Xia Li

Title(s)Assistant Clinical Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse awards and honors
    Tobacco-Related Disease Research Program (TRDRP) 2016  - 2018Pilot Research Award
    Tobacco-Related Disease Research Program (TRDRP) 2015  - 2018Research Project Award
    Tobacco-Related Disease Research Program (TRDRP)2011  - 2014New Investigator Award

    Collapse Research 
    Collapse research activities and funding
    Role of metabotropic glutamate receptor expression in nicotine dependence
    NIH R21DA040195Jul 1, 2015 - Jun 30, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Overview of the Biography and Legacy of Professor Athina Markou. Biol Psychiatry. 2018 06 01; 83(11):910-912. Geyer MA, Semenova S, Li X, Der-Avakian A, Barnes SA, Grant I. PMID: 29501205.
      View in: PubMed   Mentions:    Fields:    
    2. mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. Sci Rep. 2018 02 27; 8(1):3686. Li X, Peng XQ, Jordan CJ, Li J, Bi GH, He Y, Yang HJ, Zhang HY, Gardner EL, Xi ZX. PMID: 29487381; PMCID: PMC5829076.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    3. The Gamma-Aminobutyric Acid B Receptor in Depression and Reward. Biol Psychiatry. 2018 06 01; 83(11):963-976. Jacobson LH, Vlachou S, Slattery DA, Li X, Cryan JF. PMID: 29759132.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    4. Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction. Biol Psychiatry. 2018 06 01; 83(11):947-954. Cross AJ, Anthenelli R, Li X. PMID: 29301614; PMCID: PMC5953779.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    5. KK-92A, a novel GABAB receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats. Psychopharmacology (Berl). 2017 05; 234(9-10):1633-1644. Li X, Sturchler E, Kaczanowska K, Cameron M, Finn MG, Griffin P, McDonald P, Markou A. PMID: 28382542.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity. Pharmacol Res Perspect. 2017 04; 5(2):e00288. Sturchler E, Li X, de Lourdes Ladino M, Kaczanowska K, Cameron M, Griffin PR, Finn MG, Markou A, McDonald P. PMID: 28357120; PMCID: PMC5368958.
      View in: PubMed   Mentions: 9     Fields:    
    7. Cue-induced nicotine-seeking behavior after withdrawal with or without extinction in rats. Addict Biol. 2018 01; 23(1):111-119. Markou A, Li J, Tse K, Li X. PMID: 27894160; PMCID: PMC5446935.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    8. Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats. Psychopharmacology (Berl). 2016 05; 233(10):1801-14. Li X, D'Souza MS, Niño AM, Doherty J, Cross A, Markou A. PMID: 26873083.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    9. The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats. Neuropharmacology. 2015 Oct; 97:357-64. Li X, Kaczanowska K, Finn MG, Markou A, Risbrough VB. PMID: 26002628; PMCID: PMC4537349.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    10. Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence. CNS Neurol Disord Drug Targets. 2015; 14(6):738-44. Li X, Markou A. PMID: 26022263; PMCID: PMC4562387.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    11. Species differences in cannabinoid receptor 2 and receptor responses to cocaine self-administration in mice and rats. Neuropsychopharmacology. 2015 Mar; 40(4):1037-51. Zhang HY, Bi GH, Li X, Li J, Qu H, Zhang SJ, Li CY, Onaivi ES, Gardner EL, Xi ZX, Liu QR. PMID: 25374096; PMCID: PMC4330519.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    12. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E5007-15. Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J, Xi ZX. PMID: 25368177; PMCID: PMC4246322.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    13. Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation. Neuropharmacology. 2014 Jan; 76 Pt B:554-65. Li X, Semenova S, D'Souza MS, Stoker AK, Markou A. PMID: 23752091; PMCID: PMC3830589.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    14. Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. Neuropharmacology. 2013 Jul; 70:156-67. Li X, Risbrough VB, Cates-Gatto C, Kaczanowska K, Finn MG, Roberts AJ, Markou A. PMID: 23376712; PMCID: PMC3644349.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    15. Increased vulnerability to cocaine in mice lacking dopamine D3 receptors. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17675-80. Song R, Zhang HY, Li X, Bi GH, Gardner EL, Xi ZX. PMID: 23045656; PMCID: PMC3491487.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    16. Effects of metabotropic glutamate receptor ligands on male sexual behavior in rats. Neuropharmacology. 2013 Mar; 66:373-81. Li X, Higley A, Song R, Xi ZX. PMID: 22968089; PMCID: PMC3524377.
