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Douglas Richman

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0679
La Jolla CA 92093
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    Martin Delaney Collaboratory to Eradicate HIV-1 Infection
    NIH U19AI096113Jul 8, 2011 - Jun 30, 2016
    Role: Co-Investigator
    Gene expression biomarkers of immune recovery in HIV infected patients
    NIH/NIAID R01AI087164Dec 15, 2009 - Nov 30, 2014
    Role: Principal Investigator
    Targeting regulators of cellular gene transcription to impact HIV latency
    NIH/NIAID P01AI080193Jun 5, 2009 - Dec 31, 2011
    Role: Principal Investigator
    Determinants of HIV Transmission
    NIH/NIAID P01AI074621Mar 15, 2008 - Feb 28, 2014
    Role: Co-Investigator
    Meeting Support for HIV Dynamics and Evolution
    NIH/NIAID R13AI056338Apr 1, 2003 - Jul 31, 2011
    Role: Principal Investigator
    9th Annual International Mtg on HIV Dynamics &Evolution
    NIH/NIAID R13AI051989Mar 16, 2002 - Mar 15, 2003
    Role: Principal Investigator
    BIOMATHEMATICAL ANALYSIS OF VIRAL DYNAMICS AND EVOLUTION
    NIH/NIAID R01AI047745Jul 1, 2000 - Dec 31, 2011
    Role: Principal Investigator
    BIOMATHEMATICAL ANALYSIS OF VIRAL DYNAMICS AND EVOLUTION
    NIH/NIAID R21AI047745Jul 1, 2000 - Jun 30, 2001
    Role: Principal Investigator
    Southern California Primary Infection Program
    NIH/NIAID U01AI043638Aug 1, 1998 - Jun 30, 2011
    Role: Principal Investigator
    RESISTANCE TO ANTIVIRALS IN HIV INFECTED PATIENTS
    NIH/FIC R03TW000767Sep 30, 1996 - Feb 28, 2003
    Role: Principal Investigator
    ANTIVIRAL RESISTANCE IN AIDS
    NIH/FIC R03TW000680Sep 1, 1996 - Aug 31, 1999
    Role: Principal Investigator
    Center for AIDS Research
    NIH/NIAID P30AI036214Apr 1, 1994 - Mar 31, 2023
    Role: Principal Investigator
    AIDS Training Grant
    NIH/NIAID T32AI007384Aug 1, 1990 - Aug 31, 2021
    Role: Principal Investigator
    RAPID MICROBIAL DIAGNOSIS BY NUCLEIC ACID AMPLIFICATION
    NIH/NIAID U01AI030457Jul 1, 1990 - Jun 30, 1996
    Role: Principal Investigator
    ANTIVIRAL RESISTANCE IN AIDS
    NIH/NIAID R37AI029164Sep 30, 1989 - Jun 30, 2006
    Role: Principal Investigator
    MECHANISMS OF RESISTANCE IN CLINICAL ISOLATES OF HIV
    NIH/NIAID R01AI029164Sep 30, 1989 - Jul 31, 1994
    Role: Principal Investigator
    DEVELOPMENT OF SCREENING TESTS FOR HTLV-III
    NIH/NHLBI N01HB067019Sep 30, 1986 - Jun 1, 1992
    Role: Principal Investigator
    SAN DIEGO AIDS CLINICAL TRIAL UNIT
    NIH/NIAID U01AI027670Jun 30, 1986 - Dec 31, 2006
    Role: Principal Investigator
    NUCLEIC ACID HYBRIDIZATION TO DETECT AIDS RELATED AGENTS
    NIH/NHLBI R01HL032471Apr 1, 1984 - Mar 31, 1988
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rothenberger M, Wagner JE, Haase A, Richman D, Grzywacz B, Strain M, Lada S, Estes J, Fletcher CV, Podany AT, Anderson J, Schmidt T, Wietgrefe S, Schacker T, Verneris MR. Transplantation of CCR5?32 Homozygous Umbilical Cord Blood in a Child With Acute Lymphoblastic Leukemia and Perinatally Acquired HIV Infection. Open Forum Infect Dis. 2018 May; 5(5):ofy090. PMID: 29868623.
      View in: PubMed
    2. Abdel-Mohsen M, Kuri-Cervantes L, Grau-Exposito J, Spivak AM, Nell RA, Tomescu C, Vadrevu SK, Giron LB, Serra-Peinado C, Genescà M, Castellví J, Wu G, Del Rio Estrada PM, González-Navarro M, Lynn K, King CT, Vemula S, Cox K, Wan Y, Li Q, Mounzer K, Kostman J, Frank I, Paiardini M, Hazuda D, Reyes-Terán G, Richman D, Howell B, Tebas P, Martinez-Picado J, Planelles V, Buzon MJ, Betts MR, Montaner LJ. CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells. Sci Transl Med. 2018 Apr 18; 10(437). PMID: 29669853.
      View in: PubMed
    3. White CH, Beliakova-Bethell N, Lada SM, Breen MS, Hurst TP, Spina CA, Richman D, Frater J, Magiorkinis G, Woelk CH. Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment. Front Immunol. 2018; 9:603. PMID: 29706951.
      View in: PubMed
    4. Sadanand S, Das J, Chung AW, Schoen MK, Lane S, Suscovich TJ, Streeck H, Smith DM, Little SJ, Lauffenburger DA, Richman D, Alter G. Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors. AIDS. 2018 Feb 20; 32(4):443-450. PMID: 29239894.
      View in: PubMed
    5. Ruggiero A, Cozzi-Lepri A, Beloukas A, Richman D, Khoo S, Phillips A, Geretti AM. Factors Associated With Persistence of Plasma HIV-1 RNA During Long-term Continuously Suppressive Firstline Antiretroviral Therapy. Open Forum Infect Dis. 2018 Feb; 5(2):ofy032. PMID: 29507867.
      View in: PubMed
    6. Chaillon A, Gianella S, Lada SM, Perez-Santiago J, Jordan P, Ignacio C, Karris M, Richman D, Mehta SR, Little SJ, Wertheim JO, Smith DM. Size, Composition, and Evolution of HIV DNA Populations during Early Antiretroviral Therapy and Intensification with Maraviroc. J Virol. 2018 Feb 01; 92(3). PMID: 29142136.
      View in: PubMed
    7. Wensing AM, Calvez V, Günthard HF, Johnson VA, Paredes R, Pillay D, Shafer RW, Richman D. 2017 Update of the Drug Resistance Mutations in HIV-1. Top Antivir Med. 2017 Dec/Jan; 24(4):132-133. PMID: 28208121.
      View in: PubMed
    8. Benson CA, Currier JS, Del Rio C, Gallant JE, Gulick RM, Marrazzo JM, Richman D, Saag MS, Schooley RT, Volberding PA. A Conversation Among the IAS-USA Board of Directors: Hot Topics and Emerging Data in HIV Research and Care. Top Antivir Med. 2017 Dec/Jan; 24(4):142-151. PMID: 28208122.
      View in: PubMed
    9. Cummins NW, Rizza S, Litzow MR, Hua S, Lee GQ, Einkauf K, Chun TW, Rhame F, Baker JV, Busch MP, Chomont N, Dean PG, Fromentin R, Haase AT, Hampton D, Keating SM, Lada SM, Lee TH, Natesampillai S, Richman D, Schacker TW, Wietgrefe S, Yu XG, Yao JD, Zeuli J, Lichterfeld M, Badley AD. Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study. PLoS Med. 2017 Nov; 14(11):e1002461. PMID: 29182633.
      View in: PubMed
    10. Hermans LE, Moorhouse M, Carmona S, Grobbee DE, Hofstra LM, Richman D, Tempelman HA, Venter WDF, Wensing AMJ. Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: a multicentre cohort study. Lancet Infect Dis. 2018 Feb; 18(2):188-197. PMID: 29158101.
      View in: PubMed
    11. Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman D, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS Med. 2017 Nov; 14(11):e1002417. PMID: 29112956.
      View in: PubMed
    12. Richman D, Gallo RC. Mark Wainberg. Curr Opin HIV AIDS. 2017 Sep; 12(5):423-424. PMID: 28771448.
      View in: PubMed
    13. Wagner GA, Landais E, Caballero G, Phung P, Kosakovsky Pond SL, Poignard P, Richman D, Little SJ, Smith DM. Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response. J Virol. 2017 09 01; 91(17). PMID: 28615205.
      View in: PubMed
    14. Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman D, Spina CA. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 08; 508:127-133. PMID: 28527342.
      View in: PubMed
    15. Yek C, Massanella M, Peling T, Lednovich K, Nair SV, Worlock A, Vargas M, Gianella S, Ellis RJ, Strain MC, Busch MP, Nugent CT, Richman D. Evaluation of the Aptima HIV-1 Quant Dx Assay for HIV-1 RNA Quantitation in Different Biological Specimen Types. J Clin Microbiol. 2017 Aug; 55(8):2544-2553. PMID: 28592548.
