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Robert Signer

TitleAssistant Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0658
La Jolla CA 92093
Phone858-534-0732
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    Collapse Biography 
    Collapse Education and Training
    UT Southwestern Medical CenterPostdoctoral Fellow2015Children's Research Institute
    University of California, Los AngelesPh.D.2008Cellular and Molecular Pathology
    University of TorontoB.A.Sc.2003Engineering Science
    Collapse Awards and Honors
    American Society of Hematology2018Scholar Award
    Biomedical Excellence for Safer Transfusion Collaborative2017Scott Murphy Award
    V Foundation for Cancer Research2017Scholar Award
    Lund Stem Cell Center2014Distinguished International Young Investigator
    The Leukemia and Lymphoma Society2010  - 2013Fellow
    Canadian Institutes of Health Research2010  - 2013Fellow
    California Institute for Regenerative Medicine2006  - 2008Fellow

    Collapse Research 
    Collapse Research Activities and Funding
    Protein Homeostasis in Hematopoietic Stem Cells
    NIH R01DK116951Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kruta M, Signer R. Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells. Cell Stem Cell. 2018 Mar 01; 22(3):281-282. PMID: 29499142.
      View in: PubMed
    2. Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer R, Riddell J, Bixby D, Markowitz N, Morrison SJ, Collins KL. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. PLoS Pathog. 2017 07; 13(7):e1006509. PMID: 28732051.
      View in: PubMed
    3. Liu X, Zhang Y, Ni M, Cao H, Signer R, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nat Cell Biol. 2017 Jun; 19(6):626-638. PMID: 28504707.
      View in: PubMed
    4. Mgbemena VE, Signer R, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. 2017 01 24; 18(4):947-960. PMID: 28122244.
      View in: PubMed
    5. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer R, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2017 01 26; 541(7638):558. PMID: 27919080.
      View in: PubMed
    6. Signer R, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes Dev. 2016 08 01; 30(15):1698-703. PMID: 27492367; PMCID: PMC5002975.
    7. Porter SN, Cluster AS, Signer R, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. 2016 06 14; 6(6):806-14. PMID: 27185281; PMCID: PMC4911494.
    8. Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer R, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H. Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell. 2016 Apr 07; 18(4):456-66. PMID: 27044474; PMCID: PMC4826298 [Available on 04/07/17].
    9. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer R, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2016 Mar 17; 531(7594):323-8. PMID: 26958831.
      View in: PubMed
    10. Buszczak M, Signer R, Morrison SJ. Cellular differences in protein synthesis regulate tissue homeostasis. Cell. 2014 Oct 09; 159(2):242-51. PMID: 25303523; PMCID: PMC4222182.
    11. Mich JK, Signer R, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife. 2014 May 07; 3:e02669. PMID: 24843006; PMCID: PMC4038845.
    12. Signer R, Magee JA, Salic A, Morrison SJ. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014 May 01; 509(7498):49-54. PMID: 24670665; PMCID: PMC4015626.
    13. Signer R, Morrison SJ. Mechanisms that regulate stem cell aging and life span. Cell Stem Cell. 2013 Feb 07; 12(2):152-65. PMID: 23395443; PMCID: PMC3641677.
    14. Berent-Maoz B, Montecino-Rodriguez E, Signer R, Dorshkind K. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012 Jun 14; 119(24):5715-21. PMID: 22555975; PMCID: PMC3382931.
    15. Signer R, Montecino-Rodriguez E, Witte ON, Dorshkind K. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 2010 Oct 07; 116(14):2522-30. PMID: 20562326; PMCID: PMC2953887.
    16. Dorshkind K, Montecino-Rodriguez E, Signer R. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan; 9(1):57-62. PMID: 19104499.
      View in: PubMed
    17. Signer R, Montecino-Rodriguez E, Witte ON, Dorshkind K. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15; 22(22):3115-20. PMID: 19056891; PMCID: PMC2593609.
    18. Signer R, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007 Sep 15; 110(6):1831-9. PMID: 17554060; PMCID: PMC1976345.
    19. Signer R, Montecino-Rodriguez E, Dorshkind K. Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp Gerontol. 2007 May; 42(5):391-5. PMID: 17184948; PMCID: PMC1924911.