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Nicholas Spitzer

Title(s)Professor, Neurobiology
SchoolAcademic Aff
Phone858-534-2456
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    Collapse Research 
    Collapse Research Activities and Funding
    Drugs of abuse drive transmitter switching that causes drug-induced behavior
    NIH/NIDA R21DA048633Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Running-induced Neurotransmitter Switching Enhances Acquisition of Motor Skills
    NIH/NINDS R56NS107549Apr 1, 2019 - Mar 31, 2020
    Role: Principal Investigator
    Neurotransmitter Switching and Its Function in Hippocampal Plasticity
    NIH/NIMH R21MH105706Sep 10, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Analysis of Activity Dependent Mechanisms of Neuronal Differentiation
    NIH/NINDS R01NS057690Dec 1, 2006 - Jan 31, 2019
    Role: Principal Investigator
    Mechanisms of Calcium Transients in Neuronal Development
    NIH/NIMH R01MH074702Jun 1, 2006 - Aug 31, 2011
    Role: Principal Investigator
    Mechanisms of Calcium Transients in Neuronal Development
    NIH/NIMH R56MH074702Sep 25, 2005 - May 31, 2006
    Role: Principal Investigator
    MECHANISMS OF GENERATION OF GROWTH CONE CALCIUM WAVES
    NIH/NINDS R01NS037002Sep 8, 1998 - Aug 31, 2002
    Role: Principal Investigator
    TARGET GENES OF TRANSCRIPTION FACTORS IN XENOPUS
    NIH/FIC F06TW001998Aug 17, 1994
    Role: Principal Investigator
    INDUCTION AND COMPENTENCE IN THE RETINA
    NIH/NEI R01EY010422Jul 1, 1994 - Jun 30, 1998
    Role: Principal Investigator
    FORMATION OF NEURAL PATHWAYS IN THE EMBRYO
    NIH/NEI R01EY010770Jul 1, 1994 - Jun 30, 1997
    Role: Principal Investigator
    MOLECULAR AND BIOPHYSICAL ASPECTS OF NEURONAL SIGNALING
    NIH/NINDS P01NS025916Mar 1, 1988 - Feb 28, 1997
    Role: Co-Investigator
    FORMATION OF NEURAL PATHWAYS IN THE AMPHIBIAN EMBRYO
    NIH/NICHD K04HD000528Jul 1, 1983 - Jun 30, 1988
    Role: Principal Investigator
    Neural Circuits Postdoctoral Training Program
    NIH/NINDS T32NS007220Jul 1, 1982 - Jun 30, 2024
    Role: Principal Investigator
    FORMATION OF NEURAL PATHWAYS IN THE EMBRYO
    NIH/NICHD R01HD014490Sep 30, 1980 - May 31, 1993
    Role: Principal Investigator
    Development of Neurons
    NIH/NINDS R01NS015918Jan 1, 1980 - Mar 31, 2018
    Role: Principal Investigator
    Development of Neurons
    NIH/NINDS R56NS015918Jan 1, 1980 - Jun 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pritchard R, Chen H, Romoli B, Spitzer NC, Dulcis D. Photoperiod-induced neurotransmitter plasticity declines with aging: An epigenetic regulation? J Comp Neurol. 2019 Jul 25. PMID: 31343079.
      View in: PubMed
    2. Meng D, Li HQ, Deisseroth K, Leutgeb S, Spitzer NC. Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. Proc Natl Acad Sci U S A. 2018 05 15; 115(20):5064-5071. PMID: 29686073.
      View in: PubMed
    3. Dulcis D, Lippi G, Stark CJ, Do LH, Berg DK, Spitzer NC. Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron. 2017 Sep 13; 95(6):1319-1333.e5. PMID: 28867550.
      View in: PubMed
    4. Spitzer NC. Neurotransmitter Switching in the Developing and Adult Brain. Annu Rev Neurosci. 2017 07 25; 40:1-19. PMID: 28301776.
      View in: PubMed
    5. Aumann TD, Raabus M, Tomas D, Prijanto A, Churilov L, Spitzer NC, Horne MK. Differences in Number of Midbrain Dopamine Neurons Associated with Summer and Winter Photoperiods in Humans. PLoS One. 2016; 11(7):e0158847. PMID: 27428306; PMCID: PMC4948786.
