Maile Karris

TitleAssociate Clinical Professor
InstitutionUniversity of California San Diego
Address200 W. Arbor Drive #8208
San Diego CA 92103
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    Collapse Biography 
    Collapse Education and Training
    University of California San Diego, San Diego06/2010Infectious Diseases/HIV
    Oregon Health and Sciences, Portland, OR06/2006Internal Medicine
    John A Burns School of Medicine, Honolulu, HIMD06/2003
    Collapse Awards and Honors
    National Institute of Aging2017Butler Williams Scholars Program
    Conference on Retroviruses and Opportunistic Infections2012Young Investigator Award
    Conference on Retroviruses and Opportunistic Infections2010Young Investigator Award

    Collapse Overview 
    Collapse Overview
    I am a board certified internal medicine and infectious diseases physician who has been caring for persons living with HIV since 2004. I care for a variety of persons living with HIV but have a special interest in persons newly diagnosed, in the successful aging of persons living with HIV, and in HIV prevention (pre-exposure prophylaxis or PrEP).

    I am an Associate Professor of Medicine in the Division of Infectious Diseases and Global Public Health and participate in clinical and translational HIV research at the AntViral Research Center and through the Center For AIDS Research (CFAR). As a member of the leadership team of the CFAR Clinical Investigation Core I assist investigators in the performance of clinical and translational HIV research by assisting with study design, study implementation, participant recruitment, research regulatory processes, and data safety monitoring. Our Core also allows the generation of preliminary data and the performance of patient oriented research through our linked patient database and specimen repository.

    Currently, my research interests stem from the “bedside-to-bench”, in that I pursue research questions that directly respond to the day-to-day needs of my patients. Examples of my current research interests include a better understanding the barriers and facilitators that contribute to poor HIV linkage and retention, a better understanding of the biology and delivery of PrEP for HIV prevention and the impact of inflammation and other factors on the successful aging of persons living with HIV.

    I also participate in the mentoring and education of medicine residents and infectious diseases fellows historically participating in UCSD’s medical microbiology and HIV pharmacology courses along with weekly educational conferences in the departments of medicine and infectious diseases along with community-based and international lecturing on various HIV topics.

    Collapse Research 
    Collapse Research Activities and Funding
    Effect of Sex Hormones on HIV persistence
    NIH R21AI134295Jun 26, 2017 - May 31, 2019
    Role: Co-Investigator
    Sexual trauma and HIV susceptibility among women: the role of stress and genital immunity
    NIH/NIAID R01AI128803Jun 20, 2017 - May 31, 2021
    Role: Co-Investigator
    Center for AIDS Research
    NIH/NIAID P30AI036214Apr 1, 1994 - Mar 31, 2023
    Role: CFAR Clinical Investigations Core Leadership Trainee

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pines HA, Karris M, Little SJ. Sexual Partner Concurrency Among Partners Reported by MSM with Recent HIV Infection. AIDS Behav. 2017 Oct; 21(10):3026-3034. PMID: 28702851.
      View in: PubMed
    2. Karris M. Short Communication: Resolution of Tenofovir Disoproxil Fumarate Induced Fanconi Syndrome with Switch to Tenofovir Alafenamide Fumarate in a HIV-1 and Hepatitis B Coinfected Patient. AIDS Res Hum Retroviruses. 2017 Jul; 33(7):718-722. PMID: 28403627.
      View in: PubMed
    3. Karris M, Jain S, Day TR, Pérez-Santiago J, Goicoechea M, Dubé MP, Sun X, Spina C, Daar ES, Haubrich RH, Morris S. HIV viral kinetics and T cell dynamics in antiretroviral naïve persons starting an integrase strand transfer inhibitor and protease inhibitor regimen. HIV Clin Trials. 2017 03; 18(2):67-74. PMID: 28134057.
      View in: PubMed
    4. Pines HA, Wertheim JO, Liu L, Garfein RS, Little SJ, Karris M. Concurrency and HIV transmission network characteristics among MSM with recent HIV infection. AIDS. 2016 Nov 28; 30(18):2875-2883. PMID: 27662550.
      View in: PubMed
    5. Karris M, Umlauf A, Vaida F, Richman D, Little S, Smith D. A randomized controlled clinical trial on the impact of CCR5 blockade with maraviroc in early infection on T-cell dynamics. Medicine (Baltimore). 2016 Nov; 95(44):e5315. PMID: 27858912.
      View in: PubMed
    6. Karris M, Jain S, Bowman VQ, Rieg G, Goicoechea M, Dube MP, Kerkar S, Kemper C, Diamond C, Sun X, Daar ES, Haubrich RH, Morris S. Nucleoside-Sparing Regimens With Raltegravir and a Boosted Protease Inhibitor: An Unsettled Issue. J Acquir Immune Defic Syndr. 2016 06 01; 72(2):e48-50. PMID: 26977746.
      View in: PubMed
    7. Karris M, Haubrich RH. Antiretroviral therapy in the elite controller: justified or premature? J Infect Dis. 2015 Jun 01; 211(11):1689-91. PMID: 25512628.
      View in: PubMed
    8. Karris M. Pre-Exposure Prophylaxis to Prevent HIV Infection: Why Do We Need It, What Are the Limitations, and Can We Successfully Provide It Today? LGBT Health. 2014 Dec; 1(4):250-2. PMID: 26789851.
      View in: PubMed
    9. Karris M, Beekmann SE, Mehta SR, Polgreen PM. Reply to Sachdev et al. Clin Infect Dis. 2014 Jun; 58(12):1788. PMID: 24729555; PMCID: PMC4809992.
    10. Karris M, Kao YT, Patel D, Dawson M, Woods SP, Vaida F, Spina C, Richman D, Little S, Smith DM. Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. AIDS. 2014 Mar 27; 28(6):841-9. PMID: 24401640; PMCID: PMC4049563.
    11. Karris M, Beekmann SE, Mehta SR, Anderson CM, Polgreen PM. Are we prepped for preexposure prophylaxis (PrEP)? Provider opinions on the real-world use of PrEP in the United States and Canada. Clin Infect Dis. 2014 Mar; 58(5):704-12. PMID: 24319083; PMCID: PMC3922214.
    12. Pérez-Santiago J, Gianella S, Massanella M, Spina CA, Karris M, Var SR, Patel D, Jordan PS, Young JA, Little SJ, Richman DD, Smith DM. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013 Jul 31; 27(12):1921-31. PMID: 24180001; PMCID: PMC3816380.
    13. Soto PC, Karris M, Spina CA, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med (Berl). 2013 Feb; 91(2):261-70. PMID: 22945238; PMCID: PMC3558668.
    14. Karris M, Anderson CM, Morris SR, Smith DM, Little SJ. Cost savings associated with testing of antibodies, antigens, and nucleic acids for diagnosis of acute HIV infection. J Clin Microbiol. 2012 Jun; 50(6):1874-8. PMID: 22442319; PMCID: PMC3372146.
    15. Karris M, Smith DM. Tissue-specific HIV-1 infection: why it matters. Future Virol. 2011 Jul; 6(7):869-882. PMID: 23946764.
      View in: PubMed
    16. Karris M, Litwin CM, Dong HS, Vinetz J. Bartonella henselae infection of prosthetic aortic valve associated with colitis. Vector Borne Zoonotic Dis. 2011 Nov; 11(11):1503-5. PMID: 21702667; PMCID: PMC3216094.