Ida Deichaite

Title(s)Assistant Adjunct Professor, Radiation Medicine and Applied Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-8839-0573 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Hebrew University, Jerusalem, IsraelB.Sc.05/1983Horticulture
    Weizmann Institute, Rehovot, IsraelM.Sc.01/1985Virology
    Princeton University, Princeton, NJPh.D.11/1991Molecular Biology
    Memorial Sloan Kettering Cancer Center, New York, NY1993Molecular Biology
    Collapse Awards and Honors
    International Cancer Education Conference, Atlanta, GA20181st Prize - Best Poster Presentation
    UC San Diego, La Jolla, CA2014Employee of the Year
    Princeton University, Princeton, NJ1986Fellowship Award
    Weizmann Institute, Rehovot, Israel1985M.Sc. Cum Laude

    Collapse Overview 
    Collapse Overview
    My background is in virology and molecular biology. I have applied my expertise in the field of pan-cancer genomics. As an Assistant Professor in the Department of Radiation Medicine and Applied Sciences (RMAS) at the University of California, San Diego (UCSD), I am conducting genomics analysis to identify susceptibility targets for aggressive cancers. My bed-to-bench approach to studying real-world genomics paired with clinical data facilitates translational programs by helping overcome the limitations of experimental models for rapid translation into clinic. The overarching goal of my research program is to identify and validate actionable targets and new targetable mechanism for oncology diagnostic and therapeutic development. Prior to accepting the faculty position in November 2019, I worked closely with UCSD Moores Cancer Center leadership, the private sectors, and grant agencies to develop innovative translation programs initiated at our cancer center. I applied my scientific and business development background to support the experimental design for translational objectives and the fulfillment of pre-IND-required studies. I was directly involved in four programs that resulted in FDA approvals as well as high-visibility acquisitions. These included the development of Daurismo (glasdegib) in collaboration with Pfizer (approved in 2018) and the development of TG101348 in collaboration with TargeGen, which resulted in its acquisition by Sanofi followed by Impact Biomedicines. Later, it was acquired by Celgene/BMS in a $7 billion deal and FDA approval was granted for INREBIC (fedratinib). Also, during my tenure, the ROR1 licensing to Oncternal (clinical stage) materialized, and VelosBio was acquired by Merck in a $2.8 billion deal.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multidimensional biomarker predicts disease control in response to immunotherapy in recurrent or metastatic head and neck squamous-cell carcinoma. J Cancer Res Clin Oncol. 2023 Nov; 149(15):14125-14136. Flanagan KC, Earls J, Schillebeeckx I, Hiken J, Wellinghoff RL, LaFranzo NA, Bradley ZS, Babbitt J, Westra WH, Hsu R, Nadauld L, Mcleod H, Firth SD, Sharp B, Fuller J, Vavinskaya V, Sutton L, Deichaite I, Bailey SD, Sandulache VC, Rendo MJ, Macdonald OK, Welaya K, Wade JL, Pippas AW, Slim J, Bank B, Saccaro SJ, Sui X, Akhtar A, Balaraman S, Kossman SE, Sonnier SA, Shenkenberg TD, Alexander WL, Price KA, Bane CL, Ley J, Messina DN, Glasscock JI, Cohen EEW, Adkins DR, Duncavage EJ. PMID: 37552307; PMCID: PMC10590294.
      View in: PubMed   Mentions: 1     Fields:    
    2. Differential regulation of TNFα and IL-6 expression contributes to immune evasion in prostate cancer. J Transl Med. 2022 11 12; 20(1):527. Deichaite I, Sears TJ, Sutton L, Rebibo D, Morgan K, Nelson T, Rose B, Tamayo P, Ferrara N, Asimakopoulos F, Carter H. PMID: 36371231; PMCID: PMC9652804.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Germline genetic biomarkers to stratify patients for personalized radiation treatment. J Transl Med. 2022 08 12; 20(1):360. Deichaite I, Hopper A, Krockenberger L, Sears TJ, Sutton L, Ray X, Sharabi A, Navon A, Sanghvi P, Carter H, Moiseenko V. PMID: 35962345; PMCID: PMC9373374.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Evaluating predictive factors for toxicities experienced by head & neck cancer patients undergoing radiotherapy. J Transl Med. 2021 09 07; 19(1):380. Ray X, Sumner W, Sutton L, Sanghvi P, Deichaite I, Moiseenko V. PMID: 34493300; PMCID: PMC8425061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma. J Transl Med. 2021 05 17; 19(1):212. Sumner W, Ray X, Sutton L, Rebibo D, Marincola F, Sanghvi P, Moiseenko V, Deichaite I. PMID: 34001187; PMCID: PMC8130372.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    6. Time for a change: considering the rights of study participants to ownership of their personal research-grade genomic data. Convergent Science Physical Oncology. 2018; 4(4). Lu, A., Kuhn, P., & Deichaite, I. View Publication.
    7. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. PMID: 22768113; PMCID: PMC3387267.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    8. Regulation of enzymatic activity by active site fatty acylation. A new role for long chain fatty acid acylation of proteins. J Biol Chem. 1994 Mar 04; 269(9):6498-505. Berthiaume L, Deichaite I, Peseckis S, Resh MD. PMID: 8120000.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    9. Novel use of an iodo-myristyl-CoA analog identifies a semialdehyde dehydrogenase in bovine liver. J Biol Chem. 1993 Jun 25; 268(18):13738-47. Deichaite I, Berthiaume L, Peseckis SM, Patton WF, Resh MD. PMID: 8514806.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Iodinated fatty acids as probes for myristate processing and function. Incorporation into pp60v-src. J Biol Chem. 1993 Mar 05; 268(7):5107-14. Peseckis SM, Deichaite I, Resh MD. PMID: 8444887.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    11. In vitro synthesis of pp60v-src: myristylation in a cell-free system. Mol Cell Biol. 1988 Oct; 8(10):4295-301. Deichaite I, Casson LP, Ling HP, Resh MD. PMID: 3141787; PMCID: PMC365502.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    12. Linear simian virus 40 DNA fragments exhibit a propensity for rolling-circle replication. Mol Cell Biol. 1985 Jul; 5(7):1787-90. Deichaite I, Laver-Rudich Z, Dorsett D, Winocour E. PMID: 2991751; PMCID: PMC367299.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Circular and linear simian virus 40 DNAs differ in recombination. Mol Cell Biol. 1985 Apr; 5(4):869-80. Dorsett D, Deichaite I, Winocour E. PMID: 2985972; PMCID: PMC366792.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
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