Robert Tukey

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of Iowa
    B.S.University of Minnesota

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Lifelong Triclosan Exposure and Fatty Liver Disease
    NIH R21ES031849Jun 16, 2020 - May 31, 2022
    Role: Principal Investigator
    Novel regulatory events that control expression of the UGT1A1 gene
    NIH R01GM126074Jan 15, 2018 - Nov 30, 2021
    Role: Principal Investigator
    Neonatal hyperbilirubinemia in a humanized UGT1 animal model
    NIH R01GM100481Mar 15, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Co-repressors SMRT and NCoR1 regulate UGT1A1 gene expression
    NIH R01GM086713Sep 1, 2009 - Apr 30, 2019
    Role: Principal Investigator
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Principal Investigator
    NIH R01CA079834Dec 17, 1998 - Nov 30, 2002
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Jul 1, 1996 - Apr 30, 2024
    Role: Co-Investigator
    Regulated Properties of the Human UGT1A1 Gene.
    NIH R01GM049135Apr 1, 1994 - Nov 30, 2007
    Role: Principal Investigator
    NIH R01GM036590Apr 1, 1986 - Jun 30, 2001
    Role: Principal Investigator
    NIH R01CA037139Apr 1, 1984 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. Sci Rep. 2021 05 27; 11(1):11107. van der Schoor LWE, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valášková P, Jašprová J, Struik D, Bloks VW, Chen S, Schreuder AB, Vítek L, Tukey RH, Jonker JW. PMID: 34045606.
      View in: PubMed   Mentions:    Fields:    
    2. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31259-31266. Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. PMID: 33229553.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos. 2021 01; 49(1):12-19. Weber AA, Mennillo E, Yang X, van der Schoor LWE, Jonker JW, Chen S, Tukey RH. PMID: 33154041.
      View in: PubMed   Mentions:    Fields:    
    4. Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice. Drug Metab Dispos. 2020 04; 48(4):255-263. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. PMID: 31980500; PMCID: PMC7065491.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in hUGT1 Mice. Drug Metab Dispos. 2020 01; 48(1):25-30. Paszek M, Tukey RH. PMID: 31704714.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos. 2018 11; 46(11):1745-1755. Chen S, Tukey RH. PMID: 30093417.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    7. Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet. 2018 Feb; 33(1):9-16. Fujiwara R, Yoda E, Tukey RH. PMID: 29079228.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Severe Neonatal Hyperbilirubinemia in Crigler-Najjar Syndrome Model Mice Can Be Reversed With Zinc Protoporphyrin. Hepatol Commun. 2017 Oct; 1(8):792-802. Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. PMID: 29399656.
      View in: PubMed   Mentions:
    9. Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017 07; 45(7):748-754. Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. PMID: 28468837.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    10. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 2017 04 19; 7:46489. Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH. PMID: 28422158.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    11. Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia. Mol Pharmacol. 2017 May; 91(5):545-553. Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 28283555.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    12. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    13. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 07; 37(7):863-872. Hirashima R, Itoh T, Tukey RH, Fujiwara R. PMID: 28138970.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E244-E252. Hinds TD, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. PMID: 28096081.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    15. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 2016 09; 90(3):265-74. Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R. PMID: 27413119.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    16. Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46. Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. PMID: 27060662.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 06; 64(6):1315-26. Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. PMID: 26921690.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    18. Triclosan: A Widespread Environmental Toxicant with Many Biological Effects. Annu Rev Pharmacol Toxicol. 2016; 56:251-72. Yueh MF, Tukey RH. PMID: 26738475.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    19. Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biol Pharm Bull. 2016; 39(10):1604-1610. Mitsugi R, Sumida K, Fujie Y, Tukey RH, Itoh T, Fujiwara R. PMID: 27725437.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia. Mol Pharmacol. 2016 Jan; 89(1):84-93. Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. PMID: 26480925.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    21. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):63-76.e5. Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. PMID: 26807433.
