David Traver

Title(s)Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    The role of macrophages during hematopoietic stem cell emergence
    NIH R21AI137575Nov 19, 2018 - Oct 31, 2020
    Role: Principal Investigator
    An integrative cellular blueprint of vertebrate tissue development
    NIH R01OD026219Sep 15, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Wnt signaling in hematopoietic development
    NIH R01HL135205Jan 1, 2017 - Jun 30, 2025
    Role: Principal Investigator
    Lineage tracing the embryonic origins of tissue-resident macrophages
    NIH R21AI124179Jun 17, 2016 - May 31, 2018
    Role: Principal Investigator
    FGF signaling in the specification and emergence of hematopoietic stem cells
    NIH R01HL119056Aug 1, 2014 - Apr 30, 2018
    Role: Principal Investigator
    Ontogeny and function of zebrafish antigen presenting cells
    NIH R56AI079287Aug 15, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Molecular and functional dissection of the zebrafish hematopoietic stem cell niche
    NIH R01DK074482May 8, 2006 - Nov 30, 2024
    Role: Principal Investigator
    Study of hematopoietic stem cells in zebrafish
    NIH K01DK066254Feb 15, 2004 - Dec 31, 2008
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. Elife. 2023 09 11; 12. Sahai-Hernandez P, Pouget C, Eyal S, Svoboda O, Chacon J, Grimm L, Gjøen T, Traver D. PMID: 37695317; PMCID: PMC10495111.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    2. Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency. N Engl J Med. 2023 Aug 10; 389(6):527-539. Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antón J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L, Boztug K. PMID: 37342957.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    3. Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B. J Clin Invest. 2023 06 01; 133(11). Azad P, Zhou D, Tu HC, Villafuerte FC, Traver D, Rana TM, Haddad GG. PMID: 37022795; PMCID: PMC10231995.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    4. Endothelial struts enable the generation of large lumenized blood vessels de novo. Nat Cell Biol. 2021 04; 23(4):322-329. Weijts B, Shaked I, Ginsberg M, Kleinfeld D, Robin C, Traver D. PMID: 33837285; PMCID: PMC8500358.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Nat Cell Biol. 2020 12; 22(12):1411-1422. Espanola SG, Song H, Ryu E, Saxena A, Kim ES, Manegold JE, Nasamran CA, Sahoo D, Oh CK, Bickers C, Shin U, Grainger S, Park YH, Pandolfo L, Kang MS, Kang S, Myung K, Cooper KL, Yelon D, Traver D, Lee Y. PMID: 33230303; PMCID: PMC8092813.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    6. EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nat Cell Biol. 2019 06; 21(6):721-730. Grainger S, Nguyen N, Richter J, Setayesh J, Lonquich B, Oon CH, Wozniak JM, Barahona R, Kamei CN, Houston J, Carrillo-Terrazas M, Drummond IA, Gonzalez D, Willert K, Traver D. PMID: 31110287; PMCID: PMC6559346.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    7. Embryonic Immune Cells Remodel the Heart. Dev Cell. 2019 03 11; 48(5):595-596. Grainger S, Traver D. PMID: 30861372.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. Nat Commun. 2018 12 14; 9(1):5314. Weijts B, Gutierrez E, Saikin SK, Ablooglu AJ, Traver D, Groisman A, Tkachenko E. PMID: 30552331; PMCID: PMC6294260.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    9. Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. PLoS One. 2018; 13(9):e0202747. Bickers C, Española SD, Grainger S, Pouget C, Traver D. PMID: 30208064; PMCID: PMC6135377.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun. 2018 04 03; 9(1):1310. Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana TM, Traver D, Miller YI. PMID: 29615667; PMCID: PMC5882990.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    11. WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development. Genes (Basel). 2018 Jan 29; 9(2). Richter J, Stanley EG, Ng ES, Elefanty AG, Traver D, Willert K. PMID: 29382179; PMCID: PMC5852562.
