Edmund Capparelli

Title(s)Recall Faculty, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH P50HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH U54HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Academic Training in Therapeutic Advancement for Child Health (ATTACH)
    NIH T32HD087978May 1, 2016 - Apr 30, 2026
    Role: Principal Investigator
    Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy
    NIH U54HD071600Sep 26, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Pediatric Pharmacology Research Unit Network
    NIH U10HD031318Jan 1, 1994 - Dec 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS. JCI Insight. 2024 Apr 08; 9(7). Awan SF, Pegu A, Strom L, Carter CA, Hendel CS, Holman LA, Costner PJ, Trofymenko O, Dyer R, Gordon IJ, Rothwell RSS, Hickman SP, Conan-Cibotti M, Doria-Rose NA, Lin BC, O'Connell S, Narpala SR, Almasri CG, Liu C, Ko S, Kwon YD, Namboodiri AM, Pandey JP, Arnold FJ, Carlton K, Gall JG, Kwong PD, Capparelli EV, Bailer RT, McDermott AB, Chen GL, Koup RA, Mascola JR, Coates EE, Ledgerwood JE, Gaudinski MR, VRC 610 study team. PMID: 38587079.
      View in: PubMed   Mentions:
    2. Safety and pharmacokinetics of oral and long-acting injectable cabotegravir or long-acting injectable rilpivirine in virologically suppressed adolescents with HIV (IMPAACT 2017/MOCHA): a phase 1/2, multicentre, open-label, non-comparative, dose-finding study. Lancet HIV. 2024 Apr; 11(4):e211-e221. Gaur AH, Capparelli EV, Calabrese K, Baltrusaitis K, Marzinke MA, McCoig C, Van Solingen-Ristea RM, Mathiba SR, Adeyeye A, Moye JH, Heckman B, Lowenthal ED, Ward S, Milligan R, Samson P, Best BM, Harrington CM, Ford SL, Huang J, Crauwels H, Vandermeulen K, Agwu AL, Smith-Anderson C, Camacho-Gonzalez A, Ounchanum P, Kneebone JL, Townley E, Bolton Moore C, IMPAACT 2017 Collaborators, IMPAACT 2017 Team. PMID: 38538160.
      View in: PubMed   Mentions:    Fields:    Translation:CTClinical Trials
    3. Paediatric abacavir-lamivudine fixed-dose dispersible tablets and ritonavir-boosted lopinavir granules in neonates exposed to HIV (PETITE study): an open-label, two-stage, single-arm, phase 1/2, pharmacokinetic and safety trial. Lancet HIV. 2024 Feb; 11(2):e86-e95. Bekker A, Salvadori N, Rabie H, du Toit S, Than-In-At K, Groenewald M, Cressey R, Nielsen J, Capparelli EV, Lallemant M, Cotton MF, Cressey TR, PETITE-ABC/3TC-LPVr Study Team. PMID: 38296364.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsCTClinical Trials
    4. Safety and Pharmacokinetics of Lopinavir/Ritonavir Oral Solution in Preterm and Term Infants Starting Before 3 Months of Age. Pediatr Infect Dis J. 2024 Apr 01; 43(4):355-360. Bekker A, Yang J, Wang J, Cotton MF, Cababasay M, Wiesner L, Moye J, Browning R, Nakwa FL, Rabie H, Violari A, Mirochnick M, Cressey TR, Capparelli EV. PMID: 38190642; PMCID: PMC10939833.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    5. HIV-1 reservoir size after neonatal antiretroviral therapy and the potential to evaluate antiretroviral-therapy-free remission (IMPAACT P1115): a phase 1/2 proof-of-concept study. Lancet HIV. 2024 Jan; 11(1):e20-e30. Persaud D, Bryson Y, Nelson BS, Tierney C, Cotton MF, Coletti A, Jao J, Spector SA, Mirochnick M, Capparelli EV, Costello D, Szewczyk J, Nicodimus N, Stranix-Chibanda L, Kekitiinwa AR, Korutaro V, Reding C, Carrington MN, Majji S, Yin DE, Jean-Philippe P, Chadwick EG. PMID: 38061376.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsCTClinical Trials
    6. Brief Report: Dolutegravir Plasma Protein Binding and Unbound Concentrations During Pregnancy and Postpartum. J Acquir Immune Defic Syndr. 2023 12 01; 94(4):332-336. Momper JD, Nikanjam M, Best BM, Mirochnick M, Capparelli EV, Cressey TR. PMID: 37884053; PMCID: PMC10686188.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Pharmacokinetics and safety of first-line tuberculosis drugs rifampin, isoniazid, ethambutol, and pyrazinamide during pregnancy and postpartum: results from IMPAACT P1026s. Antimicrob Agents Chemother. 2023 11 15; 67(11):e0073723. Van Schalkwyk M, Bekker A, Decloedt E, Wang J, Theron GB, Cotton MF, Eke AC, Cressey TR, Shapiro DE, Bacon K, Knowles K, George K, Browning R, Chakhtoura N, Rungruengthanakit K, Wiesner L, Capparelli EV, Stek AM, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team. PMID: 37882552; PMCID: PMC10648924.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants. Clin Pharmacokinet. 2023 11; 62(11):1611-1619. Yeung CHT, Bertrand KA, Best BM, Capparelli E, Chambers CD, Hajducek DM, Hamadeh A, Ito S, Momper JD, Edginton AN. PMID: 37735347; PMCID: PMC10659070.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV-negative women: study protocol for the randomised, placebo-controlled double-blinded, phase 2 CAPRISA 012C trial. BMJ Open. 2023 08 28; 13(8):e076843. Mahomed S, Garrett N, Potloane D, Sikazwe IT, Capparelli E, Harkoo I, Gengiah TN, Zuma NY, Osman F, Mansoor L, Archary D, Myeni N, Radebe P, Samsunder N, Doria-Rose N, Carlton K, Gama L, Koup RA, Narpala S, Serebryannyy L, Moore P, Williamson C, Pozzetto B, Hankins C, Morris L, Karim QA, Abdool Karim S. PMID: 37640457; PMCID: PMC10462944.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCTClinical Trials
    10. Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection. Clin Infect Dis. 2023 07 26; 77(2):272-279. Funderburg NT, Shive CL, Chen Z, Tatsuoka C, Bowman ER, Longenecker CT, McComsey GA, Clagett BM, Dorazio D, Freeman ML, Sieg SF, Moisi D, Anthony DD, Jacobson JM, Stein SL, Calabrese LH, Landay A, Flexner C, Crawford KW, Capparelli EV, Rodriguez B, Lederman MM. PMID: 37011013; PMCID: PMC10371305.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana. Sci Transl Med. 2023 07 05; 15(703):eadh0004. Shapiro RL, Ajibola G, Maswabi K, Hughes M, Nelson BS, Niesar A, Pretorius Holme M, Powis KM, Sakoi M, Batlang O, Moyo S, Mohammed T, Maphorisa C, Bennett K, Hu Z, Giguel F, Reeves JD, Reeves MA, Gao C, Yu X, Ackerman ME, McDermott A, Cooper M, Caskey M, Gama L, Jean-Philippe P, Yin DE, Capparelli EV, Lockman S, Makhema J, Kuritzkes DR, Lichterfeld M. PMID: 37406137; PMCID: PMC10683791.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    12. Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy. Clin Pharmacol Ther. 2023 08; 114(2):459-469. Mizuno K, Capparelli EV, Fukuda T, Dong M, Adamson PC, Blumer JL, Cnaan A, Clark PO, Reed MD, Shinnar S, Vinks AA, Glauser TA, Childhood Absence Epilepsy Study Group. PMID: 37316457.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates. Clin Pharmacokinet. 2023 08; 62(8):1105-1116. Tang BH, Zhang JY, Allegaert K, Hao GX, Yao BF, Leroux S, Thomson AH, Yu Z, Gao F, Zheng Y, Zhou Y, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Jacqz-Aigrain E, van den Anker J, Wu YE, Zhao W. PMID: 37300630.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Translating Clinical Pharmacology Data in Pregnancy to Evidence-Based Guideline Recommendations: Perspectives From the HIV Field. J Clin Pharmacol. 2023 06; 63 Suppl 1:S188-S196. Brooks KM, Scott RK, Best BM, Capparelli E, Momper JD. PMID: 37317495.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Variable Delta-9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics After Cannabis Smoking in Regular Users. Ther Drug Monit. 2023 10 01; 45(5):689-696. Liyanage M, Nikanjam M, Capparelli EV, Suhandynata RT, Fitzgerald RL, Marcotte TD, Grant I, Momper JD. PMID: 37199428.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    16. Brief Report: Long-Term Clinical, Immunologic, and Virologic Outcomes Among Early-Treated Children With HIV in Botswana: A Nonrandomized Controlled Clinical Trial. J Acquir Immune Defic Syndr. 2023 04 15; 92(5):393-398. Ajibola G, Maswabi K, Hughes MD, Bennett K, Pretorius-Holme M, Capparelli EV, Jean-Philippe P, Moyo S, Mohammed T, Batlang O, Sakoi M, Ricci L, Lockman S, Makhema J, Kuritzkes DR, Lichterfeld M, Shapiro RL. PMID: 36729692; PMCID: PMC10006291.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    17. Safety and pharmacokinetics of escalating doses of neutralising monoclonal antibody CAP256V2LS administered with and without VRC07-523LS in HIV-negative women in South Africa (CAPRISA 012B): a phase 1, dose-escalation, randomised controlled trial. Lancet HIV. 2023 04; 10(4):e230-e243. Mahomed S, Garrett N, Capparelli EV, Osman F, Mkhize NN, Harkoo I, Gengiah TN, Mansoor LE, Baxter C, Archary D, Yende-Zuma N, Samsunder N, Carlton K, Narpala S, McDermott AB, Doria-Rose NA, Moore PL, Morris L, Abdool Karim Q, Mascola JR, Abdool Karim SS. PMID: 37001964.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    18. Dosing of 3 Targeted Agents in Novel Drug Combinations Used at the Precision Medicine Clinic of the University of California San Diego. J Hematol Oncol Pharm. 2023 Feb; 13(1):19-25. Nikanjam M, Tinajero J, McGann M, Li J, Yang J, Shen F, Sicklick JK, Kato S, Capparelli E, Kurzrock R. PMID: 36998525; PMCID: PMC10054256.