      View in: PubMed
    16. Vesa J, Chaillon A, Wagner GA, Anderson CM, Richman D, Smith DM, Little SJ. Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles. AIDS. 2017 May 15; 31(8):1149-1158. PMID: 28244954.
      View in: PubMed
    17. Choi JY, Pond SLK, Anderson CM, Richman D, Smith DM. Molecular Features of the V1-V4 Coding Region of Sexually Transmitted Human Immunodeficiency Virus Type 1. J Infect Dis. 2017 May 15; 215(10):1506-1513. PMID: 28419276.
      View in: PubMed
    18. Honeycutt JB, Thayer WO, Baker CE, Ribeiro RM, Lada SM, Cao Y, Cleary RA, Hudgens MG, Richman D, Garcia JV. HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy. Nat Med. 2017 May; 23(5):638-643. PMID: 28414330.
      View in: PubMed
    19. Richman D. HIV: Finding latent needles in a haystack. Nature. 2017 03 23; 543(7646):499-500. PMID: 28297707.
      View in: PubMed
    20. White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina CA, Margolis DM, Richman D, Planelles V, Bosque A, Woelk CH. Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. PLoS Pathog. 2016 Nov; 12(11):e1006026. PMID: 27898737.
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    21. Wagner GA, Chaillon A, Liu S, Franklin DR, Caballero G, Kosakovsky Pond SL, Vaida F, Heaton RK, Letendre SL, Grant I, Richman D, Smith DM. HIV-associated neurocognitive disorder is associated with HIV-1 dual infection. AIDS. 2016 Nov 13; 30(17):2591-2597. PMID: 27536983.
      View in: PubMed
    22. Karris MY, Umlauf A, Vaida F, Richman D, Little S, Smith D. A randomized controlled clinical trial on the impact of CCR5 blockade with maraviroc in early infection on T-cell dynamics. Medicine (Baltimore). 2016 Nov; 95(44):e5315. PMID: 27858912.
      View in: PubMed
    23. Bruner KM, Murray AJ, Pollack RA, Soliman MG, Laskey SB, Capoferri AA, Lai J, Strain MC, Lada SM, Hoh R, Ho YC, Richman D, Deeks SG, Siliciano JD, Siliciano RF. Defective proviruses rapidly accumulate during acute HIV-1 infection. Nat Med. 2016 09; 22(9):1043-9. PMID: 27500724; PMCID: PMC5014606 [Available on 03/01/17].
    24. Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman D, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD. Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy. PLoS One. 2016; 11(8):e0160192. PMID: 27483366; PMCID: PMC4970722.
    25. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. PMID: 27400264.
      View in: PubMed
    26. Laird Smith M, Murrell B, Eren K, Ignacio C, Landais E, Weaver S, Phung P, Ludka C, Hepler L, Caballero G, Pollner T, Guo Y, Richman D. Rapid Sequencing of Complete env Genes from Primary HIV-1 Samples. Virus Evol. 2016 Jul; 2(2):vew018. PMID: 29492273.
      View in: PubMed
    27. Mehta SR, Murrell B, Anderson CM, Kosakovsky Pond SL, Wertheim JO, Young JA, Freitas L, Richman D, Mathews WC, Scheffler K, Little SJ, Smith DM. Using HIV Sequence and Epidemiologic Data to Assess the Effect of Self-referral Testing for Acute HIV Infection on Incident Diagnoses in San Diego, California. Clin Infect Dis. 2016 Jul 01; 63(1):101-107. PMID: 27174704; PMCID: PMC4901863 [Available on 07/01/17].
    28. Gianella S, Anderson CM, Var SR, Oliveira MF, Lada SM, Vargas MV, Massanella M, Little SJ, Richman D, Strain MC, Pérez-Santiago J, Smith DM. Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection. J Virol. 2016 Apr; 90(8):3944-3952. PMID: 26842469.
      View in: PubMed
    29. Richman D. Editorial Commentary: HIV Is Putting Up Less Resistance. Clin Infect Dis. 2016 05 15; 62(10):1318-9. PMID: 26962077.
      View in: PubMed
    30. Massanella M, Richman D. Measuring the latent reservoir in vivo. J Clin Invest. 2016 Feb; 126(2):464-72. PMID: 26829625; PMCID: PMC4731179 [Available on 02/01/17].
    31. Panichsillapakit T, Smith DM, Wertheim JO, Richman D, Little SJ, Mehta SR. Prevalence of Transmitted HIV Drug Resistance Among Recently Infected Persons in San Diego, CA 1996-2013. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):228-36. PMID: 26413846; PMCID: PMC4712087 [Available on 02/01/17].
    32. Panichsillapakit T, Patel D, Santangelo J, Richman D, Little SJ, Smith DM. Colorectal Disorders in Acute Human Immunodeficiency Virus Infection: A Case Series. Open Forum Infect Dis. 2016 Jan; 3(1):ofw014. PMID: 26925432; PMCID: PMC4766383.
    33. Rhee SY, Jordan MR, Raizes E, Chua A, Parkin N, Kantor R, Van Zyl GU, Mukui I, Hosseinipour MC, Frenkel LM, Ndembi N, Hamers RL, Rinke de Wit TF, Wallis CL, Gupta RK, Fokam J, Zeh C, Schapiro JM, Carmona S, Katzenstein D, Tang M, Aghokeng AF, De Oliveira T, Wensing AM, Gallant JE, Wainberg MA, Richman D, Fitzgibbon JE, Schito M, Bertagnolio S, Yang C, Shafer RW. HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing. PLoS One. 2015; 10(12):e0145772. PMID: 26717411.
      View in: PubMed
    34. Richman D. HIV: Cure by killing. Nature. 2015 Dec 10; 528(7581):198-9. PMID: 26633623.
      View in: PubMed
    35. Gianella S, Anderson CM, Richman D, Smith DM, Little SJ. No evidence of posttreatment control after early initiation of antiretroviral therapy. AIDS. 2015 Oct 23; 29(16):2093-7. PMID: 26544575; PMCID: PMC4638137 [Available on 10/23/16].
    36. Wensing AM, Calvez V, Günthard HF, Johnson VA, Paredes R, Pillay D, Shafer RW, Richman D. 2015 Update of the Drug Resistance Mutations in HIV-1. Top Antivir Med. 2015 Oct-Nov; 23(4):132-41. PMID: 26713503.
      View in: PubMed
    37. White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman D, Spina CA, Garbis SD, Woelk CH, Beliakova-Bethell N. Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Res. 2015 Nov; 123:78-85. PMID: 26343910.
      View in: PubMed
    38. Massanella M, Gianella S, Schrier R, Dan JM, Pérez-Santiago J, Oliveira MF, Richman D, Little SJ, Benson CA, Daar ES, Dube MP, Haubrich RH, Smith DM, Morris SR. Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy. Sci Rep. 2015 Aug 24; 5:13179. PMID: 26299251; PMCID: PMC4547398.
    39. Ruggiero A, De Spiegelaere W, Cozzi-Lepri A, Kiselinova M, Pollakis G, Beloukas A, Vandekerckhove L, Strain M, Richman D, Phillips A, Geretti AM. During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ. EBioMedicine. 2015 Sep; 2(9):1153-9. PMID: 26498496; PMCID: PMC4588402.
    40. Rokx C, Richman D, Müller-Trutwin M, Silvestri G, Lunzen J, Khoo S, Lichterfeld M, Altfeld M, Perno CF, Hunt PW, Mallon P, Rockstroh JK, Pozniak AL, Clotet B, Boucher CA. Second European Round Table on the Future Management of HIV: 10-11 October 2014, Barcelona, Spain. J Virus Erad. 2015 Jul 01; 1(3):211-20. PMID: 27482415; PMCID: PMC4946744.
    41. Procopio FA, Fromentin R, Kulpa DA, Brehm JH, Bebin AG, Strain MC, Richman D, O'Doherty U, Palmer S, Hecht FM, Hoh R, Barnard RJ, Miller MD, Hazuda DJ, Deeks SG, Sékaly RP, Chomont N. A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals. EBioMedicine. 2015 Aug; 2(8):874-83. PMID: 26425694.
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    42. Massanella M, Gianella S, Lada SM, Richman D, Strain MC. Quantification of Total and 2-LTR (Long terminal repeat) HIV DNA, HIV RNA and Herpesvirus DNA in PBMCs. Bio Protoc. 2015 Jun 05; 5(11). PMID: 27478862.
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    43. Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerham LR, Pilcher CD, Hecht FM, Liegler T, Richman D, Deeks SG, Pillai SK. Select host restriction factors are associated with HIV persistence during antiretroviral therapy. AIDS. 2015 Feb 20; 29(4):411-20. PMID: 25602681; PMCID: PMC4385712.