      View in: PubMed, PubMed Central
    6. Spitzer NC. DEVELOPMENTAL NEUROSCIENCE. Neurotransmitter-tailored dendritic trees. Science. 2015 Oct 30; 350(6260):510-1. PMID: 26516267.
      View in: PubMed
    7. Vincent P, Spitzer NC. Editorial: Dynamics of cyclic nucleotide signaling in neurons. Front Cell Neurosci. 2015; 9:296. PMID: 26283926; PMCID: PMC4522550.
      View in: PubMed, PubMed Central
    8. Spitzer NC. Neurotransmitter Switching? No Surprise. Neuron. 2015 Jun 03; 86(5):1131-44. PMID: 26050033; PMCID: PMC4458710.
      View in: PubMed, PubMed Central
    9. Griesi-Oliveira K, Acab A, Gupta AR, Sunaga DY, Chailangkarn T, Nicol X, Nunez Y, Walker MF, Murdoch JD, Sanders SJ, Fernandez TV, Ji W, Lifton RP, Vadasz E, Dietrich A, Pradhan D, Song H, Ming GL, Gu X, Haddad G, Marchetto MC, Spitzer N, Passos-Bueno MR, State MW, Muotri AR. Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Mol Psychiatry. 2015 Nov; 20(11):1350-65. PMID: 25385366; PMCID: PMC4427554.
      View in: PubMed, PubMed Central
    10. Guemez-Gamboa A, Xu L, Meng D, Spitzer NC. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching. Neuron. 2014 Jun 04; 82(5):1004-16. PMID: 24908484; PMCID: PMC4072120.
      View in: PubMed, PubMed Central
    11. Yang JM, Zhang J, Chen XJ, Geng HY, Ye M, Spitzer NC, Luo JH, Duan SM, Li XM. Development of GABA circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of erbb4-mutant mice. J Neurosci. 2013 Dec 11; 33(50):19724-33. PMID: 24336736.
      View in: PubMed
    12. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. PMID: 24139032.
      View in: PubMed
    13. Spitzer NC, Borodinsky LN, Root CM. Imaging and manipulating calcium transients in developing Xenopus spinal neurons. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):653-64. PMID: 23818661.
      View in: PubMed
    14. Dulcis D, Jamshidi P, Leutgeb S, Spitzer NC. Neurotransmitter switching in the adult brain regulates behavior. Science. 2013 Apr 26; 340(6131):449-53. PMID: 23620046.
      View in: PubMed
    15. Plazas PV, Nicol X, Spitzer NC. Activity-dependent competition regulates motor neuron axon pathfinding via PlexinA3. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1524-9. PMID: 23302694; PMCID: PMC3557035.
      View in: PubMed, PubMed Central
    16. Dulcis D, Spitzer NC. Reserve pool neuron transmitter respecification: Novel neuroplasticity. Dev Neurobiol. 2012 Apr; 72(4):465-74. PMID: 21595049; PMCID: PMC3192250.
      View in: PubMed, PubMed Central
    17. Spitzer NC. Activity-dependent neurotransmitter respecification. Nat Rev Neurosci. 2012 Jan 18; 13(2):94-106. PMID: 22251956; PMCID: PMC4352171.
      View in: PubMed, PubMed Central
    18. Demarque M, Spitzer NC. Neurotransmitter phenotype plasticity: an unexpected mechanism in the toolbox of network activity homeostasis. Dev Neurobiol. 2012 Jan; 72(1):22-32. PMID: 21557513; PMCID: PMC3209552.
      View in: PubMed, PubMed Central
    19. Rosenberg SS, Spitzer NC. Calcium signaling in neuronal development. Cold Spring Harb Perspect Biol. 2011 Oct 01; 3(10):a004259. PMID: 21730044; PMCID: PMC3179332.
      View in: PubMed, PubMed Central
    20. Nicol X, Hong KP, Spitzer NC. Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13776-81. PMID: 21795610; PMCID: PMC3158175.
      View in: PubMed, PubMed Central
    21. Hong KP, Spitzer NC, Nicol X. Improved molecular toolkit for cAMP studies in live cells. BMC Res Notes. 2011 Jul 20; 4:241. PMID: 21774821; PMCID: PMC3152522.
