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    Edmund Capparelli

    TitleSenate Emeritus
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0760
    CA La Jolla 92093
    Phone858-246-0009
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      Collapse Research 
      Collapse Research Activities and Funding
      Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
      NIH/NICHD U54HD090259Sep 20, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Developing Pediatric Clinical Pharmacologists for the Advancement of Therapeutics
      NIH/NICHD T32HD087978May 1, 2016 - Apr 30, 2021
      Role: Principal Investigator
      Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy
      NIH/NICHD U54HD071600Sep 26, 2011 - Jun 30, 2016
      Role: Principal Investigator
      Pediatric Pharmacology Research Unit Network
      NIH/NICHD U10HD031318Jan 1, 1994 - Dec 31, 2009
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Le J, Bradley JS, Hingtgen S, Skochko S, Black N, Jones RN, Lim M, Capparelli E. Pharmacokinetics of single-dose ceftaroline fosamil in children with cystic fibrosis. Pediatr Pulmonol. 2017 Sep 14. PMID: 28910514.
        View in: PubMed
      2. Hwang MF, Beechinor RJ, Wade KC, Benjamin DK, Smith PB, Hornik CP, Capparelli E, Duara S, Kennedy KA, Cohen-Wolkowiez M, Gonzalez D. External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models. Antimicrob Agents Chemother. 2017 Sep 11. PMID: 28893774.
        View in: PubMed
      3. Cressey TR, Punyawudho B, Le Coeur S, Jourdain G, Saenjum C, Capparelli E, Jittayanun K, Phanomcheong S, Luvira A, Borkird T, Puangsombat A, Aarons L, Sukrakanchana PO, Urien S, Lallemant M. Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates. J Acquir Immune Defic Syndr. 2017 Aug 15; 75(5):554-560. PMID: 28489732.
        View in: PubMed
      4. Gonzalez D, Chamberlain JM, Guptill JT, Cohen-Wolkowiez M, Harper B, Zhao J, Capparelli E. Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus. Clin Pharmacokinet. 2017 Aug; 56(8):941-951. PMID: 27943220.
        View in: PubMed
      5. Naviaux RK, Curtis B, Li K, Naviaux JC, Bright AT, Reiner GE, Westerfield M, Goh S, Alaynick WA, Wang L, Capparelli E, Adams C, Sun J, Jain S, He F, Arellano DA, Mash LE, Chukoskie L, Lincoln A, Townsend J. Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial. Ann Clin Transl Neurol. 2017 Jul; 4(7):491-505. PMID: 28695149.
        View in: PubMed
      6. Bolton Moore C, Capparelli E, Samson P, Bwakura-Dangarembizi M, Jean-Philippe P, Worrell C, Heckman B, Purdue L, Spector SA, Benns A, Borkowsky W, Loftis A, Hawkins E, Wallis C, Chadwick EG. CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection. AIDS. 2017 May 15; 31(8):1129-1136. PMID: 28323755.
        View in: PubMed
      7. Greenberg RG, Wu H, Laughon M, Capparelli E, Rowe S, Zimmerman KO, Smith PB, Cohen-Wolkowiez M. Population Pharmacokinetics of Dexmedetomidine in Infants. J Clin Pharmacol. 2017 Sep; 57(9):1174-1182. PMID: 28444697.
        View in: PubMed
      8. Huang Y, Zhang L, Ledgerwood J, Grunenberg N, Bailer R, Isaacs A, Seaton K, Mayer KH, Capparelli E, Corey L, Gilbert PB. Population pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults. MAbs. 2017 Jul; 9(5):792-800. PMID: 28368743.
        View in: PubMed
      9. Garimella PS, Li K, Naviaux JC, Shlipak MG, Abdelmalek JA, Castro E, Capparelli E, Naviaux RK, Ix JH. Utility of Spot Urine Specimens to Assess Tubular Secretion. Am J Kidney Dis. 2017 May; 69(5):709-711. PMID: 28284759.
        View in: PubMed
      10. Capparelli E, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 Jan; 61(1). PMID: 27821451.
        View in: PubMed
      11. Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli E, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. N Engl J Med. 2016 11 24; 375(21):2037-2050. PMID: 27959728.
        View in: PubMed
      12. Bouazza N, Cressey TR, Foissac F, Bienczak A, Denti P, McIlleron H, Burger D, Penazzato M, Lallemant M, Capparelli E, Treluyer JM, Urien S. Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients. J Antimicrob Chemother. 2017 Feb; 72(2):490-495. PMID: 27798221.
        View in: PubMed
      13. Momper JD, Capparelli E, Wade KC, Kantak A, Dhanireddy R, Cummings JJ, Nedrelow JH, Hudak ML, Mundakel GT, Natarajan G, Gao J, Laughon M, Smith PB, Benjamin DK. Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams. Antimicrob Agents Chemother. 2016 Sep; 60(9):5539-45. PMID: 27401564; PMCID: PMC4997840 [Available on 03/01/17].
      14. Hornik CP, Benjamin DK, Smith PB, Pencina MJ, Tremoulet AH, Capparelli E, Ericson JE, Clark RH, Cohen-Wolkowiez M. Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates. J Pediatr. 2016 Nov; 178:125-129.e1. PMID: 27522443.
        View in: PubMed
      15. Mulligan N, Schalkwijk S, Best BM, Colbers A, Wang J, Capparelli E, Moltó J, Stek AM, Taylor G, Smith E, Hidalgo Tenorio C, Chakhtoura N, van Kasteren M, Fletcher CV, Mirochnick M, Burger D. Etravirine Pharmacokinetics in HIV-Infected Pregnant Women. Front Pharmacol. 2016; 7:239. PMID: 27540363; PMCID: PMC4972814.
      16. Lam LH, Capparelli E, Kurzrock R. Association of concurrent acid-suppression therapy with survival outcomes and adverse event incidence in oncology patients receiving erlotinib. Cancer Chemother Pharmacol. 2016 Aug; 78(2):427-32. PMID: 27372908; PMCID: PMC4967016 [Available on 08/01/17].
      17. Tran AH, Best BM, Stek A, Wang J, Capparelli E, Burchett SK, Kreitchmann R, Rungruengthanakit K, George K, Cressey TR, Chakhtoura N, Smith E, Shapiro DE, Mirochnick M. Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women. J Acquir Immune Defic Syndr. 2016 Jul 01; 72(3):289-96. PMID: 26918544; PMCID: PMC4911231 [Available on 07/01/17].
      18. Atkinson JH, Slater MA, Capparelli E, Patel SM, Wolfson T, Gamst A, Abramson IS, Wallace MS, Funk SD, Rutledge TR, Wetherell JL, Matthews SC, Zisook S, Garfin SR. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016 07; 157(7):1499-507. PMID: 26963844; PMCID: PMC5001843 [Available on 07/01/17].
      19. Bradley JS, Flanagan SD, Arrieta AC, Jacobs R, Capparelli E, Prokocimer P. Pharmacokinetics, Safety and Tolerability of Single Oral or Intravenous Administration of 200 mg Tedizolid Phosphate in Adolescents. Pediatr Infect Dis J. 2016 06; 35(6):628-33. PMID: 26910588.
        View in: PubMed
      20. Shoji K, Bradley JS, Reed MD, van den Anker JN, Domonoske C, Capparelli E. Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms. Antimicrob Agents Chemother. 2016 Apr; 60(4):2150-6. PMID: 26810655; PMCID: PMC4808231 [Available on 10/01/16].
      21. Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P, Enama ME, Plummer S, Holman L, Hendel CS, Gordon I, Casazza J, Conan-Cibotti M, Migueles SA, Tressler R, Bailer RT, McDermott A, Narpala S, O'Dell S, Wolf G, Lifson JD, Freemire BA, Gorelick RJ, Pandey JP, Mohan S, Chomont N, Fromentin R, Chun TW, Fauci AS, Schwartz RM, Koup RA, Douek DC, Hu Z, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci Transl Med. 2015 Dec 23; 7(319):319ra206. PMID: 26702094.