    44. Okulicz JF, Le TD, Agan BK, Camargo JF, Landrum ML, Wright E, Dolan MJ, Ganesan A, Ferguson TM, Smith DM, Richman D, Little SJ, Clark RA, He W, Ahuja SK. Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals. JAMA Intern Med. 2015 Jan; 175(1):88-99. PMID: 25419650; PMCID: PMC4286496.
    45. Torbett BE, Goodsell DS, Richman D. Preface. Curr Top Microbiol Immunol. 2015; 389:v-vii. PMID: 26086053.
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    46. Massanella M, Ouchi D, Marfil S, Llibre JM, Puertas MC, Buzón MJ, Richman D, Orna E, Stevenson M, Gatell JM, Domingo P, Negredo E, Martinez-Picado J, Clotet B, Blanco J. Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals. PLoS One. 2014; 9(12):e114142. PMID: 25462535; PMCID: PMC4252101.
    47. Persaud D, Patel K, Karalius B, Rainwater-Lovett K, Ziemniak C, Ellis A, Chen YH, Richman D, Siberry GK, Van Dyke RB, Burchett S, Seage GR, Luzuriaga K. Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents. JAMA Pediatr. 2014 Dec; 168(12):1138-46. PMID: 25286283; PMCID: PMC4324476.
    48. Carter CC, Wagner GA, Hightower GK, Caballero G, Phung P, Richman D, Pond SL, Smith DM. HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing. Virology. 2015 Jan 01; 474:34-40. PMID: 25463602; PMCID: PMC4259848.
    49. Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman D, Deeks SG. CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One. 2014; 9(10):e110731. PMID: 25340755; PMCID: PMC4207702.
    50. Hepler NL, Scheffler K, Weaver S, Murrell B, Richman D, Burton DR, Poignard P, Smith DM, Kosakovsky Pond SL. IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform. PLoS Comput Biol. 2014 Sep; 10(9):e1003842. PMID: 25254639; PMCID: PMC4177671.
    51. Menéndez-Arias L, Richman D. Editorial overview: antivirals and resistance: advances and challenges ahead. Curr Opin Virol. 2014 Oct; 8:iv-vii. PMID: 25155454.
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    52. Richman D. Joep MA Lange. Antivir Ther. 2014; 19(4):325-6. PMID: 25118622.
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    53. Kim EY, Lorenzo-Redondo R, Little SJ, Chung YS, Phalora PK, Maljkovic Berry I, Archer J, Penugonda S, Fischer W, Richman D, Bhattacharya T, Malim MH, Wolinsky SM. Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection. PLoS Pathog. 2014 Jul; 10(7):e1004281. PMID: 25080100; PMCID: PMC4117599.
    54. Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman D, Deeks SG, Pillai SK. Decreased HIV type 1 transcription in CCR5-?32 heterozygotes during suppressive antiretroviral therapy. J Infect Dis. 2014 Dec 01; 210(11):1838-43. PMID: 24935955; PMCID: PMC4271057.
    55. Wensing AM, Calvez V, Günthard HF, Johnson VA, Paredes R, Pillay D, Shafer RW, Richman D. 2014 Update of the drug resistance mutations in HIV-1. Top Antivir Med. 2014 Jun-Jul; 22(3):642-50. PMID: 25101529.
      View in: PubMed
    56. Luzuriaga K, Tabak B, Garber M, Chen YH, Ziemniak C, McManus MM, Murray D, Strain MC, Richman D, Chun TW, Cunningham CK, Persaud D. HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment. J Infect Dis. 2014 Nov 15; 210(10):1529-38. PMID: 24850788; PMCID: PMC4215073.
    57. Gianella S, Massanella M, Richman D, Little SJ, Spina CA, Vargas MV, Lada SM, Daar ES, Dube MP, Haubrich RH, Morris SR, Smith DM. Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment. J Virol. 2014 Jul; 88(14):7818-27. PMID: 24789781; PMCID: PMC4097769.
    58. Karris MY, Kao YT, Patel D, Dawson M, Woods SP, Vaida F, Spina C, Richman D, Little S, Smith DM. Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. AIDS. 2014 Mar 27; 28(6):841-9. PMID: 24401640; PMCID: PMC4049563.
    59. Archin NM, Bateson R, Tripathy MK, Crooks AM, Yang KH, Dahl NP, Kearney MF, Anderson EM, Coffin JM, Strain MC, Richman D, Robertson KR, Kashuba AD, Bosch RJ, Hazuda DJ, Kuruc JD, Eron JJ, Margolis DM. HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat. J Infect Dis. 2014 Sep 01; 210(5):728-35. PMID: 24620025; PMCID: PMC4148603.
    60. Richman D. Editorial Commentary: Extending HIV drug resistance testing to low levels of plasma viremia. Clin Infect Dis. 2014 Apr; 58(8):1174-5. PMID: 24429434.
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    61. Chaillon A, Gianella S, Wertheim JO, Richman D, Mehta SR, Smith DM. HIV migration between blood and cerebrospinal fluid or semen over time. J Infect Dis. 2014 May 15; 209(10):1642-52. PMID: 24302756; PMCID: PMC3997580.
    62. Wagner GA, Pacold ME, Kosakovsky Pond SL, Caballero G, Chaillon A, Rudolph AE, Morris SR, Little SJ, Richman D, Smith DM. Incidence and prevalence of intrasubtype HIV-1 dual infection in at-risk men in the United States. J Infect Dis. 2014 Apr 01; 209(7):1032-8. PMID: 24273040; PMCID: PMC3952674.
    63. Tatro ET, Purnajo I, Richman D, Smith DM, Gianella S. Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation. Clin Vaccine Immunol. 2014 Jan; 21(1):46-50. PMID: 24173027; PMCID: PMC3910916.
    64. Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun TW, Strain M, Richman D, Luzuriaga K. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med. 2013 Nov 07; 369(19):1828-35. PMID: 24152233; PMCID: PMC3954754.
    65. Wertheim JO, Leigh Brown AJ, Hepler NL, Mehta SR, Richman D, Smith DM, Kosakovsky Pond SL. The global transmission network of HIV-1. J Infect Dis. 2014 Jan 15; 209(2):304-13. PMID: 24151309.
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    66. Chaillon A, Gianella S, Vazquez H, Ignacio C, Zweig AC, Richman D, Smith DM. Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy. AIDS Res Hum Retroviruses. 2014 Feb; 30(2):165-9. PMID: 24020934; PMCID: PMC3910474.
    67. Chaillon A, Wagner GA, Hepler NL, Little SJ, Kosakovsky Pond SL, Caballero G, Pacold ME, Phung P, Wrin T, Richman D, Wertheim JO, Smith DM. Dynamics of viral evolution and neutralizing antibody response after HIV-1 superinfection. J Virol. 2013 Dec; 87(23):12737-44. PMID: 24049166; PMCID: PMC3838120.
    68. DeBoever C, Reid EG, Smith EN, Wang X, Dumaop W, Harismendy O, Carson D, Richman D, Masliah E, Frazer KA. Whole transcriptome sequencing enables discovery and analysis of viruses in archived primary central nervous system lymphomas. PLoS One. 2013; 8(9):e73956. PMID: 24023918; PMCID: PMC3762708.
    69. Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman D, Deeks SG. Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. J Infect Dis. 2013 Nov 01; 208(9):1436-42. PMID: 23975885; PMCID: PMC3789577.
    70. Gianella S, Morris SR, Tatro E, Vargas MV, Haubrich RH, Daar ES, Dube MP, Richman D, Little SJ, Smith DM. Virologic correlates of anti-CMV IgG levels in HIV-1-infected men. J Infect Dis. 2014 Feb 01; 209(3):452-6. PMID: 23964106; PMCID: PMC3883163.
    71. Massanella M, Singhania A, Beliakova-Bethell N, Pier R, Lada SM, White CH, Pérez-Santiago J, Blanco J, Richman D, Little SJ, Woelk CH. Differential gene expression in HIV-infected individuals following ART. Antiviral Res. 2013 Nov; 100(2):420-8. PMID: 23933117; PMCID: PMC3899918.
    72. Pérez-Santiago J, Gianella S, Massanella M, Spina CA, Karris MY, Var SR, Patel D, Jordan PS, Young JA, Little SJ, Richman D, Smith DM. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013 Jul 31; 27(12):1921-31. PMID: 24180001; PMCID: PMC3816380.
    73. Hightower GK, May SJ, Pérez-Santiago J, Pacold ME, Wagner GA, Little SJ, Richman D, Mehta SR, Smith DM, Pond SL. HIV-1 clade B pol evolution following primary infection. PLoS One. 2013; 8(6):e68188. PMID: 23840830; PMCID: PMC3695957.
    74. Xu Y, Duggineni S, Espitia S, Richman D, An J, Huang Z. A synthetic bivalent ligand of CXCR4 inhibits HIV infection. Biochem Biophys Res Commun. 2013 Jun 14; 435(4):646-50. PMID: 23688427; PMCID: PMC3752463.
    75. Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 2013; 9(5):e1003347. PMID: 23671416; PMCID: PMC3649997.
    76. Rouzioux C, Richman D. How to best measure HIV reservoirs? Curr Opin HIV AIDS. 2013 May; 8(3):170-5. PMID: 23564004; PMCID: PMC3763804.
    77. Wagner GA, Pacold ME, Vigil E, Caballero G, Morris SR, Kosakovsky Pond SL, Little SJ, Richman D, Gianella S, Smith DM. Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection. J Infect Dis. 2013 Jul 15; 208(2):271-4. PMID: 23599311; PMCID: PMC3685231.
    78. Gianella S, Smith DM, Vargas MV, Little SJ, Richman D, Daar ES, Dube MP, Zhang F, Ginocchio CC, Haubrich RH, Morris SR. Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men. Clin Infect Dis. 2013 Aug; 57(3):441-7. PMID: 23595831; PMCID: PMC3703105.
    79. Strain MC, Lada SM, Luong T, Rought SE, Gianella S, Terry VH, Spina CA, Woelk CH, Richman D. Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One. 2013; 8(4):e55943. PMID: 23573183; PMCID: PMC3616050.
    80. Katlama C, Deeks SG, Autran B, Martinez-Picado J, van Lunzen J, Rouzioux C, Miller M, Vella S, Schmitz JE, Ahlers J, Richman D, Sekaly RP. Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet. 2013 Jun 15; 381(9883):2109-17. PMID: 23541541; PMCID: PMC3815451.
    81. Strain MC, Richman D. New assays for monitoring residual HIV burden in effectively treated individuals. Curr Opin HIV AIDS. 2013 Mar; 8(2):106-10. PMID: 23314907; PMCID: PMC3754420.
    82. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman D, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 2013 Feb; 9(2):e1003174. PMID: 23459007; PMCID: PMC3573107.
    83. Johnson VA, Calvez V, Gunthard HF, Paredes R, Pillay D, Shafer RW, Wensing AM, Richman D. Update of the drug resistance mutations in HIV-1: March 2013. Top Antivir Med. 2013 Feb-Mar; 21(1):6-14. PMID: 23596273.
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    84. Le T, Wright EJ, Smith DM, He W, Catano G, Okulicz JF, Young JA, Clark RA, Richman D, Little SJ, Ahuja SK. Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med. 2013 Jan 17; 368(3):218-30. PMID: 23323898; PMCID: PMC3657555.
    85. Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman D, Spina CA, Woelk CH. Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS. 2013 Jan 02; 27(1):29-37. PMID: 23221426; PMCID: PMC3752851.
    86. Gianella S, Morris SR, Anderson C, Spina CA, Vargas MV, Young JA, Richman D, Little SJ, Smith DM. Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. AIDS. 2013 Jan 02; 27(1):39-47. PMID: 22739399; PMCID: PMC3769229.
    87. Wie SH, Du P, Luong TQ, Rought SE, Beliakova-Bethell N, Lozach J, Corbeil J, Kornbluth RS, Richman D, Woelk CH. HIV downregulates interferon-stimulated genes in primary macrophages. J Interferon Cytokine Res. 2013 Feb; 33(2):90-5. PMID: 23276142; PMCID: PMC3573720.
    88. Gianella S, Anderson CM, Vargas MV, Richman D, Little SJ, Morris SR, Smith DM. Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA. J Infect Dis. 2013 Mar 15; 207(6):898-902. PMID: 23275608; PMCID: PMC3571441.
    89. Gianella S, Morris SR, Vargas MV, Young JA, Callahan B, Richman D, Little SJ, Smith DM. Role of seminal shedding of herpesviruses in HIV Type 1 Transmission. J Infect Dis. 2013 Jan 15; 207(2):257-61. PMID: 23148284; PMCID: PMC3532824.
    90. Gianella S, Mehta SR, Strain MC, Young JA, Vargas MV, Little SJ, Richman D, Kosakovsky Pond SL, Smith DM. Impact of seminal cytomegalovirus replication on HIV-1 dynamics between blood and semen. J Med Virol. 2012 Nov; 84(11):1703-9. PMID: 22997072; PMCID: PMC3472447.
    91. Stadeli KM, Richman D. Rates of emergence of HIV drug resistance in resource-limited settings: a systematic review. Antivir Ther. 2013; 18(1):115-23. PMID: 23052978; PMCID: PMC4295493.
    92. Gianella S, Mehta SR, Young JA, Vargas MV, Little SJ, Richman D, Kosakovsky Pond SL, Smith DM. Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells. Virology. 2012 Dec 05; 434(1):2-4. PMID: 23040890; PMCID: PMC3485073.
    93. Hightower GK, Wong JK, Letendre SL, Umlauf AA, Ellis RJ, Ignacio CC, Heaton RK, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Grant I, Little SJ, Richman D, Kosakovsky Pond SL, Smith DM. Higher HIV-1 genetic diversity is associated with AIDS and neuropsychological impairment. Virology. 2012 Nov 25; 433(2):498-505. PMID: 22999095; PMCID: PMC3466337.
    94. Soto PC, Karris MY, Spina CA, Richman D, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med (Berl). 2013 Feb; 91(2):261-70. PMID: 22945238; PMCID: PMC3558668.
    95. Thompson MA, Aberg JA, Hoy JF, Telenti A, Benson C, Cahn P, Eron JJ, Günthard HF, Hammer SM, Reiss P, Richman D, Rizzardini G, Thomas DL, Jacobsen DM, Volberding PA. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA. 2012 Jul 25; 308(4):387-402. PMID: 22820792.
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    96. Richman D. Antiretroviral drug resistance in resource-limited settings. Lancet. 2012 Oct 06; 380(9849):1210-1. PMID: 22828483.
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    97. Tilghman MW, May S, Pérez-Santiago J, Ignacio CC, Little SJ, Richman D, Smith DM. A combined screening platform for HIV treatment failure and resistance. PLoS One. 2012; 7(4):e35401. PMID: 22563383; PMCID: PMC3338506.
    98. Choi JY, Hightower GK, Wong JK, Heaton R, Woods S, Grant I, Marcotte TD, Ellis RJ, Letendre SL, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Richman D, Smith DM. Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat. J Neurovirol. 2012 Apr; 18(2):81-90. PMID: 22528397.
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    99. Mehta SR, Kosakovsky Pond SL, Young JA, Richman D, Little S, Smith DM. Associations between phylogenetic clustering and HLA profile among HIV-infected individuals in San Diego, California. J Infect Dis. 2012 May 15; 205(10):1529-33. PMID: 22448013; PMCID: PMC3415817.
    100. Agrawal A, DeSoto J, Fullagar JL, Maddali K, Rostami S, Richman D, Pommier Y, Cohen SM. Probing chelation motifs in HIV integrase inhibitors. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2251-6. PMID: 22308350; PMCID: PMC3289312.
    101. Pacold ME, Pond SL, Wagner GA, Delport W, Bourque DL, Richman D, Little SJ, Smith DM. Clinical, virologic, and immunologic correlates of HIV-1 intraclade B dual infection among men who have sex with men. AIDS. 2012 Jan 14; 26(2):157-65. PMID: 22045341; PMCID: PMC3807679.
    102. Gianella S, Strain MC, Rought SE, Vargas MV, Little SJ, Richman D, Spina CA, Smith DM. Associations between virologic and immunologic dynamics in blood and in the male genital tract. J Virol. 2012 Feb; 86(3):1307-15. PMID: 22114342; PMCID: PMC3264378.
    103. Johnson VA, Calvez V, Günthard HF, Paredes R, Pillay D, Shafer R, Wensing AM, Richman D. 2011 update of the drug resistance mutations in HIV-1. Top Antivir Med. 2011 Nov; 19(4):156-64. PMID: 22156218.
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    104. Jeong J, Kim SR, Lee SH, Lim JH, Choi JI, Park JS, Chang CL, Choi JY, Richman D, Smith DM. The Use of High Performance Liquid Chromatography to Speciate and Characterize the Epidemiology of Mycobacteria. Lab Med. 2011 Oct 01; 42(10):612-617. PMID: 24443588.
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    105. Magee WC, Valiaeva N, Beadle JR, Richman D, Hostetler KY, Evans DH. Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action. Antimicrob Agents Chemother. 2011 Nov; 55(11):5063-72. PMID: 21896914; PMCID: PMC3195056.
    106. Homann S, Smith D, Little S, Richman D, Guatelli J. Upregulation of BST-2/Tetherin by HIV infection in vivo. J Virol. 2011 Oct; 85(20):10659-68. PMID: 21849457; PMCID: PMC3187519.
    107. Gianella S, Delport W, Pacold ME, Young JA, Choi JY, Little SJ, Richman D, Kosakovsky Pond SL, Smith DM. Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants. J Virol. 2011 Aug; 85(16):8359-67. PMID: 21632754; PMCID: PMC3147985.
