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    Alysson Muotri

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-534-9320
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      The complexity of the human brain, with thousands of neuronal types, permits the development of sophisticated behavioral repertoires, such as language, tool use, self-awareness, symbolic thought, cultural learning and consciousness. From such dynamic complexity emerged extraordinary technological and artistic masterpieces in a relatively short cultural history. Moreover, brain complexity has a creative purpose. Understanding what produces neuronal diversification during brain development has been a longstanding challenge for neuroscientists and may bring insights into the evolution of human cognition.
      The Muotri lab explores mobile elements as generators of diversity during neuronal differentiation. These mobile elements may be part of a conserved genetic core process responsible for evoking facilitated complex non-random phenotypical variation upon which selection may act. The lab uses animal models, neural stem cells, human and other primates’ pluripotent cells and several molecular tools to investigate fundamental mechanisms of brain development, evolution and neural disorders, including Autism Spectrum Disorders.

      Research Focus Areas:

    • Developmental Biology

    • DNA Replication and Repair

    • Genetics and Genomics

    • Gene Expression and Regulation

    • Neurodevelopment and Neurodegenerative Disease

    • Stem Cell Biology



    • Collapse Research 
      Collapse Research Activities and Funding
      Integrative functional genomic study of pathways impacted by recurrent autism CNV
      NIH/NIMH R01MH108528Sep 1, 2016 - Jun 30, 2021
      Role: Principal Investigator
      A human neurodevelopmental model for Williams syndrome
      NIH/NIMH R56MH109587Sep 1, 2016 - Aug 31, 2017
      Role: Principal Investigator
      Evaluating the effect of splicing mutations on isoform networks in autism
      NIH/NIMH R01MH109885May 1, 2016 - Feb 28, 2021
      Role: Principal Investigator
      A chimeric brain model to study human neurological diseases
      NIH/NIMH R21MH107771Sep 25, 2015 - Jun 30, 2017
      Role: Principal Investigator
      Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
      NIH/NIMH U19MH107367Sep 21, 2015 - Jun 30, 2020
      Role: Co-Investigator
      Exosome-mediated cell-cell signaling in Rett Syndrome
      NIH/NIMH R01MH103134Sep 26, 2013 - Jul 31, 2017
      Role: Principal Investigator
      Proteogenetics of Autism Spectrum Disorders
      NIH/NIMH R01MH100175Aug 1, 2013 - Mar 31, 2021
      Role: Principal Investigator
      Modeling anorexia nervosa with human pluripotent stem cells
      NIH/NIMH R21MH093954Jan 15, 2012 - Nov 30, 2013
      Role: Principal Investigator
      The Impact of L1retrotransposition in the nervous system
      NIH/NIMH R01MH094753Aug 16, 2011 - May 31, 2016
      Role: Principal Investigator
      Modeling autism with human pluripotent cells
      NIH DP2OD006495Sep 30, 2009 - Jun 30, 2014
      Role: Principal Investigator
      Administrative Core
      NIH/NIMH U19MH-01
      Role: Co-Investigator

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Thomas CA, Tejwani L, Trujillo CA, Negraes PD, Herai RH, Mesci P, Macia A, Crow YJ, Muotri A. Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. Cell Stem Cell. 2017 Aug 02. PMID: 28803918.
        View in: PubMed
      2. Herai RH, Negraes PD, Muotri A. Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA. Hum Mol Genet. 2017 Jul 01; 26(13):2472-2479. PMID: 28430982.
        View in: PubMed
      3. Herai RH, Negraes PD, Muotri A. Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA. Hum Mol Genet. 2017 Jul 01; 26(13):2590. PMID: 28637317.
        View in: PubMed
      4. Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri A, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):E5635-E5644. PMID: 28630288.
        View in: PubMed
      5. Liang N, Trujillo CA, Negraes PD, Muotri A, Lameu C, Ulrich H. Stem cell contributions to neurological disease modeling and personalized medicine. Prog Neuropsychopharmacol Biol Psychiatry. 2017 May 31. PMID: 28576415.
        View in: PubMed
      6. Negraes PD, Cugola FR, Herai RH, Trujillo CA, Cristino AS, Chailangkarn T, Muotri A, Duvvuri V. Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons. Transl Psychiatry. 2017 Mar 14; 7(3):e1060. PMID: 28291261.