      View in: PubMed, PubMed Central
    22. Eyler LT, Prom-Wormley E, Fennema-Notestine C, Panizzon MS, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Stevens A, Pacheco J, Perry ME, Schmitt JE, Spitzer NC, Seidman LJ, Thermenos HW, Tsuang MT, Dale AM, Kremen WS. Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study. Hum Brain Mapp. 2011 Apr; 32(4):641-53. PMID: 20572207; PMCID: PMC3403693.
      View in: PubMed, PubMed Central
    23. Velázquez-Ulloa NA, Spitzer NC, Dulcis D. Contexts for dopamine specification by calcium spike activity in the CNS. J Neurosci. 2011 Jan 05; 31(1):78-88. PMID: 21209192; PMCID: PMC3080040.
      View in: PubMed, PubMed Central
    24. Ben-Ari Y, Spitzer NC. Phenotypic checkpoints regulate neuronal development. Trends Neurosci. 2010 Nov; 33(11):485-92. PMID: 20864191; PMCID: PMC2963711.
      View in: PubMed, PubMed Central
    25. Demarque M, Spitzer NC. Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron. 2010 Jul 29; 67(2):321-34. PMID: 20670838; PMCID: PMC2913149.
      View in: PubMed, PubMed Central
    26. Marek KW, Kurtz LM, Spitzer NC. cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification. Nat Neurosci. 2010 Aug; 13(8):944-50. PMID: 20581840; PMCID: PMC2910808.
      View in: PubMed, PubMed Central
    27. Xiao Q, Xu L, Spitzer NC. Target-dependent regulation of neurotransmitter specification and embryonic neuronal calcium spike activity. J Neurosci. 2010 Apr 21; 30(16):5792-801. PMID: 20410131; PMCID: PMC2871059.
      View in: PubMed, PubMed Central
    28. Spitzer NC. How GABA generates depolarization. J Physiol. 2010 Mar 01; 588(Pt 5):757-8. PMID: 20194137; PMCID: PMC2834934.
      View in: PubMed, PubMed Central
    29. McNerney CD, Chang EJ, Spitzer NC. Brain awareness week and beyond: encouraging the next generation. J Undergrad Neurosci Educ. 2009; 8(1):A61-5. PMID: 23493673; PMCID: PMC3592700.
      View in: PubMed, PubMed Central
    30. Chang LW, Spitzer NC. Spontaneous calcium spike activity in embryonic spinal neurons is regulated by developmental expression of the Na+, K+-ATPase beta3 subunit. J Neurosci. 2009 Jun 17; 29(24):7877-85. PMID: 19535599; PMCID: PMC3090545.
      View in: PubMed, PubMed Central
    31. Spitzer NC. Neuroscience: A bar code for differentiation. Nature. 2009 Apr 16; 458(7240):843-4. PMID: 19370023.
      View in: PubMed
    32. Frantz KJ, McNerney CD, Spitzer NC. We've got NERVE: a call to arms for neuroscience education. J Neurosci. 2009 Mar 18; 29(11):3337-9. PMID: 19295139.
      View in: PubMed
    33. Dulcis D, Spitzer NC. Illumination controls differentiation of dopamine neurons regulating behaviour. Nature. 2008 Nov 13; 456(7219):195-201. PMID: 19005547; PMCID: PMC2803045.
      View in: PubMed, PubMed Central
    34. Spitzer NC. A Rosetta stone for analysis of human membrane protein function. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10641-2. PMID: 18669649; PMCID: PMC2504841.
      View in: PubMed, PubMed Central
    35. Root CM, Velázquez-Ulloa NA, Monsalve GC, Minakova E, Spitzer NC. Embryonically expressed GABA and glutamate drive electrical activity regulating neurotransmitter specification. J Neurosci. 2008 Apr 30; 28(18):4777-84. PMID: 18448654; PMCID: PMC3318922.
      View in: PubMed, PubMed Central
    36. Spitzer NC, Borodinsky LN. Implications of activity-dependent neurotransmitter-receptor matching. Philos Trans R Soc Lond B Biol Sci. 2008 Apr 12; 363(1495):1393-9. PMID: 18198155; PMCID: PMC2610128.
      View in: PubMed, PubMed Central
    37. Sann SB, Xu L, Nishimune H, Sanes JR, Spitzer NC. Neurite outgrowth and in vivo sensory innervation mediated by a Ca(V)2.2-laminin beta 2 stop signal. J Neurosci. 2008 Mar 05; 28(10):2366-74. PMID: 18322083.