    108. Tilghman MW, Guerena DD, Licea A, Pérez-Santiago J, Richman D, May S, Smith DM. Pooled nucleic acid testing to detect antiretroviral treatment failure in Mexico. J Acquir Immune Defic Syndr. 2011 Mar 01; 56(3):e70-4. PMID: 21124228; PMCID: PMC3039117.
    109. Meditz AL, MaWhinney S, Allshouse A, Feser W, Markowitz M, Little S, Hecht R, Daar ES, Collier AC, Margolick J, Kilby JM, Routy JP, Conway B, Kaldor J, Levy J, Schooley R, Cooper DA, Altfeld M, Richman D, Connick E. Sex, race, and geographic region influence clinical outcomes following primary HIV-1 infection. J Infect Dis. 2011 Feb 15; 203(4):442-51. PMID: 21245157; PMCID: PMC3071223.
    110. Richman D. Introduction: challenges to finding a cure for HIV infection. Curr Opin HIV AIDS. 2011 Jan; 6(1):1-3. PMID: 21242886; PMCID: PMC3077900.
    111. Mascolini M, Mellors JW, Richman D, Boucher CA, Larder BA. HIV and hepatitis virus resistance to antivirals: review of data from the XIX International HIV and Hepatitis Virus Drug Resistance Workshop and curative strategies. Antivir Ther. 2011; 16(2):263-86. PMID: 21447877.
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    112. Johnson VA, Brun-Vézinet F, Clotet B, Günthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman D. Update of the drug resistance mutations in HIV-1: December 2010. Top HIV Med. 2010 Dec; 18(5):156-63. PMID: 21245516.
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    113. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science. 2010 Dec 10; 330(6010):1551-7. PMID: 21051598; PMCID: PMC3235490.
    114. Pacold M, Smith D, Little S, Cheng PM, Jordan P, Ignacio C, Richman D, Pond SK. Comparison of methods to detect HIV dual infection. AIDS Res Hum Retroviruses. 2010 Dec; 26(12):1291-8. PMID: 20954840; PMCID: PMC3011997.
    115. Smith D, Delport W, Butler D, Little S, Richman D, Pond SK. Response to Comment on "The Origins of Sexually Transmitted HIV Among Men Who Have Sex with Men" Sci Transl Med. 2010 Sep; 2(50):501r1. PMID: 21532938.
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    116. Gianella S, Richman D. Minority variants of drug-resistant HIV. J Infect Dis. 2010 Sep 01; 202(5):657-66. PMID: 20649427; PMCID: PMC2916955.
    117. Thompson MA, Aberg JA, Cahn P, Montaner JS, Rizzardini G, Telenti A, Gatell JM, Günthard HF, Hammer SM, Hirsch MS, Jacobsen DM, Reiss P, Richman D, Volberding PA, Yeni P, Schooley RT. Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel. JAMA. 2010 Jul 21; 304(3):321-33. PMID: 20639566.
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    118. Morris SR, Little SJ, Cunningham T, Garfein RS, Richman D, Smith DM. Evaluation of an HIV nucleic acid testing program with automated Internet and voicemail systems to deliver results. Ann Intern Med. 2010 Jun 15; 152(12):778-85. PMID: 20547906; PMCID: PMC2922925.
    119. Manosuthi W, Butler DM, Chantratita W, Sukasem C, Richman D, Smith DM. Patients infected with HIV type 1 subtype CRF01_AE and failing first-line nevirapine- and efavirenz-based regimens demonstrate considerable cross-resistance to etravirine. AIDS Res Hum Retroviruses. 2010 Jun; 26(6):609-11. PMID: 20507208; PMCID: PMC2982719.
    120. Markowitz M, Vaida F, Hare CB, Boden D, Mohri H, Hecht FM, Kalayjian RC, Conrad A, Mildvan D, Aberg J, Hogan C, Kilby JM, Balfour HH, Schafer K, Richman D, Little S. The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection. J Infect Dis. 2010 May 01; 201(9):1298-302. PMID: 20235838; PMCID: PMC2851487.
    121. Goicoechea M, Jain S, Bi L, Kemper C, Daar ES, Diamond C, Ha B, Flaherty J, Sun S, Richman D, Louie S, Haubrich R. Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients. AIDS. 2010 Mar 13; 24(5):707-16. PMID: 20087154.
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    122. Butler DM, Delport W, Kosakovsky Pond SL, Lakdawala MK, Cheng PM, Little SJ, Richman D, Smith DM. The origins of sexually transmitted HIV among men who have sex with men. Sci Transl Med. 2010 Feb 10; 2(18):18re1. PMID: 20371483; PMCID: PMC2945226.
    123. Manosuthi W, Butler DM, Pérez-Santiago J, Poon AF, Pillai SK, Mehta SR, Pacold ME, Richman D, Pond SK, Smith DM. Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure. AIDS. 2010 Jan 28; 24(3):411-6. PMID: 20009919; PMCID: PMC2913588.
    124. Woelk CH, Beliakova-Bethell N, Goicoechea M, Zhao Y, Du P, Rought SE, Lozach J, Pérez-Santiago J, Richman D, Smith DM, Little SJ. Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery. AIDS. 2010 Jan 16; 24(2):217-22. PMID: 19952713; PMCID: PMC2915828.
    125. Poon AF, Swenson LC, Dong WW, Deng W, Kosakovsky Pond SL, Brumme ZL, Mullins JI, Richman D, Harrigan PR, Frost SD. Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1. Mol Biol Evol. 2010 Apr; 27(4):819-32. PMID: 19955476; PMCID: PMC2877536.
    126. Goicoechea M, Jain S, Bi L, Sun S, Smith G, Ha B, Richman D, Louie S, Haubrich R. Interlaboratory measurement differences in intracellular carbovir triphosphate concentrations in HIV-infected patients: sources of variability in processing, shipping, and quantitation. J Clin Pharmacol. 2010 Aug; 50(8):968-74. PMID: 19952374.
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    127. Johnson VA, Brun-Vezinet F, Clotet B, Gunthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman D. Update of the drug resistance mutations in HIV-1: December 2009. Top HIV Med. 2009 Dec; 17(5):138-45. PMID: 20068260.
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    128. Smith DM, May SJ, Pérez-Santiago J, Strain MC, Ignacio CC, Haubrich RH, Richman D, Benson CA, Little SJ. The use of pooled viral load testing to identify antiretroviral treatment failure. AIDS. 2009 Oct 23; 23(16):2151-8. PMID: 19730348; PMCID: PMC2915784.
    129. Montaner JS, Richman D, Hammer SM. Poor agreement between 2 assays for measuring low levels of HIV-1 viral load. Clin Infect Dis. 2009 Oct 15; 49(8):1283-4. PMID: 19780662.
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    130. Hightower GK, Letendre SL, Cherner M, Gibson SA, Ellis RJ, Wolfson TJ, Gamst AC, Ignacio CC, Heaton RK, Grant I, Richman D, Smith DM. Select resistance-associated mutations in blood are associated with lower CSF viral loads and better neuropsychological performance. Virology. 2009 Nov 25; 394(2):243-8. PMID: 19762060; PMCID: PMC3046809.
    131. Butler DM, Pacold ME, Jordan PS, Richman D, Smith DM. The efficiency of single genome amplification and sequencing is improved by quantitation and use of a bioinformatics tool. J Virol Methods. 2009 Dec; 162(1-2):280-3. PMID: 19698751; PMCID: PMC2761514.
    132. Jordan PS, Poon A, Eron J, Squires K, Ignacio C, Richman D, Smith DM. A novel codon insert in protease of clade B HIV type 1. AIDS Res Hum Retroviruses. 2009 May; 25(5):547-50. PMID: 19397401; PMCID: PMC2749665.
    133. Eron JJ, Park JG, Haubrich R, Aweeka F, Bastow B, Pakes GE, Yu S, Wu H, Richman D. Predictive value of pharmacokinetics-adjusted phenotypic susceptibility on response to ritonavir-enhanced protease inhibitors (PIs) in human immunodeficiency virus-infected subjects failing prior PI therapy. Antimicrob Agents Chemother. 2009 Jun; 53(6):2335-41. PMID: 19307363; PMCID: PMC2687257.
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    135. Yukl S, Pillai S, Li P, Chang K, Pasutti W, Ahlgren C, Havlir D, Strain M, Günthard H, Richman D, Rice AP, Daar E, Little S, Wong JK. Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity. Virology. 2009 Apr 25; 387(1):98-108. PMID: 19268337; PMCID: PMC4474533.
    136. Smith DM, May SJ, Tweeten S, Drumright L, Pacold ME, Kosakovsky Pond SL, Pesano RL, Lie YS, Richman D, Frost SD, Woelk CH, Little SJ. A public health model for the molecular surveillance of HIV transmission in San Diego, California. AIDS. 2009 Jan 14; 23(2):225-32. PMID: 19098493; PMCID: PMC2644048.
