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    Jerrold Olefsky

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0673
    CA La Jolla 92093
    Phone858-534-6651
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Effects of Fractalkine on Beta Cell Function
      NIH/NIDDK R01DK101395Sep 19, 2014 - Aug 31, 2018
      Role: Principal Investigator
      Energetics &Breast Cancer: Obesity, Inflammation, Insulin Resistance &Risk
      NIH/NCI U54CA155435Jul 7, 2011 - May 31, 2016
      Role: Co-Investigator
      Molecular Mechanisms of Inflammation, Steatosis and Hepatic Insulin Resistance
      NIH/NIDDK R24DK090962Sep 30, 2010 - Aug 31, 2012
      Role: Principal Investigator
      Gene Networks controlling macrophage-adipocyte interactions in insulin
      NIH/NIDDK P01DK074868Apr 1, 2006 - Apr 30, 2017
      Role: Co-Investigator
      Estrogen Effects in Insulin Target and Granulosa Cells
      NIH/NIDDK R55DK068606Sep 30, 2004 - Aug 31, 2006
      Role: Principal Investigator
      Diabetes Research Center (DRC)
      NIH/NIDDK P30DK063491Dec 1, 2002 - Apr 30, 2018
      Role: Principal Investigator
      Estrogens and Insulin Resistance in Women
      NIH/NIDDK R01DK061964Jul 1, 2002 - May 31, 2007
      Role: Principal Investigator
      PKA & PKC Targeting Mechanisms (Program Project)
      NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
      Role: Co-Investigator
      Diabetes Prevention Program Outcomes Study (DPPOS) Phase 3 ? Research Project
      NIH/NIDDK U01DK048339Sep 10, 1994 - Jan 31, 2021
      Role: Principal Investigator
      TRAINING PROGRAM IN DIABETES RESEARCH
      NIH/NIDDK T32DK007494Jul 1, 1984 - Aug 31, 2022
      Role: Principal Investigator
      TRAINING PROGRAM IN DIABETES RESEARCH
      NIH/NIADDK T32AM007494Jul 1, 1984 - Jun 30, 1989
      Role: Principal Investigator
      Insulin Receptors and the Glucose Transport System
      NIH/NIDDK R01DK033651Aug 1, 1983 - Jun 30, 2014
      Role: Principal Investigator
      INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
      NIH/NIDDK R37DK033651Aug 1, 1983 - Jun 30, 2010
      Role: Principal Investigator
      MECHANISMS OF INSULIN RESISTANCE IN MAN
      NIH/NIDDK R01DK033649Aug 1, 1983 - Mar 31, 2002
      Role: Principal Investigator
      MECHANISMS OF INSULIN RESISTANCE IN MAN
      NIH/NIDDK R37DK033649Aug 1, 1983 - Mar 31, 1998
      Role: Principal Investigator
      INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
      NIH/NIADDK R01AM033651Aug 1, 1983 - Mar 31, 1990
      Role: Principal Investigator
      MECHANISMS OF INSULIN RESISTANCE IN MAN
      NIH/NIADDK R01AM033649Aug 1, 1983 - May 31, 1989
      Role: Principal Investigator
      Center for Reproductive Science and Medicine
      NIH/NICHD U54HD012303Dec 1, 1978 - Mar 31, 2014
      Role: Co-Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Saltiel AR, Olefsky J. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 Jan 03; 127(1):1-4. PMID: 28045402.
        View in: PubMed
      2. Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky J, Webster NJ. Obese Neuronal PPAR? Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology. 2017 Jan 01; 158(1):121-133. PMID: 27841948.
        View in: PubMed
      3. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AM, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky J. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 Nov 03; 167(4):973-984.e12. PMID: 27814523.
        View in: PubMed
      4. Oh da Y, Olefsky J. G protein-coupled receptors as targets for anti-diabetic therapeutics. Nat Rev Drug Discov. 2016 Mar; 15(3):161-72. PMID: 26822831.
        View in: PubMed
      5. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky J, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707.
        View in: PubMed
      6. Lackey DE, Olefsky J. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016 Jan; 12(1):15-28. PMID: 26553134.
        View in: PubMed
      7. Kesby JP, Kim JJ, Scadeng M, Woods G, Kado DM, Olefsky J, Jeste DV, Achim CL, Semenova S. Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet. PLoS One. 2015; 10(10):e0140034. PMID: 26448649.
