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Leslie Crews

Title(s)Assistant Adjunct Professor, Medicine
SchoolHealth Sciences
Phone858-822-5785
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, La Jolla, CAPhD2010Molecular Pathology
    University of California, Los Angeles, Los Angeles, CABS2003Microbiology, Immunology and Molecular Genetics
    University of Glasgow, Scotland, UK2002Microbiology and Immunology
    Collapse Awards and Honors
    2017Lund Stem Cell Center Award for Novel Conceptual Advance in Stem Cell Biology
    2015Association for Women in Science San Diego Chapter Award for Leadership Service
    UC San Diego2013  - 2014Multiple Myeloma Research Foundation Fellow Award
    UC San Diego2013  - 2014The San Diego Foundation Science & Technology Grant
    UC San Diego2006  - 2007Neuroplasticity of Aging UCSD Training Grant Pre-Doctoral Fellowship
    UC Los Angeles1999  - 2003Robert C. Byrd Scholarship

    Collapse Overview 

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lazzari E, Mondala PK, Santos ND, Miller AC, Pineda G, Jiang Q, Leu H, Ali SA, Ganesan AP, Wu CN, Costello C, Minden M, Chiaramonte R, Stewart AK, Crews LA, Jamieson CHM. Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun. 2017 12 04; 8(1):1922. PMID: 29203771.
      View in: PubMed
    2. Jiang Q, Crews LA, Holm F, Jamieson CHM. RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nat Rev Cancer. 2017 06; 17(6):381-392. PMID: 28416802.
      View in: PubMed
    3. Colombo M, Galletti S, Bulfamante G, Falleni M, Tosi D, Todoerti K, Lazzari E, Crews LA, Jamieson CH, Ravaioli S, Baccianti F, Garavelli S, Platonova N, Neri A, Chiaramonte R. Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Oncotarget. 2016 Aug 30; 7(35):56013-56029. PMID: 27463014.
      View in: PubMed
    4. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 11 03; 19(5):599-612. PMID: 27570067.
      View in: PubMed
    5. Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q, Jamieson CHM. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 08 04; 19(2):177-191. PMID: 27292188.
      View in: PubMed
    6. Crews LA, Jiang Q, Zipeto MA, Lazzari E, Court AC, Ali S, Barrett CL, Frazer KA, Jamieson CH. An RNA editing fingerprint of cancer stem cell reprogramming. J Transl Med. 2015 Feb 12; 13:52. PMID: 25889244; PMCID: PMC4341880.
      View in: PubMed, PubMed Central
    7. Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015; 13(1):43-54. PMID: 25760044; PMCID: PMC4455959.
      View in: PubMed, PubMed Central
    8. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. PMID: 25117211.
      View in: PubMed
    9. Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, Frazer KA, Jamieson CH. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1041-6. PMID: 23275297; PMCID: PMC3549099.
      View in: PubMed, PubMed Central
    10. Sullivan BD, Crews LA, Messmer EM, Foulks GN, Nichols KK, Baenninger P, Geerling G, Figueiredo F, Lemp MA. Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications. Acta Ophthalmol. 2014 Mar; 92(2):161-6. PMID: 23279964.
      View in: PubMed
    11. Sullivan BD, Crews LA, Sönmez B, de la Paz MF, Comert E, Charoenrook V, de Araujo AL, Pepose JS, Berg MS, Kosheleff VP, Lemp MA. Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management. Cornea. 2012 Sep; 31(9):1000-8. PMID: 22475641.
      View in: PubMed
    12. Crews LA, Jamieson CH. Selective elimination of leukemia stem cells: hitting a moving target. Cancer Lett. 2013 Sep 10; 338(1):15-22. PMID: 22906415.
      View in: PubMed
    13. Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. a-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. J Biol Chem. 2012 Sep 14; 287(38):31691-702. PMID: 22833673; PMCID: PMC3442504.
      View in: PubMed, PubMed Central
    14. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. PMID: 22768113; PMCID: PMC3387267.
      View in: PubMed, PubMed Central
    15. Crews LA, Jamieson CH. Chronic myeloid leukemia stem cell biology. Curr Hematol Malig Rep. 2012 Jun; 7(2):125-32. PMID: 22467334; PMCID: PMC3342507.
      View in: PubMed, PubMed Central
    16. Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 2012 May; 31(5):472-8. PMID: 22378109.
      View in: PubMed
    17. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. Role of a-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. PMID: 22251432; PMCID: PMC3925782.
      View in: PubMed, PubMed Central
    18. Crews L, Ruf R, Patrick C, Dumaop W, Trejo-Morales M, Achim CL, Rockenstein E, Masliah E. Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders. Mol Neurodegener. 2011 Sep 24; 6:67. PMID: 21943307; PMCID: PMC3204248.
      View in: PubMed, PubMed Central
    19. Paulino AD, Ubhi K, Rockenstein E, Adame A, Crews L, Letendre S, Ellis R, Everall IP, Grant I, Masliah E. Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling. J Neurovirol. 2011 Aug; 17(4):327-40. PMID: 21660601; PMCID: PMC3919659.