        View in: PubMed
      22. Penazzato M, Lee J, Capparelli E, Essajee S, Ford N, Ojoo A, Pascual F, Sugandhi N, Lallemant M. Optimizing drugs to reach treatment targets for children and adolescents living with HIV. J Int AIDS Soc. 2015; 18(Suppl 6):20270. PMID: 26639117; PMCID: PMC4670841.
      23. Ledgerwood JE, Coates EE, Yamshchikov G, Saunders JG, Holman L, Enama ME, DeZure A, Lynch RM, Gordon I, Plummer S, Hendel CS, Pegu A, Conan-Cibotti M, Sitar S, Bailer RT, Narpala S, McDermott A, Louder M, O'Dell S, Mohan S, Pandey JP, Schwartz RM, Hu Z, Koup RA, Capparelli E, Mascola JR, Graham BS. Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults. Clin Exp Immunol. 2015 Dec; 182(3):289-301. PMID: 26332605; PMCID: PMC4636891 [Available on 12/01/16].
      24. Stek A, Best BM, Wang J, Capparelli E, Burchett SK, Kreitchmann R, Rungruengthanakit K, Cressey TR, Mofenson LM, Smith E, Shapiro D, Mirochnick M. Pharmacokinetics of Once Versus Twice Daily Darunavir in Pregnant HIV-Infected Women. J Acquir Immune Defic Syndr. 2015 Sep 01; 70(1):33-41. PMID: 25950206; PMCID: PMC4579345.
      25. Uprety P, Chadwick EG, Rainwater-Lovett K, Ziemniak C, Luzuriaga K, Capparelli E, Yenokyan G, Persaud D. Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants. Clin Infect Dis. 2015 Dec 15; 61(12):1862-70. PMID: 26270687; PMCID: PMC4657533 [Available on 12/15/16].
      26. Colbers A, Best B, Schalkwijk S, Wang J, Stek A, Hidalgo Tenorio C, Hawkins D, Taylor G, Kreitchmann R, Burchett S, Haberl A, Kabeya K, van Kasteren M, Smith E, Capparelli E, Burger D, Mirochnick M. Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women. Clin Infect Dis. 2015 Nov 15; 61(10):1582-9. PMID: 26202768; PMCID: PMC4614410 [Available on 11/15/16].
      27. Le J, Capparelli E, Wahid U, Wu YS, Romanowski GL, Tran TM, Nguyen A, Bradley JS. Bayesian Estimation of Vancomycin Pharmacokinetics in Obese Children: Matched Case-Control Study. Clin Ther. 2015 Jun 01; 37(6):1340-51. PMID: 26031618; PMCID: PMC4475435.
      28. Best BM, Burchett S, Li H, Stek A, Hu C, Wang J, Hawkins E, Byroads M, Watts DH, Smith E, Fletcher CV, Capparelli E, Mirochnick M. Pharmacokinetics of tenofovir during pregnancy and postpartum. HIV Med. 2015 Sep; 16(8):502-11. PMID: 25959631; PMCID: PMC4862736.
      29. Watt KM, Gonzalez D, Benjamin DK, Brouwer KL, Wade KC, Capparelli E, Barrett J, Cohen-Wolkowiez M. Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation. Antimicrob Agents Chemother. 2015 Jul; 59(7):3935-43. PMID: 25896706; PMCID: PMC4468733.
      30. Bartelink IH, Savic RM, Dorsey G, Ruel T, Gingrich D, Scherpbier HJ, Capparelli E, Jullien V, Young SL, Achan J, Plenty A, Charlebois E, Kamya M, Havlir D, Aweeka F. The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda. Pediatr Infect Dis J. 2015 Mar; 34(3):e63-70. PMID: 25742090; PMCID: PMC4351793.
      31. Nikanjam M, Stewart CF, Takimoto CH, Synold TW, Beaty O, Fouladi M, Capparelli E. Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing. Cancer Chemother Pharmacol. 2015 Mar; 75(3):495-503. PMID: 25557868; PMCID: PMC4344382.
      32. Watts DH, Stek A, Best BM, Wang J, Capparelli E, Cressey TR, Aweeka F, Lizak P, Kreitchmann R, Burchett SK, Shapiro DE, Hawkins E, Smith E, Mirochnick M. Raltegravir pharmacokinetics during pregnancy. J Acquir Immune Defic Syndr. 2014 Dec 01; 67(4):375-81. PMID: 25162818; PMCID: PMC4213295.
      33. Aweeka FT, Hu C, Huang L, Best BM, Stek A, Lizak P, Burchett SK, Read JS, Watts H, Mirochnick M, Capparelli E. Alteration in cytochrome P450 3A4 activity as measured by a urine cortisol assay in HIV-1-infected pregnant women and relationship to antiretroviral pharmacokinetics. HIV Med. 2015 Mar; 16(3):176-83. PMID: 25407158; PMCID: PMC4320673.
      34. Le J, Ny P, Capparelli E, Lane J, Ngu B, Muus R, Romanowski G, Vo T, Bradley J. Pharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children. J Pediatric Infect Dis Soc. 2015 Dec; 4(4):e109-16. PMID: 26582878.
        View in: PubMed
      35. Dross SE, Rossi SS, Beck IA, Micek MA, Blanco AJ, Seidel KD, Montoya P, Capparelli E, Frenkel LM. Variable and suboptimal nevirapine levels in infants given single-dose nevirapine at birth without maternal prophylaxis. AIDS. 2014 Oct 23; 28(16):2491-3. PMID: 25265235; PMCID: PMC4332529.
      36. Bouazza N, Foissac F, Fauchet F, Burger D, Kiechel JR, Treluyer JM, Capparelli E, Lallemant M, Urien S. Lopinavir/ritonavir plus lamivudine and abacavir or zidovudine dose ratios for paediatric fixed-dose combinations. Antivir Ther. 2015; 20(2):225-33. PMID: 25279808.
        View in: PubMed
      37. Chao T, Perry JC, Romanowski GL, Tremoulet AH, Capparelli E. Optimizing pediatric esmolol dosing using computerized practitioner order entry. J Pediatr Pharmacol Ther. 2014 Oct-Dec; 19(4):302-9. PMID: 25762876; PMCID: PMC4341416.
      38. Autmizguine J, Moran C, Gonzalez D, Capparelli E, Smith PB, Grant GA, Benjamin DK, Cohen-Wolkowiez M, Watt KM. Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections. Pediatr Infect Dis J. 2014 Oct; 33(10):e270-2. PMID: 24776517; PMCID: PMC4209191.
      39. Sampson MR, Frymoyer A, Rattray B, Cotten CM, Smith PB, Capparelli E, Bonifacio SL, Cohen-Wolkowiez M. Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia. Ther Drug Monit. 2014 Oct; 36(5):584-9. PMID: 25225917; PMCID: PMC4166612.
      40. Cressey TR, Urien S, Capparelli E, Best BM, Buranabanjasatean S, Limtrakul A, Rawangban B, Sabsanong P, Treluyer JM, Jourdain G, Stek A, Lallemant M, Mirochnick M. Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy. J Antimicrob Chemother. 2015 Jan; 70(1):217-24. PMID: 25261418; PMCID: PMC4267507.
      41. Le J, Ngu B, Bradley JS, Murray W, Nguyen A, Nguyen L, Romanowski GL, Vo T, Capparelli E. Vancomycin monitoring in children using bayesian estimation. Ther Drug Monit. 2014 Aug; 36(4):510-8. PMID: 24452067; PMCID: PMC4101060.
      42. Andrade RM, Chaparro JD, Capparelli E, Reed SL. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. PLoS Negl Trop Dis. 2014; 8(7):e2973. PMID: 25079790; PMCID: PMC4117455.
      43. Gonzalez D, Melloni C, Yogev R, Poindexter BB, Mendley SR, Delmore P, Sullivan JE, Autmizguine J, Lewandowski A, Harper B, Watt KM, Lewis KC, Capparelli E, Benjamin DK, Cohen-Wolkowiez M. Use of opportunistic clinical data and a population pharmacokinetic model to support dosing of clindamycin for premature infants to adolescents. Clin Pharmacol Ther. 2014 Oct; 96(4):429-37. PMID: 24949994; PMCID: PMC4169790.
