Larissa Podust

Title(s)Emeritus Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseases
    NIH R21AI133394Jun 1, 2018 - May 31, 2021
    Role: Co-Principal Investigator
    Protein-Protein Interactions in Natural Product Biosynthesis
    NIH R01GM095970Mar 1, 2012 - Jan 31, 2024
    Role: Principal Investigator
    Structure-Aided Design of CYP51 Inhibitors for Treatment of Parasitic Infections
    NIH R01AI095437Jun 20, 2011 - May 31, 2017
    Role: Principal Investigator
    Structure and Engineering of Natural Product Cyctochrome P450 Enzymes
    NIH R01GM078553May 15, 2007 - Jan 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors. J Med Chem. 2023 Dec 28; 66(24):17059-17073. Sharma V, Madia VN, Tudino V, Nguyen JV, Debnath A, Messore A, Ialongo D, Patacchini E, Palenca I, Basili Franzin S, Seguella L, Esposito G, Petrucci R, Di Matteo P, Bortolami M, Saccoliti F, Di Santo R, Scipione L, Costi R, Podust LM. PMID: 38085955; PMCID: PMC10758121.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors. Future Med Chem. 2023 06; 15(11):959-985. Maltarollo VG, da Silva EB, Kronenberger T, Sena Andrade MM, de Lima Marques GV, Cândido Oliveira NJ, Santos LH, Oliveira Rezende Júnior C, Cassiano Martinho AC, Skinner D, Fajtová P, M Fernandes TH, Silveira Dos Santos ED, Rodrigues Gazolla PA, Martins de Souza AP, da Silva ML, Dos Santos FS, Lavorato SN, Oliveira Bretas AC, Carvalho DT, Franco LL, Luedtke S, Giardini MA, Poso A, Dias LC, Podust LM, Alves RJ, McKerrow J, Andrade SF, Teixeira RR, Siqueira-Neto JL, O'Donoghue A, de Oliveira RB, Ferreira RS. PMID: 37435731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition. ACS Chem Biol. 2022 10 21; 17(10):2890-2898. Corpuz JC, Patel A, Davis TD, Podust LM, McCammon JA, Burkart MD. PMID: 36173802; PMCID: PMC9808923.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2. J Chem Inf Model. 2022 12 26; 62(24):6553-6573. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. PMID: 35960688.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    5. Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51. Biochemistry. 2022 07 05; 61(13):1363-1377. Nienhaus K, Sharma V, Nienhaus GU, Podust LM. PMID: 35730528.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi. J Med Chem. 2022 03 10; 65(5):4255-4269. Barbosa Da Silva E, Sharma V, Hernandez-Alvarez L, Tang AH, Stoye A, O'Donoghue AJ, Gerwick WH, Payne RJ, McKerrow JH, Podust LM. PMID: 35188371.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    7. Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2. bioRxiv. 2022 Jan 05. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. PMID: 35018373; PMCID: PMC8750648.
      View in: PubMed   Mentions:
    8. Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway. ACS Catal. 2020 Nov 20; 10(22):13445-13454. Newmister SA, Srivastava KR, Espinoza RV, Haatveit KC, Khatri Y, Martini RM, Garcia-Borràs M, Podust LM, Houk KN, Sherman DH. PMID: 33569241; PMCID: PMC7869845.
      View in: PubMed   Mentions: 5  
    9. Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole. Mol Pharmacol. 2020 12; 98(6):770-780. Sharma V, Shing B, Hernandez-Alvarez L, Debnath A, Podust LM. PMID: 33008918; PMCID: PMC7674934.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri. ACS Chem Neurosci. 2020 10 07; 11(19):3089-3096. Hahn HJ, Abagyan R, Podust LM, Roy S, Ali IKM, Debnath A. PMID: 32881478; PMCID: PMC7544672.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    11. The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii. Antimicrob Agents Chemother. 2020 04 21; 64(5). Shing B, Singh S, Podust LM, McKerrow JH, Debnath A. PMID: 32094126; PMCID: PMC7179639.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    12. Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis. RSC Chem Biol. 2020 Apr 01; 1(1):8-12. Corpuz JC, Podust LM, Davis TD, Jaremko MJ, Burkart MD. PMID: 33305272; PMCID: PMC7723355.
