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    Robert Tukey

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0722
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      Ph.D.University of Iowa
      B.S.University of Minnesota

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Novel regulatory events that control expression of the UGT1A1 gene
      NIH/NIGMS R01GM126074Jan 15, 2018 - Nov 30, 2021
      Role: Principal Investigator
      Neonatal hyperbilirubinemia in a humanized UGT1 animal model
      NIH/NIGMS R01GM100481Mar 15, 2012 - Dec 31, 2015
      Role: Principal Investigator
      Co-repressors SMRT and NCoR1 regulate UGT1A1 gene expression
      NIH/NIGMS R01GM086713Sep 1, 2009 - Apr 30, 2018
      Role: Principal Investigator
      NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
      Role: Principal Investigator
      NIH/NCI R01CA079834Dec 17, 1998 - Nov 30, 2002
      Role: Principal Investigator
      Regulated Properties of the Human UGT1A1 Gene.
      NIH/NIGMS R01GM049135Apr 1, 1994 - Nov 30, 2007
      Role: Principal Investigator
      NIH/NIGMS R01GM036590Apr 1, 1986 - Jun 30, 2001
      Role: Principal Investigator
      NIH/NCI R01CA037139Apr 1, 1984 - Jun 30, 1996
      Role: Principal Investigator
      Specialized Cancer Center Support Grant
      NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey R, Trottier J, Barbier O, Chen S. Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017 Jul; 45(7):748-754. PMID: 28468837.
        View in: PubMed
      2. Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey R. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 2017 Apr 19; 7:46489. PMID: 28422158.
        View in: PubMed
      3. Yueh MF, Chen S, Nguyen N, Tukey R. Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia. Mol Pharmacol. 2017 May; 91(5):545-553. PMID: 28283555.
        View in: PubMed
      4. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey R. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. PMID: 28167773.
        View in: PubMed
      5. Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey R, Fujiwara R. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 2016 Sep; 90(3):265-74. PMID: 27413119; PMCID: PMC4998668 [Available on 09/01/17].
      6. Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey R, Laurent LC. Stage-specific regulation of the WNT/ß-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 Jun; 64(6):1315-26. PMID: 26921690; PMCID: PMC5010388.
      7. Yueh MF, Tukey R. Triclosan: A Widespread Environmental Toxicant with Many Biological Effects. Annu Rev Pharmacol Toxicol. 2016; 56:251-72. PMID: 26738475; PMCID: PMC4774862 [Available on 01/06/17].
      8. Mitsugi R, Sumida K, Fujie Y, Tukey R, Itoh T, Fujiwara R. Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biol Pharm Bull. 2016; 39(10):1604-1610. PMID: 27725437.
        View in: PubMed
      9. Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey R, Brites D. Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia. Mol Pharmacol. 2016 Jan; 89(1):84-93. PMID: 26480925; PMCID: PMC4702100 [Available on 01/01/17].
      10. Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey R. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):63-76.e5. PMID: 26807433.
        View in: PubMed
      11. Fujiwara R, Maruo Y, Chen S, Tukey R. Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015 Nov 15; 289(1):124-32. PMID: 26342858; PMCID: PMC4708261 [Available on 11/15/16].
      12. Sakamoto M, Itoh T, Tukey R, Fujiwara R. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet. 2015 Aug; 30(4):269-75. PMID: 26210671; PMCID: PMC4752199.
      13. Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey R, Fujiwara R. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos. 2015 Jul; 43(7):1071-6. PMID: 25953521; PMCID: PMC4468441.
      14. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey R. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. PMID: 25404284; PMCID: PMC4260592.
      15. Kutsuno Y, Itoh T, Tukey R, Fujiwara R. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos. 2014 Jul; 42(7):1146-52. PMID: 24764149; PMCID: PMC4053997.
      16. Yueh MF, Chen S, Nguyen N, Tukey R. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014 Feb 21; 289(8):4699-709. PMID: 24403077; PMCID: PMC3931032.
      17. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey R. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. PMID: 24191041; PMCID: PMC3839688.
      18. Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey R, Fujiwara R. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol Pharmacol. 2013 Nov; 84(5):679-86. PMID: 23950218; PMCID: PMC3807078.
      19. Konopnicki CM, Dickmann LJ, Tracy JM, Tukey R, Wienkers LC, Foti RS. Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys. 2013 Jul 15; 535(2):143-9. PMID: 23562620; PMCID: PMC4059507.
