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Xia Li

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #0851
La Jolla CA 92093
Phone858-534-1503
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    Collapse Biography 
    Collapse Awards and Honors
    Tobacco-Related Disease Research Program (TRDRP) 2016  - 2018Pilot Research Award
    Tobacco-Related Disease Research Program (TRDRP) 2015  - 2018Research Project Award
    Tobacco-Related Disease Research Program (TRDRP)2011  - 2014New Investigator Award

    Collapse Research 
    Collapse Research Activities and Funding
    Role of metabotropic glutamate receptor expression in nicotine dependence
    NIH R21DA040195Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li X, Peng XQ, Jordan CJ, Li J, Bi GH, He Y, Yang HJ, Zhang HY, Gardner EL, Xi ZX. mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. Sci Rep. 2018 Feb 27; 8(1):3686. PMID: 29487381.
      View in: PubMed
    2. Li X, Sturchler E, Kaczanowska K, Cameron M, Finn MG, Griffin P, McDonald P, Markou A. KK-92A, a novel GABAB receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats. Psychopharmacology (Berl). 2017 May; 234(9-10):1633-1644. PMID: 28382542.
      View in: PubMed
    3. Sturchler E, Li X, de Lourdes Ladino M, Kaczanowska K, Cameron M, Griffin PR, Finn MG, Markou A, McDonald P. GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity. Pharmacol Res Perspect. 2017 Apr; 5(2):e00288. PMID: 28357120.
      View in: PubMed
    4. Markou A, Li J, Tse K, Li X. Cue-induced nicotine-seeking behavior after withdrawal with or without extinction in rats. Addict Biol. 2018 Jan; 23(1):111-119. PMID: 27894160.
      View in: PubMed
    5. Li X, D'Souza MS, Niño AM, Doherty J, Cross A, Markou A. Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats. Psychopharmacology (Berl). 2016 05; 233(10):1801-14. PMID: 26873083.
      View in: PubMed
    6. Li X, Kaczanowska K, Finn MG, Markou A, Risbrough VB. The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats. Neuropharmacology. 2015 Oct; 97:357-64. PMID: 26002628; PMCID: PMC4537349 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    7. Li X, Markou A. Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence. CNS Neurol Disord Drug Targets. 2015; 14(6):738-44. PMID: 26022263; PMCID: PMC4562387.
      View in: PubMed, PubMed Central
    8. Zhang HY, Bi GH, Li X, Li J, Qu H, Zhang SJ, Li CY, Onaivi ES, Gardner EL, Xi ZX, Liu QR. Species differences in cannabinoid receptor 2 and receptor responses to cocaine self-administration in mice and rats. Neuropsychopharmacology. 2015 Mar; 40(4):1037-51. PMID: 25374096; PMCID: PMC4330519.
      View in: PubMed, PubMed Central
    9. Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J, Xi ZX. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E5007-15. PMID: 25368177; PMCID: PMC4246322.
      View in: PubMed, PubMed Central
    10. Li X, Semenova S, D'Souza MS, Stoker AK, Markou A. Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation. Neuropharmacology. 2014 Jan; 76 Pt B:554-65. PMID: 23752091; PMCID: PMC3830589.
      View in: PubMed, PubMed Central
    11. Li X, Risbrough VB, Cates-Gatto C, Kaczanowska K, Finn MG, Roberts AJ, Markou A. Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. Neuropharmacology. 2013 Jul; 70:156-67. PMID: 23376712; PMCID: PMC3644349.
      View in: PubMed, PubMed Central
    12. Song R, Zhang HY, Li X, Bi GH, Gardner EL, Xi ZX. Increased vulnerability to cocaine in mice lacking dopamine D3 receptors. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17675-80. PMID: 23045656; PMCID: PMC3491487.
      View in: PubMed, PubMed Central
    13. Li X, Higley A, Song R, Xi ZX. Effects of metabotropic glutamate receptor ligands on male sexual behavior in rats. Neuropharmacology. 2013 Mar; 66:373-81. PMID: 22968089.
      View in: PubMed
    14. Xi ZX, Li X, Li J, Peng XQ, Song R, Gaál J, Gardner EL. Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats. Addict Biol. 2013 Jul; 18(4):665-77. PMID: 22913325.
      View in: PubMed
    15. Li X, Xi ZX, Markou A. Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology. 2013 Mar; 66:12-23. PMID: 22546614.
      View in: PubMed
    16. Cammarato A, Li X, Reedy MC, Lee CF, Lehman W, Bernstein SI. Structural basis for myopathic defects engendered by alterations in the myosin rod. J Mol Biol. 2011 Dec 09; 414(4):477-84. PMID: 22037585; PMCID: PMC3230674.
      View in: PubMed, PubMed Central
    17. Xi ZX, Peng XQ, Li X, Song R, Zhang HY, Liu QR, Yang HJ, Bi GH, Li J, Gardner EL. Brain cannabinoid CB2 receptors modulate cocaine's actions in mice. Nat Neurosci. 2011 Jul 24; 14(9):1160-6. PMID: 21785434.
      View in: PubMed
    18. Song R, Yang RF, Wu N, Su RB, Li J, Peng XQ, Li X, Gaál J, Xi ZX, Gardner EL. YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. Addict Biol. 2012 Mar; 17(2):259-73. PMID: 21507153.
      View in: PubMed
    19. Higley AE, Kiefer SW, Li X, Gaál J, Xi ZX, Gardner EL. Dopamine D(3) receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. Eur J Pharmacol. 2011 Jun 01; 659(2-3):187-92. PMID: 21466803.