      View in: PubMed, PubMed Central
    20. Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One. 2011 Apr 29; 6(4):e19338. PMID: 21559417; PMCID: PMC3084838.
      View in: PubMed, PubMed Central
    21. Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. Am J Pathol. 2011 Apr; 178(4):1646-61. PMID: 21435449; PMCID: PMC3078446.
      View in: PubMed, PubMed Central
    22. Crews L, Patrick C, Adame A, Rockenstein E, Masliah E. Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death Dis. 2011 Feb 10; 2:e120. PMID: 21368891; PMCID: PMC3101702.
      View in: PubMed, PubMed Central
    23. Rockenstein E, Ubhi K, Doppler E, Novak P, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Crews L, Masliah E. Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AßPP transgenic mice. J Alzheimers Dis. 2011; 27(4):743-52. PMID: 21860085; PMCID: PMC3925781.
      View in: PubMed, PubMed Central
    24. Crews L, Adame A, Patrick C, Delaney A, Pham E, Rockenstein E, Hansen L, Masliah E. Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. J Neurosci. 2010 Sep 15; 30(37):12252-62. PMID: 20844121; PMCID: PMC2978735.
      View in: PubMed, PubMed Central
    25. Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J. 2010 Jul; 277(14):3051-67. PMID: 20573181; PMCID: PMC2933033.
      View in: PubMed, PubMed Central
    26. Crews L, Masliah E. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet. 2010 Apr 15; 19(R1):R12-20. PMID: 20413653; PMCID: PMC2875049.
      View in: PubMed, PubMed Central
    27. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One. 2010 Feb 19; 5(2):e9313. PMID: 20174468.
      View in: PubMed
    28. Crews L, Rockenstein E, Masliah E. APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Struct Funct. 2010 Mar; 214(2-3):111-26. PMID: 20091183; PMCID: PMC2847155.
      View in: PubMed, PubMed Central
    29. Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13010-5. PMID: 19651612; PMCID: PMC2722313.
      View in: PubMed, PubMed Central
    30. Crews L, Tsigelny I, Hashimoto M, Masliah E. Role of synucleins in Alzheimer's disease. Neurotox Res. 2009 Oct; 16(3):306-17. PMID: 19551456; PMCID: PMC2727399.
      View in: PubMed, PubMed Central
    31. Crews L, Patrick C, Achim CL, Everall IP, Masliah E. Molecular pathology of neuro-AIDS (CNS-HIV). Int J Mol Sci. 2009 Mar; 10(3):1045-63. PMID: 19399237; PMCID: PMC2672018.
      View in: PubMed, PubMed Central
    32. Ubhi K, Rockenstein E, Doppler E, Mante M, Adame A, Patrick C, Trejo M, Crews L, Paulino A, Moessler H, Masliah E. Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin. Acta Neuropathol. 2009 Jun; 117(6):699-712. PMID: 19252918; PMCID: PMC3049872.
      View in: PubMed, PubMed Central
    33. Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25. PMID: 19176820; PMCID: PMC2768399.
      View in: PubMed, PubMed Central
    34. Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem. 2009 Mar; 108(6):1561-74. PMID: 19166511; PMCID: PMC3902824.
      View in: PubMed, PubMed Central
    35. Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109. PMID: 19014502; PMCID: PMC2596170.
      View in: PubMed, PubMed Central
    36. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. PMID: 18769546; PMCID: PMC2519786.
      View in: PubMed, PubMed Central
    37. Crews L, Lentz MR, Gonzalez RG, Fox HS, Masliah E. Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS. J Neurovirol. 2008 Aug; 14(4):327-39. PMID: 18780234; PMCID: PMC2562423.
      View in: PubMed, PubMed Central
    38. Doppler E, Rockenstein E, Ubhi K, Inglis C, Mante M, Adame A, Crews L, Hitzl M, Moessler H, Masliah E. Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome. Acta Neuropathol. 2008 Oct; 116(4):425-37. PMID: 18600331; PMCID: PMC2732193.
      View in: PubMed, PubMed Central
    39. Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. J Neurosci. 2008 Apr 16; 28(16):4250-60. PMID: 18417705; PMCID: PMC2666311.
      View in: PubMed, PubMed Central
    40. Bar-On P, Crews L, Koob AO, Mizuno H, Adame A, Spencer B, Masliah E. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J Neurochem. 2008 Jun; 105(5):1656-67. PMID: 18248604; PMCID: PMC2822545.
      View in: PubMed, PubMed Central
    41. Kawahara K, Hashimoto M, Bar-On P, Ho GJ, Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E. alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. J Biol Chem. 2008 Mar 14; 283(11):6979-87. PMID: 18195004.
      View in: PubMed
    42. Crews L, Rockenstein E, Masliah E. Biological transgenic mouse models of Alzheimer's disease. Handb Clin Neurol. 2008; 89:291-301. PMID: 18631753.
      View in: PubMed
    43. Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 2007 Dec; 7(12):1853-67. PMID: 18034651.
