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Robert Tukey

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Phone858-822-0288
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of Iowa
    B.S.University of Minnesota

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Novel regulatory events that control expression of the UGT1A1 gene
    NIH/NIGMS R01GM126074Jan 15, 2018 - Nov 30, 2021
    Role: Principal Investigator
    Neonatal hyperbilirubinemia in a humanized UGT1 animal model
    NIH/NIGMS R01GM100481Mar 15, 2012 - Dec 31, 2015
    Role: Principal Investigator
    Co-repressors SMRT and NCoR1 regulate UGT1A1 gene expression
    NIH/NIGMS R01GM086713Sep 1, 2009 - Apr 30, 2018
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Principal Investigator
    GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    NIH/NCI R01CA079834Dec 17, 1998 - Nov 30, 2002
    Role: Principal Investigator
    Regulated Properties of the Human UGT1A1 Gene.
    NIH/NIGMS R01GM049135Apr 1, 1994 - Nov 30, 2007
    Role: Principal Investigator
    CYTOCHROME P450 GENES AND THEIR REGULATION
    NIH/NIGMS R01GM036590Apr 1, 1986 - Jun 30, 2001
    Role: Principal Investigator
    REGULATION OF THE AH RECEPTOR BY PHORBOL ESTERS
    NIH/NCI R01CA037139Apr 1, 1984 - Jun 30, 1996
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen S, Tukey RH. Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos. 2018 11; 46(11):1745-1755. PMID: 30093417.
      View in: PubMed
    2. Fujiwara R, Yoda E, Tukey RH. Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet. 2018 Feb; 33(1):9-16. PMID: 29079228.
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    3. Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. Severe Neonatal Hyperbilirubinemia in Crigler-Najjar Syndrome Model Mice Can Be Reversed With Zinc Protoporphyrin. Hepatol Commun. 2017 Oct; 1(8):792-802. PMID: 29399656.
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    4. Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017 07; 45(7):748-754. PMID: 28468837.
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    5. Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 2017 04 19; 7:46489. PMID: 28422158.
      View in: PubMed
    6. Yueh MF, Chen S, Nguyen N, Tukey RH. Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia. Mol Pharmacol. 2017 May; 91(5):545-553. PMID: 28283555.
      View in: PubMed
    7. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. PMID: 28167773.
      View in: PubMed
    8. Hirashima R, Itoh T, Tukey RH, Fujiwara R. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 07; 37(7):863-872. PMID: 28138970.
      View in: PubMed
    9. Hinds TD, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARa. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E244-E252. PMID: 28096081.
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    10. Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 2016 09; 90(3):265-74. PMID: 27413119.
      View in: PubMed
    11. Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. Cadmium and arsenic override NF-?B developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46. PMID: 27060662.
      View in: PubMed
    12. Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. Stage-specific regulation of the WNT/ß-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 06; 64(6):1315-26. PMID: 26921690.
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    13. Mitsugi R, Sumida K, Fujie Y, Tukey RH, Itoh T, Fujiwara R. Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biol Pharm Bull. 2016; 39(10):1604-1610. PMID: 27725437.
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    14. Yueh MF, Tukey RH. Triclosan: A Widespread Environmental Toxicant with Many Biological Effects. Annu Rev Pharmacol Toxicol. 2016; 56:251-72. PMID: 26738475.
      View in: PubMed
    15. Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia. Mol Pharmacol. 2016 Jan; 89(1):84-93. PMID: 26480925.
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    16. Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):63-76.e5. PMID: 26807433.
      View in: PubMed
    17. Fujiwara R, Maruo Y, Chen S, Tukey RH. Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015 Nov 15; 289(1):124-32. PMID: 26342858.
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    18. Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH. The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health. Environ Health Perspect. 2015 Oct; 123(10):909-18. PMID: 25978799.
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    19. Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos. 2015 Jul; 43(7):1071-6. PMID: 25953521.
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    20. Sakamoto M, Itoh T, Tukey RH, Fujiwara R. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet. 2015 Aug; 30(4):269-75. PMID: 26210671.
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    21. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. PMID: 25404284.
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    22. Aoshima N, Fujie Y, Itoh T, Tukey RH, Fujiwara R. Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia. Sci Rep. 2014 Sep 11; 4:6343. PMID: 25209391.