      44. Autmizguine J, Guptill JT, Cohen-Wolkowiez M, Benjamin DK, Capparelli E. Pharmacokinetics and pharmacodynamics of antifungals in children: clinical implications. Drugs. 2014 Jun; 74(8):891-909. PMID: 24872147; PMCID: PMC4073603.
      45. Cohen-Wolkowiez M, Watt KM, Zhou C, Bloom BT, Poindexter B, Castro L, Gao J, Capparelli E, Benjamin DK, Smith PB. Developmental pharmacokinetics of piperacillin and tazobactam using plasma and dried blood spots from infants. Antimicrob Agents Chemother. 2014 May; 58(5):2856-65. PMID: 24614369; PMCID: PMC3993246.
      46. Tremoulet A, Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Salgado A, Ian-U Chong S, Melloni C, Gao J, Benjamin DK, Capparelli E, Cohen-Wolkowiez M. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014 Jun; 58(6):3013-20. PMID: 24614374; PMCID: PMC4068432.
      47. Sampson MR, Bloom BT, Arrieta A, Capparelli E, Benjamin DK, Smith PB, Kearns GL, van den Anker J, Cohen-Wolkowiez M. Intestinal fatty-acid binding protein and metronidazole response in premature infants. J Neonatal Perinatal Med. 2014 Jan 01; 7(3):223-8. PMID: 25318626; PMCID: PMC4225165.
      48. Le J, Vaida F, Nguyen E, Adler-Shohet FC, Romanowski G, Kim J, Vo T, Capparelli E. Population-Based Pharmacokinetic Modeling of Vancomycin in Children with Renal Insufficiency. J Pharmacol Clin Toxicol. 2014; 2(1):1017-1026. PMID: 25309945.
        View in: PubMed
      49. Sampson MR, Bloom BT, Lenfestey RW, Harper B, Kashuba AD, Anand R, Benjamin DK, Capparelli E, Cohen-Wolkowiez M, Smith PB. Population pharmacokinetics of intravenous acyclovir in preterm and term infants. Pediatr Infect Dis J. 2014 Jan; 33(1):42-9. PMID: 24346595; PMCID: PMC3904301.
      50. Cohen-Wolkowiez M, Sampson M, Bloom BT, Arrieta A, Wynn JL, Martz K, Harper B, Kearns GL, Capparelli E, Siegel D, Benjamin DK, Smith PB. Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants. Pediatr Infect Dis J. 2013 Sep; 32(9):956-61. PMID: 23587979; PMCID: PMC3769518.
      51. Cressey TR, Best BM, Achalapong J, Stek A, Wang J, Chotivanich N, Yuthavisuthi P, Suriyachai P, Prommas S, Shapiro DE, Watts DH, Smith E, Capparelli E, Kreitchmann R, Mirochnick M. Reduced indinavir exposure during pregnancy. Br J Clin Pharmacol. 2013 Sep; 76(3):475-83. PMID: 23305215; PMCID: PMC3769674.
      52. Hornik CP, Herring AH, Benjamin DK, Capparelli E, Kearns GL, van den Anker J, Cohen-Wolkowiez M, Clark RH, Smith PB. Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants. Pediatr Infect Dis J. 2013 Jul; 32(7):748-53. PMID: 23838776; PMCID: PMC3708263.
      53. Le J, Bradley JS, Murray W, Romanowski GL, Tran TT, Nguyen N, Cho S, Natale S, Bui I, Tran TM, Capparelli E. Improved vancomycin dosing in children using area under the curve exposure. Pediatr Infect Dis J. 2013 Apr; 32(4):e155-63. PMID: 23340565; PMCID: PMC3632448.
      54. Hoffman JT, Rossi SS, Espina-Quinto R, Letendre S, Capparelli E. Determination of efavirenz in human dried blood spots by reversed-phase high-performance liquid chromatography with UV detection. Ther Drug Monit. 2013 Apr; 35(2):203-8. PMID: 23503446; PMCID: PMC3848783.
      55. Zhao W, Kaguelidou F, Biran V, Zhang D, Allegaert K, Capparelli E, Holford N, Kimura T, Lo YL, Peris JE, Thomson A, van den Anker JN, Fakhoury M, Jacqz-Aigrain E. External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings. Br J Clin Pharmacol. 2013 Apr; 75(4):1068-80. PMID: 23148919; PMCID: PMC3612725.
      56. Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S. Etravirine in CSF is highly protein bound. J Antimicrob Chemother. 2013 May; 68(5):1161-8. PMID: 23335197; PMCID: PMC3625433.
      57. Shapiro RL, Rossi S, Ogwu A, Moss M, Leidner J, Moffat C, Lockman S, Moyo S, Makhema J, Essex M, Capparelli E. Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana. Antivir Ther. 2013; 18(4):585-90. PMID: 23183881.
        View in: PubMed
      58. Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S. Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration. J Antimicrob Chemother. 2013 Mar; 68(3):684-9. PMID: 23143899; PMCID: PMC3566670.
      59. Krekels EH, Neely M, Panoilia E, Tibboel D, Capparelli E, Danhof M, Mirochnick M, Knibbe CA. From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine. CPT Pharmacometrics Syst Pharmacol. 2012 Oct 03; 1:e9. PMID: 23887364; PMCID: PMC3603431.
      60. Watt KM, Benjamin DK, Cheifetz IM, Moorthy G, Wade KC, Smith PB, Brouwer KL, Capparelli E, Cohen-Wolkowiez M. Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. Pediatr Infect Dis J. 2012 Oct; 31(10):1042-7. PMID: 22627870; PMCID: PMC3444624.
      61. Cohen-Wolkowiez M, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Randolph DA, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Rich W, Brozanski BS, van den Anker J, Blumer J, Laughon M, Watt KM, Kearns GL, Capparelli E, Martz K, Berezny K, Benjamin DK, Smith PB. Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections. Clin Infect Dis. 2012 Dec; 55(11):1495-502. PMID: 22955430; PMCID: PMC3491861.
      62. Nikanjam M, Kabamba D, Cressey TR, Burger D, Aweeka FT, Acosta EP, Spector SA, Capparelli E. Nevirapine exposure with WHO pediatric weight band dosing: enhanced therapeutic concentrations predicted based on extensive international pharmacokinetic experience. Antimicrob Agents Chemother. 2012 Oct; 56(10):5374-80. PMID: 22869579; PMCID: PMC3457371.
      63. Persaud D, Palumbo PE, Ziemniak C, Hughes MD, Alvero CG, Luzuriaga K, Yogev R, Capparelli E, Chadwick EG. Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age. AIDS. 2012 Jul 31; 26(12):1483-90. PMID: 22555165; PMCID: PMC3495308.
      64. Rakhmanina NY, Dirajlal-Fargo S, Capparelli E, Mirochnik M. Pharmacokinetic considerations of perinatal antiretroviral therapy. Curr Drug Metab. 2012 Jul; 13(6):744-59. PMID: 22452457.
        View in: PubMed
      65. Rakhmanina NY, Neely MN, Capparelli E. High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count. Ther Drug Monit. 2012 Jun; 34(3):237-41. PMID: 22549499; PMCID: PMC3354040.
      66. Sharpe CM, Capparelli E, Mower A, Farrell MJ, Soldin SJ, Haas RH. A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur during the first week of life. Pediatr Res. 2012 Jul; 72(1):43-9. PMID: 22495532.
        View in: PubMed
      67. Prasitsuebsai W, Cressey TR, Capparelli E, Vanprapar N, Lapphra K, Chokephaibulkit K. Pharmacokinetics of nevirapine in HIV and tuberculosis-coinfected children receiving antiretroviral fixed-dose combination tablets while receiving rifampicin-containing tuberculosis treatment and after rifampicin discontinuation. Pediatr Infect Dis J. 2012 Apr; 31(4):389-91. PMID: 22146740.
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      68. Best BM, Letendre SL, Koopmans P, Rossi SS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Capparelli E, Ellis RJ, Grant I. Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir. J Acquir Immune Defic Syndr. 2012 Apr 01; 59(4):376-81. PMID: 22217676; PMCID: PMC3299895.
      69. Cressey TR, Stek A, Capparelli E, Bowonwatanuwong C, Prommas S, Sirivatanapa P, Yuthavisuthi P, Neungton C, Huo Y, Smith E, Best BM, Mirochnick M. Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum. J Acquir Immune Defic Syndr. 2012 Mar 01; 59(3):245-52. PMID: 22083071; PMCID: PMC3288559.
      70. Croteau D, Letendre S, Best BM, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Way L, Capparelli E, Grant I. Therapeutic amprenavir concentrations in cerebrospinal fluid. Antimicrob Agents Chemother. 2012 Apr; 56(4):1985-9. PMID: 22290964; PMCID: PMC3318381.
      71. Nikanjam M, Chadwick EG, Robbins B, Alvero C, Palumbo P, Yogev R, Pinto J, Hazra R, Hughes ML, Heckman BE, Capparelli E. Assessment of lopinavir pharmacokinetics with respect to developmental changes in infants and the impact on weight band-based dosing. Clin Pharmacol Ther. 2012 Feb; 91(2):243-9. PMID: 22190064; PMCID: PMC3356582.
      72. Tremoulet AH, Nikanjam M, Cressey TR, Chokephaibulkit K, McKinney R, Mirochnick M, Capparelli E. Developmental pharmacokinetic changes of Lamivudine in infants and children. J Clin Pharmacol. 2012 Dec; 52(12):1824-32. PMID: 22180560; PMCID: PMC3369109.
      73. Best BM, Capparelli E, Diep H, Rossi SS, Farrell MJ, Williams E, Lee G, van den Anker JN, Rakhmanina N. Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children. J Acquir Immune Defic Syndr. 2011 Dec 01; 58(4):385-91. PMID: 21876444; PMCID: PMC3205189.
      74. Stek AM, Best BM, Luo W, Capparelli E, Burchett S, Hu C, Li H, Read JS, Jennings A, Barr E, Smith E, Rossi SS, Mirochnick M. Effect of pregnancy on emtricitabine pharmacokinetics. HIV Med. 2012 Apr; 13(4):226-35. PMID: 22129166; PMCID: PMC3342997.
      75. Chamberlain JM, Capparelli E, Brown KM, Vance CW, Lillis K, Mahajan P, Lichenstein R, Stanley RM, Davis CO, Gordon S, Baren JM, van den Anker JN. Pharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus. J Pediatr. 2012 Apr; 160(4):667-672.e2. PMID: 22050870; PMCID: PMC3274567.
      76. Lawson EB, Wu JC, Baldwin RM, Ingelman-Sundberg M, Rosenborg S, Yim DS, Yin OQ, Capparelli E, Ma JD. Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping. Eur J Clin Pharmacol. 2012 Apr; 68(4):407-13. PMID: 22009190.
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      77. Smith PB, Cohen-Wolkowiez M, Castro LM, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Bhatt-Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Brozanski BS, Sanchez P, van den Anker J, Blumer J, Kearns GL, Capparelli E, Anand R, Benjamin DK. Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. Pediatr Infect Dis J. 2011 Oct; 30(10):844-9. PMID: 21829139; PMCID: PMC3173561.
      78. Laughon MM, Benjamin DK, Capparelli E, Kearns GL, Berezny K, Paul IM, Wade K, Barrett J, Smith PB, Cohen-Wolkowiez M. Innovative clinical trial design for pediatric therapeutics. Expert Rev Clin Pharmacol. 2011 Sep; 4(5):643-52. PMID: 21980319; PMCID: PMC3184526.
      79. Morris CA, Onyamboko MA, Capparelli E, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright L, Tshefu AK, Meshnick S, Fleckenstein L. Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria. Malar J. 2011 May 08; 10:114. PMID: 21548983; PMCID: PMC3098207.
      80. Mirochnick M, Best BM, Stek AM, Capparelli E, Hu C, Burchett SK, Rossi SS, Hawkins E, Basar M, Smith E, Read JS. Atazanavir pharmacokinetics with and without tenofovir during pregnancy. J Acquir Immune Defic Syndr. 2011 Apr 15; 56(5):412-9. PMID: 21283017; PMCID: PMC3125419.
      81. Cohen-Wolkowiez M, Benjamin DK, Piper L, Cheifetz IM, Moran C, Liu P, Aram J, Kashuba AD, Capparelli E, Walsh TJ, Hope WW, Smith PB. Safety and pharmacokinetics of multiple-dose anidulafungin in infants and neonates. Clin Pharmacol Ther. 2011 May; 89(5):702-7. PMID: 21412233; PMCID: PMC3124385.
      82. Chadwick EG, Yogev R, Alvero CG, Hughes MD, Hazra R, Pinto JA, Robbins BL, Heckman BE, Palumbo PE, Capparelli E. Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy. AIDS. 2011 Mar 13; 25(5):643-9. PMID: 21297419; PMCID: PMC3068474.
      83. Onyamboko MA, Meshnick SR, Fleckenstein L, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright LL, Tshefu AK, Capparelli E. Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC. Malar J. 2011 Feb 28; 10:49. PMID: 21352601; PMCID: PMC3056842.
      84. Barshop NJ, Capparelli E, Sirlin CB, Schwimmer JB, Lavine JE. Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):198-202. PMID: 21240014; PMCID: PMC3059772.
      85. Innes S, Norman J, Smith P, Smuts M, Capparelli E, Rosenkranz B, Cotton M. Bioequivalence of dispersed stavudine: opened versus closed capsule dosing. Antivir Ther. 2011; 16(7):1131-4. PMID: 22024529.
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      86. Chokephaibulkit K, Cressey TR, Capparelli E, Sirisanthana V, Muresan P, Hongsiriwon S, Ngampiyaskul C, Limwongse C, Wittawatmongkol O, Aurpibul L, Kabat B, Toye M, Smith ME, Eksaengsri A, McIntosh K, Yogev R. Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine in HIV-infected children. Antivir Ther. 2011; 16(8):1287-95. PMID: 22155910; PMCID: PMC3348490.
      87. Best BM, Koopmans PP, Letendre SL, Capparelli E, Rossi SS, Clifford DB, Collier AC, Gelman BB, Mbeo G, McCutchan JA, Simpson DM, Haubrich R, Ellis R, Grant I. Efavirenz concentrations in CSF exceed IC50 for wild-type HIV. J Antimicrob Chemother. 2011 Feb; 66(2):354-7. PMID: 21098541; PMCID: PMC3019085.
      88. Vanprapar N, Cressey TR, Chokephaibulkit K, Muresan P, Plipat N, Sirisanthana V, Prasitsuebsai W, Hongsiriwan S, Chotpitayasunondh T, Eksaengsri A, Toye M, Smith ME, McIntosh K, Capparelli E, Yogev R. A chewable pediatric fixed-dose combination tablet of stavudine, lamivudine, and nevirapine: pharmacokinetics and safety compared with the individual liquid formulations in human immunodeficiency virus-infected children in Thailand. Pediatr Infect Dis J. 2010 Oct; 29(10):940-4. PMID: 20453709; PMCID: PMC2981099.
      89. Croteau D, Letendre S, Best BM, Ellis RJ, Breidinger S, Clifford D, Collier A, Gelman B, Marra C, Mbeo G, McCutchan A, Morgello S, Simpson D, Way L, Vaida F, Ueland S, Capparelli E, Grant I. Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1. Antimicrob Agents Chemother. 2010 Dec; 54(12):5156-60. PMID: 20876368; PMCID: PMC2981289.
      90. Best BM, Stek AM, Mirochnick M, Hu C, Li H, Burchett SK, Rossi SS, Smith E, Read JS, Capparelli E. Lopinavir tablet pharmacokinetics with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2010 Aug; 54(4):381-8. PMID: 20632458; PMCID: PMC3265163.