      View in: PubMed
    44. Salaria S, Badkoobehi H, Rockenstein E, Crews L, Chana G, Masliah E, Everall IP. Toll-like receptor pathway gene expression is associated with human immunodeficiency virus-associated neurodegeneration. J Neurovirol. 2007 Dec; 13(6):496-503. PMID: 18097881.
      View in: PubMed
    45. Rockenstein E, Crews L, Masliah E. Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev. 2007 Sep 30; 59(11):1093-102. PMID: 17869376.
      View in: PubMed
    46. Letendre S, Paulino AD, Rockenstein E, Adame A, Crews L, Cherner M, Heaton R, Ellis R, Everall IP, Grant I, Masliah E. Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. J Infect Dis. 2007 Aug 01; 196(3):361-70. PMID: 17597450.
      View in: PubMed
    47. Kuczenski R, Everall IP, Crews L, Adame A, Grant I, Masliah E. Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat. Exp Neurol. 2007 Sep; 207(1):42-51. PMID: 17603040; PMCID: PMC2796472.
      View in: PubMed, PubMed Central
    48. Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007 Apr; 274(7):1862-77. PMID: 17381514.
      View in: PubMed
    49. Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose JB, Crews L, Masliah E. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21; 27(8):1981-91. PMID: 17314294.
      View in: PubMed
    50. Spencer B, Crews L, Masliah E. Climbing the scaffolds of Parkinson's disease pathogenesis. Neuron. 2007 Feb 15; 53(4):469-70. PMID: 17296545.
      View in: PubMed
    51. Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease. Acta Neuropathol. 2007 Mar; 113(3):265-75. PMID: 17131129.
      View in: PubMed
    52. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest. 2006 Nov; 116(11):3060-9. PMID: 17080199; PMCID: PMC1626127.
      View in: PubMed, PubMed Central
    53. Chana G, Everall IP, Crews L, Langford D, Adame A, Grant I, Cherner M, Lazzaretto D, Heaton R, Ellis R, Masliah E. Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users. Neurology. 2006 Oct 24; 67(8):1486-9. PMID: 17060582.
      View in: PubMed
    54. Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease. J Neurosci Res. 2006 May 15; 83(7):1252-61. PMID: 16511867.
      View in: PubMed
    55. Webster B, Hansen L, Adame A, Crews L, Torrance M, Thal L, Masliah E. Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease. J Neuropathol Exp Neurol. 2006 Feb; 65(2):142-51. PMID: 16462205.
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    56. Masliah E, Crews L, Hansen L. Synaptic remodeling during aging and in Alzheimer's disease. J Alzheimers Dis. 2006; 9(3 Suppl):91-9. PMID: 16914848.
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    57. Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E. Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. J Neurosci. 2005 Nov 16; 25(46):10689-99. PMID: 16291942.
      View in: PubMed
    58. Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005 Oct; 8(10):1343-9. PMID: 16136043.
      View in: PubMed
    59. Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. J Biol Chem. 2005 Sep 23; 280(38):32957-67. PMID: 16027115.
      View in: PubMed
    60. Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron. 2005 Jun 16; 46(6):857-68. PMID: 15953415.
      View in: PubMed
    61. Rockenstein E, Schwach G, Ingolic E, Adame A, Crews L, Mante M, Pfragner R, Schreiner E, Windisch M, Masliah E. Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein. J Neurosci Res. 2005 Apr 15; 80(2):247-59. PMID: 15765523.
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    62. Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, Seubert P, Games D, Kirby L, Schenk D. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology. 2005 Jan 11; 64(1):129-31. PMID: 15642916.
      View in: PubMed
    63. Langford D, Grigorian A, Hurford R, Adame A, Crews L, Masliah E. The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons. J Neurovirol. 2004 Dec; 10(6):327-37. PMID: 15765804.
      View in: PubMed
    64. Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Ther. 2004 Dec; 11(23):1713-23. PMID: 15483670.
      View in: PubMed
    65. Masliah E, Roberts ES, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox HS. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. J Neuroimmunol. 2004 Dec; 157(1-2):163-75. PMID: 15579294.
      View in: PubMed
    66. Rockenstein E, Adame A, Mante M, Larrea G, Crews L, Windisch M, Moessler H, Masliah E. Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin. J Neural Transm (Vienna). 2005 Feb; 112(2):269-82. PMID: 15657642.
      View in: PubMed
    67. Crews L, Wyss-Coray T, Masliah E. Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Brain Pathol. 2004 Jul; 14(3):312-6. PMID: 15446587.
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    68. Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E. Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease. J Biol Chem. 2004 May 28; 279(22):23622-9. PMID: 15026413.
      View in: PubMed
    69. Hashimoto M, Kawahara K, Bar-On P, Rockenstein E, Crews L, Masliah E. The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease. J Mol Neurosci. 2004; 24(3):343-52. PMID: 15655259.
      View in: PubMed
    70. Hashimoto M, Rockenstein E, Crews L, Masliah E. Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases. Neuromolecular Med. 2003; 4(1-2):21-36. PMID: 14528050.
      View in: PubMed
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