      View in: PubMed
    23. Kutsuno Y, Itoh T, Tukey RH, Fujiwara R. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos. 2014 Jul; 42(7):1146-52. PMID: 24764149.
      View in: PubMed
    24. Maruo Y, Morioka Y, Fujito H, Nakahara S, Yanagi T, Matsui K, Mori A, Sato H, Tukey RH, Takeuchi Y. Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice. J Pediatr. 2014 Jul; 165(1):36-41.e1. PMID: 24650397.
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    25. Yueh MF, Chen S, Nguyen N, Tukey RH. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014 Feb 21; 289(8):4699-709. PMID: 24403077.
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    26. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. PMID: 24191041.
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    27. Shibuya A, Itoh T, Tukey RH, Fujiwara R. Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia. Sci Rep. 2013 Oct 09; 3:2903. PMID: 24104695.
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    28. Kutsuno Y, Sumida K, Itoh T, Tukey RH, Fujiwara R. Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes. Pharmacol Res Perspect. 2013 Oct; 1(1):e00002. PMID: 25505556.
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    29. Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol Pharmacol. 2013 Nov; 84(5):679-86. PMID: 23950218.
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    30. Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS. Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys. 2013 Jul 15; 535(2):143-9. PMID: 23562620.
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    31. Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets. 2012 Nov; 16(11):1075-83. PMID: 22913318.
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    32. Yueh MF, Li T, Evans RM, Hammock B, Tukey RH. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 2012; 7(6):e37705. PMID: 22761658.
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    33. Chen S, Yueh MF, Evans RM, Tukey RH. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67. PMID: 22371261.
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    34. Fujiwara R, Chen S, Karin M, Tukey RH. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-?B leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. PMID: 21983082.
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    35. Vogel A, Ockenga J, Tukey RH, Manns MP, Strassburg CP. Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited. Gastroenterology. 2011 May; 140(5):1692-3. PMID: 21440586.
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    36. Yueh MF, Mellon PL, Tukey RH. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011 Jun; 79(6):1053-60. PMID: 21415305.
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    37. Fujiwara R, Nguyen N, Chen S, Tukey RH. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5024-9. PMID: 20194756.
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    38. Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos. 2010 May; 38(5):879-86. PMID: 20124398.
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    39. Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov; 39(11):826-35. PMID: 19845433.
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    40. Savas U, Machemer DE, Hsu MH, Gaynor P, Lasker JM, Tukey RH, Johnson EF. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem. 2009 Jun 12; 284(24):16541-52. PMID: 19366684.
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    41. Chouinard S, Yueh MF, Tukey RH, Giton F, Fiet J, Pelletier G, Barbier O, Bélanger A. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. J Steroid Biochem Mol Biol. 2008 Apr; 109(3-5):247-53. PMID: 18467088.
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    42. Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11. PMID: 18180294.
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    43. Bonzo JA, Bélanger A, Tukey RH. The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology. 2007 Feb; 45(2):349-60. PMID: 17256720.
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    44. Yueh MF, Tukey RH. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem. 2007 Mar 23; 282(12):8749-58. PMID: 17259171.
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    45. Pezzoli K, Tukey R, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman M. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect. 2007 Apr; 115(4):564-71. PMID: 17450225.
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    46. Operaña TN, Tukey RH. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007 Feb 16; 282(7):4821-9. PMID: 17179145.
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    47. Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar; 35(3):419-27. PMID: 17151188.
      View in: PubMed
    48. Operaña TN, Nguyen N, Chen S, Beaton D, Tukey RH. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci. 2007 Jan; 95(1):98-107. PMID: 17065433.
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    49. Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Bélanger J, Kaeding J, Staels B, Caron P, Tukey RH, Barbier O. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology. 2006 Aug; 44(2):368-78. PMID: 16871576.
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    50. Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11; 280(45):37547-57. PMID: 16155002.
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    51. Machemer DE, Tukey RH. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci. 2005 Sep; 87(1):27-37. PMID: 15947024.
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    52. Bonzo JA, Chen S, Galijatovic A, Tukey RH. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol. 2005 Apr; 67(4):1247-56. PMID: 15630080.
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    53. Yueh MF, Bonzo JA, Tukey RH. The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1. Methods Enzymol. 2005; 400:75-91. PMID: 16399344.
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    54. Chen S, Operaña T, Bonzo J, Nguyen N, Tukey RH. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem. 2005 Feb 11; 280(6):4350-9. PMID: 15572374.
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    55. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. PMID: 15037607.
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    56. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4150-5. PMID: 12644700.
      View in: PubMed
    57. Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. PMID: 12637498.
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    58. Yueh MF, Huang YH, Hiller A, Chen S, Nguyen N, Tukey RH. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 2003 Apr 25; 278(17):15001-6. PMID: 12566446.
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    59. Tukey RH, Strassburg CP, Mackenzie PI. Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity. Mol Pharmacol. 2002 Sep; 62(3):446-50. PMID: 12181419.
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    60. Vogel A, Ockenga J, Ehmer U, Barut A, Kramer FJ, Tukey RH, Manns MP, Strassburg CP. Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer. Z Gastroenterol. 2002 Jul; 40(7):497-502. PMID: 12122597.
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    61. Strassburg CP, Vogel A, Kneip S, Tukey RH, Manns MP. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut. 2002 Jun; 50(6):851-6. PMID: 12010889.
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    62. Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenetics. 2002 Jun; 12(4):287-97. PMID: 12042666.
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    63. Strassburg A, Strassburg CP, Manns MP, Tukey RH. Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue. Mol Pharmacol. 2002 Feb; 61(2):320-5. PMID: 11809856.
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    64. Strassburg CP, Strassburg A, Kneip S, Barut A, Tukey RH, Rodeck B, Manns MP. Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut. 2002 Feb; 50(2):259-65. PMID: 11788570.
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    65. Vogel A, Kneip S, Barut A, Ehmer U, Tukey RH, Manns MP, Strassburg CP. Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. Gastroenterology. 2001 Nov; 121(5):1136-44. PMID: 11677206.
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    66. Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis. 2001 Jun; 22(6):943-50. PMID: 11375903.
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    67. Strassburg CP, Barut A, Obermayer-Straub P, Li Q, Nguyen N, Tukey RH, Manns MP. Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7. J Hepatol. 2001 Jun; 34(6):865-72. PMID: 11451170.
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    68. Shipkova M, Strassburg CP, Braun F, Streit F, Gröne HJ, Armstrong VW, Tukey RH, Oellerich M, Wieland E. Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes. Br J Pharmacol. 2001 Mar; 132(5):1027-34. PMID: 11226133.
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    69. Tukey RH, Strassburg CP. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol. 2001 Mar; 59(3):405-14. PMID: 11179432.
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    70. Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem. 2000 Nov 17; 275(46):36164-71. PMID: 10748067.
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    71. Li Q, Lamb G, Tukey RH. Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene. Mol Pharmacol. 2000 Jul; 58(1):89-97. PMID: 10860930.
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    72. Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000; 40:581-616. PMID: 10836148.
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    73. Nowell SA, Massengill JS, Williams S, Radominska-Pandya A, Tephly TR, Cheng Z, Strassburg CP, Tukey RH, MacLeod SL, Lang NP, Kadlubar FF. Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. Carcinogenesis. 1999 Jun; 20(6):1107-14. PMID: 10357796.
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    74. Hiller A, Nguyen N, Strassburg CP, Li Q, Jainta H, Pechstein B, Ruus P, Engel J, Tukey RH, Kronbach T. Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May; 27(5):605-12. PMID: 10220490.
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    75. Strassburg CP, Strassburg A, Nguyen N, Li Q, Manns MP, Tukey RH. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Biochem J. 1999 Mar 01; 338 ( Pt 2):489-98. PMID: 10024527.
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    76. Strassburg CP, Nguyen N, Manns MP, Tukey RH. UDP-glucuronosyltransferase activity in human liver and colon. Gastroenterology. 1999 Jan; 116(1):149-60. PMID: 9869613.
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    77. Morgan ET, Sewer MB, Iber H, Gonzalez FJ, Lee YH, Tukey RH, Okino S, Vu T, Chen YH, Sidhu JS, Omiecinski CJ. Physiological and pathophysiological regulation of cytochrome P450. Drug Metab Dispos. 1998 Dec; 26(12):1232-40. PMID: 9860933.
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    78. Strassburg CP, Nguyen N, Manns MP, Tukey RH. Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Mol Pharmacol. 1998 Oct; 54(4):647-54. PMID: 9765507.
