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    Monica Guma

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0663
    CA La Jolla 92093
    Phone858-822-6523
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      Collapse Research 
      Collapse Research Activities and Funding
      Choline metabolites as biomarkers in rheumatoid arthritis
      NIH R03AR068094Mar 1, 2015 - Jan 31, 2018
      Role: Principal Investigator
      Choline kinase: a novel target for rheumatoid arthritis
      NIH K08AR064834Sep 1, 2013 - Aug 31, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bustamante MF, Garcia-Carbonell R, Whisenant KD, Guma M. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 2017 May 31; 19(1):110. PMID: 28569176.
        View in: PubMed
      2. Smith CJF, Friedlander SF, Guma M, Kavanaugh A, Chambers CD. Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment. Birth Defects Res. 2017 Jul 03; 109(11):809-815. PMID: 28402073.
        View in: PubMed
      3. Viger ML, Collet G, Lux J, Nguyen Huu VA, Guma M, Foucault-Collet A, Olejniczak J, Joshi-Barr S, Firestein GS, Almutairi A. Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast. Biomaterials. 2017 Jul; 133:119-131. PMID: 28433935.
        View in: PubMed
      4. Sweeney SR, Kavanaugh A, Lodi A, Wang B, Boyle D, Tiziani S, Guma M. Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. RMD Open. 2016; 2(2):e000289. PMID: 27651926; PMCID: PMC5013418.
      5. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 Jul; 68(7):1614-26. PMID: 26815411.
        View in: PubMed
      6. Guma M, Tiziani S, Firestein GS. Metabolomics in rheumatic diseases: desperately seeking biomarkers. Nat Rev Rheumatol. 2016 May; 12(5):269-81. PMID: 26935283.
        View in: PubMed
      7. Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38a-Dependent Restraint of NF-?B Signaling. J Immunol. 2016 Mar 1; 196(5):2368-76. PMID: 26792803.
        View in: PubMed
      8. Guma M, Wang Y, Viollet B, Liu-Bryan R. AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis. PLoS One. 2015; 10(10):e0140452. PMID: 26474486.
        View in: PubMed
      9. Shaked H, Guma M, Karin M. Analysis of NF-?B Activation in Mouse Intestinal Epithelial Cells. Methods Mol Biol. 2015; 1280:593-606. PMID: 25736774.
        View in: PubMed
      10. Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407. PMID: 25274633.
        View in: PubMed
      11. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2377-82. PMID: 23341606.
        View in: PubMed
      12. Guma M, Firestein GS. c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. Open Rheumatol J. 2012; 6:220-31. PMID: 23028407.
        View in: PubMed
      13. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. PMID: 22488549.
        View in: PubMed
      14. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-?B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12. PMID: 22893683.
        View in: PubMed
      15. Guma M, Firestein GS. IgG4-related diseases. Best Pract Res Clin Rheumatol. 2012 Aug; 26(4):425-38. PMID: 23040358.
        View in: PubMed
      16. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. PMID: 21825016.
        View in: PubMed
      17. Romo N, Magri G, Muntasell A, Heredia G, Baía D, Angulo A, Guma M, López-Botet M. Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization. J Leukoc Biol. 2011 Oct; 90(4):717-26. PMID: 21742939.
        View in: PubMed
      18. Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12. PMID: 21305529.
        View in: PubMed
      19. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 4; 108(1):308-13. PMID: 21173249.
        View in: PubMed
      20. Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7. PMID: 21135226.
        View in: PubMed
      21. Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50. PMID: 19950258.
        View in: PubMed
      22. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. PMID: 19433784.
        View in: PubMed
      23. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 5; 453(7196):807-11. PMID: 18432192.
        View in: PubMed
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