Caitlin Costello

Photo of Caitlin Costello
Title(s)Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Research Interests
    As a member of the Division of Blood and Marrow Transplantation, Dr Costello is dedicated to providing excellent care for patients with a variety of hematologic malignancies, with a specific focus in lymphoproliferative disorders and bone marrow transplantation. Dr Costello’s research interests focus particularly on the refinement of the management and treatment of multiple myeloma. She is dedicated to conducting clinical trials with novel agents and treatment strategies to expand the therapeutic options for patients with multiple myeloma. As we enter the age of personalized medicine, Dr. Costello is principally interested in developing treatment strategies that are specific to the most finite genetic and molecular details of each individual patient’s disease.

    Education and Training
    BA - Biology, Harvard University, Cambridge, MA - 2002
    MD - Medicine, Tufts University, School of Medicine, Boston, MA - 2006
    Internship/Residency - Internal Medicine, New York Presbyterial/Weill Cornell Medical Center, New York, NY - 2006-2009
    Fellowship - Hematology/Oncology, University of California, San Diego, CA - 2009-2012

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    Collapse awards and honors
    Harvard University2002Cum Laude
    2004Robert J. Fahey Award for Compassion in Doctoring
    2006Worth F Bloom Award for High Standard of Excellence and Level of Compassion
    2010  - 2012Akliviadis Vasiliadis Fellowship Award for Clinical Research
    2011American Society of Hematology Abstract Achievement Award
    2012American Society of Clinical Oncology Travel Award

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    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Integrating Recent Evidence and Expert Perspectives Into the Management of Multiple Myeloma: Consensus Recommendations From the 2025 Bridging the Gaps Conference. Am J Hematol. 2026 Jul; 101(7):1676-1686. Chari A, Costello C, Krishnan A, Patel K, Banerjee R, Berdeja JG, Biran N, Callander N, Costa LJ, Dhakal B, Gasparetto C, Hansen DK, Kumar A, Nooka AK, Pan D, Richard S. PMID: 42014940.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Choosing Wisely in First Relapse of Multiple Myeloma: Expert Insights on Treatment Selection. Clin Lymphoma Myeloma Leuk. 2026 Jun; 26(6):e752-e766. Al Hadidi S, Costello C, Costa LJ, Dhakal B, Georges P, Gajra A, Lin Y, Bhargava RS, Paner-Straseviciute A, Vij R. PMID: 41936482.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Optimal conditions for quantification of IRF4 mRNA and protein as a correlative biomarker in clinical cancer studies. J Transl Med. 2026 03 16; 24(1). Hartman JD, Vicenzi S, Tong AA, Avsharian LC, Vora AA, Costello C, Deichaite I, Crews LA. PMID: 41840398; PMCID: PMC13104480.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A phase 1 study of blinatumomab/lenalidomide in relapsed/refractory B-cell lymphoma: toxicity, efficacy, and correlative analysis. Blood Adv. 2026 02 24; 10(4):1153-1162. Tuscano JM, Othman T, Frankel P, Ruel C, Poh C, Herbert S, Maverakis E, Merleev AA, Luxardi G, Abedi M, Ranganathan R, Modi D, Zain J, Budde EL, Mei M, Rosenberg AS, Hoeg RT, Costello C, Foss FM, William BM, Holland HK, Sharon E, Streicher H, Danilov AV, Newman E. PMID: 41213001; PMCID: PMC12917533.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    5. TSCM-predominant allogeneic anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma: preclinical characterization and interim results from a phase 1 trial. Nat Commun. 2025 Nov 24; 16(1):10050. Tseng H, Dholaria B, Cranert SA, Richter M, Marquez KS, Cho BS, Bacong A, McArthur K, Eskew JD, McCaigue J, Haag S, Krasny A, Solimine B, Coffey MJ, Loyola A, Kwong J, Shune L, Kin A, Costello CL, Kocoglu MH, Ramakrishnan A, Namini H, Martin CE, Belani R, Coronella J, Shedlock DJ. PMID: 41285709; PMCID: PMC12644732.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    6. Daratumumab plus lenalidomide maintenance in newly diagnosed multiple myeloma after transplant: AURIGA subgroup analyses. Blood Cancer J. 2025 10 06; 15(1):154. Foster L, Anderson LD, Chung A, Chaulagain CP, Pettijohn E, Cowan AJ, Costello C, Larson S, Sborov DW, Shain KH, Silbermann R, Voorhees P, Krevvata M, Pei H, Patel S, Khare V, Cortoos A, Carson R, Lin TS, Badros A. PMID: 41053004; PMCID: PMC12500855.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    7. A prospective clinical trial of GVHD prophylaxis with posttransplant cyclophosphamide and abatacept. Blood Adv. 2025 Aug 26; 9(16):4336-4344. Koura D, Dykes K, Goodman A, Costello C, Mulroney C, Mangan JK, Tanaka TN, Ball ED, Hamdan A, Jeong AR, Mirocha J, Zhang Q, Ogrodnik P, McConnell K, Maroge JJ, Padilla M, Morris GP, Tzachanis D. PMID: 40554429; PMCID: PMC12402362.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Anaesthesia Considerations for an Adult with Hurler Syndrome. Ir Med J. 2025 04 23; 118(4):63. Ryan P, Costello C. PMID: 40352058.