      91. Sánchez JL, Dominguez AR, Lane JR, Anderson PO, Capparelli E, Cornejo-Bravo JM. Population pharmacokinetics of vancomycin in adult and geriatric patients: comparison of eleven approaches. Int J Clin Pharmacol Ther. 2010 Aug; 48(8):525-33. PMID: 20650044.
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      92. Saitoh A, Capparelli E, Aweeka F, Sarles E, Singh KK, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton T, Spector SA. CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2010 Jul; 54(3):285-9. PMID: 19890215; PMCID: PMC3119357.
      93. Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli E, Adamson PC. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 04; 362(9):790-9. PMID: 20200383; PMCID: PMC2924476.
      94. Aweeka FT, Stek A, Best BM, Hu C, Holland D, Hermes A, Burchett SK, Read J, Mirochnick M, Capparelli E. Lopinavir protein binding in HIV-1-infected pregnant women. HIV Med. 2010 Apr; 11(4):232-8. PMID: 20002783; PMCID: PMC2874627.
      95. Chantarangsu S, Cressey TR, Mahasirimongkol S, Capparelli E, Tawon Y, Ngo-Giang-Huong N, Jourdain G, Lallemant M, Chantratita W. Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women. J Antimicrob Chemother. 2009 Dec; 64(6):1265-73. PMID: 19812066; PMCID: PMC2775665.
      96. James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM. Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos. 2009 Aug; 37(8):1779-84. PMID: 19439490; PMCID: PMC2712440.
      97. Malloy J, Capparelli E, Gottschalk M, Guan X, Kothare P, Fineman M. Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: a randomized, placebo-controlled, single-blind, dose-escalation, crossover study. Clin Ther. 2009 Apr; 31(4):806-15. PMID: 19446153.
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      98. Cohen-Wolkowiez M, Benjamin DK, Capparelli E. Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr. 2009 Apr; 21(2):177-81. PMID: 19276977; PMCID: PMC3319032.
      99. Atkinson JH, Patel SM, Meyer JM, Slater MA, Zisook S, Capparelli E. Is there a therapeutic window with some antidepressants for analgesic response? Curr Pain Headache Rep. 2009 Apr; 13(2):93-9. PMID: 19272274.
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      100. Chadwick EG, Pinto J, Yogev R, Alvero CG, Hughes MD, Palumbo P, Robbins B, Hazra R, Serchuck L, Heckman BE, Purdue L, Browning R, Luzuriaga K, Rodman J, Capparelli E. Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacy. Pediatr Infect Dis J. 2009 Mar; 28(3):215-9. PMID: 19209098; PMCID: PMC3176632.
      101. Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli E, Grant I. Low atazanavir concentrations in cerebrospinal fluid. AIDS. 2009 Jan 02; 23(1):83-7. PMID: 19050389; PMCID: PMC2642983.
      102. Sleasman JW, Robbins BL, Cross SJ, Lindsey JC, Kraimer JM, Heckman BE, Sprenger HL, Tustin NB, Rose CH, Poston PA, Neal EF, Pakes GE, Nikanjam M, Capparelli E. Abacavir pharmacokinetics during chronic therapy in HIV-1-infected adolescents and young adults. Clin Pharmacol Ther. 2009 Apr; 85(4):394-401. PMID: 19118380; PMCID: PMC2767189.
      103. Mirochnick M, Thomas T, Capparelli E, Zeh C, Holland D, Masaba R, Odhiambo P, Fowler MG, Weidle PJ, Thigpen MC. Antiretroviral concentrations in breast-feeding infants of mothers receiving highly active antiretroviral therapy. Antimicrob Agents Chemother. 2009 Mar; 53(3):1170-6. PMID: 19114673; PMCID: PMC2650559.
      104. Mirochnick M, Best BM, Stek AM, Capparelli E, Hu C, Burchett SK, Holland DT, Smith E, Gaddipati S, Read JS. Lopinavir exposure with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2008 Dec 15; 49(5):485-91. PMID: 18989231; PMCID: PMC3912695.
      105. Newfield RS, Cohen D, Capparelli E, Shragg P. Rapid weight gain in children soon after diagnosis of type 1 diabetes: is there room for concern? Pediatr Diabetes. 2009 Aug; 10(5):310-5. PMID: 19067888.
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      106. Capparelli E, Syed SS. Nitazoxanide treatment of Cryptosporidium parvum in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 2008 Nov; 27(11):1041. PMID: 18818555; PMCID: PMC3974820.
      107. James LP, Capparelli E, Simpson PM, Letzig L, Roberts D, Hinson JA, Kearns GL, Blumer JL, Sullivan JE. Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose. Clin Pharmacol Ther. 2008 Dec; 84(6):684-90. PMID: 18923390; PMCID: PMC2929246.
      108. Rakhmanina NY, Capparelli E, van den Anker JN. Personalized therapeutics: HIV treatment in adolescents. Clin Pharmacol Ther. 2008 Dec; 84(6):734-40. PMID: 18830226; PMCID: PMC2803031.
      109. Read JS, Best BM, Stek AM, Hu C, Capparelli E, Holland DT, Burchett SK, Smith ME, Sheeran EC, Shearer WT, Febo I, Mirochnick M. Pharmacokinetics of new 625 mg nelfinavir formulation during pregnancy and postpartum. HIV Med. 2008 Nov; 9(10):875-82. PMID: 18795962; PMCID: PMC2732353.
      110. Bradley JS, Sauberan JB, Ambrose PG, Bhavnani SM, Rasmussen MR, Capparelli E. Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate. Pediatr Infect Dis J. 2008 Sep; 27(9):794-9. PMID: 18645546.
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      111. Burns JC, Best BM, Mejias A, Mahony L, Fixler DE, Jafri HS, Melish ME, Jackson MA, Asmar BI, Lang DJ, Connor JD, Capparelli E, Keen ML, Mamun K, Keenan GF, Ramilo O. Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2008 Dec; 153(6):833-8. PMID: 18672254; PMCID: PMC2856847.
      112. Robbins BL, Capparelli E, Chadwick EG, Yogev R, Serchuck L, Worrell C, Smith ME, Alvero C, Fenton T, Heckman B, Pelton SI, Aldrovandi G, Borkowsky W, Rodman J, Havens PL. Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors. Antimicrob Agents Chemother. 2008 Sep; 52(9):3276-83. PMID: 18625762; PMCID: PMC2533475.
      113. Best BM, Capparelli E. Implications of gender and pregnancy for antiretroviral drug dosing. Curr Opin HIV AIDS. 2008 May; 3(3):277-82. PMID: 19372979; PMCID: PMC2804899.
      114. Capparelli E, Aweeka F, Hitti J, Stek A, Hu C, Burchett SK, Best B, Smith E, Read JS, Watts H, Nachman S, Thorpe EM, Spector SA, Jimenez E, Shearer WT, Foca M, Mirochnick M. Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics. HIV Med. 2008 Apr; 9(4):214-20. PMID: 18366444; PMCID: PMC2755564.
      115. Bryson YJ, Mirochnick M, Stek A, Mofenson LM, Connor J, Capparelli E, Watts DH, Huang S, Hughes MD, Kaiser K, Purdue L, Asfaw Y, Keller M, Smith E. Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353. HIV Clin Trials. 2008 Mar-Apr; 9(2):115-25. PMID: 18474496; PMCID: PMC4043374.
      116. Borkowsky W, Yogev R, Muresan P, McFarland E, Frenkel L, Fenton T, Capparelli E, Moye J, Harding P, Ellis N, Heckman B, Kraimer J. Planned multiple exposures to autologous virus in HIV type 1-infected pediatric populations increases HIV-specific immunity and reduces HIV viremia. AIDS Res Hum Retroviruses. 2008 Mar; 24(3):401-11. PMID: 18327977.
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      117. Darbari DS, van Schaik RH, Capparelli E, Rana S, McCarter R, van den Anker J. UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Am J Hematol. 2008 Mar; 83(3):200-2. PMID: 17724700.