      View in: PubMed   Mentions: 8  
    13. Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol Δ8-Δ7-Isomerase and Phenotypic Assays. ACS Infect Dis. 2019 12 13; 5(12):2029-2038. Shi D, Chahal KK, Oto P, Nothias LF, Debnath A, McKerrow JH, Podust LM, Abagyan R. PMID: 31583882; PMCID: PMC7085920.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450. J Biol Chem. 2019 11 01; 294(44):15947-15961. DeMars MD, Samora NL, Yang S, Garcia-Borràs M, Sanders JN, Houk KN, Podust LM, Sherman DH. PMID: 31488542; PMCID: PMC6827315.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    15. Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase. Arch Biochem Biophys. 2019 09 30; 673:108080. Davydov RM, Jennings G, Hoffman BM, Podust LM. PMID: 31445894; PMCID: PMC7575000.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents. J Med Chem. 2019 02 14; 62(3):1330-1347. Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista MR, Summa V, Costi R, Di Santo R. PMID: 30615444.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    17. Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. PLoS Pathog. 2018 09; 14(9):e1007245. Zhou W, Debnath A, Jennings G, Hahn HJ, Vanderloop BH, Chaudhuri M, Nes WD, Podust LM. PMID: 30212566; PMCID: PMC6136796.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    18. Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. Eur J Med Chem. 2018 Aug 05; 156:53-60. Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Costi R, Di Santo R. PMID: 30006174.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. PMID: 29284029; PMCID: PMC5746216.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    20. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2017 12; 11(12):e0006132. Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. PMID: 29281643; PMCID: PMC5744913.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    21. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. PMID: 28704396; PMCID: PMC5526615.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    22. Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG. Biochemistry. 2017 05 30; 56(21):2701-2714. Tietz DR, Podust LM, Sherman DH, Pochapsky TC. PMID: 28488849; PMCID: PMC5520640.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    23. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 02 17; 12(2):422-434. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. PMID: 27977118; PMCID: PMC5649375.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway. ACS Chem Biol. 2016 09 16; 11(9):2642-54. DeMars MD, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH. PMID: 27420774; PMCID: PMC5026600.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    25. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. PMID: 26876147; PMCID: PMC5003402.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    26. Correction: The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. PLoS Negl Trop Dis. 2016 Feb; 10(2):e0004439. Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL. PMID: 26828364; PMCID: PMC4734659.
      View in: PubMed   Mentions: 2     Fields:    
    27. The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004279. Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL. PMID: 26713732; PMCID: PMC4694641.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    28. Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations. Nat Chem. 2015 Aug; 7(8):653-60. Narayan AR, Jiménez-Osés G, Liu P, Negretti S, Zhao W, Gilbert MM, Ramabhadran RO, Yang YF, Furan LR, Li Z, Podust LM, Montgomery J, Houk KN, Sherman DH. PMID: 26201742; PMCID: PMC4518477.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    29. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003588. McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. PMID: 25768284; PMCID: PMC4359151.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    30. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11; 57(23):10162-75. Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. PMID: 25393646; PMCID: PMC4266343.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Drug strategies targeting CYP51 in neglected tropical diseases. Chem Rev. 2014 Nov 26; 114(22):11242-71. Choi JY, Podust LM, Roush WR. PMID: 25337991; PMCID: PMC4254036.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    32. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28; 57(16):6989-7005. Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. PMID: 25101801; PMCID: PMC4148169.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    33. Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives. Chembiochem. 2014 May 26; 15(8):1111-20. Vieira DF, Choi JY, Roush WR, Podust LM. PMID: 24771705; PMCID: PMC4091728.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    34. Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation. J Am Chem Soc. 2014 Apr 02; 136(13):4901-4. Negretti S, Narayan AR, Chiou KC, Kells PM, Stachowski JL, Hansen DA, Podust LM, Montgomery J, Sherman DH. PMID: 24627965; PMCID: PMC4012894.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    35. New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners. J Am Chem Soc. 2014 Mar 05; 136(9):3640-6. Zhang W, Liu Y, Yan J, Cao S, Bai F, Yang Y, Huang S, Yao L, Anzai Y, Kato F, Podust LM, Sherman DH, Li S. PMID: 24521145; PMCID: PMC3985502.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    36. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. ACS Med Chem Lett. 2014 Apr 10; 5(4):434-9. Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. PMID: 24900854; PMCID: PMC4027616.
