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Partho Ghosh

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0375
La Jolla CA 92093
Phone858-822-1139
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    Collapse Research 
    Collapse Research Activities and Funding
    X-ray generator and associated optics for macromolecular crystallography at UCSD
    NIH S10OD011957Apr 1, 2012 - Mar 31, 2013
    Role: Principal Investigator
    Diversity-Generation and Variable Protein Displays in Pathogens and Phage
    NIH/NIAID R01AI096838Feb 15, 2012 - Jan 31, 2017
    Role: Principal Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH/NIAID R01AI096837Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    High-throughput, nanoliter-scale macromolecular crystallization at UCSD
    NIH/NCRR S10RR026795Apr 1, 2011 - Mar 31, 2012
    Role: Principal Investigator
    Variable Proteins of Diversity-generating Retroelements
    NIH/NIAID R01AI072504Sep 15, 2007 - Aug 31, 2011
    Role: Principal Investigator
    Streptococcus M protein and antibody cross-reactivity in rheumatic fever
    NIH/NIAID R21AI071167Jul 1, 2007 - Jun 30, 2009
    Role: Principal Investigator
    Protein Translocation by the Type III Secretion System
    NIH/NIAID R01AI061452May 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Host activation of the Pseudomonas aeruginosa cytoxin ExoU
    NIH/NIAID R21AI069342Apr 1, 2006 - Mar 31, 2008
    Role: Principal Investigator
    Structure of the multidrug efflux protein AcrA
    NIH/NIAID R03AI064312Mar 1, 2005 - Feb 28, 2007
    Role: Principal Investigator
    Mechanism of Host Cell Invasion by Microbial Pathogens
    NIH/NIAID R01AI047163May 1, 2000 - Dec 31, 2010
    Role: Principal Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wu L, Gingery M, Abebe M, Arambula D, Czornyj E, Handa S, Khan H, Liu M, Pohlschroder M, Shaw KL, Du A, Guo H, Ghosh P, Miller JF, Zimmerly S. Diversity-generating retroelements: natural variation, classification and evolution inferred from a large-scale genomic survey. Nucleic Acids Res. 2018 Jan 09; 46(1):11-24. PMID: 29186518.
      View in: PubMed
    2. Ghosh P. Variation, Indispensability, and Masking in the M protein. Trends Microbiol. 2018 Feb; 26(2):132-144. PMID: 28867148.
      View in: PubMed
    3. Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol. 2017 Oct; 2(10):1425-1434. PMID: 28784982.
      View in: PubMed
    4. Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P. Erratum: Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol. 2017 Jun 12; 2:17107. PMID: 28604710.
      View in: PubMed
    5. Paul BG, Burstein D, Castelle CJ, Handa S, Arambula D, Czornyj E, Thomas BC, Ghosh P, Miller JF, Banfield JF, Valentine DL. Retroelement-guided protein diversification abounds in vast lineages of Bacteria and Archaea. Nat Microbiol. 2017 Apr 03; 2:17045. PMID: 28368387.
      View in: PubMed
    6. Döhrmann S, LaRock CN, Anderson EL, Cole JN, Ryali B, Stewart C, Nonejuie P, Pogliano J, Corriden R, Ghosh P, Nizet V. Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones. Sci Rep. 2017 Feb 21; 7:43039. PMID: 28220899.
      View in: PubMed
    7. Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P. Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol. 2016 Sep 05; 1(11):16155. PMID: 27595425.
      View in: PubMed
    8. Handa S, Paul BG, Miller JF, Valentine DL, Ghosh P. Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements. BMC Struct Biol. 2016 08 31; 16(1):13. PMID: 27578274.
      View in: PubMed
    9. LaRock CN, Döhrmann S, Todd J, Corriden R, Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet V. Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing. Cell Host Microbe. 2015 Oct 14; 18(4):471-7. PMID: 26468750; PMCID: PMC4636435 [Available on 10/14/16].
    10. Paul BG, Bagby SC, Czornyj E, Arambula D, Handa S, Sczyrba A, Ghosh P, Miller JF, Valentine DL. Targeted diversity generation by intraterrestrial archaea and archaeal viruses. Nat Commun. 2015 Mar 23; 6:6585. PMID: 25798780; PMCID: PMC4372165.
    11. Guo H, Arambula D, Ghosh P, Miller JF. Diversity-generating Retroelements in Phage and Bacterial Genomes. Microbiol Spectr. 2014 Dec; 2(6). PMID: 26104433; PMCID: PMC4498404.
    12. Henningham A, Yamaguchi M, Aziz RK, Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J, Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV, Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole JN. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J Biol Chem. 2014 Nov 14; 289(46):32303-15. PMID: 25266727; PMCID: PMC4231703.
