Michael Kelner

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Halogenated Alkenes and Microsomal GSH-transferases
    NIH R01ES013687Aug 8, 2006 - Apr 30, 2012
    Role: Principal Investigator
    ALTERATION OF ERCC GENE EXPRESSION IN VITRO AND IN VIVO
    NIH R01AG013153Aug 1, 1996 - Jul 31, 2000
    Role: Principal Investigator
    Coordinated Regulation of Antioxidant Enzymes
    NIH R01CA052310Apr 1, 1992 - Jun 30, 2006
    Role: Principal Investigator
    GENETIC INSIGHT INTO OXIDATIVE DAMAGE
    NIH R01AG010746Jan 15, 1992 - Dec 31, 1995
    Role: Principal Investigator
    GPX1 ENZYME REGULATION BY OXIDATIVE XENOBIOTICS
    NIH R01ES004989Jul 1, 1990 - Nov 30, 2004
    Role: Principal Investigator
    INHIBITION OF PARAQUAT OXYGEN-MEDIATED TOXICITY
    NIH K08ES000142Jul 1, 1985 - Jan 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 Serology Status Detected by Commercialized Platforms Distinguishes Previous Infection and Vaccination Adaptive Immune Responses. J Appl Lab Med. 2021 Jun 25. Suhandynata RT, Bevins NJ, Tran JT, Huang D, Hoffman MA, Lund K, Kelner MJ, McLawhon RW, Gonias SL, Nemazee D, Fitzgerald RL. PMID: 34170314.
      View in: PubMed   Mentions:    Fields:    
    2. SARS-CoV-2 Serology Status Detected by Commercialized Platforms Distinguishes Previous Infection and Vaccination Adaptive Immune Responses. medRxiv. 2021 Mar 12. Suhandynata RT, Bevins NJ, Tran JT, Huang D, Hoffman MA, Lund K, Kelner MJ, McLawhon RW, Gonias SL, Nemazee D, Fitzgerald RL. PMID: 33758902.
      View in: PubMed   Mentions:
    3. Commercial Serology Assays Predict Neutralization Activity against SARS-CoV-2. Clin Chem. 2021 01 30; 67(2):404-414. Suhandynata RT, Hoffman MA, Huang D, Tran JT, Kelner MJ, Reed SL, McLawhon RW, Voss JE, Nemazee D, Fitzgerald RL. PMID: 33084854.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    4. Multi-Platform Comparison of SARS-CoV-2 Serology Assays for the Detection of COVID-19. J Appl Lab Med. 2020 11 01; 5(6):1324-1336. Suhandynata RT, Hoffman MA, Kelner MJ, McLawhon RW, Reed SL, Fitzgerald RL. PMID: 32766840.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsPHPublic Health
    5. Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19. J Appl Lab Med. 2020 09 01; 5(5):908-920. Suhandynata RT, Hoffman MA, Kelner MJ, McLawhon RW, Reed SL, Fitzgerald RL. PMID: 32428207.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCellsPHPublic Health
    6. A Dilution Method to Mitigate Biotin Interference in Cardiac Troponin T Testing. J Appl Lab Med. 2019 11; 4(3):415-421. Bevins NJ, Hubbard JA, Fitzgerald RL, Kelner MJ. PMID: 31659079.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biol. 2018 07; 17:171-179. Bräutigam L, Zhang J, Dreij K, Spahiu L, Holmgren A, Abe H, Tew KD, Townsend DM, Kelner MJ, Morgenstern R, Johansson K. PMID: 29702404.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. Hydroxyurea derivatives of irofulven with improved antitumor efficacy. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1836-8. Staake MD, Kashinatham A, McMorris TC, Estes LA, Kelner MJ. PMID: 26922141.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue. Free Radic Biol Med. 2014 Apr; 69:167-71. Kelner MJ, Diccianni MB, Yu AL, Rutherford MR, Estes LA, Morgenstern R. PMID: 24486338.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. A rare and unique case of aggressive IgE-? plasma cell myeloma in a 28-year-old woman presented initially as an orbital mass. Hum Pathol. 2012 Dec; 43(12):2376-84. Li K, Ku G, Yan M, Broome HE, Kelner M, Wang HY. PMID: 23084304.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene. J Med Chem. 2010 Feb 11; 53(3):1109-16. McMorris TC, Chimmani R, Alisala K, Staake MD, Banda G, Kelner MJ. PMID: 20067264.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Stability of levothyroxine sodium 0.4 microg/mL in 0.9% sodium chloride injection. Prog Transplant. 2009 Dec; 19(4):354-6; quiz 357. Stadalman KA, Kelner MJ, Box K, Dominguez A, Rigby JF. PMID: 20050459.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Preparation of crotaline F-ab antivenom (CroFab) with automated mixing methods: in vitro observations. Clin Toxicol (Phila). 2009 Jan; 47(1):69-71. Vohra R, Kelner M, Clark RF. PMID: 19153853.
      View in: PubMed   Mentions:    Fields:    
    14. CroFab reconstitution in various media: an in vitro solubility study. Clin Toxicol (Phila). 2008 Nov; 46(9):808-10. Vohra R, Clark R, Kelner M. PMID: 18821147.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec; 63(1):19-26. Kelner MJ, McMorris TC, Rojas RJ, Estes LA, Suthipinijtham P. PMID: 18305940.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    16. Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil. Invest New Drugs. 2008 Oct; 26(5):407-15. Kelner MJ, McMorris TC, Rojas RJ, Estes LA, Suthipinijtham P. PMID: 18227973.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11. Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. PMID: 18180294.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    18. Synthesis and antitumor activity of amine analogs of irofulven. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6770-2. McMorris TC, Chimmani R, Gurram M, Staake MD, Kelner MJ. PMID: 17977722.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Phase I/II study of continuous-infusion troxacitabine in refractory acute myeloid leukemia. J Clin Oncol. 2007 Jan 01; 25(1):10-5. Roboz GJ, Giles FJ, Ritchie EK, Allen-Bard S, Curcio TJ, Wilkes MA, Park SL, Kantarjian HM, Faderl S, Ravandi F, Kelner MJ, Feldman EJ. PMID: 17146106.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    20. Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression. Biochim Biophys Acta. 2004 May 25; 1678(2-3):163-9. Kelner MJ, Bagnell RD, Morgenstern R. PMID: 15157743.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Synthesis and biological activity of enantiomers of antitumor irofulven. J Org Chem. 2004 Feb 06; 69(3):619-23. McMorris TC, Staake MD, Kelner MJ. PMID: 14750783.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring. J Org Chem. 2003 Dec 12; 68(25):9648-53. McMorris TC, Cong Q, Kelner MJ. PMID: 14656090.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3. Biochim Biophys Acta. 2003 Jun 19; 1627(2-3):79-84. Ekström L, Lyrenäs L, Jakobsson PJ, Morgenstern R, Kelner MJ. PMID: 12818425.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Reaction of irofulven with zinc and acid. J Nat Prod. 2003 Feb; 66(2):310-2. McMorris TC, Moon SS, Kelner MJ. PMID: 12608875.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    25. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst). 2002 Dec 05; 1(12):1027-38. Jaspers NG, Raams A, Kelner MJ, Ng JM, Yamashita YM, Takeda S, McMorris TC, Hoeijmakers JH. PMID: 12531012.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    26. Sesquiterpenes from Omphalotus illudens. Phytochemistry. 2002 Oct; 61(4):395-8. McMorris TC, Kashinatham A, Lira R, Rundgren H, Gantzel PK, Kelner MJ, Dawe R. PMID: 12377232.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    27. Enhanced antitumor activity of irofulven in combination with antimitotic agents. Invest New Drugs. 2002 Aug; 20(3):271-9. Kelner MJ, McMorris TC, Rojas RJ, Trani NA, Velasco TR, Estes LA, Suthipinijtham P. PMID: 12201490.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    28. Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C. Cancer Chemother Pharmacol. 2002 May; 49(5):412-8. Kelner MJ, McMorris TC, Rojas RJ, Trani NA, Estes L. PMID: 11976836.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    29. Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents. Gene. 2000 May 02; 248(1-2):109-16. Kelner MJ, Bagnell RD, Montoya MA, Lanham KA. PMID: 10806356.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    30. Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. J Biol Chem. 2000 Apr 28; 275(17):13000-6. Kelner MJ, Bagnell RD, Montoya MA, Estes LA, Forsberg L, Morgenstern R. PMID: 10777602.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    31. Structural organization of the human glutathione reductase gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence. Biochem Biophys Res Commun. 2000 Mar 16; 269(2):366-8. Kelner MJ, Montoya MA. PMID: 10708558.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    32. Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft. Anticancer Drugs. 2000 Mar; 11(3):217-24. Kelner MJ, McMorris TC, Estes LA, Oval MY, Rojas RJ, Lynn JR, Lanham KA, Samson KM. PMID: 10831281.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Characterization of MGI 114 (HMAF) histiospecific toxicity in human tumor cell lines. Cancer Chemother Pharmacol. 1999; 44(3):235-40. Kelner MJ, McMorris TC, Montoya MA, Estes L, Uglik SF, Rutherford M, Samson KM, Bagnell RD, Taetle R. PMID: 10453725.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    34. Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3. Biochem Biophys Res Commun. 1998 Aug 10; 249(1):53-5. Kelner MJ, Montoya MA. PMID: 9705830.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Characterization of acylfulvene histiospecific toxicity in human tumor cell lines. Cancer Chemother Pharmacol. 1998; 41(3):237-42. Kelner MJ, McMorris TC, Montoya MA, Estes L, Uglik SF, Rutherford M, Samson KM, Bagnell RD, Taetle R. PMID: 9443641.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. Design and Synthesis of Antitumor Acylfulvenes. J Org Chem. 1997 May 02; 62(9):3015-3018. McMorris TC, Yu J, Hu Y, Estes LA, Kelner MJ. PMID: 11671671.
      View in: PubMed   Mentions: 1     Fields:    
    37. Heterologous expression of carbonyl reductase: demonstration of prostaglandin 9-ketoreductase activity and paraquat resistance. Life Sci. 1997; 61(23):2317-22. Kelner MJ, Estes L, Rutherford M, Uglik SF, Peitzke JA. PMID: 9408054.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells