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    Vijay Sharma

    TitleSenate Emeritus
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0652
    CA La Jolla 92093
    Phone858-822-2918
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      Collapse Research 
      Collapse Research Activities and Funding
      ACTIVATION OF GUANYLATE CYCLASE BY NITRIC OXIDE
      NIH/NHLBI R01HL048014Feb 1, 1993 - Jan 31, 1998
      Role: Principal Investigator
      MECHANISM OF REACTIONS OF HEMOGLOBIN WITH LIGANDS
      NIH/NHLBI R55HL031159Sep 1, 1976 - Sep 29, 1995
      Role: Principal Investigator
      MECHANISM OF REACTIONS OF HEMOGLOBIN WITH LIGANDS
      NIH/NHLBI R01HL031159Sep 1, 1976 - Sep 29, 1992
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Brenner M, Kim JG, Mahon SB, Lee J, Kreuter KA, Blackledge W, Mukai D, Patterson S, Mohammad O, Sharma V, Boss GR. Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity. Ann Emerg Med. 2010 Apr; 55(4):352-63. PMID: 20045579.
        View in: PubMed
      2. Brenner M, Mahon SB, Lee J, Kim J, Mukai D, Goodman S, Kreuter KA, Ahdout R, Mohammad O, Sharma V, Blackledge W, Boss GR. Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring. J Biomed Opt. 2010 Jan-Feb; 15(1):017001. PMID: 20210475.
        View in: PubMed
      3. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma V, Pilz RB, Bigby TD, Boss GR. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 1; 197(3):457-64. PMID: 18199034.
        View in: PubMed
      4. Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL, Dillmann WH, Sharma V, Pilz RB, Bigby TD, Boss GR. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood). 2007 Dec; 232(11):1432-40. PMID: 18040067.
        View in: PubMed
      5. Broderick KE, Balasubramanian M, Chan A, Potluri P, Feala J, Belke DD, McCulloch A, Sharma V, Pilz RB, Bigby TD, Boss GR. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Exp Biol Med (Maywood). 2007 Jun; 232(6):789-98. PMID: 17526771.
        View in: PubMed
      6. Broderick KE, Feala J, McCulloch A, Paternostro G, Sharma V, Pilz RB, Boss GR. The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis. FASEB J. 2006 Sep; 20(11):1865-73. PMID: 16940158.
        View in: PubMed
      7. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma V, Pilz RB, Boss GR. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. PMID: 16636313.
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      8. Kambo A, Sharma V, Casteel DE, Woods VL, Pilz RB, Boss GR. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. PMID: 15647267.
        View in: PubMed
      9. Broderick KE, Singh V, Zhuang S, Kambo A, Chen JC, Sharma V, Pilz RB, Boss GR. Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol Chem. 2005 Mar 11; 280(10):8678-85. PMID: 15632180.
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      10. Sharma V, Pilz RB, Boss GR, Magde D. Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide. Biochemistry. 2003 Jul 29; 42(29):8900-8. PMID: 12873151.
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      11. Zemojtel T, Scheele JS, Martásek P, Masters BS, Sharma V, Magde D. Role of the interdomain linker probed by kinetics of CO ligation to an endothelial nitric oxide synthase mutant lacking the calmodulin binding peptide (residues 503-517 in bovine). Biochemistry. 2003 Jun 3; 42(21):6500-6. PMID: 12767233.
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      12. Danishpajooh IO, Gudi T, Chen Y, Kharitonov VG, Sharma V, Boss GR. Nitric oxide inhibits methionine synthase activity in vivo and disrupts carbon flow through the folate pathway. J Biol Chem. 2001 Jul 20; 276(29):27296-303. PMID: 11371572.
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      13. Sharma V, Magde D. Activation of soluble guanylate cyclase by carbon monoxide and nitric oxide: a mechanistic model. Methods. 1999 Dec; 19(4):494-505. PMID: 10581149.
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      14. Kharitonov VG, Sharma V, Magde D, Koesling D. Kinetics and equilibria of soluble guanylate cyclase ligation by CO: effect of YC-1. Biochemistry. 1999 Aug 17; 38(33):10699-706. PMID: 10451364.
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      15. Scheele JS, Bruner E, Kharitonov VG, Martásek P, Roman LJ, Masters BS, Sharma V, Magde D. Kinetics of NO ligation with nitric-oxide synthase by flash photolysis and stopped-flow spectrophotometry. J Biol Chem. 1999 May 7; 274(19):13105-10. PMID: 10224063.
        View in: PubMed
      16. Sharma V, Magde D, Kharitonov VG, Koesling D. Soluble guanylate cyclase: effect of YC-1 on ligation kinetics with carbon monoxide. Biochem Biophys Res Commun. 1999 Jan 8; 254(1):188-91. PMID: 9920755.
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      17. Kharitonov VG, Russwurm M, Magde D, Sharma V, Koesling D. Dissociation of nitric oxide from soluble guanylate cyclase. Biochem Biophys Res Commun. 1997 Oct 9; 239(1):284-6. PMID: 9345311.
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      18. Kharitonov VG, Sharma V, Magde D, Koesling D. Kinetics of nitric oxide dissociation from five- and six-coordinate nitrosyl hemes and heme proteins, including soluble guanylate cyclase. Biochemistry. 1997 Jun 3; 36(22):6814-8. PMID: 9184164.
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      19. Scheele JS, Kharitonov VG, Martásek P, Roman LJ, Sharma V, Masters BS, Magde D. Kinetics of CO ligation with nitric-oxide synthase by flash photolysis and stopped-flow spectrophotometry. J Biol Chem. 1997 May 9; 272(19):12523-8. PMID: 9139703.
        View in: PubMed
      20. Kharitonov VG, Sundquist AR, Sharma V. Kinetics of nitrosation of thiols by nitric oxide in the presence of oxygen. J Biol Chem. 1995 Nov 24; 270(47):28158-64. PMID: 7499306.
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      21. Kharitonov VG, Sharma V, Pilz RB, Magde D, Koesling D. Basis of guanylate cyclase activation by carbon monoxide. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2568-71. PMID: 7708686.
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      22. Duprat AF, Traylor TG, Wu GZ, Coletta M, Sharma V, Walda KN, Magde D. Myoglobin-NO at low pH: free four-coordinated heme in the protein pocket. Biochemistry. 1995 Feb 28; 34(8):2634-44. PMID: 7873545.
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      23. Walda KN, Liu XY, Sharma V, Magde D. Geminate recombination of diatomic ligands CO, O2, and NO with myoglobin. Biochemistry. 1994 Mar 1; 33(8):2198-209. PMID: 8117677.
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      24. Kharitonov VG, Sundquist AR, Sharma V. Kinetics of nitric oxide autoxidation in aqueous solution. J Biol Chem. 1994 Feb 25; 269(8):5881-3. PMID: 8119931.
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      25. Sharma V. Double mixing methods for kinetic studies of ligand binding in partially liganded intermediates of hemoglobin. Methods Enzymol. 1994; 232:430-45. PMID: 8057873.
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      26. Sharma V, Valji K, Bookstein JJ. Gastrointestinal hemorrhage in AIDS: arteriographic diagnosis and transcatheter treatment. Radiology. 1992 Nov; 185(2):447-51. PMID: 1410352.
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      27. Bandyopadhyay D, Magde D, Traylor TG, Sharma V. Quaternary structure and geminate recombination in hemoglobin: flow-flash studies on alpha 2CO beta 2 and alpha 2 beta 2CO. Biophys J. 1992 Sep; 63(3):673-81. PMID: 1420906.
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      28. Traylor TG, Sharma V. Why NO? Biochemistry. 1992 Mar 24; 31(11):2847-9. PMID: 1348002.
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      29. Idriss SD, Pilz RB, Sharma V, Boss GR. Studies on cytosolic guanylate cyclase from human placenta. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):312-20. PMID: 1347448.
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      30. Sharma V, Bandyopadhyay D, Berjis M, Rifkind J, Boss GR. Double-mixing kinetic studies of the reactions of monoliganded species of hemoglobin: alpha 2(CO)1 beta 2 and alpha 2 beta 2(CO)1. J Biol Chem. 1991 Dec 25; 266(36):24492-7. PMID: 1761549.
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      31. Berjis M, Sharma V. Double mixing stopped-flow method for the study of equilibria and kinetics of dimer-tetramer association of hemoglobins: studies on Hb Carp, Hb A, and Hb Rothschild. Anal Biochem. 1991 Aug 1; 196(2):223-8. PMID: 1776671.
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      32. Berjis M, Bandyopadhyay D, Sharma V. Double-mixing kinetic studies of the reactions of methyl isocyanide and CO with diliganded intermediates of hemoglobin: alpha 2CO beta 2 and alpha 2 beta 2CO. Biochemistry. 1990 Oct 30; 29(43):10106-13. PMID: 2271642.
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      33. Bandyopadhyay D, Walda KN, Magde D, Traylor TG, Sharma V. Quaternary structure and the geminate recombination of carp hemoglobin with methylisocyanide. Biochem Biophys Res Commun. 1990 Aug 31; 171(1):306-12. PMID: 2393395.
        View in: PubMed
      34. Sharma V. Kinetic studies on partially liganded species of carboxyhemoglobin: (alpha 1CO-beta 1CO)alpha 2 beta 2 or (alpha 2CO beta 2CO)alpha 1 beta 1. J Biol Chem. 1989 Jun 25; 264(18):10582-8. PMID: 2732240.
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      35. Sharma V. Kinetic studies on partially liganded species of carboxyhemoglobin: alpha 2 CO beta 2 and alpha 2 beta 2CO. J Biol Chem. 1988 Feb 15; 263(5):2292-8. PMID: 3339010.
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      36. Sharma V, Traylor TG, Gardiner R, Mizukami H. Reaction of nitric oxide with heme proteins and model compounds of hemoglobin. Biochemistry. 1987 Jun 30; 26(13):3837-43. PMID: 3651417.
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