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Robert Hevner

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-246-3229
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    Collapse Research 
    Collapse Research Activities and Funding
    Development and Malformations of the Dentate Gyrus
    NIH/NINDS R01NS092339Mar 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    Intermediate neuronal progenitors in neocortical development
    NIH/NINDS R01NS085081Sep 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Mosaic Xlr3 Gene Expression in the Female Embryonic Mouse Brain
    NIH/NIMH R21MH099628Jan 1, 2013 - Dec 31, 2014
    Role: Principal Investigator
    Delta-Notch Signaling by Intermediate Neuronal Progenitors: Live Imaging
    NIH/NIMH R21MH087070Aug 1, 2009 - Nov 30, 2011
    Role: Principal Investigator
    Intermediate Progenitor Cells in Adult Hippocampal Neurogenesis
    NIH/NIMH R01MH080766Apr 1, 2007 - Mar 31, 2013
    Role: Principal Investigator
    Mechanisms of Neocortical Development Regulated by Tbr1
    NIH/NINDS R01NS050248Jul 1, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Regulation of Laminar Fate in Cerebral Cortex
    NIH/NINDS K02NS045018Sep 1, 2003 - Aug 31, 2007
    Role: Principal Investigator
    HOMEOBOX GENES AND FOREBRAIN DEVELOPMENT
    NIH/NINDS K08NS001973Sep 30, 1996 - Aug 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mihalas AB, Hevner RF. Clonal analysis reveals laminar fate multipotency and daughter cell apoptosis of mouse cortical intermediate progenitors. Development. 2018 Sep 14; 145(17). PMID: 30217810.
      View in: PubMed
    2. Dohare P, Kidwai A, Kaur J, Singla P, Krishna S, Klebe D, Zhang X, Hevner R, Ballabh P. GSK3ß Inhibition Restores Impaired Neurogenesis in Preterm Neonates With Intraventricular Hemorrhage. Cereb Cortex. 2018 Sep 06. PMID: 30192926.
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    3. Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF. The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6? Tbr2? Tbr1. Front Neurosci. 2018; 12:571. PMID: 30186101.
      View in: PubMed
    4. Adams Waldorf KM, Nelson BR, Stencel-Baerenwald JE, Studholme C, Kapur RP, Armistead B, Walker CL, Merillat S, Vornhagen J, Tisoncik-Go J, Baldessari A, Coleman M, Dighe MK, Shaw DWW, Roby JA, Santana-Ufret V, Boldenow E, Li J, Gao X, Davis MA, Swanstrom JA, Jensen K, Widman DG, Baric RS, Medwid JT, Hanley KA, Ogle J, Gough GM, Lee W, English C, Durning WM, Thiel J, Gatenby C, Dewey EC, Fairgrieve MR, Hodge RD, Grant RF, Kuller L, Dobyns WB, Hevner RF, Gale M, Rajagopal L. Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. Nat Med. 2018 Mar; 24(3):368-374. PMID: 29400709.
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    5. Alcantara D, Timms AE, Gripp K, Baker L, Park K, Collins S, Cheng C, Stewart F, Mehta SG, Saggar A, Sztriha L, Zombor M, Caluseriu O, Mesterman R, Van Allen MI, Jacquinet A, Ygberg S, Bernstein JA, Wenger AM, Guturu H, Bejerano G, Gomez-Ospina N, Lehman A, Alfei E, Pantaleoni C, Conti V, Guerrini R, Moog U, Graham JM, Hevner R, Dobyns WB, O'Driscoll M, Mirzaa GM. Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly. Brain. 2017 Oct 01; 140(10):2610-2622. PMID: 28969385.
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    6. Kaplan ES, Ramos-Laguna KA, Mihalas AB, Daza RAM, Hevner RF. Neocortical Sox9+ radial glia generate glutamatergic neurons for all layers, but lack discernible evidence of early laminar fate restriction. Neural Dev. 2017 Aug 16; 12(1):14. PMID: 28814327.
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    7. Probst S, Daza RA, Bader N, Hummel JF, Weiß M, Tanriver Y, Hevner RF, Arnold SJ. A dual-fluorescence reporter in the Eomes locus for live imaging and medium-term lineage tracing. Genesis. 2017 08; 55(8). PMID: 28646547.