    137. Mascolini M, Boucher CA, Mellors JW, Larder BA, Richman D. Progress in basic and clinical research on HIV resistance: report on the XVIII International HIV Drug Resistance Workshop. Antivir Ther. 2009; 14(7):1015-37. PMID: 19918107.
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    138. Nugent CT, Nodelman V, Giachetti C, Richman D, Looney DJ. Evaluation of a highly sensitive qualitative human immunodeficiency virus type 1 (HIV-1) RNA assay for detection of HIV-1 suppression. J Clin Microbiol. 2009 Mar; 47(3):833-6. PMID: 19116355; PMCID: PMC2650919.
    139. Smith DM, Zárate S, Shao H, Pillai SK, Letendre SL, Wong JK, Richman D, Frost SD, Ellis RJ. Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations. Virology. 2009 Mar 01; 385(1):204-8. PMID: 19100592; PMCID: PMC2794037.
    140. Johnson VA, Brun-Vezinet F, Clotet B, Gunthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman D. Update of the Drug Resistance Mutations in HIV-1. Top HIV Med. 2008 Dec; 16(5):138-45. PMID: 19106428.
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    141. Precopio ML, Butterfield TR, Casazza JP, Little SJ, Richman D, Koup RA, Roederer M. Optimizing peptide matrices for identifying T-cell antigens. Cytometry A. 2008 Nov; 73(11):1071-8. PMID: 18781655.
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    142. Binley JM, Lybarger EA, Crooks ET, Seaman MS, Gray E, Davis KL, Decker JM, Wycuff D, Harris L, Hawkins N, Wood B, Nathe C, Richman D, Tomaras GD, Bibollet-Ruche F, Robinson JE, Morris L, Shaw GM, Montefiori DC, Mascola JR. Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C. J Virol. 2008 Dec; 82(23):11651-68. PMID: 18815292.
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    143. Butler DM, Smith DM, Cachay ER, Hightower GK, Nugent CT, Richman D, Little SJ. Herpes simplex virus 2 serostatus and viral loads of HIV-1 in blood and semen as risk factors for HIV transmission among men who have sex with men. AIDS. 2008 Aug 20; 22(13):1667-71. PMID: 18670228; PMCID: PMC2653089.
    144. Hammer SM, Eron JJ, Reiss P, Schooley RT, Thompson MA, Walmsley S, Cahn P, Fischl MA, Gatell JM, Hirsch MS, Jacobsen DM, Montaner JS, Richman D, Yeni PG, Volberding PA. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA. 2008 Aug 06; 300(5):555-70. PMID: 18677028.
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    145. Hirsch MS, Günthard HF, Schapiro JM, Brun-Vézinet F, Clotet B, Hammer SM, Johnson VA, Kuritzkes DR, Mellors JW, Pillay D, Yeni PG, Jacobsen DM, Richman D. Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Top HIV Med. 2008 Aug-Sep; 16(3):266-85. PMID: 19856548.
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    146. Grant RM, Hamer D, Hope T, Johnston R, Lange J, Lederman MM, Lieberman J, Miller CJ, Moore JP, Mosier DE, Richman D, Schooley RT, Springer MS, Veazey RS, Wainberg MA. Whither or wither microbicides? Science. 2008 Jul 25; 321(5888):532-4. PMID: 18653884; PMCID: PMC2835691.
    147. Hirsch MS, Günthard HF, Schapiro JM, Brun-Vézinet F, Clotet B, Hammer SM, Johnson VA, Kuritzkes DR, Mellors JW, Pillay D, Yeni PG, Jacobsen DM, Richman D. Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Clin Infect Dis. 2008 Jul 15; 47(2):266-85. PMID: 18549313.
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    149. Liu L, May S, Richman D, Hecht FM, Markowitz M, Daar ES, Routy JP, Margolick JB, Collier AC, Woelk CH, Little SJ, Smith DM. Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance. AIDS. 2008 Apr 23; 22(7):835-9. PMID: 18427201; PMCID: PMC2716722.
    150. Cachay ER, Frost SD, Poon AF, Looney D, Rostami SM, Pacold ME, Richman D, Little SJ, Smith DM. Herpes simplex virus type 2 acquisition during recent HIV infection does not influence plasma HIV levels. J Acquir Immune Defic Syndr. 2008 Apr 15; 47(5):592-6. PMID: 18197122; PMCID: PMC2630881.
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    152. Ahuja SK, Kulkarni H, Catano G, Agan BK, Camargo JF, He W, O'Connell RJ, Marconi VC, Delmar J, Eron J, Clark RA, Frost S, Martin J, Ahuja SS, Deeks SG, Little S, Richman D, Hecht FM, Dolan MJ. CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals. Nat Med. 2008 Apr; 14(4):413-20. PMID: 18376407; PMCID: PMC2630879.
    153. Little SJ, Frost SD, Wong JK, Smith DM, Pond SL, Ignacio CC, Parkin NT, Petropoulos CJ, Richman D. Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection. J Virol. 2008 Jun; 82(11):5510-8. PMID: 18353964; PMCID: PMC2395184.
    154. Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, Spina CA, Richman D, Wong JK. Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. J Infect Dis. 2008 Feb 01; 197(3):411-9. PMID: 18248304.
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    155. Frost SD, Trkola A, Günthard HF, Richman D. Antibody responses in primary HIV-1 infection. Curr Opin HIV AIDS. 2008 Jan; 3(1):45-51. PMID: 19372943.
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    156. Mascolini M, Larder BA, Boucher CA, Richman D, Mellors JW. Broad advances in understanding HIV resistance to antiretrovirals: report on the XVII International HIV Drug Resistance Workshop. Antivir Ther. 2008; 13(8):1097-113. PMID: 19195337.
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    157. Mascolini M, Richman D, Larder B, Mellors J, Boucher CA. Clinical implications of resistance to antiretrovirals: new resistance technologies and interpretations. Antivir Ther. 2008; 13(2):319-34. PMID: 18505183.
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    158. Pawlotsky JM, Dusheiko G, Hatzakis A, Lau D, Lau G, Liang TJ, Locarnini S, Martin P, Richman D, Zoulim F. Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations for a standardized approach. Gastroenterology. 2008 Feb; 134(2):405-15. PMID: 18242209.
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    159. Poon AF, Kosakovsky Pond SL, Richman D, Frost SD. Mapping protease inhibitor resistance to human immunodeficiency virus type 1 sequence polymorphisms within patients. J Virol. 2007 Dec; 81(24):13598-607. PMID: 17913806; PMCID: PMC2168824.
    160. Johnson VA, Brun-Vézinet F, Clotet B, Günthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman D. Update of the drug resistance mutations in HIV-1: 2007. Top HIV Med. 2007 Aug-Sep; 15(4):119-25. PMID: 17720996.
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    161. Smith DM, Wong JK, Shao H, Hightower GK, Mai SH, Moreno JM, Ignacio CC, Frost SD, Richman D, Little SJ. Long-term persistence of transmitted HIV drug resistance in male genital tract secretions: implications for secondary transmission. J Infect Dis. 2007 Aug 01; 196(3):356-60. PMID: 17597449.
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    162. Dhillon AK, Donners H, Pantophlet R, Johnson WE, Decker JM, Shaw GM, Lee FH, Richman D, Doms RW, Vanham G, Burton DR. Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors. J Virol. 2007 Jun; 81(12):6548-62. PMID: 17409160; PMCID: PMC1900098.
    163. Woelk CH, Frost SD, Richman D, Higley PE, Kosakovsky Pond SL. Evolution of the interferon alpha gene family in eutherian mammals. Gene. 2007 Aug 01; 397(1-2):38-50. PMID: 17512142; PMCID: PMC2174272.
    164. Cachay ER, Frost SD, Richman D, Smith DM, Little SJ. Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection. J Infect Dis. 2007 May 01; 195(9):1270-7. PMID: 17396995.
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    165. Poon AF, Kosakovsky Pond SL, Bennett P, Richman D, Leigh Brown AJ, Frost SD. Adaptation to human populations is revealed by within-host polymorphisms in HIV-1 and hepatitis C virus. PLoS Pathog. 2007 Mar; 3(3):e45. PMID: 17397261; PMCID: PMC1839164.
    166. Mascolini M, Boucher C, Larder B, Mellors J, Richman D. Key reports from the XV International HIV Drug Resistance Workshop 2006. Antivir Ther. 2007; 12(1):131-45. PMID: 17503758.
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    167. Richman D. Advances in the management of HIV-HBV coinfection. Antivir Ther. 2007; 12 Suppl 3:H1. PMID: 18284177.
