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P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery. Pancreas. 2010 May; 39(4):436-43.
Omori K, Todorov I, Shintaku J, Rawson J, Al-Abdullah IH, Higgins LS, Medicherla S, Kandeel F, Mullen Y. PMID: 20084046; PMCID: PMC2860020.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig. J Inflamm Res. 2010; 3:9-16.
Medicherla S, Ma JY, Reddy M, Esikova I, Kerr I, Movius F, Higgins LS, Protter AA. PMID: 22096353; PMCID: PMC3218738.
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PubMed Mentions:
4
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p38 MAPK inhibition reduces diabetes-induced impairment of wound healing. Diabetes Metab Syndr Obes. 2009 Jun 23; 2:91-100.
Medicherla S, Wadsworth S, Cullen B, Silcock D, Ma JY, Mangadu R, Kerr I, Chakravarty S, Luedtke GL, Dugar S, Protter AA, Higgins LS. PMID: 21437122; PMCID: PMC3048002.
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PubMed Mentions:
16
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Analgesic effects of p38 kinase inhibitor treatment on bone fracture healing. Pain. 2009 Mar; 142(1-2):116-26.
Cottrell JA, Meyenhofer M, Medicherla S, Higgins L, O'Connor JP. PMID: 19167815.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma. J Asthma Allergy. 2008 Nov 16; 1:31-44.
Ma JY, Medicherla S, Kerr I, Mangadu R, Protter AA, Higgins LS. PMID: 21436983; PMCID: PMC3121334.
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9
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p38alpha-selective MAP kinase inhibitor reduces tumor growth in mouse xenograft models of multiple myeloma. Anticancer Res. 2008 Nov-Dec; 28(6A):3827-33.
Medicherla S, Reddy M, Ying J, Navas TA, Li L, Nguyen AN, Kerr I, Hanjarappa N, Protter AA, Higgins LS. PMID: 19189670.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacol Biochem Behav. 2008 Oct; 90(4):664-75.
Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. PMID: 18584857.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation. Eur J Pharmacol. 2008 Dec 14; 600(1-3):117-22.
Williams AS, Issa R, Durham A, Leung SY, Kapoun A, Medicherla S, Higgins LS, Adcock IM, Chung KF. PMID: 18926814.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood. 2008 Oct 15; 112(8):3434-43.
Zhou L, Nguyen AN, Sohal D, Ying Ma J, Pahanish P, Gundabolu K, Hayman J, Chubak A, Mo Y, Bhagat TD, Das B, Kapoun AM, Navas TA, Parmar S, Kambhampati S, Pellagatti A, Braunchweig I, Zhang Y, Wickrema A, Medicherla S, Boultwood J, Platanias LC, Higgins LS, List AF, Bitzer M, Verma A. PMID: 18474728; PMCID: PMC2569182.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg Med Chem Lett. 2008 Apr 01; 18(7):2404-8.
Mavunkel B, Xu YJ, Goyal B, Lim D, Lu Q, Chen Z, Wang DX, Higaki J, Chakraborty I, Liclican A, Sideris S, Laney M, Delling U, Catalano R, Higgins LS, Wang H, Wang J, Feng Y, Dugar S, Levy DE. PMID: 18334293.
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10 Fields:
Translation:
Cells
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Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension. Am J Respir Crit Care Med. 2008 Apr 15; 177(8):896-905.
Zaiman AL, Podowski M, Medicherla S, Gordy K, Xu F, Zhen L, Shimoda LA, Neptune E, Higgins L, Murphy A, Chakravarty S, Protter A, Sehgal PB, Champion HC, Tuder RM. PMID: 18202349; PMCID: PMC2292828.
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74 Fields:
Translation:
AnimalsCells
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Pharmacological properties of SD-282 - an alpha-isoform selective inhibitor for p38 MAP kinase. Pharmacology. 2008; 81(3):204-20.
Koppelman B, Webb HK, Medicherla S, Almirez R, Feng Y, Chavez JC, Mao CP, Nguyen A, Liu YW, Kapoun AM, Muiru G, Huang YA, Dugar S, Mavunkel BJ, Lim DW, Chakravarty S, Luedtke G, Protter AA, Higgins LS. PMID: 18176091.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation. J Pharmacol Exp Ther. 2008 Mar; 324(3):921-9.
Medicherla S, Fitzgerald MF, Spicer D, Woodman P, Ma JY, Kapoun AM, Chakravarty S, Dugar S, Protter AA, Higgins LS. PMID: 18056868.
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PubMed Mentions:
31 Fields:
Translation:
Animals
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Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment. Anticancer Res. 2007 Nov-Dec; 27(6B):4149-57.
Medicherla S, Li L, Ma JY, Kapoun AM, Gaspar NJ, Liu YW, Mangadu R, O'Young G, Protter AA, Schreiner GF, Wong DH, Higgins LS. PMID: 18229422.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model. J Periodontol. 2007 Oct; 78(10):1992-8.
Rogers JE, Li F, Coatney DD, Otremba J, Kriegl JM, Protter TA, Higgins LS, Medicherla S, Kirkwood KL. PMID: 18062121.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model. Neuro Oncol. 2007 Jul; 9(3):259-70.
