Edmund Capparelli

Title(s)Recall Faculty, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH P50HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH U54HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Academic Training in Therapeutic Advancement for Child Health (ATTACH)
    NIH T32HD087978May 1, 2016 - Apr 30, 2026
    Role: Principal Investigator
    Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy
    NIH U54HD071600Sep 26, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Pediatric Pharmacology Research Unit Network
    NIH U10HD031318Jan 1, 1994 - Dec 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients. Microbiol Spectr. 2021 Oct 06; e0046021. Shoji K, Saito J, Nakagawa H, Funaki T, Fukuda A, Sakamoto S, Kasahara M, Momper JD, Capparelli EV, Miyairi I. PMID: 34612690.
      View in: PubMed   Mentions:    Fields:    
    2. Optimizing Dolutegravir Initiation in Neonates using Population Pharmacokinetic Modeling and Simulation. J Acquir Immune Defic Syndr. 2021 Oct 06. Piscitelli J, Nikanjam M, Best BM, Acosta E, Mirochnick M, Clarke DF, Capparelli EV, Momper JD. PMID: 34629412.
      View in: PubMed   Mentions:    Fields:    
    3. Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests. Pharmacogenomics J. 2021 Sep 03. Zhu GD, Whitley P, LaRue L, Adkins B, Dawson E, Huskey A, Capparelli EV, Del Tredici AL. PMID: 34480108.
      View in: PubMed   Mentions:    Fields:    
    4. Interactions between etonogestrel-releasing contraceptive implant and 3 antiretroviral regimens. Contraception. 2021 Aug 15. Kreitchmann R, Stek A, Best BM, Capparelli E, Wang J, Shapiro D, Chakhtoura N, Mirochnick M, Eke AC, IMPAACT P1026s protocol team . PMID: 34407424.
      View in: PubMed   Mentions:    Fields:    
    5. A Monoclonal Antibody for Malaria Prevention. N Engl J Med. 2021 08 26; 385(9):803-814. Gaudinski MR, Berkowitz NM, Idris AH, Coates EE, Holman LA, Mendoza F, Gordon IJ, Plummer SH, Trofymenko O, Hu Z, Campos Chagas A, O'Connell S, Basappa M, Douek N, Narpala SR, Barry CR, Widge AT, Hicks R, Awan SF, Wu RL, Hickman S, Wycuff D, Stein JA, Case C, Evans BP, Carlton K, Gall JG, Vazquez S, Flach B, Chen GL, Francica JR, Flynn BJ, Kisalu NK, Capparelli EV, McDermott A, Mascola JR, Ledgerwood JE, Seder RA, VRC 612 Study Team . PMID: 34379916.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCTClinical Trials
    6. Lopinavir and tenofovir interaction observed in non-pregnant adults altered during pregnancy. J Clin Pharm Ther. 2021 Oct; 46(5):1459-1464. Mulligan N, Salama E, Momper JD, Capparelli EV, Stek A, Chakhtoura N, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team . PMID: 34254323.
      View in: PubMed   Mentions:    Fields:    
    7. Pharmacokinetics of darunavir and cobicistat in pregnant and postpartum women with HIV. AIDS. 2021 07 01; 35(8):1191-1199. Momper JD, Wang J, Stek A, Shapiro DE, Scott GB, Paul ME, Febo IL, Burchett S, Smith E, Chakhtoura N, Denson K, Rungruengthanakit K, George K, Yang DZ, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team . PMID: 34076612.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    8. Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction. Clin Pharmacokinet. 2021 May 27. Tang BH, Guan Z, Allegaert K, Wu YE, Manolis E, Leroux S, Yao BF, Shi HY, Li X, Huang X, Wang WQ, Shen AD, Wang XL, Wang TY, Kou C, Xu HY, Zhou Y, Zheng Y, Hao GX, Xu BP, Thomson AH, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Burggraaf J, Jacqz-Aigrain E, van den Anker J, Zhao W. PMID: 34041714.
      View in: PubMed   Mentions:    Fields:    
    9. Safety, Tolerability, and Pharmacokinetics of a Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01LS in HIV-1-Exposed Newborn Infants. J Infect Dis. 2021 May 02. McFarland EJ, Cunningham CK, Muresan P, Capparelli EV, Perlowski C, Morgan P, Smith B, Hazra R, Purdue L, Harding PA, Theron G, Mujuru H, Agwu A, Purswani M, Rathore MH, Flach B, Taylor A, Lin BC, McDermott AB, Mascola JR, Graham BS, IMPAACT P1112 team . PMID: 34009371.
      View in: PubMed   Mentions: 1     Fields:    
    10. S-warfarin limited sampling strategy with a population pharmacokinetic approach to estimate exposure and cytochrome P450 (CYP) 2C9 activity in healthy adults. Eur J Clin Pharmacol. 2021 Sep; 77(9):1349-1356. Tran L, Nikanjam M, Capparelli EV, Bertino JS, Nafziger AN, Kashuba ADM, Turpault S, Ma JD. PMID: 33754183.
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    11. Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies. Pharmacotherapy. 2021 04; 41(4):405-420. Silmore LH, Willmer AR, Capparelli EV, Rosania GR. PMID: 33583102.
      View in: PubMed   Mentions: 2     Fields:    
    12. Pharmacokinetics of tenofovir alafenamide with and without cobicistat in pregnant and postpartum women living with HIV. AIDS. 2021 03 01; 35(3):407-417. Brooks KM, Momper JD, Pinilla M, Stek AM, Barr E, Weinberg A, Deville JG, Febo IL, Cielo M, George K, Denson K, Rungruengthanakit K, Shapiro DE, Smith E, Chakhtoura N, Rooney JF, Haubrich R, Espina R, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team . PMID: 33252495.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Population Pharmacokinetics of Tenofovir in Pregnant and Postpartum Women Using Tenofovir Disoproxil Fumarate. Antimicrob Agents Chemother. 2021 02 17; 65(3). Eke AC, Shoji K, Best BM, Momper JD, Stek AM, Cressey TR, Mirochnick M, Capparelli EV. PMID: 33318014.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life. Clin Infect Dis. 2021 02 01; 72(3):388-393. Maswabi K, Ajibola G, Bennett K, Capparelli EV, Jean-Philippe P, Moyo S, Mohammed T, Batlang O, Sakoi M, Lockman S, Makhema J, Lichterfeld M, Kuritzkes DR, Hughes MD, Shapiro RL. PMID: 31927562.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol for the first-in-human CAPRISA 012B phase I clinical trial. BMJ Open. 2020 11 26; 10(11):e042247. Mahomed S, Garrett N, Karim QA, Zuma NY, Capparelli E, Baxter C, Gengiah T, Archary D, Samsunder N, Rose ND, Moore P, Williamson C, Barouch DH, Fast PE, Pozzetto B, Hankins C, Carlton K, Ledgerwood J, Morris L, Mascola J, Abdool Karim S. PMID: 33243815.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    16. Pharmacokinetics and safety of early nevirapine-based antiretroviral therapy for neonates at high risk for perinatal HIV infection: a phase 1/2 proof of concept study. Lancet HIV. 2021 03; 8(3):e149-e157. Ruel TD, Capparelli EV, Tierney C, Nelson BS, Coletti A, Bryson Y, Cotton MF, Spector SA, Mirochnick M, LeBlanc R, Reding C, Zimmer B, Persaud D, Bwakura-Dangarembizi M, Naidoo KL, Hazra R, Jean-Philippe P, Chadwick EG. PMID: 33242457.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    17. Optimizing Pharmacology Studies in Pregnant and Lactating Women Using Lessons From HIV: A Consensus Statement. Clin Pharmacol Ther. 2021 07; 110(1):36-48. Eke AC, Olagunju A, Momper J, Penazzato M, Abrams EJ, Best BM, Capparelli EV, Bekker A, Belew Y, Kiser JJ, Struble K, Taylor G, Waitt C, Mirochnick M, Cressey TR, Colbers A, participants of the WHO-IMPAACT workshop on “Approaches to Optimize and Accelerate Pharmacokinetic S . PMID: 32930408.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach. Clin Pharmacol Ther. 2021 01; 109(1):184-192. Li J, Nikanjam M, Cunningham CK, McFarland EJ, Coates EE, Houser KV, Lin BC, McDermott AB, Flach B, Gama L, Koup RA, Graham BS, Mascola JR, Ledgerwood JE, Capparelli EV. PMID: 32866318.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsCTClinical Trials
    19. Intraperitoneal vancomycin for peritoneal dialysis-associated peritonitis in children: Evaluation of loading dose guidelines. Perit Dial Int. 2021 03; 41(2):202-208. Hennessy K, Capparelli EV, Romanowski G, Alejandro L, Murray W, Benador N. PMID: 32862775.
      View in: PubMed   Mentions:    Fields:    
    20. Short-course Benznidazole treatment to reduce Trypanosoma cruzi parasitic load in women of reproductive age (BETTY): a non-inferiority randomized controlled trial study protocol. Reprod Health. 2020 Aug 24; 17(1):128. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Cafferata ML, Toscani MA, Althabe F, Belizán JM, Bergel E, Berrueta M, Capparelli EV, Ciganda Á, Danesi E, Dumonteil E, Gibbons L, Gulayin PE, Herrera C, Momper JD, Rossi S, Shaffer JG, Schijman AG, Sosa-Estani S, Stella CB, Klein K, Buekens P. PMID: 32831069; PMCID: PMC7446054.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCTClinical Trials
    21. Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women Infected with Schistosoma japonicum. Antimicrob Agents Chemother. 2020 08 20; 64(9). Bustinduy AL, Kolamunnage-Dona R, Mirochnick MH, Capparelli EV, Tallo V, Acosta LP, Olveda RM, Friedman JF, Hope WW. PMID: 32631820.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    22. Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing Human Immunodeficiency Virus (HIV)-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants. J Infect Dis. 2020 07 23; 222(4):628-636. Cunningham CK, McFarland EJ, Morrison RL, Capparelli EV, Safrit JT, Mofenson LM, Mathieson B, Valentine ME, Perlowski C, Smith B, Hazra R, Purdue L, Muresan P, Harding PA, Mbengeranwa T, Robinson LG, Wiznia A, Theron G, Lin B, Bailer RT, Mascola JR, Graham BS, IMPAACT P1112 team . PMID: 31681963.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsCTClinical Trials
    23. A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain. Pain. 2020 06; 161(6):1341-1349. Gould HM, Atkinson JH, Chircop-Rollick T, D'Andrea J, Garfin S, Patel SM, Funk SD, Capparelli EV, Penzien DB, Wallace M, Weickgenanta AL, Slater M, Rutledge T. PMID: 32068667.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Meropenem pharmacokinetics during extracorporeal membrane oxygenation and continuous haemodialysis: a case report. J Glob Antimicrob Resist. 2020 09; 22:651-655. Saito J, Shoji K, Oho Y, Aoki S, Matsumoto S, Yoshida M, Nakamura H, Kaneko Y, Hayashi T, Yamatani A, Capparelli E, Miyairi I. PMID: 32417590.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment. J Pediatric Infect Dis Soc. 2020 Apr 30; 9(2):261-264. Higa N, Pelz A, Birch D, Beck IA, Sils T, Samson P, Bwakura-Dangarembizi M, Bolton-Moore C, Capparelli E, Chadwick E, Frenkel LM. PMID: 31194860.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Darunavir Pharmacokinetics With an Increased Dose During Pregnancy. J Acquir Immune Defic Syndr. 2020 04 01; 83(4):373-380. Eke AC, Stek AM, Wang J, Kreitchmann R, Shapiro DE, Smith E, Chakhtoura N, Capparelli EV, Mirochnick M, Best BM, IMPAACT P1026s Protocol Team . PMID: 31923087.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. Fosamprenavir with Ritonavir Pharmacokinetics during Pregnancy. Antimicrob Agents Chemother. 2020 03 24; 64(4). Eke AC, Wang J, Amin K, Shapiro DE, Stek A, Smith E, Chakhtoura N, Basar M, George K, Knapp KM, João EC, Rungruengthanakit K, Capparelli E, Burchett S, Mirochnick M, Best BM, P1026s Protocol Team . PMID: 32015036.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    28. Use of Simulation Strategies to Predict Subtherapeutic Meropenem Exposure Caused by Augmented Renal Clearance in Critically Ill Pediatric Patients With Sepsis. J Pediatr Pharmacol Ther. 2020; 25(5):413-422. Avedissian SN, Skochko SM, Le J, Hingtgen S, Harvey H, Capparelli EV, Richardson A, Momper J, Mak RH, Neely M, Bradley JS. PMID: 32641911.
      View in: PubMed   Mentions:
    29. Development and preclinical pharmacology of a novel dCK inhibitor, DI-87. Biochem Pharmacol. 2020 02; 172:113742. Poddar S, Capparelli EV, Rosser EW, Gipson RM, Wei L, Le T, Jung ME, Radu C, Nikanjam M. PMID: 31812677.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. Use of Modeling and Simulations to Determine Raltegravir Dosing in Neonates: A Model for Safely and Efficiently Determining Appropriate Neonatal Dosing Regimens: IMPAACT P1110. J Acquir Immune Defic Syndr. 2019 12 01; 82(4):392-398. Clarke DF, Mirochnick M, Acosta EP, Capparelli E, Chain A, Teppler H, Smith B, Lommerse J, International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1110 Study Team . PMID: 31658182.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. BMC Pediatr. 2019 11 01; 19(1):399. Birbeck GL, Herman ST, Capparelli EV, Dzinjalamala FK, Abdel Baki SG, Mallewa M, Toto NM, Postels DG, Gardiner JC, Taylor TE, Seydel KB. PMID: 31672143.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patients. Cancer Chemother Pharmacol. 2019 12; 84(6):1339-1348. Kawakatsu S, Nikanjam M, Lin M, Le S, Saunders I, Kuo DJ, Capparelli EV. PMID: 31586225.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Meropenem pharmacokinetics during relapsing peritonitis due to ESBL-producing Enterobacteriaciae in a liver transplant recipient. Clin Case Rep. 2019 Nov; 7(11):2169-2173. Shoji K, Saito J, Oho Y, Matsumoto S, Aoki S, Fukuda A, Sakamoto S, Kasahara M, Capparelli E, Miyairi I. PMID: 31788272.
      View in: PubMed   Mentions:
    34. Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir. J Clin Pharmacol. 2020 02; 60(2):240-255. Liu XI, Momper JD, Rakhmanina N, van den Anker JN, Green DJ, Burckart GJ, Best BM, Mirochnick M, Capparelli EV, Dallmann A. PMID: 31489678.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. Population pharmacokinetics of siltuximab: impact of disease state. Cancer Chemother Pharmacol. 2019 11; 84(5):993-1001. Nikanjam M, Yang J, Capparelli EV. PMID: 31482226.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial. Lancet HIV. 2019 10; 6(10):e667-e679. Gaudinski MR, Houser KV, Doria-Rose NA, Chen GL, Rothwell RSS, Berkowitz N, Costner P, Holman LA, Gordon IJ, Hendel CS, Kaltovich F, Conan-Cibotti M, Gomez Lorenzo M, Carter C, Sitar S, Carlton K, Gall J, Laurencot C, Lin BC, Bailer RT, McDermott AB, Ko SY, Pegu A, Kwon YD, Kwong PD, Namboodiri AM, Pandey JP, Schwartz R, Arnold F, Hu Z, Zhang L, Huang Y, Koup RA, Capparelli EV, Graham BS, Mascola JR, Ledgerwood JE, VRC 605 study team . PMID: 31473167.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    37. Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants. J Antimicrob Chemother. 2019 08 01; 74(8):2128-2138. Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W. PMID: 31049551.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    38. Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years. . 2019 08 01; 81(4):473-480. Bwakura Dangarembizi M, Samson P, Capparelli EV, Moore CB, Jean-Philippe P, Spector SA, Chakhtoura N, Benns A, Zimmer B, Purdue L, Jackson C, Wallis C, Libous JL, Chadwick EG, IMPAACT P1070 Study Team . PMID: 31241542.
      View in: PubMed   Mentions:
    39. Long-acting or extended-release antiretroviral products for HIV treatment and prevention in infants, children, adolescents, and pregnant and breastfeeding women: knowledge gaps and research priorities. Lancet HIV. 2019 08; 6(8):e552-e558. Nachman S, Townsend CL, Abrams EJ, Archary M, Capparelli E, Clayden P, Lockman S, Jean-Philippe P, Mayer K, Mirochnick M, McKenzie-White J, Struble K, Watts H, Flexner C. PMID: 31307946.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial. BMJ Open. 2019 07 03; 9(7):e030283. Mahomed S, Garrett N, Capparelli E, Baxter C, Zuma NY, Gengiah T, Archary D, Moore P, Samsunder N, Barouch DH, Mascola J, Ledgerwood J, Morris L, Abdool Karim S. PMID: 31272988.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    41. Determination of Benznidazole in Human Dried Blood Spots by Liquid Chromatography-Mass Spectrometry to Monitor Adherence to Trypanosoma cruzi Infection Treatment in Infants and Children. Am J Trop Med Hyg. 2019 07; 101(1):116-122. Momper JD, Hanan NJ, Rossi SS, Mirochnick MH, Cafferata ML, Lavenia A, Flores I, Gibbons L, Ciganda A, Sosa Estani S, Capparelli EV, Buekens P. PMID: 31115303.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Using Mycobacterium tuberculosis Single-Nucleotide Polymorphisms To Predict Fluoroquinolone Treatment Response. Antimicrob Agents Chemother. 2019 07; 63(7). Seifert M, Capparelli E, Catanzaro DG, Rodwell TC. PMID: 31085512.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    43. Midazolam Limited Sampling Strategy With a Population Pharmacokinetic Approach to Simultaneously Estimate Cytochrome P450 (CYP) 3A Constitutive, Inhibition, and Induction/Activation Conditions in Healthy Adults. J Clin Pharmacol. 2019 11; 59(11):1495-1504. Yang J, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Stoch SA, Bertino JS, Nafziger AN, Ma JD. PMID: 31051051.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling. J Antimicrob Chemother. 2019 05 01; 74(5):1348-1356. Schalkwijk S, Ter Heine R, Colbers A, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Moltó J, Mirochnick M, Karlsson MO, Burger DM. PMID: 30715324.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults. Front Pediatr. 2019; 7:16. Hanan NJ, Paul ME, Huo Y, Kapetanovic S, Smith E, Siberry G, Brouwers P, Graham B, Johnston B, Capparelli EV, Best BM. PMID: 30788337.