      View in: PubMed
    38. Spitzer NC. Calcium: first messenger. Nat Neurosci. 2008 Mar; 11(3):243-4. PMID: 18301428.
      View in: PubMed
    39. Borodinsky LN, Spitzer NC. Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):335-40. PMID: 17190810; PMCID: PMC1749326.
      View in: PubMed, PubMed Central
    40. Spitzer NC. Electrical activity in early neuronal development. Nature. 2006 Dec 07; 444(7120):707-12. PMID: 17151658.
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    41. Borodinsky LN, Spitzer NC. Second messenger pas de deux: the coordinated dance between calcium and cAMP. Sci STKE. 2006 May 23; 2006(336):pe22. PMID: 16720840.
      View in: PubMed
    42. Conklin MW, Lin MS, Spitzer NC. Local calcium transients contribute to disappearance of pFAK, focal complex removal and deadhesion of neuronal growth cones and fibroblasts. Dev Biol. 2005 Nov 01; 287(1):201-12. PMID: 16202989.
      View in: PubMed
    43. Bregestovski P, Spitzer N. Calcium in the function of the nervous system: new implications. Cell Calcium. 2005 May; 37(5):371-4. PMID: 15820383.
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    44. Spitzer NC, Borodinsky LN, Root CM. Homeostatic activity-dependent paradigm for neurotransmitter specification. Cell Calcium. 2005 May; 37(5):417-23. PMID: 15820389.
      View in: PubMed
    45. Ben-Ari Y, Spitzer NC. Nature and nurture in brain development. Trends Neurosci. 2004 Jul; 27(7):361. PMID: 15219731.
      View in: PubMed
    46. Spitzer NC, Root CM, Borodinsky LN. Orchestrating neuronal differentiation: patterns of Ca2+ spikes specify transmitter choice. Trends Neurosci. 2004 Jul; 27(7):415-21. PMID: 15219741.
      View in: PubMed
    47. Borodinsky LN, Root CM, Cronin JA, Sann SB, Gu X, Spitzer NC. Activity-dependent homeostatic specification of transmitter expression in embryonic neurons. Nature. 2004 Jun 03; 429(6991):523-30. PMID: 15175743.
      View in: PubMed
    48. Spitzer NC. Coincidence detection enhances appropriate wiring of the nervous system. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5311-2. PMID: 15067118; PMCID: PMC397370.
      View in: PubMed, PubMed Central
    49. Li H, Cook JD, Terry M, Spitzer NC, Ferrari MB. Calcium transients regulate patterned actin assembly during myofibrillogenesis. Dev Dyn. 2004 Feb; 229(2):231-42. PMID: 14745949.
      View in: PubMed
    50. Gorbunova YV, Spitzer NC. Dynamic interactions of cyclic AMP transients and spontaneous Ca(2+) spikes. Nature. 2002 Jul 04; 418(6893):93-6. PMID: 12097913.
      View in: PubMed
    51. Spitzer NC, Kingston PA, Manning TJ, Conklin MW. Outside and in: development of neuronal excitability. Curr Opin Neurobiol. 2002 Jun; 12(3):315-23. PMID: 12049939.
      View in: PubMed
    52. Ming GL, Wong ST, Henley J, Yuan XB, Song HJ, Spitzer NC, Poo MM. Adaptation in the chemotactic guidance of nerve growth cones. Nature. 2002 May 23; 417(6887):411-8. PMID: 11986620.
      View in: PubMed
    53. Spitzer NC. Activity-dependent neuronal differentiation prior to synapse formation: the functions of calcium transients. J Physiol Paris. 2002 Jan-Mar; 96(1-2):73-80. PMID: 11755785.
      View in: PubMed
    54. Fickbohm DJ, Lynn-Bullock CP, Spitzer N, Caldwell HK, Katz PS. Localization and quantification of 5-hydroxytryptophan and serotonin in the central nervous systems of Tritonia and Aplysia. J Comp Neurol. 2001 Aug 13; 437(1):91-105. PMID: 11477599.
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    55. Gomez TM, Robles E, Poo M, Spitzer NC. Filopodial calcium transients promote substrate-dependent growth cone turning. Science. 2001 Mar 09; 291(5510):1983-7. PMID: 11239161.