      View in: PubMed   Mentions: 2  
    19. Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial. Lancet Infect Dis. 2023 05; 23(5):578-588. Lyke KE, Berry AA, Mason K, Idris AH, O'Callahan M, Happe M, Strom L, Berkowitz NM, Guech M, Hu Z, Castro M, Basappa M, Wang L, Low K, Holman LA, Mendoza F, Gordon IJ, Plummer SH, Trofymenko O, Strauss KS, Joshi S, Shrestha B, Adams M, Chagas AC, Murphy JR, Stein J, Hickman S, McDougal A, Lin B, Narpala SR, Vazquez S, Serebryannyy L, McDermott A, Gaudinski MR, Capparelli EV, Coates EE, Wu RL, Ledgerwood JE, Dropulic LK, Seder RA, VRC 612 Part C Study Team. PMID: 36708738; PMCID: PMC10121890.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCTClinical Trials
    20. Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic Approach. Ther Drug Monit. 2023 08 01; 45(4):539-545. Piscitelli J, Nikanjam M, Capparelli EV, Blaquera CL, Penzak SR, Nolin TD, Paine MF, Ma JD. PMID: 36645711; PMCID: PMC10123170.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    21. Physiologically-based pharmacokinetic modeling of remdesivir and its metabolites in pregnant women with COVID-19. CPT Pharmacometrics Syst Pharmacol. 2023 02; 12(2):148-153. Liu XI, Dallmann A, Brooks K, Best BM, Clarke DF, Mirochnick M, van den Anker JN, Capparelli EV, Momper JD. PMID: 36479969; PMCID: PMC9877749.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Potential of Long-Acting Products to Transform the Treatment and Prevention of Human Immunodeficiency Virus (HIV) in Infants, Children, and Adolescents. Clin Infect Dis. 2022 11 21; 75(Suppl 4):S562-S570. Abrams EJ, Capparelli E, Ruel T, Mirochnick M. PMID: 36410381; PMCID: PMC10200315.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Safety and Pharmacokinetics of Intravenous 10-1074 and VRC01LS in Young Children. J Acquir Immune Defic Syndr. 2022 10 01; 91(2):182-188. Capparelli EV, Ajibola G, Maswabi K, Holme MP, Bennett K, Powis KM, Moyo S, Mohammed T, Maphorisa C, Hughes MD, Seaton KE, Tomaras GD, Mosher S, Taylor A, O'Connell S, Narpala S, Mcdermott A, Caskey M, Gama L, Lockman S, Jean-Philippe P, Makhema J, Kuritzkes DR, Lichterfeld M, Shapiro RL, Tatelo Study Team. PMID: 36094485; PMCID: PMC10224771.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Influence of NAT2 Genotype and Maturation on Isoniazid Exposure in Low-Birth-Weight and Preterm Infants With or Without Human Immunodeficiency Virus (HIV) Exposure. Clin Infect Dis. 2022 09 29; 75(6):1037-1045. Béranger A, Bekker A, Solans BP, Cotton MF, Mirochnick M, Violari A, Wang J, Cababasay M, Wiesner L, Browning R, Moye J, Capparelli EV, Savic RM. PMID: 35134861; PMCID: PMC9522418.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. Safety and Pharmacokinetics of Monoclonal Antibodies VRC07-523LS and PGT121 Administered Subcutaneously for Human Immunodeficiency Virus Prevention. J Infect Dis. 2022 08 26; 226(3):510-520. Mahomed S, Garrett N, Capparelli EV, Osman F, Harkoo I, Yende-Zuma N, Gengiah TN, Archary D, Samsunder N, Baxter C, Mkhize NN, Modise T, Carlton K, McDermott A, Moore PL, Karim QA, Barouch DH, Fast PE, Mascola JR, Ledgerwood JE, Morris L, Abdool Karim SS. PMID: 35134995; PMCID: PMC9417124.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsCTClinical Trials
    26. Pediatric AIDS-Therapeutic Successes Built on a Foundation of Pediatric Clinical Pharmacology with Pharmacokinetic-Pharmacodynamic Modeling. J Pediatr Pharmacol Ther. 2022; 27(6):482-489. Capparelli EV. PMID: 36042957; PMCID: PMC9400182.
      View in: PubMed   Mentions:
    27. Maraviroc Population Pharmacokinetics Within the First 6 Weeks of Life. Pediatr Infect Dis J. 2022 11 01; 41(11):885-890. Liyanage M, Nikanjam M, McFadyen L, Vourvahis M, Rogg L, Moye J, Chadwick EG, Jean-Philippe P, Mirochnick M, Whitson K, Bradford S, Capparelli EV, Best BM. PMID: 35980827; PMCID: PMC9560968.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria. N Engl J Med. 2022 08 04; 387(5):397-407. Wu RL, Idris AH, Berkowitz NM, Happe M, Gaudinski MR, Buettner C, Strom L, Awan SF, Holman LA, Mendoza F, Gordon IJ, Hu Z, Campos Chagas A, Wang LT, Da Silva Pereira L, Francica JR, Kisalu NK, Flynn BJ, Shi W, Kong WP, O'Connell S, Plummer SH, Beck A, McDermott A, Narpala SR, Serebryannyy L, Castro M, Silva R, Imam M, Pittman I, Hickman SP, McDougal AJ, Lukoskie AE, Murphy JR, Gall JG, Carlton K, Morgan P, Seo E, Stein JA, Vazquez S, Telscher S, Capparelli EV, Coates EE, Mascola JR, Ledgerwood JE, Dropulic LK, Seder RA, VRC 614 Study Team. PMID: 35921449; PMCID: PMC9806693.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCTClinical Trials
    29. Advancing the prevention and treatment of HIV in children: priorities for research and development. Lancet HIV. 2022 09; 9(9):e658-e666. Penazzato M, Townsend CL, Sam-Agudu NA, Ruel TD, Archary M, Bekker A, Cressey TR, Colbers A, Sugandhi N, Rojo P, Rakhmanina N, Watkins M, Frigati L, Mukui I, Hafiz A, Vicari M, Capparelli EV, Abrams EJ, PADO-HIV 5 participants. PMID: 35863362.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Pharmacokinetics of Tenofovir Alafenamide With Boosted Protease Inhibitors in Pregnant and Postpartum Women Living With HIV: Results From IMPAACT P1026s. J Acquir Immune Defic Syndr. 2022 07 01; 90(3):343-350. Brooks KM, Pinilla M, Stek AM, Shapiro DE, Barr E, Febo IL, Paul ME, Deville JG, George K, Knowles K, Rungruengthanakit K, Browning R, Chakhtoura N, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team. PMID: 35195573; PMCID: PMC9203910.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Leveraging physiologically based pharmacokinetic modeling to optimize dosing for lopinavir/ritonavir with rifampin in pediatric patients. Pharmacotherapy. 2023 07; 43(7):638-649. Salerno SN, Capparelli EV, McIlleron H, Gerhart JG, Dumond JB, Kashuba ADM, Denti P, Gonzalez D. PMID: 35607886; PMCID: PMC9684348.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Impact of CYP2B6 genotype, tuberculosis therapy, and formulation on efavirenz pharmacokinetics in infants and children under 40 months of age. AIDS. 2022 03 15; 36(4):525-532. Nikanjam M, Tran L, Chadwick EG, Bwakura-Dangarembizi M, Bolton Moore C, Samson P, Spector SA, Chakhtoura N, Jean-Philippe P, Frenkel L, Zimmer B, Benns A, Libous J, Capparelli EV. PMID: 34873089; PMCID: PMC8881387.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Pharmacokinetics of Atazanavir Boosted With Cobicistat in Pregnant and Postpartum Women With HIV. J Acquir Immune Defic Syndr. 2022 03 01; 89(3):303-309. Momper JD, Wang J, Stek A, Shapiro DE, Powis KM, Paul ME, Badell ML, Browning R, Chakhtoura N, Denson K, Rungruengthanakit K, George K, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team. PMID: 34732682; PMCID: PMC8837686.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    34. Pharmacokinetics and Safety of the Abacavir/Lamivudine/Lopinavir/Ritonavir Fixed-Dose Granule Formulation (4-in-1) in Neonates: PETITE Study. J Acquir Immune Defic Syndr. 2022 03 01; 89(3):324-331. Bekker A, Rabie H, Salvadori N, du Toit S, Than-In-At K, Groenewald M, Andrieux-Meyer I, Kumar M, Cressey R, Nielsen J, Capparelli E, Lallemant M, Cotton MF, Cressey TR, PETITE Study Team. PMID: 34855626; PMCID: PMC8826609.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    35. Tumor Genomic Profiling and Ex Vivo Drug Sensitivity Testing for Pediatric Leukemia and Lymphoma Patients. J Pediatr Pharmacol Ther. 2022; 27(2):123-131. Eaton A, Wong V, Schiff D, Anderson E, Ding H, Capparelli EV, Determan D, Kuo DJ. PMID: 35241983; PMCID: PMC8837212.
      View in: PubMed   Mentions:
    36. Optimizing Dolutegravir Initiation in Neonates Using Population Pharmacokinetic Modeling and Simulation. J Acquir Immune Defic Syndr. 2022 01 01; 89(1):108-114. Piscitelli J, Nikanjam M, Best BM, Acosta E, Mirochnick M, Clarke DF, Capparelli EV, Momper JD. PMID: 34629412; PMCID: PMC8665018.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Anakinra Treatment in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysms: A Phase I/IIa Trial. J Pediatr. 2022 04; 243:173-180.e8. Yang J, Jain S, Capparelli EV, Best BM, Son MB, Baker A, Newburger JW, Franco A, Printz BF, He F, Shimizu C, Hoshino S, Bainto E, Moreno E, Pancheri J, Burns JC, Tremoulet AH. PMID: 34953816.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    38. Quantitative Analysis of the Phase Transition Mechanism Underpinning the Systemic Self-Assembly of a Mechanopharmaceutical Device. Pharmaceutics. 2021 Dec 22; 14(1). Dunne S, Willmer AR, Swanson R, Almeida D, Ammerman NC, Stringer KA, Capparelli EV, Rosania GR. PMID: 35056910; PMCID: PMC8780429.
      View in: PubMed   Mentions: 4  
    39. An Adaptive Biosystems Engineering Approach towards Modeling the Soluble-to-Insoluble Phase Transition of Clofazimine. Pharmaceutics. 2021 Dec 22; 14(1). Willmer AR, Dunne S, Swanson R, Almeida D, Ammerman NC, Stringer KA, Capparelli EV, Rosania GR. PMID: 35056913; PMCID: PMC8779763.
      View in: PubMed   Mentions: 3  
    40. Abacavir dosing in neonates from birth to 3 months of life: a population pharmacokinetic modelling and simulation study. Lancet HIV. 2022 01; 9(1):e24-e31. Bekker A, Capparelli EV, Violari A, Cotton MF, Cababasay M, Wang J, Mathiba R, Wiesner L, Wiznia A, Samson P, Browning R, Moye J, Nakwa FL, Decloedt E, Rabie H, Mirochnick M, Cressey TR, IMPAACT P1106 team. PMID: 34883066; PMCID: PMC8760861.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. Safety, Tolerability, and Pharmacokinetics of a Long-Acting Broadly Neutralizing Human Immunodeficiency Virus Type 1 (HIV-1) Monoclonal Antibody VRC01LS in HIV-1-Exposed Newborn Infants. J Infect Dis. 2021 12 01; 224(11):1916-1924. McFarland EJ, Cunningham CK, Muresan P, Capparelli EV, Perlowski C, Morgan P, Smith B, Hazra R, Purdue L, Harding PA, Theron G, Mujuru H, Agwu A, Purswani M, Rathore MH, Flach B, Taylor A, Lin BC, McDermott AB, Mascola JR, Graham BS, International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1112 Team. PMID: 34009371; PMCID: PMC8643399.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsPHPublic Health
    42. One dose does not fit all: revising the WHO paediatric dosing tool to include the non-linear effect of body size and maturation. Lancet Child Adolesc Health. 2022 01; 6(1):9-10. Denti P, Wasmann RE, Francis J, McIlleron H, Sugandhi N, Cressey TR, Mirochnick M, Capparelli EV, Penazzato M, WHO Pediatric Antiretroviral Working Group. PMID: 34678142.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development. Front Pediatr. 2021; 9:721059. Zhao S, Gockenbach M, Grimstein M, Sachs HC, Mirochnick M, Struble K, Belew Y, Wang J, Capparelli EV, Best BM, Johnson T, Momper JD, Maharaj AR. PMID: 34722417; PMCID: PMC8550258.
