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    Susan Powell

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0804
    CA La Jolla 92093
    Phone619-471-9358
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      Collapse Overview

      Biography

      Dr. Powell received her BA degree with honors in Psychology from the University of North Carolina at Chapel Hill and her PhD in Psychobiology in 1999 from the University of Florida with support from an NIMH Predoctoral NRSA fellowship. She completed her postdoctoral training in psychopharmacology in the UCSD Psychiatry Department and was then appointed as an Assistant Project Scientist in 2003. Dr. Powell has been an Assistant Adjunct Professor of Psychiatry since 2007, and has been the principal investigator on research awards from NIMH and NARSAD.

      Research Interests

      Dr. Powell’s research broadly involves the behavioral effects of alterations in monoamine neurochemistry. She has been primarily studying the effects of early developmental manipulations on behavioral and neurobiological measures in rodents. In addition to research on the psychopharmacology and neurocircuitry of prepulse inhibition in rodents, Dr. Powell’s research explores possible prophylactic antipsychotic treatments in neurodevelopmental rodent models. Her research also involves basic studies on the behavioral effects of hallucinogens in rodents with the hope that these models will inform us about psychosis in humans.

      Clinical Focus

      The goal of the preclinical work is to develop new therapies for individuals with schizophrenia. Dr. Powell has partnered with local biotechnology companies to provide in vivo testing of putative therapeutic compounds for schizophrenia. By focusing on animal models of the developmental aspects of schizophrenia, it is to develop treatments for psychosis early in the course of the disease.