      View in: PubMed   Mentions: 3     Fields:    
    22. Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015 Nov 15; 289(1):124-32. Fujiwara R, Maruo Y, Chen S, Tukey RH. PMID: 26342858.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    23. The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health. Environ Health Perspect. 2015 Oct; 123(10):909-18. Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH. PMID: 25978799.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    24. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos. 2015 Jul; 43(7):1071-6. Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. PMID: 25953521.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet. 2015 Aug; 30(4):269-75. Sakamoto M, Itoh T, Tukey RH, Fujiwara R. PMID: 26210671.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    27. Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia. Sci Rep. 2014 Sep 11; 4:6343. Aoshima N, Fujie Y, Itoh T, Tukey RH, Fujiwara R. PMID: 25209391.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    28. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos. 2014 Jul; 42(7):1146-52. Kutsuno Y, Itoh T, Tukey RH, Fujiwara R. PMID: 24764149.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    29. Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice. J Pediatr. 2014 Jul; 165(1):36-41.e1. Maruo Y, Morioka Y, Fujito H, Nakahara S, Yanagi T, Matsui K, Mori A, Sato H, Tukey RH, Takeuchi Y. PMID: 24650397.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014 Feb 21; 289(8):4699-709. Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 24403077.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    31. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. PMID: 24191041.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    32. Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia. Sci Rep. 2013 Oct 09; 3:2903. Shibuya A, Itoh T, Tukey RH, Fujiwara R. PMID: 24104695.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    33. Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes. Pharmacol Res Perspect. 2013 Oct; 1(1):e00002. Kutsuno Y, Sumida K, Itoh T, Tukey RH, Fujiwara R. PMID: 25505556.
      View in: PubMed   Mentions: 12     Fields:    
    34. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol Pharmacol. 2013 Nov; 84(5):679-86. Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R. PMID: 23950218.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    35. Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys. 2013 Jul 15; 535(2):143-9. Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS. PMID: 23562620.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    36. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets. 2012 Nov; 16(11):1075-83. Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. PMID: 22913318.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    37. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 2012; 7(6):e37705. Yueh MF, Li T, Evans RM, Hammock B, Tukey RH. PMID: 22761658.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    38. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67. Chen S, Yueh MF, Evans RM, Tukey RH. PMID: 22371261.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    39. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    40. Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited. Gastroenterology. 2011 May; 140(5):1692-3. Vogel A, Ockenga J, Tukey RH, Manns MP, Strassburg CP. PMID: 21440586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011 Jun; 79(6):1053-60. Yueh MF, Mellon PL, Tukey RH. PMID: 21415305.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5024-9. Fujiwara R, Nguyen N, Chen S, Tukey RH. PMID: 20194756.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    43. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos. 2010 May; 38(5):879-86. Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. PMID: 20124398.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    44. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov; 39(11):826-35. Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP. PMID: 19845433.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem. 2009 Jun 12; 284(24):16541-16552. Savas Ü, Machemer DEW, Hsu MH, Gaynor P, Lasker JM, Tukey RH, Johnson EF. PMID: 19366684.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    46. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. J Steroid Biochem Mol Biol. 2008 Apr; 109(3-5):247-53. Chouinard S, Yueh MF, Tukey RH, Giton F, Fiet J, Pelletier G, Barbier O, Bélanger A. PMID: 18467088.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    47. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11. Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. PMID: 18180294.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    48. The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology. 2007 Feb; 45(2):349-60. Bonzo JA, Bélanger A, Tukey RH. PMID: 17256720.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    49. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem. 2007 Mar 23; 282(12):8749-58. Yueh MF, Tukey RH. PMID: 17259171.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    50. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect. 2007 Apr; 115(4):564-71. Pezzoli K, Tukey R, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman M. PMID: 17450225.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    51. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007 Feb 16; 282(7):4821-4829. Operaña TN, Tukey RH. PMID: 17179145.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    52. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar; 35(3):419-27. Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. PMID: 17151188.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    53. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci. 2007 Jan; 95(1):98-107. Operaña TN, Nguyen N, Chen S, Beaton D, Tukey RH. PMID: 17065433.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    54. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology. 2006 Aug; 44(2):368-78. Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Bélanger J, Kaeding J, Staels B, Caron P, Tukey RH, Barbier O. PMID: 16871576.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    55. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11; 280(45):37547-57. Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. PMID: 16155002.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    56. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci. 2005 Sep; 87(1):27-37. Machemer DE, Tukey RH. PMID: 15947024.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    57. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol. 2005 Apr; 67(4):1247-56. Bonzo JA, Chen S, Galijatovic A, Tukey RH. PMID: 15630080.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    58. The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1. Methods Enzymol. 2005; 400:75-91. Yueh MF, Bonzo JA, Tukey RH. PMID: 16399344.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    59. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem. 2005 Feb 11; 280(6):4350-9. Chen S, Operaña T, Bonzo J, Nguyen N, Tukey RH. PMID: 15572374.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    60. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. PMID: 15037607.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    61. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4150-5. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM. PMID: 12644700.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    62. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. PMID: 12637498.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    63. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 2003 Apr 25; 278(17):15001-6. Yueh MF, Huang YH, Hiller A, Chen S, Nguyen N, Tukey RH. PMID: 12566446.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    64. Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity. Mol Pharmacol. 2002 Sep; 62(3):446-50. Tukey RH, Strassburg CP, Mackenzie PI. PMID: 12181419.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    65. Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer. Z Gastroenterol. 2002 Jul; 40(7):497-502. Vogel A, Ockenga J, Ehmer U, Barut A, Kramer FJ, Tukey RH, Manns MP, Strassburg CP. PMID: 12122597.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    66. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut. 2002 Jun; 50(6):851-6. Strassburg CP, Vogel A, Kneip S, Tukey RH, Manns MP. PMID: 12010889.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    67. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenetics. 2002 Jun; 12(4):287-97. Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH. PMID: 12042666.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    68. Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue. Mol Pharmacol. 2002 Feb; 61(2):320-5. Strassburg A, Strassburg CP, Manns MP, Tukey RH. PMID: 11809856.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    69. Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut. 2002 Feb; 50(2):259-65. Strassburg CP, Strassburg A, Kneip S, Barut A, Tukey RH, Rodeck B, Manns MP. PMID: 11788570.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    70. Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. Gastroenterology. 2001 Nov; 121(5):1136-44. Vogel A, Kneip S, Barut A, Ehmer U, Tukey RH, Manns MP, Strassburg CP. PMID: 11677206.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    71. Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7. J Hepatol. 2001 Jun; 34(6):865-72. Strassburg CP, Barut A, Obermayer-Straub P, Li Q, Nguyen N, Tukey RH, Manns MP. PMID: 11451170.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    72. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis. 2001 Jun; 22(6):943-50. Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH. PMID: 11375903.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    73. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol. 2001 Mar; 59(3):405-14. Tukey RH, Strassburg CP. PMID: 11179432.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    74. Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes. Br J Pharmacol. 2001 Mar; 132(5):1027-34. Shipkova M, Strassburg CP, Braun F, Streit F, Gröne HJ, Armstrong VW, Tukey RH, Oellerich M, Wieland E. PMID: 11226133.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    75. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem. 2000 Nov 17; 275(46):36164-71. Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP. PMID: 10748067.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    76. Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene. Mol Pharmacol. 2000 Jul; 58(1):89-97. Li Q, Lamb G, Tukey RH. PMID: 10860930.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    77. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000; 40:581-616. Tukey RH, Strassburg CP. PMID: 10836148.