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      118. Chadwick EG, Capparelli E, Yogev R, Pinto JA, Robbins B, Rodman JH, Chen J, Palumbo P, Serchuck L, Smith E, Hughes M. Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results. AIDS. 2008 Jan 11; 22(2):249-55. PMID: 18097227.
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      119. Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ. Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol. 2008 Jan; 65(1):65-70. PMID: 18195140; PMCID: PMC2763187.
      120. Best BM, Goicoechea M, Witt MD, Miller L, Daar ES, Diamond C, Tilles JG, Kemper CA, Larsen R, Holland DT, Sun S, Jain S, Wagner G, Capparelli E, McCutchan JA, Haubrich RH. A randomized controlled trial of therapeutic drug monitoring in treatment-naive and -experienced HIV-1-infected patients. J Acquir Immune Defic Syndr. 2007 Dec 01; 46(4):433-42. PMID: 17786128.
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      121. Saitoh A, Sarles E, Capparelli E, Aweeka F, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton T, Spector SA. CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS. 2007 Oct 18; 21(16):2191-9. PMID: 18090046.
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      122. Tremoulet AH, Capparelli E, Patel P, Acosta EP, Luzuriaga K, Bryson Y, Wara D, Zorrilla C, Holland D, Mirochnick M. Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants. Antimicrob Agents Chemother. 2007 Dec; 51(12):4297-302. PMID: 17893155; PMCID: PMC2168008.
      123. Díaz SM, Rodarte A, Foley J, Capparelli E. Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study. Pediatr Crit Care Med. 2007 Sep; 8(5):419-24. PMID: 17693909.
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      124. Flynn PM, Rodman J, Lindsey JC, Robbins B, Capparelli E, Knapp KM, Rodriguez JF, McNamara J, Serchuck L, Heckman B, Martinez J. Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents. Antimicrob Agents Chemother. 2007 Oct; 51(10):3516-22. PMID: 17664328; PMCID: PMC2043291.
      125. Capparelli E. Pharmacologic, pharmacodynamic, and pharmacokinetic considerations with intravenous Ibuprofen lysine. J Pediatr Pharmacol Ther. 2007 Jul; 12(3):158-70. PMID: 23055851; PMCID: PMC3462098.
      126. Atkinson JH, Slater MA, Capparelli E, Wallace MS, Zisook S, Abramson I, Matthews SC, Garfin SR. Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. J Clin Psychopharmacol. 2007 Apr; 27(2):135-42. PMID: 17414235.
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      127. Rakhmanina NY, Capparelli E, van den Anker JN, Williams K, Sever JL, Spiegel HM, Soldin SJ. Nevirapine concentration in nonstimulated saliva: an alternative to plasma sampling in children with human immunodeficiency virus infection. Ther Drug Monit. 2007 Feb; 29(1):110-7. PMID: 17304158.
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      128. Rubino CM, Capparelli E, Bradley JS, Blumer JL, Kearns GL, Reed M, Jacobs RF, Cirincione B, Grasela DM. Population pharmacokinetic model for gatifloxacin in pediatric patients. Antimicrob Agents Chemother. 2007 Apr; 51(4):1246-52. PMID: 17220409; PMCID: PMC1855513.
      129. May S, Letendre S, Haubrich R, McCutchan JA, Heaton R, Capparelli E, Ellis R. Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS. J Neuroimmune Pharmacol. 2007 Mar; 2(1):97-104. PMID: 18040832.
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      130. Goicoechea M, Vidal A, Capparelli E, Rigby A, Kemper C, Diamond C, Witt MD, Haubrich R. A computer-based system to aid in the interpretation of plasma concentrations of antiretrovirals for therapeutic drug monitoring. Antivir Ther. 2007; 12(1):55-62. PMID: 17503748.
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      131. Goicoechea M, Best B, Capparelli E, Caperna J, Ballard C, Haubrich R. Therapeutic ritonavir-boosted atazanavir plasma concentration and concurrent omeprazole use. AIDS. 2006 Oct 24; 20(16):2127-8. PMID: 17053363.
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      132. Stek AM, Mirochnick M, Capparelli E, Best BM, Hu C, Burchett SK, Elgie C, Holland DT, Smith E, Tuomala R, Cotter A, Read JS. Reduced lopinavir exposure during pregnancy. AIDS. 2006 Oct 03; 20(15):1931-9. PMID: 16988514.
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      133. Goicoechea M, Best B, Capparelli E, Haubrich R. Concurrent use of efavirenz and oxcarbazepine may not affect efavirenz plasma concentrations. Clin Infect Dis. 2006 Jul 01; 43(1):116-7. PMID: 16758435.
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      134. Goicoechea M, Best B, Seefried E, Wagner G, Capparelli E, Haubrich R. Failure of modified directly observed therapy combined with therapeutic drug monitoring to enhance antiretroviral adherence in a patient with major depression. AIDS Patient Care STDS. 2006 Apr; 20(4):233-7. PMID: 16623621.
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      135. Lee CK, Rowinsky EK, Li J, Giles F, Moore MJ, Hidalgo M, Capparelli E, Jolivet J, Baker SD. Population pharmacokinetics of troxacitabine, a novel dioxolane nucleoside analogue. Clin Cancer Res. 2006 Apr 01; 12(7 Pt 1):2158-65. PMID: 16609029.
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      136. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli E, Carlo W, Hummel P, Johnston CC, Lantos J, Tutag-Lehr V, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22. PMID: 16777824.
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      137. Best BM, Mirochnick M, Capparelli E, Stek A, Burchett SK, Holland DT, Read JS, Smith E, Hu C, Spector SA, Connor JD. Impact of pregnancy on abacavir pharmacokinetics. AIDS. 2006 Feb 28; 20(4):553-60. PMID: 16470119.
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      138. Christensen ML, Meibohm B, Capparelli E, Velasquez-Mieyer P, Burghen GA, Tamborlane WV. Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes. J Clin Pharmacol. 2005 Oct; 45(10):1137-44. PMID: 16172178.
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      139. Capparelli E, Bloom BT, Kueser TJ, Oelberg DG, Bifano EM, White RD, Schelonka RL, Pearlman SA, Patti J, Hetherington SV. Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants. Antimicrob Agents Chemother. 2005 Oct; 49(10):4121-7. PMID: 16189088; PMCID: PMC1251526.
      140. Chokephaibulkit K, Plipat N, Cressey TR, Frederix K, Phongsamart W, Capparelli E, Kolladarungkri T, Vanprapar N. Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination of stavudine, lamivudine and nevirapine. AIDS. 2005 Sep 23; 19(14):1495-9. PMID: 16135903.
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      141. Shapiro RL, Holland DT, Capparelli E, Lockman S, Thior I, Wester C, Stevens L, Peter T, Essex M, Connor JD, Mirochnick M. Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment. J Infect Dis. 2005 Sep 01; 192(5):720-7. PMID: 16088821.
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      142. Pau AK, Moodley NK, Holland DT, Fomundam H, Matchaba GU, Capparelli E. Instability of lopinavir/ritonavir capsules at ambient temperatures in sub-Saharan Africa: relevance to WHO antiretroviral guidelines. AIDS. 2005 Jul 22; 19(11):1233-4. PMID: 15990580.
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      143. Capparelli E, Hochwald C, Rasmussen M, Parham A, Bradley J, Moya F. Population pharmacokinetics of cefepime in the neonate. Antimicrob Agents Chemother. 2005 Jul; 49(7):2760-6. PMID: 15980347; PMCID: PMC1168671.
      144. Kovacs A, Montepiedra G, Carey V, Pahwa S, Weinberg A, Frenkel L, Capparelli E, Mofenson L, Smith E, McIntosh K, Burchett SK. Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response. J Infect Dis. 2005 Jul 15; 192(2):296-302. PMID: 15962224.
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      145. Capparelli E, Holland D, Okamoto C, Gragg B, Durelle J, Marquie-Beck J, van den Brande G, Ellis R, Letendre S. Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV. AIDS. 2005 Jun 10; 19(9):949-52. PMID: 15905676.