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    56. Spitzer NC, Vincent A, Lautermilch NJ. Differentiation of electrical excitability in motoneurons. Brain Res Bull. 2000 Nov 15; 53(5):547-52. PMID: 11165790.
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    57. Watt SD, Gu X, Smith RD, Spitzer NC. Specific frequencies of spontaneous Ca2+ transients upregulate GAD 67 transcripts in embryonic spinal neurons. Mol Cell Neurosci. 2000 Oct; 16(4):376-87. PMID: 11085875.
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    58. Spitzer NC, Lautermilch NJ, Smith RD, Gomez TM. Coding of neuronal differentiation by calcium transients. Bioessays. 2000 Sep; 22(9):811-7. PMID: 10944583.
      View in: PubMed
    59. Vincent A, Lautermilch NJ, Spitzer NC. Antisense suppression of potassium channel expression demonstrates its role in maturation of the action potential. J Neurosci. 2000 Aug 15; 20(16):6087-94. PMID: 10934258.
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    60. Gomez TM, Spitzer NC. Regulation of growth cone behavior by calcium: new dynamics to earlier perspectives. J Neurobiol. 2000 Aug; 44(2):174-83. PMID: 10934320.
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    61. Gurantz D, Lautermilch NJ, Watt SD, Spitzer NC. Sustained upregulation in embryonic spinal neurons of a Kv3.1 potassium channel gene encoding a delayed rectifier current. J Neurobiol. 2000 Feb 15; 42(3):347-56. PMID: 10645974.
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    62. Lautermilch NJ, Spitzer NC. Regulation of calcineurin by growth cone calcium waves controls neurite extension. J Neurosci. 2000 Jan 01; 20(1):315-25. PMID: 10627609.
      View in: PubMed
    63. Rohrbough J, Spitzer NC. Ca(2+)-permeable AMPA receptors and spontaneous presynaptic transmitter release at developing excitatory spinal synapses. J Neurosci. 1999 Oct 01; 19(19):8528-41. PMID: 10493753.
      View in: PubMed
    64. Ferrari MB, Spitzer NC. Calcium signaling in the developing Xenopus myotome. Dev Biol. 1999 Sep 15; 213(2):269-82. PMID: 10479447.
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    65. Spitzer NC. New dimensions of neuronal plasticity. Nat Neurosci. 1999 Jun; 2(6):489-91. PMID: 10448206.
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    66. Gomez TM, Spitzer NC. In vivo regulation of axon extension and pathfinding by growth-cone calcium transients. Nature. 1999 Jan 28; 397(6717):350-5. PMID: 9950427.
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    67. Olson EC, Schinder AF, Dantzker JL, Marcus EA, Spitzer NC, Harris WA. Properties of ectopic neurons induced by Xenopus neurogenin1 misexpression. Mol Cell Neurosci. 1998 Nov; 12(4-5):281-99. PMID: 9828092.
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    68. Spitzer NC, Ribera AB. Development of electrical excitability in embryonic neurons: mechanisms and roles. J Neurobiol. 1998 Oct; 37(1):190-7. PMID: 9777741.
      View in: PubMed
    69. Jessen-Eller K, Steele M, Reinisch C, Spitzer N. Blockade of ryanodine receptors stimulates neurite outgrowth in embryos of Spisula solidissima. Biol Bull. 1998 Oct; 195(2):206-7. PMID: 9818372.
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    70. Ribera AB, Spitzer NC. Development of electrical excitability: mechanisms and roles. J Neurobiol. 1998 Oct; 37(1):1-2. PMID: 9777728.
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    71. Ferrari MB, Ribbeck K, Hagler DJ, Spitzer NC. A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes. J Cell Biol. 1998 Jun 15; 141(6):1349-56. PMID: 9628891.
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    72. Gleason EL, Spitzer NC. AMPA and NMDA receptors expressed by differentiating Xenopus spinal neurons. J Neurophysiol. 1998 Jun; 79(6):2986-98. PMID: 9636102.
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    73. Spitzer NC, Sejnowski TJ. Biological information processing: bits of progress. Science. 1997 Aug 22; 277(5329):1060-1. PMID: 9289851.
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    74. Spitzer NC, Gu X. Purposeful patterns of spontaneous calcium transients in embryonic spinal neurons. Semin Cell Dev Biol. 1997 Feb; 8(1):13-9. PMID: 15001100.
