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Leslie Crews

Title(s)Assistant Adjunct Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone8/8-22--5785
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, La Jolla, CAPhD2010Molecular Pathology
    University of California, Los Angeles, Los Angeles, CABS2003Microbiology, Immunology and Molecular Genetics
    University of Glasgow, Scotland, UK2002Microbiology and Immunology
    Collapse Awards and Honors
    2017Lund Stem Cell Center Award for Novel Conceptual Advance in Stem Cell Biology
    2015Association for Women in Science San Diego Chapter Award for Leadership Service
    UC San Diego2013  - 2014Multiple Myeloma Research Foundation Fellow Award
    UC San Diego2013  - 2014The San Diego Foundation Science & Technology Grant
    UC San Diego2006  - 2007Neuroplasticity of Aging UCSD Training Grant Pre-Doctoral Fellowship
    UC Los Angeles1999  - 2003Robert C. Byrd Scholarship

    Collapse Overview 

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nat Rev Cancer. 2017 06; 17(6):381-392. Jiang Q, Crews LA, Holm F, Jamieson CHM. PMID: 28416802.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    2. Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Oncotarget. 2016 Aug 30; 7(35):56013-56029. Colombo M, Galletti S, Bulfamante G, Falleni M, Tosi D, Todoerti K, Lazzari E, Crews LA, Jamieson CH, Ravaioli S, Baccianti F, Garavelli S, Platonova N, Neri A, Chiaramonte R. PMID: 27463014.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    3. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 11 03; 19(5):599-612. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM. PMID: 27570067.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    4. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 08 04; 19(2):177-191. Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q, Jamieson CHM. PMID: 27292188.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    5. An RNA editing fingerprint of cancer stem cell reprogramming. J Transl Med. 2015 Feb 12; 13:52. Crews LA, Jiang Q, Zipeto MA, Lazzari E, Court AC, Ali S, Barrett CL, Frazer KA, Jamieson CH. PMID: 25889244.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    6. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015; 13(1):43-54. Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. PMID: 25760044.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    7. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1041-6. Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, Frazer KA, Jamieson CH. PMID: 23275297.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    9. Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications. Acta Ophthalmol. 2014 Mar; 92(2):161-6. Sullivan BD, Crews LA, Messmer EM, Foulks GN, Nichols KK, Baenninger P, Geerling G, Figueiredo F, Lemp MA. PMID: 23279964.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    10. Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management. Cornea. 2012 Sep; 31(9):1000-8. Sullivan BD, Crews LA, Sönmez B, de la Paz MF, Comert E, Charoenrook V, de Araujo AL, Pepose JS, Berg MS, Kosheleff VP, Lemp MA. PMID: 22475641.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    11. Selective elimination of leukemia stem cells: hitting a moving target. Cancer Lett. 2013 Sep 10; 338(1):15-22. Crews LA, Jamieson CH. PMID: 22906415.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    12. a-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. J Biol Chem. 2012 Sep 14; 287(38):31691-702. Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. PMID: 22833673.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    13. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PMID: 22768113.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. Chronic myeloid leukemia stem cell biology. Curr Hematol Malig Rep. 2012 Jun; 7(2):125-32. Crews LA, Jamieson CH. PMID: 22467334.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    15. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea. 2012 May; 31(5):472-8. Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD. PMID: 22378109.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCTClinical Trials
    16. Role of a-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. PMID: 22251432.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    17. Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders. Mol Neurodegener. 2011 Sep 24; 6:67. Crews L, Ruf R, Patrick C, Dumaop W, Trejo-Morales M, Achim CL, Rockenstein E, Masliah E. PMID: 21943307.
      View in: PubMed   Mentions: 15     Fields:    
    18. Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling. J Neurovirol. 2011 Aug; 17(4):327-40. Paulino AD, Ubhi K, Rockenstein E, Adame A, Crews L, Letendre S, Ellis R, Everall IP, Grant I, Masliah E. PMID: 21660601.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    19. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One. 2011 Apr 29; 6(4):e19338. Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D. PMID: 21559417.
      View in: PubMed   Mentions: 169     Fields:    Translation:AnimalsCells
    20. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. Am J Pathol. 2011 Apr; 178(4):1646-61. Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E. PMID: 21435449.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    21. Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death Dis. 2011 Feb 10; 2:e120. Crews L, Patrick C, Adame A, Rockenstein E, Masliah E. PMID: 21368891.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    22. Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AßPP transgenic mice. J Alzheimers Dis. 2011; 27(4):743-52. Rockenstein E, Ubhi K, Doppler E, Novak P, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Crews L, Masliah E. PMID: 21860085.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    23. Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. J Neurosci. 2010 Sep 15; 30(37):12252-62. Crews L, Adame A, Patrick C, Delaney A, Pham E, Rockenstein E, Hansen L, Masliah E. PMID: 20844121.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    24. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J. 2010 Jul; 277(14):3051-67. Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. PMID: 20573181.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    25. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet. 2010 Apr 15; 19(R1):R12-20. Crews L, Masliah E. PMID: 20413653.
      View in: PubMed   Mentions: 155     Fields:    Translation:Humans
    26. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One. 2010 Feb 19; 5(2):e9313. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. PMID: 20174468.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    27. APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Struct Funct. 2010 Mar; 214(2-3):111-26. Crews L, Rockenstein E, Masliah E. PMID: 20091183.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    28. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13010-5. Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. PMID: 19651612.
      View in: PubMed   Mentions: 553     Fields:    Translation:HumansAnimalsCells
    29. Role of synucleins in Alzheimer's disease. Neurotox Res. 2009 Oct; 16(3):306-17. Crews L, Tsigelny I, Hashimoto M, Masliah E. PMID: 19551456.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    30. Molecular pathology of neuro-AIDS (CNS-HIV). Int J Mol Sci. 2009 Mar; 10(3):1045-63. Crews L, Patrick C, Achim CL, Everall IP, Masliah E. PMID: 19399237.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    31. Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin. Acta Neuropathol. 2009 Jun; 117(6):699-712. Ubhi K, Rockenstein E, Doppler E, Mante M, Adame A, Patrick C, Trejo M, Crews L, Paulino A, Moessler H, Masliah E. PMID: 19252918.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25. Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. PMID: 19176820.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem. 2009 Mar; 108(6):1561-74. Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. PMID: 19166511.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    34. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109. Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. PMID: 19014502.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    35. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. PMID: 18769546.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    36. Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS. J Neurovirol. 2008 Aug; 14(4):327-39. Crews L, Lentz MR, Gonzalez RG, Fox HS, Masliah E. PMID: 18780234.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    37. Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome. Acta Neuropathol. 2008 Oct; 116(4):425-37. Doppler E, Rockenstein E, Ubhi K, Inglis C, Mante M, Adame A, Crews L, Hitzl M, Moessler H, Masliah E. PMID: 18600331.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    38. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. J Neurosci. 2008 Apr 16; 28(16):4250-60. Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E. PMID: 18417705.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    39. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J Neurochem. 2008 Jun; 105(5):1656-67. Bar-On P, Crews L, Koob AO, Mizuno H, Adame A, Spencer B, Masliah E. PMID: 18248604.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    40. alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. J Biol Chem. 2008 Mar 14; 283(11):6979-87. Kawahara K, Hashimoto M, Bar-On P, Ho GJ, Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E. PMID: 18195004.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    41. Biological transgenic mouse models of Alzheimer's disease. Handb Clin Neurol. 2008; 89:291-301. Crews L, Rockenstein E, Masliah E. PMID: 18631753.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    42. Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 2007 Dec; 7(12):1853-67. Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. PMID: 18034651.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    43. Toll-like receptor pathway gene expression is associated with human immunodeficiency virus-associated neurodegeneration. J Neurovirol. 2007 Dec; 13(6):496-503. Salaria S, Badkoobehi H, Rockenstein E, Crews L, Chana G, Masliah E, Everall IP. PMID: 18097881.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    44. Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev. 2007 Sep 30; 59(11):1093-102. Rockenstein E, Crews L, Masliah E. PMID: 17869376.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    45. Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. J Infect Dis. 2007 Aug 01; 196(3):361-70. Letendre S, Paulino AD, Rockenstein E, Adame A, Crews L, Cherner M, Heaton R, Ellis R, Everall IP, Grant I, Masliah E. PMID: 17597450.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    46. Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat. Exp Neurol. 2007 Sep; 207(1):42-51. Kuczenski R, Everall IP, Crews L, Adame A, Grant I, Masliah E. PMID: 17603040.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    47. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007 Apr; 274(7):1862-77. Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JX, Masliah E. PMID: 17381514.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    48. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21; 27(8):1981-91. Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose JB, Crews L, Masliah E. PMID: 17314294.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    49. Climbing the scaffolds of Parkinson's disease pathogenesis. Neuron. 2007 Feb 15; 53(4):469-70. Spencer B, Crews L, Masliah E. PMID: 17296545.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    50. Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease. Acta Neuropathol. 2007 Mar; 113(3):265-75. Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. PMID: 17131129.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    51. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest. 2006 Nov; 116(11):3060-9. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. PMID: 17080199.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    52. Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users. Neurology. 2006 Oct 24; 67(8):1486-9. Chana G, Everall IP, Crews L, Langford D, Adame A, Grant I, Cherner M, Lazzaretto D, Heaton R, Ellis R, Masliah E. PMID: 17060582.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    53. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease. J Neurosci Res. 2006 May 15; 83(7):1252-61. Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E. PMID: 16511867.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    54. Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease. J Neuropathol Exp Neurol. 2006 Feb; 65(2):142-51. Webster B, Hansen L, Adame A, Crews L, Torrance M, Thal L, Masliah E. PMID: 16462205.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    55. Synaptic remodeling during aging and in Alzheimer's disease. J Alzheimers Dis. 2006; 9(3 Suppl):91-9. Masliah E, Crews L, Hansen L. PMID: 16914848.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    56. Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. J Neurosci. 2005 Nov 16; 25(46):10689-99. Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E. PMID: 16291942.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    57. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005 Oct; 8(10):1343-9. Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. PMID: 16136043.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    58. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. J Biol Chem. 2005 Sep 23; 280(38):32957-67. Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. PMID: 16027115.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    59. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron. 2005 Jun 16; 46(6):857-68. Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D. PMID: 15953415.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    60. Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein. J Neurosci Res. 2005 Apr 15; 80(2):247-59. Rockenstein E, Schwach G, Ingolic E, Adame A, Crews L, Mante M, Pfragner R, Schreiner E, Windisch M, Masliah E. PMID: 15765523.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    61. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology. 2005 Jan 11; 64(1):129-31. Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, Seubert P, Games D, Kirby L, Schenk D. PMID: 15642916.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansPHPublic Health
    62. The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons. J Neurovirol. 2004 Dec; 10(6):327-37. Langford D, Grigorian A, Hurford R, Adame A, Crews L, Masliah E. PMID: 15765804.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    63. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Ther. 2004 Dec; 11(23):1713-23. Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. PMID: 15483670.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    64. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. J Neuroimmunol. 2004 Dec; 157(1-2):163-75. Masliah E, Roberts ES, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox HS. PMID: 15579294.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    65. Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin. J Neural Transm (Vienna). 2005 Feb; 112(2):269-82. Rockenstein E, Adame A, Mante M, Larrea G, Crews L, Windisch M, Moessler H, Masliah E. PMID: 15657642.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    66. Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Brain Pathol. 2004 Jul; 14(3):312-6. Crews L, Wyss-Coray T, Masliah E. PMID: 15446587.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    67. Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease. J Biol Chem. 2004 May 28; 279(22):23622-9. Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E. PMID: 15026413.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    68. The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease. J Mol Neurosci. 2004; 24(3):343-52. Hashimoto M, Kawahara K, Bar-On P, Rockenstein E, Crews L, Masliah E. PMID: 15655259.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
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