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    168. Smith D, Moini N, Pesano R, Cachay E, Aiem H, Lie Y, Richman D, Little S. Clinical utility of HIV standard genotyping among antiretroviral-naive individuals with unknown duration of infection. Clin Infect Dis. 2007 Feb 01; 44(3):456-8. PMID: 17205459.
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    169. Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, Kuritzkes DR, Lederman MM, Malim MH, Marx PA, McCune JM, McMichael A, Miller C, Miller V, Montagnier L, Montefiori DC, Moore JP, Nixon DF, Overbaugh J, Pauza CD, Richman D, Saag MS, Sattentau Q, Schooley RT, Shattock R, Shaw GM, Stevenson M, Trkola A, Wainberg MA, Weiss RA, Wolinsky S, Zack JA. A plea for justice for jailed medical workers. Science. 2006 Nov 10; 314(5801):924-5. PMID: 17062652.
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    170. Smith DM, Strain MC, Frost SD, Pillai SK, Wong JK, Wrin T, Liu Y, Petropolous CJ, Daar ES, Little SJ, Richman D. Lack of neutralizing antibody response to HIV-1 predisposes to superinfection. Virology. 2006 Nov 10; 355(1):1-5. PMID: 16962152.
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    171. Hammer SM, Saag MS, Schechter M, Montaner JS, Schooley RT, Jacobsen DM, Thompson MA, Carpenter CC, Fischl MA, Gazzard BG, Gatell JM, Hirsch MS, Katzenstein DA, Richman D, Vella S, Yeni PG, Volberding PA. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel. JAMA. 2006 Aug 16; 296(7):827-43. PMID: 16905788.
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    172. Hammer SM, Saag MS, Schechter M, Montaner JS, Schooley RT, Jacobsen DM, Thompson MA, Carpenter CC, Fischl MA, Gazzard BG, Gatell JM, Hirsch MS, Katzenstein DA, Richman D, Vella S, Yeni PG, Volberding PA. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society--USA panel. Top HIV Med. 2006 Aug-Sep; 14(3):827-43. PMID: 17016878.
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    174. Day JR, Martínez LE, Sásik R, Hitchin DL, Dueck ME, Richman D, Guatelli JC. A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay. J Virol Methods. 2006 Oct; 137(1):125-33. PMID: 16876264.
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    175. Pond SL, Frost SD, Grossman Z, Gravenor MB, Richman D, Brown AJ. Adaptation to different human populations by HIV-1 revealed by codon-based analyses. PLoS Comput Biol. 2006 Jun 23; 2(6):e62. PMID: 16789820; PMCID: PMC1480537.
    176. Pillai SK, Pond SL, Liu Y, Good BM, Strain MC, Ellis RJ, Letendre S, Smith DM, Günthard HF, Grant I, Marcotte TD, McCutchan JA, Richman D, Wong JK. Genetic attributes of cerebrospinal fluid-derived HIV-1 env. Brain. 2006 Jul; 129(Pt 7):1872-83. PMID: 16735456.
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    177. Richman D. Antiviral drug resistance. Antiviral Res. 2006 Sep; 71(2-3):117-21. PMID: 16621040.
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    178. Yuste E, Sanford HB, Carmody J, Bixby J, Little S, Zwick MB, Greenough T, Burton DR, Richman D, Desrosiers RC, Johnson WE. Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma. J Virol. 2006 Mar; 80(6):3030-41. PMID: 16501112; PMCID: PMC1395451.
    179. Kumar S, Choi WT, Dong CZ, Madani N, Tian S, Liu D, Wang Y, Pesavento J, Wang J, Fan X, Yuan J, Fritzsche WR, An J, Sodroski JG, Richman D, Huang Z. SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development. Chem Biol. 2006 Jan; 13(1):69-79. PMID: 16426973.
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    180. Boucher C, Larder B, Mellors J, Richman D. The XIVth International HIV Drug Resistance Workshop, Quebec City, Canada, June 2005. Antivir Ther. 2006; 11(5):653-65. PMID: 16964836.
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    181. Frost SD, Wrin T, Smith DM, Kosakovsky Pond SL, Liu Y, Paxinos E, Chappey C, Galovich J, Beauchaine J, Petropoulos CJ, Little SJ, Richman D. Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18514-9. PMID: 16339909; PMCID: PMC1310509.
    182. Johnson VA, Brun-Vezinet F, Clotet B, Conway B, Kuritzkes DR, Pillay D, Schapiro JM, Telenti A, Richman D. Update of the drug resistance mutations in HIV-1: Fall 2005. Top HIV Med. 2005 Oct-Nov; 13(4):125-31. PMID: 16304457.
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    183. Smith DM, Wong JK, Hightower GK, Ignacio CC, Koelsch KK, Petropoulos CJ, Richman D, Little SJ. HIV drug resistance acquired through superinfection. AIDS. 2005 Aug 12; 19(12):1251-6. PMID: 16052079.
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    184. Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman D, Mellors JW, Coffin JM, Bosch RJ, Margolis DM. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet. 2005 Aug 13-19; 366(9485):549-55. PMID: 16099290; PMCID: PMC1894952.
    185. Smith DM, Richman D, Little SJ. HIV superinfection. J Infect Dis. 2005 Aug 01; 192(3):438-44. PMID: 15995957.
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    186. Pillai SK, Kosakovsky Pond SL, Woelk CH, Richman D, Smith DM. Codon volatility does not reflect selective pressure on the HIV-1 genome. Virology. 2005 Jun 05; 336(2):137-43. PMID: 15892955.
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    187. Zolopa AR, Lazzeroni LC, Rinehart A, Vezinet FB, Clavel F, Collier A, Conway B, Gulick RM, Holodniy M, Perno CF, Shafer RW, Richman D, Wainberg MA, Kuritzkes DR. Accuracy, precision, and consistency of expert HIV type 1 genotype interpretation: an international comparison (The GUESS Study). Clin Infect Dis. 2005 Jul 01; 41(1):92-9. PMID: 15937768.
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    188. Daar ES, Richman D. Confronting the emergence of drug-resistant HIV type 1: impact of antiretroviral therapy on individual and population resistance. AIDS Res Hum Retroviruses. 2005 May; 21(5):343-57. PMID: 15929696.
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    189. Frost SD, Liu Y, Pond SL, Chappey C, Wrin T, Petropoulos CJ, Little SJ, Richman D. Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B. J Virol. 2005 May; 79(10):6523-7. PMID: 15858036; PMCID: PMC1091710.
    190. Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina CA, Richman D, Wong JK. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J Infect Dis. 2005 May 01; 191(9):1410-8. PMID: 15809898.
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    192. Haubrich RH, Kemper CA, Hellmann NS, Keiser PH, Witt MD, Tilles JG, Forthal DN, Leedom J, Leibowitz M, McCutchan JA, Richman D. A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575. AIDS. 2005 Feb 18; 19(3):295-302. PMID: 15718840.
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    193. Pillai SK, Good B, Pond SK, Wong JK, Strain MC, Richman D, Smith DM. Semen-specific genetic characteristics of human immunodeficiency virus type 1 env. J Virol. 2005 Feb; 79(3):1734-42. PMID: 15650198; PMCID: PMC544119.
    194. Yang OO, Daar ES, Jamieson BD, Balamurugan A, Smith DM, Pitt JA, Petropoulos CJ, Richman D, Little SJ, Brown AJ. Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strains. J Virol. 2005 Jan; 79(2):860-8. PMID: 15613314; PMCID: PMC538553.
    195. Crooks ET, Moore PL, Richman D, Robinson J, Crooks JA, Franti M, Schülke N, Binley JM. Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization. Hum Antibodies. 2005; 14(3-4):101-13. PMID: 16720980; PMCID: PMC2630880.
    196. Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman D, McMichael AJ, Jones EY, Rowland-Jones SL. HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med. 2004 Dec 20; 200(12):1547-57. PMID: 15596521; PMCID: PMC2212004.
    197. Woelk CH, Ottones F, Plotkin CR, Du P, Royer CD, Rought SE, Lozach J, Sasik R, Kornbluth RS, Richman D, Corbeil J. Interferon gene expression following HIV type 1 infection of monocyte-derived macrophages. AIDS Res Hum Retroviruses. 2004 Nov; 20(11):1210-22. PMID: 15588343.
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    198. Johnson VA, Brun-Vézinet F, Clotet B, Conway B, D'Aquila RT, Demeter LM, Kuritzkes DR, Pillay D, Schapiro JM, Telenti A, Richman D. Update of the drug resistance mutations in HIV-1: 2004. Top HIV Med. 2004 Oct-Nov; 12(4):119-24. PMID: 15516709.
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    199. Smith DM, Wong JK, Hightower GK, Ignacio CC, Koelsch KK, Daar ES, Richman D, Little SJ. Incidence of HIV superinfection following primary infection. JAMA. 2004 Sep 08; 292(10):1177-8. PMID: 15353529.