      View in: PubMed   Mentions:
    46. Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study. Lancet. 2019 03 02; 393(10174):889-898. Gaudinski MR, Coates EE, Novik L, Widge A, Houser KV, Burch E, Holman LA, Gordon IJ, Chen GL, Carter C, Nason M, Sitar S, Yamshchikov G, Berkowitz N, Andrews C, Vazquez S, Laurencot C, Misasi J, Arnold F, Carlton K, Lawlor H, Gall J, Bailer RT, McDermott A, Capparelli E, Koup RA, Mascola JR, Graham BS, Sullivan NJ, Ledgerwood JE, VRC 608 Study team . PMID: 30686586.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    47. Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease. Clin Pharmacokinet. 2018 12; 57(12):1593-1601. Vande Casteele N, Oyamada J, Shimizu C, Best BM, Capparelli EV, Tremoulet AH, Burns JC. PMID: 29623653.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    48. Evaluation of Omeprazole Limited Sampling Strategies to Estimate Constitutive Cytochrome P450 2C19 Activity in Healthy Adults. Ther Drug Monit. 2018 12; 40(6):754-758. Lin S, Nikanjam M, Capparelli EV, Allegrini A, Pavone D, Yim DS, Hammami MM, Bertino JS, Nafziger AN, Park YS, Kang JS, Yin OQ, Ma JD. PMID: 30045358.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. Dosing Oncology Therapeutics in Combination Therapy for Renal Dysfunction: The University of California San Diego Study of Personalized Cancer Therapy to Determine Response and Toxicity (UCSD-PREDICT) Experience. Cureus. 2018 Nov 26; 10(11):e3634. Nikanjam M, Wing J, Capparelli E, Kurzrock R. PMID: 30705793.
      View in: PubMed   Mentions:
    50. Elvitegravir/cobicistat pharmacokinetics in pregnant and postpartum women with HIV. AIDS. 2018 11 13; 32(17):2507-2516. Momper JD, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Badell ML, Acosta EP, Purswani M, Smith E, Chakhtoura N, Park K, Burchett S, Shapiro DE, Mirochnick M, IMPAACT P1026s Protocol Team . PMID: 30134297.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    51. A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women. Clin Pharmacokinet. 2018 11; 57(11):1421-1433. Schalkwijk S, Ter Heine R, Colbers AC, Huitema ADR, Denti P, Dooley KE, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Mirochnick M, Burger DM. PMID: 29520730.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    52. Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum. J Clin Pharmacol. 2019 03; 59(3):386-393. Eke AC, McCormack SA, Best BM, Stek AM, Wang J, Kreitchmann R, Shapiro D, Smith E, Mofenson LM, Capparelli EV, Mirochnick M, IMPAACT P1026s Protocol Team . PMID: 30358179.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    53. Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus. CPT Pharmacometrics Syst Pharmacol. 2018 11; 7(11):718-727. Ku LC, Hornik CP, Beechinor RJ, Chamberlain JM, Guptill JT, Harper B, Capparelli EV, Martz K, Anand R, Cohen-Wolkowiez M, Gonzalez D, Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee . PMID: 30267478.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    54. Population Pharmacokinetics of Lopinavir/Ritonavir: Changes Across Formulations and Human Development From Infancy Through Adulthood. J Clin Pharmacol. 2018 12; 58(12):1604-1617. Yang J, Nikanjam M, Best BM, Pinto J, Chadwick EG, Daar ES, Havens PL, Rakhmanina N, Capparelli EV. PMID: 30252146.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    55. Vincristine-associated Neuropathy With Antifungal Usage: A Kaiser Northern California Experience. J Pediatr Hematol Oncol. 2018 07; 40(5):e273-e277. Nikanjam M, Sun A, Albers M, Mangalindin K, Song E, Vempaty H, Sam D, Capparelli EV. PMID: 29771861.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    56. Rilpivirine Plasma and Cervicovaginal Concentrations in Women During Pregnancy and Postpartum. . 2018 07 01; 78(3):308-313. Eke AC, Chakhtoura N, Kashuba A, Best BM, Sykes C, Wang J, Stek AM, Smith E, Calabrese S, Capparelli EV, Mirochnick M, IMPAACT P1026s Protocol Team . PMID: 29528944.
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    57. Midazolam Single Time Point Concentrations to Estimate Exposure and Cytochrome P450 (CYP) 3A Constitutive Activity Utilizing Limited Sampling Strategy With a Population Pharmacokinetic Approach. J Clin Pharmacol. 2018 09; 58(9):1205-1213. Yang J, Patel M, Nikanjam M, Capparelli EV, Tsunoda SM, Greenberg HE, Penzak SR, Aubrey Stoch S, Bertino JS, Nafziger AN, Ma JD. PMID: 29663428.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV. AIDS. 2018 03 27; 32(6):729-737. Mulligan N, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Buschur SL, Acosta EP, Smith E, Chakhtoura N, Burchett S, Mirochnick M, IMPAACT P1026s Protocol Team . PMID: 29369162.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCellsCTClinical Trials
    59. A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines. Pediatr Infect Dis J. 2018 02; 37(2):e29-e35. Pinto JA, Capparelli EV, Warshaw M, Zimmer B, Cressey TR, Spector SA, Qin M, Smith B, Siberry GK, Mirochnick M, IMPAACT P1083 Team . PMID: 29088027.
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    60. Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults. PLoS Med. 2018 01; 15(1):e1002493. Gaudinski MR, Coates EE, Houser KV, Chen GL, Yamshchikov G, Saunders JG, Holman LA, Gordon I, Plummer S, Hendel CS, Conan-Cibotti M, Lorenzo MG, Sitar S, Carlton K, Laurencot C, Bailer RT, Narpala S, McDermott AB, Namboodiri AM, Pandey JP, Schwartz RM, Hu Z, Koup RA, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE, VRC 606 Study Team . PMID: 29364886.
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    61. Persistent cytarabine and daunorubicin exposure after administration of novel liposomal formulation CPX-351: population pharmacokinetic assessment. Cancer Chemother Pharmacol. 2018 01; 81(1):171-178. Nikanjam M, Capparelli EV, Lancet JE, Louie A, Schiller G. PMID: 29167924.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    62. External Evaluation of Two Fluconazole Infant Population Pharmacokinetic Models. Antimicrob Agents Chemother. 2017 12; 61(12). Hwang MF, Beechinor RJ, Wade KC, Benjamin DK, Smith PB, Hornik CP, Capparelli EV, Duara S, Kennedy KA, Cohen-Wolkowiez M, Gonzalez D. PMID: 28893774.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    63. Prevention and treatment of HIV infection in neonates: evidence base for existing WHO dosing recommendations and implementation considerations. Expert Rev Clin Pharmacol. 2018 Jan; 11(1):83-93. Clarke DF, Penazzato M, Capparelli E, Cressey TR, Siberry G, Sugandhi N, Mirochnick M, WHO Paediatric Antiretroviral Working Group . PMID: 29039686.
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    64. Development of Tolerance to Chronic Intermittent Furosemide Therapy in Pediatric Patients. J Pediatr Pharmacol Ther. 2017 Nov-Dec; 22(6):394-398. Kim GJ, Capparelli E, Romanowski G, Proudfoot JA, Tremoulet AH. PMID: 29290738.
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    65. Pharmacokinetics of single-dose ceftaroline fosamil in children with cystic fibrosis. Pediatr Pulmonol. 2017 Nov; 52(11):1424-1434. Le J, Bradley JS, Hingtgen S, Skochko S, Black N, Jones RN, Lim M, Capparelli EV. PMID: 28910514.
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    66. Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates. . 2017 08 15; 75(5):554-560. Cressey TR, Punyawudho B, Le Coeur S, Jourdain G, Saenjum C, Capparelli EV, Jittayanun K, Phanomcheong S, Luvira A, Borkird T, Puangsombat A, Aarons L, Sukrakanchana PO, Urien S, Lallemant M, PHPT-5 study team . PMID: 28489732.
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    67. Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus. Clin Pharmacokinet. 2017 08; 56(8):941-951. Gonzalez D, Chamberlain JM, Guptill JT, Cohen-Wolkowiez M, Harper B, Zhao J, Capparelli EV, Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee . PMID: 27943220.
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    68. Basis and Statistical Design of the Passive HIV-1 Antibody Mediated Prevention (AMP) Test-of-Concept Efficacy Trials. Stat Commun Infect Dis. 2017 Jan; 9(1). Gilbert PB, Juraska M, deCamp AC, Karuna S, Edupuganti S, Mgodi N, Donnell DJ, Bentley C, Sista N, Andrew P, Isaacs A, Huang Y, Zhang L, Capparelli E, Kochar N, Wang J, Eshleman SH, Mayer KH, Magaret CA, Hural J, Kublin JG, Gray G, Montefiori DC, Gomez MM, Burns DN, McElrath J, Ledgerwood J, Graham BS, Mascola JR, Cohen M, Corey L. PMID: 29218117.
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    69. Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial. Ann Clin Transl Neurol. 2017 07; 4(7):491-505. Naviaux RK, Curtis B, Li K, Naviaux JC, Bright AT, Reiner GE, Westerfield M, Goh S, Alaynick WA, Wang L, Capparelli EV, Adams C, Sun J, Jain S, He F, Arellano DA, Mash LE, Chukoskie L, Lincoln A, Townsend J. PMID: 28695149.
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    70. CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection. AIDS. 2017 05 15; 31(8):1129-1136. Bolton Moore C, Capparelli EV, Samson P, Bwakura-Dangarembizi M, Jean-Philippe P, Worrell C, Heckman B, Purdue L, Spector SA, Benns A, Borkowsky W, Loftis A, Hawkins E, Wallis C, Chadwick EG, IMPAACT P1070 team . PMID: 28323755.
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    71. Population Pharmacokinetics of Dexmedetomidine in Infants. J Clin Pharmacol. 2017 09; 57(9):1174-1182. Greenberg RG, Wu H, Laughon M, Capparelli E, Rowe S, Zimmerman KO, Smith PB, Cohen-Wolkowiez M. PMID: 28444697.
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    72. Population pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults. MAbs. 2017 07; 9(5):792-800. Huang Y, Zhang L, Ledgerwood J, Grunenberg N, Bailer R, Isaacs A, Seaton K, Mayer KH, Capparelli E, Corey L, Gilbert PB. PMID: 28368743.
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    73. Utility of Spot Urine Specimens to Assess Tubular Secretion. Am J Kidney Dis. 2017 May; 69(5):709-711. Garimella PS, Li K, Naviaux JC, Shlipak MG, Abdelmalek JA, Castro E, Capparelli EV, Naviaux RK, Ix JH. PMID: 28284759.
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    74. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 01; 61(1). Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. PMID: 27821451.
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    75. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. N Engl J Med. 2016 11 24; 375(21):2037-2050. Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW. PMID: 27959728.
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    76. Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients. J Antimicrob Chemother. 2017 02; 72(2):490-495. Bouazza N, Cressey TR, Foissac F, Bienczak A, Denti P, McIlleron H, Burger D, Penazzato M, Lallemant M, Capparelli EV, Treluyer JM, Urien S. PMID: 27798221.
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    77. Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams. Antimicrob Agents Chemother. 2016 09; 60(9):5539-45. Momper JD, Capparelli EV, Wade KC, Kantak A, Dhanireddy R, Cummings JJ, Nedrelow JH, Hudak ML, Mundakel GT, Natarajan G, Gao J, Laughon M, Smith PB, Benjamin DK. PMID: 27401564.
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    78. Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates. J Pediatr. 2016 Nov; 178:125-129.e1. Hornik CP, Benjamin DK, Smith PB, Pencina MJ, Tremoulet AH, Capparelli EV, Ericson JE, Clark RH, Cohen-Wolkowiez M, Best Pharmaceuticals for Children Act—Pediatric Trials Network . PMID: 27522443.
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    79. Etravirine Pharmacokinetics in HIV-Infected Pregnant Women. Front Pharmacol. 2016; 7:239. Mulligan N, Schalkwijk S, Best BM, Colbers A, Wang J, Capparelli EV, Moltó J, Stek AM, Taylor G, Smith E, Hidalgo Tenorio C, Chakhtoura N, van Kasteren M, Fletcher CV, Mirochnick M, Burger D. PMID: 27540363.
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    80. Association of concurrent acid-suppression therapy with survival outcomes and adverse event incidence in oncology patients receiving erlotinib. Cancer Chemother Pharmacol. 2016 Aug; 78(2):427-32. Lam LH, Capparelli EV, Kurzrock R. PMID: 27372908.
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    81. Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women. . 2016 07 01; 72(3):289-96. Tran AH, Best BM, Stek A, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, George K, Cressey TR, Chakhtoura N, Smith E, Shapiro DE, Mirochnick M, IMPAACT P1026s Protocol Team . PMID: 26918544.
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    82. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016 07; 157(7):1499-1507. Atkinson JH, Slater MA, Capparelli EV, Patel SM, Wolfson T, Gamst A, Abramson IS, Wallace MS, Funk SD, Rutledge TR, Wetherell JL, Matthews SC, Zisook S, Garfin SR. PMID: 26963844.
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    83. Pharmacokinetics, Safety and Tolerability of Single Oral or Intravenous Administration of 200 mg Tedizolid Phosphate in Adolescents. Pediatr Infect Dis J. 2016 06; 35(6):628-33. Bradley JS, Flanagan SD, Arrieta AC, Jacobs R, Capparelli E, Prokocimer P. PMID: 26910588.
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    84. Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms. Antimicrob Agents Chemother. 2016 Apr; 60(4):2150-6. Shoji K, Bradley JS, Reed MD, van den Anker JN, Domonoske C, Capparelli EV. PMID: 26810655.
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    85. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci Transl Med. 2015 12 23; 7(319):319ra206. Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P, Enama ME, Plummer S, Holman L, Hendel CS, Gordon I, Casazza J, Conan-Cibotti M, Migueles SA, Tressler R, Bailer RT, McDermott A, Narpala S, O'Dell S, Wolf G, Lifson JD, Freemire BA, Gorelick RJ, Pandey JP, Mohan S, Chomont N, Fromentin R, Chun TW, Fauci AS, Schwartz RM, Koup RA, Douek DC, Hu Z, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE, VRC 601 Study Team . PMID: 26702094.
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    86. Optimizing drugs to reach treatment targets for children and adolescents living with HIV. J Int AIDS Soc. 2015; 18(Suppl 6):20270. Penazzato M, Lee J, Capparelli E, Essajee S, Ford N, Ojoo A, Pascual F, Sugandhi N, Lallemant M. PMID: 26639117.
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    87. Pharmacokinetics of Once Versus Twice Daily Darunavir in Pregnant HIV-Infected Women. . 2015 Sep 01; 70(1):33-41. Stek A, Best BM, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, Cressey TR, Mofenson LM, Smith E, Shapiro D, Mirochnick M. PMID: 25950206.
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    88. Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants. Clin Infect Dis. 2015 Dec 15; 61(12):1862-70. Uprety P, Chadwick EG, Rainwater-Lovett K, Ziemniak C, Luzuriaga K, Capparelli EV, Yenokyan G, Persaud D. PMID: 26270687.
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    89. Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women. Clin Infect Dis. 2015 Nov 15; 61(10):1582-9. Colbers A, Best B, Schalkwijk S, Wang J, Stek A, Hidalgo Tenorio C, Hawkins D, Taylor G, Kreitchmann R, Burchett S, Haberl A, Kabeya K, van Kasteren M, Smith E, Capparelli E, Burger D, Mirochnick M, PANNA Network and the IMPAACT 1026 Study Team . PMID: 26202768.
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    90. Bayesian Estimation of Vancomycin Pharmacokinetics in Obese Children: Matched Case-Control Study. Clin Ther. 2015 Jun 01; 37(6):1340-51. Le J, Capparelli EV, Wahid U, Wu YS, Romanowski GL, Tran TM, Nguyen A, Bradley JS. PMID: 26031618.
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    91. Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation. Antimicrob Agents Chemother. 2015 Jul; 59(7):3935-43. Watt KM, Gonzalez D, Benjamin DK, Brouwer KL, Wade KC, Capparelli E, Barrett J, Cohen-Wolkowiez M. PMID: 25896706.
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    92. The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda. Pediatr Infect Dis J. 2015 Mar; 34(3):e63-70. Bartelink IH, Savic RM, Dorsey G, Ruel T, Gingrich D, Scherpbier HJ, Capparelli E, Jullien V, Young SL, Achan J, Plenty A, Charlebois E, Kamya M, Havlir D, Aweeka F. PMID: 25742090.
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    93. Adverse Event Detection and Labeling in Pediatric Drug Development: Antiretroviral Drugs. Ther Innov Regul Sci. 2015 Mar; 49(2):302-309. Momper JD, Chang Y, Jackson M, Schuette P, Seo S, Younis I, Abernethy DR, Yao L, Capparelli EV, Burckart GJ. PMID: 30222418.
