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David Traver

Title(s)Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    The role of macrophages during hematopoietic stem cell emergence
    NIH R21AI137575Nov 19, 2018 - Oct 31, 2020
    Role: Principal Investigator
    An integrative cellular blueprint of vertebrate tissue development
    NIH R01OD026219Sep 15, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Wnt signaling in hematopoietic development
    NIH R01HL135205Jan 1, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Lineage tracing the embryonic origins of tissue-resident macrophages
    NIH R21AI124179Jun 17, 2016 - May 31, 2018
    Role: Principal Investigator
    FGF signaling in the specification and emergence of hematopoietic stem cells
    NIH R01HL119056Aug 1, 2014 - Apr 30, 2018
    Role: Principal Investigator
    Ontogeny and function of zebrafish antigen presenting cells
    NIH R56AI079287Aug 15, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Molecular and functional dissection of the zebrafish hematopoietic stem cell niche
    NIH R01DK074482Jan 18, 2010 - Dec 31, 2010
    Role: Principal Investigator
    Study of hematopoietic stem cells in zebrafish
    NIH K01DK066254Feb 15, 2004 - Dec 31, 2008
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050May 15, 1997 - Dec 11, 1993
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Nat Cell Biol. 2020 12; 22(12):1411-1422. Espanola SG, Song H, Ryu E, Saxena A, Kim ES, Manegold JE, Nasamran CA, Sahoo D, Oh CK, Bickers C, Shin U, Grainger S, Park YH, Pandolfo L, Kang MS, Kang S, Myung K, Cooper KL, Yelon D, Traver D, Lee Y. PMID: 33230303.
      View in: PubMed   Mentions:    Fields:    
    2. EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nat Cell Biol. 2019 06; 21(6):721-730. Grainger S, Nguyen N, Richter J, Setayesh J, Lonquich B, Oon CH, Wozniak JM, Barahona R, Kamei CN, Houston J, Carrillo-Terrazas M, Drummond IA, Gonzalez D, Willert K, Traver D. PMID: 31110287.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Embryonic Immune Cells Remodel the Heart. Dev Cell. 2019 03 11; 48(5):595-596. Grainger S, Traver D. PMID: 30861372.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. Nat Commun. 2018 12 14; 9(1):5314. Weijts B, Gutierrez E, Saikin SK, Ablooglu AJ, Traver D, Groisman A, Tkachenko E. PMID: 30552331.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    5. Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. PLoS One. 2018; 13(9):e0202747. Bickers C, Española SD, Grainger S, Pouget C, Traver D. PMID: 30208064.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun. 2018 04 03; 9(1):1310. PMID: 29615667.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development. Genes (Basel). 2018 Jan 29; 9(2). Richter J, Stanley EG, Ng ES, Elefanty AG, Traver D, Willert K. PMID: 29382179.
      View in: PubMed   Mentions: 3     Fields:    
    8. Wnt Signaling in Hematological Malignancies. Prog Mol Biol Transl Sci. 2018 01; 153:321-341. PMID: 29389522.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    9. Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. Dis Model Mech. 2017 12 19; 10(12):1439-1451. PMID: 28993314.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence. Trends Cell Biol. 2018 01; 28(1):58-66. Espin-Palazon R, Weijts B, Mulero V, Traver D. PMID: 28882414.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. The role of Wnt signaling in hematopoietic stem cell development. Crit Rev Biochem Mol Biol. 2017 08; 52(4):414-424. PMID: 28508727.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464. PMID: 28092684.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    13. CRISPR Guide RNA Validation In Vitro. Zebrafish. 2017 08; 14(4):383-386. PMID: 27829120.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Rep. 2016 11 01; 17(6):1595-1606. PMID: 27806298.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. The NF-κB family: Key players during embryonic development and HSC emergence. Exp Hematol. 2016 07; 44(7):519-27. Espín-Palazón R, Traver D. PMID: 27132652.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Complex regulation of HSC emergence by the Notch signaling pathway. Dev Biol. 2016 Jan 01; 409(1):129-138. PMID: 26586199.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    17. Zebrafish embryonic stromal trunk (ZEST) cells support hematopoietic stem and progenitor cell (HSPC) proliferation, survival, and differentiation. Exp Hematol. 2015 Dec; 43(12):1047-61. PMID: 26391449.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. Going with the flow: how shear stress signals the emergence of adult hematopoiesis. J Exp Med. 2015 May 04; 212(5):600. PMID: 25941320.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development. 2015 Mar 15; 142(6):1050-61. PMID: 25758220.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    20. Intimacy of the niche: perivascular remodeling cuddles incoming HSCs. Cell Stem Cell. 2015 Feb 05; 16(2):109-10. PMID: 25658365.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun. 2014 Nov 27; 5:5583. PMID: 25428693.