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    75. Gu X, Spitzer NC. Breaking the code: regulation of neuronal differentiation by spontaneous calcium transients. Dev Neurosci. 1997; 19(1):33-41. PMID: 9078431.
      View in: PubMed
    76. Schinder AF, Olson EC, Spitzer NC, Montal M. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci. 1996 Oct 01; 16(19):6125-33. PMID: 8815895.
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    77. Ferrari MB, Rohrbough J, Spitzer NC. Spontaneous calcium transients regulate myofibrillogenesis in embryonic Xenopus myocytes. Dev Biol. 1996 Sep 15; 178(2):484-97. PMID: 8812144.
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    78. Gurantz D, Ribera AB, Spitzer NC. Temporal regulation of Shaker- and Shab-like potassium channel gene expression in single embryonic spinal neurons during K+ current development. J Neurosci. 1996 May 15; 16(10):3287-95. PMID: 8627366.
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    79. Rohrbough J, Spitzer NC. Regulation of intracellular Cl- levels by Na(+)-dependent Cl- cotransport distinguishes depolarizing from hyperpolarizing GABAA receptor-mediated responses in spinal neurons. J Neurosci. 1996 Jan; 16(1):82-91. PMID: 8613812.
      View in: PubMed
    80. Gu X, Spitzer NC. Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients. Nature. 1995 Jun 29; 375(6534):784-7. PMID: 7596410.
      View in: PubMed
    81. Ernsberger U, Spitzer NC. Convertible modes of inactivation of potassium channels in Xenopus myocytes differentiating in vitro. J Physiol. 1995 Apr 15; 484 ( Pt 2):313-29. PMID: 7602528.
      View in: PubMed
    82. Spitzer NC, Olson E, Gu X. Spontaneous calcium transients regulate neuronal plasticity in developing neurons. J Neurobiol. 1995 Mar; 26(3):316-24. PMID: 7775965.
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    83. Spitzer NC. Spontaneous activity: functions of calcium transients in neuronal differentiation. Perspect Dev Neurobiol. 1995; 2(4):379-86. PMID: 7757407.
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    84. Gu X, Olson EC, Spitzer NC. Spontaneous neuronal calcium spikes and waves during early differentiation. J Neurosci. 1994 Nov; 14(11 Pt 1):6325-35. PMID: 7965039.
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    85. Spitzer NC. Spontaneous Ca2+ spikes and waves in embryonic neurons: signaling systems for differentiation. Trends Neurosci. 1994 Mar; 17(3):115-8. PMID: 7515527.
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    86. Spitzer NC, Gu X, Olson E. Action potentials, calcium transients and the control of differentiation of excitable cells. Curr Opin Neurobiol. 1994 Feb; 4(1):70-7. PMID: 7513567.
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    87. Spitzer NC. Development of voltage-dependent and ligand-gated channels in excitable membranes. Prog Brain Res. 1994; 102:169-79. PMID: 7528434.
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    88. Spitzer NC. Calcium and gene expression. Prog Brain Res. 1994; 103:123-6. PMID: 7886200.
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    89. Gu X, Spitzer NC. Low-threshold Ca2+ current and its role in spontaneous elevations of intracellular Ca2+ in developing Xenopus neurons. J Neurosci. 1993 Nov; 13(11):4936-48. PMID: 8229206.
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    90. Spitzer NC, Debaca RC, Allen KA, Holliday J. Calcium dependence of differentiation of GABA immunoreactivity in spinal neurons. J Comp Neurol. 1993 Nov 01; 337(1):168-75. PMID: 7506271.
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    91. Desarmenien MG, Clendening B, Spitzer NC. In vivo development of voltage-dependent ionic currents in embryonic Xenopus spinal neurons. J Neurosci. 1993 Jun; 13(6):2575-81. PMID: 8501523.
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    92. Holliday J, Spitzer NC. Calcium regulates neuronal differentiation both directly and via co-cultured myocytes. J Neurobiol. 1993 Apr; 24(4):506-14. PMID: 8515253.
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    93. Lockery SR, Spitzer NC. Reconstruction of action potential development from whole-cell currents of differentiating spinal neurons. J Neurosci. 1992 Jun; 12(6):2268-87. PMID: 1607940.
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    94. Ribera AB, Spitzer NC. Developmental regulation of potassium channels and the impact on neuronal differentiation. Ion Channels. 1992; 3:1-38. PMID: 1421060.