      Collapse Research 
      Collapse Research Activities and Funding
      Environmental contribution to neuronal-methylome dynamics in animal models of autism spectrum disorders
      NIH/NIEHS R01ES025585Aug 1, 2015 - Jun 30, 2020
      Role: Co-Principal Investigator
      Sensitive and Treatable Periods of Brain-Redox Imbalance in Schizophrenia
      NIH/NIMH R01MH091407Jul 19, 2010 - May 31, 2015
      Role: Co-Principal Investigator
      Models of Antipsychotic Prophylaxis for Schizophrenia
      NIH/NIMH R21MH068611Aug 8, 2003 - Jun 30, 2007
      Role: Principal Investigator
      STRESS RESPONSIVENESS IN ABNORMAL REPETITIVE BEHAVIOR
      NIH/NIMH F31MH012175Aug 24, 1998
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Deslauriers J, Powell S, Risbrough VB. Immune signaling mechanisms of PTSD risk and symptom development: insights from animal models. Curr Opin Behav Sci. 2017 Apr; 14:123-132. PMID: 28758144.
        View in: PubMed
      2. Deslauriers J, van Wijngaarde M, Geyer MA, Powell S, Risbrough VB. Effects of LPS-induced immune activation prior to trauma exposure on PTSD-like symptoms in mice. Behav Brain Res. 2017 Jan 31; 323:117-123. PMID: 28159589.
        View in: PubMed
      3. Khan A, de Jong LA, Kamenski ME, Higa KK, Lucero JD, Young JW, Margarita Behrens M, Powell S. Adolescent GBR12909 exposure induces oxidative stress, disrupts parvalbumin-positive interneurons, and leads to hyperactivity and impulsivity in adult mice. Neuroscience. 2016 Nov 24. PMID: 27890827.
        View in: PubMed
      4. Halberstadt AL, Hyun J, Ruderman MA, Powell S. Effects of the psychotomimetic benzomorphan N-allylnormetazocine (SKF 10,047) on prepulse inhibition of startle in mice. Pharmacol Biochem Behav. 2016 May 25. PMID: 27236030.
        View in: PubMed
      5. Halberstadt AL, Slepak N, Hyun J, Buell MR, Powell S. The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents. Psychopharmacology (Berl). 2016 Jan 13. PMID: 26758284.
        View in: PubMed
      6. Cope ZA, Powell S, Young JW. Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity. Genes Brain Behav. 2016 Jan; 15(1):27-44. PMID: 26667374.
        View in: PubMed
      7. Amitai N, Powell S, Weber M, Swerdlow NR, Young JW. Negative visuospatial priming in isolation-reared rats: Evidence of resistance to the disruptive effects of amphetamine. Cogn Affect Behav Neurosci. 2015 Dec; 15(4):901-14. PMID: 26220402.
        View in: PubMed
      8. Higa KK, Ji B, Buell MR, Risbrough VB, Powell S, Young JW, Geyer MA, Zhou X. Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice. Int J Neuropsychopharmacol. 2015; 18(11). PMID: 26037489.
        View in: PubMed
      9. Powell S, Khan A, Young JW, Scott CN, Buell MR, Caldwell S, Tsan E, de Jong LA, Acheson DT, Lucero J, Geyer MA, Behrens MM. Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats. Dev Neurosci. 2015; 37:253-62. PMID: 26022788.
        View in: PubMed
      10. Naviaux JC, Wang L, Li K, Bright AT, Alaynick WA, Williams KR, Powell S, Naviaux RK. Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model. Mol Autism. 2015; 6:1. PMID: 25705365.
        View in: PubMed
      11. Naviaux JC, Schuchbauer MA, Li K, Wang L, Risbrough VB, Powell S, Naviaux RK. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Transl Psychiatry. 2014; 4:e400. PMID: 24937094.
        View in: PubMed
      12. Amitai N, Young JW, Higa K, Sharp RF, Geyer MA, Powell S. Isolation rearing effects on probabilistic learning and cognitive flexibility in rats. Cogn Affect Behav Neurosci. 2014 Mar; 14(1):388-406. PMID: 23943516.
        View in: PubMed
      13. Liu XC, Holtze M, Powell S, Terrando N, Larsson MK, Persson A, Olsson SK, Orhan F, Kegel M, Asp L, Goiny M, Schwieler L, Engberg G, Karlsson H, Erhardt S. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment - Role of brain kynurenic acid. Brain Behav Immun. 2014 Feb; 36:80-9. PMID: 24140727.
        View in: PubMed
      14. Swerdlow NR, Light GA, Trim RS, Breier MR, Hines SR, Powell S. Forebrain gene expression predicts deficits in sensorimotor gating after isolation rearing in male rats. Behav Brain Res. 2013 Nov 15; 257:118-28. PMID: 24076151.
        View in: PubMed
      15. Swerdlow NR, Powell S, Breier MR, Hines SR, Light GA. Coupling of gene expression in medial prefrontal cortex and nucleus accumbens after neonatal ventral hippocampal lesions accompanies deficits in sensorimotor gating and auditory processing in rats. Neuropharmacology. 2013 Dec; 75:38-46. PMID: 23810830.
        View in: PubMed
      16. Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Le TP, Schuchbauer MA, Rogac M, Tang Q, Dugan LL, Powell S. Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS One. 2013; 8(3):e57380. PMID: 23516405.
        View in: PubMed
      17. Halberstadt AL, Powell S, Geyer MA. Role of the 5-HT2A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice. Neuropharmacology. 2013 Jul; 70:218-27. PMID: 23376711.
        View in: PubMed
      18. Swerdlow NR, Light GA, Breier MR, Shoemaker JM, Saint Marie RL, Neary AC, Geyer MA, Stevens KE, Powell S. Sensory and sensorimotor gating deficits after neonatal ventral hippocampal lesions in rats. Dev Neurosci. 2012; 34(2-3):240-9. PMID: 22572564.
        View in: PubMed
      19. Powell S, Weber M, Geyer MA. Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders. Curr Top Behav Neurosci. 2012; 12:251-318. PMID: 22367921.
        View in: PubMed
      20. Young JW, Powell S, Geyer MA. Mouse pharmacological models of cognitive disruption relevant to schizophrenia. Neuropharmacology. 2012 Mar; 62(3):1381-90. PMID: 21726569.
        View in: PubMed
      21. Young JW, Powell S, Scott CN, Zhou X, Geyer MA. The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding. Behav Brain Res. 2011 Sep 12; 222(1):183-92. PMID: 21458500.
        View in: PubMed
      22. Powell S, Sejnowski TJ, Behrens MM. Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia. Neuropharmacology. 2012 Mar; 62(3):1322-31. PMID: 21315745.
        View in: PubMed
      23. Halberstadt AL, Lehmann-Masten VD, Geyer MA, Powell S. Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice. Psychopharmacology (Berl). 2011 May; 215(1):81-92. PMID: 21153406.
        View in: PubMed
      24. Halberstadt AL, Koedood L, Powell S, Geyer MA. Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J Psychopharmacol. 2011 Nov; 25(11):1548-61. PMID: 21148021.
        View in: PubMed
      25. Gresack J, Powell S, Geyer M, Poore MS, Coste S, Risbrough V. CRF2 null mutation increases sensitivity to isolation rearing effects on locomotor activity in mice. Neuropeptides. 2010 Aug; 44(4):349-53. PMID: 20466421.
        View in: PubMed
      26. Young JW, Powell S, Geyer MA, Jeste DV, Risbrough VB. The mouse attentional-set-shifting task: a method for assaying successful cognitive aging? Cogn Affect Behav Neurosci. 2010 May; 10(2):243-51. PMID: 20498348.
        View in: PubMed
      27. Gresack JE, Risbrough VB, Scott CN, Coste S, Stenzel-Poore M, Geyer MA, Powell S. Isolation rearing-induced deficits in contextual fear learning do not require CRF(2) receptors. Behav Brain Res. 2010 May 1; 209(1):80-4. PMID: 20097235.
        View in: PubMed
      28. Powell S. Models of neurodevelopmental abnormalities in schizophrenia. Curr Top Behav Neurosci. 2010; 4:435-81. PMID: 21312409.
        View in: PubMed
      29. Asp L, Holtze M, Powell S, Karlsson H, Erhardt S. Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice. Int J Neuropsychopharmacol. 2010 May; 13(4):475-85. PMID: 19607757.
        View in: PubMed
      30. Ruderman MA, Powell S, Geyer MA. A Kappa Opioid Model of Atypical Altered Consciousness and Psychosis: U50488, DOI, AC90179 Effects on Prepulse Inhibition and Locomotion in Mice. J Young Investig. 2009 Jul 1; 19(13):1-7. PMID: 25346645.
        View in: PubMed
      31. Powell S, Zhou X, Geyer MA. Prepulse inhibition and genetic mouse models of schizophrenia. Behav Brain Res. 2009 Dec 7; 204(2):282-94. PMID: 19397931.
        View in: PubMed
      32. Halberstadt AL, van der Heijden I, Ruderman MA, Risbrough VB, Gingrich JA, Geyer MA, Powell S. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul; 34(8):1958-67. PMID: 19322172.
        View in: PubMed
      33. Young JW, Powell S, Risbrough V, Marston HM, Geyer MA. Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther. 2009 May; 122(2):150-202. PMID: 19269307.
        View in: PubMed
      34. Powell S, Young JW, Ong JC, Caron MG, Geyer MA. Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. Behav Pharmacol. 2008 Sep; 19(5-6):562-5. PMID: 18690110.
        View in: PubMed
      35. Doherty JM, Masten VL, Powell S, Ralph RJ, Klamer D, Low MJ, Geyer MA. Contributions of dopamine D1, D2, and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice. Neuropsychopharmacology. 2008 Oct; 33(11):2648-56. PMID: 18075489.
        View in: PubMed
      36. Powell S, Geyer MA. Overview of animal models of schizophrenia. Curr Protoc Neurosci. 2007 Apr; Chapter 9:Unit 9.24. PMID: 18428667.
        View in: PubMed
      37. Barr AM, Powell S, Markou A, Geyer MA. Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology. 2006 Sep; 51(3):457-65. PMID: 16762376.
        View in: PubMed
      38. Vanover KE, Weiner DM, Makhay M, Veinbergs I, Gardell LR, Lameh J, Del Tredici AL, Piu F, Schiffer HH, Ott TR, Burstein ES, Uldam AK, Thygesen MB, Schlienger N, Andersson CM, Son TY, Harvey SC, Powell S, Geyer MA, Tolf BR, Brann MR, Davis RE. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May; 317(2):910-8. PMID: 16469866.
        View in: PubMed
      39. Varty GB, Powell S, Lehmann-Masten V, Buell MR, Geyer MA. Isolation rearing of mice induces deficits in prepulse inhibition of the startle response. Behav Brain Res. 2006 Apr 25; 169(1):162-7. PMID: 16406103.
        View in: PubMed
      40. Powell S, Palomo J, Carasso BS, Bakshi VP, Geyer MA. Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. Psychopharmacology (Berl). 2005 Jul; 180(3):491-500. PMID: 15719216.
        View in: PubMed
      41. Harte MK, Powell S, Reynolds LM, Swerdlow NR, Geyer MA, Reynolds GP. Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation. Biol Psychiatry. 2004 Aug 15; 56(4):296-9. PMID: 15312819.
        View in: PubMed
      42. Powell S, Geyer MA, Gallagher D, Paulus MP. The balance between approach and avoidance behaviors in a novel object exploration paradigm in mice. Behav Brain Res. 2004 Jul 9; 152(2):341-9. PMID: 15196802.
        View in: PubMed
      43. Powell S, Lehmann-Masten VD, Paulus MP, Gainetdinov RR, Caron MG, Geyer MA. MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice. Psychopharmacology (Berl). 2004 May; 173(3-4):310-7. PMID: 14747902.
        View in: PubMed
      44. Powell S, Paulus MP, Hartman DS, Godel T, Geyer MA. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar; 44(4):473-81. PMID: 12646284.
        View in: PubMed
      45. Powell S, Geyer MA, Preece MA, Pitcher LK, Reynolds GP, Swerdlow NR. Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats. Neuroscience. 2003; 119(1):233-40. PMID: 12763084.
        View in: PubMed
      46. Powell S, Swerdlow NR, Pitcher LK, Geyer MA. Isolation rearing-induced deficits in prepulse inhibition and locomotor habituation are not potentiated by water deprivation. Physiol Behav. 2002 Sep; 77(1):55-64. PMID: 12213502.
        View in: PubMed
      47. Powell S, Geyer MA. Developmental markers of psychiatric disorders as identified by sensorimotor gating. Neurotox Res. 2002 Aug-Sep; 4(5-6):489-502. PMID: 12754162.
        View in: PubMed
      48. Presti MF, Powell S, Lewis MH. Dissociation between spontaneously emitted and apomorphine-induced stereotypy in Peromyscus maniculatus bairdii. Physiol Behav. 2002 Mar; 75(3):347-53. PMID: 11897261.
        View in: PubMed
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