Robert Signer

Title(s)Associate Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    UT Southwestern Medical CenterPostdoctoral Fellow2015Children's Research Institute
    University of California, Los AngelesPh.D.2008Cellular and Molecular Pathology
    University of TorontoB.A.Sc.2003Engineering Science
    Collapse Awards and Honors
    American Society of Hematology2018Scholar Award
    Biomedical Excellence for Safer Transfusion Collaborative2017Scott Murphy Award
    V Foundation for Cancer Research2017Scholar Award
    Lund Stem Cell Center2014Distinguished International Young Investigator
    The Leukemia and Lymphoma Society2010  - 2013Fellow
    Canadian Institutes of Health Research2010  - 2013Fellow
    California Institute for Regenerative Medicine2006  - 2008Fellow
    Sanford Stem Cell Institute2023  - 2028Stellar Faculty Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the Proteostasis Network in Acute Myeloid Leukemia
    Curebound Targeted GrantSep 1, 2023 - Aug 31, 2024
    Role: Principal Investigator
    Transfer RNAs in Hematopoietic Stem Cell Function
    NIH R01HL165172Aug 1, 2023 - Jul 31, 2026
    Role: Co-Principal Investigator
    Synergistically Disrupting Proteostasis in Acute Myeloid Leukemia Stem Cells
    American Cancer Society CSCC-RSG-23-994830-01-CSCCJan 1, 2023 - Dec 31, 2026
    Role: Principal Investigator
    FACSymphony S6 Cell Sorter for Improving Basic, Clinical, and Translational Cancer Research Capabilities
    NIH S10OD032316Aug 22, 2022 - Jul 21, 2023
    Role: Principal Investigator
    The influence of proteostasis loss in aging hematopoietic stem cells on leukemia initiation
    NIH/NCI U01CA267031Sep 15, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Targeting leukemia stem cells by disrupting translational fidelity
    Leukemia & Lymphoma Society, Mark Foundation, Paul G. Allen Frontiers Group BCDG 8025-20Jul 1, 2020 - Jun 30, 2023
    Role: Principal Investigator
    Ex vivo hematopoietic stem cell growth mediated by the heat shock response
    NIH/NIDDK R01DK124775Mar 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Protein Homeostasis in Hematopoietic Stem Cells
    NIH/NIDDK R01DK116951Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica. 2023 Dec 01; 108(12):3464-3470. Zhang C, Cui X, Liu Y, Wang F, Signer R, Nattamai K, Zhou D, Zheng Y, Geiger H, Wan F, Liang Y. PMID: 37345464; PMCID: PMC10690908.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis. Cell Stem Cell. 2023 04 06; 30(4):460-472.e6. Chua BA, Lennan CJ, Sunshine MJ, Dreifke D, Chawla A, Bennett EJ, Signer RAJ. PMID: 36948186; PMCID: PMC10164413.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    3. Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification. Exp Hematol. 2021 12; 104:55-63. Challen GA, Pietras EM, Wallscheid NC, Signer RAJ. PMID: 34648848.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    4. Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging. Cell Stem Cell. 2021 11 04; 28(11):1950-1965.e6. Kruta M, Sunshine MJ, Chua BA, Fu Y, Chawla A, Dillingham CH, Hidalgo San Jose L, De Jong B, Zhou FJ, Signer RAJ. PMID: 34388375; PMCID: PMC8571035.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    5. Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis. Stem Cell Reports. 2021 01 12; 16(1):20-28. Magee JA, Signer RAJ. PMID: 33440178; PMCID: PMC7815942.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    6. ERADicating stem cells from their niche. Nat Cell Biol. 2020 10; 22(10):1155-1157. Lam K, Signer RAJ. PMID: 32958855.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Hematopoietic stem cell regulation by the proteostasis network. Curr Opin Hematol. 2020 07; 27(4):254-263. Chua BA, Signer RAJ. PMID: 32452878; PMCID: PMC7357843.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    8. Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells. Cell Stem Cell. 2020 02 06; 26(2):138-159. Chua BA, Van Der Werf I, Jamieson C, Signer RAJ. PMID: 32032524; PMCID: PMC7158223.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    9. Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal. Cell Rep. 2020 01 07; 30(1):69-80.e6. Hidalgo San Jose L, Sunshine MJ, Dillingham CH, Chua BA, Kruta M, Hong Y, Hatters DM, Signer RAJ. PMID: 31914399; PMCID: PMC7004491.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    10. Cell-type-specific quantification of protein synthesis in vivo. Nat Protoc. 2019 02; 14(2):441-460. Hidalgo San Jose L, Signer RAJ. PMID: 30610239; PMCID: PMC8105873.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    11. Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells. Cell Stem Cell. 2018 03 01; 22(3):281-282. Kruta M, Signer RAJ. PMID: 29499142.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. PLoS Pathog. 2017 07; 13(7):e1006509. Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell J, Bixby D, Markowitz N, Morrison SJ, Collins KL. PMID: 28732051; PMCID: PMC5540617.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    13. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nat Cell Biol. 2017 Jun; 19(6):626-638. Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J. PMID: 28504707; PMCID: PMC5771482.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    14. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep. 2017 01 24; 18(4):947-960. Mgbemena VE, Signer RAJ, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. PMID: 28122244; PMCID: PMC5267932.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2017 01 26; 541(7638):558. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. PMID: 27919080.
      View in: PubMed   Mentions: 2     Fields:    
    16. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes Dev. 2016 08 01; 30(15):1698-703. Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. PMID: 27492367; PMCID: PMC5002975.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    17. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. 2016 06 14; 6(6):806-814. Porter SN, Cluster AS, Signer RAJ, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA. PMID: 27185281; PMCID: PMC4911494.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    18. Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell. 2016 Apr 07; 18(4):456-66. Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H. PMID: 27044474; PMCID: PMC4826298.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    19. Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2016 Mar 17; 531(7594):323-8. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y. PMID: 26958831; PMCID: PMC6061995.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    20. Cellular differences in protein synthesis regulate tissue homeostasis. Cell. 2014 Oct 09; 159(2):242-51. Buszczak M, Signer RA, Morrison SJ. PMID: 25303523; PMCID: PMC4222182.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    21. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife. 2014 May 07; 3:e02669. Mich JK, Signer RA, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ. PMID: 24843006; PMCID: PMC4038845.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    22. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014 May 01; 509(7498):49-54. Signer RA, Magee JA, Salic A, Morrison SJ. PMID: 24670665; PMCID: PMC4015626.
      View in: PubMed   Mentions: 312     Fields:    Translation:AnimalsCells
    23. Mechanisms that regulate stem cell aging and life span. Cell Stem Cell. 2013 Feb 07; 12(2):152-65. Signer RA, Morrison SJ. PMID: 23395443; PMCID: PMC3641677.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    24. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012 Jun 14; 119(24):5715-21. Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. PMID: 22555975; PMCID: PMC3382931.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    25. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 2010 Oct 07; 116(14):2522-30. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 20562326; PMCID: PMC2953887.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan; 9(1):57-62. Dorshkind K, Montecino-Rodriguez E, Signer RA. PMID: 19104499.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    27. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15; 22(22):3115-20. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 19056891; PMCID: PMC2593609.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    28. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007 Sep 15; 110(6):1831-9. Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. PMID: 17554060; PMCID: PMC1976345.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    29. Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp Gerontol. 2007 May; 42(5):391-5. Signer RA, Montecino-Rodriguez E, Dorshkind K. PMID: 17184948; PMCID: PMC1924911.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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