      View in: PubMed   Mentions:    Fields:    
    9. Expert Perspectives on Current Challenges and Emerging Approaches for Multiple Myeloma: Narrative Review of an Inaugural Bridging the Gaps in Leukemia, Lymphoma, and Multiple Myeloma. Clin Lymphoma Myeloma Leuk. 2025 Sep; 25(9):635-645. Chari A, Bal S, Ailawadhi S, Krishnan A, Patel KK, Berdeja JG, Garfall A, Callander N, Banerjee R, Alsina M, Nooka AK, Dhakal B, Gasparetto C, Costello C. PMID: 40175263.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Daratumumab with lenalidomide as maintenance after transplant in newly diagnosed multiple myeloma: the AURIGA study. Blood. 2025 01 16; 145(3):300-310. Badros A, Foster L, Anderson LD, Chaulagain CP, Pettijohn E, Cowan AJ, Costello C, Larson S, Sborov DW, Shain KH, Silbermann R, Shah N, Chung A, Krevvata M, Pei H, Patel S, Khare V, Cortoos A, Carson R, Lin TS, Voorhees P. PMID: 39331724; PMCID: PMC11775507.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    11. Outcomes of Idecabtagene Vicleucel Therapy in Patients with Relapsed/Refractory Multiple Myeloma: A Single-Institution Experience. Biomedicines. 2024 Dec 27; 13(1). Trando A, Ghamsari F, Yeung P, Costello C, Saunders I, Jeong AR. PMID: 39857619; PMCID: PMC11759176.
      View in: PubMed   Mentions:
    12. A plain language summary of the final analysis of the GRIFFIN study of daratumumab plus lenalidomide, bortezomib, and dexamethasone for people with newly diagnosed multiple myeloma. Future Oncol. 2025 Jan; 21(1):25-49. Voorhees PM, Sborov DW, Laubach J, Kaufman JL, Reeves B, Rodriguez C, Silbermann R, Costa LJ, Anderson LD, Nathwani N, Shah N, Bumma N, Efebera YA, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Dinner S, Gries KS, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG. PMID: 39452950; PMCID: PMC11789466.
      View in: PubMed   Mentions: 1     Fields:    
    13. Daratumumab in transplant-eligible patients with newly diagnosed multiple myeloma: final analysis of clinically relevant subgroups in GRIFFIN. Blood Cancer J. 2024 07 08; 14(1):107. Chari A, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Silbermann R, Costa LJ, Anderson LD, Nathwani N, Shah N, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Pei H, Cortoos A, Patel S, Lin TS, Voorhees PM, Usmani SZ, Richardson PG. PMID: 38977707; PMCID: PMC11231363.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    14. A CD10-negative adult B-lymphoblastic leukaemia with amplification of KMT2A without rearrangement: A case report and review of the English literature. Br J Haematol. 2024 Jul; 205(1):364-367. Wang HY, Louis HMS, Costello CL, Murray SS, Dell'Aquila ML. PMID: 38735761.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Daratumumab-based quadruplet therapy for transplant-eligible newly diagnosed multiple myeloma with high cytogenetic risk. Blood Cancer J. 2024 04 22; 14(1):69. Callander NS, Silbermann R, Kaufman JL, Godby KN, Laubach J, Schmidt TM, Sborov DW, Medvedova E, Reeves B, Dhakal B, Rodriguez C, Chhabra S, Chari A, Bal S, Anderson LD, Dholaria BR, Nathwani N, Hari P, Shah N, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Pei H, Cortoos A, Patel S, Lin TS, Giri S, Costa LJ, Usmani SZ, Richardson PG, Voorhees PM. PMID: 38649340; PMCID: PMC11035596.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    16. Health-related quality of life in transplant-eligible patients with newly diagnosed multiple myeloma treated with daratumumab, lenalidomide, bortezomib, and dexamethasone: Patient-reported outcomes from GRIFFIN. Am J Hematol. 2024 07; 99(7):1257-1268. Silbermann R, Laubach J, Kaufman JL, Sborov DW, Reeves B, Rodriguez C, Chari A, Costa LJ, Anderson LD, Nathwani N, Shah N, Bumma N, Holstein SA, Costello C, Jakubowiak A, Orlowski RZ, Shain KH, Cowan AJ, Gries KS, Pei H, Cortoos A, Patel S, Lin TS, Voorhees PM, Usmani SZ, Richardson PG. PMID: 38622840.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    17. In-class transition from bortezomib-based therapy to IRd is an effective approach in newly diagnosed multiple myeloma. Future Oncol. 