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    94. Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing. Cancer Chemother Pharmacol. 2015 Mar; 75(3):495-503. Nikanjam M, Stewart CF, Takimoto CH, Synold TW, Beaty O, Fouladi M, Capparelli EV. PMID: 25557868.
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    95. Raltegravir pharmacokinetics during pregnancy. . 2014 Dec 01; 67(4):375-81. Watts DH, Stek A, Best BM, Wang J, Capparelli EV, Cressey TR, Aweeka F, Lizak P, Kreitchmann R, Burchett SK, Shapiro DE, Hawkins E, Smith E, Mirochnick M, IMPAACT 1026s study team . PMID: 25162818.
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    96. Pharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children. J Pediatric Infect Dis Soc. 2015 Dec; 4(4):e109-16. Le J, Ny P, Capparelli E, Lane J, Ngu B, Muus R, Romanowski G, Vo T, Bradley J. PMID: 26582878.
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    97. Variable and suboptimal nevirapine levels in infants given single-dose nevirapine at birth without maternal prophylaxis. AIDS. 2014 Oct 23; 28(16):2491-3. Dross SE, Rossi SS, Beck IA, Micek MA, Blanco AJ, Seidel KD, Montoya P, Capparelli EV, Frenkel LM. PMID: 25265235.
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    98. Lopinavir/ritonavir plus lamivudine and abacavir or zidovudine dose ratios for paediatric fixed-dose combinations. Antivir Ther. 2015; 20(2):225-33. Bouazza N, Foissac F, Fauchet F, Burger D, Kiechel JR, Treluyer JM, Capparelli EV, Lallemant M, Urien S. PMID: 25279808.
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    99. Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia. Ther Drug Monit. 2014 Oct; 36(5):584-9. Sampson MR, Frymoyer A, Rattray B, Cotten CM, Smith PB, Capparelli E, Bonifacio SL, Cohen-Wolkowiez M. PMID: 25225917.
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    100. Optimizing pediatric esmolol dosing using computerized practitioner order entry. J Pediatr Pharmacol Ther. 2014 Oct-Dec; 19(4):302-9. Chao T, Perry JC, Romanowski GL, Tremoulet AH, Capparelli EV. PMID: 25762876.
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    101. Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections. Pediatr Infect Dis J. 2014 Oct; 33(10):e270-2. Autmizguine J, Moran C, Gonzalez D, Capparelli EV, Smith PB, Grant GA, Benjamin DK, Cohen-Wolkowiez M, Watt KM. PMID: 24776517.
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    102. Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy. J Antimicrob Chemother. 2015 Jan; 70(1):217-24. Cressey TR, Urien S, Capparelli EV, Best BM, Buranabanjasatean S, Limtrakul A, Rawangban B, Sabsanong P, Treluyer JM, Jourdain G, Stek A, Lallemant M, Mirochnick M. PMID: 25261418.
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    103. Vancomycin monitoring in children using bayesian estimation. Ther Drug Monit. 2014 Aug; 36(4):510-8. Le J, Ngu B, Bradley JS, Murray W, Nguyen A, Nguyen L, Romanowski GL, Vo T, Capparelli EV. PMID: 24452067.
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    104. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. PLoS Negl Trop Dis. 2014; 8(7):e2973. Andrade RM, Chaparro JD, Capparelli E, Reed SL. PMID: 25079790.
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    105. Pharmacokinetics and pharmacodynamics of antifungals in children: clinical implications. Drugs. 2014 Jun; 74(8):891-909. Autmizguine J, Guptill JT, Cohen-Wolkowiez M, Benjamin DK, Capparelli EV. PMID: 24872147.
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    106. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014 Jun; 58(6):3013-20. Tremoulet A, Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Salgado A, Ian-U Chong S, Melloni C, Gao J, Benjamin DK, Capparelli EV, Cohen-Wolkowiez M, Administrative Core Committee of the Best Pharmaceuticals for Children Act-Pediatric Trials Network . PMID: 24614374.
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    107. Developmental pharmacokinetics of piperacillin and tazobactam using plasma and dried blood spots from infants. Antimicrob Agents Chemother. 2014 May; 58(5):2856-65. Cohen-Wolkowiez M, Watt KM, Zhou C, Bloom BT, Poindexter B, Castro L, Gao J, Capparelli EV, Benjamin DK, Smith PB. PMID: 24614369.
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    108. Population pharmacokinetics of intravenous acyclovir in preterm and term infants. Pediatr Infect Dis J. 2014 Jan; 33(1):42-9. Sampson MR, Bloom BT, Lenfestey RW, Harper B, Kashuba AD, Anand R, Benjamin DK, Capparelli E, Cohen-Wolkowiez M, Smith PB, Best Pharmaceuticals for Children Act–Pediatric Trials Network . PMID: 24346595.
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    109. Population-Based Pharmacokinetic Modeling of Vancomycin in Children with Renal Insufficiency. J Pharmacol Clin Toxicol. 2014; 2(1):1017-1026. Le J, Vaida F, Nguyen E, Adler-Shohet FC, Romanowski G, Kim J, Vo T, Capparelli EV. PMID: 25309945.
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    110. Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants. Pediatr Infect Dis J. 2013 Sep; 32(9):956-61. Cohen-Wolkowiez M, Sampson M, Bloom BT, Arrieta A, Wynn JL, Martz K, Harper B, Kearns GL, Capparelli EV, Siegel D, Benjamin DK, Smith PB, Best Pharmaceuticals for Children Act–Pediatric Trials Network . PMID: 23587979.
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    111. Reduced indinavir exposure during pregnancy. Br J Clin Pharmacol. 2013 Sep; 76(3):475-83. Cressey TR, Best BM, Achalapong J, Stek A, Wang J, Chotivanich N, Yuthavisuthi P, Suriyachai P, Prommas S, Shapiro DE, Watts DH, Smith E, Capparelli E, Kreitchmann R, Mirochnick M, IMPAACT P1026s team . PMID: 23305215.
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    112. Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants. Pediatr Infect Dis J. 2013 Jul; 32(7):748-53. Hornik CP, Herring AH, Benjamin DK, Capparelli EV, Kearns GL, van den Anker J, Cohen-Wolkowiez M, Clark RH, Smith PB, Best Pharmaceuticals for Children Act-Pediatric Trials Network . PMID: 23838776.
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    113. Determination of efavirenz in human dried blood spots by reversed-phase high-performance liquid chromatography with UV detection. Ther Drug Monit. 2013 Apr; 35(2):203-8. Hoffman JT, Rossi SS, Espina-Quinto R, Letendre S, Capparelli EV. PMID: 23503446.
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    114. Improved vancomycin dosing in children using area under the curve exposure. Pediatr Infect Dis J. 2013 Apr; 32(4):e155-63. Le J, Bradley JS, Murray W, Romanowski GL, Tran TT, Nguyen N, Cho S, Natale S, Bui I, Tran TM, Capparelli EV. PMID: 23340565.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    115. External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings. Br J Clin Pharmacol. 2013 Apr; 75(4):1068-80. Zhao W, Kaguelidou F, Biran V, Zhang D, Allegaert K, Capparelli EV, Holford N, Kimura T, Lo YL, Peris JE, Thomson A, van den Anker JN, Fakhoury M, Jacqz-Aigrain E. PMID: 23148919.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    116. Etravirine in CSF is highly protein bound. J Antimicrob Chemother. 2013 May; 68(5):1161-8. Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S, CHARTER Group . PMID: 23335197.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    117. Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana. Antivir Ther. 2013; 18(4):585-90. Shapiro RL, Rossi S, Ogwu A, Moss M, Leidner J, Moffat C, Lockman S, Moyo S, Makhema J, Essex M, Capparelli E. PMID: 23183881.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    118. Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration. J Antimicrob Chemother. 2013 Mar; 68(3):684-9. Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S, CHARTER Group . PMID: 23143899.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    119. Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. Pediatr Infect Dis J. 2012 Oct; 31(10):1042-7. Watt KM, Benjamin DK, Cheifetz IM, Moorthy G, Wade KC, Smith PB, Brouwer KL, Capparelli EV, Cohen-Wolkowiez M. PMID: 22627870.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    120. Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections. Clin Infect Dis. 2012 Dec; 55(11):1495-502. Cohen-Wolkowiez M, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Randolph DA, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Rich W, Brozanski BS, van den Anker J, Blumer J, Laughon M, Watt KM, Kearns GL, Capparelli EV, Martz K, Berezny K, Benjamin DK, Smith PB, Meropenem Study Team . PMID: 22955430.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    121. Nevirapine exposure with WHO pediatric weight band dosing: enhanced therapeutic concentrations predicted based on extensive international pharmacokinetic experience. Antimicrob Agents Chemother. 2012 Oct; 56(10):5374-80. Nikanjam M, Kabamba D, Cressey TR, Burger D, Aweeka FT, Acosta EP, Spector SA, Capparelli EV. PMID: 22869579.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    122. Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age. AIDS. 2012 Jul 31; 26(12):1483-90. Persaud D, Palumbo PE, Ziemniak C, Hughes MD, Alvero CG, Luzuriaga K, Yogev R, Capparelli EV, Chadwick EG. PMID: 22555165.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    123. Pharmacokinetic considerations of perinatal antiretroviral therapy. Curr Drug Metab. 2012 Jul; 13(6):744-59. Rakhmanina NY, Dirajlal-Fargo S, Capparelli EV, Mirochnik M. PMID: 22452457.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    124. High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count. Ther Drug Monit. 2012 Jun; 34(3):237-41. Rakhmanina NY, Neely MN, Capparelli EV. PMID: 22549499.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    125. A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur during the first week of life. Pediatr Res. 2012 Jul; 72(1):43-9. Sharpe CM, Capparelli EV, Mower A, Farrell MJ, Soldin SJ, Haas RH. PMID: 22495532.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    126. Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir. . 2012 Apr 01; 59(4):376-81. Best BM, Letendre SL, Koopmans P, Rossi SS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Capparelli EV, Ellis RJ, Grant I, CHARTER Study Group . PMID: 22217676.
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    127. Pharmacokinetics of nevirapine in HIV and tuberculosis-coinfected children receiving antiretroviral fixed-dose combination tablets while receiving rifampicin-containing tuberculosis treatment and after rifampicin discontinuation. Pediatr Infect Dis J. 2012 Apr; 31(4):389-91. Prasitsuebsai W, Cressey TR, Capparelli E, Vanprapar N, Lapphra K, Chokephaibulkit K. PMID: 22146740.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    128. Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum. . 2012 Mar 01; 59(3):245-52. Cressey TR, Stek A, Capparelli E, Bowonwatanuwong C, Prommas S, Sirivatanapa P, Yuthavisuthi P, Neungton C, Huo Y, Smith E, Best BM, Mirochnick M, IMPAACT P1026s Team . PMID: 22083071.
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    129. Therapeutic amprenavir concentrations in cerebrospinal fluid. Antimicrob Agents Chemother. 2012 Apr; 56(4):1985-9. Croteau D, Letendre S, Best BM, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Way L, Capparelli E, Grant I, CHARTER Group . PMID: 22290964.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    130. Developmental pharmacokinetic changes of Lamivudine in infants and children. J Clin Pharmacol. 2012 Dec; 52(12):1824-32. Tremoulet AH, Nikanjam M, Cressey TR, Chokephaibulkit K, McKinney R, Mirochnick M, Capparelli EV. PMID: 22180560.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    131. Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children. . 2011 Dec 01; 58(4):385-91. Best BM, Capparelli EV, Diep H, Rossi SS, Farrell MJ, Williams E, Lee G, van den Anker JN, Rakhmanina N. PMID: 21876444.
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    132. Pharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus. J Pediatr. 2012 Apr; 160(4):667-672.e2. Chamberlain JM, Capparelli EV, Brown KM, Vance CW, Lillis K, Mahajan P, Lichenstein R, Stanley RM, Davis CO, Gordon S, Baren JM, van den Anker JN, Pediatric Emergency Care Applied Research Network (PECARN) . PMID: 22050870.
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    133. Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping. Eur J Clin Pharmacol. 2012 Apr; 68(4):407-13. Lawson EB, Wu JC, Baldwin RM, Ingelman-Sundberg M, Rosenborg S, Yim DS, Yin OQ, Capparelli EV, Ma JD. PMID: 22009190.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    134. Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections. Pediatr Infect Dis J. 2011 Oct; 30(10):844-9. Smith PB, Cohen-Wolkowiez M, Castro LM, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Bhatt-Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Brozanski BS, Sanchez P, van den Anker J, Blumer J, Kearns GL, Capparelli EV, Anand R, Benjamin DK, Meropenem Study Team . PMID: 21829139.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    135. Innovative clinical trial design for pediatric therapeutics. Expert Rev Clin Pharmacol. 2011 Sep; 4(5):643-52. Laughon MM, Benjamin DK, Capparelli EV, Kearns GL, Berezny K, Paul IM, Wade K, Barrett J, Smith PB, Cohen-Wolkowiez M. PMID: 21980319.
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    136. Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria. Malar J. 2011 May 08; 10:114. Morris CA, Onyamboko MA, Capparelli E, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright L, Tshefu AK, Meshnick S, Fleckenstein L. PMID: 21548983.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    137. Atazanavir pharmacokinetics with and without tenofovir during pregnancy. . 2011 Apr 15; 56(5):412-9. Mirochnick M, Best BM, Stek AM, Capparelli EV, Hu C, Burchett SK, Rossi SS, Hawkins E, Basar M, Smith E, Read JS, IMPAACT 1026s Study Team . PMID: 21283017.
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    138. Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy. AIDS. 2011 Mar 13; 25(5):643-9. Chadwick EG, Yogev R, Alvero CG, Hughes MD, Hazra R, Pinto JA, Robbins BL, Heckman BE, Palumbo PE, Capparelli EV, International Pediatric Adolescent Clinical Trials Group (IMPAACT) P1030 Team . PMID: 21297419.
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    139. Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC. Malar J. 2011 Feb 28; 10:49. Onyamboko MA, Meshnick SR, Fleckenstein L, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright LL, Tshefu AK, Capparelli EV. PMID: 21352601.
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    140. Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):198-202. Barshop NJ, Capparelli EV, Sirlin CB, Schwimmer JB, Lavine JE. PMID: 21240014.
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    141. Bioequivalence of dispersed stavudine: opened versus closed capsule dosing. Antivir Ther. 2011; 16(7):1131-4. Innes S, Norman J, Smith P, Smuts M, Capparelli E, Rosenkranz B, Cotton M. PMID: 22024529.
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    142. Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine in HIV-infected children. Antivir Ther. 2011; 16(8):1287-95. Chokephaibulkit K, Cressey TR, Capparelli E, Sirisanthana V, Muresan P, Hongsiriwon S, Ngampiyaskul C, Limwongse C, Wittawatmongkol O, Aurpibul L, Kabat B, Toye M, Smith ME, Eksaengsri A, McIntosh K, Yogev R, IMPAACT P1069 Team . PMID: 22155910.
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    143. Efavirenz concentrations in CSF exceed IC50 for wild-type HIV. J Antimicrob Chemother. 2011 Feb; 66(2):354-7. Best BM, Koopmans PP, Letendre SL, Capparelli EV, Rossi SS, Clifford DB, Collier AC, Gelman BB, Mbeo G, McCutchan JA, Simpson DM, Haubrich R, Ellis R, Grant I, CHARTER Group . PMID: 21098541.
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    144. A chewable pediatric fixed-dose combination tablet of stavudine, lamivudine, and nevirapine: pharmacokinetics and safety compared with the individual liquid formulations in human immunodeficiency virus-infected children in Thailand. Pediatr Infect Dis J. 2010 Oct; 29(10):940-4. Vanprapar N, Cressey TR, Chokephaibulkit K, Muresan P, Plipat N, Sirisanthana V, Prasitsuebsai W, Hongsiriwan S, Chotpitayasunondh T, Eksaengsri A, Toye M, Smith ME, McIntosh K, Capparelli E, Yogev R, IMPAACT P1056 Team . PMID: 20453709.
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    145. Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1. Antimicrob Agents Chemother. 2010 Dec; 54(12):5156-60. Croteau D, Letendre S, Best BM, Ellis RJ, Breidinger S, Clifford D, Collier A, Gelman B, Marra C, Mbeo G, McCutchan A, Morgello S, Simpson D, Way L, Vaida F, Ueland S, Capparelli E, Grant I, CHARTER Group . PMID: 20876368.
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    146. Lopinavir tablet pharmacokinetics with an increased dose during pregnancy. . 2010 Aug; 54(4):381-8. Best BM, Stek AM, Mirochnick M, Hu C, Li H, Burchett SK, Rossi SS, Smith E, Read JS, Capparelli EV, International Maternal Pediatric Adolescent AIDS Clinical Trials Group 1026s Study Team . PMID: 20632458.
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    147. CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy. . 2010 Jul; 54(3):285-9. Saitoh A, Capparelli E, Aweeka F, Sarles E, Singh KK, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton T, Spector SA. PMID: 19890215.
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    148. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 04; 362(9):790-9. Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC, Childhood Absence Epilepsy Study Group . PMID: 20200383.
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    149. Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women. J Antimicrob Chemother. 2009 Dec; 64(6):1265-73. Chantarangsu S, Cressey TR, Mahasirimongkol S, Capparelli E, Tawon Y, Ngo-Giang-Huong N, Jourdain G, Lallemant M, Chantratita W. PMID: 19812066.
