Robert Tukey

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of Iowa
    B.S.University of Minnesota

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Lifelong Triclosan Exposure and Fatty Liver Disease
    NIH R21ES031849Jun 16, 2020 - May 31, 2022
    Role: Principal Investigator
    Novel regulatory events that control expression of the UGT1A1 gene
    NIH R01GM126074Jan 15, 2018 - Nov 30, 2021
    Role: Principal Investigator
    Neonatal hyperbilirubinemia in a humanized UGT1 animal model
    NIH R01GM100481Mar 15, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Co-repressors SMRT and NCoR1 regulate UGT1A1 gene expression
    NIH R01GM086713Sep 1, 2009 - Apr 30, 2019
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Principal Investigator
    GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    NIH R01CA079834Dec 17, 1998 - Nov 30, 2002
    Role: Principal Investigator
    Regulated Properties of the Human UGT1A1 Gene.
    NIH R01GM049135Apr 1, 1994 - Nov 30, 2007
    Role: Principal Investigator
    CYTOCHROME P450 GENES AND THEIR REGULATION
    NIH R01GM036590Apr 1, 1986 - Jun 30, 2001
    Role: Principal Investigator
    REGULATION OF THE AH RECEPTOR BY PHORBOL ESTERS
    NIH R01CA037139Apr 1, 1984 - Jun 30, 1996
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Perceived COVID-19 risk and testing experiences in the San Ysidro U.S./Mexico border region. Transl Behav Med. 2023 Jul 01; 13(7):432-441. Salgin L, Ayers LO, Burola ML, Engler AM, Osuna A, Gay L, Cain K, Stadnick N, Rabin B, Zaslavsky I, Laurent LC, Tukey R, Seifert M. PMID: 36999822; PMCID: PMC10314726.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Using ethnographic approaches to document, evaluate, and facilitate virtual community-engaged implementation research. BMC Public Health. 2023 02 28; 23(1):409. Rabin BA, Cain KL, Salgin L, Watson PL, Oswald W, Kaiser BN, Ayers L, Yi C, Alegre A, Ni J, Reyes A, Yu KE, Broyles SL, Tukey R, Laurent LC, Stadnick NA. PMID: 36855118; PMCID: PMC9974043.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem. 2023 03; 299(3):102955. Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JYA, Chang M, Benner CW, Tukey RH, Chen S. PMID: 36720308; PMCID: PMC9996368.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 07 27; 13(1):4346. Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. Engaging Underserved Communities in COVID-19 Health Equity Implementation Research: An Analysis of Community Engagement Resource Needs and Costs. Front Health Serv. 2022; 2. Stadnick NA, Cain KL, Watson P, Oswald W, Ibarra M, Lagoc R, Pezzoli K, Laurent LC, Tukey R, Rabin AB. PMID: 36258685; PMCID: PMC9574473.
      View in: PubMed   Mentions: 3  
    6. Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model. Drug Metab Dispos. 2022 01; 50(1):33-42. Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH. PMID: 34697081; PMCID: PMC8969198.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. Sci Rep. 2021 05 27; 11(1):11107. van der Schoor LWE, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valášková P, Jašprová J, Struik D, Bloks VW, Chen S, Schreuder AB, Vítek L, Tukey RH, Jonker JW. PMID: 34045606; PMCID: PMC8160219.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31259-31266. Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. PMID: 33229553; PMCID: PMC7733785.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    9. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos. 2021 01; 49(1):12-19. Weber AA, Mennillo E, Yang X, van der Schoor LWE, Jonker JW, Chen S, Tukey RH. PMID: 33154041; PMCID: PMC7745083.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    10. Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice. Drug Metab Dispos. 2020 04; 48(4):255-263. Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. PMID: 31980500; PMCID: PMC7065491.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in hUGT1 Mice. Drug Metab Dispos. 2020 01; 48(1):25-30. Paszek M, Tukey RH. PMID: 31704714; PMCID: PMC6904881.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    12. Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos. 2018 11; 46(11):1745-1755. Chen S, Tukey RH. PMID: 30093417; PMCID: PMC6199628.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    13. Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet. 2018 Feb; 33(1):9-16. Fujiwara R, Yoda E, Tukey RH. PMID: 29079228; PMCID: PMC5809266.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    14. Severe Neonatal Hyperbilirubinemia in Crigler-Najjar Syndrome Model Mice Can Be Reversed With Zinc Protoporphyrin. Hepatol Commun. 2017 Oct; 1(8):792-802. Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. PMID: 29399656; PMCID: PMC5678921.