        View in: PubMed
      8. McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky J. GPR43 Potentiates ß-Cell Function in Obesity. Diabetes. 2015 Sep; 64(9):3203-17. PMID: 26023106.
        View in: PubMed
      9. Johnson AM, Costanzo A, Gareau MG, Armando AM, Quehenberger O, Jameson JM, Olefsky J. High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. PLoS One. 2015; 10(4):e0122195. PMID: 25837594.
        View in: PubMed
      10. Mayoral R, Osborn O, McNelis J, Johnson AM, Oh da Y, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky J. Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 May; 4(5):378-91. PMID: 25973386.
        View in: PubMed
      11. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky J, Saltiel AR, Downes M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. PMID: 25559344.
        View in: PubMed
      12. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky J, Oh DY. Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice. Diabetes. 2014 Oct 14. PMID: 25315009.
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      13. McNelis JC, Olefsky J. Macrophages, immunity, and metabolic disease. Immunity. 2014 Jul 17; 41(1):36-48. PMID: 25035952.
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      14. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky J, Mohammadi M, Downes M, Evans RM. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. PMID: 25043058.
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      15. Oh da Y, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky J. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug; 20(8):942-7. PMID: 24997608.
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      16. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug 1; 124(8):3566-78. PMID: 24983318.
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      17. Lee YS, Kim JW, Osborne O, Oh da Y, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky J. Increased Adipocyte O2 Consumption Triggers HIF-1a, Causing Inflammation and Insulin Resistance in Obesity. Cell. 2014 Jun 5; 157(6):1339-52. PMID: 24906151.
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      18. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky J, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027.
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      19. Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, Blüher M, Olefsky J, Sams A, Klip A. Pro-Inflammatory macrophages increase in skeletal muscle of high fat-Fed mice and correlate with metabolic risk markers in humans. Obesity (Silver Spring). 2014 Mar; 22(3):747-57. PMID: 24030890.
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      20. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh da Y, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky J. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26; 155(1):200-14. PMID: 24074869.
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      21. Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013 Oct 1; 123(10):4318-28. PMID: 24051374.
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      22. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky J, Taylor SS. Quantitative Proteomic and Functional Analysis of Liver Mitochondria from High Fat Diet (HFD) Diabetic Mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101.
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      23. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. PMID: 23582329.
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      24. Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky J, Webster NJ. Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LßT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice. Endocrinology. 2013 Jun; 154(6):2188-99. PMID: 23525221.
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      25. Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky J. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem. 2013 Apr 12; 288(15):10722-35. PMID: 23457303.
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      26. Johnson AM, Olefsky J. The origins and drivers of insulin resistance. Cell. 2013 Feb 14; 152(4):673-84. PMID: 23415219.
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      27. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky J, Saltiel AR. An inhibitor of the protein kinases TBK1 and IKK-? improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. PMID: 23396211.
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      28. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky J, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control. 2013 Apr; 24(4):695-704. PMID: 23378138.
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      29. Jiao J, Bae EJ, Bandyopadhyay G, Oliver J, Marathe C, Chen M, Hsu JY, Chen Y, Tian H, Olefsky J, Saberi M. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats. Diabetes. 2013 Apr; 62(4):1074-83. PMID: 23248171.
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      30. Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky J, Sears DD, Kaplan LM, Kemp DM. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013 Mar; 62(3):855-63. PMID: 23223024.
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      31. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 5; 16(3):311-21. PMID: 22958918.
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      32. Talukdar S, Oh da Y, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky J. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med. 2012 Sep; 18(9):1407-12. PMID: 22863787.
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      33. Xu J, Morinaga H, Oh D, Li P, Chen A, Talukdar S, Mamane Y, Mancini JA, Nawrocki AR, Lazarowski E, Olefsky J, Kim JJ. GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. J Immunol. 2012 Aug 15; 189(4):1992-9. PMID: 22778393.
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      34. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky J. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul 2; 122(7):2444-53. PMID: 22653059.
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      35. Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, Whyte J, He M, Juguilon H, Yin YQ, Phillips CT, Yu RT, Olefsky J, Henry RR, Downes M, Evans RM. A PPAR?-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature. 2012 May 17; 485(7398):391-4. PMID: 22522926.
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      36. Oh DY, Olefsky J. Omega 3 fatty acids and GPR120. Cell Metab. 2012 May 2; 15(5):564-5. PMID: 22560206.
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      37. Glass CK, Olefsky J. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012 May 2; 15(5):635-45. PMID: 22560216.
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      38. Kim JJ, Fan W, Olefsky J. Putting the brakes on FOXO1 in fat. EMBO J. 2012 May 16; 31(10):2240-1. PMID: 22510885.
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      39. Bae EJ, Xu J, Oh DY, Bandyopadhyay G, Lagakos WS, Keshwani M, Olefsky J. Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance. J Biol Chem. 2012 May 25; 287(22):18769-80. PMID: 22493495.
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      40. Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky J, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5838-43. PMID: 22460790.
        View in: PubMed
      41. Osborn O, Olefsky J. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012 Mar; 18(3):363-74. PMID: 22395709.
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      42. Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky J. Increased macrophage migration into adipose tissue in obese mice. Diabetes. 2012 Feb; 61(2):346-54. PMID: 22190646.
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      43. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky J, Sears DD, Caprio S, Shulman GI. SirT1 regulates adipose tissue inflammation. Diabetes. 2011 Dec; 60(12):3235-45. PMID: 22110092.
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      44. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky J. Adipocyte NCoR knockout decreases PPAR? phosphorylation and enhances PPAR? activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4):815-26. PMID: 22078880.
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      45. Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky J. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. PMID: 21985785.
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      46. Lee YS, Li P, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB. Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes. 2011 Oct; 60(10):2474-83. PMID: 21911747.
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      47. Ohtsubo K, Chen MZ, Olefsky J, Marth JD. Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat Med. 2011 Sep; 17(9):1067-75. PMID: 21841783.
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      48. Talukdar S, Olefsky J, Osborn O. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci. 2011 Sep; 32(9):543-50. PMID: 21663979.
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      49. Lan D, Lu M, Sharma S, Mellon PL, Olefsky J, Webster NJ. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHß gene expression by a SirT1-independent pathway in LßT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. PMID: 21679764.
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      50. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky J. Brain PPAR-? promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011 May; 17(5):618-22. PMID: 21532596.
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      51. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky J, Nagaki M, Moriwaki H, Brenner DA, Seishima M. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. PMID: 21163859.
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      52. Osborn O, Sears DD, Olefsky J. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 1; 12(6):553-4. PMID: 21109185.
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      53. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky J, Mellon PL, Webster NJ. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. PMID: 21076077.
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      54. Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky J. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010 Dec 15; 29(24):4223-36. PMID: 21045807.
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      55. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky J. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010 Sep 3; 142(5):687-98. PMID: 20813258.
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      56. Oh DY, Olefsky J. Medicine. Wnt fans the flames in obesity. Science. 2010 Jul 23; 329(5990):397-8. PMID: 20651140.
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      57. Lu M, Li P, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky J. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010 Jul; 24(7):1413-22. PMID: 20444886.
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      58. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky J, Brenner DA, Seki E. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. PMID: 20347818.
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      59. Li P, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky J. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010 May 14; 285(20):15333-45. PMID: 20308074.
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      60. Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky J. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May; 298(5):E1036-48. PMID: 20159859.
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      61. Wang T, Villegas S, Huang Y, White SK, Ahlem C, Lu M, Olefsky J, Reading C, Frincke JM, Alleva D, Flores-Riveros J. Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways. J Pharmacol Exp Ther. 2010 Apr; 333(1):70-80. PMID: 20068030.
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      62. Olefsky J, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010; 72:219-46. PMID: 20148674.
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      63. Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky J, Evans RM. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22504-9. PMID: 20018750.
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      64. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky J. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E419-28. PMID: 19996381.
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      65. Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky J. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009 Nov; 10(5):419-29. PMID: 19883619.
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      66. Patsouris D, Neels JG, Fan W, Li PP, Nguyen MT, Olefsky J. Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J Biol Chem. 2009 Nov 6; 284(45):31223-35. PMID: 19740750.
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      67. Olefsky J. IKKepsilon: a bridge between obesity and inflammation. Cell. 2009 Sep 4; 138(5):834-6. PMID: 19737512.
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      68. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky J. Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1137-46. PMID: 19706791.