      View in: PubMed   Mentions: 12  
    37. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. J Med Chem. 2013 Oct 10; 56(19):7651-68. Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. PMID: 24079662; PMCID: PMC3864028.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    38. A highly conserved mycobacterial cholesterol catabolic pathway. Environ Microbiol. 2013 Aug; 15(8):2342-59. García-Fernández E, Frank DJ, Galán B, Kells PM, Podust LM, García JL, Ortiz de Montellano PR. PMID: 23489718; PMCID: PMC3706556.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    39. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. PMID: 23400640; PMCID: PMC3566858.
      View in: PubMed   Mentions: 13  
    40. Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions. J Biol Chem. 2012 Nov 02; 287(45):37880-90. Li S, Tietz DR, Rutaganira FU, Kells PM, Anzai Y, Kato F, Pochapsky TC, Sherman DH, Podust LM. PMID: 22952225; PMCID: PMC3488060.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    41. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis. 2012; 6(7):e1736. Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. PMID: 22860142; PMCID: PMC3409115.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    42. Diversity of P450 enzymes in the biosynthesis of natural products. Nat Prod Rep. 2012 Oct; 29(10):1251-66. Podust LM, Sherman DH. PMID: 22820933; PMCID: PMC3454455.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    43. Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nat Chem. 2011 Jul 17; 3(8):628-33. Carlson JC, Li S, Gunatilleke SS, Anzai Y, Burr DA, Podust LM, Sherman DH. PMID: 21778983; PMCID: PMC3154026.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    44. Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):332-7. Ouellet H, Kells PM, Ortiz de Montellano PR, Podust LM. PMID: 21109436; PMCID: PMC3011832.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    45. Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate. Chem Biol. 2010 Aug 27; 17(8):841-51. Kells PM, Ouellet H, Santos-Aberturas J, Aparicio JF, Podust LM. PMID: 20797613; PMCID: PMC2932657.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    46. FMN binding site of yeast NADPH-cytochrome P450 reductase exposed at the surface is highly specific. ACS Chem Biol. 2010 Aug 20; 5(8):767-76. Ivanov AS, Gnedenko OV, Molnar AA, Archakov AI, Podust LM. PMID: 20557022; PMCID: PMC2924936.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    47. Structural control of cytochrome P450-catalyzed ω-hydroxylation. Arch Biochem Biophys. 2011 Mar 01; 507(1):86-94. Johnston JB, Ouellet H, Podust LM, Ortiz de Montellano PR. PMID: 20727847; PMCID: PMC2997901.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    48. Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. Mol Microbiol. 2010 Aug; 77(3):730-42. Ouellet H, Guan S, Johnston JB, Chow ED, Kells PM, Burlingame AL, Cox JS, Podust LM, de Montellano PR. PMID: 20545858; PMCID: PMC2909382.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    49. A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother. 2010 Jun; 54(6):2480-8. Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. PMID: 20385875; PMCID: PMC2876414.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    50. Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis. 2010 Apr 06; 4(4):e651. Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM. PMID: 20386598; PMCID: PMC2850312.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    51. Identification of small-molecule scaffolds for p450 inhibitors. Curr Protoc Microbiol. 2010 Feb; Chapter 17:Unit17.4. von Kries JP, Warrier T, Podust LM. PMID: 20131225; PMCID: PMC4487866.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    52. Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20687-92. Johnston JB, Kells PM, Podust LM, Ortiz de Montellano PR. PMID: 19933331; PMCID: PMC2791619.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    53. Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18463-8. Li S, Chaulagain MR, Knauff AR, Podust LM, Montgomery J, Sherman DH. PMID: 19833867; PMCID: PMC2774028.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    54. Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines. J Biol Chem. 2009 Sep 11; 284(37):25211-9. Podust LM, Ouellet H, von Kries JP, de Montellano PR. PMID: 19605350; PMCID: PMC2757224.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    55. Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz. 2009 Jul; 104 Suppl 1:263-9. McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. PMID: 19753483; PMCID: PMC4156466.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    56. Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trop Dis. 2009; 3(2):e372. Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. PMID: 19190730; PMCID: PMC2629123.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    57. Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae. J Biol Chem. 2009 Feb 27; 284(9):5723-30. Li S, Ouellet H, Sherman DH, Podust LM. PMID: 19124459; PMCID: PMC2931524.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    58. 2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis. Biochemistry. 2008 Nov 25; 47(47):12523-31. Podust LM, Ioanoviciu A, Ortiz de Montellano PR. PMID: 18980385; PMCID: PMC2645934.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    59. X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51). J Biol Chem. 2008 May 30; 283(22):15152-9. Eddine AN, von Kries JP, Podust MV, Warrier T, Kaufmann SH, Podust LM. PMID: 18367444; PMCID: PMC2397474.
