Partho Ghosh

Title(s)Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Evasion of host immunity by the M protein
    NIH R01AI154149Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Selective infidelity in diversity-generating retroelements
    NIH R01GM132720Dec 1, 2019 - Nov 30, 2023
    Role: Principal Investigator
    How group A Streptococcus M1 protein resists cathelicidins
    NIH R21AI144901Mar 1, 2019 - Feb 28, 2021
    Role: Principal Investigator
    Broad recognition of group A Streptococcus M proteins
    NIH R21AI140436May 18, 2018 - Apr 30, 2020
    Role: Principal Investigator
    X-ray generator and associated optics for macromolecular crystallography at UCSD
    NIH S10OD011957Apr 1, 2012 - Mar 31, 2013
    Role: Principal Investigator
    Diversity-Generation and Variable Protein Displays in Pathogens and Phage
    NIH R01AI096838Feb 15, 2012 - Jan 31, 2018
    Role: Principal Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH R56AI096837Jul 1, 2011 - Jul 31, 2019
    Role: Principal Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH R01AI096837Jul 1, 2011 - Jun 30, 2017
    Role: Principal Investigator
    High-throughput, nanoliter-scale macromolecular crystallization at UCSD
    NIH S10RR026795Apr 1, 2011 - Mar 31, 2012
    Role: Principal Investigator
    Variable Proteins of Diversity-generating Retroelements
    NIH R01AI072504Sep 15, 2007 - Aug 31, 2011
    Role: Principal Investigator
    Streptococcus M protein and antibody cross-reactivity in rheumatic fever
    NIH R21AI071167Jul 1, 2007 - Jun 30, 2009
    Role: Principal Investigator
    Protein Translocation by the Type III Secretion System
    NIH R01AI061452May 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Host activation of the Pseudomonas aeruginosa cytoxin ExoU
    NIH R21AI069342Apr 1, 2006 - Mar 31, 2008
    Role: Principal Investigator
    Structure of the multidrug efflux protein AcrA
    NIH R03AI064312Mar 1, 2005 - Feb 28, 2007
    Role: Principal Investigator
    Mechanism of Host Cell Invasion by Microbial Pathogens
    NIH R01AI047163May 1, 2000 - Dec 31, 2010
    Role: Principal Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A conserved 3D pattern in a Streptococcus pyogenes M protein immunogen elicits M-type crossreactivity. J Biol Chem. 2023 08; 299(8):104980. Wang KC, Kuliyev E, Nizet V, Ghosh P. PMID: 37390991; PMCID: PMC10400905.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Strengthening of enterococcal biofilms by Esp. PLoS Pathog. 2022 09; 18(9):e1010829. Spiegelman L, Bahn-Suh A, Montaño ET, Zhang L, Hura GL, Patras KA, Kumar A, Tezcan FA, Nizet V, Tsutakawa SE, Ghosh P. PMID: 36103556; PMCID: PMC9512215.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37. Elife. 2022 06 21; 11. Kolesinski P, Wang KC, Hirose Y, Nizet V, Ghosh P. PMID: 35726694; PMCID: PMC9212996.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Contribution of Streptococcus pyogenes M87 protein to innate immune resistance and virulence. Microb Pathog. 2022 Aug; 169:105636. Hirose Y, Kolesinski P, Hiraoka M, Uchiyama S, Zurich RH, Kumaraswamy M, Bjanes E, Ghosh P, Kawabata S, Nizet V. PMID: 35724830.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Crystal structure of a Thermus aquaticus diversity-generating retroelement variable protein. PLoS One. 2019; 14(1):e0205618. Handa S, Shaw KL, Ghosh P. PMID: 30629599; PMCID: PMC6328139.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    6. Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex. Nucleic Acids Res. 2018 10 12; 46(18):9711-9725. Handa S, Jiang Y, Tao S, Foreman R, Schinazi RF, Miller JF, Ghosh P. PMID: 30007279; PMCID: PMC6182149.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    7. Variation, Indispensability, and Masking in the M protein. Trends Microbiol. 2018 02; 26(2):132-144. Ghosh P. PMID: 28867148; PMCID: PMC5794653.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    8. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol. 2017 Oct; 2(10):1425-1434. Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. PMID: 28784982; PMCID: PMC5750061.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    9. Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones. Sci Rep. 2017 02 21; 7:43039. Döhrmann S, LaRock CN, Anderson EL, Cole JN, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. PMID: 28220899; PMCID: PMC5318940.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    10. Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol. 2016 Sep 05; 1(11):16155. Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P. PMID: 27595425; PMCID: PMC5014329.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    11. Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements. BMC Struct Biol. 2016 08 31; 16(1):13. Handa S, Paul BG, Miller JF, Valentine DL, Ghosh P. PMID: 27578274; PMCID: PMC5006420.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    12. Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9515-20. Stewart CM, Buffalo CZ, Valderrama JA, Henningham A, Cole JN, Nizet V, Ghosh P. PMID: 27512043; PMCID: PMC5003295.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    13. Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing. Cell Host Microbe. 2015 Oct 14; 18(4):471-7. LaRock CN, Döhrmann S, Todd J, Corriden R, Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet V. PMID: 26468750; PMCID: PMC4636435.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    14. Structure of the essential Plasmodium host cell traversal protein SPECT1. PLoS One. 2014; 9(12):e114685. Hamaoka BY, Ghosh P. PMID: 25479287; PMCID: PMC4257719.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J Biol Chem. 2014 Nov 14; 289(46):32303-32315. Henningham A, Yamaguchi M, Aziz RK, Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J, Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV, Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole JN. PMID: 25266727; PMCID: PMC4231703.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. Functionally essential interaction between Yersinia YscO and the T3S4 domain of YscP. J Bacteriol. 2013 Oct; 195(20):4631-8. Mukerjea R, Ghosh P. PMID: 23935040; PMCID: PMC3807450.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    17. Structure of the essential diversity-generating retroelement protein bAvd and its functionally important interaction with reverse transcriptase. Structure. 2013 Feb 05; 21(2):266-76. Alayyoubi M, Guo H, Dey S, Golnazarian T, Brooks GA, Rong A, Miller JF, Ghosh P. PMID: 23273427; PMCID: PMC3570691.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    18. Structure and glycolipid binding properties of the nematicidal protein Cry5B. Biochemistry. 2012 Dec 11; 51(49):9911-21. Hui F, Scheib U, Hu Y, Sommer RJ, Aroian RV, Ghosh P. PMID: 23150986; PMCID: PMC3567309.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    19. Structure and interactions of the cytoplasmic domain of the Yersinia type III secretion protein YscD. J Bacteriol. 2012 Nov; 194(21):5949-58. Gamez A, Mukerjea R, Alayyoubi M, Ghassemian M, Ghosh P. PMID: 22942247; PMCID: PMC3486071.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    20. Two translation products of Yersinia yscQ assemble to form a complex essential to type III secretion. Biochemistry. 2012 Feb 28; 51(8):1669-77. Bzymek KP, Hamaoka BY, Ghosh P. PMID: 22320351; PMCID: PMC3289748.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    21. Conservation of the C-type lectin fold for massive sequence variation in a Treponema diversity-generating retroelement. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14649-53. Le Coq J, Ghosh P. PMID: 21873231; PMCID: PMC3167528.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    22. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature. 2011 Apr 07; 472(7341):64-8. Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P. PMID: 21475196; PMCID: PMC3268815.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    23. Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog. 2011 Mar; 7(3):e1001314. Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV. PMID: 21408619; PMCID: PMC3048360.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    24. The nonideal coiled coil of M protein and its multifarious functions in pathogenesis. Adv Exp Med Biol. 2011; 715:197-211. Ghosh P. PMID: 21557065; PMCID: PMC5541941.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    25. A solvent-exposed patch in chaperone-bound YopE is required for translocation by the type III secretion system. J Bacteriol. 2010 Jun; 192(12):3114-22. Rodgers L, Mukerjea R, Birtalan S, Friedberg D, Ghosh P. PMID: 20382763; PMCID: PMC2901707.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex. PLoS One. 2009 Dec 18; 4(12):e8364. Singh RK, Lau D, Noviello CM, Ghosh P, Guatelli JC. PMID: 20020046; PMCID: PMC2791223.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    27. M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun. 2009; 1(3):202-14. Lauth X, von Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V. PMID: 20375578; PMCID: PMC3241932.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    28. Selective ligand recognition by a diversity-generating retroelement variable protein. PLoS Biol. 2008 Jun 03; 6(6):e131. Miller JL, Le Coq J, Hodes A, Barbalat R, Miller JF, Ghosh P. PMID: 18532877; PMCID: PMC2408619.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    29. The type III secretion chaperone SycE promotes a localized disorder-to-order transition in the natively unfolded effector YopE. J Biol Chem. 2008 Jul 25; 283(30):20857-63. Rodgers L, Gamez A, Riek R, Ghosh P. PMID: 18502763; PMCID: PMC2475703.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    30. Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence. Science. 2008 Mar 07; 319(5868):1405-8. McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P. PMID: 18323455; PMCID: PMC2288698.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    31. Conformational flexibility in the multidrug efflux system protein AcrA. Structure. 2006 Mar; 14(3):577-87. Mikolosko J, Bobyk K, Zgurskaya HI, Ghosh P. PMID: 16531241; PMCID: PMC1997295.
      View in: PubMed   Mentions: 137     Fields:    Translation:Cells
    32. Identification of a bacterial type III effector family with G protein mimicry functions. Cell. 2006 Jan 13; 124(1):133-45. Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE. PMID: 16413487.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    33. Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):927-32. Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE. PMID: 16410353; PMCID: PMC1347996.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    34. The C-type lectin fold as an evolutionary solution for massive sequence variation. Nat Struct Mol Biol. 2005 Oct; 12(10):886-92. McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P. PMID: 16170324.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    35. Process of protein transport by the type III secretion system. Microbiol Mol Biol Rev. 2004 Dec; 68(4):771-95. Ghosh P. PMID: 15590783; PMCID: PMC539011.
      View in: PubMed   Mentions: 175     Fields:    Translation:Cells
    36. Characterization of the calcium-binding sites of Listeria monocytogenes InlB. Biochem Biophys Res Commun. 2004 Apr 02; 316(2):379-86. Marino M, Banerjee M, Copp J, Dramsi S, Chapman T, van der Geer P, Cossart P, Ghosh P. PMID: 15020228.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    37. GW domains of the Listeria monocytogenes invasion protein InlB are required for potentiation of Met activation. Mol Microbiol. 2004 Apr; 52(1):257-71. Banerjee M, Copp J, Vuga D, Marino M, Chapman T, van der Geer P, Ghosh P. PMID: 15049825.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    38. Structural elements required for deamidation of RhoA by cytotoxic necrotizing factor 1. Biochemistry. 2003 Nov 11; 42(44):12784-91. Buetow L, Ghosh P. PMID: 14596592.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    39. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J Biol Chem. 2003 Oct 17; 278(42):41326-32. Phillips RM, Six DA, Dennis EA, Ghosh P. PMID: 12915403.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    40. Novel therapeutic strategies based on toll-like receptor signaling. Curr Opin Chem Biol. 2003 Aug; 7(4):446-51. Lawton JA, Ghosh P. PMID: 12941417.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    41. Multiple regions of internalin B contribute to its ability to turn on the Ras-mitogen-activated protein kinase pathway. J Biol Chem. 2003 Mar 07; 278(10):7783-9. Copp J, Marino M, Banerjee M, Ghosh P, van der Geer P. PMID: 12488439.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    42. The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. J Biol Chem. 2002 Jul 12; 277(28):25791-7. Que X, Ngo H, Lawton J, Gray M, Liu Q, Engel J, Brinen L, Ghosh P, Joiner KA, Reed SL. PMID: 12000756.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    43. Strategies for the structural determination of the catalytic domain of Escherichia coli cytotoxic necrotizing factor 1. Acta Crystallogr D Biol Crystallogr. 2002 Feb; 58(Pt 2):366-9. Buetow L, Flatau G, Chiu K, Boquet P, Ghosh P. PMID: 11807279.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    Partho's Networks
    Concepts (247)
    Derived automatically from this person's publications.
    Co-Authors (22)
    People in Profiles who have published with this person.
    Similar People (60)
    People who share similar concepts with this person.
    Same Department
    Search Department