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Mohit Jain

Title(s)Associate Professor, Pharmacology
SchoolHealth Sciences
Phone858-822-5854
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    Collapse Biography 
    Collapse Education and Training
    School of MedicineM.D., Ph.D.Boston University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Mapping the Plasma Exposome and its Association with Human Cardiovascular Disease
    NIH/NIEHS R01ES027595Feb 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Mapping metabolic activities in stem cell-derived models of human cardiomyopathy
    NIH/NHLBI R03HL133720Aug 15, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Reactive electrophiles in human aging and longevity
    NIH/NIA R03AG053287Aug 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    RapidFire mass spectrometry system
    NIH S10OD020025Apr 17, 2015 - Apr 16, 2016
    Role: Principal Investigator
    A systems approach to metabolic dysregulation in the heart
    NIH/NHLBI K08HL107451Apr 22, 2011 - Mar 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 Jul; 68(7):1415-1426. PMID: 31010956.
      View in: PubMed
    2. Coras R, Kavanaugh A, Boyd T, Huynh Q, Pedersen B, Armando AM, Dahlberg-Wright S, Marsal S, Jain M, Paravar T, Quehenberger O, Guma M. Pro- and anti-inflammatory eicosanoids in psoriatic arthritis. Metabolomics. 2019 Apr 19; 15(4):65. PMID: 31004236.
      View in: PubMed
    3. Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L. Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep. 2019 Apr; 20(4). PMID: 30886000.
      View in: PubMed
    4. Roci I, Watrous JD, Lagerborg KA, Lafranchi L, Lindqvist A, Jain M, Nilsson R. Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase. Cell Rep. 2019 Feb 12; 26(7):1691-1700.e5. PMID: 30759381.
      View in: PubMed
    5. Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 Mar 21; 26(3):433-442.e4. PMID: 30661990.
      View in: PubMed
    6. Coras R, Kavanaugh A, Boyd T, Huynh D, Lagerborg KA, Xu YJ, Rosenthal SB, Jain M, Guma M. Choline metabolite, trimethylamine N-oxide (TMAO), is associated with inflammation in psoriatic arthritis. Clin Exp Rheumatol. 2019 Jan 04. PMID: 30620278.
      View in: PubMed
    7. Lagerborg KA, Watrous JD, Cheng S, Jain M. High-Throughput Measure of Bioactive Lipids Using Non-targeted Mass Spectrometry. Methods Mol Biol. 2019; 1862:17-35. PMID: 30315457.
      View in: PubMed
    8. Grankvist N, Lagerborg KA, Jain M, Nilsson R. Gabapentin Can Suppress Cell Proliferation Independent of the Cytosolic Branched-Chain Amino Acid Transferase 1 (BCAT1). Biochemistry. 2018 Nov 26. PMID: 30427175.
      View in: PubMed
    9. Grankvist N, Watrous JD, Lagerborg KA, Lyutvinskiy Y, Jain M, Nilsson R. Profiling the Metabolism of Human Cells by Deep 13C Labeling. Cell Chem Biol. 2018 Nov 15; 25(11):1419-1427.e4. PMID: 30270114.
      View in: PubMed
    10. Basu Ball W, Baker CD, Neff JK, Apfel GL, Lagerborg KA, Žun G, Petrovic U, Jain M, Gohil VM. Ethanolamine ameliorates mitochondrial dysfunction in cardiolipin-deficient yeast cells. J Biol Chem. 2018 07 13; 293(28):10870-10883. PMID: 29866881.
      View in: PubMed
    11. Garratt M, Lagerborg KA, Tsai YM, Galecki A, Jain M, Miller RA. Male lifespan extension with 17-a estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice. Aging Cell. 2018 May 27; e12786. PMID: 29806096.
      View in: PubMed
    12. Echouffo-Tcheugui JB, Niiranen TJ, McCabe EL, Jain M, Vasan RS, Larson MG, Cheng S. Lifetime Prevalence and Prognosis of Prediabetes Without Progression to Diabetes. Diabetes Care. 2018 07; 41(7):e117-e118. PMID: 29724784.
      View in: PubMed
    13. Niiranen TJ, Henglin M, Claggett B, Muggeo VMR, McCabe E, Jain M, Vasan RS, Larson MG, Cheng S. Trajectories of Blood Pressure Elevation Preceding Hypertension Onset: An Analysis of the Framingham Heart Study Original Cohort. JAMA Cardiol. 2018 May 01; 3(5):427-431. PMID: 29562081.