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      69. Kim JJ, Li P, Huntley J, Chang JP, Arden KC, Olefsky J. FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes. 2009 Jun; 58(6):1275-82. PMID: 19289458.
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      70. Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky J, Perni RB. Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J Med Chem. 2009 Mar 12; 52(5):1275-83. PMID: 19199480.
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      71. Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky J. FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem. 2009 May 1; 284(18):12188-97. PMID: 19246449.
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      72. Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky J. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol. 2009 Mar; 29(5):1363-74. PMID: 19103747.
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      73. Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky J, Lee CH, Evans RM. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):20021-6. PMID: 19066220.
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      74. Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456(7219):269-73. PMID: 18849969.
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      75. Patsouris D, Li PP, Thapar D, Chapman J, Olefsky J, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008 Oct; 8(4):301-9. PMID: 18840360.
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      76. Olefsky J. Fat talks, liver and muscle listen. Cell. 2008 Sep 19; 134(6):914-6. PMID: 18805083.
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      77. Schenk S, Saberi M, Olefsky J. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep; 118(9):2992-3002. PMID: 18769626.
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      78. Sonoda N, Imamura T, Yoshizaki T, Babendure JL, Lu JC, Olefsky J. Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells. Proc Natl Acad Sci U S A. 2008 May 6; 105(18):6614-9. PMID: 18445652.
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      79. Féral CC, Neels JG, Kummer C, Slepak M, Olefsky J, Ginsberg MH. Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes. 2008 Jul; 57(7):1842-51. PMID: 18426864.
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      80. Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky J, Field SJ, Evans RM. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature. 2008 Feb 21; 451(7181):964-9. PMID: 18288188.
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      81. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky J, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6. PMID: 18046409.
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      82. de Luca C, Olefsky J. Inflammation and insulin resistance. FEBS Lett. 2008 Jan 9; 582(1):97-105. PMID: 18053812.
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      83. Lu M, Tang Q, Olefsky J, Mellon PL, Webster NJ. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. PMID: 18006641.
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      84. Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky J, Karin M. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97. PMID: 17983584.
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      85. Sears DD, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky J. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):515-21. PMID: 17963725.
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      86. Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky J. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007 Nov 30; 282(48):35279-92. PMID: 17916553.
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      87. Kawamata Y, Imamura T, Babendure JL, Lu JC, Yoshizaki T, Olefsky J. Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex. J Biol Chem. 2007 Sep 28; 282(39):28549-56. PMID: 17664271.
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      88. Hevener AL, Olefsky J, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. PMID: 17525798.
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      89. Yoshizaki T, Imamura T, Babendure JL, Lu JC, Sonoda N, Olefsky J. Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation. Mol Cell Biol. 2007 Jul; 27(14):5172-83. PMID: 17515613.
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      90. Liao W, Nguyen MT, Yoshizaki T, Favelyukis S, Patsouris D, Imamura T, Verma IM, Olefsky J. Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E219-27. PMID: 17389706.
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      91. Miles PD, Treuner K, Latronica M, Olefsky J, Barlow C. Impaired insulin secretion in a mouse model of ataxia telangiectasia. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E70-4. PMID: 17356010.
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      92. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky J. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr; 13(4):455-62. PMID: 17351624.
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      93. Hupfeld CJ, Olefsky J. Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol. 2007; 69:561-77. PMID: 17002595.
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      94. Olefsky J. The US's changing competitiveness in the biomedical sciences. J Clin Invest. 2007 Jan; 117(1):270-6. PMID: 17200723.
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      95. Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky J. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes. 2006 Aug; 55(8):2277-85. PMID: 16873691.
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      96. Hosch SE, Olefsky J, Kim JJ. APPLied mechanics: uncovering how adiponectin modulates insulin action. Cell Metab. 2006 Jul; 4(1):5-6. PMID: 16814726.
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      97. Neels JG, Olefsky J. Cell signaling. A new way to burn fat. Science. 2006 Jun 23; 312(5781):1756-8. PMID: 16794069.
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      98. Liao W, Nguyen MT, Imamura T, Singer O, Verma IM, Olefsky J. Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. Endocrinology. 2006 May; 147(5):2245-52. PMID: 16497797.
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      99. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky J, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. PMID: 16492734.
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      100. Neels JG, Olefsky J. Inflamed fat: what starts the fire? J Clin Invest. 2006 Jan; 116(1):33-5. PMID: 16395402.
