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    Mohit Jain

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0613
    CA La Jolla 92093
    Phone858-822-5854
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      Collapse Biography 
      Collapse Education and Training
      School of MedicineM.D., Ph.D.Boston University

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Mapping the Plasma Exposome and its Association with Human Cardiovascular Disease
      NIH/NIEHS R01ES027595Feb 1, 2017 - Jan 31, 2022
      Role: Principal Investigator
      Mapping metabolic activities in stem cell-derived models of human cardiomyopathy
      NIH/NHLBI R03HL133720Aug 15, 2016 - Jul 31, 2018
      Role: Principal Investigator
      Reactive electrophiles in human aging and longevity
      NIH/NIA R03AG053287Aug 1, 2016 - Apr 30, 2018
      Role: Principal Investigator
      RapidFire mass spectrometry system
      NIH S10OD020025Apr 17, 2015 - Apr 16, 2016
      Role: Principal Investigator
      A systems approach to metabolic dysregulation in the heart
      NIH/NHLBI K08HL107451Apr 22, 2011 - Mar 31, 2016
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain M, Subramaniam S, Shyy JY. KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Aug 09. PMID: 28794002.
        View in: PubMed
      2. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Inhibition of IKK? and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. PMID: 28683283.
        View in: PubMed
      3. Lyutvinskiy Y, Watrous JD, Jain M, Nilsson R. A Web Service Framework for Interactive Analysis of Metabolomics Data. Anal Chem. 2017 Jun 06; 89(11):5713-5718. PMID: 28514166.
        View in: PubMed
      4. Shin CS, Mishra P, Watrous JD, Carelli V, D'Aurelio M, Jain M, Chan DC. The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun. 2017 Apr 21; 8:15074. PMID: 28429737.
        View in: PubMed
      5. Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, Illig T, Rhee EP, Srinivas PR, Wang TJ, Jain M. Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Apr; 10(2). PMID: 28360086.
        View in: PubMed
      6. Nilsson R, Roci I, Watrous J, Jain M. Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism. Metab Eng. 2017 Sep; 43(Pt B):137-146. PMID: 28232235.
        View in: PubMed
      7. Roci I, Gallart-Ayala H, Watrous J, Jain M, Wheelock CE, Nilsson R. A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing. J Vis Exp. 2017 Feb 04; (120). PMID: 28190056.
        View in: PubMed
      8. Watrous JD, Henglin M, Claggett B, Lehmann KA, Larson MG, Cheng S, Jain M. Visualization, Quantification, and Alignment of Spectral Drift in Population Scale Untargeted Metabolomics Data. Anal Chem. 2017 Feb 07; 89(3):1399-1404. PMID: 28208263.
        View in: PubMed
      9. Sapp V, Jain M, Liao R. Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy. Physiology (Bethesda). 2016 07; 31(4):294-9. PMID: 27252164.
        View in: PubMed
      10. Roci I, Gallart-Ayala H, Schmidt A, Watrous J, Jain M, Wheelock CE, Nilsson R. Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells. Anal Chem. 2016 Mar 01; 88(5):2707-13. PMID: 26855138.
        View in: PubMed
      11. Ivanisevic J, Elias D, Deguchi H, Averell PM, Kurczy M, Johnson CH, Tautenhahn R, Zhu Z, Watrous J, Jain M, Griffin J, Patti GJ, Siuzdak G. Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis. Sci Rep. 2015 Aug 05; 5:12757. PMID: 26244428; PMCID: PMC4525490.
        View in: PubMed, PubMed Central
      12. Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15; 306(8):E854-68. PMID: 24518676; PMCID: PMC3989739.
        View in: PubMed, PubMed Central
      13. Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, Bauer M, Su L, Burkly LC, Leone TC, Kelly DP, Liao R. PGC1a plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One. 2013; 8(1):e54054. PMID: 23342071; PMCID: PMC3546975.
        View in: PubMed, PubMed Central
      14. Unno K, Jain M, Liao R. Cardiac side population cells: moving toward the center stage in cardiac regeneration. Circ Res. 2012 May 11; 110(10):1355-63. PMID: 22581921; PMCID: PMC3412159.
        View in: PubMed, PubMed Central
      15. Bauer M, Cheng S, Jain M, Ngoy S, Theodoropoulos C, Trujillo A, Lin FC, Liao R. Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res. 2011 Apr 15; 108(8):908-16. PMID: 21372284; PMCID: PMC3376717.
        View in: PubMed, PubMed Central
      16. Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009 Dec; 297(6):H2144-53. PMID: 19801492; PMCID: PMC2793140.
        View in: PubMed, PubMed Central
      17. Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, Guan J, Lim CC, Naito Y, Thompson JS, Sam F, Ambrose C, Parr M, Crowell T, Lincecum JM, Wang MZ, Hsu YM, Zheng TS, Michaelson JS, Liao R, Burkly LC. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009 Apr 21; 119(15):2058-68. PMID: 19349318; PMCID: PMC2924152.
        View in: PubMed, PubMed Central
      18. Luptak I, Yan J, Cui L, Jain M, Liao R, Tian R. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 2007 Aug 21; 116(8):901-9. PMID: 17679614.
        View in: PubMed
      19. Liao R, Pfister O, Jain M, Mouquet F. The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis. 2007 Jul-Aug; 50(1):18-30. PMID: 17631435; PMCID: PMC2096729.
        View in: PubMed, PubMed Central
      20. Sohn RL, Jain M, Liao R. Adult stem cells and heart regeneration. Expert Rev Cardiovasc Ther. 2007 May; 5(3):507-17. PMID: 17489674.
        View in: PubMed
      21. Liao R, Jain M. Isolation, culture, and functional analysis of adult mouse cardiomyocytes. Methods Mol Med. 2007; 139:251-62. PMID: 18287677.
        View in: PubMed
      22. Mouquet F, Pfister O, Jain M, Oikonomopoulos A, Ngoy S, Summer R, Fine A, Liao R. Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res. 2005 Nov 25; 97(11):1090-2. PMID: 16269652.
        View in: PubMed
      23. Pfister O, Jain M, Liao R. Cell therapy in heart failure. Heart Fail Clin. 2005 Jul; 1(2):303-12. PMID: 17386854.
        View in: PubMed
      24. Pfister O, Mouquet F, Jain M, Summer R, Helmes M, Fine A, Colucci WS, Liao R. CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res. 2005 Jul 08; 97(1):52-61. PMID: 15947249.
        View in: PubMed
      25. Jain M, Pfister O, Hajjar RJ, Liao R. Mesenchymal stem cells in the infarcted heart. Coron Artery Dis. 2005 Mar; 16(2):93-7. PMID: 15735401.
        View in: PubMed
      26. Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res. 2004 Apr 30; 94(8):1008-10. PMID: 15044325.
        View in: PubMed
      27. Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903. PMID: 14757696.
        View in: PubMed
      28. Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16. PMID: 12829617.
        View in: PubMed
      29. Liao R, Jain M, Cui L, D'Agostino J, Aiello F, Luptak I, Ngoy S, Mortensen RM, Tian R. Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 2002 Oct 15; 106(16):2125-31. PMID: 12379584.
        View in: PubMed
      30. Jain M, Liao R, Podesser BK, Ngoy S, Apstein CS, Eberli FR. Influence of gender on the response to hemodynamic overload after myocardial infarction. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2544-50. PMID: 12388328.
        View in: PubMed
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