2024 Jan; 20(3):131-143. Rifkin RM, Costello CL, Birhiray RE, Kambhampati S, Richter J, Abonour R, Lee HC, Stokes M, Ren K, Stull DM, Cherepanov D, Bogard K, Noga SJ, Girnius S. PMID: 37807952.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial. Nat Med. 2023 10; 29(10):2570-2576. Bahlis NJ, Costello CL, Raje NS, Levy MY, Dholaria B, Solh M, Tomasson MH, Damore MA, Jiang S, Basu C, Skoura A, Chan EM, Trudel S, Jakubowiak A, Gasparetto C, Chu MP, Dalovisio A, Sebag M, Lesokhin AM. PMID: 37783970; PMCID: PMC10579053.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCellsCTClinical Trials
    19. Heart-liver-kidney transplantation for AL amyloidosis using normothermic recovery and storage from a donor following circulatory death: Short-term outcome in a first-in-world experience. Am J Transplant. 2023 02; 23(2):291-293. Brubaker AL, Urey MA, Taj R, Parekh JR, Berumen J, Kearns M, Shah M, Khan A, Kono Y, Ajmera V, Barman P, Tran H, Adler ED, Silva Enciso J, Asimakopoulos F, Costello C, Bower R, Sanchez R, Pretorius V, Schnickel GT. PMID: 36804136.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Newly diagnosed multiple myeloma: making sense of the menu. Hematology Am Soc Hematol Educ Program. 2022 12 09; 2022(1):539-550. Costello CL. PMID: 36485145; PMCID: PMC9820388.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Rates of Influenza and Pneumococcal Vaccination and Correlation With Survival in Multiple Myeloma Patients. Clin Lymphoma Myeloma Leuk. 2023 03; 23(3):e171-e181. Thompson MA, Boccadoro M, Leleu X, Vela-Ojeda J, van Rhee F, Weisel KC, Rifkin RM, Usmani SZ, Hájek R, Cook G, Abonour R, Armour M, Morgan KE, Yeh SP, Costello CL, Berdeja JG, Davies FE, Zonder JA, Lee HC, Omel J, Spencer A, Terpos E, Hungria VTM, Puig N, Fu C, Ferrari RH, Ren K, Stull DM, Chari A. PMID: 36641358.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    22. Sensitive intranuclear flow cytometric quantification of IRF4 protein in multiple myeloma and normal human hematopoietic cells. STAR Protoc. 2021 06 18; 2(2):100565. Vora AA, Mondala PK, Costello C, MacLeod AR, Crews LA. PMID: 34136833; PMCID: PMC8176358.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Optimizing transfusion management of multiple myeloma patients receiving daratumumab-based regimens. Transfusion. 2021 07; 61(7):2054-2063. Phou S, Costello C, Kopko PM, Allen ES. PMID: 33960433.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Ixazomib-lenalidomide-dexamethasone in routine clinical practice: effectiveness in relapsed/refractory multiple myeloma. Future Oncol. 2021 Jul; 17(19):2499-2512. Hájek R, Minarík J, Straub J, Pour L, Jungova A, Berdeja JG, Boccadoro M, Brozova L, Spencer A, van Rhee F, Vela-Ojeda J, Thompson MA, Abonour R, Chari A, Cook G, Costello CL, Davies FE, Hungria VT, Lee HC, Leleu X, Puig N, Rifkin RM, Terpos E, Usmani SZ, Weisel KC, Zonder JA, Barinová M, Kuhn M, Šilar J, Cápková L, Galvez K, Lu J, Elliott J, Stull DM, Ren K, Maisnar V. PMID: 33769076.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. Management of patients with multiple myeloma beyond the clinical-trial setting: understanding the balance between efficacy, safety and tolerability, and quality of life. Blood Cancer J. 2021 02 18; 11(2):40. Terpos E, Mikhael J, Hajek R, Chari A, Zweegman S, Lee HC, Mateos MV, Larocca A, Ramasamy K, Kaiser M, Cook G, Weisel KC, Costello CL, Elliott J, Palumbo A, Usmani SZ. PMID: 33602913; PMCID: PMC7891472.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    26. Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption. Cell Stem Cell. 2021 04 01; 28(4):623-636.e9. Mondala PK, Vora AA, Zhou T, Lazzari E, Ladel L, Luo X, Kim Y, Costello C, MacLeod AR, Jamieson CHM, Crews LA. PMID: 33476575; PMCID: PMC8026723.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    27. Supportive Care in Multiple Myeloma. Curr Hematol Malig Rep. 2020 04; 15(2):56-61. Guzdar A, Costello C. PMID: 32172361.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    28. Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression. Proc Natl Acad Sci U S A. 2019 12 03; 116(49):24881-24891. Banerjee S, Wei T, Wang J, Lee JJ, Gutierrez HL, Chapman O, Wiley SE, Mayfield JE, Tandon V, Juarez EF, Chavez L, Liang R, Sah RL, Costello C, Mesirov JP, de la Vega L, Cooper KL, Dixon JE, Xiao J, Lei X. PMID: 31754034; PMCID: PMC6900511.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    29. The future of checkpoint inhibition in multiple myeloma? Lancet Haematol. 2019 09; 6(9):e439-e440. Costello C. PMID: 31327688.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    30. INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma. Future Oncol. 2019 May; 15(13):1411-1428. Costello C, Davies FE, Cook G, Vela-Ojeda J, Omel J, Rifkin RM, Berdeja J, Puig N, Usmani SZ, Weisel K, Zonder JA, Terpos E, Spencer A, Leleu X, Boccadoro M, Thompson MA, Romanus D, Stull DM, Hungria V. PMID: 30816809; PMCID: PMC6854441.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    31. Ibrutinib alone or with dexamethasone for relapsed or relapsed and refractory multiple myeloma: phase 2 trial results. Br J Haematol. 2018 03; 180(6):821-830. Richardson PG, Bensinger WI, Huff CA, Costello CL, Lendvai N, Berdeja JG, Anderson LD, Siegel DS, Lebovic D, Jagannath S, Laubach JP, Stockerl-Goldstein KE, Kwei L, Clow F, Elias L, Salman Z, Graef T, Bilotti E, Vij R. PMID: 29435979; PMCID: PMC5873373.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    32. Therapy sequencing strategies in multiple myeloma: who, what and why? Future Oncol. 2018 01; 14(2):95-99. Costello C, Mikhael JR. PMID: 29219615.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun. 2017 12 04; 8(1):1922. Lazzari E, Mondala PK, Santos ND, Miller AC, Pineda G, Jiang Q, Leu H, Ali SA, Ganesan AP, Wu CN, Costello C, Minden M, Chiaramonte R, Stewart AK, Crews LA, Jamieson CHM. PMID: 29203771; PMCID: PMC5715072.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    34. Next Generation Sequencing Reveals Potentially Actionable Alterations in the Majority of Patients with Lymphoid Malignancies. JCO Precis Oncol. 2017 06; 1. Goodman AM, Choi M, Wieduwilt M, Mulroney C, Costello C, Frampton G, Miller V, Kurzrock R. PMID: 28681041; PMCID: PMC5495179.
      View in: PubMed   Mentions: 15     Fields:    
    35. An update on the role of daratumumab in the treatment of multiple myeloma. Ther Adv Hematol. 2017 Jan; 8(1):28-37. Costello C. PMID: 28042457; PMCID: PMC5167079.
      View in: PubMed   Mentions: 16  
    36. Ipilimumab for Patients with Relapse after Allogeneic Transplantation. N Engl J Med. 2016 Jul 14; 375(2):143-53. Davids MS, Kim HT, Bachireddy P, Costello C, Liguori R, Savell A, Lukez AP, Avigan D, Chen YB, McSweeney P, LeBoeuf NR, Rooney MS, Bowden M, Zhou CW, Granter SR, Hornick JL, Rodig SJ, Hirakawa M, Severgnini M, Hodi FS, Wu CJ, Ho VT, Cutler C, Koreth J, Alyea EP, Antin JH, Armand P, Streicher H, Ball ED, Ritz J, Bashey A, Soiffer RJ, Leukemia and Lymphoma Society Blood Cancer Research Partnership. PMID: 27410923; PMCID: PMC5149459.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansCellsCTClinical Trials
    37. Multiple Myeloma, Version 2.2016: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2015 Nov; 13(11):1398-435. Anderson KC, Alsina M, Atanackovic D, Biermann JS, Chandler JC, Costello C, Djulbegovic B, Fung HC, Gasparetto C, Godby K, Hofmeister C, Holmberg L, Holstein S, Huff CA, Kassim A, Krishnan AY, Kumar SK, Liedtke M, Lunning M, Raje N, Singhal S, Smith C, Somlo G, Stockerl-Goldstein K, Treon SP, Weber D, Yahalom J, Shead DA, Kumar R, National Comprehensive Cancer Network. PMID: 26553768; PMCID: PMC4891187.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    38. Idiotype immunization following high-dose therapy and autologous stem cell transplantation for non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2012 Feb; 18(2):257-64. Holman PR, Costello C, deMagalhaes-Silverman M, Corringham S, Castro J, Ball ED. PMID: 21736867.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
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