204833.

View in: PubMed Mentions: 32 Translation:Humans
Contemporary Concise Review 2019: Sleep and ventilation. Respirology. 2020 May; 25(5):552-558. Sunwoo BY, Schmickl CN, Malhotra A. PMID: 32048407; PMCID: PMC7162714.

View in: PubMed Mentions: 1 Fields:
Pul Pulmonary Medicine
Pathogenesis of obstructive sleep apnea in individuals with the COPD + OSA Overlap syndrome versus OSA alone. Physiol Rep. 2020 02; 8(3):e14371. Orr JE, Schmickl CN, Edwards BA, DeYoung PN, Brena R, Sun XS, Jain S, Malhotra A, Owens RL. PMID: 32061194; PMCID: PMC7023887.

View in: PubMed Mentions: 14 Fields:
Phy Physiology
Translation:Humans
Precision Medicine for Obstructive Sleep Apnea. Sleep Med Clin. 2019 Sep; 14(3):391-398. Light M, Owens RL, Schmickl CN, Malhotra A. PMID: 31375207; PMCID: PMC8931687.

View in: PubMed Mentions: 12 Fields:
Psy Psychophysiology
Translation:Humans
The Respiratory Signature: A Novel Concept to Leverage Continuous Positive Airway Pressure Therapy as an Early Warning System for Exacerbations of Common Diseases such as Heart Failure. J Clin Sleep Med. 2019 06 15; 15(6):923-927. Schmickl CN, Heckman E, Owens RL, Thomas RJ. PMID: 31138387; PMCID: PMC6557656.

View in: PubMed Mentions: 6 Fields:
Neu Neurology Psy Psychophysiology
Translation:Humans
Optimizing B-lines on lung ultrasound: an in-vitro to in-vivo pilot study with clinical implications. J Clin Monit Comput. 2020 Apr; 34(2):277-284. Schmickl CN, Menon AA, Dhokarh R, Seth B, Schembri F. PMID: 31089845; PMCID: PMC7429193.

View in: PubMed Mentions: 10 Fields:
Med Medical Informatics Med Medicine (General)
Translation:Humans
Prompting with electronic checklist improves clinician performance in medical emergencies: a high-fidelity simulation study. Int J Emerg Med. 2018 Apr 27; 11(1):26. Sevilla-Berrios R, O'Horo JC, Schmickl CN, Erdogan A, Chen X, Garcia Arguello LY, Dong Y, Kilickaya O, Pickering B, Kashyap R, Gajic O. PMID: 29704128; PMCID: PMC5924513.

View in: PubMed Mentions: 9
Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN): evolution of a content management system for point-of-care clinical decision support. BMC Med Inform Decis Mak. 2016 10 03; 16(1):127. Barwise A, Garcia-Arguello L, Dong Y, Hulyalkar M, Vukoja M, Schultz MJ, Adhikari NK, Bonneton B, Kilickaya O, Kashyap R, Gajic O, Schmickl CN. PMID: 27716243; PMCID: PMC5048402.

View in: PubMed Mentions: 6 Fields:
Med Medical Informatics
Translation:Humans
Development and validation of clinical performance assessment in simulated medical emergencies: an observational study. BMC Emerg Med. 2016 Jan 15; 16:4. Erdogan A, Dong Y, Chen X, Schmickl C, Sevilla Berrios RA, Garcia Arguello LY, Kashyap R, Kilickaya O, Pickering B, Gajic O, O'Horo JC. PMID: 26772732; PMCID: PMC4715281.

View in: PubMed Mentions: 8 Fields:
Eme Emergency Medicine
Translation:Humans
Response. Chest. 2015 Dec; 148(6):e194-e195. Schmickl CN, Biehl M, Wilson GA, Gajic O. PMID: 26621308.

View in: PubMed Mentions: Fields:
Pul Pulmonary Medicine
Translation:Humans
Comparison of hospital mortality and long-term survival in patients with acute lung injury/ARDS vs cardiogenic pulmonary edema. Chest. 2015 Mar; 147(3):618-625. Schmickl CN, Biehl M, Wilson GA, Gajic O. PMID: 25474475.

View in: PubMed Mentions: 9 Fields:
Pul Pulmonary Medicine
Translation:Humans
Male-predominant plasma transfusion strategy for preventing transfusion-related acute lung injury: a systematic review. Crit Care Med. 2015 Jan; 43(1):205-25. Schmickl CN, Mastrobuoni S, Filippidis FT, Shah S, Radic J, Murad MH, Toy P, Gajic O. PMID: 25514705.

View in: PubMed Mentions: 16 Fields:
Cri Critical Care
Translation:Humans
Decision support tool for differential diagnosis of Acute Respiratory Distress Syndrome (ARDS) vs Cardiogenic Pulmonary Edema (CPE): a prospective validation and meta-analysis. Crit Care. 2014 Nov 29; 18(6):659. Schmickl CN, Pannu S, Al-Qadi MO, Alsara A, Kashyap R, Dhokarh R, Herasevich V, Gajic O. PMID: 25432274; PMCID: PMC4277656.

View in: PubMed Mentions: 2 Fields:
Cri Critical Care
Translation:Humans
Customized reference ranges for laboratory values decrease false positive alerts in intensive care unit patients. PLoS One. 2014; 9(9):e107930. Kilickaya O, Schmickl C, Ahmed A, Pulido J, Onigkeit J, Kashani K, Gajic O, Herasevich V, Pickering B. PMID: 25233485; PMCID: PMC4169437.

View in: PubMed Mentions: 8 Fields:
Med Medicine (General)Sci Science
Translation:Humans
Drug-associated acute lung injury: a population-based cohort study. Chest. 2012 Oct; 142(4):845-850. Dhokarh R, Li G, Schmickl CN, Kashyap R, Assudani J, Limper AH, Gajic O. PMID: 22539646; PMCID: PMC3465105.

View in: PubMed Mentions: 13 Fields:
Pul Pulmonary Medicine
Translation:Humans PHPublic Health
Decision support tool for early differential diagnosis of acute lung injury and cardiogenic pulmonary edema in medical critically ill patients. Chest. 2012 Jan; 141(1):43-50. Schmickl CN, Shahjehan K, Li G, Dhokarh R, Kashyap R, Janish C, Alsara A, Jaffe AS, Hubmayr RD, Gajic O. PMID: 22030803; PMCID: PMC3416034.

View in: PubMed Mentions: 9 Fields:
Pul Pulmonary Medicine
Translation:Humans
The accuracy and efficiency of electronic screening for recruitment into a clinical trial on COPD. Respir Med. 2011 Oct; 105(10):1501-6. Schmickl CN, Li M, Li G, Wetzstein MM, Herasevich V, Gajic O, Benzo RP. PMID: 21576012; PMCID: PMC3156898.

View in: PubMed Mentions: 21 Fields:
Pul Pulmonary Medicine
Translation:Humans