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    150. Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos. 2009 Aug; 37(8):1779-84. James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM. PMID: 19439490.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    151. Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: a randomized, placebo-controlled, single-blind, dose-escalation, crossover study. Clin Ther. 2009 Apr; 31(4):806-15. Malloy J, Capparelli E, Gottschalk M, Guan X, Kothare P, Fineman M. PMID: 19446153.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    152. Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr. 2009 Apr; 21(2):177-81. Cohen-Wolkowiez M, Benjamin DK, Capparelli E. PMID: 19276977.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    153. Is there a therapeutic window with some antidepressants for analgesic response? Curr Pain Headache Rep. 2009 Apr; 13(2):93-9. Atkinson JH, Patel SM, Meyer JM, Slater MA, Zisook S, Capparelli E. PMID: 19272274.
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    154. Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacy. Pediatr Infect Dis J. 2009 Mar; 28(3):215-9. Chadwick EG, Pinto J, Yogev R, Alvero CG, Hughes MD, Palumbo P, Robbins B, Hazra R, Serchuck L, Heckman BE, Purdue L, Browning R, Luzuriaga K, Rodman J, Capparelli E, International Maternal Pediatric Adolescent Clinical Trials Group (IMPAACT) P1030 Team . PMID: 19209098.
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    155. Low atazanavir concentrations in cerebrospinal fluid. AIDS. 2009 Jan 02; 23(1):83-7. Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli EV, Grant I, CHARTER Group . PMID: 19050389.
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    156. Antiretroviral concentrations in breast-feeding infants of mothers receiving highly active antiretroviral therapy. Antimicrob Agents Chemother. 2009 Mar; 53(3):1170-6. Mirochnick M, Thomas T, Capparelli E, Zeh C, Holland D, Masaba R, Odhiambo P, Fowler MG, Weidle PJ, Thigpen MC. PMID: 19114673.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    157. Lopinavir exposure with an increased dose during pregnancy. . 2008 Dec 15; 49(5):485-91. Mirochnick M, Best BM, Stek AM, Capparelli E, Hu C, Burchett SK, Holland DT, Smith E, Gaddipati S, Read JS, PACTG 1026s Study Team . PMID: 18989231.
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    158. Rapid weight gain in children soon after diagnosis of type 1 diabetes: is there room for concern? Pediatr Diabetes. 2009 Aug; 10(5):310-5. Newfield RS, Cohen D, Capparelli EV, Shragg P. PMID: 19067888.
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    159. Nitazoxanide treatment of Cryptosporidium parvum in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 2008 Nov; 27(11):1041. Capparelli EV, Syed SS. PMID: 18818555.
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    160. Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate. Pediatr Infect Dis J. 2008 Sep; 27(9):794-9. Bradley JS, Sauberan JB, Ambrose PG, Bhavnani SM, Rasmussen MR, Capparelli EV. PMID: 18645546.
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    161. Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2008 Dec; 153(6):833-8. Burns JC, Best BM, Mejias A, Mahony L, Fixler DE, Jafri HS, Melish ME, Jackson MA, Asmar BI, Lang DJ, Connor JD, Capparelli EV, Keen ML, Mamun K, Keenan GF, Ramilo O. PMID: 18672254.
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    162. Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors. Antimicrob Agents Chemother. 2008 Sep; 52(9):3276-83. Robbins BL, Capparelli EV, Chadwick EG, Yogev R, Serchuck L, Worrell C, Smith ME, Alvero C, Fenton T, Heckman B, Pelton SI, Aldrovandi G, Borkowsky W, Rodman J, Havens PL, PACTG 1038 Team . PMID: 18625762.
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    163. Implications of gender and pregnancy for antiretroviral drug dosing. Curr Opin HIV AIDS. 2008 May; 3(3):277-82. Best BM, Capparelli EV. PMID: 19372979.
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    164. Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics. HIV Med. 2008 Apr; 9(4):214-20. Capparelli EV, Aweeka F, Hitti J, Stek A, Hu C, Burchett SK, Best B, Smith E, Read JS, Watts H, Nachman S, Thorpe EM, Spector SA, Jimenez E, Shearer WT, Foca M, Mirochnick M, PACTG 1026S Study Team , PACTG P1022 Study Team . PMID: 18366444.
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    165. Planned multiple exposures to autologous virus in HIV type 1-infected pediatric populations increases HIV-specific immunity and reduces HIV viremia. AIDS Res Hum Retroviruses. 2008 Mar; 24(3):401-11. Borkowsky W, Yogev R, Muresan P, McFarland E, Frenkel L, Fenton T, Capparelli E, Moye J, Harding P, Ellis N, Heckman B, Kraimer J. PMID: 18327977.
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    166. UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Am J Hematol. 2008 Mar; 83(3):200-2. Darbari DS, van Schaik RH, Capparelli EV, Rana S, McCarter R, van den Anker J. PMID: 17724700.
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    167. Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results. AIDS. 2008 Jan 11; 22(2):249-55. Chadwick EG, Capparelli EV, Yogev R, Pinto JA, Robbins B, Rodman JH, Chen J, Palumbo P, Serchuck L, Smith E, Hughes M, P1030 team . PMID: 18097227.
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    168. Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol. 2008 Jan; 65(1):65-70. Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ, CHARTER Group . PMID: 18195140.
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    169. A randomized controlled trial of therapeutic drug monitoring in treatment-naive and -experienced HIV-1-infected patients. . 2007 Dec 01; 46(4):433-42. Best BM, Goicoechea M, Witt MD, Miller L, Daar ES, Diamond C, Tilles JG, Kemper CA, Larsen R, Holland DT, Sun S, Jain S, Wagner G, Capparelli EV, McCutchan JA, Haubrich RH, California Collaborative Treatment Group 578 Study Team . PMID: 17786128.
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    170. CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS. 2007 Oct 18; 21(16):2191-9. Saitoh A, Sarles E, Capparelli E, Aweeka F, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton T, Spector SA. PMID: 18090046.
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    171. Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants. Antimicrob Agents Chemother. 2007 Dec; 51(12):4297-302. Tremoulet AH, Capparelli EV, Patel P, Acosta EP, Luzuriaga K, Bryson Y, Wara D, Zorrilla C, Holland D, Mirochnick M, Pediatric AIDS Clinical Trials Group . PMID: 17893155.
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    172. Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study. Pediatr Crit Care Med. 2007 Sep; 8(5):419-24. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Díaz SM, Rodarte A, Foley J, Capparelli EV. PMID: 17693909.
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    173. Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents. Antimicrob Agents Chemother. 2007 Oct; 51(10):3516-22. Flynn PM, Rodman J, Lindsey JC, Robbins B, Capparelli E, Knapp KM, Rodriguez JF, McNamara J, Serchuck L, Heckman B, Martinez J, PACTG P1012 Team . PMID: 17664328.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    174. Pharmacologic, pharmacodynamic, and pharmacokinetic considerations with intravenous Ibuprofen lysine. J Pediatr Pharmacol Ther. 2007 Jul; 12(3):158-70. Capparelli EV. PMID: 23055851.
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    175. Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. J Clin Psychopharmacol. 2007 Apr; 27(2):135-42. Atkinson JH, Slater MA, Capparelli EV, Wallace MS, Zisook S, Abramson I, Matthews SC, Garfin SR. PMID: 17414235.
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    176. Nevirapine concentration in nonstimulated saliva: an alternative to plasma sampling in children with human immunodeficiency virus infection. Ther Drug Monit. 2007 Feb; 29(1):110-7. Rakhmanina NY, Capparelli EV, van den Anker JN, Williams K, Sever JL, Spiegel HM, Soldin SJ. PMID: 17304158.