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    79. Strassburg CP, Manns MP, Tukey RH. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem. 1998 Apr 10; 273(15):8719-26. PMID: 9535849.
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    80. Bruck M, Li Q, Lamb JG, Tukey RH. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. Arch Biochem Biophys. 1997 Dec 15; 348(2):357-64. PMID: 9463278.
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    81. Guengerich FP, Parikh A, Johnson EF, Richardson TH, von Wachenfeldt C, Cosme J, Jung F, Strassburg CP, Manns MP, Tukey RH, Pritchard M, Fournel-Gigleux S, Burchell B. Heterologous expression of human drug-metabolizing enzymes. Drug Metab Dispos. 1997 Nov; 25(11):1234-41. PMID: 9351898.
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    82. Bruck M, Li Q, Lamb JG, Tukey RH. Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. Arch Biochem Biophys. 1997 Aug 15; 344(2):357-64. PMID: 9264550.
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    83. Strassburg CP, Oldhafer K, Manns MP, Tukey RH. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol. 1997 Aug; 52(2):212-20. PMID: 9271343.
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    84. Strassburg CP, Manns MP, Tukey RH. Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Cancer Res. 1997 Jul 15; 57(14):2979-85. PMID: 9230212.
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    85. Nguyen N, Tukey RH. Baculovirus-directed expression of rabbit UDP-glucuronosyltransferases in Spodoptera frugiperda cells. Drug Metab Dispos. 1997 Jun; 25(6):745-9. PMID: 9193877.
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    86. Clemente MG, Obermayer-Straub P, Meloni A, Strassburg CP, Arangino V, Tukey RH, De Virgiliis S, Manns MP. Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metab. 1997 May; 82(5):1353-61. PMID: 9141515.
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    87. Hammons GJ, Milton D, Stepps K, Guengerich FP, Tukey RH, Kadlubar FF. Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. Carcinogenesis. 1997 Apr; 18(4):851-4. PMID: 9111224.
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    88. Li Q, Lou X, Peyronneau MA, Straub PO, Tukey RH. Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13. J Biol Chem. 1997 Feb 07; 272(6):3272-9. PMID: 9013565.
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    89. Yamaguchi Y, Kirita S, Baba T, Aoyama J, Touchi A, Tukey RH, Guengerich FP, Matsubara T. Identification of rat and human cytochrome P450 forms involved in the metabolism of the thromboxane A2 receptor antagonist (+)-S-145. Drug Metab Dispos. 1997 Jan; 25(1):75-80. PMID: 9010633.
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    90. Strassburg CP, Obermayer-Straub P, Alex B, Durazzo M, Rizzetto M, Tukey RH, Manns MP. Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Gastroenterology. 1996 Dec; 111(6):1576-86. PMID: 8942737.
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    91. Chen YH, Tukey RH. Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor. J Biol Chem. 1996 Oct 18; 271(42):26261-6. PMID: 8824276.
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    92. Barwick JL, Quattrochi LC, Mills AS, Potenza C, Tukey RH, Guzelian PS. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol. 1996 Jul; 50(1):10-6. PMID: 8700101.
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    93. Ching MS, Bichara N, Blake CL, Ghabrial H, Tukey RH, Smallwood RA. Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2. Drug Metab Dispos. 1996 Jun; 24(6):692-4. PMID: 8781788.
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    94. Miners JO, Coulter S, Tukey RH, Veronese ME, Birkett DJ. Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen. Biochem Pharmacol. 1996 Apr 26; 51(8):1003-8. PMID: 8866821.
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    95. Tassaneeyakul W, Birkett DJ, Edwards JW, Veronese ME, Tassaneeyakul W, Tukey RH, Miners JO. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. J Pharmacol Exp Ther. 1996 Jan; 276(1):101-8. PMID: 8558417.
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    96. Roberts-Thomson SJ, McManus ME, Tukey RH, Gonzalez FJ, Holder GM. Metabolism of polycyclic aza-aromatic carcinogens catalyzed by four expressed human cytochromes P450. Cancer Res. 1995 Mar 01; 55(5):1052-9. PMID: 7866988.
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    97. Philipp T, Straub P, Durazzo M, Tukey RH, Manns MP. Molecular analysis of autoantigens in hepatitis D. J Hepatol. 1995; 22(1 Suppl):132-5. PMID: 7602065.
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    98. Shimada T, Gillam EM, Sandhu P, Guo Z, Tukey RH, Guengerich FP. Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. Carcinogenesis. 1994 Nov; 15(11):2523-9. PMID: 7955101.
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    99. Tassaneeyakul W, Birkett DJ, Veronese ME, McManus ME, Tukey RH, Miners JO. Direct characterization of the selectivity of furafylline as an inhibitor of human cytochromes P450 1A1 and 1A2. Pharmacogenetics. 1994 Oct; 4(5):281-4. PMID: 7894501.
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    100. Lamb JG, Straub P, Tukey RH. Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemistry. 1994 Aug 30; 33(34):10513-20. PMID: 8068691.
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    101. Philipp T, Durazzo M, Trautwein C, Alex B, Straub P, Lamb JG, Johnson EF, Tukey RH, Manns MP. Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D. Lancet. 1994 Aug 27; 344(8922):578-81. PMID: 7914961.
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    102. Guo Z, Gillam EM, Ohmori S, Tukey RH, Guengerich FP. Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties. Arch Biochem Biophys. 1994 Aug 01; 312(2):436-46. PMID: 8037457.
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    103. Tassaneeyakul W, Birkett DJ, McManus ME, Tassaneeyakul W, Veronese ME, Andersson T, Tukey RH, Miners JO. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol. 1994 May 18; 47(10):1767-76. PMID: 8204093.
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    104. Quattrochi LC, Vu T, Tukey RH. The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction. J Biol Chem. 1994 Mar 04; 269(9):6949-54. PMID: 8120057.
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    105. Sandhu P, Guo Z, Baba T, Martin MV, Tukey RH, Guengerich FP. Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme. Arch Biochem Biophys. 1994 Feb 15; 309(1):168-77. PMID: 8117105.
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    106. Pendurthi UR, Okino ST, Tukey RH. Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes. Arch Biochem Biophys. 1993 Oct; 306(1):65-9. PMID: 8215422.
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    107. Tukey RH, Pendurthi UR, Nguyen NT, Green MD, Tephly TR. Cloning and characterization of rabbit liver UDP-glucuronosyltransferase cDNAs. Developmental and inducible expression of 4-hydroxybiphenyl UGT2B13. J Biol Chem. 1993 Jul 15; 268(20):15260-6. PMID: 8325897.
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    108. Roberts-Thomson SJ, McManus ME, Tukey RH, Gonzalez FF, Holder GM. The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen. Biochem Biophys Res Commun. 1993 May 14; 192(3):1373-9. PMID: 8507205.
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    109. Quattrochi LC, Tukey RH. Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. Mol Pharmacol. 1993 Apr; 43(4):504-8. PMID: 8386305.
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    110. Okino ST, Pendurthi UR, Tukey RH. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces the nuclear translocation of two XRE binding proteins in mice. Pharmacogenetics. 1993 Apr; 3(2):101-9. PMID: 8390902.
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    111. Tassaneeyakul W, Birkett DJ, Veronese ME, McManus ME, Tukey RH, Quattrochi LC, Gelboin HV, Miners JO. Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J Pharmacol Exp Ther. 1993 Apr; 265(1):401-7. PMID: 8474022.
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    112. Postlind H, Vu TP, Tukey RH, Quattrochi LC. Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Toxicol Appl Pharmacol. 1993 Feb; 118(2):255-62. PMID: 8442004.
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    113. Tassaneeyakul W, Mohamed Z, Birkett DJ, McManus ME, Veronese ME, Tukey RH, Quattrochi LC, Gonzalez FJ, Miners JO. Caffeine as a probe for human cytochromes P450: validation using cDNA-expression, immunoinhibition and microsomal kinetic and inhibitor techniques. Pharmacogenetics. 1992 Aug; 2(4):173-83. PMID: 1306118.
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    114. Strom DK, Postlind H, Tukey RH. Characterization of the rabbit CYP1A1 and CYP1A2 genes: developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2. Arch Biochem Biophys. 1992 May 01; 294(2):707-16. PMID: 1567227.
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    115. Okino ST, Pendurthi UR, Tukey RH. Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1992 Apr 05; 267(10):6991-8. PMID: 1313028.
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    116. Pendurthi UR, Tukey RH, Rao LV. Characterization of a rabbit factor IX cDNA. Thromb Res. 1992 Jan 15; 65(2):177-86. PMID: 1579894.
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    117. Fisher CW, Caudle DL, Martin-Wixtrom C, Quattrochi LC, Tukey RH, Waterman MR, Estabrook RW. High-level expression of functional human cytochrome P450 1A2 in Escherichia coli. FASEB J. 1992 Jan 06; 6(2):759-64. PMID: 1537466.
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    118. McKinnon RA, Hall PD, Quattrochi LC, Tukey RH, McManus ME. Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. Hepatology. 1991 Nov; 14(5):848-56. PMID: 1657755.
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    119. Hapgood J, Cuthill S, Söderkvist P, Wilhelmsson A, Pongratz I, Tukey RH, Johnson EF, Gustafsson JA, Poellinger L. Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor. Mol Cell Biol. 1991 Sep; 11(9):4314-23. PMID: 1652054.
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    120. Tukey RH, Okino ST. Quantitation of related gene products by nuclear run-on and northern blot analysis. Methods Enzymol. 1991; 206:284-90. PMID: 1723783.
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    121. Pendurthi UR, Lamb JG, Nguyen N, Johnson EF, Tukey RH. Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P450IIC5. J Biol Chem. 1990 Aug 25; 265(24):14662-8. PMID: 2387874.
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    122. Manns MP, Griffin KJ, Quattrochi LC, Sacher M, Thaler H, Tukey RH, Johnson EF. Identification of cytochrome P450IA2 as a human autoantigen. Arch Biochem Biophys. 1990 Jul; 280(1):229-32. PMID: 2353823.
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    123. McManus ME, Burgess WM, Veronese ME, Huggett A, Quattrochi LC, Tukey RH. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res. 1990 Jun 01; 50(11):3367-76. PMID: 2334931.
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    124. McManus ME, Burgess WM, Veronese ME, Felton JS, Knize MG, Snyderwine EG, Quattrochi LC, Tukey RH. Metabolism of food derived mutagens and 2-acetylaminofluorene by purified rabbit and cDNA expressed human cytochromes P450. Prog Clin Biol Res. 1990; 340E:139-47. PMID: 2392457.
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    125. Potenza CL, Pendurthi UR, Strom DK, Tukey RH, Griffin KJ, Schwab GE, Johnson EF. Regulation of the rabbit cytochrome P-450 3c gene. Age-dependent expression and transcriptional activation by rifampicin. J Biol Chem. 1989 Sep 25; 264(27):16222-8. PMID: 2777787.
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    126. Johnson EF, Finlayson M, Hujsak CM, Pendurthi UR, Tukey RH. Genetic contributions to the variation among rabbits of liver microsomal deoxycorticosterone synthesis. Arch Biochem Biophys. 1989 Sep; 273(2):273-80. PMID: 2570549.
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    127. Quattrochi LC, Tukey RH. The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol Pharmacol. 1989 Jul; 36(1):66-71. PMID: 2747632.
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    128. Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH. Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing. J Biol Chem. 1987 Nov 25; 262(33):16072-9. PMID: 3500169.
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    129. Johnson EF, Barnes HJ, Griffin KJ, Okino S, Tukey RH. Characterization of a second gene product related to rabbit cytochrome P-450 1. J Biol Chem. 1987 Apr 25; 262(12):5918-23. PMID: 3032948.
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    130. Johnson EF, Finlayson M, Raucy J, Barnes H, Schwab GE, Griffin KJ, Tukey RH. Intraspecies individuality for the metabolism of steroids. Xenobiotica. 1987 Mar; 17(3):275-85. PMID: 3577205.
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    131. Quattrochi LC, Pendurthi UR, Okino ST, Potenza C, Tukey RH. Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6731-5. PMID: 3462722.
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    132. Tukey RH, Okino S, Barnes H, Griffin KJ, Johnson EF. Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1. J Biol Chem. 1985 Oct 25; 260(24):13347-54. PMID: 3902818.
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    133. Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH. Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. DNA. 1985 Oct; 4(5):395-400. PMID: 3000715.
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    134. Okino ST, Quattrochi LC, Barnes HJ, Osanto S, Griffin KJ, Johnson EF, Tukey RH. Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5310-4. PMID: 2991917.
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    135. Tukey RH, Nebert DW. Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone. Biochemistry. 1984 Dec 04; 23(25):6003-8. PMID: 6395889.
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    136. Gonzalez FJ, Tukey RH, Nebert DW. Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. Mol Pharmacol. 1984 Jul; 26(1):117-21. PMID: 6749129.
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    137. Tukey RH, Lalley PA, Nebert DW. Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9. Proc Natl Acad Sci U S A. 1984 May; 81(10):3163-6. PMID: 6328503.
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    138. Nebert DW, Negishi M, Chen YT, Tukey RH. Cloning genes that encode inducible forms of P-450. Biochem Soc Trans. 1984 Feb; 12(1):99-101. PMID: 6705999.
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    139. Chowdhury JR, Chowdhury NR, Moscioni AD, Tukey R, Tephly T, Arias IM. Differential regulation by triiodothyronine of substrate-specific uridinediphosphoglucuronate glucuronosyl transferases in rat liver. Biochim Biophys Acta. 1983 Nov 22; 761(1):58-65. PMID: 6416299.
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    140. Nakamura M, Negishi M, Altieri M, Chen YT, Ikeda T, Tukey RH, Nebert DW. Structure of the mouse cytochrome P1-450 genomic gene. Eur J Biochem. 1983 Jul 15; 134(1):19-25. PMID: 6861759.
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    141. Ikeda T, Altieri M, Chen YT, Nakamura M, Tukey RH, Nebert DW, Negishi M. Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. Eur J Biochem. 1983 Jul 15; 134(1):13-8. PMID: 6861755.
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    142. Nebert DW, Chen YT, Negishi M, Tukey RH. Cloning genes that encode drug-metabolizing enzymes: developmental pharmacology and teratology. Prog Clin Biol Res. 1983; 135:61-79. PMID: 6320222.
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    143. Tukey RH, Hannah RR, Negishi M, Nebert DW, Eisen HJ. The Ah locus: correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA. Cell. 1982 Nov; 31(1):275-84. PMID: 6186383.
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    144. Tukey RH, Negishi M, Nebert DW. Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice. Mol Pharmacol. 1982 Nov; 22(3):779-86. PMID: 7155135.
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    145. Tukey RH, Robinson R, Holm B, Falany CN, Tephly TR. A procedure for the rapid separation and purification of UDP-glucuronosyltransferases from rabbit liver microsomes. Drug Metab Dispos. 1982 Mar-Apr; 10(2):97-101. PMID: 6124411.
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    146. Chen YT, Lang MA, Jensen NM, Negishi M, Tukey RH, Sidransky E, Guenther TM, Nebert DW. Similarities between mouse and rat-liver microsomal cytochromes P-450 induced by 3-methylcholanthrene. Evidence from catalytic, immunologic, and recombinant DNA studies. Eur J Biochem. 1982 Feb; 122(2):361-8. PMID: 7082463.
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    147. Tukey RH, Nebert DW, Negishi M. Structural gene product of the [Ah] complex. Evidence for transcriptional control of cytochrome P1-450 induction by use of a cloned DNA sequence. J Biol Chem. 1981 Jul 10; 256(13):6969-74. PMID: 6263927.
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    148. Tukey RH, Tephly TR. Purification of properties of rabbit liver estrone and p-nitrophenol UDP-glucuronyltransferases. Arch Biochem Biophys. 1981 Jul; 209(2):565-78. PMID: 6794456.
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    149. Tukey RH, Tephly TR. Estrone and 4-nitrophenol UDPglucuronyltransferases (rabbit liver). Methods Enzymol. 1981; 77:177-88. PMID: 6799733.
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    150. Tukey R, Tephly T. Phospholipid dependency of purified estrone and p-nitrophenol UDP-glucuronyltransferases. Life Sci. 1980 Dec 22-29; 27(25-26):2471-6. PMID: 6783797.
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    151. Tukey RH, Billings RE, Autor AP, Tephly TR. Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase. Biochem J. 1979 Apr 01; 179(1):59-65. PMID: 112996.
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    152. Tukey RH, Billings RE, Tephly TR. Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities. Biochem J. 1978 Jun 01; 171(3):659-63. PMID: 96815.
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    153. Vigdahl RL, Tukey RH. Mechanism of action of novel anti-inflammmatory drugs diflumidone and R-805. Biochem Pharmacol. 1977 Feb 15; 26(4):307-11. PMID: 403918.
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