      View in: PubMed   Mentions: 3  
    44. Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients. Microbiol Spectr. 2021 10 31; 9(2):e0046021. Shoji K, Saito J, Nakagawa H, Funaki T, Fukuda A, Sakamoto S, Kasahara M, Momper JD, Capparelli EV, Miyairi I. PMID: 34612690; PMCID: PMC8510181.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests. Pharmacogenomics J. 2022 02; 22(1):25-32. Zhu GD, Whitley P, LaRue L, Adkins B, Dawson E, Huskey A, Capparelli EV, Del Tredici AL. PMID: 34480108.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    46. Interactions between etonogestrel-releasing contraceptive implant and 3 antiretroviral regimens. Contraception. 2022 01; 105:67-74. Kreitchmann R, Stek A, Best BM, Capparelli E, Wang J, Shapiro D, Chakhtoura N, Mirochnick M, Eke AC, IMPAACT P1026s protocol team. PMID: 34407424; PMCID: PMC8678338.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. A Monoclonal Antibody for Malaria Prevention. N Engl J Med. 2021 08 26; 385(9):803-814. Gaudinski MR, Berkowitz NM, Idris AH, Coates EE, Holman LA, Mendoza F, Gordon IJ, Plummer SH, Trofymenko O, Hu Z, Campos Chagas A, O'Connell S, Basappa M, Douek N, Narpala SR, Barry CR, Widge AT, Hicks R, Awan SF, Wu RL, Hickman S, Wycuff D, Stein JA, Case C, Evans BP, Carlton K, Gall JG, Vazquez S, Flach B, Chen GL, Francica JR, Flynn BJ, Kisalu NK, Capparelli EV, McDermott A, Mascola JR, Ledgerwood JE, Seder RA, VRC 612 Study Team. PMID: 34379916; PMCID: PMC8579034.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCTClinical Trials
    48. Lopinavir and tenofovir interaction observed in non-pregnant adults altered during pregnancy. J Clin Pharm Ther. 2021 Oct; 46(5):1459-1464. Mulligan N, Salama E, Momper JD, Capparelli EV, Stek A, Chakhtoura N, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team. PMID: 34254323; PMCID: PMC8448937.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. Pharmacokinetics of darunavir and cobicistat in pregnant and postpartum women with HIV. AIDS. 2021 07 01; 35(8):1191-1199. Momper JD, Wang J, Stek A, Shapiro DE, Scott GB, Paul ME, Febo IL, Burchett S, Smith E, Chakhtoura N, Denson K, Rungruengthanakit K, George K, Yang DZ, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team. PMID: 34076612; PMCID: PMC8173003.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    50. Simulation-Based Pharmacokinetics Sampling Design for Evaluating Correlates of Prevention Efficacy of Passive HIV Monoclonal Antibody Prophylaxis. Stat Biopharm Res. 2022; 14(4):611-625. Zhang L, Gilbert PB, Capparelli E, Huang Y. PMID: 36684526; PMCID: PMC9856202.
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    51. Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction. Clin Pharmacokinet. 2021 11; 60(11):1435-1448. Tang BH, Guan Z, Allegaert K, Wu YE, Manolis E, Leroux S, Yao BF, Shi HY, Li X, Huang X, Wang WQ, Shen AD, Wang XL, Wang TY, Kou C, Xu HY, Zhou Y, Zheng Y, Hao GX, Xu BP, Thomson AH, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Burggraaf J, Jacqz-Aigrain E, van den Anker J, Zhao W. PMID: 34041714.
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    52. S-warfarin limited sampling strategy with a population pharmacokinetic approach to estimate exposure and cytochrome P450 (CYP) 2C9 activity in healthy adults. Eur J Clin Pharmacol. 2021 Sep; 77(9):1349-1356. Tran L, Nikanjam M, Capparelli EV, Bertino JS, Nafziger AN, Kashuba ADM, Turpault S, Ma JD. PMID: 33754183.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies. Pharmacotherapy. 2021 04; 41(4):405-420. Silmore LH, Willmer AR, Capparelli EV, Rosania GR. PMID: 33583102; PMCID: PMC8485703.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    54. Pharmacokinetics of tenofovir alafenamide with and without cobicistat in pregnant and postpartum women living with HIV. AIDS. 2021 03 01; 35(3):407-417. Brooks KM, Momper JD, Pinilla M, Stek AM, Barr E, Weinberg A, Deville JG, Febo IL, Cielo M, George K, Denson K, Rungruengthanakit K, Shapiro DE, Smith E, Chakhtoura N, Rooney JF, Haubrich R, Espina R, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team. PMID: 33252495; PMCID: PMC8238253.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    55. Population Pharmacokinetics of Tenofovir in Pregnant and Postpartum Women Using Tenofovir Disoproxil Fumarate. Antimicrob Agents Chemother. 2021 02 17; 65(3). Eke AC, Shoji K, Best BM, Momper JD, Stek AM, Cressey TR, Mirochnick M, Capparelli EV. PMID: 33318014; PMCID: PMC8092509.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    56. Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life. Clin Infect Dis. 2021 02 01; 72(3):388-393. Maswabi K, Ajibola G, Bennett K, Capparelli EV, Jean-Philippe P, Moyo S, Mohammed T, Batlang O, Sakoi M, Lockman S, Makhema J, Lichterfeld M, Kuritzkes DR, Hughes MD, Shapiro RL. PMID: 31927562; PMCID: PMC7850532.
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    57. Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol for the first-in-human CAPRISA 012B phase I clinical trial. BMJ Open. 2020 11 26; 10(11):e042247. Mahomed S, Garrett N, Karim QA, Zuma NY, Capparelli E, Baxter C, Gengiah T, Archary D, Samsunder N, Doria-Rose N, Moore P, Williamson C, Barouch DH, Fast PE, Pozzetto B, Hankins C, Carlton K, Ledgerwood J, Morris L, Mascola J, Abdool Karim S. PMID: 33243815; PMCID: PMC7692975.
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    58. Pharmacokinetics and safety of early nevirapine-based antiretroviral therapy for neonates at high risk for perinatal HIV infection: a phase 1/2 proof of concept study. Lancet HIV. 2021 03; 8(3):e149-e157. Ruel TD, Capparelli EV, Tierney C, Nelson BS, Coletti A, Bryson Y, Cotton MF, Spector SA, Mirochnick M, LeBlanc R, Reding C, Zimmer B, Persaud D, Bwakura-Dangarembizi M, Naidoo KL, Hazra R, Jean-Philippe P, Chadwick EG. PMID: 33242457; PMCID: PMC7933083.
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    59. Optimizing Pharmacology Studies in Pregnant and Lactating Women Using Lessons From HIV: A Consensus Statement. Clin Pharmacol Ther. 2021 07; 110(1):36-48. Eke AC, Olagunju A, Momper J, Penazzato M, Abrams EJ, Best BM, Capparelli EV, Bekker A, Belew Y, Kiser JJ, Struble K, Taylor G, Waitt C, Mirochnick M, Cressey TR, Colbers A, participants of the WHO-IMPAACT workshop on “Approaches to Optimize and Accelerate Pharmacokinetic S. PMID: 32930408; PMCID: PMC8167886.
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    60. Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach. Clin Pharmacol Ther. 2021 01; 109(1):184-192. Li J, Nikanjam M, Cunningham CK, McFarland EJ, Coates EE, Houser KV, Lin BC, McDermott AB, Flach B, Gama L, Koup RA, Graham BS, Mascola JR, Ledgerwood JE, Capparelli EV. PMID: 32866318; PMCID: PMC7902301.
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    61. Intraperitoneal vancomycin for peritoneal dialysis-associated peritonitis in children: Evaluation of loading dose guidelines. Perit Dial Int. 2021 03; 41(2):202-208. Hennessy K, Capparelli EV, Romanowski G, Alejandro L, Murray W, Benador N. PMID: 32862775.
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    62. Short-course Benznidazole treatment to reduce Trypanosoma cruzi parasitic load in women of reproductive age (BETTY): a non-inferiority randomized controlled trial study protocol. Reprod Health. 2020 Aug 24; 17(1):128. Cafferata ML, Toscani MA, Althabe F, Belizán JM, Bergel E, Berrueta M, Capparelli EV, Ciganda Á, Danesi E, Dumonteil E, Gibbons L, Gulayin PE, Herrera C, Momper JD, Rossi S, Shaffer JG, Schijman AG, Sosa-Estani S, Stella CB, Klein K, Buekens P. PMID: 32831069; PMCID: PMC7446054.
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    63. Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women Infected with Schistosoma japonicum. Antimicrob Agents Chemother. 2020 08 20; 64(9). Bustinduy AL, Kolamunnage-Dona R, Mirochnick MH, Capparelli EV, Tallo V, Acosta LP, Olveda RM, Friedman JF, Hope WW. PMID: 32631820; PMCID: PMC7449211.
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    64. Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing Human Immunodeficiency Virus (HIV)-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants. J Infect Dis. 2020 07 23; 222(4):628-636. Cunningham CK, McFarland EJ, Morrison RL, Capparelli EV, Safrit JT, Mofenson LM, Mathieson B, Valentine ME, Perlowski C, Smith B, Hazra R, Purdue L, Muresan P, Harding PA, Mbengeranwa T, Robinson LG, Wiznia A, Theron G, Lin B, Bailer RT, Mascola JR, Graham BS, IMPAACT P1112 team. PMID: 31681963; PMCID: PMC7377284.
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    65. A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain. Pain. 2020 06; 161(6):1341-1349. Gould HM, Atkinson JH, Chircop-Rollick T, D'Andrea J, Garfin S, Patel SM, Funk SD, Capparelli EV, Penzien DB, Wallace M, Weickgenanta AL, Slater M, Rutledge T. PMID: 32068667.
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    66. Meropenem pharmacokinetics during extracorporeal membrane oxygenation and continuous haemodialysis: a case report. J Glob Antimicrob Resist. 2020 09; 22:651-655. Saito J, Shoji K, Oho Y, Aoki S, Matsumoto S, Yoshida M, Nakamura H, Kaneko Y, Hayashi T, Yamatani A, Capparelli E, Miyairi I. PMID: 32417590.
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    67. Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment. J Pediatric Infect Dis Soc. 2020 Apr 30; 9(2):261-264. Higa N, Pelz A, Birch D, Beck IA, Sils T, Samson P, Bwakura-Dangarembizi M, Bolton-Moore C, Capparelli E, Chadwick E, Frenkel LM. PMID: 31194860; PMCID: PMC7192398.
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    68. Darunavir Pharmacokinetics With an Increased Dose During Pregnancy. J Acquir Immune Defic Syndr. 2020 04 01; 83(4):373-380. Eke AC, Stek AM, Wang J, Kreitchmann R, Shapiro DE, Smith E, Chakhtoura N, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team. PMID: 31923087; PMCID: PMC7258985.
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    69. Fosamprenavir with Ritonavir Pharmacokinetics during Pregnancy. Antimicrob Agents Chemother. 2020 03 24; 64(4). Eke AC, Wang J, Amin K, Shapiro DE, Stek A, Smith E, Chakhtoura N, Basar M, George K, Knapp KM, João EC, Rungruengthanakit K, Capparelli E, Burchett S, Mirochnick M, Best BM, P1026s Protocol Team. PMID: 32015036; PMCID: PMC7179299.
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    70. Use of Simulation Strategies to Predict Subtherapeutic Meropenem Exposure Caused by Augmented Renal Clearance in Critically Ill Pediatric Patients With Sepsis. J Pediatr Pharmacol Ther. 2020; 25(5):413-422. Avedissian SN, Skochko SM, Le J, Hingtgen S, Harvey H, Capparelli EV, Richardson A, Momper J, Mak RH, Neely M, Bradley JS. PMID: 32641911; PMCID: PMC7337137.
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    71. Development and preclinical pharmacology of a novel dCK inhibitor, DI-87. Biochem Pharmacol. 2020 02; 172:113742. Poddar S, Capparelli EV, Rosser EW, Gipson RM, Wei L, Le T, Jung ME, Radu C, Nikanjam M. PMID: 31812677; PMCID: PMC6981055.
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    72. Use of Modeling and Simulations to Determine Raltegravir Dosing in Neonates: A Model for Safely and Efficiently Determining Appropriate Neonatal Dosing Regimens: IMPAACT P1110. J Acquir Immune Defic Syndr. 2019 12 01; 82(4):392-398. Clarke DF, Mirochnick M, Acosta EP, Capparelli E, Chain A, Teppler H, Smith B, Lommerse J, International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1110 Study Team. PMID: 31658182; PMCID: PMC6820708.
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    73. A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. BMC Pediatr. 2019 11 01; 19(1):399. Birbeck GL, Herman ST, Capparelli EV, Dzinjalamala FK, Abdel Baki SG, Mallewa M, Toto NM, Postels DG, Gardiner JC, Taylor TE, Seydel KB. PMID: 31672143; PMCID: PMC6824014.
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    74. Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patients. Cancer Chemother Pharmacol. 2019 12; 84(6):1339-1348. Kawakatsu S, Nikanjam M, Lin M, Le S, Saunders I, Kuo DJ, Capparelli EV. PMID: 31586225.
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    75. Meropenem pharmacokinetics during relapsing peritonitis due to ESBL-producing Enterobacteriaciae in a liver transplant recipient. Clin Case Rep. 2019 Nov; 7(11):2169-2173. Shoji K, Saito J, Oho Y, Matsumoto S, Aoki S, Fukuda A, Sakamoto S, Kasahara M, Capparelli E, Miyairi I. PMID: 31788272; PMCID: PMC6878041.
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    76. Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir. J Clin Pharmacol. 2020 02; 60(2):240-255. Liu XI, Momper JD, Rakhmanina N, van den Anker JN, Green DJ, Burckart GJ, Best BM, Mirochnick M, Capparelli EV, Dallmann A. PMID: 31489678; PMCID: PMC7316130.
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    77. Population pharmacokinetics of siltuximab: impact of disease state. Cancer Chemother Pharmacol. 2019 11; 84(5):993-1001. Nikanjam M, Yang J, Capparelli EV. PMID: 31482226; PMCID: PMC6800650.
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    78. Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial. Lancet HIV. 2019 10; 6(10):e667-e679. Gaudinski MR, Houser KV, Doria-Rose NA, Chen GL, Rothwell RSS, Berkowitz N, Costner P, Holman LA, Gordon IJ, Hendel CS, Kaltovich F, Conan-Cibotti M, Gomez Lorenzo M, Carter C, Sitar S, Carlton K, Gall J, Laurencot C, Lin BC, Bailer RT, McDermott AB, Ko SY, Pegu A, Kwon YD, Kwong PD, Namboodiri AM, Pandey JP, Schwartz R, Arnold F, Hu Z, Zhang L, Huang Y, Koup RA, Capparelli EV, Graham BS, Mascola JR, Ledgerwood JE, VRC 605 study team. PMID: 31473167.
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    79. Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants. J Antimicrob Chemother. 2019 08 01; 74(8):2128-2138. Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W. PMID: 31049551.
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    80. Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years. J Acquir Immune Defic Syndr. 2019 08 01; 81(4):473-480. Bwakura Dangarembizi M, Samson P, Capparelli EV, Moore CB, Jean-Philippe P, Spector SA, Chakhtoura N, Benns A, Zimmer B, Purdue L, Jackson C, Wallis C, Libous JL, Chadwick EG, IMPAACT P1070 Study Team. PMID: 31241542; PMCID: PMC6597185.
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    81. Long-acting or extended-release antiretroviral products for HIV treatment and prevention in infants, children, adolescents, and pregnant and breastfeeding women: knowledge gaps and research priorities. Lancet HIV. 2019 08; 6(8):e552-e558. Nachman S, Townsend CL, Abrams EJ, Archary M, Capparelli E, Clayden P, Lockman S, Jean-Philippe P, Mayer K, Mirochnick M, McKenzie-White J, Struble K, Watts H, Flexner C. PMID: 31307946; PMCID: PMC7152795.
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    82. Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial. BMJ Open. 2019 07 03; 9(7):e030283. Mahomed S, Garrett N, Capparelli E, Baxter C, Zuma NY, Gengiah T, Archary D, Moore P, Samsunder N, Barouch DH, Mascola J, Ledgerwood J, Morris L, Abdool Karim S. PMID: 31272988; PMCID: PMC6615816.
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    83. Determination of Benznidazole in Human Dried Blood Spots by Liquid Chromatography-Mass Spectrometry to Monitor Adherence to Trypanosoma cruzi Infection Treatment in Infants and Children. Am J Trop Med Hyg. 2019 07; 101(1):116-122. Momper JD, Hanan NJ, Rossi SS, Mirochnick MH, Cafferata ML, Lavenia A, Flores I, Gibbons L, Ciganda A, Sosa Estani S, Capparelli EV, Buekens P. PMID: 31115303; PMCID: PMC6609196.
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    84. Using Mycobacterium tuberculosis Single-Nucleotide Polymorphisms To Predict Fluoroquinolone Treatment Response. Antimicrob Agents Chemother. 2019 07; 63(7). Seifert M, Capparelli E, Catanzaro DG, Rodwell TC. PMID: 31085512; PMCID: PMC6591594.
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    85. Midazolam Limited Sampling Strategy With a Population Pharmacokinetic Approach to Simultaneously Estimate Cytochrome P450 (CYP) 3A Constitutive, Inhibition, and Induction/Activation Conditions in Healthy Adults. J Clin Pharmacol. 2019 11; 59(11):1495-1504. Yang J, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Stoch SA, Bertino JS, Nafziger AN, Ma JD. PMID: 31051051.
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    86. Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling. J Antimicrob Chemother. 2019 05 01; 74(5):1348-1356. Schalkwijk S, Ter Heine R, Colbers A, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Moltó J, Mirochnick M, Karlsson MO, Burger DM. PMID: 30715324; PMCID: PMC6477987.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    87. Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults. Front Pediatr. 2019; 7:16. Hanan NJ, Paul ME, Huo Y, Kapetanovic S, Smith E, Siberry G, Brouwers P, Graham B, Johnston B, Capparelli EV, Best BM. PMID: 30788337; PMCID: PMC6372542.
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    88. Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study. Lancet. 2019 03 02; 393(10174):889-898. Gaudinski MR, Coates EE, Novik L, Widge A, Houser KV, Burch E, Holman LA, Gordon IJ, Chen GL, Carter C, Nason M, Sitar S, Yamshchikov G, Berkowitz N, Andrews C, Vazquez S, Laurencot C, Misasi J, Arnold F, Carlton K, Lawlor H, Gall J, Bailer RT, McDermott A, Capparelli E, Koup RA, Mascola JR, Graham BS, Sullivan NJ, Ledgerwood JE, VRC 608 Study team. PMID: 30686586; PMCID: PMC6436835.
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    89. Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease. Clin Pharmacokinet. 2018 12; 57(12):1593-1601. Vande Casteele N, Oyamada J, Shimizu C, Best BM, Capparelli EV, Tremoulet AH, Burns JC. PMID: 29623653.
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    90. Evaluation of Omeprazole Limited Sampling Strategies to Estimate Constitutive Cytochrome P450 2C19 Activity in Healthy Adults. Ther Drug Monit. 2018 12; 40(6):754-758. Lin S, Nikanjam M, Capparelli EV, Allegrini A, Pavone D, Yim DS, Hammami MM, Bertino JS, Nafziger AN, Park YS, Kang JS, Yin OQ, Ma JD. PMID: 30045358; PMCID: PMC6237623.
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    91. Dosing Oncology Therapeutics in Combination Therapy for Renal Dysfunction: The University of California San Diego Study of Personalized Cancer Therapy to Determine Response and Toxicity (UCSD-PREDICT) Experience. Cureus. 2018 Nov 26; 10(11):e3634. Nikanjam M, Wing J, Capparelli E, Kurzrock R. PMID: 30705793; PMCID: PMC6349570.
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    92. Elvitegravir/cobicistat pharmacokinetics in pregnant and postpartum women with HIV. AIDS. 2018 11 13; 32(17):2507-2516. Momper JD, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Badell ML, Acosta EP, Purswani M, Smith E, Chakhtoura N, Park K, Burchett S, Shapiro DE, Mirochnick M, IMPAACT P1026s Protocol Team. PMID: 30134297; PMCID: PMC6209536.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    93. A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women. Clin Pharmacokinet. 2018 11; 57(11):1421-1433. Schalkwijk S, Ter Heine R, Colbers AC, Huitema ADR, Denti P, Dooley KE, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Mirochnick M, Burger DM. PMID: 29520730; PMCID: PMC6182466.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    94. Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum. J Clin Pharmacol. 2019 03; 59(3):386-393. Eke AC, McCormack SA, Best BM, Stek AM, Wang J, Kreitchmann R, Shapiro D, Smith E, Mofenson LM, Capparelli EV, Mirochnick M, IMPAACT P1026s Protocol Team. PMID: 30358179; PMCID: PMC6368469.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    95. Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus. CPT Pharmacometrics Syst Pharmacol. 2018 11; 7(11):718-727. Ku LC, Hornik CP, Beechinor RJ, Chamberlain JM, Guptill JT, Harper B, Capparelli EV, Martz K, Anand R, Cohen-Wolkowiez M, Gonzalez D, Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee. PMID: 30267478; PMCID: PMC6263663.
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    96. Population Pharmacokinetics of Lopinavir/Ritonavir: Changes Across Formulations and Human Development From Infancy Through Adulthood. J Clin Pharmacol. 2018 12; 58(12):1604-1617. Yang J, Nikanjam M, Best BM, Pinto J, Chadwick EG, Daar ES, Havens PL, Rakhmanina N, Capparelli EV. PMID: 30252146; PMCID: PMC6604805.
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    97. Rilpivirine Plasma and Cervicovaginal Concentrations in Women During Pregnancy and Postpartum. J Acquir Immune Defic Syndr. 2018 07 01; 78(3):308-313. Eke AC, Chakhtoura N, Kashuba A, Best BM, Sykes C, Wang J, Stek AM, Smith E, Calabrese S, Capparelli EV, Mirochnick M, IMPAACT P1026s Protocol Team. PMID: 29528944; PMCID: PMC6002878.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    98. Vincristine-associated Neuropathy With Antifungal Usage: A Kaiser Northern California Experience. J Pediatr Hematol Oncol. 2018 07; 40(5):e273-e277. Nikanjam M, Sun A, Albers M, Mangalindin K, Song E, Vempaty H, Sam D, Capparelli EV. PMID: 29771861; PMCID: PMC6019195.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    99. Midazolam Single Time Point Concentrations to Estimate Exposure and Cytochrome P450 (CYP) 3A Constitutive Activity Utilizing Limited Sampling Strategy With a Population Pharmacokinetic Approach. J Clin Pharmacol. 2018 09; 58(9):1205-1213. Yang J, Patel M, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Aubrey Stoch S, Bertino JS, Nafziger AN, Ma JD. PMID: 29663428.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    100. Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV. AIDS. 2018 03 27; 32(6):729-737. Mulligan N, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Buschur SL, Acosta EP, Smith E, Chakhtoura N, Burchett S, Mirochnick M, IMPAACT P1026s Protocol Team. PMID: 29369162; PMCID: PMC5854536.
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    101. A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines. Pediatr Infect Dis J. 2018 02; 37(2):e29-e35. Pinto JA, Capparelli EV, Warshaw M, Zimmer B, Cressey TR, Spector SA, Qin M, Smith B, Siberry GK, Mirochnick M, IMPAACT P1083 Team. PMID: 29088027; PMCID: PMC5762400.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    102. Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults. PLoS Med. 2018 01; 15(1):e1002493. Gaudinski MR, Coates EE, Houser KV, Chen GL, Yamshchikov G, Saunders JG, Holman LA, Gordon I, Plummer S, Hendel CS, Conan-Cibotti M, Lorenzo MG, Sitar S, Carlton K, Laurencot C, Bailer RT, Narpala S, McDermott AB, Namboodiri AM, Pandey JP, Schwartz RM, Hu Z, Koup RA, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE, VRC 606 Study Team. PMID: 29364886; PMCID: PMC5783347.
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    103. Persistent cytarabine and daunorubicin exposure after administration of novel liposomal formulation CPX-351: population pharmacokinetic assessment. Cancer Chemother Pharmacol. 2018 01; 81(1):171-178. Nikanjam M, Capparelli EV, Lancet JE, Louie A, Schiller G. PMID: 29167924; PMCID: PMC5756117.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    104. External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models. Antimicrob Agents Chemother. 2017 12; 61(12). Hwang MF, Beechinor RJ, Wade KC, Benjamin DK, Smith PB, Hornik CP, Capparelli EV, Duara S, Kennedy KA, Cohen-Wolkowiez M, Gonzalez D. PMID: 28893774; PMCID: PMC5700313.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    105. Prevention and treatment of HIV infection in neonates: evidence base for existing WHO dosing recommendations and implementation considerations. Expert Rev Clin Pharmacol. 2018 Jan; 11(1):83-93. Clarke DF, Penazzato M, Capparelli E, Cressey TR, Siberry G, Sugandhi N, Mirochnick M, WHO Paediatric Antiretroviral Working Group. PMID: 29039686.