      View in: PubMed   Mentions: 284     Fields:    Translation:Humans
    78. Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. Carcinogenesis. 1999 Jun; 20(6):1107-14. Nowell SA, Massengill JS, Williams S, Radominska-Pandya A, Tephly TR, Cheng Z, Strassburg CP, Tukey RH, MacLeod SL, Lang NP, Kadlubar FF. PMID: 10357796.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    79. Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May; 27(5):605-12. Hiller A, Nguyen N, Strassburg CP, Li Q, Jainta H, Pechstein B, Ruus P, Engel J, Tukey RH, Kronbach T. PMID: 10220490.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    80. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Biochem J. 1999 Mar 01; 338 ( Pt 2):489-98. Strassburg CP, Strassburg A, Nguyen N, Li Q, Manns MP, Tukey RH. PMID: 10024527.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    81. UDP-glucuronosyltransferase activity in human liver and colon. Gastroenterology. 1999 Jan; 116(1):149-60. Strassburg CP, Nguyen N, Manns MP, Tukey RH. PMID: 9869613.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    82. Physiological and pathophysiological regulation of cytochrome P450. Drug Metab Dispos. 1998 Dec; 26(12):1232-40. Morgan ET, Sewer MB, Iber H, Gonzalez FJ, Lee YH, Tukey RH, Okino S, Vu T, Chen YH, Sidhu JS, Omiecinski CJ. PMID: 9860933.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    83. Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Mol Pharmacol. 1998 Oct; 54(4):647-54. Strassburg CP, Nguyen N, Manns MP, Tukey RH. PMID: 9765507.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    84. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem. 1998 Apr 10; 273(15):8719-26. Strassburg CP, Manns MP, Tukey RH. PMID: 9535849.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    85. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. Arch Biochem Biophys. 1997 Dec 15; 348(2):357-64. Bruck M, Li Q, Lamb JG, Tukey RH. PMID: 9463278.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    86. Heterologous expression of human drug-metabolizing enzymes. Drug Metab Dispos. 1997 Nov; 25(11):1234-41. Guengerich FP, Parikh A, Johnson EF, Richardson TH, von Wachenfeldt C, Cosme J, Jung F, Strassburg CP, Manns MP, Tukey RH, Pritchard M, Fournel-Gigleux S, Burchell B. PMID: 9351898.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    87. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. Arch Biochem Biophys. 1997 Aug 15; 344(2):357-64. Bruck M, Li Q, Lamb JG, Tukey RH. PMID: 9264550.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    88. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol. 1997 Aug; 52(2):212-20. Strassburg CP, Oldhafer K, Manns MP, Tukey RH. PMID: 9271343.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    89. Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Cancer Res. 1997 Jul 15; 57(14):2979-85. Strassburg CP, Manns MP, Tukey RH. PMID: 9230212.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    90. Baculovirus-directed expression of rabbit UDP-glucuronosyltransferases in Spodoptera frugiperda cells. Drug Metab Dispos. 1997 Jun; 25(6):745-9. Nguyen N, Tukey RH. PMID: 9193877.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    91. Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metab. 1997 May; 82(5):1353-61. Clemente MG, Obermayer-Straub P, Meloni A, Strassburg CP, Arangino V, Tukey RH, De Virgiliis S, Manns MP. PMID: 9141515.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    92. Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. Carcinogenesis. 1997 Apr; 18(4):851-4. Hammons GJ, Milton D, Stepps K, Guengerich FP, Tukey RH, Kadlubar FF. PMID: 9111224.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    93. Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13. J Biol Chem. 1997 Feb 07; 272(6):3272-9. Li Q, Lou X, Peyronneau MA, Straub PO, Tukey RH. PMID: 9013565.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    94. Identification of rat and human cytochrome P450 forms involved in the metabolism of the thromboxane A2 receptor antagonist (+)-S-145. Drug Metab Dispos. 1997 Jan; 25(1):75-80. Yamaguchi Y, Kirita S, Baba T, Aoyama J, Touchi A, Tukey RH, Guengerich FP, Matsubara T. PMID: 9010633.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    95. Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Gastroenterology. 1996 Dec; 111(6):1576-86. Strassburg CP, Obermayer-Straub P, Alex B, Durazzo M, Rizzetto M, Tukey RH, Manns MP. PMID: 8942737.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    96. Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor. J Biol Chem. 1996 Oct 18; 271(42):26261-6. Chen YH, Tukey RH. PMID: 8824276.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    97. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol. 1996 Jul; 50(1):10-6. Barwick JL, Quattrochi LC, Mills AS, Potenza C, Tukey RH, Guzelian PS. PMID: 8700101.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    98. Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2. Drug Metab Dispos. 1996 Jun; 24(6):692-4. Ching MS, Bichara N, Blake CL, Ghabrial H, Tukey RH, Smallwood RA. PMID: 8781788.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    99. Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen. Biochem Pharmacol. 1996 Apr 26; 51(8):1003-8. Miners JO, Coulter S, Tukey RH, Veronese ME, Birkett DJ. PMID: 8866821.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    100. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. J Pharmacol Exp Ther. 1996 Jan; 276(1):101-8. Tassaneeyakul W, Birkett DJ, Edwards JW, Veronese ME, Tassaneeyakul W, Tukey RH, Miners JO. PMID: 8558417.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    101. Metabolism of polycyclic aza-aromatic carcinogens catalyzed by four expressed human cytochromes P450. Cancer Res. 1995 Mar 01; 55(5):1052-9. Roberts-Thomson SJ, McManus ME, Tukey RH, Gonzalez FJ, Holder GM. PMID: 7866988.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    102. Molecular analysis of autoantigens in hepatitis D. J Hepatol. 1995; 22(1 Suppl):132-5. Philipp T, Straub P, Durazzo M, Tukey RH, Manns MP. PMID: 7602065.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    103. Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. Carcinogenesis. 1994 Nov; 15(11):2523-9. Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FP. PMID: 7955101.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    104. Direct characterization of the selectivity of furafylline as an inhibitor of human cytochromes P450 1A1 and 1A2. Pharmacogenetics. 1994 Oct; 4(5):281-4. Tassaneeyakul W, Birkett DJ, Veronese ME, McManus ME, Tukey RH, Miners JO. PMID: 7894501.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    105. Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemistry. 1994 Aug 30; 33(34):10513-20. Lamb JG, Straub P, Tukey RH. PMID: 8068691.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    106. Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D. Lancet. 1994 Aug 27; 344(8922):578-81. Philipp T, Durazzo M, Trautwein C, Alex B, Straub P, Lamb JG, Johnson EF, Tukey RH, Manns MP. PMID: 7914961.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    107. Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties. Arch Biochem Biophys. 1994 Aug 01; 312(2):436-46. Guo Z, Gillam EM, Ohmori S, Tukey RH, Guengerich FP. PMID: 8037457.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    108. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol. 1994 May 18; 47(10):1767-76. Tassaneeyakul W, Birkett DJ, McManus ME, Tassaneeyakul W, Veronese ME, Andersson T, Tukey RH, Miners JO. PMID: 8204093.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    109. The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction. J Biol Chem. 1994 Mar 04; 269(9):6949-54. Quattrochi LC, Vu T, Tukey RH. PMID: 8120057.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    110. Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme. Arch Biochem Biophys. 1994 Feb 15; 309(1):168-77. Sandhu P, Guo Z, Baba T, Martin MV, Tukey RH, Guengerich FP. PMID: 8117105.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    111. Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes. Arch Biochem Biophys. 1993 Oct; 306(1):65-9. Pendurthi UR, Okino ST, Tukey RH. PMID: 8215422.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    112. Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13. J Biol Chem. 1993 Jul 15; 268(20):15260-6. Tukey RH, Pendurthi UR, Nguyen NT, Green MD, Tephly TR. PMID: 8325897.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    113. The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen. Biochem Biophys Res Commun. 1993 May 14; 192(3):1373-9. Roberts-Thomson SJ, McManus ME, Tukey RH, Gonzalez FF, Holder GM. PMID: 8507205.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    114. Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. Mol Pharmacol. 1993 Apr; 43(4):504-8. Quattrochi LC, Tukey RH. PMID: 8386305.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    115. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces the nuclear translocation of two XRE binding proteins in mice. Pharmacogenetics. 1993 Apr; 3(2):101-9. Okino ST, Pendurthi UR, Tukey RH. PMID: 8390902.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    116. Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J Pharmacol Exp Ther. 1993 Apr; 265(1):401-7. Tassaneeyakul W, Birkett DJ, Veronese ME, McManus ME, Tukey RH, Quattrochi LC, Gelboin HV, Miners JO. PMID: 8474022.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    117. Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Toxicol Appl Pharmacol. 1993 Feb; 118(2):255-62. Postlind H, Vu TP, Tukey RH, Quattrochi LC. PMID: 8442004.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    118. Caffeine as a probe for human cytochromes P450: validation using cDNA-expression, immunoinhibition and microsomal kinetic and inhibitor techniques. Pharmacogenetics. 