    13. Anderson EL, Cole JN, Olson J, Ryba B, Ghosh P, Nizet V. The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 group A Streptococcus. J Biol Chem. 2014 Feb 07; 289(6):3539-46. PMID: 24356958; PMCID: PMC3916555.
    14. Mukerjea R, Ghosh P. Functionally essential interaction between Yersinia YscO and the T3S4 domain of YscP. J Bacteriol. 2013 Oct; 195(20):4631-8. PMID: 23935040; PMCID: PMC3807450.
    15. Arambula D, Wong W, Medhekar BA, Guo H, Gingery M, Czornyj E, Liu M, Dey S, Ghosh P, Miller JF. Surface display of a massively variable lipoprotein by a Legionella diversity-generating retroelement. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8212-7. PMID: 23633572; PMCID: PMC3657778.
    16. Uchiyama S, Andreoni F, Zürcher C, Schilcher K, Ender M, Madon J, Matt U, Ghosh P, Nizet V, Schuepbach RA, Zinkernagel AS. Coiled-coil irregularities of the M1 protein structure promote M1-fibrinogen interaction and influence group A Streptococcus host cell interactions and virulence. J Mol Med (Berl). 2013 Jul; 91(7):861-9. PMID: 23443671; PMCID: PMC3695690.
    17. Hui F, Scheib U, Hu Y, Sommer RJ, Aroian RV, Ghosh P. Structure and glycolipid binding properties of the nematicidal protein Cry5B. Biochemistry. 2012 Dec 11; 51(49):9911-21. PMID: 23150986; PMCID: PMC3567309.
    18. Gamez A, Mukerjea R, Alayyoubi M, Ghassemian M, Ghosh P. Structure and interactions of the cytoplasmic domain of the Yersinia type III secretion protein YscD. J Bacteriol. 2012 Nov; 194(21):5949-58. PMID: 22942247; PMCID: PMC3486071.
    19. Bzymek KP, Hamaoka BY, Ghosh P. Two translation products of Yersinia yscQ assemble to form a complex essential to type III secretion. Biochemistry. 2012 Feb 28; 51(8):1669-77. PMID: 22320351; PMCID: PMC3289748.
    20. Machebœuf P, Ghosh P. [Structural basis for streptococcal toxic shock syndrome]. Med Sci (Paris). 2011 Oct; 27(10):814-6. PMID: 22027416.
      View in: PubMed
    21. Le Coq J, Ghosh P. Conservation of the C-type lectin fold for massive sequence variation in a Treponema diversity-generating retroelement. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14649-53. PMID: 21873231; PMCID: PMC3167528.
    22. Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature. 2011 Apr 07; 472(7341):64-8. PMID: 21475196; PMCID: PMC3268815.
    23. Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV. Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog. 2011 Mar; 7(3):e1001314. PMID: 21408619; PMCID: PMC3048360.
    24. Hanes MS, Reynolds KA, McNamara C, Ghosh P, Bonomo RA, Kirsch JF, Handel TM. Specificity and cooperativity at ß-lactamase position 104 in TEM-1/BLIP and SHV-1/BLIP interactions. Proteins. 2011 Apr; 79(4):1267-76. PMID: 21294157; PMCID: PMC3417816.
    25. Ghosh P. The nonideal coiled coil of M protein and its multifarious functions in pathogenesis. Adv Exp Med Biol. 2011; 715:197-211. PMID: 21557065.
      View in: PubMed
    26. Pentecost M, Kumaran J, Ghosh P, Amieva MR. Listeria monocytogenes internalin B activates junctional endocytosis to accelerate intestinal invasion. PLoS Pathog. 2010 May 13; 6(5):e1000900. PMID: 20485518; PMCID: PMC2869327.
    27. Rodgers L, Mukerjea R, Birtalan S, Friedberg D, Ghosh P. A solvent-exposed patch in chaperone-bound YopE is required for translocation by the type III secretion system. J Bacteriol. 2010 Jun; 192(12):3114-22. PMID: 20382763; PMCID: PMC2901707.
    28. Singh RK, Lau D, Noviello CM, Ghosh P, Guatelli JC. An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex. PLoS One. 2009 Dec 18; 4(12):e8364. PMID: 20020046; PMCID: PMC2791223.
    29. Lauth X, von Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V. M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun. 2009; 1(3):202-14. PMID: 20375578; PMCID: PMC3241932.
    30. Miller JL, Le Coq J, Hodes A, Barbalat R, Miller JF, Ghosh P. Selective ligand recognition by a diversity-generating retroelement variable protein. PLoS Biol. 2008 Jun 03; 6(6):e131. PMID: 18532877; PMCID: PMC2408619.
    31. Rodgers L, Gamez A, Riek R, Ghosh P. The type III secretion chaperone SycE promotes a localized disorder-to-order transition in the natively unfolded effector YopE. J Biol Chem. 2008 Jul 25; 283(30):20857-63. PMID: 18502763; PMCID: PMC2475703.