      View in: PubMed
    8. Ha S, Tripathi PP, Mihalas AB, Hevner RF, Beier DR. C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus. J Neurosci. 2017 Jan 25; 37(4):960-971. PMID: 28123028.
      View in: PubMed
    9. Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RP, Studholme C, Boldenow E, Vornhagen J, Baldessari A, Dighe MK, Thiel J, Merillat S, Armistead B, Tisoncik-Go J, Green RR, Davis MA, Dewey EC, Fairgrieve MR, Gatenby JC, Richards T, Garden GA, Diamond MS, Juul SE, Grant RF, Kuller L, Shaw DW, Ogle J, Gough GM, Lee W, English C, Hevner RF, Dobyns WB, Gale M, Rajagopal L. Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat Med. 2016 11; 22(11):1256-1259. PMID: 27618651.
      View in: PubMed
    10. Mihalas AB, Hevner RF. Control of Neuronal Development by T-Box Genes in the Brain. Curr Top Dev Biol. 2017; 122:279-312. PMID: 28057268.
      View in: PubMed
    11. Bakken TE, Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Dalley RA, Royall JJ, Lemon T, Shapouri S, Aiona K, Arnold J, Bennett JL, Bertagnolli D, Bickley K, Boe A, Brouner K, Butler S, Byrnes E, Caldejon S, Carey A, Cate S, Chapin M, Chen J, Dee N, Desta T, Dolbeare TA, Dotson N, Ebbert A, Fulfs E, Gee G, Gilbert TL, Goldy J, Gourley L, Gregor B, Gu G, Hall J, Haradon Z, Haynor DR, Hejazinia N, Hoerder-Suabedissen A, Howard R, Jochim J, Kinnunen M, Kriedberg A, Kuan CL, Lau C, Lee CK, Lee F, Luong L, Mastan N, May R, Melchor J, Mosqueda N, Mott E, Ngo K, Nyhus J, Oldre A, Olson E, Parente J, Parker PD, Parry S, Pendergraft J, Potekhina L, Reding M, Riley ZL, Roberts T, Rogers B, Roll K, Rosen D, Sandman D, Sarreal M, Shapovalova N, Shi S, Sjoquist N, Sodt AJ, Townsend R, Velasquez L, Wagley U, Wakeman WB, White C, Bennett C, Wu J, Young R, Youngstrom BL, Wohnoutka P, Gibbs RA, Rogers J, Hohmann JG, Hawrylycz MJ, Hevner RF, Molnár Z, Phillips JW, Dang C, Jones AR, Amaral DG, Bernard A, Lein ES. A comprehensive transcriptional map of primate brain development. Nature. 2016 07 21; 535(7612):367-75. PMID: 27409810.
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    12. Mirzaa GM, Campbell CD, Solovieff N, Goold C, Jansen LA, Menon S, Timms AE, Conti V, Biag JD, Adams C, Boyle EA, Collins S, Ishak G, Poliachik S, Girisha KM, Yeung KS, Chung BHY, Rahikkala E, Gunter SA, McDaniel SS, Macmurdo CF, Bernstein JA, Martin B, Leary R, Mahan S, Liu S, Weaver M, Doerschner M, Jhangiani S, Muzny DM, Boerwinkle E, Gibbs RA, Lupski JR, Shendure J, Saneto RP, Novotny EJ, Wilson CJ, Sellers WR, Morrissey M, Hevner RF, Ojemann JG, Guerrini R, Murphy LO, Winckler W, Dobyns WB. Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism. JAMA Neurol. 2016 Jul 01; 73(7):836-845. PMID: 27159400; PMCID: PMC4979321.
    13. Mihalas AB, Elsen GE, Bedogni F, Daza RAM, Ramos-Laguna KA, Arnold SJ, Hevner RF. Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity. Cell Rep. 2016 06 28; 16(1):92-105. PMID: 27320921; PMCID: PMC4927342.
    14. Tronnes AA, Koschnitzky J, Daza R, Hitti J, Ramirez JM, Hevner R. Effects of Lipopolysaccharide and Progesterone Exposures on Embryonic Cerebral Cortex Development in Mice. Reprod Sci. 2016 06; 23(6):771-8. PMID: 26621965.
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    15. Easton CR, Dickey CW, Moen SP, Neuzil KE, Barger Z, Anderson TM, Moody WJ, Hevner RF. Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Dev Neurobiol. 2016 07; 76(7):705-20. PMID: 26473411.
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    16. Hevner RF. Evolution of the mammalian dentate gyrus. J Comp Neurol. 2016 Feb 15; 524(3):578-94. PMID: 26179319; PMCID: PMC4706817 [Available on 02/15/17].
    17. Jansen LA, Mirzaa GM, Ishak GE, O'Roak BJ, Hiatt JB, Roden WH, Gunter SA, Christian SL, Collins S, Adams C, Rivière JB, St-Onge J, Ojemann JG, Shendure J, Hevner RF, Dobyns WB. PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia. Brain. 2015 Jun; 138(Pt 6):1613-28. PMID: 25722288; PMCID: PMC4614119.
    18. Alfano C, Magrinelli E, Harb K, Hevner RF, Studer M. Postmitotic control of sensory area specification during neocortical development. Nat Commun. 2014 Dec 05; 5:5632. PMID: 25476200.
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    19. Hevner RF. Brain overgrowth in disorders of RTK-PI3K-AKT signaling: a mosaic of malformations. Semin Perinatol. 2015 Feb; 39(1):36-43. PMID: 25432429; PMCID: PMC4268391.
    20. Joseph JT, Innes AM, Smith AC, Vanstone MR, Schwartzentruber JA, Bulman DE, Majewski J, Daza RA, Hevner RF, Michaud J, Boycott KM. Neuropathologic features of pontocerebellar hypoplasia type 6. J Neuropathol Exp Neurol. 2014 Nov; 73(11):1009-25. PMID: 25289895.
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    21. Smith MJ, Wallace AJ, Bennett C, Hasselblatt M, Elert-Dobkowska E, Evans LT, Hickey WF, van Hoff J, Bauer D, Lee A, Hevner RF, Beetz C, du Plessis D, Kilday JP, Newman WG, Evans DG. Germline SMARCE1 mutations predispose to both spinal and cranial clear cell meningiomas. J Pathol. 2014 Dec; 234(4):436-40. PMID: 25143307.
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    22. Molnár Z, Kaas JH, de Carlos JA, Hevner RF, Lein E, Nemec P. Evolution and development of the mammalian cerebral cortex. Brain Behav Evol. 2014; 83(2):126-39. PMID: 24776993; PMCID: PMC4440552.
    23. Vose LR, Vinukonda G, Diamond D, Korumilli R, Hu F, Zia MT, Hevner R, Ballabh P. Prenatal betamethasone does not affect glutamatergic or GABAergic neurogenesis in preterm newborns. Neuroscience. 2014 Jun 13; 270:148-57. PMID: 24735821; PMCID: PMC4044920.
    24. Mirzaa G, Parry DA, Fry AE, Giamanco KA, Schwartzentruber J, Vanstone M, Logan CV, Roberts N, Johnson CA, Singh S, Kholmanskikh SS, Adams C, Hodge RD, Hevner RF, Bonthron DT, Braun KPJ, Faivre L, Rivière JB, St-Onge J, Gripp KW, Mancini GM, Pang K, Sweeney E, van Esch H, Verbeek N, Wieczorek D, Steinraths M, Majewski J, Boycot KM, Pilz DT, Ross ME, Dobyns WB, Sheridan EG. De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. Nat Genet. 2014 May; 46(5):510-515. PMID: 24705253; PMCID: PMC4004933.
    25. Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Ebbert A, Riley ZL, Royall JJ, Aiona K, Arnold JM, Bennet C, Bertagnolli D, Brouner K, Butler S, Caldejon S, Carey A, Cuhaciyan C, Dalley RA, Dee N, Dolbeare TA, Facer BA, Feng D, Fliss TP, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Howard RE, Jochim JM, Kuan CL, Lau C, Lee CK, Lee F, Lemon TA, Lesnar P, McMurray B, Mastan N, Mosqueda N, Naluai-Cecchini T, Ngo NK, Nyhus J, Oldre A, Olson E, Parente J, Parker PD, Parry SE, Stevens A, Pletikos M, Reding M, Roll K, Sandman D, Sarreal M, Shapouri S, Shapovalova NV, Shen EH, Sjoquist N, Slaughterbeck CR, Smith M, Sodt AJ, Williams D, Zöllei L, Fischl B, Gerstein MB, Geschwind DH, Glass IA, Hawrylycz MJ, Hevner RF, Huang H, Jones AR, Knowles JA, Levitt P, Phillips JW, Sestan N, Wohnoutka P, Dang C, Bernard A, Hohmann JG, Lein ES. Transcriptional landscape of the prenatal human brain. Nature. 2014 Apr 10; 508(7495):199-206. PMID: 24695229; PMCID: PMC4105188.
    26. Sun T, Hevner RF. Growth and folding of the mammalian cerebral cortex: from molecules to malformations. Nat Rev Neurosci. 2014 Apr; 15(4):217-32. PMID: 24646670; PMCID: PMC4107216.
    27. Easton CR, Weir K, Scott A, Moen SP, Barger Z, Folch A, Hevner RF, Moody WJ. Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex. J Neurosci. 2014 Mar 12; 34(11):3854-63. PMID: 24623764; PMCID: PMC3951690.
    28. Jansen LA, Hevner RF, Roden WH, Hahn SH, Jung S, Gospe SM. Glial localization of antiquitin: implications for pyridoxine-dependent epilepsy. Ann Neurol. 2014 Jan; 75(1):22-32. PMID: 24122892; PMCID: PMC3945410.
    29. Kahoud RJ, Elsen GE, Hevner RF, Hodge RD. Conditional ablation of Tbr2 results in abnormal development of the olfactory bulbs and subventricular zone-rostral migratory stream. Dev Dyn. 2014 Mar; 243(3):440-50. PMID: 24550175; PMCID: PMC3992892.
    30. Birlea M, Nagel MA, Khmeleva N, Choe A, Kleinschmidt-Demasters B, Hevner R, Boyer P, Lear-Kaul KC, Bos N, Wellish M, Cohrs RJ, Gilden D. Varicella-zoster virus trigeminal ganglioneuritis without rash. Neurology. 2014 Jan 07; 82(1):90-2. PMID: 24285619; PMCID: PMC3873618.
    31. Tornero D, Wattananit S, Grønning Madsen M, Koch P, Wood J, Tatarishvili J, Mine Y, Ge R, Monni E, Devaraju K, Hevner RF, Brüstle O, Lindvall O, Kokaia Z. Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery. Brain. 2013 Dec; 136(Pt 12):3561-77. PMID: 24148272.
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    32. Pimeisl IM, Tanriver Y, Daza RA, Vauti F, Hevner RF, Arnold HH, Arnold SJ. Generation and characterization of a tamoxifen-inducible Eomes(CreER) mouse line. Genesis. 2013 Oct; 51(10):725-33. PMID: 23897762; PMCID: PMC4112203.
    33. Shiba N, Daza RA, Shaffer LG, Barkovich AJ, Dobyns WB, Hevner RF. Neuropathology of brain and spinal malformations in a case of monosomy 1p36. Acta Neuropathol Commun. 2013 Aug 02; 1:45. PMID: 24252393; PMCID: PMC3893467.
    34. Nelson BR, Hodge RD, Bedogni F, Hevner RF. Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling. J Neurosci. 2013 May 22; 33(21):9122-39. PMID: 23699523; PMCID: PMC3716275.
    35. Hodge RD, Garcia AJ, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013 Feb 27; 33(9):4165-80. PMID: 23447624; PMCID: PMC3623668.
    36. Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJ, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci. 2013 Feb 20; 33(8):3633-45. PMID: 23426690; PMCID: PMC3652398.
    37. Elsen GE, Hodge RD, Bedogni F, Daza RA, Nelson BR, Shiba N, Reiner SL, Hevner RF. The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4081-6. PMID: 23431145; PMCID: PMC3593833.
    38. Malik S, Vinukonda G, Vose LR, Diamond D, Bhimavarapu BB, Hu F, Zia MT, Hevner R, Zecevic N, Ballabh P. Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth. J Neurosci. 2013 Jan 09; 33(2):411-23. PMID: 23303921; PMCID: PMC3711635.
    39. Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner RF, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S. Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nat Neurosci. 2013 Feb; 16(2):157-65. PMID: 23292680.
