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    Gabriel Silva

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentBioengineering
    Address9500 Gilman Drive #0946
    CA La Jolla 92093
    Phone858-822-4591
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Experimental Testing and Validation of a Quantum Dot FRET Calcium Sensor
      NIH/NIBIB R21EB017898Sep 30, 2013 - Aug 31, 2015
      Role: Principal Investigator
      High Throughput Mapping of Neuronal and Glial Networks
      NIH/NINDS R01NS054736Apr 1, 2006 - Mar 31, 2011
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Uhlirova H, Kiliç K, Tian P, Sakadžic S, Gagnon L, Thunemann M, Desjardins M, Saisan PA, Nizar K, Yaseen MA, Hagler DJ, Vandenberghe M, Djurovic S, Andreassen OA, Silva G, Masliah E, Kleinfeld D, Vinogradov S, Buxton RB, Einevoll GT, Boas DA, Dale AM, Devor A. The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements. Philos Trans R Soc Lond B Biol Sci. 2016 Oct 05; 371(1705). PMID: 27574309; PMCID: PMC5003857 [Available on 10/05/17].
      2. Uhlirova H, Kiliç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžic S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva G, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A. Cell type specificity of neurovascular coupling in cerebral cortex. Elife. 2016 May 31; 5. PMID: 27244241; PMCID: PMC4933561.
      3. Oliveira AV, Silva G, Chung DC. Enhancement of chitosan-mediated gene delivery through combination with phiC31 integrase. Acta Biomater. 2015 Apr; 17:89-97. PMID: 25600399.
        View in: PubMed
      4. Chou Z, Lim J, Brown S, Keller M, Bugbee J, Broccard F, Khraiche ML, Silva G, Cauwenberghs G. Bidirectional neural interface: Closed-loop feedback control for hybrid neural systems. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:3949-52. PMID: 26737158.
        View in: PubMed
      5. Maranhao B, Biswas P, Duncan JL, Branham KE, Silva G, Naeem MA, Khan SN, Riazuddin S, Hejtmancik JF, Heckenlively JR, Riazuddin SA, Lee PL, Ayyagari R. exomeSuite: Whole exome sequence variant filtering tool for rapid identification of putative disease causing SNVs/indels. Genomics. 2014 Feb-Mar; 103(2-3):169-76. PMID: 24603341; PMCID: PMC4146529.
      6. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva G, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. PMID: 24139032; PMCID: PMC3864648.
      7. Macdonald CL, Silva G. A positive feedback cell signaling nucleation model of astrocyte dynamics. Front Neuroeng. 2013; 6:4. PMID: 23847529; PMCID: PMC3706728.
      8. Silva G, Khraiche ML. Nanotechnologies for stimulating and recording excitable events in neurons and cardiomyocytes. Discov Med. 2013 Jun; 15(85):357-65. PMID: 23819950.
        View in: PubMed
      9. Nizar K, Uhlirova H, Tian P, Saisan PA, Cheng Q, Reznichenko L, Weldy KL, Steed TC, Sridhar VB, MacDonald CL, Cui J, Gratiy SL, Sakadzic S, Boas DA, Beka TI, Einevoll GT, Chen J, Masliah E, Dale AM, Silva G, Devor A. In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci. 2013 May 08; 33(19):8411-22. PMID: 23658179; PMCID: PMC3712855.
      10. Khraiche ML, El Emam S, Akinin A, Cauwenberghs G, Freeman W, Silva G. Visual evoked potential characterization of rabbit animal model for retinal prosthesis research. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:3539-42. PMID: 24110493.
        View in: PubMed
      11. Blumling Iii JP, Silva G. Targeting the brain: advances in drug delivery. Curr Pharm Biotechnol. 2012 Sep; 13(12):2417-26. PMID: 23016646.
        View in: PubMed
      12. Ha S, Khraiche ML, Silva G, Cauwenberghs G. Direct inductive stimulation for energy-efficient wireless neural interfaces. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:883-6. PMID: 23366034.
        View in: PubMed
      13. Silva G. The need for the emergence of mathematical neuroscience: beyond computation and simulation. Front Comput Neurosci. 2011; 5:51. PMID: 22131972; PMCID: PMC3223358.
      14. Khraiche ML, Lo Y, Wang D, Cauwenberghs G, Freeman W, Silva G. Ultra-high photosensitivity silicon nanophotonics for retinal prosthesis: electrical characteristics. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:2933-6. PMID: 22254955.
        View in: PubMed
      15. Buibas M, Silva G. A framework for simulating and estimating the state and functional topology of complex dynamic geometric networks. Neural Comput. 2011 Jan; 23(1):183-214. PMID: 20964542.
        View in: PubMed
      16. Silva G. Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system. Ann N Y Acad Sci. 2010 Jun; 1199:221-30. PMID: 20633128.
        View in: PubMed
      17. Buibas M, Yu D, Nizar K, Silva G. Mapping the spatiotemporal dynamics of calcium signaling in cellular neural networks using optical flow. Ann Biomed Eng. 2010 Aug; 38(8):2520-31. PMID: 20300851; PMCID: PMC2900593.
      18. Chow SK, Yu D, Macdonald CL, Buibas M, Silva G. Amyloid ß-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes. ASN Neuro. 2010 Jan 25; 2(1):e00026. PMID: 20001968; PMCID: PMC2810812.
      19. Silva G. Chapter 2 - Quantum dot nanotechnologies for neuroimaging. Prog Brain Res. 2009; 180:19-34. PMID: 20302827.
        View in: PubMed
      20. Pathak S, Tolentino R, Nguyen K, D'Amico L, Barron E, Cheng L, Freeman WR, Silva G. Quantum dot labeling and imaging of glial fibrillary acidic protein intermediate filaments and gliosis in the rat neural retina and dissociated astrocytes. J Nanosci Nanotechnol. 2009 Aug; 9(8):5047-54. PMID: 19928184.
        View in: PubMed
      21. Yu D, Buibas M, Chow SK, Lee IY, Singer Z, Silva G. Characterization of Calcium-Mediated Intracellular and Intercellular Signaling in the rMC-1 Glial Cell Line. Cell Mol Bioeng. 2009 Mar 01; 2(1):144-155. PMID: 19890481.
        View in: PubMed
      22. Silva G. Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS. BMC Neurosci. 2008 Dec 10; 9 Suppl 3:S4. PMID: 19091001; PMCID: PMC2604882.
      23. Macdonald CL, Yu D, Buibas M, Silva G. Diffusion modeling of ATP signaling suggests a partially regenerative mechanism underlies astrocyte intercellular calcium waves. Front Neuroeng. 2008; 1:1. PMID: 18958241; PMCID: PMC2526017.
      24. Falkenstein IA, Cheng L, Wong-Staal F, Tammewar AM, Barron EC, Silva G, Li QX, Yu D, Hysell M, Liu G, Ke N, Macdonald JE, Freeman WR. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul; 33(7):599-609. PMID: 18600493; PMCID: PMC2664073.
      25. Mojana F, Cheng L, Bartsch DU, Silva G, Kozak I, Nigam N, Freeman WR. The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol. 2008 Aug; 146(2):218-227. PMID: 18538742; PMCID: PMC2735863.
      26. Hashemi M, Buibas M, Silva G. Automated detection of intercellular signaling in astrocyte networks using the converging squares algorithm. J Neurosci Methods. 2008 May 30; 170(2):294-9. PMID: 18328570; PMCID: PMC2637820.
      27. Yu D, Silva G. Stem cell sources and therapeutic approaches for central nervous system and neural retinal disorders. Neurosurg Focus. 2008; 24(3-4):E11. PMID: 18341387; PMCID: PMC2647750.
      28. Kozak I, Cheng L, Silva G, Freeman WR. Testing of intraocular drugs for clinical use. Invest Ophthalmol Vis Sci. 2007 Nov; 48(11):4861-3. PMID: 17962431.
        View in: PubMed
      29. Pathak S, Davidson MC, Silva G. Characterization of the functional binding properties of antibody conjugated quantum dots. Nano Lett. 2007 Jul; 7(7):1839-45. PMID: 17536868.
        View in: PubMed
      30. Silva G. What impact will nanotechnology have on neurology? Nat Clin Pract Neurol. 2007 Apr; 3(4):180-1. PMID: 17410106.
        View in: PubMed
      31. Silva G. Nanotechnology approaches for drug and small molecule delivery across the blood brain barrier. Surg Neurol. 2007 Feb; 67(2):113-6. PMID: 17254859.
        View in: PubMed
      32. Kozak I, Kayikcioglu OR, Cheng L, Falkenstein I, Silva G, Yu DX, Freeman WR. The effect of recombinant human hyaluronidase on dexamethasone penetration into the posterior segment of the eye after sub-Tenon's injection. J Ocul Pharmacol Ther. 2006 Oct; 22(5):362-9. PMID: 17076631.
        View in: PubMed
      33. Silva G, Coutinho OP, Ducheyne P, Shapiro IM, Reis RL. The effect of starch and starch-bioactive glass composite microparticles on the adhesion and expression of the osteoblastic phenotype of a bone cell line. Biomaterials. 2007 Jan; 28(2):326-34. PMID: 16876242.
        View in: PubMed
      34. Ho M, Yu D, Davidsion MC, Silva G. Comparison of standard surface chemistries for culturing mesenchymal stem cells prior to neural differentiation. Biomaterials. 2006 Aug; 27(24):4333-9. PMID: 16647114.
        View in: PubMed
      35. Pathak S, Cao E, Davidson MC, Jin S, Silva G. Quantum dot applications to neuroscience: new tools for probing neurons and glia. J Neurosci. 2006 Feb 15; 26(7):1893-5. PMID: 16481420.
        View in: PubMed
      36. Silva G. Neuroscience nanotechnology: progress, opportunities and challenges. Nat Rev Neurosci. 2006 Jan; 7(1):65-74. PMID: 16371951.
        View in: PubMed
      37. Silva G. Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system. Surg Neurol. 2005 Apr; 63(4):301-6. PMID: 15808703.
        View in: PubMed
      38. Silva G. Introduction to nanotechnology and its applications to medicine. Surg Neurol. 2004 Mar; 61(3):216-20. PMID: 14984987.
        View in: PubMed
      39. Silva G, Czeisler C, Niece KL, Beniash E, Harrington DA, Kessler JA, Stupp SI. Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science. 2004 Feb 27; 303(5662):1352-5. PMID: 14739465.
        View in: PubMed
      40. Silva G, Pepperberg DR. Step response of mouse rod photoreceptors modeled in terms of elemental photic signals. IEEE Trans Biomed Eng. 2004 Jan; 51(1):3-12. PMID: 14723488.
        View in: PubMed
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