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    22. FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway. Nat Commun. 2014 Nov 27; 5:5588. PMID: 25429520.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    23. Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014 Nov 20; 159(5):1070-1085. PMID: 25416946.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    24. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73. PMID: 25230933.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    25. Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12; 5:4814. PMID: 25215520.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    26. Hematopoietic ontogeny in the axolotl. Blood. 2014 Aug 21; 124(8):1204-6. PMID: 25147373.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    27. Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 2014 Aug 21; 512(7514):319-23. PMID: 25119047.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    28. Perspectives on antigen presenting cells in zebrafish. Dev Comp Immunol. 2014 Sep; 46(1):63-73. PMID: 24685511.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    29. The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013 Dec 05; 122(24):3918-28. PMID: 24128862.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    30. Fish pharming: zebrafish antileukemia screening. Blood. 2012 Jun 14; 119(24):5614-5. PMID: 22700692.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    31. A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 2011 Jun 08; 474(7350):220-4. Clements WK, Kim AD, Ong KG, Moore JC, Lawson ND, Traver D. PMID: 21654806.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    32. Clonal analysis of hematopoietic progenitor cells in the zebrafish. Blood. 2011 Aug 04; 118(5):1274-82. Stachura DL, Svoboda O, Lau RP, Balla KM, Zon LI, Bartunek P, Traver D. PMID: 21415264.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    33. Characterization of the mononuclear phagocyte system in zebrafish. Blood. 2011 Jun 30; 117(26):7126-35. PMID: 21406720.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    34. Cellular dissection of zebrafish hematopoiesis. Methods Cell Biol. 2011; 101:75-110. PMID: 21550440.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    35. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase. PLoS Biol. 2010 Dec 14; 8(12):e1000559. Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. PMID: 21179498.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    36. Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010 Nov 11; 116(19):3944-54. Balla KM, Lugo-Villarino G, Spitsbergen JM, Stachura DL, Hu Y, Bañuelos K, Romo-Fewell O, Aroian RV, Traver D. PMID: 20713961.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    37. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature. 2010 Mar 04; 464(7285):108-11. Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D. PMID: 20154733.
      View in: PubMed   Mentions: 346     Fields:    Translation:AnimalsCells
    38. Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo. Blood. 2010 Apr 08; 115(14):2777-83. Bertrand JY, Cisson JL, Stachura DL, Traver D. PMID: 20107232.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    39. Zebrafish wnt3 is expressed in developing neural tissue. Dev Dyn. 2009 Jul; 238(7):1788-95. Clements WK, Ong KG, Traver D. PMID: 19452545.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    40. Hematopoietic cell development in the zebrafish embryo. Curr Opin Hematol. 2009 Jul; 16(4):243-8. Bertrand JY, Traver D. PMID: 19491671.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    41. Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood. 2009 Jul 09; 114(2):279-89. Stachura DL, Reyes JR, Bartunek P, Paw BH, Zon LI, Traver D. PMID: 19433857.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    42. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet. 2008 Aug; 83(2):170-9. Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent S, Attié-Bitach T, Holden KR, Dobyns WB, Traver D, Al-Gazali L, Ali BR, Lindner TH, Caspary T, Otto EA, Hildebrandt F, Glass IA, Logan CV, Johnson CA, Bennett C, Brancati F, Valente EM, Woods CG, Gleeson JG. PMID: 18674751.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    43. CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development. 2008 May; 135(10):1853-62. Bertrand JY, Kim AD, Teng S, Traver D. PMID: 18417622.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    44. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development. 2007 Dec; 134(23):4147-56. Bertrand JY, Kim AD, Violette EP, Stachura DL, Cisson JL, Traver D. PMID: 17959717.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    45. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ. PMID: 17626277.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    46. Cellular dissection of zebrafish hematopoiesis. Methods Cell Biol. 2004; 76:127-49. Traver D. PMID: 15602875.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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