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    106. Development of Tolerance to Chronic Intermittent Furosemide Therapy in Pediatric Patients. J Pediatr Pharmacol Ther. 2017 Nov-Dec; 22(6):394-398. Kim GJ, Capparelli E, Romanowski G, Proudfoot JA, Tremoulet AH. PMID: 29290738; PMCID: PMC5736250.
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    107. Pharmacokinetics of single-dose ceftaroline fosamil in children with cystic fibrosis. Pediatr Pulmonol. 2017 Nov; 52(11):1424-1434. Le J, Bradley JS, Hingtgen S, Skochko S, Black N, Jones RN, Lim M, Capparelli EV. PMID: 28910514.
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    108. Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates. J Acquir Immune Defic Syndr. 2017 08 15; 75(5):554-560. Cressey TR, Punyawudho B, Le Coeur S, Jourdain G, Saenjum C, Capparelli EV, Jittayanun K, Phanomcheong S, Luvira A, Borkird T, Puangsombat A, Aarons L, Sukrakanchana PO, Urien S, Lallemant M, PHPT-5 study team. PMID: 28489732; PMCID: PMC5508655.
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    109. Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus. Clin Pharmacokinet. 2017 08; 56(8):941-951. Gonzalez D, Chamberlain JM, Guptill JT, Cohen-Wolkowiez M, Harper B, Zhao J, Capparelli EV, Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. PMID: 27943220; PMCID: PMC5466505.
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    110. Basis and Statistical Design of the Passive HIV-1 Antibody Mediated Prevention (AMP) Test-of-Concept Efficacy Trials. Stat Commun Infect Dis. 2017 Jan; 9(1). Gilbert PB, Juraska M, deCamp AC, Karuna S, Edupuganti S, Mgodi N, Donnell DJ, Bentley C, Sista N, Andrew P, Isaacs A, Huang Y, Zhang L, Capparelli E, Kochar N, Wang J, Eshleman SH, Mayer KH, Magaret CA, Hural J, Kublin JG, Gray G, Montefiori DC, Gomez MM, Burns DN, McElrath J, Ledgerwood J, Graham BS, Mascola JR, Cohen M, Corey L. PMID: 29218117; PMCID: PMC5714515.
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    111. Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial. Ann Clin Transl Neurol. 2017 07; 4(7):491-505. Naviaux RK, Curtis B, Li K, Naviaux JC, Bright AT, Reiner GE, Westerfield M, Goh S, Alaynick WA, Wang L, Capparelli EV, Adams C, Sun J, Jain S, He F, Arellano DA, Mash LE, Chukoskie L, Lincoln A, Townsend J. PMID: 28695149; PMCID: PMC5497533.
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    112. CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection. AIDS. 2017 05 15; 31(8):1129-1136. Bolton Moore C, Capparelli EV, Samson P, Bwakura-Dangarembizi M, Jean-Philippe P, Worrell C, Heckman B, Purdue L, Spector SA, Benns A, Borkowsky W, Loftis A, Hawkins E, Wallis C, Chadwick EG, IMPAACT P1070 team. PMID: 28323755; PMCID: PMC5623109.
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    113. Population Pharmacokinetics of Dexmedetomidine in Infants. J Clin Pharmacol. 2017 09; 57(9):1174-1182. Greenberg RG, Wu H, Laughon M, Capparelli E, Rowe S, Zimmerman KO, Smith PB, Cohen-Wolkowiez M. PMID: 28444697; PMCID: PMC5561462.
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    114. Population pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults. MAbs. 2017 07; 9(5):792-800. Huang Y, Zhang L, Ledgerwood J, Grunenberg N, Bailer R, Isaacs A, Seaton K, Mayer KH, Capparelli E, Corey L, Gilbert PB. PMID: 28368743; PMCID: PMC5524155.
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    115. Utility of Spot Urine Specimens to Assess Tubular Secretion. Am J Kidney Dis. 2017 May; 69(5):709-711. Garimella PS, Li K, Naviaux JC, Shlipak MG, Abdelmalek JA, Castro E, Capparelli EV, Naviaux RK, Ix JH. PMID: 28284759.
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    116. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 01; 61(1). Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. PMID: 27821451; PMCID: PMC5192119.
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    117. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. N Engl J Med. 2016 11 24; 375(21):2037-2050. Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW. PMID: 27959728; PMCID: PMC5292134.
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    118. Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients. J Antimicrob Chemother. 2017 02; 72(2):490-495. Bouazza N, Cressey TR, Foissac F, Bienczak A, Denti P, McIlleron H, Burger D, Penazzato M, Lallemant M, Capparelli EV, Treluyer JM, Urien S. PMID: 27798221.
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    119. Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams. Antimicrob Agents Chemother. 2016 09; 60(9):5539-45. Momper JD, Capparelli EV, Wade KC, Kantak A, Dhanireddy R, Cummings JJ, Nedrelow JH, Hudak ML, Mundakel GT, Natarajan G, Gao J, Laughon M, Smith PB, Benjamin DK. PMID: 27401564; PMCID: PMC4997840.
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    120. Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates. J Pediatr. 2016 Nov; 178:125-129.e1. Hornik CP, Benjamin DK, Smith PB, Pencina MJ, Tremoulet AH, Capparelli EV, Ericson JE, Clark RH, Cohen-Wolkowiez M, Best Pharmaceuticals for Children Act—Pediatric Trials Network. PMID: 27522443; PMCID: PMC5085855.
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    121. Etravirine Pharmacokinetics in HIV-Infected Pregnant Women. Front Pharmacol. 2016; 7:239. Mulligan N, Schalkwijk S, Best BM, Colbers A, Wang J, Capparelli EV, Moltó J, Stek AM, Taylor G, Smith E, Hidalgo Tenorio C, Chakhtoura N, van Kasteren M, Fletcher CV, Mirochnick M, Burger D. PMID: 27540363; PMCID: PMC4972814.
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    122. Association of concurrent acid-suppression therapy with survival outcomes and adverse event incidence in oncology patients receiving erlotinib. Cancer Chemother Pharmacol. 2016 Aug; 78(2):427-32. Lam LH, Capparelli EV, Kurzrock R. PMID: 27372908; PMCID: PMC4967016.
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    123. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016 07; 157(7):1499-1507. Atkinson JH, Slater MA, Capparelli EV, Patel SM, Wolfson T, Gamst A, Abramson IS, Wallace MS, Funk SD, Rutledge TR, Wetherell JL, Matthews SC, Zisook S, Garfin SR. PMID: 26963844; PMCID: PMC5001843.
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    124. Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women. J Acquir Immune Defic Syndr. 2016 07 01; 72(3):289-96. Tran AH, Best BM, Stek A, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, George K, Cressey TR, Chakhtoura N, Smith E, Shapiro DE, Mirochnick M, IMPAACT P1026s Protocol Team. PMID: 26918544; PMCID: PMC4911231.
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    125. Pharmacokinetics, Safety and Tolerability of Single Oral or Intravenous Administration of 200 mg Tedizolid Phosphate in Adolescents. Pediatr Infect Dis J. 2016 06; 35(6):628-33. Bradley JS, Flanagan SD, Arrieta AC, Jacobs R, Capparelli E, Prokocimer P. PMID: 26910588.
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    126. Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms. Antimicrob Agents Chemother. 2016 Apr; 60(4):2150-6. Shoji K, Bradley JS, Reed MD, van den Anker JN, Domonoske C, Capparelli EV. PMID: 26810655; PMCID: PMC4808231.
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    127. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci Transl Med. 2015 12 23; 7(319):319ra206. Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P, Enama ME, Plummer S, Holman L, Hendel CS, Gordon I, Casazza J, Conan-Cibotti M, Migueles SA, Tressler R, Bailer RT, McDermott A, Narpala S, O'Dell S, Wolf G, Lifson JD, Freemire BA, Gorelick RJ, Pandey JP, Mohan S, Chomont N, Fromentin R, Chun TW, Fauci AS, Schwartz RM, Koup RA, Douek DC, Hu Z, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE, VRC 601 Study Team. PMID: 26702094.
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    128. Optimizing drugs to reach treatment targets for children and adolescents living with HIV. J Int AIDS Soc. 2015; 18(Suppl 6):20270. Penazzato M, Lee J, Capparelli E, Essajee S, Ford N, Ojoo A, Pascual F, Sugandhi N, Lallemant M. PMID: 26639117; PMCID: PMC4670841.
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    129. Pharmacokinetics of Once Versus Twice Daily Darunavir in Pregnant HIV-Infected Women. J Acquir Immune Defic Syndr. 2015 Sep 01; 70(1):33-41. Stek A, Best BM, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, Cressey TR, Mofenson LM, Smith E, Shapiro D, Mirochnick M. PMID: 25950206; PMCID: PMC4579345.
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    130. Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants. Clin Infect Dis. 2015 Dec 15; 61(12):1862-70. Uprety P, Chadwick EG, Rainwater-Lovett K, Ziemniak C, Luzuriaga K, Capparelli EV, Yenokyan G, Persaud D. PMID: 26270687; PMCID: PMC4657533.
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    131. Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women. Clin Infect Dis. 2015 Nov 15; 61(10):1582-9. Colbers A, Best B, Schalkwijk S, Wang J, Stek A, Hidalgo Tenorio C, Hawkins D, Taylor G, Kreitchmann R, Burchett S, Haberl A, Kabeya K, van Kasteren M, Smith E, Capparelli E, Burger D, Mirochnick M, PANNA Network and the IMPAACT 1026 Study Team. PMID: 26202768; PMCID: PMC4614410.
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    132. Bayesian Estimation of Vancomycin Pharmacokinetics in Obese Children: Matched Case-Control Study. Clin Ther. 2015 Jun 01; 37(6):1340-51. Le J, Capparelli EV, Wahid U, Wu YS, Romanowski GL, Tran TM, Nguyen A, Bradley JS. PMID: 26031618; PMCID: PMC4475435.
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    133. Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation. Antimicrob Agents Chemother. 2015 Jul; 59(7):3935-43. Watt KM, Gonzalez D, Benjamin DK, Brouwer KL, Wade KC, Capparelli E, Barrett J, Cohen-Wolkowiez M. PMID: 25896706; PMCID: PMC4468733.
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    134. The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda. Pediatr Infect Dis J. 2015 Mar; 34(3):e63-70. Bartelink IH, Savic RM, Dorsey G, Ruel T, Gingrich D, Scherpbier HJ, Capparelli E, Jullien V, Young SL, Achan J, Plenty A, Charlebois E, Kamya M, Havlir D, Aweeka F. PMID: 25742090; PMCID: PMC4351793.
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    135. Adverse Event Detection and Labeling in Pediatric Drug Development: Antiretroviral Drugs. Ther Innov Regul Sci. 2015 Mar; 49(2):302-309. Momper JD, Chang Y, Jackson M, Schuette P, Seo S, Younis I, Abernethy DR, Yao L, Capparelli EV, Burckart GJ. PMID: 30222418.
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    136. Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing. Cancer Chemother Pharmacol. 2015 Mar; 75(3):495-503. Nikanjam M, Stewart CF, Takimoto CH, Synold TW, Beaty O, Fouladi M, Capparelli EV. PMID: 25557868; PMCID: PMC4344382.
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    137. Raltegravir pharmacokinetics during pregnancy. J Acquir Immune Defic Syndr. 2014 Dec 01; 67(4):375-81. Watts DH, Stek A, Best BM, Wang J, Capparelli EV, Cressey TR, Aweeka F, Lizak P, Kreitchmann R, Burchett SK, Shapiro DE, Hawkins E, Smith E, Mirochnick M, IMPAACT 1026s study team. PMID: 25162818; PMCID: PMC4213295.
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    138. Pharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children. J Pediatric Infect Dis Soc. 2015 Dec; 4(4):e109-16. Le J, Ny P, Capparelli E, Lane J, Ngu B, Muus R, Romanowski G, Vo T, Bradley J. PMID: 26582878; PMCID: PMC4681388.
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    139. Variable and suboptimal nevirapine levels in infants given single-dose nevirapine at birth without maternal prophylaxis. AIDS. 2014 Oct 23; 28(16):2491-3. Dross SE, Rossi SS, Beck IA, Micek MA, Blanco AJ, Seidel KD, Montoya P, Capparelli EV, Frenkel LM. PMID: 25265235; PMCID: PMC4332529.
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    140. Lopinavir/ritonavir plus lamivudine and abacavir or zidovudine dose ratios for paediatric fixed-dose combinations. Antivir Ther. 2015; 20(2):225-33. Bouazza N, Foissac F, Fauchet F, Burger D, Kiechel JR, Treluyer JM, Capparelli EV, Lallemant M, Urien S. PMID: 25279808.
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    141. Optimizing pediatric esmolol dosing using computerized practitioner order entry. J Pediatr Pharmacol Ther. 2014 Oct-Dec; 19(4):302-9. Chao T, Perry JC, Romanowski GL, Tremoulet AH, Capparelli EV. PMID: 25762876; PMCID: PMC4341416.
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    142. Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections. Pediatr Infect Dis J. 2014 Oct; 33(10):e270-2. Autmizguine J, Moran C, Gonzalez D, Capparelli EV, Smith PB, Grant GA, Benjamin DK, Cohen-Wolkowiez M, Watt KM. PMID: 24776517; PMCID: PMC4209191.
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    143. Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia. Ther Drug Monit. 2014 Oct; 36(5):584-9. Sampson MR, Frymoyer A, Rattray B, Cotten CM, Smith PB, Capparelli E, Bonifacio SL, Cohen-Wolkowiez M. PMID: 25225917; PMCID: PMC4166612.
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    144. Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy. J Antimicrob Chemother. 2015 Jan; 70(1):217-24. Cressey TR, Urien S, Capparelli EV, Best BM, Buranabanjasatean S, Limtrakul A, Rawangban B, Sabsanong P, Treluyer JM, Jourdain G, Stek A, Lallemant M, Mirochnick M. PMID: 25261418; PMCID: PMC4267507.
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    145. Vancomycin monitoring in children using bayesian estimation. Ther Drug Monit. 2014 Aug; 36(4):510-8. Le J, Ngu B, Bradley JS, Murray W, Nguyen A, Nguyen L, Romanowski GL, Vo T, Capparelli EV. PMID: 24452067; PMCID: PMC4101060.
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    146. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. PLoS Negl Trop Dis. 2014; 8(7):e2973. Andrade RM, Chaparro JD, Capparelli E, Reed SL. PMID: 25079790; PMCID: PMC4117455.
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    147. Pharmacokinetics and pharmacodynamics of antifungals in children: clinical implications. Drugs. 2014 Jun; 74(8):891-909. Autmizguine J, Guptill JT, Cohen-Wolkowiez M, Benjamin DK, Capparelli EV. PMID: 24872147; PMCID: PMC4073603.
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    148. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014 Jun; 58(6):3013-20. Tremoulet A, Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Salgado A, Ian-U Chong S, Melloni C, Gao J, Benjamin DK, Capparelli EV, Cohen-Wolkowiez M, Administrative Core Committee of the Best Pharmaceuticals for Children Act-Pediatric Trials Network. PMID: 24614374; PMCID: PMC4068432.
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    149. Developmental pharmacokinetics of piperacillin and tazobactam using plasma and dried blood spots from infants. Antimicrob Agents Chemother. 2014 May; 58(5):2856-65. Cohen-Wolkowiez M, Watt KM, Zhou C, Bloom BT, Poindexter B, Castro L, Gao J, Capparelli EV, Benjamin DK, Smith PB. PMID: 24614369; PMCID: PMC3993246.
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    150. Population pharmacokinetics of intravenous acyclovir in preterm and term infants. Pediatr Infect Dis J. 2014 Jan; 33(1):42-9. Sampson MR, Bloom BT, Lenfestey RW, Harper B, Kashuba AD, Anand R, Benjamin DK, Capparelli E, Cohen-Wolkowiez M, Smith PB, Best Pharmaceuticals for Children Act–Pediatric Trials Network. PMID: 24346595; PMCID: PMC3904301.
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    151. Population-Based Pharmacokinetic Modeling of Vancomycin in Children with Renal Insufficiency. J Pharmacol Clin Toxicol. 2014; 2(1):1017-1026. Le J, Vaida F, Nguyen E, Adler-Shohet FC, Romanowski G, Kim J, Vo T, Capparelli EV. PMID: 25309945; PMCID: PMC4191860.
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    152. Reduced indinavir exposure during pregnancy. Br J Clin Pharmacol. 2013 Sep; 76(3):475-83. Cressey TR, Best BM, Achalapong J, Stek A, Wang J, Chotivanich N, Yuthavisuthi P, Suriyachai P, Prommas S, Shapiro DE, Watts DH, Smith E, Capparelli E, Kreitchmann R, Mirochnick M, IMPAACT P1026s team. PMID: 23305215; PMCID: PMC3769674.
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    153. Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants. Pediatr Infect Dis J. 2013 Sep; 32(9):956-61. Cohen-Wolkowiez M, Sampson M, Bloom BT, Arrieta A, Wynn JL, Martz K, Harper B, Kearns GL, Capparelli EV, Siegel D, Benjamin DK, Smith PB, Best Pharmaceuticals for Children Act–Pediatric Trials Network. PMID: 23587979; PMCID: PMC3769518.
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    154. Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants. Pediatr Infect Dis J. 2013 Jul; 32(7):748-53. Hornik CP, Herring AH, Benjamin DK, Capparelli EV, Kearns GL, van den Anker J, Cohen-Wolkowiez M, Clark RH, Smith PB, Best Pharmaceuticals for Children Act-Pediatric Trials Network. PMID: 23838776; PMCID: PMC3708263.
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    155. External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings. Br J Clin Pharmacol. 2013 Apr; 75(4):1068-80. Zhao W, Kaguelidou F, Biran V, Zhang D, Allegaert K, Capparelli EV, Holford N, Kimura T, Lo YL, Peris JE, Thomson A, van den Anker JN, Fakhoury M, Jacqz-Aigrain E. PMID: 23148919; PMCID: PMC3612725.
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    156. Improved vancomycin dosing in children using area under the curve exposure. Pediatr Infect Dis J. 2013 Apr; 32(4):e155-63. Le J, Bradley JS, Murray W, Romanowski GL, Tran TT, Nguyen N, Cho S, Natale S, Bui I, Tran TM, Capparelli EV. PMID: 23340565; PMCID: PMC3632448.
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    157. Determination of efavirenz in human dried blood spots by reversed-phase high-performance liquid chromatography with UV detection. Ther Drug Monit. 2013 Apr; 35(2):203-8. Hoffman JT, Rossi SS, Espina-Quinto R, Letendre S, Capparelli EV. PMID: 23503446; PMCID: PMC3848783.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    158. Etravirine in CSF is highly protein bound. J Antimicrob Chemother. 2013 May; 68(5):1161-8. Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S, CHARTER Group. PMID: 23335197; PMCID: PMC3625433.
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    159. Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana. Antivir Ther. 2013; 18(4):585-90. Shapiro RL, Rossi S, Ogwu A, Moss M, Leidner J, Moffat C, Lockman S, Moyo S, Makhema J, Essex M, Capparelli E. PMID: 23183881; PMCID: PMC5502724.
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    160. Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration. J Antimicrob Chemother. 2013 Mar; 68(3):684-9. Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S, CHARTER Group. PMID: 23143899; PMCID: PMC3566670.
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    161. Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. Pediatr Infect Dis J. 2012 Oct; 31(10):1042-7. Watt KM, Benjamin DK, Cheifetz IM, Moorthy G, Wade KC, Smith PB, Brouwer KL, Capparelli EV, Cohen-Wolkowiez M. PMID: 22627870; PMCID: PMC3444624.
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    162. Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections. Clin Infect Dis. 2012 Dec; 55(11):1495-502. Cohen-Wolkowiez M, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Randolph DA, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Rich W, Brozanski BS, van den Anker J, Blumer J, Laughon M, Watt KM, Kearns GL, Capparelli EV, Martz K, Berezny K, Benjamin DK, Smith PB, Meropenem Study Team. PMID: 22955430; PMCID: PMC3491861.
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    163. Nevirapine exposure with WHO pediatric weight band dosing: enhanced therapeutic concentrations predicted based on extensive international pharmacokinetic experience. Antimicrob Agents Chemother. 2012 Oct; 56(10):5374-80. Nikanjam M, Kabamba D, Cressey TR, Burger D, Aweeka FT, Acosta EP, Spector SA, Capparelli EV. PMID: 22869579; PMCID: PMC3457371.
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    164. Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age. AIDS. 2012 Jul 31; 26(12):1483-90. Persaud D, Palumbo PE, Ziemniak C, Hughes MD, Alvero CG, Luzuriaga K, Yogev R, Capparelli EV, Chadwick EG. PMID: 22555165; PMCID: PMC3495308.
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    165. Pharmacokinetic considerations of perinatal antiretroviral therapy. Curr Drug Metab. 2012 Jul; 13(6):744-59. Rakhmanina NY, Dirajlal-Fargo S, Capparelli EV, Mirochnik M. PMID: 22452457.
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    166. High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count. Ther Drug Monit. 2012 Jun; 34(3):237-41. Rakhmanina NY, Neely MN, Capparelli EV. PMID: 22549499; PMCID: PMC3354040.
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    167. A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur during the first week of life. Pediatr Res. 2012 Jul; 72(1):43-9. Sharpe CM, Capparelli EV, Mower A, Farrell MJ, Soldin SJ, Haas RH. PMID: 22495532.
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    168. Pharmacokinetics of nevirapine in HIV and tuberculosis-coinfected children receiving antiretroviral fixed-dose combination tablets while receiving rifampicin-containing tuberculosis treatment and after rifampicin discontinuation. Pediatr Infect Dis J. 2012 Apr; 31(4):389-91. Prasitsuebsai W, Cressey TR, Capparelli E, Vanprapar N, Lapphra K, Chokephaibulkit K. PMID: 22146740.
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    169. Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir. J Acquir Immune Defic Syndr. 2012 Apr 01; 59(4):376-81. Best BM, Letendre SL, Koopmans P, Rossi SS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Capparelli EV, Ellis RJ, Grant I, CHARTER Study Group. PMID: 22217676; PMCID: PMC3299895.
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    170. Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum. J Acquir Immune Defic Syndr. 2012 Mar 01; 59(3):245-52. Cressey TR, Stek A, Capparelli E, Bowonwatanuwong C, Prommas S, Sirivatanapa P, Yuthavisuthi P, Neungton C, Huo Y, Smith E, Best BM, Mirochnick M, IMPAACT P1026s Team. PMID: 22083071; PMCID: PMC3288559.
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    171. Therapeutic amprenavir concentrations in cerebrospinal fluid. Antimicrob Agents Chemother. 2012 Apr; 56(4):1985-9. Croteau D, Letendre S, Best BM, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Way L, Capparelli E, Grant I, CHARTER Group. PMID: 22290964; PMCID: PMC3318381.
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    172. Developmental pharmacokinetic changes of Lamivudine in infants and children. J Clin Pharmacol. 2012 Dec; 52(12):1824-32. Tremoulet AH, Nikanjam M, Cressey TR, Chokephaibulkit K, McKinney R, Mirochnick M, Capparelli EV. PMID: 22180560; PMCID: PMC3369109.
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    173. Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children. J Acquir Immune Defic Syndr. 2011 Dec 01; 58(4):385-91. Best BM, Capparelli EV, Diep H, Rossi SS, Farrell MJ, Williams E, Lee G, van den Anker JN, Rakhmanina N. PMID: 21876444; PMCID: PMC3205189.