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    40. Myshrall TD, Moore SA, Ostendorf AP, Satz JS, Kowalczyk T, Nguyen H, Daza RA, Lau C, Campbell KP, Hevner RF. Dystroglycan on radial glia end feet is required for pial basement membrane integrity and columnar organization of the developing cerebral cortex. J Neuropathol Exp Neurol. 2012 Dec; 71(12):1047-63. PMID: 23147502; PMCID: PMC3512206.
    41. Kovach C, Dixit R, Li S, Mattar P, Wilkinson G, Elsen GE, Kurrasch DM, Hevner RF, Schuurmans C. Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex. Cereb Cortex. 2013 Aug; 23(8):1884-900. PMID: 22735158.
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    42. Hodge RD, Nelson BR, Kahoud RJ, Yang R, Mussar KE, Reiner SL, Hevner RF. Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons. J Neurosci. 2012 May 02; 32(18):6275-87. PMID: 22553033; PMCID: PMC3366485.
    43. Juric-Sekhar G, Adkins J, Doherty D, Hevner RF. Joubert syndrome: brain and spinal cord malformations in genotyped cases and implications for neurodevelopmental functions of primary cilia. Acta Neuropathol. 2012 May; 123(5):695-709. PMID: 22331178.
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    44. Hodge RD, Kahoud RJ, Hevner RF. Transcriptional control of glutamatergic differentiation during adult neurogenesis. Cell Mol Life Sci. 2012 Jul; 69(13):2125-34. PMID: 22249196; PMCID: PMC3360923.
    45. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24. PMID: 22458515; PMCID: PMC3439975.
    46. Hevner RF, Haydar TF. The (not necessarily) convoluted role of basal radial glia in cortical neurogenesis. Cereb Cortex. 2012 Feb; 22(2):465-8. PMID: 22116731; PMCID: PMC3256413.
    47. Hodge RD, Hevner RF. Expression and actions of transcription factors in adult hippocampal neurogenesis. Dev Neurobiol. 2011 Aug; 71(8):680-9. PMID: 21412988; PMCID: PMC3134120.
    48. Boyle MP, Bernard A, Thompson CL, Ng L, Boe A, Mortrud M, Hawrylycz MJ, Jones AR, Hevner RF, Lein ES. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 01; 519(11):2061-89. PMID: 21491433.
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    49. Hamilton SM, Spencer CM, Harrison WR, Yuva-Paylor LA, Graham DF, Daza RA, Hevner RF, Overbeek PA, Paylor R. Multiple autism-like behaviors in a novel transgenic mouse model. Behav Brain Res. 2011 Mar 17; 218(1):29-41. PMID: 21093492; PMCID: PMC3022332.
    50. Barkovich J, Hevner RF. Meningeal gyrations. Ann Neurol. 2010 Oct; 68(4):421-3. PMID: 20865763.
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    51. Juric-Sekhar G, Kapur RP, Glass IA, Murray ML, Parnell SE, Hevner RF. Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III. Acta Neuropathol. 2011 Apr; 121(4):545-54. PMID: 20857301; PMCID: PMC3059390.
    52. Koch H, Huh SE, Elsen FP, Carroll MS, Hodge RD, Bedogni F, Turner MS, Hevner RF, Ramirez JM. Prostaglandin E2-induced synaptic plasticity in neocortical networks of organotypic slice cultures. J Neurosci. 2010 Sep 01; 30(35):11678-87. PMID: 20810888; PMCID: PMC3842478.
    53. Bedogni F, Hodge RD, Elsen GE, Nelson BR, Daza RA, Beyer RP, Bammler TK, Rubenstein JL, Hevner RF. Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13129-34. PMID: 20615956; PMCID: PMC2919950.
    54. Rudzinski ER, Kapur RP, Hevner RF. Fetal akinesia deformation sequence with delayed skeletal muscle maturation and polymicrogyria: evidence for a hypoxic/ischemic pathogenesis. Pediatr Dev Pathol. 2010 May-Jun; 13(3):192-201. PMID: 19968489.
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    55. Bedogni F, Hodge RD, Nelson BR, Frederick EA, Shiba N, Daza RA, Hevner RF. Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology. Gene Expr Patterns. 2010 Jan; 10(1):9-15. PMID: 19948250; PMCID: PMC2818569.
    56. Brill MS, Ninkovic J, Winpenny E, Hodge RD, Ozen I, Yang R, Lepier A, Gascón S, Erdelyi F, Szabo G, Parras C, Guillemot F, Frotscher M, Berninger B, Hevner RF, Raineteau O, Götz M. Adult generation of glutamatergic olfactory bulb interneurons. Nat Neurosci. 2009 Dec; 12(12):1524-33. PMID: 19881504; PMCID: PMC2787799.
    57. Keene CD, Chang R, Stephen C, Nivison M, Nutt SE, Look A, Breyer RM, Horner PJ, Hevner R, Montine TJ. Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2. Am J Pathol. 2009 Jun; 174(6):2300-9. PMID: 19389932; PMCID: PMC2684194.
    58. Stubbs D, DeProto J, Nie K, Englund C, Mahmud I, Hevner R, Molnár Z. Neurovascular congruence during cerebral cortical development. Cereb Cortex. 2009 Jul; 19 Suppl 1:i32-41. PMID: 19386634; PMCID: PMC2693536.
    59. Cundiff P, Liu L, Wang Y, Zou J, Pan YW, Abel G, Duan X, Ming GL, Englund C, Hevner R, Xia Z. ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis. PLoS One. 2009; 4(4):e5204. PMID: 19365559; PMCID: PMC2664926.
    60. Iwata T, Hevner RF. Fibroblast growth factor signaling in development of the cerebral cortex. Dev Growth Differ. 2009 Apr; 51(3):299-323. PMID: 19379279.
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    61. Thomson RE, Kind PC, Graham NA, Etherson ML, Kennedy J, Fernandes AC, Marques CS, Hevner RF, Iwata T. Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex. Neural Dev. 2009 Feb 03; 4:4. PMID: 19192266; PMCID: PMC2661882.
    62. Kowalczyk T, Pontious A, Englund C, Daza RA, Bedogni F, Hodge R, Attardo A, Bell C, Huttner WB, Hevner RF. Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex. Cereb Cortex. 2009 Oct; 19(10):2439-50. PMID: 19168665; PMCID: PMC2742596.
    63. Keene CD, Chang RC, Leverenz JB, Kopyov O, Perlman S, Hevner RF, Born DE, Bird TD, Montine TJ. A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions. Acta Neuropathol. 2009 Mar; 117(3):329-38. PMID: 19057918; PMCID: PMC2676786.
    64. Jissendi-Tchofo P, Doherty D, McGillivray G, Hevner R, Shaw D, Ishak G, Leventer R, Barkovich AJ. Pontine tegmental cap dysplasia: MR imaging and diffusion tensor imaging features of impaired axonal navigation. AJNR Am J Neuroradiol. 2009 Jan; 30(1):113-9. PMID: 18842761; PMCID: PMC3919876.
    65. Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature. 2008 Sep 04; 455(7209):114-8. PMID: 18690213.
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    66. Hodge RD, Kowalczyk TD, Wolf SA, Encinas JM, Rippey C, Enikolopov G, Kempermann G, Hevner RF. Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output. J Neurosci. 2008 Apr 02; 28(14):3707-17. PMID: 18385329.
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    67. Pontious A, Kowalczyk T, Englund C, Hevner RF. Role of intermediate progenitor cells in cerebral cortex development. Dev Neurosci. 2008; 30(1-3):24-32. PMID: 18075251.
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    68. Daza RA, Englund C, Hevner RF. Organotypic slice culture of embryonic brain tissue. CSH Protoc. 2007 Dec 01; 2007:pdb.prot4914. PMID: 21357004.
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    69. Hevner RF. Progress on pontocerebellar hypoplasia. Acta Neuropathol. 2007 Oct; 114(4):401-2. PMID: 17710422.
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    70. Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, Hevner RF, Suda Y, Aizawa S, Ohshima T, Stoykova A, Tole S. A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat Neurosci. 2007 Sep; 10(9):1141-50. PMID: 17694053.
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    71. Dahlin A, Xia L, Kong W, Hevner R, Wang J. Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience. 2007 May 25; 146(3):1193-211. PMID: 17408864; PMCID: PMC2683847.
    72. Hevner RF. Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. J Neuropathol Exp Neurol. 2007 Feb; 66(2):101-9. PMID: 17278994.