      View in: PubMed   Mentions: 4     Fields:    
    17. Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats. Addict Biol. 2013 Jul; 18(4):665-77. Xi ZX, Li X, Li J, Peng XQ, Song R, Gaál J, Gardner EL. PMID: 22913325; PMCID: PMC3509252.
      View in: PubMed   Mentions: 15     Fields:    
    18. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. 2013 Mar; 66:12-23. Li X, Xi ZX, Markou A. PMID: 22546614; PMCID: PMC3746801.
      View in: PubMed   Mentions: 11     Fields:    
    19. Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice. Nat Neurosci. 2011 Jul 24; 14(9):1160-6. Xi ZX, Peng XQ, Li X, Song R, Zhang HY, Liu QR, Yang HJ, Bi GH, Li J, Gardner EL. PMID: 21785434; PMCID: PMC3164946.
      View in: PubMed   Mentions: 166     Fields:    
    20. YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. Addict Biol. 2012 Mar; 17(2):259-73. Song R, Yang RF, Wu N, Su RB, Li J, Peng XQ, Li X, Gaál J, Xi ZX, Gardner EL. PMID: 21507153; PMCID: PMC5531447.
      View in: PubMed   Mentions: 37     Fields:    
    21. Dopamine D(3) receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. Eur J Pharmacol. 2011 Jun 01; 659(2-3):187-92. Higley AE, Kiefer SW, Li X, Gaál J, Xi ZX, Gardner EL. PMID: 21466803; PMCID: PMC3728376.
      View in: PubMed   Mentions: 30     Fields:    
    22. Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications. Neuropsychopharmacology. 2010 Dec; 35(13):2564-78. Peng XQ, Xi ZX, Li X, Spiller K, Li J, Chun L, Wu KM, Froimowitz M, Gardner EL. PMID: 20827272; PMCID: PMC2978747.
      View in: PubMed   Mentions: 7     Fields:    
    23. Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. J Neurochem. 2010 Sep 01; 114(5):1368-80. Li X, Li J, Gardner EL, Xi ZX. PMID: 20534005; PMCID: PMC2923231.
      View in: PubMed   Mentions: 24     Fields:    
    24. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. J Neurochem. 2010 Jan; 112(2):564-76. Xi ZX, Li X, Peng XQ, Li J, Chun L, Gardner EL, Thomas AG, Slusher BS, Ashby CR. PMID: 19895667; PMCID: PMC2809121.
      View in: PubMed   Mentions: 21     Fields:    
    25. N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. Neuropharmacology. 2010 Jan; 58(1):304-13. Xi ZX, Kiyatkin M, Li X, Peng XQ, Wiggins A, Spiller K, Li J, Gardner EL. PMID: 19559037; PMCID: PMC2783331.
      View in: PubMed   Mentions: 18     Fields:    
    26. Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in rats. Neuropharmacology. 2009 Jul; 57(1):60-6. Spiller K, Xi ZX, Li X, Ashby CR, Callahan PM, Tehim A, Gardner EL. PMID: 19393252; PMCID: PMC2746646.
      View in: PubMed   Mentions: 25     Fields:    
    27. A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats. Neuroscience. 2009 Jun 30; 161(2):392-402. Xi ZX, Kleitz HK, Deng X, Ladenheim B, Peng XQ, Li X, Gardner EL, Stein EA, Cadet JL. PMID: 19336247; PMCID: PMC3737775.
      View in: PubMed   Mentions: 20     Fields:    
    28. The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. Neuropharmacology. 2009 Mar; 56(4):752-60. Peng XQ, Ashby CR, Spiller K, Li X, Li J, Thomasson N, Millan MJ, Mocaër E, Munoz C, Gardner EL, Xi ZX. PMID: 19136017; PMCID: PMC3726045.