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    174. Pharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus. J Pediatr. 2012 Apr; 160(4):667-672.e2. Chamberlain JM, Capparelli EV, Brown KM, Vance CW, Lillis K, Mahajan P, Lichenstein R, Stanley RM, Davis CO, Gordon S, Baren JM, van den Anker JN, Pediatric Emergency Care Applied Research Network (PECARN). PMID: 22050870; PMCID: PMC3274567.
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    175. Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping. Eur J Clin Pharmacol. 2012 Apr; 68(4):407-13. Lawson EB, Wu JC, Baldwin RM, Ingelman-Sundberg M, Rosenborg S, Yim DS, Yin OQ, Capparelli EV, Ma JD. PMID: 22009190.
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    176. Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. Pediatr Infect Dis J. 2011 Oct; 30(10):844-9. Smith PB, Cohen-Wolkowiez M, Castro LM, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Bhatt-Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Brozanski BS, Sanchez P, van den Anker J, Blumer J, Kearns GL, Capparelli EV, Anand R, Benjamin DK, Meropenem Study Team. PMID: 21829139; PMCID: PMC3173561.
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    177. Innovative clinical trial design for pediatric therapeutics. Expert Rev Clin Pharmacol. 2011 Sep; 4(5):643-52. Laughon MM, Benjamin DK, Capparelli EV, Kearns GL, Berezny K, Paul IM, Wade K, Barrett J, Smith PB, Cohen-Wolkowiez M. PMID: 21980319; PMCID: PMC3184526.
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    178. Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria. Malar J. 2011 May 08; 10:114. Morris CA, Onyamboko MA, Capparelli E, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright L, Tshefu AK, Meshnick S, Fleckenstein L. PMID: 21548983; PMCID: PMC3098207.
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    179. Atazanavir pharmacokinetics with and without tenofovir during pregnancy. J Acquir Immune Defic Syndr. 2011 Apr 15; 56(5):412-9. Mirochnick M, Best BM, Stek AM, Capparelli EV, Hu C, Burchett SK, Rossi SS, Hawkins E, Basar M, Smith E, Read JS, IMPAACT 1026s Study Team. PMID: 21283017; PMCID: PMC3125419.
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    180. Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy. AIDS. 2011 Mar 13; 25(5):643-9. Chadwick EG, Yogev R, Alvero CG, Hughes MD, Hazra R, Pinto JA, Robbins BL, Heckman BE, Palumbo PE, Capparelli EV, International Pediatric Adolescent Clinical Trials Group (IMPAACT) P1030 Team. PMID: 21297419; PMCID: PMC3068474.
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    181. Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC. Malar J. 2011 Feb 28; 10:49. Onyamboko MA, Meshnick SR, Fleckenstein L, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright LL, Tshefu AK, Capparelli EV. PMID: 21352601; PMCID: PMC3056842.
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    182. Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):198-202. Barshop NJ, Capparelli EV, Sirlin CB, Schwimmer JB, Lavine JE. PMID: 21240014; PMCID: PMC3059772.
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    183. Bioequivalence of dispersed stavudine: opened versus closed capsule dosing. Antivir Ther. 2011; 16(7):1131-4. Innes S, Norman J, Smith P, Smuts M, Capparelli E, Rosenkranz B, Cotton M. PMID: 22024529; PMCID: PMC5054241.
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    184. Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine in HIV-infected children. Antivir Ther. 2011; 16(8):1287-95. Chokephaibulkit K, Cressey TR, Capparelli E, Sirisanthana V, Muresan P, Hongsiriwon S, Ngampiyaskul C, Limwongse C, Wittawatmongkol O, Aurpibul L, Kabat B, Toye M, Smith ME, Eksaengsri A, McIntosh K, Yogev R, IMPAACT P1069 Team. PMID: 22155910; PMCID: PMC3348490.
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    185. Efavirenz concentrations in CSF exceed IC50 for wild-type HIV. J Antimicrob Chemother. 2011 Feb; 66(2):354-7. Best BM, Koopmans PP, Letendre SL, Capparelli EV, Rossi SS, Clifford DB, Collier AC, Gelman BB, Mbeo G, McCutchan JA, Simpson DM, Haubrich R, Ellis R, Grant I, CHARTER Group. PMID: 21098541; PMCID: PMC3019085.
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    186. A chewable pediatric fixed-dose combination tablet of stavudine, lamivudine, and nevirapine: pharmacokinetics and safety compared with the individual liquid formulations in human immunodeficiency virus-infected children in Thailand. Pediatr Infect Dis J. 2010 Oct; 29(10):940-4. Vanprapar N, Cressey TR, Chokephaibulkit K, Muresan P, Plipat N, Sirisanthana V, Prasitsuebsai W, Hongsiriwan S, Chotpitayasunondh T, Eksaengsri A, Toye M, Smith ME, McIntosh K, Capparelli E, Yogev R, IMPAACT P1056 Team. PMID: 20453709; PMCID: PMC2981099.
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    187. Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1. Antimicrob Agents Chemother. 2010 Dec; 54(12):5156-60. Croteau D, Letendre S, Best BM, Ellis RJ, Breidinger S, Clifford D, Collier A, Gelman B, Marra C, Mbeo G, McCutchan A, Morgello S, Simpson D, Way L, Vaida F, Ueland S, Capparelli E, Grant I, CHARTER Group. PMID: 20876368; PMCID: PMC2981289.
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    188. Lopinavir tablet pharmacokinetics with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2010 Aug; 54(4):381-8. Best BM, Stek AM, Mirochnick M, Hu C, Li H, Burchett SK, Rossi SS, Smith E, Read JS, Capparelli EV, International Maternal Pediatric Adolescent AIDS Clinical Trials Group 1026s Study Team. PMID: 20632458; PMCID: PMC3265163.
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    189. CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2010 Jul; 54(3):285-9. Saitoh A, Capparelli E, Aweeka F, Sarles E, Singh KK, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton T, Spector SA. PMID: 19890215; PMCID: PMC3119357.
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    190. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 04; 362(9):790-9. Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC, Childhood Absence Epilepsy Study Group. PMID: 20200383; PMCID: PMC2924476.
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    191. Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women. J Antimicrob Chemother. 2009 Dec; 64(6):1265-73. Chantarangsu S, Cressey TR, Mahasirimongkol S, Capparelli E, Tawon Y, Ngo-Giang-Huong N, Jourdain G, Lallemant M, Chantratita W. PMID: 19812066; PMCID: PMC2775665.
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    192. Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos. 2009 Aug; 37(8):1779-84. James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM. PMID: 19439490; PMCID: PMC2712440.
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    193. Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: a randomized, placebo-controlled, single-blind, dose-escalation, crossover study. Clin Ther. 2009 Apr; 31(4):806-15. Malloy J, Capparelli E, Gottschalk M, Guan X, Kothare P, Fineman M. PMID: 19446153.
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    194. Is there a therapeutic window with some antidepressants for analgesic response? Curr Pain Headache Rep. 2009 Apr; 13(2):93-9. Atkinson JH, Patel SM, Meyer JM, Slater MA, Zisook S, Capparelli E. PMID: 19272274.
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    195. Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr. 2009 Apr; 21(2):177-81. Cohen-Wolkowiez M, Benjamin DK, Capparelli E. PMID: 19276977; PMCID: PMC3319032.
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    196. Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacy. Pediatr Infect Dis J. 2009 Mar; 28(3):215-9. Chadwick EG, Pinto J, Yogev R, Alvero CG, Hughes MD, Palumbo P, Robbins B, Hazra R, Serchuck L, Heckman BE, Purdue L, Browning R, Luzuriaga K, Rodman J, Capparelli E, International Maternal Pediatric Adolescent Clinical Trials Group (IMPAACT) P1030 Team. PMID: 19209098; PMCID: PMC3176632.
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    197. Low atazanavir concentrations in cerebrospinal fluid. AIDS. 2009 Jan 02; 23(1):83-7. Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli EV, Grant I, CHARTER Group. PMID: 19050389; PMCID: PMC2642983.
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    198. Antiretroviral concentrations in breast-feeding infants of mothers receiving highly active antiretroviral therapy. Antimicrob Agents Chemother. 2009 Mar; 53(3):1170-6. Mirochnick M, Thomas T, Capparelli E, Zeh C, Holland D, Masaba R, Odhiambo P, Fowler MG, Weidle PJ, Thigpen MC. PMID: 19114673; PMCID: PMC2650559.
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    199. Lopinavir exposure with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2008 Dec 15; 49(5):485-91. Mirochnick M, Best BM, Stek AM, Capparelli E, Hu C, Burchett SK, Holland DT, Smith E, Gaddipati S, Read JS, PACTG 1026s Study Team. PMID: 18989231; PMCID: PMC3912695.
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    200. Rapid weight gain in children soon after diagnosis of type 1 diabetes: is there room for concern? Pediatr Diabetes. 2009 Aug; 10(5):310-5. Newfield RS, Cohen D, Capparelli EV, Shragg P. PMID: 19067888.
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    201. Nitazoxanide treatment of Cryptosporidium parvum in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 2008 Nov; 27(11):1041. Capparelli EV, Syed SS. PMID: 18818555; PMCID: PMC3974820.
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    202. Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate. Pediatr Infect Dis J. 2008 Sep; 27(9):794-9. Bradley JS, Sauberan JB, Ambrose PG, Bhavnani SM, Rasmussen MR, Capparelli EV. PMID: 18645546.
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    203. Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2008 Dec; 153(6):833-8. Burns JC, Best BM, Mejias A, Mahony L, Fixler DE, Jafri HS, Melish ME, Jackson MA, Asmar BI, Lang DJ, Connor JD, Capparelli EV, Keen ML, Mamun K, Keenan GF, Ramilo O. PMID: 18672254; PMCID: PMC2856847.
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    204. Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors. Antimicrob Agents Chemother. 2008 Sep; 52(9):3276-83. Robbins BL, Capparelli EV, Chadwick EG, Yogev R, Serchuck L, Worrell C, Smith ME, Alvero C, Fenton T, Heckman B, Pelton SI, Aldrovandi G, Borkowsky W, Rodman J, Havens PL, PACTG 1038 Team. PMID: 18625762; PMCID: PMC2533475.
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    205. Implications of gender and pregnancy for antiretroviral drug dosing. Curr Opin HIV AIDS. 2008 May; 3(3):277-82. Best BM, Capparelli EV. PMID: 19372979; PMCID: PMC2804899.
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    206. Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics. HIV Med. 2008 Apr; 9(4):214-20. Capparelli EV, Aweeka F, Hitti J, Stek A, Hu C, Burchett SK, Best B, Smith E, Read JS, Watts H, Nachman S, Thorpe EM, Spector SA, Jimenez E, Shearer WT, Foca M, Mirochnick M, PACTG 1026S Study Team, PACTG P1022 Study Team. PMID: 18366444; PMCID: PMC2755564.
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    207. UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Am J Hematol. 2008 Mar; 83(3):200-2. Darbari DS, van Schaik RH, Capparelli EV, Rana S, McCarter R, van den Anker J. PMID: 17724700.
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    208. Planned multiple exposures to autologous virus in HIV type 1-infected pediatric populations increases HIV-specific immunity and reduces HIV viremia. AIDS Res Hum Retroviruses. 2008 Mar; 24(3):401-11. Borkowsky W, Yogev R, Muresan P, McFarland E, Frenkel L, Fenton T, Capparelli E, Moye J, Harding P, Ellis N, Heckman B, Kraimer J. PMID: 18327977.
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    209. Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results. AIDS. 2008 Jan 11; 22(2):249-55. Chadwick EG, Capparelli EV, Yogev R, Pinto JA, Robbins B, Rodman JH, Chen J, Palumbo P, Serchuck L, Smith E, Hughes M, P1030 team. PMID: 18097227.
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    210. Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol. 2008 Jan; 65(1):65-70. Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ, CHARTER Group. PMID: 18195140; PMCID: PMC2763187.