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    177. Population pharmacokinetic model for gatifloxacin in pediatric patients. Antimicrob Agents Chemother. 2007 Apr; 51(4):1246-52. Rubino CM, Capparelli EV, Bradley JS, Blumer JL, Kearns GL, Reed M, Jacobs RF, Cirincione B, Grasela DM. PMID: 17220409.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    178. Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS. J Neuroimmune Pharmacol. 2007 Mar; 2(1):97-104. May S, Letendre S, Haubrich R, McCutchan JA, Heaton R, Capparelli E, Ellis R. PMID: 18040832.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    179. A computer-based system to aid in the interpretation of plasma concentrations of antiretrovirals for therapeutic drug monitoring. Antivir Ther. 2007; 12(1):55-62. Goicoechea M, Vidal A, Capparelli E, Rigby A, Kemper C, Diamond C, Witt MD, Haubrich R, California Collaborative Treatment Group . PMID: 17503748.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    180. Therapeutic ritonavir-boosted atazanavir plasma concentration and concurrent omeprazole use. AIDS. 2006 Oct 24; 20(16):2127-8. Goicoechea M, Best B, Capparelli E, Caperna J, Ballard C, Haubrich R. PMID: 17053363.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    181. Reduced lopinavir exposure during pregnancy. AIDS. 2006 Oct 03; 20(15):1931-9. Stek AM, Mirochnick M, Capparelli E, Best BM, Hu C, Burchett SK, Elgie C, Holland DT, Smith E, Tuomala R, Cotter A, Read JS. PMID: 16988514.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCellsCTClinical Trials
    182. Concurrent use of efavirenz and oxcarbazepine may not affect efavirenz plasma concentrations. Clin Infect Dis. 2006 Jul 01; 43(1):116-7. Goicoechea M, Best B, Capparelli E, Haubrich R, California Collaborative Treatment Group . PMID: 16758435.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    183. Failure of modified directly observed therapy combined with therapeutic drug monitoring to enhance antiretroviral adherence in a patient with major depression. AIDS Patient Care STDS. 2006 Apr; 20(4):233-7. Goicoechea M, Best B, Seefried E, Wagner G, Capparelli E, Haubrich R, California Collaborative Treatment Group (CCTG) . PMID: 16623621.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    184. Population pharmacokinetics of troxacitabine, a novel dioxolane nucleoside analogue. Clin Cancer Res. 2006 Apr 01; 12(7 Pt 1):2158-65. Lee CK, Rowinsky EK, Li J, Giles F, Moore MJ, Hidalgo M, Capparelli E, Jolivet J, Baker SD. PMID: 16609029.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    185. Summary proceedings from the neonatal pain-control group. Pediatrics. 2006 Mar; 117(3 Pt 2):S9-S22. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo W, Hummel P, Johnston CC, Lantos J, Tutag-Lehr V, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. PMID: 16777824.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    186. Impact of pregnancy on abacavir pharmacokinetics. AIDS. 2006 Feb 28; 20(4):553-60. Best BM, Mirochnick M, Capparelli EV, Stek A, Burchett SK, Holland DT, Read JS, Smith E, Hu C, Spector SA, Connor JD, PACTG P1026s Study Team . PMID: 16470119.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    187. Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants. Antimicrob Agents Chemother. 2005 Oct; 49(10):4121-7. Capparelli EV, Bloom BT, Kueser TJ, Oelberg DG, Bifano EM, White RD, Schelonka RL, Pearlman SA, Patti J, Hetherington SV. PMID: 16189088.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    188. Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes. J Clin Pharmacol. 2005 Oct; 45(10):1137-44. Christensen ML, Meibohm B, Capparelli EV, Velasquez-Mieyer P, Burghen GA, Tamborlane WV. PMID: 16172178.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    189. Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination of stavudine, lamivudine and nevirapine. AIDS. 2005 Sep 23; 19(14):1495-9. Chokephaibulkit K, Plipat N, Cressey TR, Frederix K, Phongsamart W, Capparelli E, Kolladarungkri T, Vanprapar N. PMID: 16135903.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    190. Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment. J Infect Dis. 2005 Sep 01; 192(5):720-7. Shapiro RL, Holland DT, Capparelli E, Lockman S, Thior I, Wester C, Stevens L, Peter T, Essex M, Connor JD, Mirochnick M. PMID: 16088821.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCellsCTClinical Trials
    191. Instability of lopinavir/ritonavir capsules at ambient temperatures in sub-Saharan Africa: relevance to WHO antiretroviral guidelines. AIDS. 2005 Jul 22; 19(11):1233-4. Pau AK, Moodley NK, Holland DT, Fomundam H, Matchaba GU, Capparelli EV. PMID: 15990580.
      View in: PubMed   Mentions: 2     Fields:    
    192. Population pharmacokinetics of cefepime in the neonate. Antimicrob Agents Chemother. 2005 Jul; 49(7):2760-6. Capparelli E, Hochwald C, Rasmussen M, Parham A, Bradley J, Moya F. PMID: 15980347.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    193. Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response. J Infect Dis. 2005 Jul 15; 192(2):296-302. Kovacs A, Montepiedra G, Carey V, Pahwa S, Weinberg A, Frenkel L, Capparelli E, Mofenson L, Smith E, McIntosh K, Burchett SK, Pediatric AIDS Clinical Trials Group 366 Study Team . PMID: 15962224.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    194. Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV. AIDS. 2005 Jun 10; 19(9):949-52. Capparelli EV, Holland D, Okamoto C, Gragg B, Durelle J, Marquie-Beck J, van den Brande G, Ellis R, Letendre S, HNRC Group . PMID: 15905676.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    195. Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life. Pediatr Infect Dis J. 2005 Jun; 24(6):503-9. Kovacs A, Cowles MK, Britto P, Capparelli E, Fowler MG, Moye J, McIntosh K, Rathore MH, Pitt J, Husson RN. PMID: 15933559.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    196. Safety and pharmacokinetics of nelfinavir coadministered with zidovudine and lamivudine in infants during the first 6 weeks of life. . 2005 Jun 01; 39(2):189-94. Mirochnick M, Stek A, Acevedo M, Keller M, Holland D, Capparelli E, Connor J, Huang S, Hughes M, Watts H, Mofenson L, Bryson Y. PMID: 15905735.
      View in: PubMed   Mentions:
    197. Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid. Antimicrob Agents Chemother. 2005 Jun; 49(6):2504-6. Capparelli EV, Letendre SL, Ellis RJ, Patel P, Holland D, McCutchan JA. PMID: 15917556.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsCTClinical Trials
    198. Analgesia and anesthesia for neonates: study design and ethical issues. Clin Ther. 2005 Jun; 27(6):814-43. Anand KJ, Aranda JV, Berde CB, Buckman S, Capparelli EV, Carlo WA, Hummel P, Lantos J, Johnston CC, Lehr VT, Lynn AM, Maxwell LG, Oberlander TF, Raju TN, Soriano SG, Taddio A, Walco GA. PMID: 16117988.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    199. Pharmacokinetics of gatifloxacin in infants and children. Antimicrob Agents Chemother. 2005 Mar; 49(3):1106-12. Capparelli EV, Reed MD, Bradley JS, Kearns GL, Jacobs RF, Damle BD, Blumer JL, Grasela DM. PMID: 15728910.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    200. Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1. . 2005 Mar 01; 38(3):283-8. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Cressey TR, Jourdain G, Lallemant MJ, Kunkeaw S, Jackson JB, Musoke P, Capparelli E, Mirochnick M. PMID: 15735445.
      View in: PubMed   Mentions:
    201. Pharmacotherapy of perinatal HIV. Semin Fetal Neonatal Med. 2005 Apr; 10(2):161-75. Capparelli E, Rakhmanina N, Mirochnick M. PMID: 15701581.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    202. The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patients. Antivir Ther. 2004 Oct; 9(5):753-61. Yasuda JM, Miller C, Currier JS, Forthal DN, Kemper CA, Beall GN, Tilles JG, Capparelli EV, McCutchan JA, Haubrich RH, California Collaborative Treatment Group . PMID: 15535413.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    203. Pharmacokinetics of antiretrovirals in pregnant women. Clin Pharmacokinet. 2004; 43(15):1071-87. Mirochnick M, Capparelli E. PMID: 15568888.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    204. Model appropriateness and population pharmacokinetic modeling. J Clin Pharmacol. 2003 Jun; 43(6):610-23. Ette EI, Williams PJ, Kim YH, Lane JR, Liu MJ, Capparelli EV. PMID: 12817524.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    205. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J. 2003 Apr; 22(4):335-41. Abzug MJ, Cloud G, Bradley J, Sánchez PJ, Romero J, Powell D, Lepow M, Mani C, Capparelli EV, Blount S, Lakeman F, Whitley RJ, Kimberlin DW, National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group . PMID: 12690273.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    206. Pharmacokinetic and tolerability assessment of a pediatric oral formulation of pentoxifylline in kawasaki disease. Curr Ther Res Clin Exp. 2003 Feb; 64(2):96-115. Best BM, Burns JC, DeVincenzo J, Phelps SJ, Blumer JL, Wilson JT, Capparelli EV, Connor JD, Pediatric Pharmacology Research Unit Network . PMID: 24944359.
      View in: PubMed   Mentions: 2     Fields:    
    207. Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children. J Clin Pharmacol. 2003 Feb; 43(2):133-40. Capparelli EV, Englund JA, Connor JD, Spector SA, McKinney RE, Palumbo P, Baker CJ. PMID: 12616665.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    208. Pharmacokinetics and tolerance of zidovudine in preterm infants. J Pediatr. 2003 Jan; 142(1):47-52. Capparelli EV, Mirochnick M, Dankner WM, Blanchard S, Mofenson L, McSherry GD, Gay H, Ciupak G, Smith B, Connor JD, Pediatric AIDS Clinical Trials Group 331 Investigators . PMID: 12520254.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    209. A phase I study of AIT-082 in healthy elderly volunteers. J Mol Neurosci. 2002 Jun; 18(3):283-93. Grundman M, Farlow M, Peavy G, Kim HT, Capparelli E, Schultz AN, Salmon DP, Ferris SH, Mobs R, Thomas RG, Schafer K, Campbell K, Hake AM, Schoos B, Thal LJ, Alzheimer's Disease Cooperative Study . PMID: 12059047.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
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