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    200. Smith DM, Kingery JD, Wong JK, Ignacio CC, Richman D, Little SJ. The prostate as a reservoir for HIV-1. AIDS. 2004 Jul 23; 18(11):1600-2. PMID: 15238781.
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    201. Yeni PG, Hammer SM, Hirsch MS, Saag MS, Schechter M, Carpenter CC, Fischl MA, Gatell JM, Gazzard BG, Jacobsen DM, Katzenstein DA, Montaner JS, Richman D, Schooley RT, Thompson MA, Vella S, Volberding PA. Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel. JAMA. 2004 Jul 14; 292(2):251-65. PMID: 15249575.
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    202. Richman D, Morton SC, Wrin T, Hellmann N, Berry S, Shapiro MF, Bozzette SA. The prevalence of antiretroviral drug resistance in the United States. AIDS. 2004 Jul 02; 18(10):1393-401. PMID: 15199315.
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    203. Yu Q, König R, Pillai S, Chiles K, Kearney M, Palmer S, Richman D, Coffin JM, Landau NR. Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome. Nat Struct Mol Biol. 2004 May; 11(5):435-42. PMID: 15098018.
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    204. Richman D. Benefits and limitations of testing for resistance to HIV drugs. J Antimicrob Chemother. 2004 Apr; 53(4):555-7. PMID: 15014064.
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    205. Leigh Brown AJ, Frost SD, Good B, Daar ES, Simon V, Markowitz M, Collier AC, Connick E, Conway B, Margolick JB, Routy JP, Corbeil J, Hellmann NS, Richman D, Little SJ. Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection. J Virol. 2004 Mar; 78(5):2242-6. PMID: 14963120; PMCID: PMC369210.
    206. Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, Dong T, Chesney G, Waters A, Easterbrook P, Dunbar PR, Shepherd D, Cerundolo V, Emery V, Griffiths P, Conlon C, McMichael AJ, Richman D, Rowland-Jones SL, Appay V. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004 Feb; 2(2):E20. PMID: 14966528; PMCID: PMC340937.
    207. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science. 2004 Jan 16; 303(5656):316. PMID: 14726576.
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    208. Richman D, Little SJ, Smith DM, Wrin T, Petropoulos C, Wong JK. HIV evolution and escape. Trans Am Clin Climatol Assoc. 2004; 115:289-303. PMID: 17060974; PMCID: PMC2263778.
    209. Gallant JE, Gerondelis PZ, Wainberg MA, Shulman NS, Haubrich RH, St Clair M, Lanier ER, Hellmann NS, Richman D. Nucleoside and nucleotide analogue reverse transcriptase inhibitors: a clinical review of antiretroviral resistance. Antivir Ther. 2003 Dec; 8(6):489-506. PMID: 14760883.
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    210. Gulick RM, Meibohm A, Havlir D, Eron JJ, Mosley A, Chodakewitz JA, Isaacs R, Gonzalez C, McMahon D, Richman D, Robertson M, Mellors JW. Six-year follow-up of HIV-1-infected adults in a clinical trial of antiretroviral therapy with indinavir, zidovudine, and lamivudine. AIDS. 2003 Nov 07; 17(16):2345-9. PMID: 14571186.
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    211. Johnson VA, Brun-Vézinet F, Clotet B, Conway B, D'Aquila RT, Demeter LM, Kuritzkes DR, Pillay D, Schapiro JM, Telenti A, Richman D. Drug resistance mutations in HIV-1. Top HIV Med. 2003 Nov-Dec; 11(6):215-21. PMID: 14724329.
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    212. Ali A, Pillai S, Ng H, Lubong R, Richman D, Jamieson BD, Ding Y, McElrath MJ, Guatelli JC, Yang OO. Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. J Immunol. 2003 Oct 15; 171(8):3999-4005. PMID: 14530319.
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    213. Haas DW, Wilkinson GR, Kuritzkes DR, Richman D, Nicotera J, Mahon LF, Sutcliffe C, Siminski S, Andersen J, Coughlin K, Clayton EW, Haines J, Marshak A, Saag M, Lawrence J, Gustavson J, Anne Bennett J, Christensen R, Matula MA, Wood AJ. A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG Protocol A5128. HIV Clin Trials. 2003 Sep-Oct; 4(5):287-300. PMID: 14583845.
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    214. Hirsch MS, Brun-Vézinet F, Clotet B, Conway B, Kuritzkes DR, D'Aquila RT, Demeter LM, Hammer SM, Johnson VA, Loveday C, Mellors JW, Richman D. Questions to and answers from the International AIDS Society-USA Resistance Testing Guidelines Panel. Top HIV Med. 2003 Jul-Aug; 11(4):150-4. PMID: 12876334.
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    215. Hirsch MS, Brun-Vézinet F, Clotet B, Conway B, Kuritzkes DR, D'Aquila RT, Demeter LM, Hammer SM, Johnson VA, Loveday C, Mellors JW, Jacobsen DM, Richman D. Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel. Clin Infect Dis. 2003 Jul 01; 37(1):113-28. PMID: 12830416.
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    216. Zaunders JJ, Moutouh-de Parseval L, Kitada S, Reed JC, Rought S, Genini D, Leoni L, Kelleher A, Cooper DA, Smith DE, Grey P, Estaquier J, Little S, Richman D, Corbeil J. Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2. J Infect Dis. 2003 Jun 01; 187(11):1735-47. PMID: 12751031.
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    217. Koelsch KK, Smith DM, Little SJ, Ignacio CC, Macaranas TR, Brown AJ, Petropoulos CJ, Richman D, Wong JK. Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus. AIDS. 2003 May 02; 17(7):F11-6. PMID: 12700477.
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    218. D'Aquila RT, Schapiro JM, Brun-Vézinet F, Clotet B, Conway B, Demeter LM, Grant RM, Johnson VA, Kuritzkes DR, Loveday C, Shafer RW, Richman D. Drug resistance mutations in HIV-1. Top HIV Med. 2003 May-Jun; 11(3):92-6. PMID: 12837968.
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    219. Richman D, Wrin T, Little SJ, Petropoulos CJ. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4144-9. PMID: 12644702; PMCID: PMC153062.
    220. Pillai S, Good B, Richman D, Corbeil J. A new perspective on V3 phenotype prediction. AIDS Res Hum Retroviruses. 2003 Feb; 19(2):145-9. PMID: 12643277.
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    221. Sheeter D, Du P, Rought S, Richman D, Corbeil J. Surface CD4 expression modulated by a cellular factor induced by HIV type 1 infection. AIDS Res Hum Retroviruses. 2003 Feb; 19(2):117-23. PMID: 12639247.
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    222. Leigh Brown AJ, Frost SD, Mathews WC, Dawson K, Hellmann NS, Daar ES, Richman D, Little SJ. Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population. J Infect Dis. 2003 Feb 15; 187(4):683-6. PMID: 12599087.
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    223. Anton PA, Mitsuyasu RT, Deeks SG, Scadden DT, Wagner B, Huang C, Macken C, Richman D, Christopherson C, Borellini F, Lazar R, Hege KM. Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects. AIDS. 2003 Jan 03; 17(1):53-63. PMID: 12478069.
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    224. Uckun FM, Pendergrass S, Venkatachalam TK, Qazi S, Richman D. Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations. Antimicrob Agents Chemother. 2002 Nov; 46(11):3613-6. PMID: 12384373; PMCID: PMC128707.
    225. D'Aquila RT. Drug Resistance Mutations in HIV-1. Top HIV Med. 2002 Nov-Dec; 10(5):21-25. PMID: 12717052.
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    226. Haubrich RH, Kemper CA, Hellmann NS, Keiser PH, Witt MD, Forthal DN, Leedom J, Leibowitz M, Whitcomb JM, Richman D, McCutchan JA. The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis. AIDS. 2002 Oct 18; 16(15):F33-40. PMID: 12370520.
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    227. Bennett KK, DeGruttola VG, Marschner IC, Havlir DV, Richman D. Baseline predictors of CD4 T-lymphocyte recovery with combination antiretroviral therapy. J Acquir Immune Defic Syndr. 2002 Sep 01; 31(1):20-6. PMID: 12352146.
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    228. Little SJ, Holte S, Routy JP, Daar ES, Markowitz M, Collier AC, Koup RA, Mellors JW, Connick E, Conway B, Kilby M, Wang L, Whitcomb JM, Hellmann NS, Richman D. Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med. 2002 Aug 08; 347(6):385-94. PMID: 12167680.
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    229. Yeni PG, Hammer SM, Carpenter CC, Cooper DA, Fischl MA, Gatell JM, Gazzard BG, Hirsch MS, Jacobsen DM, Katzenstein DA, Montaner JS, Richman D, Saag MS, Schechter M, Schooley RT, Thompson MA, Vella S, Volberding PA. Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society-USA Panel. JAMA. 2002 Jul 10; 288(2):222-35. PMID: 12095387.
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