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      146. Mirochnick M, Stek A, Acevedo M, Keller M, Holland D, Capparelli E, Connor J, Huang S, Hughes M, Watts H, Mofenson L, Bryson Y. Safety and pharmacokinetics of nelfinavir coadministered with zidovudine and lamivudine in infants during the first 6 weeks of life. J Acquir Immune Defic Syndr. 2005 Jun 01; 39(2):189-94. PMID: 15905735.
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      147. Capparelli E, Letendre SL, Ellis RJ, Patel P, Holland D, McCutchan JA. Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid. Antimicrob Agents Chemother. 2005 Jun; 49(6):2504-6. PMID: 15917556; PMCID: PMC1140502.
      148. Kovacs A, Cowles MK, Britto P, Capparelli E, Fowler MG, Moye J, McIntosh K, Rathore MH, Pitt J, Husson RN. Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life. Pediatr Infect Dis J. 2005 Jun; 24(6):503-9. PMID: 15933559.
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      149. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli E, Carlo WA, Hummel P, Lantos J, Johnston CC, Lehr VT, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005 Jun; 27(6):814-43. PMID: 16117988.
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      150. Capparelli E, Reed MD, Bradley JS, Kearns GL, Jacobs RF, Damle BD, Blumer JL, Grasela DM. Pharmacokinetics of gatifloxacin in infants and children. Antimicrob Agents Chemother. 2005 Mar; 49(3):1106-12. PMID: 15728910; PMCID: PMC549226.
      151. Cressey TR, Jourdain G, Lallemant MJ, Kunkeaw S, Jackson JB, Musoke P, Capparelli E, Mirochnick M. Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1. J Acquir Immune Defic Syndr. 2005 Mar 01; 38(3):283-8. PMID: 15735445.
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      152. Capparelli E, Rakhmanina N, Mirochnick M. Pharmacotherapy of perinatal HIV. Semin Fetal Neonatal Med. 2005 Apr; 10(2):161-75. PMID: 15701581.
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      153. Yasuda JM, Miller C, Currier JS, Forthal DN, Kemper CA, Beall GN, Tilles JG, Capparelli E, McCutchan JA, Haubrich RH. The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patients. Antivir Ther. 2004 Oct; 9(5):753-61. PMID: 15535413.
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      154. Mirochnick M, Capparelli E. Pharmacokinetics of antiretrovirals in pregnant women. Clin Pharmacokinet. 2004; 43(15):1071-87. PMID: 15568888.
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      155. Grundman M, Capparelli E, Kim HT, Morris JC, Farlow M, Rubin EH, Heidebrink J, Hake A, Ho G, Schultz AN, Schafer K, Houston W, Thomas R, Thal LJ. A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin) in mild Alzheimer's disease patients. Life Sci. 2003 Jun 20; 73(5):539-53. PMID: 12770610.
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      156. Ette EI, Williams PJ, Kim YH, Lane JR, Liu MJ, Capparelli E. Model appropriateness and population pharmacokinetic modeling. J Clin Pharmacol. 2003 Jun; 43(6):610-23. PMID: 12817524.
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      157. Abzug MJ, Cloud G, Bradley J, Sánchez PJ, Romero J, Powell D, Lepow M, Mani C, Capparelli E, Blount S, Lakeman F, Whitley RJ, Kimberlin DW. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J. 2003 Apr; 22(4):335-41. PMID: 12690273.
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      158. Capparelli E, Englund JA, Connor JD, Spector SA, McKinney RE, Palumbo P, Baker CJ. Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children. J Clin Pharmacol. 2003 Feb; 43(2):133-40. PMID: 12616665.
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      159. Best BM, Burns JC, DeVincenzo J, Phelps SJ, Blumer JL, Wilson JT, Capparelli E, Connor JD. Pharmacokinetic and tolerability assessment of a pediatric oral formulation of pentoxifylline in kawasaki disease. Curr Ther Res Clin Exp. 2003 Feb; 64(2):96-115. PMID: 24944359; PMCID: PMC4053025.
      160. Capparelli E, Mirochnick M, Dankner WM, Blanchard S, Mofenson L, McSherry GD, Gay H, Ciupak G, Smith B, Connor JD. Pharmacokinetics and tolerance of zidovudine in preterm infants. J Pediatr. 2003 Jan; 142(1):47-52. PMID: 12520254.
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      161. Grundman M, Farlow M, Peavy G, Kim HT, Capparelli E, Schultz AN, Salmon DP, Ferris SH, Mobs R, Thomas RG, Schafer K, Campbell K, Hake AM, Schoos B, Thal LJ. A phase I study of AIT-082 in healthy elderly volunteers. J Mol Neurosci. 2002 Jun; 18(3):283-93. PMID: 12059047.
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      162. Capparelli E, Lane JR, Romanowski GL, McFeely EJ, Murray W, Sousa P, Kildoo C, Connor JD. The influences of renal function and maturation on vancomycin elimination in newborns and infants. J Clin Pharmacol. 2001 Sep; 41(9):927-34. PMID: 11549096.
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      163. Capparelli E, Sullivan JL, Mofenson L, Smith E, Graham B, Britto P, Becker MI, Holland D, Connor JD, Luzuriaga K. Pharmacokinetics of nelfinavir in human immunodeficiency virus-infected infants. Pediatr Infect Dis J. 2001 Aug; 20(8):746-51. PMID: 11734735.
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      164. Mirochnick M, Cooper E, Capparelli E, McIntosh K, Lindsey J, Xu J, Jacobus D, Mofenson L, Bonagura VR, Nachman S, Yogev R, Sullivan JL, Spector SA. Population pharmacokinetics of dapsone in children with human immunodeficiency virus infection. Clin Pharmacol Ther. 2001 Jul; 70(1):24-32. PMID: 11452241.
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      165. Lemire J, Capparelli E, Benador N, Grimm P, Macdonald D, Reznik V. Neoral pharmacokinetics in Latino and Caucasian pediatric renal transplant recipients. Pediatr Nephrol. 2001 Apr; 16(4):311-4. PMID: 11354772.
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      166. Williams PJ, Lane JR, Turkel CC, Capparelli E, Dziewanowska Z, Fox AW. Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model. J Clin Pharmacol. 2001 Mar; 41(3):259-67. PMID: 11269566.
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      167. Frenkel LM, Capparelli E, Dankner WM, Xu J, Smith IL, Ballow A, Culnane M, Read JS, Thompson M, Mohan KM, Shaver A, Robinson CA, Stempien MJ, Burchett SK, Melvin AJ, Borkowsky W, Petru A, Kovacs A, Yogev R, Goldsmith J, McFarland EJ, Spector SA. Oral ganciclovir in children: pharmacokinetics, safety, tolerance, and antiviral effects. The Pediatric AIDS Clinical Trials Group. J Infect Dis. 2000 Dec; 182(6):1616-24. PMID: 11069232.
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      168. Kearns GL, Bradley JS, Jacobs RF, Capparelli E, James LP, Johnson KM, Abdel-Rahman SM. Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network. Pediatr Infect Dis J. 2000 Sep; 19(9):833-9. PMID: 11001105.
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      169. Letendre SL, Capparelli E, Ellis RJ, McCutchan JA. Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group. Antimicrob Agents Chemother. 2000 Aug; 44(8):2173-5. PMID: 10898694; PMCID: PMC90032.
      170. Bradley JS, Kearns GL, Reed MD, Capparelli E, Vincent J. Pharmacokinetics of a fluoronaphthyridone, trovafloxacin (CP 99,219), in infants and children following administration of a single intravenous dose of alatrofloxacin. Antimicrob Agents Chemother. 2000 May; 44(5):1195-9. PMID: 10770751; PMCID: PMC89844.
      171. Ellis RJ, Gamst AC, Capparelli E, Spector SA, Hsia K, Wolfson T, Abramson I, Grant I, McCutchan JA. Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources. Neurology. 2000 Feb 22; 54(4):927-36. PMID: 10690988.
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      172. Mirochnick M, Capparelli E, Connor J. Pharmacokinetics of zidovudine in infants: a population analysis across studies. Clin Pharmacol Ther. 1999 Jul; 66(1):16-24. PMID: 10430105.