      View in: PubMed
    20. Peng XQ, Xi ZX, Li X, Spiller K, Li J, Chun L, Wu KM, Froimowitz M, Gardner EL. Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications. Neuropsychopharmacology. 2010 Dec; 35(13):2564-78. PMID: 20827272.
      View in: PubMed
    21. Li X, Li J, Gardner EL, Xi ZX. Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. J Neurochem. 2010 Sep 01; 114(5):1368-80. PMID: 20534005.
      View in: PubMed
    22. Xi ZX, Li X, Peng XQ, Li J, Chun L, Gardner EL, Thomas AG, Slusher BS, Ashby CR. Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. J Neurochem. 2010 Jan; 112(2):564-76. PMID: 19895667.
      View in: PubMed
    23. Xi ZX, Kiyatkin M, Li X, Peng XQ, Wiggins A, Spiller K, Li J, Gardner EL. N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. Neuropharmacology. 2010 Jan; 58(1):304-13. PMID: 19559037.
      View in: PubMed
    24. Spiller K, Xi ZX, Li X, Ashby CR, Callahan PM, Tehim A, Gardner EL. Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in rats. Neuropharmacology. 2009 Jul; 57(1):60-6. PMID: 19393252.
      View in: PubMed
    25. Xi ZX, Kleitz HK, Deng X, Ladenheim B, Peng XQ, Li X, Gardner EL, Stein EA, Cadet JL. A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats. Neuroscience. 2009 Jun 30; 161(2):392-402. PMID: 19336247.
      View in: PubMed
    26. Peng XQ, Ashby CR, Spiller K, Li X, Li J, Thomasson N, Millan MJ, Mocaër E, Munoz C, Gardner EL, Xi ZX. The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. Neuropharmacology. 2009 Mar; 56(4):752-60. PMID: 19136017.
      View in: PubMed
    27. Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology. 2009 Jun; 34(7):1783-96. PMID: 19158667.
      View in: PubMed
    28. Li X, Hoffman AF, Peng XQ, Lupica CR, Gardner EL, Xi ZX. Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice. Psychopharmacology (Berl). 2009 May; 204(1):1-11. PMID: 19099297.
      View in: PubMed
    29. Peng XQ, Li X, Gilbert JG, Pak AC, Ashby CR, Brodie JD, Dewey SL, Gardner EL, Xi ZX. Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism. Drug Alcohol Depend. 2008 Oct 01; 97(3):216-25. PMID: 18063319.
      View in: PubMed
    30. Peng XQ, Li X, Li J, Ramachandran PV, Gagare PD, Pratihar D, Ashby CR, Gardner EL, Xi ZX. Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Drug Alcohol Depend. 2008 Oct 01; 97(3):207-15. PMID: 18065162.
      View in: PubMed
    31. Li X, Gardner EL, Xi ZX. The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats. Neuropharmacology. 2008 Mar; 54(3):542-51. PMID: 18155073.
      View in: PubMed
    32. Xi ZX, Spiller K, Pak AC, Gilbert J, Dillon C, Li X, Peng XQ, Gardner EL. Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology. 2008 Jun; 33(7):1735-45. PMID: 17728698.
      View in: PubMed
    33. Xi ZX, Yang Z, Li SJ, Li X, Dillon C, Peng XQ, Spiller K, Gardner EL. Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology. 2007 Nov; 53(6):771-82. PMID: 17888459.
      View in: PubMed
    34. Liu SM, Zhou X, Zheng F, Li X, Liu F, Zhang HM, Xie Y. Novel mutations found in mitochondrial diabetes in Chinese Han population. Diabetes Res Clin Pract. 2007 Jun; 76(3):425-35. PMID: 17125872.
      View in: PubMed
    35. Liu SM, Zhou X, Zheng F, Li X, Qin H, Zhang HM, Li D. [Development of a DNA chip screening mitochondrial DNA mutations in patients with diabetes mellitus]. Zhonghua Yi Xue Za Zhi. 2006 Oct 31; 86(40):2853-7. PMID: 17200023.
      View in: PubMed
    36. Xi ZX, Gilbert JG, Peng XQ, Pak AC, Li X, Gardner EL. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci. 2006 Aug 16; 26(33):8531-6. PMID: 16914679.
      View in: PubMed
    37. Tang DL, Zhou X, Li X, Zhao L, Liu F. Variation of mitochondrial gene and the association with type 2 diabetes mellitus in a Chinese population. Diabetes Res Clin Pract. 2006 Jul; 73(1):77-82. PMID: 16414144.
      View in: PubMed
    38. Tang DL, Zhou X, Zhou KY, Li X, Zhao L, Liu F, Zheng F, Liu SM. [Association of mitochondrial DNA variation with type 2 diabetes mellitus]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Dec; 22(6):636-40. PMID: 16331560.
      View in: PubMed
    39. Li X, Zhou X, Li J, Guo QL, Zheng F, Lu MX, Segbo J, Peng JH, Yan SK. The clinical evaluation for the mitochondrial DNA detected from hair follicles. Clin Chim Acta. 2005 Nov; 361(1-2):214-6. PMID: 16023631.
      View in: PubMed
    40. Chen B, Qin W, Wang P, Tian T, Ma H, Cao X, Wu X, Zhou X, Zhang XL, Liu F, Zheng F, Li X. Synthesis of beta-substituted cationic porphyrins and their interactions with DNA. Bioorg Med Chem Lett. 2003 Nov 03; 13(21):3731-3. PMID: 14552768.
      View in: PubMed
    41. Li X, Li J, Feng GQ, Gui XE, Zeng XC. [A primary investigation on disseminated histoplasmosis in Hubei]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Aug; 24(8):708-10. PMID: 14521794.
      View in: PubMed
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