    32. Hrtska SC, Kemp MM, Muñoz EM, Azizad O, Banerjee M, Raposo C, Kumaran J, Ghosh P, Linhardt RJ. Investigation of the mechanism of binding between internalin B and heparin using surface plasmon resonance. Biochemistry. 2007 Mar 13; 46(10):2697-706. PMID: 17305366; PMCID: PMC2034450.
    33. Mikolosko J, Bobyk K, Zgurskaya HI, Ghosh P. Conformational flexibility in the multidrug efflux system protein AcrA. Structure. 2006 Mar; 14(3):577-87. PMID: 16531241; PMCID: PMC1997295.
    34. Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE. Identification of a bacterial type III effector family with G protein mimicry functions. Cell. 2006 Jan 13; 124(1):133-45. PMID: 16413487.
      View in: PubMed
    35. Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE. Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):927-32. PMID: 16410353; PMCID: PMC1347996.
    36. McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P. The C-type lectin fold as an evolutionary solution for massive sequence variation. Nat Struct Mol Biol. 2005 Oct; 12(10):886-92. PMID: 16170324.
      View in: PubMed
    37. Ghosh P. Process of protein transport by the type III secretion system. Microbiol Mol Biol Rev. 2004 Dec; 68(4):771-95. PMID: 15590783; PMCID: PMC539011.
    38. Chatterji A, Ochoa W, Shamieh L, Salakian SP, Wong SM, Clinton G, Ghosh P, Lin T, Johnson JE. Chemical conjugation of heterologous proteins on the surface of Cowpea mosaic virus. Bioconjug Chem. 2004 Jul-Aug; 15(4):807-13. PMID: 15264868.
      View in: PubMed
    39. Marino M, Banerjee M, Copp J, Dramsi S, Chapman T, van der Geer P, Cossart P, Ghosh P. Characterization of the calcium-binding sites of Listeria monocytogenes InlB. Biochem Biophys Res Commun. 2004 Apr 02; 316(2):379-86. PMID: 15020228.
      View in: PubMed
    40. Banerjee M, Copp J, Vuga D, Marino M, Chapman T, van der Geer P, Ghosh P. GW domains of the Listeria monocytogenes invasion protein InlB are required for potentiation of Met activation. Mol Microbiol. 2004 Apr; 52(1):257-71. PMID: 15049825.
      View in: PubMed
    41. Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, Ghosh P, Moran A, Predergast MM, Tromp G, Williams CJ, Inohara N, Núñez G. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J. 2004 Apr 07; 23(7):1587-97. PMID: 15044951; PMCID: PMC391079.
    42. Buetow L, Ghosh P. Structural elements required for deamidation of RhoA by cytotoxic necrotizing factor 1. Biochemistry. 2003 Nov 11; 42(44):12784-91. PMID: 14596592.
      View in: PubMed
    43. Phillips RM, Six DA, Dennis EA, Ghosh P. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J Biol Chem. 2003 Oct 17; 278(42):41326-32. PMID: 12915403.
      View in: PubMed
    44. Lawton JA, Ghosh P. Novel therapeutic strategies based on toll-like receptor signaling. Curr Opin Chem Biol. 2003 Aug; 7(4):446-51. PMID: 12941417.
      View in: PubMed
    45. Copp J, Marino M, Banerjee M, Ghosh P, van der Geer P. Multiple regions of internalin B contribute to its ability to turn on the Ras-mitogen-activated protein kinase pathway. J Biol Chem. 2003 Mar 07; 278(10):7783-9. PMID: 12488439.
      View in: PubMed
    46. Marino M, Banerjee M, Jonquières R, Cossart P, Ghosh P. GW domains of the Listeria monocytogenes invasion protein InlB are SH3-like and mediate binding to host ligands. EMBO J. 2002 Nov 01; 21(21):5623-34. PMID: 12411480; PMCID: PMC131055.
    47. Que X, Ngo H, Lawton J, Gray M, Liu Q, Engel J, Brinen L, Ghosh P, Joiner KA, Reed SL. The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. J Biol Chem. 2002 Jul 12; 277(28):25791-7. PMID: 12000756.
      View in: PubMed
    48. Birtalan SC, Phillips RM, Ghosh P. Three-dimensional secretion signals in chaperone-effector complexes of bacterial pathogens. Mol Cell. 2002 May; 9(5):971-80. PMID: 12049734.
      View in: PubMed
    49. Buetow L, Flatau G, Chiu K, Boquet P, Ghosh P. Strategies for the structural determination of the catalytic domain of Escherichia coli cytotoxic necrotizing factor 1. Acta Crystallogr D Biol Crystallogr. 2002 Feb; 58(Pt 2):366-9. PMID: 11807279.
      View in: PubMed
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