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    211. A randomized controlled trial of therapeutic drug monitoring in treatment-naive and -experienced HIV-1-infected patients. J Acquir Immune Defic Syndr. 2007 Dec 01; 46(4):433-42. Best BM, Goicoechea M, Witt MD, Miller L, Daar ES, Diamond C, Tilles JG, Kemper CA, Larsen R, Holland DT, Sun S, Jain S, Wagner G, Capparelli EV, McCutchan JA, Haubrich RH, California Collaborative Treatment Group 578 Study Team. PMID: 17786128.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    212. CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS. 2007 Oct 18; 21(16):2191-9. Saitoh A, Sarles E, Capparelli E, Aweeka F, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton T, Spector SA. PMID: 18090046.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    213. Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants. Antimicrob Agents Chemother. 2007 Dec; 51(12):4297-302. Tremoulet AH, Capparelli EV, Patel P, Acosta EP, Luzuriaga K, Bryson Y, Wara D, Zorrilla C, Holland D, Mirochnick M, Pediatric AIDS Clinical Trials Group. PMID: 17893155; PMCID: PMC2168008.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    214. Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study. Pediatr Crit Care Med. 2007 Sep; 8(5):419-24. Díaz SM, Rodarte A, Foley J, Capparelli EV. PMID: 17693909.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    215. Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents. Antimicrob Agents Chemother. 2007 Oct; 51(10):3516-22. Flynn PM, Rodman J, Lindsey JC, Robbins B, Capparelli E, Knapp KM, Rodriguez JF, McNamara J, Serchuck L, Heckman B, Martinez J, PACTG P1012 Team. PMID: 17664328; PMCID: PMC2043291.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    216. Pharmacologic, pharmacodynamic, and pharmacokinetic considerations with intravenous Ibuprofen lysine. J Pediatr Pharmacol Ther. 2007 Jul; 12(3):158-70. Capparelli EV. PMID: 23055851; PMCID: PMC3462098.
      View in: PubMed   Mentions: 2  
    217. Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. J Clin Psychopharmacol. 2007 Apr; 27(2):135-42. Atkinson JH, Slater MA, Capparelli EV, Wallace MS, Zisook S, Abramson I, Matthews SC, Garfin SR. PMID: 17414235.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    218. Nevirapine concentration in nonstimulated saliva: an alternative to plasma sampling in children with human immunodeficiency virus infection. Ther Drug Monit. 2007 Feb; 29(1):110-7. Rakhmanina NY, Capparelli EV, van den Anker JN, Williams K, Sever JL, Spiegel HM, Soldin SJ. PMID: 17304158.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    219. Population pharmacokinetic model for gatifloxacin in pediatric patients. Antimicrob Agents Chemother. 2007 Apr; 51(4):1246-52. Rubino CM, Capparelli EV, Bradley JS, Blumer JL, Kearns GL, Reed M, Jacobs RF, Cirincione B, Grasela DM. PMID: 17220409; PMCID: PMC1855513.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    220. Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS. J Neuroimmune Pharmacol. 2007 Mar; 2(1):97-104. May S, Letendre S, Haubrich R, McCutchan JA, Heaton R, Capparelli E, Ellis R. PMID: 18040832.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    221. A computer-based system to aid in the interpretation of plasma concentrations of antiretrovirals for therapeutic drug monitoring. Antivir Ther. 2007; 12(1):55-62. Goicoechea M, Vidal A, Capparelli E, Rigby A, Kemper C, Diamond C, Witt MD, Haubrich R, California Collaborative Treatment Group. PMID: 17503748.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    222. Therapeutic ritonavir-boosted atazanavir plasma concentration and concurrent omeprazole use. AIDS. 2006 Oct 24; 20(16):2127-8. Goicoechea M, Best B, Capparelli E, Caperna J, Ballard C, Haubrich R. PMID: 17053363.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    223. Reduced lopinavir exposure during pregnancy. AIDS. 2006 Oct 03; 20(15):1931-9. Stek AM, Mirochnick M, Capparelli E, Best BM, Hu C, Burchett SK, Elgie C, Holland DT, Smith E, Tuomala R, Cotter A, Read JS. PMID: 16988514.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCellsCTClinical Trials
    224. Concurrent use of efavirenz and oxcarbazepine may not affect efavirenz plasma concentrations. Clin Infect Dis. 2006 Jul 01; 43(1):116-7. Goicoechea M, Best B, Capparelli E, Haubrich R, California Collaborative Treatment Group. PMID: 16758435.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    225. Failure of modified directly observed therapy combined with therapeutic drug monitoring to enhance antiretroviral adherence in a patient with major depression. AIDS Patient Care STDS. 2006 Apr; 20(4):233-7. Goicoechea M, Best B, Seefried E, Wagner G, Capparelli E, Haubrich R, California Collaborative Treatment Group (CCTG). PMID: 16623621.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    226. Population pharmacokinetics of troxacitabine, a novel dioxolane nucleoside analogue. Clin Cancer Res. 2006 Apr 01; 12(7 Pt 1):2158-65. Lee CK, Rowinsky EK, Li J, Giles F, Moore MJ, Hidalgo M, Capparelli E, Jolivet J, Baker SD. PMID: 16609029.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    227. Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo W, Hummel P, Johnston CC, Lantos J, Tutag-Lehr V, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. PMID: 16777824.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    228. Impact of pregnancy on abacavir pharmacokinetics. AIDS. 2006 Feb 28; 20(4):553-60. Best BM, Mirochnick M, Capparelli EV, Stek A, Burchett SK, Holland DT, Read JS, Smith E, Hu C, Spector SA, Connor JD, PACTG P1026s Study Team. PMID: 16470119.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    229. Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes. J Clin Pharmacol. 2005 Oct; 45(10):1137-44. Christensen ML, Meibohm B, Capparelli EV, Velasquez-Mieyer P, Burghen GA, Tamborlane WV. PMID: 16172178.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    230. Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants. Antimicrob Agents Chemother. 2005 Oct; 49(10):4121-7. Capparelli EV, Bloom BT, Kueser TJ, Oelberg DG, Bifano EM, White RD, Schelonka RL, Pearlman SA, Patti J, Hetherington SV. PMID: 16189088; PMCID: PMC1251526.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    231. Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination of stavudine, lamivudine and nevirapine. AIDS. 2005 Sep 23; 19(14):1495-9. Chokephaibulkit K, Plipat N, Cressey TR, Frederix K, Phongsamart W, Capparelli E, Kolladarungkri T, Vanprapar N. PMID: 16135903.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    232. Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment. J Infect Dis. 2005 Sep 01; 192(5):720-7. Shapiro RL, Holland DT, Capparelli E, Lockman S, Thior I, Wester C, Stevens L, Peter T, Essex M, Connor JD, Mirochnick M. PMID: 16088821.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    233. Instability of lopinavir/ritonavir capsules at ambient temperatures in sub-Saharan Africa: relevance to WHO antiretroviral guidelines. AIDS. 2005 Jul 22; 19(11):1233-4. Pau AK, Moodley NK, Holland DT, Fomundam H, Matchaba GU, Capparelli EV. PMID: 15990580.
      View in: PubMed   Mentions: 2     Fields:    
    234. Population pharmacokinetics of cefepime in the neonate. Antimicrob Agents Chemother. 2005 Jul; 49(7):2760-6. Capparelli E, Hochwald C, Rasmussen M, Parham A, Bradley J, Moya F. PMID: 15980347; PMCID: PMC1168671.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    235. Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response. J Infect Dis. 2005 Jul 15; 192(2):296-302. Kovacs A, Montepiedra G, Carey V, Pahwa S, Weinberg A, Frenkel L, Capparelli E, Mofenson L, Smith E, McIntosh K, Burchett SK, Pediatric AIDS Clinical Trials Group 366 Study Team. PMID: 15962224.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    236. Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV. AIDS. 2005 Jun 10; 19(9):949-52. Capparelli EV, Holland D, Okamoto C, Gragg B, Durelle J, Marquie-Beck J, van den Brande G, Ellis R, Letendre S, HNRC Group. PMID: 15905676.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    237. Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life. Pediatr Infect Dis J. 2005 Jun; 24(6):503-9. Kovacs A, Cowles MK, Britto P, Capparelli E, Fowler MG, Moye J, McIntosh K, Rathore MH, Pitt J, Husson RN. PMID: 15933559.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    238. Safety and pharmacokinetics of nelfinavir coadministered with zidovudine and lamivudine in infants during the first 6 weeks of life. J Acquir Immune Defic Syndr. 2005 Jun 01; 39(2):189-94. Mirochnick M, Stek A, Acevedo M, Keller M, Holland D, Capparelli E, Connor J, Huang S, Hughes M, Watts H, Mofenson L, Bryson Y. PMID: 15905735.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    239. Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid. Antimicrob Agents Chemother. 2005 Jun; 49(6):2504-6. Capparelli EV, Letendre SL, Ellis RJ, Patel P, Holland D, McCutchan JA. PMID: 15917556; PMCID: PMC1140502.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCellsCTClinical Trials
    240. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005 Jun; 27(6):814-43. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo WA, Hummel P, Lantos J, Johnston CC, Lehr VT, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. PMID: 16117988.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    241. Pharmacokinetics of gatifloxacin in infants and children. Antimicrob Agents Chemother. 2005 Mar; 49(3):1106-12. Capparelli EV, Reed MD, Bradley JS, Kearns GL, Jacobs RF, Damle BD, Blumer JL, Grasela DM. PMID: 15728910; PMCID: PMC549226.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    242. Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1. J Acquir Immune Defic Syndr. 2005 Mar 01; 38(3):283-8. Cressey TR, Jourdain G, Lallemant MJ, Kunkeaw S, Jackson JB, Musoke P, Capparelli E, Mirochnick M. PMID: 15735445.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    243. Pharmacotherapy of perinatal HIV. Semin Fetal Neonatal Med. 2005 Apr; 10(2):161-75. Capparelli E, Rakhmanina N, Mirochnick M. PMID: 15701581.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    244. The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patients. Antivir Ther. 2004 Oct; 9(5):753-61. Yasuda JM, Miller C, Currier JS, Forthal DN, Kemper CA, Beall GN, Tilles JG, Capparelli EV, McCutchan JA, Haubrich RH, California Collaborative Treatment Group. PMID: 15535413.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    245. Pharmacokinetics of antiretrovirals in pregnant women. Clin Pharmacokinet. 2004; 43(15):1071-87. Mirochnick M, Capparelli E. PMID: 15568888.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    246. Model appropriateness and population pharmacokinetic modeling. J Clin Pharmacol. 2003 Jun; 43(6):610-23. Ette EI, Williams PJ, Kim YH, Lane JR, Liu MJ, Capparelli EV. PMID: 12817524.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    247. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J. 2003 Apr; 22(4):335-41. Abzug MJ, Cloud G, Bradley J, Sánchez PJ, Romero J, Powell D, Lepow M, Mani C, Capparelli EV, Blount S, Lakeman F, Whitley RJ, Kimberlin DW, National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. PMID: 12690273.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCTClinical Trials
    248. Pharmacokinetic and tolerability assessment of a pediatric oral formulation of pentoxifylline in kawasaki disease. Curr Ther Res Clin Exp. 2003 Feb; 64(2):96-115. Best BM, Burns JC, DeVincenzo J, Phelps SJ, Blumer JL, Wilson JT, Capparelli EV, Connor JD, Pediatric Pharmacology Research Unit Network. PMID: 24944359; PMCID: PMC4053025.
      View in: PubMed   Mentions: 2     Fields:    
    249. Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children. J Clin Pharmacol. 2003 Feb; 43(2):133-40. Capparelli EV, Englund JA, Connor JD, Spector SA, McKinney RE, Palumbo P, Baker CJ. PMID: 12616665.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    250. Pharmacokinetics and tolerance of zidovudine in preterm infants. J Pediatr. 2003 Jan; 142(1):47-52. Capparelli EV, Mirochnick M, Dankner WM, Blanchard S, Mofenson L, McSherry GD, Gay H, Ciupak G, Smith B, Connor JD, Pediatric AIDS Clinical Trials Group 331 Investigators. PMID: 12520254.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
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