      View in: PubMed   Mentions: 19     Fields:    
    29. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology. 2009 Jun; 34(7):1783-96. Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX. PMID: 19158667; PMCID: PMC3739975.
      View in: PubMed   Mentions: 29     Fields:    
    30. Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice. Psychopharmacology (Berl). 2009 May; 204(1):1-11. Li X, Hoffman AF, Peng XQ, Lupica CR, Gardner EL, Xi ZX. PMID: 19099297; PMCID: PMC3729960.
      View in: PubMed   Mentions: 19     Fields:    
    31. Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism. Drug Alcohol Depend. 2008 Oct 01; 97(3):216-25. Peng XQ, Li X, Gilbert JG, Pak AC, Ashby CR, Brodie JD, Dewey SL, Gardner EL, Xi ZX. PMID: 18063319; PMCID: PMC2574671.
      View in: PubMed   Mentions: 6     Fields:    
    32. Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Drug Alcohol Depend. 2008 Oct 01; 97(3):207-15. Peng XQ, Li X, Li J, Ramachandran PV, Gagare PD, Pratihar D, Ashby CR, Gardner EL, Xi ZX. PMID: 18065162; PMCID: PMC2574799.
      View in: PubMed   Mentions: 9     Fields:    
    33. The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats. Neuropharmacology. 2008 Mar; 54(3):542-51. Li X, Gardner EL, Xi ZX. PMID: 18155073; PMCID: PMC2410088.
      View in: PubMed   Mentions: 14     Fields:    
    34. Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology. 2008 Jun; 33(7):1735-45. Xi ZX, Spiller K, Pak AC, Gilbert J, Dillon C, Li X, Peng XQ, Gardner EL. PMID: 17728698.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    35. Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology. 2007 Nov; 53(6):771-82. Xi ZX, Yang Z, Li SJ, Li X, Dillon C, Peng XQ, Spiller K, Gardner EL. PMID: 17888459; PMCID: PMC2965413.
      View in: PubMed   Mentions: 20     Fields:    
    36. Novel mutations found in mitochondrial diabetes in Chinese Han population. Diabetes Res Clin Pract. 2007 Jun; 76(3):425-35. Liu SM, Zhou X, Zheng F, Li X, Liu F, Zhang HM, Xie Y. PMID: 17125872.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    37. [Development of a DNA chip screening mitochondrial DNA mutations in patients with diabetes mellitus]. Zhonghua Yi Xue Za Zhi. 2006 Oct 31; 86(40):2853-7. Liu SM, Zhou X, Zheng F, Li X, Qin H, Zhang HM, Li D. PMID: 17200023.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci. 2006 Aug 16; 26(33):8531-6. Xi ZX, Gilbert JG, Peng XQ, Pak AC, Li X, Gardner EL. PMID: 16914679; PMCID: PMC6674340.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    39. Variation of mitochondrial gene and the association with type 2 diabetes mellitus in a Chinese population. Diabetes Res Clin Pract. 2006 Jul; 73(1):77-82. Tang DL, Zhou X, Li X, Zhao L, Liu F. PMID: 16414144.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    40. [Association of mitochondrial DNA variation with type 2 diabetes mellitus]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Dec; 22(6):636-40. Tang DL, Zhou X, Zhou KY, Li X, Zhao L, Liu F, Zheng F, Liu SM. PMID: 16331560.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. The clinical evaluation for the mitochondrial DNA detected from hair follicles. Clin Chim Acta. 2005 Nov; 361(1-2):214-6. Li X, Zhou X, Li J, Guo QL, Zheng F, Lu MX, Segbo J, Peng JH, Yan SK. PMID: 16023631.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    42. Synthesis of beta-substituted cationic porphyrins and their interactions with DNA. Bioorg Med Chem Lett. 2003 Nov 03; 13(21):3731-3. Chen B, Qin W, Wang P, Tian T, Ma H, Cao X, Wu X, Zhou X, Zhang XL, Liu F, Zheng F, Li X. PMID: 14552768.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    43. [A primary investigation on disseminated histoplasmosis in Hubei]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Aug; 24(8):708-10. Li X, Li J, Feng GQ, Gui XE, Zeng XC. PMID: 14521794.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
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