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    60. Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs. J Biol Chem. 2008 Feb 22; 283(8):5069-80. Ouellet H, Podust LM, de Montellano PR. PMID: 18089574; PMCID: PMC2958778.
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    61. Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. J Am Chem Soc. 2007 Oct 31; 129(43):12940-1. Li S, Podust LM, Sherman DH. PMID: 17915876; PMCID: PMC2572779.
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    62. Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. Antimicrob Agents Chemother. 2007 Nov; 51(11):3915-23. Podust LM, von Kries JP, Eddine AN, Kim Y, Yermalitskaya LV, Kuehne R, Ouellet H, Warrier T, Alteköster M, Lee JS, Rademann J, Oschkinat H, Kaufmann SH, Waterman MR. PMID: 17846131; PMCID: PMC2151439.
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    63. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. J Biol Chem. 2006 Sep 08; 281(36):26289-97. Sherman DH, Li S, Yermalitskaya LV, Kim Y, Smith JA, Waterman MR, Podust LM. PMID: 16825192; PMCID: PMC2939096.
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    64. Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2). Biochemistry. 2006 Jun 20; 45(24):7493-500. Zhao B, Waterman MR, Isin EM, Sundaramoorthy M, Podust LM. PMID: 16768445.
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    65. A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases. Structure. 2006 Jan; 14(1):51-61. Lamb DC, Kim Y, Yermalitskaya LV, Yermalitsky VN, Lepesheva GI, Kelly SL, Waterman MR, Podust LM. PMID: 16407065.
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    66. Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis. J Biol Chem. 2005 Dec 09; 280(49):41090-100. Wu ZL, Podust LM, Guengerich FP. PMID: 16215230.
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    67. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem. 2005 Mar 25; 280(12):11599-607. Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. PMID: 15659395.
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    68. Estriol bound and ligand-free structures of sterol 14alpha-demethylase. Structure. 2004 Nov; 12(11):1937-45. Podust LM, Yermalitskaya LV, Lepesheva GI, Podust VN, Dalmasso EA, Waterman MR. PMID: 15530358.
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    69. Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways. Protein Sci. 2004 Jan; 13(1):255-68. Podust LM, Bach H, Kim Y, Lamb DC, Arase M, Sherman DH, Kelly SL, Waterman MR. PMID: 14691240; PMCID: PMC2286509.
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    70. Identification of amino acids in rat pregnane X receptor that determine species-specific activation. Mol Pharmacol. 2004 Jan; 65(1):36-44. Tirona RG, Leake BF, Podust LM, Kim RB. PMID: 14722235.
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    71. The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems. J Biol Chem. 2003 Apr 04; 278(14):12214-21. Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. PMID: 12519772.
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    72. Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family. Biochem J. 2002 Jun 01; 364(Pt 2):555-62. Lamb DC, Fowler K, Kieser T, Manning N, Podust LM, Waterman MR, Kelly DE, Kelly SL. PMID: 12023899; PMCID: PMC1222601.
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    73. The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). J Biol Chem. 2002 Jul 05; 277(27):24000-5. Lamb DC, Skaug T, Song HL, Jackson CJ, Podust LM, Waterman MR, Kell DB, Kelly DE, Kelly SL. PMID: 11943767.
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    74. Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51. J Inorg Biochem. 2001 Dec 15; 87(4):227-35. Podust LM, Stojan J, Poulos TL, Waterman MR. PMID: 11744060.
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    75. Folding requirements are different between sterol 14alpha-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs. J Biol Chem. 2001 Jul 27; 276(30):28413-20. Lepesheva GI, Podust LM, Bellamine A, Waterman MR. PMID: 11373285.
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    76. Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3068-73. Podust LM, Poulos TL, Waterman MR. PMID: 11248033; PMCID: PMC30608.
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    77. Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. J Biol Chem. 2001 Jan 05; 276(1):505-13. Podust LM, Krezel AM, Kim Y. PMID: 11018027.
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    78. Tyrosine 114 is essential for the trimeric structure and the functional activities of human proliferating cell nuclear antigen. EMBO J. 1995 Nov 15; 14(22):5745-51. Jónsson ZO, Podust VN, Podust LM, Hübscher U. PMID: 8521831; PMCID: PMC394689.
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    79. Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21. Biochemistry. 1995 Jul 11; 34(27):8869-75. Podust VN, Podust LM, Goubin F, Ducommun B, Hübscher U. PMID: 7612628.
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    80. Mammalian DNA polymerase auxiliary proteins: analysis of replication factor C-catalyzed proliferating cell nuclear antigen loading onto circular double-stranded DNA. Mol Cell Biol. 1995 Jun; 15(6):3072-81. Podust LM, Podust VN, Sogo JM, Hübscher U. PMID: 7760803; PMCID: PMC230538.
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    81. DNA polymerase delta holoenzyme: action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases. Biochemistry. 1995 Apr 18; 34(15):5003-10. Podust VN, Podust LM, Müller F, Hübscher U. PMID: 7711022.
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    82. Assembly of DNA polymerase delta and epsilon holoenzymes depends on the geometry of the DNA template. Nucleic Acids Res. 1994 Aug 11; 22(15):2970-5. Podust LM, Podust VN, Floth C, Hübscher U. PMID: 7915029; PMCID: PMC310263.
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    83. [Structure of a single-stranded DNA target as a factor influencing the effectiveness of its modification with a complementary reagent]. Bioorg Khim. 1992 Dec; 18(12):1496-504. Fedorova OS, Podust LM, Gorn VV, Maksakova GA. PMID: 1301002.
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    84. The influence of the target structure on the efficiency of alkylation of single-stranded DNA with the reactive derivatives of antisense oligonucleotides. FEBS Lett. 1992 May 04; 302(1):47-50. Fedorova OS, Podust LM, Maksakova GA, Gorn VV, Knorre DG. PMID: 1587352.
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    85. [Sequence specificity modification of double-stranded DNA with an alkylating derivative of oligodeoxyribonucleotide pT(CT)6]. Bioorg Khim. 1989 Mar; 15(3):363-9. Podust LM, Gaìdamakov SA, Abramova TV, Vlasov VV, Gorn VV. PMID: 2742616.
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    86. Sequence-specific chemical modification of double-stranded DNA with alkylating oligodeoxyribonucleotide derivatives. Gene. 1988 Dec 10; 72(1-2):313-22. Vlassov VV, Gaidamakov SA, Zarytova VF, Knorre DG, Levina AS, Nikonova AA, Podust LM, Fedorova OS. PMID: 3149602.
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    87. Application of tris(2,2'-bipyridyl)ruthenium(III) for the investigation of DNA spatial structure by a chemical modification method. J Inorg Biochem. 1988 Nov; 34(3):149-55. Fedorova OS, Podust LM. PMID: 3236000.
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    88. Complementary addressed modification of double-stranded DNA within a ternary complex. FEBS Lett. 1988 Feb 15; 228(2):273-6. Fedorova OS, Knorre DG, Podust LM, Zarytova VF. PMID: 3342881.
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    89. [Complementary-addressed modification of double-stranded DNA in a triple-strand complex]. Dokl Akad Nauk SSSR. 1988; 300(4):1006-9. Knorre DG, Zarytova VF, Podust LM, Fedorova OS. PMID: 3168743.
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    90. [Effectiveness of the modification of a single-stranded DNA fragment by alkylating derivatives of oligonucleotides]. Bioorg Khim. 1987 Sep; 13(9):1221-9. Vlasov VV, Knorre DG, Kutiavin IV, Mamaev SV, Podust LM. PMID: 3426641.
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    91. [Affinity modification of Escherichia coli ribosomes with photoactivated analogs of mRNA]. Mol Biol (Mosk). 1984 Jul-Aug; 18(4):907-18. Gimautdinova OI, Zenkova MA, Karpova GG, Podust LM. PMID: 6209544.
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