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    Philip Gordts

    TitleAssistant Researcher
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0687
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Awards and Honors
      European Lipoprotein Club2007  - 2008Young Investigator Award
      International Atherosclerosis Society2006Young Investigator Award
      European Union2011  - 2015Marie Curie International outgoing fellowship
      University of California, San Diego2014UCSD Chancellor’s Award for Outstanding Postdoctoral Scholar
      American Heart Association2015  - 2017Beginning Grant In-Aid Award
      Journal of Lipid Research 2016Junior Investigator Award

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamil K, Moremen KW, Sarrazin S, Gordts P, Dozier LE, Patrick GN, Tor Y, Esko JD. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Aug 12. PMID: 28958576.
        View in: PubMed
      2. Yeang C, Gordts P, Tsimikas S. Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List. Circ Res. 2017 Mar 31; 120(7):1050-1052. PMID: 28360338.
        View in: PubMed
      3. Moriarty PM, Varvel SA, Gordts P, McConnell JP, Tsimikas S. Lipoprotein(a) Mass Levels Increase Significantly According to APOE Genotype: An Analysis of 431?239 Patients. Arterioscler Thromb Vasc Biol. 2017 Mar; 37(3):580-588. PMID: 28062489.
        View in: PubMed
      4. Gordts P, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 Aug 01; 126(8):2855-66. PMID: 27400128; PMCID: PMC4966320 [Available on 11/01/16].
      5. Khalid O, Vera MU, Gordts P, Ellinwood NM, Schwartz PH, Dickson PI, Esko JD, Wang RY. Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. PLoS One. 2016; 11(3):e0150850. PMID: 26986213; PMCID: PMC4795702.
      6. Ramms B, Gordts P. Dietary nitrate struggles in atherosclerosis. Atherosclerosis. 2016 Feb; 245:71-3. PMID: 26708286.
        View in: PubMed
      7. Weiss RJ, Gordts P, Le D, Xu D, Esko JD, Tor Y. Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. PMID: 28133533.
        View in: PubMed
      8. Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts P, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagiroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015 May; 47(5):528-34. PMID: 25848753; PMCID: PMC4414867.
      9. Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts P, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015 Mar 10; 6:6356. PMID: 25754609; PMCID: PMC4366535.
      10. Mooij HL, Bernelot Moens SJ, Gordts P, Stanford KI, Foley EM, van den Boogert MA, Witjes JJ, Hassing HC, Tanck MW, van de Sande MA, Levels JH, Kastelein JJ, Stroes ES, Dallinga-Thie GM, Esko JD, Nieuwdorp M. Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res. 2015 Mar; 56(3):665-73. PMID: 25568062; PMCID: PMC4340313.
      11. Gordts P, Esko JD. Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-ß. Cytokine. 2015 Mar; 72(1):118-9. PMID: 25573804.
        View in: PubMed
      12. Gordts P, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-26. PMID: 25440058; PMCID: PMC4254584.
      13. Foley EM, Gordts P, Stanford KI, Gonzales JC, Lawrence R, Stoddard N, Esko JD. Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2065-74. PMID: 23846497; PMCID: PMC3821931.
      14. Gonzales JC, Gordts P, Foley EM, Esko JD. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest. 2013 Jun; 123(6):2742-51. PMID: 23676495; PMCID: PMC3668842.
      15. Lamanna WC, Lawrence R, Sarrazin S, Lameda-Diaz C, Gordts P, Moremen KW, Esko JD. A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 2012 Oct 19; 287(43):36283-90. PMID: 22952226; PMCID: PMC3476295.
      16. Christoffersen C, Benn M, Christensen PM, Gordts P, Roebroek AJ, Frikke-Schmidt R, Tybjaerg-Hansen A, Dahlbäck B, Nielsen LB. The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles. J Lipid Res. 2012 Oct; 53(10):2198-204. PMID: 22826357; PMCID: PMC3435552.
      17. Gordts P, Bartelt A, Nilsson SK, Annaert W, Christoffersen C, Nielsen LB, Heeren J, Roebroek AJ. Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice. PLoS One. 2012; 7(6):e38330. PMID: 22701627; PMCID: PMC3368875.
      18. Deng Y, Foley EM, Gonzales JC, Gordts P, Li Y, Esko JD. Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance. Hepatology. 2012 Jan; 55(1):277-86. PMID: 21898481; PMCID: PMC3245353.
      19. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts P, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J. Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011 Feb; 17(2):200-5. PMID: 21258337.
        View in: PubMed
      20. Roebroek AJ, Gordts P, Reekmans S. Knock-in approaches. Methods Mol Biol. 2011; 693:257-75. PMID: 21080285.
        View in: PubMed
      21. Roebroek AJ, Gordts P, Reekmans S. Generation of a series of knock-in alleles using RMCE in ES cells. Methods Mol Biol. 2011; 693:277-81. PMID: 21080286.
        View in: PubMed
      22. Christoffersen C, Pedersen TX, Gordts P, Roebroek AJ, Dahlbäck B, Nielsen LB. Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis. Circ Res. 2010 May 28; 106(10):1624-34. PMID: 20360257.
        View in: PubMed
      23. Reekmans SM, Pflanzner T, Gordts P, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik CU. Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cell Mol Life Sci. 2010 Jan; 67(1):135-45. PMID: 19856143.
        View in: PubMed
      24. Gordts P, Reekmans S, Lauwers A, Van Dongen A, Verbeek L, Roebroek AJ. Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Sep; 29(9):1258-64. PMID: 19667105.
        View in: PubMed
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