      20. Yueh MF, Li T, Evans RM, Hammock B, Tukey R. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 2012; 7(6):e37705. PMID: 22761658; PMCID: PMC3376094.
      21. Chen S, Yueh MF, Evans RM, Tukey R. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67. PMID: 22371261; PMCID: PMC3383890.
      22. Fujiwara R, Chen S, Karin M, Tukey R. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-?B leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. PMID: 21983082; PMCID: PMC3428231.
      23. Vogel A, Ockenga J, Tukey R, Manns MP, Strassburg CP. Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited. Gastroenterology. 2011 May; 140(5):1692-3. PMID: 21440586.
        View in: PubMed
      24. Fujiwara R, Nguyen N, Chen S, Tukey R. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5024-9. PMID: 20194756; PMCID: PMC2841904.
      25. Savas U, Machemer DE, Hsu MH, Gaynor P, Lasker JM, Tukey R, Johnson EF. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem. 2009 Jun 12; 284(24):16541-52. PMID: 19366684; PMCID: PMC2713544.
      26. Chouinard S, Yueh MF, Tukey R, Giton F, Fiet J, Pelletier G, Barbier O, Bélanger A. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. J Steroid Biochem Mol Biol. 2008 Apr; 109(3-5):247-53. PMID: 18467088.
        View in: PubMed
      27. Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey R. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11. PMID: 18180294.
        View in: PubMed
      28. Bonzo JA, Bélanger A, Tukey R. The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology. 2007 Feb; 45(2):349-60. PMID: 17256720.
        View in: PubMed
      29. Yueh MF, Tukey R. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem. 2007 Mar 23; 282(12):8749-58. PMID: 17259171.
        View in: PubMed
      30. Pezzoli K, Tukey R, Sarabia H, Zaslavsky I, Miranda ML, Suk WA, Lin A, Ellisman M. The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities. Environ Health Perspect. 2007 Apr; 115(4):564-71. PMID: 17450225; PMCID: PMC1852670.
      31. Operaña TN, Tukey R. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007 Feb 16; 282(7):4821-9. PMID: 17179145.
        View in: PubMed
      32. Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey R. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar; 35(3):419-27. PMID: 17151188.
        View in: PubMed
      33. Operaña TN, Nguyen N, Chen S, Beaton D, Tukey R. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci. 2007 Jan; 95(1):98-107. PMID: 17065433.
        View in: PubMed
      34. Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey R. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11; 280(45):37547-57. PMID: 16155002.
        View in: PubMed
      35. Machemer DE, Tukey R. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci. 2005 Sep; 87(1):27-37. PMID: 15947024.
        View in: PubMed
      36. Bonzo JA, Chen S, Galijatovic A, Tukey R. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol. 2005 Apr; 67(4):1247-56. PMID: 15630080.
        View in: PubMed
      37. Yueh MF, Bonzo JA, Tukey R. The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1. Methods Enzymol. 2005; 400:75-91. PMID: 16399344.
        View in: PubMed
      38. Chen S, Operaña T, Bonzo J, Nguyen N, Tukey R. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem. 2005 Feb 11; 280(6):4350-9. PMID: 15572374.
        View in: PubMed
      39. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey R. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. PMID: 15037607.
        View in: PubMed
      40. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey R, Evans RM. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4150-5. PMID: 12644700; PMCID: PMC153063.
      41. Chen S, Nguyen N, Tamura K, Karin M, Tukey R. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. PMID: 12637498.
        View in: PubMed
      42. Yueh MF, Huang YH, Hiller A, Chen S, Nguyen N, Tukey R. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 2003 Apr 25; 278(17):15001-6. PMID: 12566446.
        View in: PubMed
      43. Tukey R, Strassburg CP, Mackenzie PI. Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity. Mol Pharmacol. 2002 Sep; 62(3):446-50. PMID: 12181419.
        View in: PubMed
      44. Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey R. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenetics. 2002 Jun; 12(4):287-97. PMID: 12042666.
        View in: PubMed
      45. Strassburg A, Strassburg CP, Manns MP, Tukey R. Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue. Mol Pharmacol. 2002 Feb; 61(2):320-5. PMID: 11809856.
        View in: PubMed
      46. Tukey R, Strassburg CP. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol. 2001 Mar; 59(3):405-14. PMID: 11179432.
        View in: PubMed
      47. Tukey R, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000; 40:581-616. PMID: 10836148.
        View in: PubMed
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