      View in: PubMed   Mentions: 4     Fields:    
    15. Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017 07; 45(7):748-754. Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. PMID: 28468837; PMCID: PMC5478905.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    16. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 2017 04 19; 7:46489. Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH. PMID: 28422158; PMCID: PMC5395973.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    17. Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia. Mol Pharmacol. 2017 May; 91(5):545-553. Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 28283555; PMCID: PMC5416747.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    18. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773; PMCID: PMC5338369.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    19. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 07; 37(7):863-872. Hirashima R, Itoh T, Tukey RH, Fujiwara R. PMID: 28138970; PMCID: PMC5500258.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E244-E252. Hinds TD, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. PMID: 28096081; PMCID: PMC5406988.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    21. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 2016 09; 90(3):265-74. Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R. PMID: 27413119; PMCID: PMC4998668.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    22. Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46. Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. PMID: 27060662; PMCID: PMC5010383.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 06; 64(6):1315-26. Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. PMID: 26921690; PMCID: PMC5010388.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    24. Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biol Pharm Bull. 2016; 39(10):1604-1610. Mitsugi R, Sumida K, Fujie Y, Tukey RH, Itoh T, Fujiwara R. PMID: 27725437; PMCID: PMC5673480.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Triclosan: A Widespread Environmental Toxicant with Many Biological Effects. Annu Rev Pharmacol Toxicol. 2016; 56:251-72. Yueh MF, Tukey RH. PMID: 26738475; PMCID: PMC4774862.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    26. Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia. Mol Pharmacol. 2016 Jan; 89(1):84-93. Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. PMID: 26480925; PMCID: PMC4702100.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):63-76.e5. Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. PMID: 26807433; PMCID: PMC4721636.
      View in: PubMed   Mentions: 4     Fields:    
    28. Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015 Nov 15; 289(1):124-32. Fujiwara R, Maruo Y, Chen S, Tukey RH. PMID: 26342858; PMCID: PMC4708261.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    29. The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health. Environ Health Perspect. 2015 Oct; 123(10):909-18. Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH. PMID: 25978799; PMCID: PMC4590764.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansPHPublic Health
    30. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos. 2015 Jul; 43(7):1071-6. Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. PMID: 25953521; PMCID: PMC4468441.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    31. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet. 2015 Aug; 30(4):269-75. Sakamoto M, Itoh T, Tukey RH, Fujiwara R. PMID: 26210671; PMCID: PMC4752199.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284; PMCID: PMC4260592.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    33. Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia. Sci Rep. 2014 Sep 11; 4:6343. Aoshima N, Fujie Y, Itoh T, Tukey RH, Fujiwara R. PMID: 25209391; PMCID: PMC4160704.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos. 2014 Jul; 42(7):1146-52. Kutsuno Y, Itoh T, Tukey RH, Fujiwara R. PMID: 24764149; PMCID: PMC4053997.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    35. Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice. J Pediatr. 2014 Jul; 165(1):36-41.e1. Maruo Y, Morioka Y, Fujito H, Nakahara S, Yanagi T, Matsui K, Mori A, Sato H, Tukey RH, Takeuchi Y. PMID: 24650397; PMCID: PMC4123958.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    36. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014 Feb 21; 289(8):4699-709. Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 24403077; PMCID: PMC3931032.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    37. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. PMID: 24191041; PMCID: PMC3839688.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    38. Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia. Sci Rep. 2013 Oct 09; 3:2903. Shibuya A, Itoh T, Tukey RH, Fujiwara R. PMID: 24104695; PMCID: PMC3793218.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    39. Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes. Pharmacol Res Perspect. 2013 Oct; 1(1):e00002. Kutsuno Y, Sumida K, Itoh T, Tukey RH, Fujiwara R. PMID: 25505556; PMCID: PMC4184567.
      View in: PubMed   Mentions: 14     Fields:    
    40. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol Pharmacol. 2013 Nov; 84(5):679-86. Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R. PMID: 23950218; PMCID: PMC3807078.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    41. Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys. 2013 Jul 15; 535(2):143-9. Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS. PMID: 23562620; PMCID: PMC4059507.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    42. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets. 2012 Nov; 16(11):1075-83. Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. PMID: 22913318; PMCID: PMC4319648.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    43. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 2012; 7(6):e37705. Yueh MF, Li T, Evans RM, Hammock B, Tukey RH. PMID: 22761658; PMCID: PMC3376094.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    44. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67. Chen S, Yueh MF, Evans RM, Tukey RH. PMID: 22371261; PMCID: PMC3383890.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    45. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082; PMCID: PMC3428231.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    46. Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited. Gastroenterology. 2011 May; 140(5):1692-3. Vogel A, Ockenga J, Tukey RH, Manns MP, Strassburg CP. PMID: 21440586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    47. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. Mol Pharmacol. 2011 Jun; 79(6):1053-60. Yueh MF, Mellon PL, Tukey RH. PMID: 21415305; PMCID: PMC3102552.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    48. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5024-9. Fujiwara R, Nguyen N, Chen S, Tukey RH. PMID: 20194756; PMCID: PMC2841904.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    49. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos. 2010 May; 38(5):879-86. Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. PMID: 20124398; PMCID: PMC2872941.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    50. Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov; 39(11):826-35. Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP. PMID: 19845433; PMCID: PMC2891280.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    51. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem. 2009 Jun 12; 284(24):16541-16552. Savas Ü, Machemer DEW, Hsu MH, Gaynor P, Lasker JM, Tukey RH, Johnson EF. PMID: 19366684; PMCID: PMC2713544.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    52. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. J Steroid Biochem Mol Biol. 2008 Apr; 109(3-5):247-53. Chouinard S, Yueh MF, Tukey RH, Giton F, Fiet J, Pelletier G, Barbier O, Bélanger A. PMID: 18467088.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    53. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11. Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. PMID: 18180294.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    54. The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology. 2007 Feb; 45(2):349-60. Bonzo JA, Bélanger A, Tukey RH. PMID: 17256720.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    55. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem. 2007 Mar 23; 282(12):8749-58. Yueh MF, Tukey RH. PMID: 17259171.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    56. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect. 2007 Apr; 115(4):564-71. Pezzoli K, Tukey R, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman M. PMID: 17450225; PMCID: PMC1852670.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    57. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007 Feb 16; 282(7):4821-4829. Operaña TN, Tukey RH. PMID: 17179145.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    58. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar; 35(3):419-27. Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. PMID: 17151188.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    59. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci. 2007 Jan; 95(1):98-107. Operaña TN, Nguyen N, Chen S, Beaton D, Tukey RH. PMID: 17065433.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    60. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology. 2006 Aug; 44(2):368-78. Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Bélanger J, Kaeding J, Staels B, Caron P, Tukey RH, Barbier O. PMID: 16871576.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    61. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11; 280(45):37547-57. Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. PMID: 16155002.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    62. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci. 2005 Sep; 87(1):27-37. Machemer DE, Tukey RH. PMID: 15947024.
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    138. Characterization of a second gene product related to rabbit cytochrome P-450 1. J Biol Chem. 1987 Apr 25; 262(12):5918-23. Johnson EF, Barnes HJ, Griffin KJ, Okino S, Tukey RH. PMID: 3032948.
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    139. Intraspecies individuality for the metabolism of steroids. Xenobiotica. 1987 Mar; 17(3):275-85. Johnson EF, Finlayson M, Raucy J, Barnes H, Schwab GE, Griffin KJ, Tukey RH. PMID: 3577205.
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    140. Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6731-5. Quattrochi LC, Pendurthi UR, Okino ST, Potenza C, Tukey RH. PMID: 3462722; PMCID: PMC386583.
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    141. Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1. J Biol Chem. 1985 Oct 25; 260(24):13347-54. Tukey RH, Okino S, Barnes H, Griffin KJ, Johnson EF. PMID: 3902818.
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    142. Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. DNA. 1985 Oct; 4(5):395-400. Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH. PMID: 3000715.
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    143. Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5310-4. Okino ST, Quattrochi LC, Barnes HJ, Osanto S, Griffin KJ, Johnson EF, Tukey RH. PMID: 2991917; PMCID: PMC390557.
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    144. Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone. Biochemistry. 1984 Dec 04; 23(25):6003-8. Tukey RH, Nebert DW. PMID: 6395889.
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    145. Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. Mol Pharmacol. 1984 Jul; 26(1):117-21. Gonzalez FJ, Tukey RH, Nebert DW. PMID: 6749129.
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    146. Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9. Proc Natl Acad Sci U S A. 1984 May; 81(10):3163-6. Tukey RH, Lalley PA, Nebert DW. PMID: 6328503; PMCID: PMC345241.
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    147. Cloning genes that encode inducible forms of P-450. Biochem Soc Trans. 1984 Feb; 12(1):99-101. Nebert DW, Negishi M, Chen YT, Tukey RH. PMID: 6705999.
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    148. Differential regulation by triiodothyronine of substrate-specific uridinediphosphoglucuronate glucuronosyl transferases in rat liver. Biochim Biophys Acta. 1983 Nov 22; 761(1):58-65. Chowdhury JR, Chowdhury NR, Moscioni AD, Tukey R, Tephly T, Arias IM. PMID: 6416299.
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    149. Structure of the mouse cytochrome P1-450 genomic gene. Eur J Biochem. 1983 Jul 15; 134(1):19-25. Nakamura M, Negishi M, Altieri M, Chen YT, Ikeda T, Tukey RH, Nebert DW. PMID: 6861759.
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    150. Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. Eur J Biochem. 1983 Jul 15; 134(1):13-8. Ikeda T, Altieri M, Chen YT, Nakamura M, Tukey RH, Nebert DW, Negishi M. PMID: 6861755.
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    151. Cloning genes that encode drug-metabolizing enzymes: developmental pharmacology and teratology. Prog Clin Biol Res. 1983; 135:61-79. Nebert DW, Chen YT, Negishi M, Tukey RH. PMID: 6320222.
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    152. The Ah locus: correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA. Cell. 1982 Nov; 31(1):275-84. Tukey RH, Hannah RR, Negishi M, Nebert DW, Eisen HJ. PMID: 6186383.
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    153. Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice. Mol Pharmacol. 1982 Nov; 22(3):779-86. Tukey RH, Negishi M, Nebert DW. PMID: 7155135.
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    154. A procedure for the rapid separation and purification of UDP-glucuronosyltransferases from rabbit liver microsomes. Drug Metab Dispos. 1982 Mar-Apr; 10(2):97-101. Tukey RH, Robinson R, Holm B, Falany CN, Tephly TR. PMID: 6124411.
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    155. Similarities between mouse and rat-liver microsomal cytochromes P-450 induced by 3-methylcholanthrene. Evidence from catalytic, immunologic, and recombinant DNA studies. Eur J Biochem. 1982 Feb; 122(2):361-8. Chen YT, Lang MA, Jensen NM, Negishi M, Tukey RH, Sidransky E, Guenther TM, Nebert DW. PMID: 7082463.
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    156. Structural gene product of the [Ah] complex. Evidence for transcriptional control of cytochrome P1-450 induction by use of a cloned DNA sequence. J Biol Chem. 1981 Jul 10; 256(13):6969-74. Tukey RH, Nebert DW, Negishi M. PMID: 6263927.
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    157. Purification of properties of rabbit liver estrone and p-nitrophenol UDP-glucuronyltransferases. Arch Biochem Biophys. 1981 Jul; 209(2):565-78. Tukey RH, Tephly TR. PMID: 6794456.
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    158. Estrone and 4-nitrophenol UDPglucuronyltransferases (rabbit liver). Methods Enzymol. 1981; 77:177-88. Tukey RH, Tephly TR. PMID: 6799733.
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    159. Phospholipid dependency of purified estrone and p-nitrophenol UDP-glucuronyltransferases. Life Sci. 1980 Dec 22-29; 27(25-26):2471-6. Tukey R, Tephly T. PMID: 6783797.
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    160. Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase. Biochem J. 1979 Apr 01; 179(1):59-65. Tukey RH, Billings RE, Autor AP, Tephly TR. PMID: 112996; PMCID: PMC1186595.
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    161. Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities. Biochem J. 1978 Jun 01; 171(3):659-63. Tukey RH, Billings RE, Tephly TR. PMID: 96815; PMCID: PMC1184011.
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    162. Mechanism of action of novel anti-inflammmatory drugs diflumidone and R-805. Biochem Pharmacol. 1977 Feb 15; 26(4):307-11. Vigdahl RL, Tukey RH. PMID: 403918.
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