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    95. Holliday J, Adams RJ, Sejnowski TJ, Spitzer NC. Calcium-induced release of calcium regulates differentiation of cultured spinal neurons. Neuron. 1991 Nov; 7(5):787-96. PMID: 1742025.
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    96. Desarmenien MG, Spitzer NC. Role of calcium and protein kinase C in development of the delayed rectifier potassium current in Xenopus spinal neurons. Neuron. 1991 Nov; 7(5):797-805. PMID: 1742026.
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    97. Spitzer NC. A developmental handshake: neuronal control of ionic currents and their control of neuronal differentiation. J Neurobiol. 1991 Oct; 22(7):659-73. PMID: 1722506.
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    98. Ribera AB, Spitzer NC. Differentiation of delayed rectifier potassium current in embryonic amphibian myocytes. Dev Biol. 1991 Mar; 144(1):119-28. PMID: 1995391.
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    99. Holliday J, Spitzer NC. Spontaneous calcium influx and its roles in differentiation of spinal neurons in culture. Dev Biol. 1990 Sep; 141(1):13-23. PMID: 2167857.
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    100. Ribera AB, Spitzer NC. Differentiation of IKA in amphibian spinal neurons. J Neurosci. 1990 Jun; 10(6):1886-91. PMID: 2355255.
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    101. Ribera AB, Spitzer NC. A critical period of transcription required for differentiation of the action potential of spinal neurons. Neuron. 1989 Jan; 2(1):1055-62. PMID: 2483107.
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    102. Harris GL, Henderson LP, Spitzer NC. Changes in densities and kinetics of delayed rectifier potassium channels during neuronal differentiation. Neuron. 1988 Oct; 1(8):739-50. PMID: 3272186.
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    103. O'Dowd DK, Ribera AB, Spitzer NC. Development of voltage-dependent calcium, sodium, and potassium currents in Xenopus spinal neurons. J Neurosci. 1988 Mar; 8(3):792-805. PMID: 3346722.
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    104. Ribera AB, Spitzer NC. Both barium and calcium activate neuronal potassium currents. Proc Natl Acad Sci U S A. 1987 Sep; 84(18):6577-81. PMID: 2442762.
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    105. Henderson LP, Spitzer NC. Autonomous early differentiation of neurons and muscle cells in single cell cultures. Dev Biol. 1986 Feb; 113(2):381-7. PMID: 2868950.
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    106. Easter SS, Purves D, Rakic P, Spitzer NC. The changing view of neural specificity. Science. 1985 Nov 01; 230(4725):507-11. PMID: 4048944.
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    107. Spitzer NC. On the basis of delayed depolarization and its role in repetitive firing of Rohon-Beard neurones in Xenopus tadpoles. J Physiol. 1984 Dec; 357:51-65. PMID: 6512703.
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    108. Henderson LP, Smith MA, Spitzer NC. The absence of calcium blocks impulse-evoked release of acetylcholine but not de novo formation of functional neuromuscular synaptic contacts in culture. J Neurosci. 1984 Dec; 4(12):3140-50. PMID: 6094749.
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    109. Bixby JL, Spitzer NC. Early differentiation of vertebrate spinal neurons in the absence of voltage-dependent Ca2+ and Na+ influx. Dev Biol. 1984 Nov; 106(1):89-96. PMID: 6092180.
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    110. Bixby JL, Spitzer NC. The appearance and development of neurotransmitter sensitivity in Xenopus embryonic spinal neurones in vitro. J Physiol. 1984 Aug; 353:143-55. PMID: 6148408.
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    111. Bixby JL, Spitzer NC. Enkephalin reduces calcium action potentials in Rohon-Beard neurons in vivo. J Neurosci. 1983 May; 3(5):1014-8. PMID: 6842279.
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    112. Bixby JL, Spitzer NC. Enkephalin reduces quantal content at the frog neuromuscular junction. Nature. 1983 Feb 03; 301(5899):431-2. PMID: 6823319.
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    113. Bixby JL, Spitzer NC. The appearance and development of chemosensitivity in Rohon-Beard neurones of the Xenopus spinal cord. J Physiol. 1982 Sep; 330:513-36. PMID: 6294289.
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    114. Spitzer NC. Voltage- and stage-dependent uncoupling of Rohon-Beard neurones during embryonic development of Xenopus tadpoles. J Physiol. 1982 Sep; 330:145-62. PMID: 7175739.
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    115. Goodman CS, Spitzer NC. The mature electrical properties of identified neurones in grasshopper embryos. J Physiol. 1981; 313:369-84. PMID: 7277226.
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    116. Bate M, Goodman CS, Spitzer NC. Embryonic development of identified neurons: segment-specific differences in the H cell homologues. J Neurosci. 1981 Jan; 1(1):103-6. PMID: 7346554.
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    117. Goodman CS, Bate M, Spitzer NC. Embryonic development of identified neurons: origin and transformation of the H cell. J Neurosci. 1981 Jan; 1(1):94-102. PMID: 7346562.
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    118. Goodman CS, Spitzer NC. The development of electrical properties of identified neurones in grasshopper embryos. J Physiol. 1981; 313:385-403. PMID: 7277228.
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    119. Goodman CS, Pearson KG, Spitzer NC. Electrical excitability: a spectrum of properties in the progeny of a single embryonic neuroblast. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1676-80. PMID: 6246499.
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    120. Darszon A, Vandenberg CA, Schönfeld M, Ellisman MH, Spitzer NC, Montal M. Reassembly of protein-lipid complexes into large bilayer vesicles: perspectives for membrane reconstitution. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):239-43. PMID: 6244547.
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    121. Goodman CS, Spitzer NC. Embryonic development of identified neurones: differentiation from neuroblast to neurone. Nature. 1979 Jul 19; 280(5719):208-14. PMID: 450137.
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    122. Goodman CS, O'Shea M, McCaman R, Spitzer NC. Embryonic development of identified neurons: temporal pattern of morphological and biochemical differentiation. Science. 1979 Jun 15; 204(4398):1219-22. PMID: 36661.
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    123. Lamborghini JE, Revenaugh M, Spitzer NC. Ultrastructural development of Rohon-Beard neurons: loss of intramitochondrial granules parallels loss of calcium action potentials. J Comp Neurol. 1979 Feb 15; 183(4):741-52. PMID: 762270.
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    124. Spitzer NC. Low pH selectively blocks calcium action potentials in amphibian neurons developing in culture. Brain Res. 1979 Feb 09; 161(3):555-9. PMID: 33747.
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    125. Spitzer NC. Ion channels in development. Annu Rev Neurosci. 1979; 2:363-97. PMID: 395884.
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    126. Baccaglini PI, Spitzer NC. Developmental changes in the inward current of the action potential of Rohon-Beard neurones. J Physiol. 1977 Sep; 271(1):93-117. PMID: 915836.
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    127. Spitzer NC, Baccaglini PI. Development of the action potential in embryo amphibian neurons in vivo. Brain Res. 1976 May 14; 107(3):610-6. PMID: 1268744.
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    128. Spitzer NC, Lamborghini JE. The development of the action potential mechanism of amphibian neurons isolated in culture. Proc Natl Acad Sci U S A. 1976 May; 73(5):1641-5. PMID: 1064036.
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    129. Spitzer NC. The ionic basis of the resting potential and a slow depolarizing response in Rohon-Beard neurones of Xenopus tadpoles. J Physiol. 1976 Feb; 255(1):105-35. PMID: 1255512.
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    130. Doore BJ, Bashor MM, Spitzer N, Mawe RC, Saier MH. Regulation of adenosine 3' :5'-monophosphate efflux from rat glioma cells in culture*. J Biol Chem. 1975 Jun 10; 250(11):4371-2. PMID: 165200.
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    131. Miledi R, Spitzer NC. Absence of action potentials in frog slow muscle fibres paralysed by botulinum toxin. J Physiol. 1974 Aug; 241(1):183-99. PMID: 4371279.
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    132. Holman ME, Spitzer NC. Action of botulinum toxin on transmission from sympathetic nerves to the vas deferens. Br J Pharmacol. 1973 Feb; 47(2):431-3. PMID: 4352870.
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    133. McMahan UJ, Spitzer NC. Viewing neuromuscular junctions in live, unstained skeletal muscle. J Physiol. 1971 Jul; 216(1):35P-37P. PMID: 5558366.
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    134. Spitzer NC. Low resistance connections between cells in the developing anther of the lily. J Cell Biol. 1970 Jun; 45(3):565-75. PMID: 4918215.
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