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Robert Signer

Title(s)Assistant Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0658
La Jolla CA 92093
Phone858-534-0732
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    Collapse Biography 
    Collapse Education and Training
    UT Southwestern Medical CenterPostdoctoral Fellow2015Children's Research Institute
    University of California, Los AngelesPh.D.2008Cellular and Molecular Pathology
    University of TorontoB.A.Sc.2003Engineering Science
    Collapse Awards and Honors
    American Society of Hematology2018Scholar Award
    Biomedical Excellence for Safer Transfusion Collaborative2017Scott Murphy Award
    V Foundation for Cancer Research2017Scholar Award
    Lund Stem Cell Center2014Distinguished International Young Investigator
    The Leukemia and Lymphoma Society2010  - 2013Fellow
    Canadian Institutes of Health Research2010  - 2013Fellow
    California Institute for Regenerative Medicine2006  - 2008Fellow

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting leukemia stem cells by disrupting translational fidelity
    Leukemia & Lymphoma Society, Mark Foundation for Cancer Research, Paul G. Allen Frontiers Group Blood Cancer Discoveries Grant (8025-20)Jul 1, 2020 - Jun 30, 2023
    Role: Principal Investigator
    Ex vivo hematopoietic stem cell growth mediated by the heat shock response
    NIH/NIDDK R01DK124775Mar 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Protein Homeostasis in Hematopoietic Stem Cells
    NIH/NIDDK R01DK116951Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. PLoS Pathog. 2017 07; 13(7):e1006509. Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell J, Bixby D, Markowitz N, Morrison SJ, Collins KL. PMID: 28732051.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    2. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nat Cell Biol. 2017 Jun; 19(6):626-638. Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J. PMID: 28504707.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    3. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. 2017 01 24; 18(4):947-960. Mgbemena VE, Signer RAJ, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. PMID: 28122244.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2017 01 26; 541(7638):558. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. PMID: 27919080.
      View in: PubMed   Mentions: 1     Fields:    
    5. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes Dev. 2016 08 01; 30(15):1698-703. Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. PMID: 27492367.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    6. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. 2016 06 14; 6(6):806-814. Porter SN, Cluster AS, Signer RAJ, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA. PMID: 27185281.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell. 2016 Apr 07; 18(4):456-66. Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H. PMID: 27044474.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    8. Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2016 Mar 17; 531(7594):323-8. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. PMID: 26958831.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    9. Cellular differences in protein synthesis regulate tissue homeostasis. Cell. 2014 Oct 09; 159(2):242-51. Buszczak M, Signer RA, Morrison SJ. PMID: 25303523.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    10. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife. 2014 May 07; 3:e02669. Mich JK, Signer RA, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ. PMID: 24843006.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    11. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014 May 01; 509(7498):49-54. Signer RA, Magee JA, Salic A, Morrison SJ. PMID: 24670665.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    12. Mechanisms that regulate stem cell aging and life span. Cell Stem Cell. 2013 Feb 07; 12(2):152-65. Signer RA, Morrison SJ. PMID: 23395443.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    13. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012 Jun 14; 119(24):5715-21. Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. PMID: 22555975.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 2010 Oct 07; 116(14):2522-30. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 20562326.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan; 9(1):57-62. Dorshkind K, Montecino-Rodriguez E, Signer RA. PMID: 19104499.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    16. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15; 22(22):3115-20. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 19056891.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    17. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007 Sep 15; 110(6):1831-9. Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. PMID: 17554060.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    18. Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp Gerontol. 2007 May; 42(5):391-5. Signer RA, Montecino-Rodriguez E, Dorshkind K. PMID: 17184948.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells