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David Traver

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Phone858-822-4593
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of macrophages during hematopoietic stem cell emergence
    NIH/NIAID R21AI137575Nov 19, 2018 - Oct 31, 2020
    Role: Principal Investigator
    An integrative cellular blueprint of vertebrate tissue development
    NIH R01OD026219Sep 15, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Wnt signaling in hematopoietic development
    NIH/NHLBI R01HL135205Jan 1, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Lineage tracing the embryonic origins of tissue-resident macrophages
    NIH/NIAID R21AI124179Jun 17, 2016 - May 31, 2018
    Role: Principal Investigator
    FGF signaling in the specification and emergence of hematopoietic stem cells
    NIH/NHLBI R01HL119056Aug 1, 2014 - Apr 30, 2018
    Role: Principal Investigator
    Ontogeny and function of zebrafish antigen presenting cells
    NIH/NIAID R56AI079287Aug 15, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Molecular and functional dissection of the zebrafish hematopoietic stem cell niche
    NIH/NIDDK R01DK074482May 8, 2006 - Jul 31, 2020
    Role: Principal Investigator
    Study of hematopoietic stem cells in zebrafish
    NIH/NIDDK K01DK066254Feb 15, 2004 - Dec 31, 2008
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kobayashi I, Kondo M, Yamamori S, Kobayashi-Sun J, Taniguchi M, Kanemaru K, Katakura F, Traver D. Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney. Sci Rep. 2019 Oct 02; 9(1):14205. PMID: 31578390.
      View in: PubMed
    2. Hong S, Sahai-Hernandez P, Chapla DG, Moremen KW, Traver D, Wu P. Direct Visualization of Live Zebrafish Glycans via Single-Step Metabolic Labeling with Fluorophore-Tagged Nucleotide Sugars. Angew Chem Int Ed Engl. 2019 Oct 01; 58(40):14327-14333. PMID: 31295389.
      View in: PubMed
    3. Grainger S, Nguyen N, Richter J, Setayesh J, Lonquich B, Oon CH, Wozniak JM, Barahona R, Kamei CN, Houston J, Carrillo-Terrazas M, Drummond IA, Gonzalez D, Willert K, Traver D. EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nat Cell Biol. 2019 06; 21(6):721-730. PMID: 31110287.
      View in: PubMed
    4. Grainger S, Traver D. Embryonic Immune Cells Remodel the Heart. Dev Cell. 2019 03 11; 48(5):595-596. PMID: 30861372.
      View in: PubMed
    5. Gu Q, Yang X, Lv J, Zhang J, Xia B, Kim JD, Wang R, Xiong F, Meng S, Clements TP, Tandon B, Wagner DS, Diaz MF, Wenzel PL, Miller YI, Traver D, Cooke JP, Li W, Zon LI, Chen K, Bai Y, Fang L. AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019 03 08; 363(6431):1085-1088. PMID: 30705153.
      View in: PubMed
    6. Weijts B, Gutierrez E, Saikin SK, Ablooglu AJ, Traver D, Groisman A, Tkachenko E. Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. Nat Commun. 2018 12 14; 9(1):5314. PMID: 30552331.
      View in: PubMed
    7. Bickers C, Española SD, Grainger S, Pouget C, Traver D. Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. PLoS One. 2018; 13(9):e0202747. PMID: 30208064.
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    8. Ferrero G, Mahony CB, Dupuis E, Yvernogeau L, Di Ruggiero E, Miserocchi M, Caron M, Robin C, Traver D, Bertrand JY, Wittamer V. Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish. Cell Rep. 2018 07 03; 24(1):130-141. PMID: 29972775.
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    9. Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana TM, Traver D, Miller YI. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun. 2018 04 03; 9(1):1310. PMID: 29615667.
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    10. Richter J, Stanley EG, Ng ES, Elefanty AG, Traver D, Willert K. WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development. Genes (Basel). 2018 Jan 29; 9(2). PMID: 29382179.
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    11. Grainger S, Traver D, Willert K. Wnt Signaling in Hematological Malignancies. Prog Mol Biol Transl Sci. 2018 01; 153:321-341. PMID: 29389522.
      View in: PubMed
    12. van der Vaart M, Svoboda O, Weijts BG, Espín-Palazón R, Sapp V, Pietri T, Bagnat M, Muotri AR, Traver D. Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. Dis Model Mech. 2017 12 19; 10(12):1439-1451. PMID: 28993314.
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    13. Espin-Palazon R, Weijts B, Mulero V, Traver D. Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence. Trends Cell Biol. 2018 01; 28(1):58-66. PMID: 28882414.
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    14. Richter J, Traver D, Willert K. The role of Wnt signaling in hematopoietic stem cell development. Crit Rev Biochem Mol Biol. 2017 08; 52(4):414-424. PMID: 28508727.
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    15. Keightley MC, Carradice DP, Layton JE, Pase L, Bertrand JY, Wittig JG, Dakic A, Badrock AP, Cole NJ, Traver D, Nutt SL, McCoey J, Buckle AM, Heath JK, Lieschke GJ. The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Nat Commun. 2017 04 06; 8:14911. PMID: 28382966.
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    16. Wolf A, Aggio J, Campbell C, Wright F, Marquez G, Traver D, Stachura DL. Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. Sci Rep. 2017 03 16; 7:44644. PMID: 28300168.
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    17. Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L. Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 01 31; 19(2):142. PMID: 28139650.
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    18. Weijts B, Tkachenko E, Traver D, Groisman A. A Four-Well Dish for High-Resolution Longitudinal Imaging of the Tail and Posterior Trunk of Larval Zebrafish. Zebrafish. 2017 10; 14(5):489-491. PMID: 28118101.
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    19. Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çaglayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464. PMID: 28092684.
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    20. Boyle G, Richter K, Priest HD, Traver D, Mockler TC, Chang JT, Kay SA, Breton G. Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes. PLoS One. 2017; 12(1):e0169923. PMID: 28076377.
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    21. Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L. Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 Jan; 19(1):17-27. PMID: 27870830.
      View in: PubMed
    22. Grainger S, Lonquich B, Oon CH, Nguyen N, Willert K, Traver D. CRISPR Guide RNA Validation In Vitro. Zebrafish. 2017 08; 14(4):383-386. PMID: 27829120.
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    23. Li RA, Traver D, Matthes T, Bertrand JY. Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish. Blood. 2016 12 29; 128(26):3052-3060. PMID: 27827822.
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    24. Grainger S, Richter J, Palazón RE, Pouget C, Lonquich B, Wirth S, Grassme KS, Herzog W, Swift MR, Weinstein BM, Traver D, Willert K. Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Rep. 2016 11 01; 17(6):1595-1606. PMID: 27806298.
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    25. Kim JH, Shinde DN, Reijnders MRF, Hauser NS, Belmonte RL, Wilson GR, Bosch DGM, Bubulya PA, Shashi V, Petrovski S, Stone JK, Park EY, Veltman JA, Sinnema M, Stumpel CTRM, Draaisma JM, Nicolai J, Yntema HG, Lindstrom K, de Vries BBA, Jewett T, Santoro SL, Vogt J, Bachman KK, Seeley AH, Krokosky A, Turner C, Rohena L, Hempel M, Kortüm F, Lessel D, Neu A, Strom TM, Wieczorek D, Bramswig N, Laccone FA, Behunova J, Rehder H, Gordon CT, Rio M, Romana S, Tang S, El-Khechen D, Cho MT, McWalter K, Douglas G, Baskin B, Begtrup A, Funari T, Schoch K, Stegmann APA, Stevens SJC, Zhang DE, Traver D, Yao X, MacArthur DG, Brunner HG, Mancini GM, Myers RM, Owen LB, Lim ST, Stachura DL, Vissers LELM, Ahn EYE. De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome. Am J Hum Genet. 2016 09 01; 99(3):711-719. PMID: 27545680.
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    26. Svoboda O, Stachura DL, Machonova O, Zon LI, Traver D, Bartunek P. Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nat Protoc. 2016 May; 11(5):1007-20. PMID: 27123951.
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    27. Espín-Palazón R, Traver D. The NF-?B family: Key players during embryonic development and HSC emergence. Exp Hematol. 2016 07; 44(7):519-27. PMID: 27132652.
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    28. Sertori R, Liongue C, Basheer F, Lewis KL, Rasighaemi P, de Coninck D, Traver D, Ward AC. Conserved IL-2R?c Signaling Mediates Lymphopoiesis in Zebrafish. J Immunol. 2016 Jan 01; 196(1):135-43. PMID: 26590317.
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    29. Butko E, Pouget C, Traver D. Complex regulation of HSC emergence by the Notch signaling pathway. Dev Biol. 2016 Jan 01; 409(1):129-138. PMID: 26586199.
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    30. Campbell C, Su T, Lau RP, Shah A, Laurie PC, Avalos B, Aggio J, Harris E, Traver D, Stachura DL. Zebrafish embryonic stromal trunk (ZEST) cells support hematopoietic stem and progenitor cell (HSPC) proliferation, survival, and differentiation. Exp Hematol. 2015 Dec; 43(12):1047-61. PMID: 26391449.
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    31. Kim BJ, Hancock BM, Bermudez A, Del Cid N, Reyes E, van Sorge NM, Lauth X, Smurthwaite CA, Hilton BJ, Stotland A, Banerjee A, Buchanan J, Wolkowicz R, Traver D, Doran KS. Bacterial induction of Snail1 contributes to blood-brain barrier disruption. J Clin Invest. 2015 Jun; 125(6):2473-83. PMID: 25961453.
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    32. Traver D. Going with the flow: how shear stress signals the emergence of adult hematopoiesis. J Exp Med. 2015 May 04; 212(5):600. PMID: 25941320.
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    33. Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Espín-Palazón R, Lawson ND, Dorsky R, Clements WK, Traver D. Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development. 2015 Mar 15; 142(6):1050-61. PMID: 25758220.
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    34. Sahai-Hernandez P, Traver D. Intimacy of the niche: perivascular remodeling cuddles incoming HSCs. Cell Stem Cell. 2015 Feb 05; 16(2):109-10. PMID: 25658365.
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    35. Kim BJ, Hancock BM, Del Cid N, Bermudez A, Traver D, Doran KS. Streptococcus agalactiae infection in zebrafish larvae. Microb Pathog. 2015 Feb; 79:57-60. PMID: 25617657.
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    36. Kim AD, Stachura DL, Traver D. Cell signaling pathways involved in hematopoietic stem cell specification. Exp Cell Res. 2014 Dec 10; 329(2):227-33. PMID: 25447318.
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    37. Lee Y, Manegold JE, Kim AD, Pouget C, Stachura DL, Clements WK, Traver D. FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun. 2014 Nov 27; 5:5583. PMID: 25428693.
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    38. Pouget C, Peterkin T, Simões FC, Lee Y, Traver D, Patient R. FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway. Nat Commun. 2014 Nov 27; 5:5588. PMID: 25429520.
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    39. Espín-Palazón R, Stachura DL, Campbell CA, García-Moreno D, Del Cid N, Kim AD, Candel S, Meseguer J, Mulero V, Traver D. Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014 Nov 20; 159(5):1070-1085. PMID: 25416946.
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    40. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Mork LA, Crump JG, Traver D. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73. PMID: 25230933.
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    41. Ouyang K, Leandro Gomez-Amaro R, Stachura DL, Tang H, Peng X, Fang X, Traver D, Evans SM, Chen J. Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12; 5:4814. PMID: 25215520.
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    42. Stachura DL, Traver D. Hematopoietic ontogeny in the axolotl. Blood. 2014 Aug 21; 124(8):1204-6. PMID: 25147373.
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    43. Kobayashi I, Kobayashi-Sun J, Kim AD, Pouget C, Fujita N, Suda T, Traver D. Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 2014 Aug 21; 512(7514):319-23. PMID: 25119047.
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    44. Charbord P, Pouget C, Binder H, Dumont F, Stik G, Levy P, Allain F, Marchal C, Richter J, Uzan B, Pflumio F, Letourneur F, Wirth H, Dzierzak E, Traver D, Jaffredo T, Durand C. A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche. Cell Stem Cell. 2014 Sep 04; 15(3):376-391. PMID: 25042701.
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    45. Svoboda O, Stachura DL, Machonová O, Pajer P, Brynda J, Zon LI, Traver D, Bartunek P. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014 Jul 10; 124(2):220-8. PMID: 24869937.
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    46. Lewis KL, Del Cid N, Traver D. Perspectives on antigen presenting cells in zebrafish. Dev Comp Immunol. 2014 Sep; 46(1):63-73. PMID: 24685511.
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    47. Stachura DL, Svoboda O, Campbell CA, Espín-Palazón R, Lau RP, Zon LI, Bartunek P, Traver D. The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013 Dec 05; 122(24):3918-28. PMID: 24128862.
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    48. Page DM, Wittamer V, Bertrand JY, Lewis KL, Pratt DN, Delgado N, Schale SE, McGue C, Jacobsen BH, Doty A, Pao Y, Yang H, Chi NC, Magor BG, Traver D. An evolutionarily conserved program of B-cell development and activation in zebrafish. Blood. 2013 Aug 22; 122(8):e1-11. PMID: 23861249.
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    49. Clements WK, Traver D. Signalling pathways that control vertebrate haematopoietic stem cell specification. Nat Rev Immunol. 2013 May; 13(5):336-48. PMID: 23618830.
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    50. Shah RN, Rodriguez-Nunez I, Eason DD, Haire RN, Bertrand JY, Wittamer V, Traver D, Nordone SK, Litman GW, Yoder JA. Development and characterization of anti-nitr9 antibodies. Adv Hematol. 2012; 2012:596925. PMID: 23049557.
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    51. Clements WK, Traver D. Fish pharming: zebrafish antileukemia screening. Blood. 2012 Jun 14; 119(24):5614-5. PMID: 22700692.
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    52. Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, Barth CJ, Lugo G, Donnelly M, Nayer A, Moita LF, Schürer S, Traver D, Ruiz P, Vazquez-Padron RI, Ley K, Reiser J, Gupta V. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal. 2011 Sep 06; 4(189):ra57. PMID: 21900205.
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    53. Clements WK, Kim AD, Ong KG, Moore JC, Lawson ND, Traver D. A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 2011 Jun 08; 474(7350):220-4. PMID: 21654806.
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    54. Stachura DL, Svoboda O, Lau RP, Balla KM, Zon LI, Bartunek P, Traver D. Clonal analysis of hematopoietic progenitor cells in the zebrafish. Blood. 2011 Aug 04; 118(5):1274-82. PMID: 21415264.
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    55. Wittamer V, Bertrand JY, Gutschow PW, Traver D. Characterization of the mononuclear phagocyte system in zebrafish. Blood. 2011 Jun 30; 117(26):7126-35. PMID: 21406720.
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    56. Stachura DL, Traver D. Cellular dissection of zebrafish hematopoiesis. Methods Cell Biol. 2011; 101:75-110. PMID: 21550440.
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    57. Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase. PLoS Biol. 2010 Dec 14; 8(12):e1000559. PMID: 21179498.
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    58. Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66. PMID: 20951945.
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    59. Lugo-Villarino G, Balla KM, Stachura DL, Bañuelos K, Werneck MB, Traver D. Identification of dendritic antigen-presenting cells in the zebrafish. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15850-5. PMID: 20733076.
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    60. Balla KM, Lugo-Villarino G, Spitsbergen JM, Stachura DL, Hu Y, Bañuelos K, Romo-Fewell O, Aroian RV, Traver D. Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010 Nov 11; 116(19):3944-54. PMID: 20713961.
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    61. Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature. 2010 Mar 04; 464(7285):108-11. PMID: 20154733.
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    62. Bertrand JY, Cisson JL, Stachura DL, Traver D. Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo. Blood. 2010 Apr 08; 115(14):2777-83. PMID: 20107232.
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    63. Yoder JA, Turner PM, Wright PD, Wittamer V, Bertrand JY, Traver D, Litman GW. Developmental and tissue-specific expression of NITRs. Immunogenetics. 2010 Feb; 62(2):117-22. PMID: 20012603.
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    64. Amigo JD, Ackermann GE, Cope JJ, Yu M, Cooney JD, Ma D, Langer NB, Shafizadeh E, Shaw GC, Horsely W, Trede NS, Davidson AJ, Barut BA, Zhou Y, Wojiski SA, Traver D, Moran TB, Kourkoulis G, Hsu K, Kanki JP, Shah DI, Lin HF, Handin RI, Cantor AB, Paw BH. The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 2009 Nov 19; 114(21):4654-63. PMID: 19729519.
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    65. Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, Traver D, van Rooijen N, Weissman IL. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009 Jul 23; 138(2):271-85. PMID: 19632178.
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    66. Bertrand JY, Traver D. Hematopoietic cell development in the zebrafish embryo. Curr Opin Hematol. 2009 Jul; 16(4):243-8. PMID: 19491671.
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    67. Clements WK, Ong KG, Traver D. Zebrafish wnt3 is expressed in developing neural tissue. Dev Dyn. 2009 Jul; 238(7):1788-95. PMID: 19452545.
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    68. Stachura DL, Reyes JR, Bartunek P, Paw BH, Zon LI, Traver D. Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood. 2009 Jul 09; 114(2):279-89. PMID: 19433857.
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    69. Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent S, Attié-Bitach T, Holden KR, Dobyns WB, Traver D, Al-Gazali L, Ali BR, Lindner TH, Caspary T, Otto EA, Hildebrandt F, Glass IA, Logan CV, Johnson CA, Bennett C, Brancati F, Valente EM, Woods CG, Gleeson JG. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet. 2008 Aug; 83(2):170-9. PMID: 18674751.
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    70. Bertrand JY, Kim AD, Teng S, Traver D. CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development. 2008 May; 135(10):1853-62. PMID: 18417622.
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    71. Bertrand JY, Kim AD, Violette EP, Stachura DL, Cisson JL, Traver D. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development. 2007 Dec; 134(23):4147-56. PMID: 17959717.