1992 Aug; 2(4):173-83. Tassaneeyakul W, Mohamed Z, Birkett DJ, McManus ME, Veronese ME, Tukey RH, Quattrochi LC, Gonzalez FJ, Miners JO. PMID: 1306118.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    119. Characterization of the rabbit CYP1A1 and CYP1A2 genes: developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2. Arch Biochem Biophys. 1992 May 01; 294(2):707-16. Strom DK, Postlind H, Tukey RH. PMID: 1567227.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    120. Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1992 Apr 05; 267(10):6991-8. Okino ST, Pendurthi UR, Tukey RH. PMID: 1313028.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    121. Characterization of a rabbit factor IX cDNA. Thromb Res. 1992 Jan 15; 65(2):177-86. Pendurthi UR, Tukey RH, Rao LV. PMID: 1579894.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    122. High-level expression of functional human cytochrome P450 1A2 in Escherichia coli. FASEB J. 1992 Jan 06; 6(2):759-64. Fisher CW, Caudle DL, Martin-Wixtrom C, Quattrochi LC, Tukey RH, Waterman MR, Estabrook RW. PMID: 1537466.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    123. Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. Hepatology. 1991 Nov; 14(5):848-56. McKinnon RA, Hall PD, Quattrochi LC, Tukey RH, McManus ME. PMID: 1657755.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    124. Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor. Mol Cell Biol. 1991 Sep; 11(9):4314-23. Hapgood J, Cuthill S, Söderkvist P, Wilhelmsson A, Pongratz I, Tukey RH, Johnson EF, Gustafsson JA, Poellinger L. PMID: 1652054.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    125. Quantitation of related gene products by nuclear run-on and northern blot analysis. Methods Enzymol. 1991; 206:284-90. Tukey RH, Okino ST. PMID: 1723783.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    126. Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P450IIC5. J Biol Chem. 1990 Aug 25; 265(24):14662-8. Pendurthi UR, Lamb JG, Nguyen N, Johnson EF, Tukey RH. PMID: 2387874.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    127. Identification of cytochrome P450IA2 as a human autoantigen. Arch Biochem Biophys. 1990 Jul; 280(1):229-32. Manns MP, Griffin KJ, Quattrochi LC, Sacher M, Thaler H, Tukey RH, Johnson EF. PMID: 2353823.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    128. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res. 1990 Jun 01; 50(11):3367-76. McManus ME, Burgess WM, Veronese ME, Huggett A, Quattrochi LC, Tukey RH. PMID: 2334931.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCellsPHPublic Health
    129. Metabolism of food derived mutagens and 2-acetylaminofluorene by purified rabbit and cDNA expressed human cytochromes P450. Prog Clin Biol Res. 1990; 340E:139-47. McManus ME, Burgess WM, Veronese ME, Felton JS, Knize MG, Snyderwine EG, Quattrochi LC, Tukey RH. PMID: 2392457.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    130. Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin. J Biol Chem. 1989 Sep 25; 264(27):16222-8. Potenza CL, Pendurthi UR, Strom DK, Tukey RH, Griffin KJ, Schwab GE, Johnson EF. PMID: 2777787.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    131. Genetic contributions to the variation among rabbits of liver microsomal deoxycorticosterone synthesis. Arch Biochem Biophys. 1989 Sep; 273(2):273-80. Johnson EF, Finlayson M, Hujsak CM, Pendurthi UR, Tukey RH. PMID: 2570549.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    132. The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol Pharmacol. 1989 Jul; 36(1):66-71. Quattrochi LC, Tukey RH. PMID: 2747632.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    133. Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing. J Biol Chem. 1987 Nov 25; 262(33):16072-9. Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH. PMID: 3500169.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    134. Characterization of a second gene product related to rabbit cytochrome P-450 1. J Biol Chem. 1987 Apr 25; 262(12):5918-23. Johnson EF, Barnes HJ, Griffin KJ, Okino S, Tukey RH. PMID: 3032948.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    135. Intraspecies individuality for the metabolism of steroids. Xenobiotica. 1987 Mar; 17(3):275-85. Johnson EF, Finlayson M, Raucy J, Barnes H, Schwab GE, Griffin KJ, Tukey RH. PMID: 3577205.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    136. Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6731-5. Quattrochi LC, Pendurthi UR, Okino ST, Potenza C, Tukey RH. PMID: 3462722.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    137. Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1. J Biol Chem. 1985 Oct 25; 260(24):13347-54. Tukey RH, Okino S, Barnes H, Griffin KJ, Johnson EF. PMID: 3902818.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    138. Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. DNA. 1985 Oct; 4(5):395-400. Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH. PMID: 3000715.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    139. Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5310-4. Okino ST, Quattrochi LC, Barnes HJ, Osanto S, Griffin KJ, Johnson EF, Tukey RH. PMID: 2991917.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    140. Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone. Biochemistry. 1984 Dec 04; 23(25):6003-8. Tukey RH, Nebert DW. PMID: 6395889.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    141. Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. Mol Pharmacol. 1984 Jul; 26(1):117-21. Gonzalez FJ, Tukey RH, Nebert DW. PMID: 6749129.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    142. Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9. Proc Natl Acad Sci U S A. 1984 May; 81(10):3163-6. Tukey RH, Lalley PA, Nebert DW. PMID: 6328503.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    143. Cloning genes that encode inducible forms of P-450. Biochem Soc Trans. 1984 Feb; 12(1):99-101. Nebert DW, Negishi M, Chen YT, Tukey RH. PMID: 6705999.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    144. Differential regulation by triiodothyronine of substrate-specific uridinediphosphoglucuronate glucuronosyl transferases in rat liver. Biochim Biophys Acta. 1983 Nov 22; 761(1):58-65. Chowdhury JR, Chowdhury NR, Moscioni AD, Tukey R, Tephly T, Arias IM. PMID: 6416299.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    145. Structure of the mouse cytochrome P1-450 genomic gene. Eur J Biochem. 1983 Jul 15; 134(1):19-25. Nakamura M, Negishi M, Altieri M, Chen YT, Ikeda T, Tukey RH, Nebert DW. PMID: 6861759.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    146. Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. Eur J Biochem. 1983 Jul 15; 134(1):13-8. Ikeda T, Altieri M, Chen YT, Nakamura M, Tukey RH, Nebert DW, Negishi M. PMID: 6861755.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    147. Cloning genes that encode drug-metabolizing enzymes: developmental pharmacology and teratology. Prog Clin Biol Res. 1983; 135:61-79. Nebert DW, Chen YT, Negishi M, Tukey RH. PMID: 6320222.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    148. The Ah locus: correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA. Cell. 1982 Nov; 31(1):275-84. Tukey RH, Hannah RR, Negishi M, Nebert DW, Eisen HJ. PMID: 6186383.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    149. Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice. Mol Pharmacol. 1982 Nov; 22(3):779-86. Tukey RH, Negishi M, Nebert DW. PMID: 7155135.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    150. A procedure for the rapid separation and purification of UDP-glucuronosyltransferases from rabbit liver microsomes. Drug Metab Dispos. 1982 Mar-Apr; 10(2):97-101. Tukey RH, Robinson R, Holm B, Falany CN, Tephly TR. PMID: 6124411.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    151. Similarities between mouse and rat-liver microsomal cytochromes P-450 induced by 3-methylcholanthrene. Evidence from catalytic, immunologic, and recombinant DNA studies. Eur J Biochem. 1982 Feb; 122(2):361-8. Chen YT, Lang MA, Jensen NM, Negishi M, Tukey RH, Sidransky E, Guenther TM, Nebert DW. PMID: 7082463.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    152. Structural gene product of the [Ah] complex. Evidence for transcriptional control of cytochrome P1-450 induction by use of a cloned DNA sequence. J Biol Chem. 1981 Jul 10; 256(13):6969-74. Tukey RH, Nebert DW, Negishi M. PMID: 6263927.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    153. Purification of properties of rabbit liver estrone and p-nitrophenol UDP-glucuronyltransferases. Arch Biochem Biophys. 1981 Jul; 209(2):565-78. Tukey RH, Tephly TR. PMID: 6794456.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    154. Estrone and 4-nitrophenol UDPglucuronyltransferases (rabbit liver). Methods Enzymol. 1981; 77:177-88. Tukey RH, Tephly TR. PMID: 6799733.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    155. Phospholipid dependency of purified estrone and p-nitrophenol UDP-glucuronyltransferases. Life Sci. 1980 Dec 22-29; 27(25-26):2471-6. Tukey R, Tephly T. PMID: 6783797.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    156. Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase. Biochem J. 1979 Apr 01; 179(1):59-65. Tukey RH, Billings RE, Autor AP, Tephly TR. PMID: 112996.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    157. Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities. Biochem J. 1978 Jun 01; 171(3):659-63. Tukey RH, Billings RE, Tephly TR. PMID: 96815.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    158. Mechanism of action of novel anti-inflammmatory drugs diflumidone and R-805. Biochem Pharmacol. 1977 Feb 15; 26(4):307-11. Vigdahl RL, Tukey RH. PMID: 403918.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
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