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    73. Nemecek AN, Sviri G, Hevner R, Ghodke B, Britz GW. Dissecting aneurysm of the thoracic posterior spinal artery. Case illustration. J Neurosurg Spine. 2006 Dec; 5(6):555. PMID: 17176024.
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    74. Englund C, Kowalczyk T, Daza RA, Dagan A, Lau C, Rose MF, Hevner RF. Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter. J Neurosci. 2006 Sep 06; 26(36):9184-95. PMID: 16957075.
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    75. Quinn JC, Molinek M, Martynoga BS, Zaki PA, Faedo A, Bulfone A, Hevner RF, West JD, Price DJ. Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism. Dev Biol. 2007 Feb 01; 302(1):50-65. PMID: 16979618.
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    76. Hevner RF, Hodge RD, Daza RA, Englund C. Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus. Neurosci Res. 2006 Jul; 55(3):223-33. PMID: 16621079.
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    77. Fink AJ, Englund C, Daza RA, Pham D, Lau C, Nivison M, Kowalczyk T, Hevner RF. Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip. J Neurosci. 2006 Mar 15; 26(11):3066-76. PMID: 16540585.
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    78. Hevner RF. From radial glia to pyramidal-projection neuron: transcription factor cascades in cerebral cortex development. Mol Neurobiol. 2006 Feb; 33(1):33-50. PMID: 16388109.
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    79. Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner RF, Lax I, Okano H, Shibuya M, Schlessinger J, Gotoh N. Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):15983-8. PMID: 16239343; PMCID: PMC1276098.
    80. Hevner RF. The cerebral cortex malformation in thanatophoric dysplasia: neuropathology and pathogenesis. Acta Neuropathol. 2005 Sep; 110(3):208-21. PMID: 16133544.
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    81. Englund C, Alvord EC, Folkerth RD, Silbergeld D, Born DE, Small R, Hevner RF. NeuN expression correlates with reduced mitotic index of neoplastic cells in central neurocytomas. Neuropathol Appl Neurobiol. 2005 Aug; 31(4):429-38. PMID: 16008827.
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    82. Englund C, Folkerth RD, Born D, Lacy JM, Hevner RF. Aberrant neuronal-glial differentiation in Taylor-type focal cortical dysplasia (type IIA/B). Acta Neuropathol. 2005 May; 109(5):519-33. PMID: 15877232.
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    83. Englund C, Fink A, Lau C, Pham D, Daza RA, Bulfone A, Kowalczyk T, Hevner RF. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J Neurosci. 2005 Jan 05; 25(1):247-51. PMID: 15634788.
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    84. Wang TF, Ding CN, Wang GS, Luo SC, Lin YL, Ruan Y, Hevner R, Rubenstein JL, Hsueh YP. Identification of Tbr-1/CASK complex target genes in neurons. J Neurochem. 2004 Dec; 91(6):1483-92. PMID: 15584924.
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    85. Englund C, Silbergeld D, Alvord EC, Small R, Hevner RF. March 2004: a 24-year-old woman with bifrontal headaches. Brain Pathol. 2004 Jul; 14(3):341-3. PMID: 15446592.
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    86. Hevner RF, Daza RA, Englund C, Kohtz J, Fink A. Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration. Neuroscience. 2004; 124(3):605-18. PMID: 14980731.
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    87. Ueki T, Tanaka M, Yamashita K, Mikawa S, Qiu Z, Maragakis NJ, Hevner RF, Miura N, Sugimura H, Sato K. A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus. J Neurosci. 2003 Dec 17; 23(37):11732-40. PMID: 14684875.
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    88. Hevner R, Vilela M, Rostomily R, Cohrs R, Mahalingam R, Wellish M, Gilden DH. An unusual cause of trigeminal-distribution pain and tumour. Lancet Neurol. 2003 Sep; 2(9):567-71. PMID: 12941580.
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    89. Hevner RF, Neogi T, Englund C, Daza RA, Fink A. Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin. Brain Res Dev Brain Res. 2003 Mar 14; 141(1-2):39-53. PMID: 12644247.
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    90. Hevner RF, Daza RA, Rubenstein JL, Stunnenberg H, Olavarria JF, Englund C. Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons. Dev Neurosci. 2003 Mar-Aug; 25(2-4):139-51. PMID: 12966212.
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    91. Hevner RF, Miyashita-Lin E, Rubenstein JL. Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J Comp Neurol. 2002 May 20; 447(1):8-17. PMID: 11967891.
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    92. Simon EM, Hevner RF, Pinter JD, Clegg NJ, Delgado M, Kinsman SL, Hahn JS, Barkovich AJ. The middle interhemispheric variant of holoprosencephaly. AJNR Am J Neuroradiol. 2002 Jan; 23(1):151-6. PMID: 11827888.
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    93. Simon EM, Hevner RF, Pinter J, Clegg NJ, Delgado M, Kinsman SL, Hahn JS, Barkovich AJ. The dorsal cyst in holoprosencephaly and the role of the thalamus in its formation. Neuroradiology. 2001 Sep; 43(9):787-91. PMID: 11594433.
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    94. Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001 Feb; 29(2):353-66. PMID: 11239428.
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    95. Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL. Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons. Neuron. 2000 Dec; 28(3):727-40. PMID: 11163262.
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    96. Simon EM, Hevner R, Pinter JD, Clegg NJ, Miller VS, Kinsman SL, Hahn JS, Barkovich AJ. Assessment of the deep gray nuclei in holoprosencephaly. AJNR Am J Neuroradiol. 2000 Nov-Dec; 21(10):1955-61. PMID: 11110554.
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    97. Hevner RF. Development of connections in the human visual system during fetal mid-gestation: a DiI-tracing study. J Neuropathol Exp Neurol. 2000 May; 59(5):385-92. PMID: 10888368.
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    98. Barkovich AJ, Hevner R, Guerrini R. Syndromes of bilateral symmetrical polymicrogyria. AJNR Am J Neuroradiol. 1999 Nov-Dec; 20(10):1814-21. PMID: 10588102.
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    99. Rubenstein JL, Anderson S, Shi L, Miyashita-Lin E, Bulfone A, Hevner R. Genetic control of cortical regionalization and connectivity. Cereb Cortex. 1999 Sep; 9(6):524-32. PMID: 10498270.
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    100. Miyashita-Lin EM, Hevner R, Wassarman KM, Martinez S, Rubenstein JL. Early neocortical regionalization in the absence of thalamic innervation. Science. 1999 Aug 06; 285(5429):906-9. PMID: 10436162.
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    101. Shelbourne PF, Killeen N, Hevner RF, Johnston HM, Tecott L, Lewandoski M, Ennis M, Ramirez L, Li Z, Iannicola C, Littman DR, Myers RM. A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Hum Mol Genet. 1999 May; 8(5):763-74. PMID: 10196365.
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    102. Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S, Meneses J, Pedersen R, Axel R, Rubenstein JL. An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec; 21(6):1273-82. PMID: 9883721.
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    103. Hevner R, Sobel RA. November 1996--premature baby with lethargy and coma. Brain Pathol. 1997 Apr; 7(2):839-40. PMID: 9161734.
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    104. Hevner RF, Horoupian DS. Pena-Shokeir phenotype associated with bilateral opercular polymicrogyria. Pediatr Neurol. 1996 Nov; 15(4):348-51. PMID: 8972538.
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    105. Qiu M, Anderson S, Chen S, Meneses JJ, Hevner R, Kuwana E, Pedersen RA, Rubenstein JL. Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. Dev Biol. 1996 Aug 25; 178(1):174-8. PMID: 8812118.
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    106. Hevner RF, Liu S, Wong-Riley MT. A metabolic map of cytochrome oxidase in the rat brain: histochemical, densitometric and biochemical studies. Neuroscience. 1995 Mar; 65(2):313-42. PMID: 7777153.
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    107. Hevner RF, Liu S, Wong-Riley MT. An optimized method for determining cytochrome oxidase activity in brain tissue homogenates. J Neurosci Methods. 1993 Dec; 50(3):309-19. PMID: 8152242.
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    108. Hevner RF, Wong-Riley MT. Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionately regulated by functional activity in neurons. J Neurosci. 1993 May; 13(5):1805-19. PMID: 8386752.
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    109. Hevner RF, Wong-Riley MT. Neuronal expression of nuclear and mitochondrial genes for cytochrome oxidase (CO) subunits analyzed by in situ hybridization: comparison with CO activity and protein. J Neurosci. 1991 Jul; 11(7):1942-58. PMID: 1648602.
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