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      173. Burns JC, Capparelli E, Brown JA, Newburger JW, Glode MP. Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group. Pediatr Infect Dis J. 1998 Dec; 17(12):1144-8. PMID: 9877364.
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      174. Lemire J, Capparelli E, MacDonald D, Benador N, Reznik VM, Mendoza SA, Griswold WR. Estimated area-under-the-curve monitoring of Neoral in a stable pediatric renal transplant population: one-year experience. Transplant Proc. 1998 Aug; 30(5):1983-4. PMID: 9723361.
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      175. Dengler LD, Capparelli E, Bastian JF, Bradley DJ, Glode MP, Santa S, Newburger JW, Baker AL, Matsubara T, Burns JC. Cerebrospinal fluid profile in patients with acute Kawasaki disease. Pediatr Infect Dis J. 1998 Jun; 17(6):478-81. PMID: 9655538.
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      176. Ting EC, Capparelli E, Billman GF, Lavine JE, Matsubara T, Burns JC. Elevated gamma-glutamyltransferase concentrations in patients with acute Kawasaki disease. Pediatr Infect Dis J. 1998 May; 17(5):431-2. PMID: 9613663.
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      177. Mirochnick M, Capparelli E, Dankner W, Sperling RS, van Dyke R, Spector SA. Zidovudine pharmacokinetics in premature infants exposed to human immunodeficiency virus. Antimicrob Agents Chemother. 1998 Apr; 42(4):808-12. PMID: 9559787; PMCID: PMC105546.
      178. Taskintuna I, Rahhal FM, Capparelli E, Cundy KC, Freeman WR. Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis. J Ocul Pharmacol Ther. 1998 Apr; 14(2):147-51. PMID: 9572540.
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      179. Mueller AJ, Jian G, Banker AS, Rahhal FM, Capparelli E, Freeman WR. The effect of deep posterior subtenon injection of corticosteroids on intraocular pressure. Am J Ophthalmol. 1998 Feb; 125(2):158-63. PMID: 9467440.
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      180. Bakshi SS, Britto P, Capparelli E, Mofenson L, Fowler MG, Rasheed S, Schoenfeld D, Zimmer B, Frank Y, Yogev R, Jimenez E, Salgo M, Boone G, Pahwa SG. Evaluation of pharmacokinetics, safety, tolerance, and activity of combination of zalcitabine and zidovudine in stable, zidovudine-treated pediatric patients with human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 190 Team. J Infect Dis. 1997 May; 175(5):1039-50. PMID: 9129064.
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      181. Williams PJ, Lane JR, Capparelli E, Kim YH, Coleman R. Direct comparison of three methods for predicting digoxin concentrations. Pharmacotherapy. 1996 Nov-Dec; 16(6):1085-92. PMID: 8947982.
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      182. Yuen GJ, Drusano GL, Fletcher C, Capparelli E, Connor JD, Lalezari JP, Drew L, Follansbee S, Busch D, Jacobson M. Population differences in ganciclovir clearance as determined by nonlinear mixed-effects modelling. Antimicrob Agents Chemother. 1995 Oct; 39(10):2350-2. PMID: 8619596; PMCID: PMC162943.
      183. Arevalo JF, Gonzalez C, Capparelli E, Kirsch LS, Garcia RF, Quiceno JI, Connor JD, Gambertoglio J, Bergeron-Lynn G, Freeman WR. Intravitreous and plasma concentrations of ganciclovir and foscarnet after intravenous therapy in patients with AIDS and cytomegalovirus retinitis. J Infect Dis. 1995 Oct; 172(4):951-6. PMID: 7561215.
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      184. Wu LR, Capparelli E, Connor JD. Therapy of pediatric AIDS. Curr Opin Pediatr. 1995 Apr; 7(2):214-9. PMID: 7787939.
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      185. García RF, Flores-Aguilar M, Quiceno JI, Capparelli E, Munguia D, Kuppermann BD, Arevalo F, Freeman WR. Results of rhegmatogenous retinal detachment repair in cytomegalovirus retinitis with and without scleral buckling. Ophthalmology. 1995 Feb; 102(2):236-45. PMID: 7862412.
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      186. Kim JW, el-Haig W, Capparelli E, Besen G, Connor JD, Freeman WR. Effect of partial retinal destruction and gliosis on the intravitreal pharmacokinetics of HPMPC. Retina. 1995; 15(6):513-7. PMID: 8747447.
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      187. Capparelli E. Pharmacokinetic considerations in the adolescent: non-cytochrome P450 metabolic pathways. J Adolesc Health. 1994 Dec; 15(8):641-7. PMID: 7696284.
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      188. Brodsky MA, Orlov MV, Capparelli E, Allen BJ, Iseri LT, Ginkel M, Orlov YS. Magnesium therapy in new-onset atrial fibrillation. Am J Cardiol. 1994 Jun 15; 73(16):1227-9. PMID: 8203347.
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      189. Kuppermann BD, Flores-Aguilar M, Quiceno JI, Capparelli E, Levi L, Munguia D, Freeman WR. A masked prospective evaluation of outcome parameters for cytomegalovirus-related retinal detachment surgery in patients with acquired immune deficiency syndrome. Ophthalmology. 1994 Jan; 101(1):46-55. PMID: 8302563.
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      190. Kuppermann BD, Quiceno JI, Flores-Aguilar M, Connor JD, Capparelli E, Sherwood CH, Freeman WR. Intravitreal ganciclovir concentration after intravenous administration in AIDS patients with cytomegalovirus retinitis: implications for therapy. J Infect Dis. 1993 Dec; 168(6):1506-9. PMID: 8245536.
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      191. Flores-Aguilar M, Kuppermann BD, Quiceno JI, Dankner WM, Wolf DG, Capparelli E, Connor JD, Sherwood CH, Fullerton S, Gambertoglio JG. Pathophysiology and treatment of clinically resistant cytomegalovirus retinitis. Ophthalmology. 1993 Jul; 100(7):1022-31. PMID: 8391674.
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      192. Brodsky MA, Chough SP, Allen BJ, Capparelli E, Orlov MV, Caudillo G. Adjuvant metoprolol improves efficacy of class I antiarrhythmic drugs in patients with inducible sustained monomorphic ventricular tachycardia. Am Heart J. 1992 Sep; 124(3):629-35. PMID: 1514490.
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      193. Capparelli E. New calcium-channel blockers: improved therapy? Clin Pharm. 1992 Jun; 11(6):549-52. PMID: 1600688.
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      194. Dolnak DR, Munguia D, Wiley CA, De Clercq E, Bergeron-Lynn GL, Boscher C, Connor JD, Sherwood C, Capparelli E, Armani R. Lack of retinal toxicity of the anticytomegalovirus drug (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine. Invest Ophthalmol Vis Sci. 1992 Apr; 33(5):1557-63. PMID: 1559752.
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      195. Quiceno JI, Capparelli E, Sadun AA, Munguia D, Grant I, Listhaus A, Crapotta J, Lambert B, Freeman WR. Visual dysfunction without retinitis in patients with acquired immunodeficiency syndrome. Am J Ophthalmol. 1992 Jan 15; 113(1):8-13. PMID: 1728151.
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      196. Capparelli E, Stevens RC, Chow MS, Izard M, Wills RJ. Rimantadine pharmacokinetics in healthy subjects and patients with end-stage renal failure. Clin Pharmacol Ther. 1988 May; 43(5):536-41. PMID: 3365917.
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      197. Capparelli E, DiPersio DM, Zhao H, Kluger J, Chow MS. Clinical pharmacokinetics of controlled-release disopyramide in patients with cardiac arrhythmias. J Clin Pharmacol. 1988 Apr; 28(4):306-11. PMID: 3392228.
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      198. Capparelli E, Kluger J, Regnier JC, Chow MS. Clinical and electrophysiologic effects of flecainide in patients with refractory ventricular tachycardia. J Clin Pharmacol. 1988 Mar; 28(3):268-75. PMID: 3129456.
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