      View in: PubMed   Mentions: 10     Fields:    
    12. Wnt Signaling in Hematological Malignancies. Prog Mol Biol Transl Sci. 2018 01; 153:321-341. Grainger S, Traver D, Willert K. PMID: 29389522; PMCID: PMC5972548.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    13. Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. Dis Model Mech. 2017 12 19; 10(12):1439-1451. van der Vaart M, Svoboda O, Weijts BG, Espín-Palazón R, Sapp V, Pietri T, Bagnat M, Muotri AR, Traver D. PMID: 28993314; PMCID: PMC5769600.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    14. Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence. Trends Cell Biol. 2018 01; 28(1):58-66. Espin-Palazon R, Weijts B, Mulero V, Traver D. PMID: 28882414.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    15. The role of Wnt signaling in hematopoietic stem cell development. Crit Rev Biochem Mol Biol. 2017 08; 52(4):414-424. Richter J, Traver D, Willert K. PMID: 28508727; PMCID: PMC6104630.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    16. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464. Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çaglayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. PMID: 28092684; PMCID: PMC5325768.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    17. CRISPR Guide RNA Validation In Vitro. Zebrafish. 2017 Aug; 14(4):383-386. Grainger S, Lonquich B, Oon CH, Nguyen N, Willert K, Traver D. PMID: 27829120; PMCID: PMC5549792.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    18. Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Rep. 2016 11 01; 17(6):1595-1606. Grainger S, Richter J, Palazón RE, Pouget C, Lonquich B, Wirth S, Grassme KS, Herzog W, Swift MR, Weinstein BM, Traver D, Willert K. PMID: 27806298; PMCID: PMC6309681.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    19. The NF-κB family: Key players during embryonic development and HSC emergence. Exp Hematol. 2016 07; 44(7):519-27. Espín-Palazón R, Traver D. PMID: 27132652.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    20. Complex regulation of HSC emergence by the Notch signaling pathway. Dev Biol. 2016 Jan 01; 409(1):129-138. Butko E, Pouget C, Traver D. PMID: 26586199; PMCID: PMC4708088.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    21. Zebrafish embryonic stromal trunk (ZEST) cells support hematopoietic stem and progenitor cell (HSPC) proliferation, survival, and differentiation. Exp Hematol. 2015 Dec; 43(12):1047-61. Campbell C, Su T, Lau RP, Shah A, Laurie PC, Avalos B, Aggio J, Harris E, Traver D, Stachura DL. PMID: 26391449; PMCID: PMC4666736.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Going with the flow: how shear stress signals the emergence of adult hematopoiesis. J Exp Med. 2015 May 04; 212(5):600. Traver D. PMID: 25941320; PMCID: PMC4419338.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development. 2015 Mar 15; 142(6):1050-61. Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Espín-Palazón R, Lawson ND, Dorsky R, Clements WK, Traver D. PMID: 25758220; PMCID: PMC4360177.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    24. Intimacy of the niche: perivascular remodeling cuddles incoming HSCs. Cell Stem Cell. 2015 Feb 05; 16(2):109-10. Sahai-Hernandez P, Traver D. PMID: 25658365; PMCID: PMC5918686.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    25. FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun. 2014 Nov 27; 5:5583. Lee Y, Manegold JE, Kim AD, Pouget C, Stachura DL, Clements WK, Traver D. PMID: 25428693; PMCID: PMC4271318.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    26. FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway. Nat Commun. 2014 Nov 27; 5:5588. Pouget C, Peterkin T, Simões FC, Lee Y, Traver D, Patient R. PMID: 25429520; PMCID: PMC4374634.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    27. Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014 Nov 20; 159(5):1070-1085. Espín-Palazón R, Stachura DL, Campbell CA, García-Moreno D, Del Cid N, Kim AD, Candel S, Meseguer J, Mulero V, Traver D. PMID: 25416946; PMCID: PMC4243083.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    28. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Mork LA, Crump JG, Traver D. PMID: 25230933; PMCID: PMC4253525.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    29. Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12; 5:4814. Ouyang K, Leandro Gomez-Amaro R, Stachura DL, Tang H, Peng X, Fang X, Traver D, Evans SM, Chen J. PMID: 25215520; PMCID: PMC5537137.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    30. Hematopoietic ontogeny in the axolotl. Blood. 2014 Aug 21; 124(8):1204-6. Stachura DL, Traver D. PMID: 25147373; PMCID: PMC4141503.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 2014 Aug 21; 512(7514):319-23. Kobayashi I, Kobayashi-Sun J, Kim AD, Pouget C, Fujita N, Suda T, Traver D. PMID: 25119047; PMCID: PMC4237229.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    32. Perspectives on antigen presenting cells in zebrafish. Dev Comp Immunol. 2014 Sep; 46(1):63-73. Lewis KL, Del Cid N, Traver D. PMID: 24685511; PMCID: PMC4158852.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    33. The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013 Dec 05; 122(24):3918-28. Stachura DL, Svoboda O, Campbell CA, Espín-Palazón R, Lau RP, Zon LI, Bartunek P, Traver D. PMID: 24128862; PMCID: PMC3854111.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    34. Fish pharming: zebrafish antileukemia screening. Blood. 2012 Jun 14; 119(24):5614-5. Clements WK, Traver D. PMID: 22700692.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    35. A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 2011 Jun 08; 474(7350):220-4. Clements WK, Kim AD, Ong KG, Moore JC, Lawson ND, Traver D. PMID: 21654806; PMCID: PMC3304471.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    36. Clonal analysis of hematopoietic progenitor cells in the zebrafish. Blood. 2011 Aug 04; 118(5):1274-82. Stachura DL, Svoboda O, Lau RP, Balla KM, Zon LI, Bartunek P, Traver D. PMID: 21415264; PMCID: PMC3152495.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    37. Characterization of the mononuclear phagocyte system in zebrafish. Blood. 2011 Jun 30; 117(26):7126-35. Wittamer V, Bertrand JY, Gutschow PW, Traver D. PMID: 21406720.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    38. Cellular dissection of zebrafish hematopoiesis. Methods Cell Biol. 2011; 101:75-110. Stachura DL, Traver D. PMID: 21550440.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    39. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14; 8(12):e1000559. Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. PMID: 21179498; PMCID: PMC3001897.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    40. Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 2010 Nov 11; 116(19):3944-54. Balla KM, Lugo-Villarino G, Spitsbergen JM, Stachura DL, Hu Y, Bañuelos K, Romo-Fewell O, Aroian RV, Traver D. PMID: 20713961; PMCID: PMC2981543.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    41. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature. 2010 Mar 04; 464(7285):108-11. Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D. PMID: 20154733; PMCID: PMC2858358.
      View in: PubMed   Mentions: 534     Fields:    Translation:AnimalsCells
    42. Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo. Blood. 2010 Apr 08; 115(14):2777-83. Bertrand JY, Cisson JL, Stachura DL, Traver D. PMID: 20107232; PMCID: PMC2854425.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    43. Hematopoietic cell development in the zebrafish embryo. Curr Opin Hematol. 2009 Jul; 16(4):243-8. Bertrand JY, Traver D. PMID: 19491671.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    44. Zebrafish wnt3 is expressed in developing neural tissue. Dev Dyn. 2009 Jul; 238(7):1788-95. Clements WK, Ong KG, Traver D. PMID: 19452545; PMCID: PMC3086138.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    45. Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood. 2009 Jul 09; 114(2):279-89. Stachura DL, Reyes JR, Bartunek P, Paw BH, Zon LI, Traver D. PMID: 19433857; PMCID: PMC2714204.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    46. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet. 2008 Aug; 83(2):170-9. Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent S, Attié-Bitach T, Holden KR, Dobyns WB, Traver D, Al-Gazali L, Ali BR, Lindner TH, Caspary T, Otto EA, Hildebrandt F, Glass IA, Logan CV, Johnson CA, Bennett C, Brancati F, International Joubert Syndrome Related Disorders Study Group, Valente EM, Woods CG, Gleeson JG. PMID: 18674751; PMCID: PMC2495072.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansAnimalsCells
    47. CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development. 2008 May; 135(10):1853-62. Bertrand JY, Kim AD, Teng S, Traver D. PMID: 18417622; PMCID: PMC2762343.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    48. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development. 2007 Dec; 134(23):4147-56. Bertrand JY, Kim AD, Violette EP, Stachura DL, Cisson JL, Traver D. PMID: 17959717; PMCID: PMC2735398.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    49. The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn. 2007 Aug; 236(8):2268-76. Ablooglu AJ, Kang J, Handin RI, Traver D, Shattil SJ. PMID: 17626277.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    50. Cellular dissection of zebrafish hematopoiesis. Methods Cell Biol. 2004; 76:127-49. Traver D. PMID: 15602875.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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