        View in: PubMed
      7. Chailangkarn T, Muotri A. Modeling Williams syndrome with induced pluripotent stem cells. Neurogenesis (Austin). 2017; 4(1):e1283187. PMID: 28229087.
        View in: PubMed
      8. Griesi-Oliveira K, Suzuki AM, Muotri A. TRPC Channels and Mental Disorders. Adv Exp Med Biol. 2017; 976:137-148. PMID: 28508319.
        View in: PubMed
      9. de Souza JS, Carromeu C, Torres LB, Araujo BH, Cugola FR, Maciel RM, Muotri A, Giannocco G. IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3. Hum Mol Genet. 2016 Dec 22. PMID: 28007906.
        View in: PubMed
      10. Macia A, Widmann TJ, Heras SR, Ayllon V, Sanchez L, Benkaddour-Boumzaouad M, Munoz-Lopez M, Rubio A, Amador-Cubero S, Blanco-Jimenez E, Garcia-Castro J, Menendez P, Ng P, Muotri A, Goodier JL, Garcia-Perez JL. Engineered LINE-1 retrotransposition in non-dividing human neurons. Genome Res. 2016 Dec 13. PMID: 27965292.
        View in: PubMed
      11. Langley GR, Adcock IM, Busquet F, Crofton KM, Csernok E, Giese C, Heinonen T, Herrmann K, Hofmann-Apitius M, Landesmann B, Marshall LJ, McIvor E, Muotri A, Noor F, Schutte K, Seidle T, van de Stolpe A, Van Esch H, Willett C, Woszczek G. Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations. Drug Discov Today. 2016 Oct 28. PMID: 27989722.
        View in: PubMed
      12. Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri A, Haddad GG. The Na(+)/HCO3(-) co-transporter is protective during ischemia in astrocytes. Neuroscience. 2016 Oct 4. PMID: 27717805.
        View in: PubMed
      13. Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri A, Gage FH. L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2016 Sep 12. PMID: 27618310.
        View in: PubMed
      14. Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri A. A human neurodevelopmental model for Williams syndrome. Nature. 2016 Aug 18; 536(7616):338-43. PMID: 27509850.
        View in: PubMed
      15. Pillat MM, Lameu C, Trujillo CA, Glaser T, Cappellari AR, Negraes PD, Battastini AM, Schwindt TT, Muotri A, Ulrich H. Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation. J Cell Sci. 2016 Sep 15; 129(18):3437-48. PMID: 27528403.
        View in: PubMed
      16. Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria Dde P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PM, Peron JP, Muotri A, Beltrão-Braga PC. The Brazilian Zika virus strain causes birth defects in experimental models. Nature. 2016 Jun 9; 534(7606):267-71. PMID: 27279226.
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      17. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri A, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 7; 98(4):667-79. PMID: 27018473.
        View in: PubMed
      18. Wang Y, Jones-Tabah J, Chakravarty P, Stewart A, Muotri A, Laposa RR, Svejstrup JQ. Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation. Cell Rep. 2016 Mar 22; 14(11):2554-61. PMID: 26972010.
        View in: PubMed
      19. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri A, Almutairi A. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3185-90. PMID: 26944080.
        View in: PubMed
      20. de Melo JT, de Souza Timoteo AR, Lajus TB, Brandão JA, de Souza-Pinto NC, Menck CF, Campalans A, Radicella JP, Vessoni AT, Muotri A, Agnez-Lima LF. XPC deficiency is related to APE1 and OGG1 expression and function. Mutat Res. 2016 Feb-Mar; 784-785:25-33. PMID: 26811994.
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      21. Vessoni AT, Herai RH, Karpiak JV, Leal AM, Trujillo CA, Quinet A, Agnez Lima LF, Menck CF, Muotri A. Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony. Hum Mol Genet. 2016 Apr 1; 25(7):1271-80. PMID: 26755826.
        View in: PubMed
      22. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri A, Marchetto MC, Gage FH, Chen G. KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):751-6. PMID: 26733678.
        View in: PubMed
      23. Muotri A. L1 Retrotransposition in Neural Progenitor Cells. Methods Mol Biol. 2016; 1400:157-63. PMID: 26895053.
        View in: PubMed
      24. Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri A, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 8; 5(6):933-45. PMID: 26610635.
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      25. Langley G, Austin CP, Balapure AK, Birnbaum LS, Bucher JR, Fentem J, Fitzpatrick SC, Fowle JR, Kavlock RJ, Kitano H, Lidbury BA, Muotri A, Peng SQ, Sakharov D, Seidle T, Trez T, Tonevitsky A, van de Stolpe A, Whelan M, Willett C. Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research. Environ Health Perspect. 2015 Nov 1; 123(11):A268-72. PMID: 26523530.
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      26. Moszczynska A, Flack A, Qiu P, Muotri A, Killinger BA. Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain. Sci Rep. 2015; 5:14356. PMID: 26463126.
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      27. Melo US, Macedo-Souza LI, Figueiredo T, Muotri A, Gleeson JG, Coux G, Armas P, Calcaterra NB, Kitajima JP, Amorim S, Olávio TR, Griesi-Oliveira K, Coatti GC, Rocha CR, Martins-Pinheiro M, Menck CF, Zaki MS, Kok F, Zatz M, Santos S. Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome. Hum Mol Genet. 2015 Dec 15; 24(24):6877-85. PMID: 26385635.
        View in: PubMed
      28. Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, Vanderhaeghen P, Verfaillie CM, Raitano S, Kumar A, Carvalho CM, Bagni C, Ramocki MB, Araujo BH, Torres LB, Lupski JR, Van Esch H, Muotri A. Altered neuronal network and rescue in a human MECP2 duplication model. Mol Psychiatry. 2016 Feb; 21(2):178-88. PMID: 26347316.
        View in: PubMed
      29. Acab A, Muotri A. The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment. Neurotherapeutics. 2015 Jul; 12(3):534-45. PMID: 25851569.
        View in: PubMed
      30. Marinho PA, Chailangkarn T, Muotri A. Systematic optimization of human pluripotent stem cells media using Design of Experiments. Sci Rep. 2015; 5:9834. PMID: 25940691.
        View in: PubMed
      31. Muotri A. The Human Model: Changing Focus on Autism Research. Biol Psychiatry. 2016 Apr 15; 79(8):642-9. PMID: 25861701.
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      32. Zhao HW, Gu XQ, Chailangkarn T, Perkins G, Callacondo D, Appenzeller O, Poulsen O, Zhou D, Muotri A, Haddad GG. Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease. Neuroscience. 2015 Mar 12; 288:187-99. PMID: 25559931.
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      33. Griesi-Oliveira K, Acab A, Gupta AR, Sunaga DY, Chailangkarn T, Nicol X, Nunez Y, Walker MF, Murdoch JD, Sanders SJ, Fernandez TV, Ji W, Lifton RP, Vadasz E, Dietrich A, Pradhan D, Song H, Ming GL, Gu X, Haddad G, Marchetto MC, Spitzer N, Passos-Bueno MR, State MW, Muotri A. Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Mol Psychiatry. 2015 Nov; 20(11):1350-65. PMID: 25385366.
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      34. Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri A, Garden GA, La Spada AR. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci. 2014 Sep; 17(9):1180-9. PMID: 25108912.
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      35. Fernandes IR, Russo FB, Pignatari GC, Evangelinellis MM, Tavolari S, Muotri A, Beltrão-Braga PC. Fibroblast sources: Where can we get them? Cytotechnology. 2016 Mar; 68(2):223-8. PMID: 25060709.
        View in: PubMed
      36. Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri A, Gage FH, Kosik KS, Geschwind DH. A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 2014 Jul 2; 83(1):69-86. PMID: 24991955.
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      37. Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M. Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies. J Comp Neurol. 2014 Aug 15; 522(12):2784-801. PMID: 24610493.
        View in: PubMed
      38. Hrvoj-Mihic B, Bienvenu T, Stefanacci L, Muotri A, Semendeferi K. Evolution, development, and plasticity of the human brain: from molecules to bones. Front Hum Neurosci. 2013; 7:707. PMID: 24194709.
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      39. Hrvoj-Mihic B, Marchetto MC, Gage FH, Semendeferi K, Muotri A. Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. Biol Psychiatry. 2014 Jun 15; 75(12):929-35. PMID: 24041506.
        View in: PubMed
      40. Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, Muotri A, Chi NC, Fu XD, Yu BD, Dowdy SF. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 1; 13(2):246-54. PMID: 23910086.