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      101. de Luca C, Olefsky J. Stressed out about obesity and insulin resistance. Nat Med. 2006 Jan; 12(1):41-2; discussion 42. PMID: 16397561.
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      102. Huang J, Imamura T, Babendure JL, Lu JC, Olefsky J. Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem. 2005 Dec 23; 280(51):42300-6. PMID: 16239226.
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      103. Zhang J, Hupfeld CJ, Taylor SS, Olefsky J, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. PMID: 16177793.
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      104. Li LS, Babendure JL, Sinha SC, Olefsky J, Lerner RA. Synthesis and evaluation of photolabile insulin prodrugs. Bioorg Med Chem Lett. 2005 Sep 1; 15(17):3917-20. PMID: 15993597.
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      105. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky J. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005 Oct 21; 280(42):35361-71. PMID: 16085647.
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      106. Wilkes JJ, Nguyen MT, Bandyopadhyay GK, Nelson E, Olefsky J. Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1015-22. PMID: 16030065.
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      107. Hsiao A, Ideker T, Olefsky J, Subramaniam S. VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data. Nucleic Acids Res. 2005 Jul 1; 33(Web Server issue):W627-32. PMID: 15980550.
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      108. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky J. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Nov; 19(11):2760-8. PMID: 15994203.
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      109. Satoh H, Nguyen MT, Trujillo M, Imamura T, Usui I, Scherer PE, Olefsky J. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes. 2005 May; 54(5):1304-13. PMID: 15855314.
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      110. Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky J, Feng GS. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 May; 11(5):567-71. PMID: 15821749.
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      111. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. PMID: 15685170.
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      112. Wilkes JJ, Nelson E, Osborne M, Demarest KT, Olefsky J. Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E617-24. PMID: 15536205.
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      113. Hupfeld CJ, Resnik JL, Ugi S, Olefsky J. Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. J Biol Chem. 2005 Jan 14; 280(2):1016-23. PMID: 15520010.
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      114. Sharma PM, Son HS, Ugi S, Ricketts W, Olefsky J. Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Feb; 19(2):421-30. PMID: 15486046.
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      115. Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky J. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol. 2004 Oct; 24(19):8778-89. PMID: 15367694.
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      116. Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky J. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol. 2004 Oct; 24(20):8929-37. PMID: 15456867.
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      117. Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky J, Curtiss LK, Sims PJ. Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 7; 101(36):13296-301. PMID: 15328404.
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      118. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky J. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004 Jul 21; 23(14):2821-9. PMID: 15241473.
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      119. Satoh H, Nguyen MT, Miles PD, Imamura T, Usui I, Olefsky J. Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. J Clin Invest. 2004 Jul; 114(2):224-31. PMID: 15254589.
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      120. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. PMID: 15107844.
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      121. Yoshizaki T, Maegawa H, Egawa K, Ugi S, Nishio Y, Imamura T, Kobayashi T, Tamura S, Olefsky J, Kashiwagi A. Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem. 2004 May 21; 279(21):22715-26. PMID: 15016818.
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      122. Huang J, Hsia SH, Imamura T, Usui I, Olefsky J. Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes. Endocrinology. 2004 Apr; 145(4):1579-86. PMID: 14726447.
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      123. Pillay TS, Xiao S, Keranen L, Olefsky J. Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII. Cell Signal. 2004 Jan; 16(1):97-104. PMID: 14607280.
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      124. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky J, Buchanan TA, Scherer PE. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2004 Mar 26; 279(13):12152-62. PMID: 14699128.
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      125. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky J, Evans RM. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. PMID: 14660788.
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      126. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. PMID: 14625542.
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      127. Xie L, Lee SY, Andersen JN, Waters S, Shen K, Guo XL, Moller NP, Olefsky J, Lawrence DS, Zhang ZY. Cellular effects of small molecule PTP1B inhibitors on insulin signaling. Biochemistry. 2003 Nov 11; 42(44):12792-804. PMID: 14596593.
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      128. Wilkes JJ, Hevener A, Olefsky J. Chronic endothelin-1 treatment leads to insulin resistance in vivo. Diabetes. 2003 Aug; 52(8):1904-9. PMID: 12882904.
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      129. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky J. Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003 Jul; 23(14):4892-900. PMID: 12832475.
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      130. Lee B, Miles PD, Vargas L, Luan P, Glasco S, Kushnareva Y, Kornbrust ES, Grako KA, Wollheim CB, Maechler P, Olefsky J, Anderson CM. Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes. 2003 Apr; 52(4):965-73. PMID: 12663468.
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      131. Miles PD, Barak Y, Evans RM, Olefsky J. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar; 284(3):E618-26. PMID: 12556354.
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      132. Usui I, Imamura T, Huang J, Satoh H, Olefsky J. Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes. J Biol Chem. 2003 Apr 18; 278(16):13765-74. PMID: 12566459.
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      133. Kruszynska YT, Olefsky J, Frias JP. Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance. Metabolism. 2003 Feb; 52(2):233-8. PMID: 12601639.
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      134. Hupfeld CJ, Dalle S, Olefsky J. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 Jan 7; 100(1):161-6. PMID: 12509508.
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      135. Ruan H, Miles PD, Ladd CM, Ross K, Golub TR, Olefsky J, Lodish HF. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes. 2002 Nov; 51(11):3176-88. PMID: 12401708.
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      136. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky J. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes. 2002 Oct; 51(10):2968-74. PMID: 12351435.
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      137. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky J. Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol. 2002 Sep; 22(17):6272-85. PMID: 12167719.
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      138. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky J, Webster NJ. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. PMID: 12050161.
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      139. Hevener A, Reichart D, Janez A, Olefsky J. Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes. 2002 Jun; 51(6):1907-12. PMID: 12031980.
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      140. Ugi S, Imamura T, Ricketts W, Olefsky J. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol Cell Biol. 2002 Apr; 22(7):2375-87. PMID: 11884620.
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      141. Ugi S, Sharma PM, Ricketts W, Imamura T, Olefsky J. Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes. J Biol Chem. 2002 May 24; 277(21):18592-7. PMID: 11897789.
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      142. Liu F, Austin DA, Mellon PL, Olefsky J, Webster NJ. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. PMID: 11875099.
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      143. Worrall DS, Olefsky J. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. PMID: 11818508.
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      144. Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky J. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab. 2002 Jan; 87(1):226-34. PMID: 11788651.
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      145. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky J, Boland R, Evans RM. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1):303-8. PMID: 11756685.
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      146. Olefsky J. Nuclear receptor minireview series. J Biol Chem. 2001 Oct 5; 276(40):36863-4. PMID: 11459855.
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      147. Olefsky J. Prospects for research in diabetes mellitus. JAMA. 2001 Feb 7; 285(5):628-32. PMID: 11176871.
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      148. Janez A, Worrall DS, Olefsky J. Insulin-Mediated Cellular Insulin Resistance Decreases Osmotic Shock-Induced Glucose Transport in 3T3-L1 Adipocytes* *This work was supported by NIH Grant DK-33651 and the Veterans Administration Medical Research Service. Andrej Janez was supported by a grant from Slovenian Ministry of Science and Technology (sklad za mlade raziskovalce). Endocrinology. 2000 Dec 01; 141(12):4657-4663. PMID: 28201043.
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      149. Ishibashi KI, Imamura T, Sharma PM, Ugi S, Olefsky J. The Acute and Chronic Stimulatory Effects of Endothelin-1 on Glucose Transport Are Mediated by Distinct Pathways in 3T3-L1 Adipocytes* *This work was supported by NIH Grant DK-33651. Endocrinology. 2000 Dec 01; 141(12):4623-4628. PMID: 28201052.
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      150. Olefsky J. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest. 2000 Aug; 106(4):467-72. PMID: 10953021.
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      151. Clodi M, Vollenweider P, Klarlund J, Nakashima N, Martin S, Czech MP, Olefsky J. Effects of General Receptor for Phosphoinositides 1 on Insulin and Insulin-Like Growth Factor I-Induced Cytoskeletal Rearrangement, Glucose Transporter-4 Translocation, and Deoxyribonucleic Acid Synthesis* * This work was supported by Grants J 01287-Med and J 1584-Med from the Erwin Schro¨dinger Stipendium by the Fonds zur Fo¨rderung der wissenschaftlichen Forschung, Austria (to M.C.); a grant from the Schweizerische Stiftung fu¨r Medizinisch-Biologische Stipendien (to P.V.); and in part by NIH Grant DK-33651. Endocrinology. 1998 Dec 01; 139(12):4984-4990. PMID: 28204246.
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