      View in: PubMed
    14. Suarez J, Cividini F, Scott BT, Lehmann K, Diaz-Juarez J, Diemer T, Dai A, Suarez JA, Jain M, Dillmann WH. Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function. J Biol Chem. 2018 05 25; 293(21):8182-8195. PMID: 29626093.
      View in: PubMed
    15. Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmström A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC. Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Stem Cell Reports. 2018 02 13; 10(2):422-435. PMID: 29398480.
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    16. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY. Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Oct 03; 136(14):1315-1330. PMID: 28794002.
      View in: PubMed
    17. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Inhibition of IKK? and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. PMID: 28683283.
      View in: PubMed
    18. Chowdhary V, Vajpeyajula R, Jain M, Maqsood S, Raina R, Kumar D, Mhanna MJ. Comparison of different definitions of acute kidney injury in extremely low birth weight infants. Clin Exp Nephrol. 2018 Feb; 22(1):117-125. PMID: 28616708.
      View in: PubMed
    19. Lyutvinskiy Y, Watrous JD, Jain M, Nilsson R. A Web Service Framework for Interactive Analysis of Metabolomics Data. Anal Chem. 2017 06 06; 89(11):5713-5718. PMID: 28514166.
      View in: PubMed
    20. Mhanna MJ, Iyer NP, Piraino S, Jain M. Respiratory severity score and extubation readiness in very low birth weight infants. Pediatr Neonatol. 2017 12; 58(6):523-528. PMID: 28539199.
      View in: PubMed
    21. Shin CS, Mishra P, Watrous JD, Carelli V, D'Aurelio M, Jain M, Chan DC. The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun. 2017 04 21; 8:15074. PMID: 28429737.
      View in: PubMed
    22. Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, Illig T, Rhee EP, Srinivas PR, Wang TJ, Jain M. Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Apr; 10(2). PMID: 28360086.
      View in: PubMed
    23. Nilsson R, Roci I, Watrous J, Jain M. Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism. Metab Eng. 2017 09; 43(Pt B):137-146. PMID: 28232235.
      View in: PubMed
    24. Roci I, Gallart-Ayala H, Watrous J, Jain M, Wheelock CE, Nilsson R. A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing. J Vis Exp. 2017 02 04; (120). PMID: 28190056.
      View in: PubMed
    25. Watrous JD, Henglin M, Claggett B, Lehmann KA, Larson MG, Cheng S, Jain M. Visualization, Quantification, and Alignment of Spectral Drift in Population Scale Untargeted Metabolomics Data. Anal Chem. 2017 02 07; 89(3):1399-1404. PMID: 28208263.
      View in: PubMed
    26. Sapp V, Jain M, Liao R. Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy. Physiology (Bethesda). 2016 07; 31(4):294-9. PMID: 27252164.
      View in: PubMed
    27. Roci I, Gallart-Ayala H, Schmidt A, Watrous J, Jain M, Wheelock CE, Nilsson R. Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells. Anal Chem. 2016 Mar 01; 88(5):2707-13. PMID: 26855138.
      View in: PubMed
    28. Chen H, Ren S, Clish C, Jain M, Mootha V, McCaffery JM, Chan DC. Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy. J Cell Biol. 2015 Nov 23; 211(4):795-805. PMID: 26598616; PMCID: PMC4657172.
      View in: PubMed, PubMed Central
    29. Liu T, Wu C, Jain MR, Nagarajan N, Yan L, Dai H, Cui C, Baykal A, Pan S, Ago T, Sadoshima J, Li H. Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation. Biochim Biophys Acta. 2015 Dec; 1854(12):1816-1822. PMID: 26410624.
      View in: PubMed
    30. Ivanisevic J, Elias D, Deguchi H, Averell PM, Kurczy M, Johnson CH, Tautenhahn R, Zhu Z, Watrous J, Jain M, Griffin J, Patti GJ, Siuzdak G. Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis. Sci Rep. 2015 Aug 05; 5:12757. PMID: 26244428; PMCID: PMC4525490.
      View in: PubMed, PubMed Central
    31. Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW. The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition. Cell Rep. 2015 Jul 07; 12(1):23-34. PMID: 26119731; PMCID: PMC4517182.
      View in: PubMed, PubMed Central
    32. Wu C, Jain MR, Li Q, Oka S, Li W, Kong AN, Nagarajan N, Sadoshima J, Simmons WJ, Li H. Identification of novel nuclear targets of human thioredoxin 1. Mol Cell Proteomics. 2014 Dec; 13(12):3507-18. PMID: 25231459; PMCID: PMC4256501.
      View in: PubMed, PubMed Central
    33. Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP, Sadoshima J. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol Cell. 2014 May 22; 54(4):639-50. PMID: 24813943; PMCID: PMC4074544.
      View in: PubMed, PubMed Central
    34. Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15; 306(8):E854-68. PMID: 24518676; PMCID: PMC3989739.
      View in: PubMed, PubMed Central
    35. Mémin E, Hoque M, Jain MR, Heller DS, Li H, Cracchiolo B, Hanauske-Abel HM, Pe'ery T, Mathews MB. Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation. Cancer Res. 2014 Jan 15; 74(2):552-62. PMID: 24220243; PMCID: PMC4745653.
      View in: PubMed, PubMed Central
    36. Gohil VM, Zhu L, Baker CD, Cracan V, Yaseen A, Jain M, Clish CB, Brookes PS, Bakovic M, Mootha VK. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J Biol Chem. 2013 Dec 06; 288(49):35387-95. PMID: 24142790; PMCID: PMC3853286.
      View in: PubMed, PubMed Central
    37. Li H, Liu T, Chen W, Jain MR, Vatner DE, Vatner SF, Kudej RK, Yan L. Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax. J Proteome Res. 2013 Sep 06; 12(9):4221-9. PMID: 23855383.
      View in: PubMed
    38. Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG. An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature. 2013 Jul 11; 499(7457):238-42. PMID: 23792561; PMCID: PMC3846693.
      View in: PubMed, PubMed Central
    39. Li Q, Jain MR, Chen W, Li H. A multidimensional approach to an in-depth proteomics analysis of transcriptional regulators in neuroblastoma cells. J Neurosci Methods. 2013 Jun 15; 216(2):118-27. PMID: 23558336; PMCID: PMC3679315.
      View in: PubMed, PubMed Central
    40. Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, Bauer M, Su L, Burkly LC, Leone TC, Kelly DP, Liao R. PGC1a plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One. 2013; 8(1):e54054. PMID: 23342071; PMCID: PMC3546975.
      View in: PubMed, PubMed Central
    41. Fakira AK, Gaspers LD, Thomas AP, Li H, Jain MR, Elkabes S. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. Mol Cell Neurosci. 2012 Aug; 51(1-2):22-31. PMID: 22789621; PMCID: PMC3436994.
      View in: PubMed, PubMed Central
    42. Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012 May 25; 336(6084):1040-4. PMID: 22628656.
      View in: PubMed
    43. Unno K, Jain M, Liao R. Cardiac side population cells: moving toward the center stage in cardiac regeneration. Circ Res. 2012 May 11; 110(10):1355-63. PMID: 22581921; PMCID: PMC3412159.
      View in: PubMed, PubMed Central
    44. Jain MR, Li Q, Liu T, Rinaggio J, Ketkar A, Tournier V, Madura K, Elkabes S, Li H. Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitis. J Proteome Res. 2012 Mar 02; 11(3):1791-803. PMID: 22188123; PMCID: PMC3312875.
      View in: PubMed, PubMed Central
    45. Wu C, Parrott AM, Liu T, Jain MR, Yang Y, Sadoshima J, Li H. Distinction of thioredoxin transnitrosylation and denitrosylation target proteins by the ICAT quantitative approach. J Proteomics. 2011 Oct 19; 74(11):2498-509. PMID: 21704743; PMCID: PMC3253718.
      View in: PubMed, PubMed Central
    46. Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H. Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. Antioxid Redox Signal. 2011 Nov 01; 15(9):2565-604. PMID: 21453190; PMCID: PMC3176348.
      View in: PubMed, PubMed Central
    47. Jain MR, Li M, Chen W, Liu T, de Toledo SM, Pandey BN, Li H, Rabin BM, Azzam EI. In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria. Curr Mol Pharmacol. 2011 Jun; 4(2):106-14. PMID: 21166651; PMCID: PMC3330755.
      View in: PubMed, PubMed Central
    48. Bauer M, Cheng S, Jain M, Ngoy S, Theodoropoulos C, Trujillo A, Lin FC, Liao R. Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res. 2011 Apr 15; 108(8):908-16. PMID: 21372284; PMCID: PMC3376717.
      View in: PubMed, PubMed Central
    49. Wu C, Liu T, Chen W, Oka S, Fu C, Jain MR, Parrott AM, Baykal AT, Sadoshima J, Li H. Redox regulatory mechanism of transnitrosylation by thioredoxin. Mol Cell Proteomics. 2010 Oct; 9(10):2262-75. PMID: 20660346; PMCID: PMC2953919.
      View in: PubMed, PubMed Central
    50. Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009 Dec; 297(6):H2144-53. PMID: 19801492; PMCID: PMC2793140.
      View in: PubMed, PubMed Central
    51. Jain MR, Bian S, Liu T, Hu J, Elkabes S, Li H. Altered proteolytic events in experimental autoimmune encephalomyelitis discovered by iTRAQ shotgun proteomics analysis of spinal cord. Proteome Sci. 2009 Jul 16; 7:25. PMID: 19607715; PMCID: PMC2716311.
      View in: PubMed, PubMed Central
    52. Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, Guan J, Lim CC, Naito Y, Thompson JS, Sam F, Ambrose C, Parr M, Crowell T, Lincecum JM, Wang MZ, Hsu YM, Zheng TS, Michaelson JS, Liao R, Burkly LC. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009 Apr 21; 119(15):2058-68. PMID: 19349318; PMCID: PMC2924152.
      View in: PubMed, PubMed Central
    53. Baykal AT, Jain MR, Li H. Aberrant regulation of choline metabolism by mitochondrial electron transport system inhibition in neuroblastoma cells. Metabolomics. 2008 Dec 01; 4(4):347-356. PMID: 19774105.
      View in: PubMed
    54. Jain MR, Ge WW, Elkabes S, Li H. Amyotrophic lateral sclerosis: Protein chaperone dysfunction revealed by proteomic studies of animal models. Proteomics Clin Appl. 2008 May 01; 2(5):670-684. PMID: 19578526.
      View in: PubMed
    55. Jain MR, Liu T, Hu J, Darfler M, Fitzhugh V, Rinaggio J, Li H. Quantitative Proteomic Analysis of Formalin Fixed Paraffin Embedded Oral HPV Lesions from HIV Patients. Open Proteomics J. 2008; 1:40-45. PMID: 19081750.
      View in: PubMed
    56. Luptak I, Yan J, Cui L, Jain M, Liao R, Tian R. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 2007 Aug 21; 116(8):901-9. PMID: 17679614.
      View in: PubMed
    57. Liao R, Pfister O, Jain M, Mouquet F. The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis. 2007 Jul-Aug; 50(1):18-30. PMID: 17631435; PMCID: PMC2096729.
      View in: PubMed, PubMed Central
    58. Grant JE, Hu J, Liu T, Jain MR, Elkabes S, Li H. Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis. J Proteome Res. 2007 Jul; 6(7):2786-91. PMID: 17567059; PMCID: PMC2435290.
      View in: PubMed, PubMed Central
    59. Sohn RL, Jain M, Liao R. Adult stem cells and heart regeneration. Expert Rev Cardiovasc Ther. 2007 May; 5(3):507-17. PMID: 17489674.
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    60. Liao R, Jain M. Isolation, culture, and functional analysis of adult mouse cardiomyocytes. Methods Mol Med. 2007; 139:251-62. PMID: 18287677.
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    61. Mouquet F, Pfister O, Jain M, Oikonomopoulos A, Ngoy S, Summer R, Fine A, Liao R. Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res. 2005 Nov 25; 97(11):1090-2. PMID: 16269652.
      View in: PubMed
    62. Pfister O, Jain M, Liao R. Cell therapy in heart failure. Heart Fail Clin. 2005 Jul; 1(2):303-12. PMID: 17386854.
      View in: PubMed
    63. Pfister O, Mouquet F, Jain M, Summer R, Helmes M, Fine A, Colucci WS, Liao R. CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res. 2005 Jul 08; 97(1):52-61. PMID: 15947249.
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    64. Jain M, Pfister O, Hajjar RJ, Liao R. Mesenchymal stem cells in the infarcted heart. Coron Artery Dis. 2005 Mar; 16(2):93-7. PMID: 15735401.
      View in: PubMed
    65. Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res. 2004 Apr 30; 94(8):1008-10. PMID: 15044325.
      View in: PubMed
    66. Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903. PMID: 14757696.
      View in: PubMed
    67. Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16. PMID: 12829617.
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    68. Liao R, Jain M, Cui L, D'Agostino J, Aiello F, Luptak I, Ngoy S, Mortensen RM, Tian R. Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 2002 Oct 15; 106(16):2125-31. PMID: 12379584.
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    69. Jain M, Liao R, Podesser BK, Ngoy S, Apstein CS, Eberli FR. Influence of gender on the response to hemodynamic overload after myocardial infarction. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2544-50. PMID: 12388328.
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