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    72. Wei S, Zhou JM, Chen X, Shah RN, Liu J, Orcutt TM, Traver D, Djeu JY, Litman GW, Yoder JA. The zebrafish activating immune receptor Nitr9 signals via Dap12. Immunogenetics. 2007 Oct; 59(10):813-21. PMID: 17891481.
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    73. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. PMID: 17626277.
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    74. Yoder JA, Orcutt TM, Traver D, Litman GW. Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors. Gene. 2007 Oct 15; 401(1-2):154-64. PMID: 17719728.
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    75. Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, Brownlie A, Balzan R, Weiss MJ, Peters LL, Kaplan J, Zon LI, Paw BH. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006 Mar 02; 440(7080):96-100. PMID: 16511496.
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    76. Panagos PG, Dobrinski KP, Chen X, Grant AW, Traver D, Djeu JY, Wei S, Yoder JA. Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish. Immunogenetics. 2006 Feb; 58(1):31-40. PMID: 16467987.
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    77. Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 2005 Oct 01; 19(19):2331-42. PMID: 16166372.
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    78. Lin HF, Traver D, Zhu H, Dooley K, Paw BH, Zon LI, Handin RI. Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood. 2005 Dec 01; 106(12):3803-10. PMID: 16099879.
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    79. Zhu H, Traver D, Davidson AJ, Dibiase A, Thisse C, Thisse B, Nimer S, Zon LI. Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish. Dev Biol. 2005 May 15; 281(2):256-69. PMID: 15893977.
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    80. Fraenkel PG, Traver D, Donovan A, Zahrieh D, Zon LI. Ferroportin1 is required for normal iron cycling in zebrafish. J Clin Invest. 2005 Jun; 115(6):1532-41. PMID: 15902304.
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    81. Akashi K, Traver D, Zon LI. The complex cartography of stem cell commitment. Cell. 2005 Apr 22; 121(2):160-2. PMID: 15851023.
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    82. Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005 Feb 08; 15(3):249-54. PMID: 15694309.
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    83. Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004 Aug; 2(8):E237. PMID: 15314655.
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    84. Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N, Akashi K. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity. 2004 Jul; 21(1):43-53. PMID: 15345219.
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    85. Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI. Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood. 2004 Sep 01; 104(5):1298-305. PMID: 15142873.
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    86. Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7369-74. PMID: 15123839.
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    87. Trede NS, Langenau DM, Traver D, Look AT, Zon LI. The use of zebrafish to understand immunity. Immunity. 2004 Apr; 20(4):367-79. PMID: 15084267.
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    88. Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, Paw BH, Rhodes J, Berman JN, Zon LI, Kanki JP, Look AT. The pu.1 promoter drives myeloid gene expression in zebrafish. Blood. 2004 Sep 01; 104(5):1291-7. PMID: 14996705.
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    89. Traver D, Akashi K. Lineage commitment and developmental plasticity in early lymphoid progenitor subsets. Adv Immunol. 2004; 83:1-54. PMID: 15135627.
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    90. Traver D. Cellular dissection of zebrafish hematopoiesis. Methods Cell Biol. 2004; 76:127-49. PMID: 15602875.
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    91. Traver D, Paw BH, Poss KD, Penberthy WT, Lin S, Zon LI. Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol. 2003 Dec; 4(12):1238-46. PMID: 14608381.
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    92. Jaiswal S, Traver D, Miyamoto T, Akashi K, Lagasse E, Weissman IL. Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10002-7. PMID: 12890867.
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    93. Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT. Myc-induced T cell leukemia in transgenic zebrafish. Science. 2003 Feb 07; 299(5608):887-90. PMID: 12574629.
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    94. Traver D, Herbomel P, Patton EE, Murphey RD, Yoder JA, Litman GW, Catic A, Amemiya CT, Zon LI, Trede NS. The zebrafish as a model organism to study development of the immune system. Adv Immunol. 2003; 81:253-330. PMID: 14711058.
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    95. Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003 Jan 15; 101(2):508-16. PMID: 12393529.
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    96. BitMansour A, Burns SM, Traver D, Akashi K, Contag CH, Weissman IL, Brown JM. Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. Blood. 2002 Dec 15; 100(13):4660-7. PMID: 12393415.
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    97. Na Nakorn T, Traver D, Weissman IL, Akashi K. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J Clin Invest. 2002 Jun; 109(12):1579-85. PMID: 12070305.
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    98. Traver D, Zon LI. Walking the walk: migration and other common themes in blood and vascular development. Cell. 2002 Mar 22; 108(6):731-4. PMID: 11955426.
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