        View in: PubMed
      41. Tang X, Zhou L, Wagner AM, Marchetto MC, Muotri A, Gage FH, Chen G. Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Res. 2013 Sep; 11(2):743-57. PMID: 23759711.
        View in: PubMed
      42. Lovatel GA, Elsner VR, Bertoldi K, Vanzella C, Moysés Fdos S, Vizuete A, Spindler C, Cechinel LR, Netto CA, Muotri A, Siqueira IR. Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus. Neurobiol Learn Mem. 2013 Mar; 101:94-102. PMID: 23357282.
        View in: PubMed
      43. Beltrão-Braga PC, Pignatari GC, Russo FB, Fernandes IR, Muotri A. In-a-dish: induced pluripotent stem cells as a novel model for human diseases. Cytometry A. 2013 Jan; 83(1):11-7. PMID: 23281003.
        View in: PubMed
      44. Elsner VR, Lovatel GA, Moysés F, Bertoldi K, Spindler C, Cechinel LR, Muotri A, Siqueira IR. Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study. Exp Gerontol. 2013 Feb; 48(2):136-9. PMID: 23201423.
        View in: PubMed
      45. Trujillo CA, Negraes PD, Schwindt TT, Lameu C, Carromeu C, Muotri A, Pesquero JB, Cerqueira DM, Pillat MM, de Souza HD, Turaça LT, Abreu JG, Ulrich H. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. J Biol Chem. 2012 Dec 28; 287(53):44046-61. PMID: 23132855.
        View in: PubMed
      46. Freitas BC, Trujillo CA, Carromeu C, Yusupova M, Herai RH, Muotri A. Stem cells and modeling of autism spectrum disorders. Exp Neurol. 2014 Oct; 260:33-43. PMID: 23036599.
        View in: PubMed
      47. Miranda HC, Herai RH, Thomé CH, Gomes GG, Panepucci RA, Orellana MD, Covas DT, Muotri A, Greene LJ, Faça VM. A quantitative proteomic and transcriptomic comparison of human mesenchymal stem cells from bone marrow and umbilical cord vein. Proteomics. 2012 Aug; 12(17):2607-17. PMID: 22778083.
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      48. Chailangkarn T, Acab A, Muotri A. Modeling neurodevelopmental disorders using human neurons. Curr Opin Neurobiol. 2012 Oct; 22(5):785-90. PMID: 22717528.
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      49. Andrade LN, Nathanson JL, Yeo GW, Menck CF, Muotri A. Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome. Hum Mol Genet. 2012 Sep 1; 21(17):3825-34. PMID: 22661500.
        View in: PubMed
      50. Gage FH, Muotri A. What makes each brain unique. Sci Am. 2012 Mar; 306(3):26-31. PMID: 22375319.
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      51. Vessoni AT, Muotri A, Okamoto OK. Autophagy in stem cell maintenance and differentiation. Stem Cells Dev. 2012 Mar 1; 21(4):513-20. PMID: 22066548.
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      52. Thomas CA, Muotri A. LINE-1: creators of neuronal diversity. Front Biosci (Elite Ed). 2012; 4:1663-8. PMID: 22201983.
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      53. Thomas CA, Paquola AC, Muotri A. LINE-1 retrotransposition in the nervous system. Annu Rev Cell Dev Biol. 2012; 28:555-73. PMID: 23057747.
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      54. Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri A, Mu Y, Carson CT, Macia A, Moran JV, Gage FH. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20382-7. PMID: 22159035.
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      55. Ming GL, Brüstle O, Muotri A, Studer L, Wernig M, Christian KM. Cellular reprogramming: recent advances in modeling neurological diseases. J Neurosci. 2011 Nov 9; 31(45):16070-5. PMID: 22072658.
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      56. Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri A, Zatz M. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Hum Mol Genet. 2011 Sep 15; 20(18):3642-52. PMID: 21685205.
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      57. Felfly H, Xue J, Zambon AC, Muotri A, Zhou D, Haddad GG. Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R727-45. PMID: 21677276.
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      58. Beltrão-Braga PC, Pignatari GC, Maiorka PC, Oliveira NA, Lizier NF, Wenceslau CV, Miglino MA, Muotri A, Kerkis I. Feeder-free derivation of induced pluripotent stem cells from human immature dental pulp stem cells. Cell Transplant. 2011; 20(11-12):1707-19. PMID: 21457612.
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      59. Massirer KB, Carromeu C, Griesi-Oliveira K, Muotri A. Maintenance and differentiation of neural stem cells. Wiley Interdiscip Rev Syst Biol Med. 2011 Jan-Feb; 3(1):107-14. PMID: 21061307.
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      60. Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad GG. Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). PMID: 24348887.
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      61. Muotri A, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH. L1 retrotransposition in neurons is modulated by MeCP2. Nature. 2010 Nov 18; 468(7322):443-6. PMID: 21085180.
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      62. Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri A. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12; 143(4):527-39. PMID: 21074045.
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      63. Felfly H, Muotri A, Yao H, Haddad GG. Hematopoietic stem cell transplantation protects mice from lethal stroke. Exp Neurol. 2010 Oct; 225(2):284-93. PMID: 20547154.
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      64. Acu ID, Liu T, Suino-Powell K, Mooney SM, D'Assoro AB, Rowland N, Muotri A, Correa RG, Niu Y, Kumar R, Salisbury JL. Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells. Cancer Res. 2010 Apr 15; 70(8):3320-8. PMID: 20388771.
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      65. Secco M, Moreira YB, Zucconi E, Vieira NM, Jazedje T, Muotri A, Okamoto OK, Verjovski-Almeida S, Zatz M. Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood. Stem Cell Rev. 2009 Dec; 5(4):387-401. PMID: 20058202.
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      66. Muotri A, Zhao C, Marchetto MC, Gage FH. Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus. 2009 Oct; 19(10):1002-7. PMID: 19771587.
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      67. Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri A. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One. 2009; 4(9):e7076. PMID: 19763270.
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      68. Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, Lie DC, Moore L, Nakashima K, Asashima M, Gage FH. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci. 2009 Sep; 12(9):1097-105. PMID: 19701198.
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      69. Marchetto MC, Muotri A, Mu Y, Smith AM, Cezar GG, Gage FH. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 4; 3(6):649-57. PMID: 19041781.
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      70. Muotri A. Modeling epilepsy with pluripotent human cells. Epilepsy Behav. 2009 Jan; 14 Suppl 1:81-5. PMID: 18845273.
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      71. Leite RA, Marchetto MC, Muotri A, Vasconcelos Dde M, de Oliveira ZN, Machado MC, Menck CF. Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes. J Invest Dermatol. 2009 Feb; 129(2):502-6. PMID: 18685619.
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      72. Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri A, Carson C, Gage FH. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75. PMID: 18632700.
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      73. Secco M, Zucconi E, Vieira NM, Fogaça LL, Cerqueira A, Carvalho MD, Jazedje T, Okamoto OK, Muotri A, Zatz M. Mesenchymal stem cells from umbilical cord: do not discard the cord! Neuromuscul Disord. 2008 Jan; 18(1):17-8. PMID: 18155523.
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      74. Cezar GG, Quam JA, Smith AM, Rosa GJ, Piekarczyk MS, Brown JF, Gage FH, Muotri A. Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Dev. 2007 Dec; 16(6):869-82. PMID: 18042039.
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      75. Armelini MG, Lima-Bessa KM, Marchetto MC, Muotri A, Chiganças V, Leite RA, Carvalho H, Menck CF. Exploring DNA damage responses in human cells with recombinant adenoviral vectors. Hum Exp Toxicol. 2007 Nov; 26(11):899-906. PMID: 18042584.
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      76. Muotri A, Marchetto MC, Coufal NG, Gage FH. The necessary junk: new functions for transposable elements. Hum Mol Genet. 2007 Oct 15; 16 Spec No. 2:R159-67. PMID: 17911158.
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      77. Secco M, Zucconi E, Vieira NM, Fogaça LL, Cerqueira A, Carvalho MD, Jazedje T, Okamoto OK, Muotri A, Zatz M. Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells. 2008 Jan; 26(1):146-50. PMID: 17932423.
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      78. Yeo GW, Xu X, Liang TY, Muotri A, Carson CT, Coufal NG, Gage FH. Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol. 2007 Oct; 3(10):1951-67. PMID: 17967047.
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      79. Garcia-Perez JL, Marchetto MC, Muotri A, Coufal NG, Gage FH, O'Shea KS, Moran JV. LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet. 2007 Jul 1; 16(13):1569-77. PMID: 17468180.
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      80. Muotri A, Gage FH. Generation of neuronal variability and complexity. Nature. 2006 Jun 29; 441(7097):1087-93. PMID: 16810244.
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      81. Marchetto MC, Correa RG, Menck CF, Muotri A. Functional lentiviral vectors for xeroderma pigmentosum gene therapy. J Biotechnol. 2006 Dec 1; 126(4):424-30. PMID: 16857285.
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      82. Muotri A, Bottero V, Tergaonkar V, Correa RG. UV-mediated NF-kappaB activation is abolished in deficient XPC/D primary fibroblasts. Cell Cycle. 2006 May; 5(10):1085-9. PMID: 16721051.
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      83. Becker C, Lacchini S, Muotri A, da Silva GJ, Castelli JB, Vassallo PF, Menck CF, Krieger JE. Skeletal muscle cells expressing VEGF induce capillary formation and reduce cardiac injury in rats. Int J Cardiol. 2006 Nov 18; 113(3):348-54. PMID: 16675047.
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      84. Alisch RS, Garcia-Perez JL, Muotri A, Gage FH, Moran JV. Unconventional translation of mammalian LINE-1 retrotransposons. Genes Dev. 2006 Jan 15; 20(2):210-24. PMID: 16418485.
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      85. Cao X, Yeo G, Muotri A, Kuwabara T, Gage FH. Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci. 2006; 29:77-103. PMID: 16776580.
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      86. Muotri A, Nakashima K, Toni N, Sandler VM, Gage FH. Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18644-8. PMID: 16352714.
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      87. Muotri A, Chu VT, Marchetto MC, Deng W, Moran JV, Gage FH. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature. 2005 Jun 16; 435(7044):903-10. PMID: 15959507.
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      88. Lilley CE, Carson CT, Muotri A, Gage FH, Weitzman MD. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5844-9. PMID: 15824307.
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      89. Armelini MG, Muotri A, Marchetto MC, de Lima-Bessa KM, Sarasin A, Menck CF. Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus. Cancer Gene Ther. 2005 Apr; 12(4):389-96. PMID: 15650764.
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      90. Martin MJ, Muotri A, Gage F, Varki A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med. 2005 Feb; 11(2):228-32. PMID: 15685172.
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      91. Marchetto MC, Muotri A, Burns DK, Friedberg EC, Menck CF. Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17759-64. PMID: 15598745.
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      92. Muotri A, Gage FH. Vibrating in the background. Nat Genet. 2003 Nov; 35(3):205-7. PMID: 14593403.
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      93. Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri A, Summers RG, Chun J, Lee KF, Gage FH. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6777-82. PMID: 12748381.
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      94. Muotri A, Marchetto MC, Zerbini LF, Libermann TA, Ventura AM, Sarasin A, Menck CF. Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. Hum Gene Ther. 2002 Oct 10; 13(15):1833-44. PMID: 12396616.
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      95. Muotri A, Marchetto MC, Suzuki MF, Okazaki K, Lotfi CF, Brumatti G, Amarante-Mendes GP, Menck CF. Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance. Carcinogenesis. 2002 Jun; 23(6):1039-46. PMID: 12082027.
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      96. Magalhaes GS, Muotri A, Marchetto MC, Menck CF, Ventura AM. An adenovirus vector containing the suicide gene thymidine kinase for a broad application in cancer gene therapy. Mem Inst Oswaldo Cruz. 2002 Jun; 97(4):547-52. PMID: 12118289.
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      97. Agnez-Lima LF, Napolitano RL, Fuchs RP, Mascio PD, Muotri A, Menck CF. DNA repair and sequence context affect (1)O(2)-induced mutagenesis in bacteria. Nucleic Acids Res. 2001 Jul 1; 29(13):2899-903. PMID: 11433036.
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      98. Chiganças V, Miyaji EN, Muotri A, de Fátima Jacysyn J, Amarante-Mendes GP, Yasui A, Menck CF. Photorepair prevents ultraviolet-induced apoptosis in human cells expressing the marsupial photolyase gene. Cancer Res. 2000 May 1; 60(9):2458-63. PMID: 10811124.
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      99. Muotri A, da Veiga Pereira L, dos Reis Vasques L, Menck CF. Ribozymes and the anti-gene therapy: how a catalytic RNA can be used to inhibit gene function. Gene. 1999 Sep 17; 237(2):303-10. PMID: 10521654.
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