Tran TT, Uhl M, Ma JY, Janssen L, Sriram V, Aulwurm S, Kerr I, Lam A, Webb HK, Kapoun AM, Kizer DE, McEnroe G, Hart B, Axon J, Murphy A, Chakravarty S, Dugar S, Protter AA, Higgins LS, Wick W, Weller M, Wong DH. PMID: 17522330; PMCID: PMC1907409.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Inhibition of p38alpha mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma. Cancer Res. 2007 May 15; 67(10):4572-7.
Vanderkerken K, Medicherla S, Coulton L, De Raeve H, Willems A, Lawson M, Van Camp B, Protter AA, Higgins LS, Menu E, Croucher PI. PMID: 17495322.
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15 Fields:
Translation:
AnimalsCells
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Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance. Cancer Res. 2007 May 01; 67(9):4459-66.
Small GW, Shi YY, Higgins LS, Orlowski RZ. PMID: 17483361.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness. Mol Pharmacol. 2007 Jul; 72(1):152-61.
Gaspar NJ, Li L, Kapoun AM, Medicherla S, Reddy M, Li G, O'Young G, Quon D, Henson M, Damm DL, Muiru GT, Murphy A, Higgins LS, Chakravarty S, Wong DH. PMID: 17400764.
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PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss. J Pharmacol Exp Ther. 2007 Jan; 320(1):56-63.
Kirkwood KL, Li F, Rogers JE, Otremba J, Coatney DD, Kreider JM, D'Silva NJ, Chakravarty S, Dugar S, Higgins LS, Protter AA, Medicherla S. PMID: 17041006.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood. 2006 Dec 15; 108(13):4170-7.
Navas TA, Mohindru M, Estes M, Ma JY, Sokol L, Pahanish P, Parmar S, Haghnazari E, Zhou L, Collins R, Kerr I, Nguyen AN, Xu Y, Platanias LC, List AA, Higgins LS, Verma A. PMID: 16940419; PMCID: PMC1895446.
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PubMed Mentions:
62 Fields:
Translation:
HumansCellsCTClinical Trials
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Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Res. 2006 Jul 01; 66(13):6763-71.
Giafis N, Katsoulidis E, Sassano A, Tallman MS, Higgins LS, Nebreda AR, Davis RJ, Platanias LC. PMID: 16818652.
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40 Fields:
Translation:
HumansAnimalsCells
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Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness. Eur J Pharmacol. 2006 Aug 21; 544(1-3):160-7.
Nath P, Leung SY, Williams A, Noble A, Chakravarty SD, Luedtke GR, Medicherla S, Higgins LS, Protter A, Chung KF. PMID: 16843456.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression. Mol Pharmacol. 2006 Aug; 70(2):518-31.
Kapoun AM, Gaspar NJ, Wang Y, Damm D, Liu YW, O'young G, Quon D, Lam A, Munson K, Tran TT, Ma JY, Murphy A, Dugar S, Chakravarty S, Protter AA, Wen FQ, Liu X, Rennard SI, Higgins LS. PMID: 16707625.
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29 Fields:
Translation:
HumansCells
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Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp Cell Res. 2006 Jun 10; 312(10):1909-23.
Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS. PMID: 16600214.
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21 Fields:
Translation:
HumansAnimalsCells
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p38 Inhibition attenuates the pro-inflammatory response to C-reactive protein by human peripheral blood mononuclear cells. J Mol Cell Cardiol. 2004 Dec; 37(6):1111-4.
Lim MY, Wang H, Kapoun AM, O'connell M, O'Young G, Brauer HA, Luedtke GR, Chakravarty S, Dugar S, Schreiner GS, Protter AA, Higgins LS. PMID: 15572041.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor. Am J Respir Crit Care Med. 2005 Apr 15; 171(8):889-98.
Bonniaud P, Margetts PJ, Kolb M, Schroeder JA, Kapoun AM, Damm D, Murphy A, Chakravarty S, Dugar S, Higgins L, Protter AA, Gauldie J. PMID: 15563636.
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PubMed Mentions:
92 Fields:
Translation:
AnimalsCells
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Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin Cancer Res. 2004 Nov 15; 10(22):7540-6.
Hayashi T, Hideshima T, Nguyen AN, Munoz O, Podar K, Hamasaki M, Ishitsuka K, Yasui H, Richardson P, Chakravarty S, Murphy A, Chauhan D, Higgins LS, Anderson KC. PMID: 15569984.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 Nov 01; 64(21):7954-61.
Uhl M, Aulwurm S, Wischhusen J, Weiler M, Ma JY, Almirez R, Mangadu R, Liu YW, Platten M, Herrlinger U, Murphy A, Wong DH, Wick W, Higgins LS, Weller M. PMID: 15520202.
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PubMed Mentions:
173 Fields:
Translation:
HumansAnimalsCells
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Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res. 2004 Aug 01; 64(15):5200-11.
Subramanian G, Schwarz RE, Higgins L, McEnroe G, Chakravarty S, Dugar S, Reiss M. PMID: 15289325.
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56 Fields:
Translation:
HumansCells
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Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling. Biochem Pharmacol. 2004 Jul 01; 68(1):41-50.
Ge R, Rajeev V, Subramanian G, Reiss KA, Liu D, Higgins L, Joly A, Dugar S, Chakravarty J, Henson M, McEnroe G, Schreiner G, Reiss M. PMID: 15183116.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1610-5.
Koistinaho M, Kettunen MI, Goldsteins G, Keinänen R, Salminen A, Ort M, Bures J, Liu D, Kauppinen RA, Higgins LS, Koistinaho J. PMID: 11818564; PMCID: PMC122238.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells